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Conserved domains on  [gi|1268227615|gb|PHJ16034|]
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myb family dna-binding domain-containing protein, partial [Cystoisospora suis]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 13419667)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor; similar to Dictyostelium discoideum Myb protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 9-61 1.13e-32

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 112.40  E-value: 1.13e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1268227615   9 PSVKKTEWTREEEEKLLHLAKLFPTQWRTIAPIVGRTAHQCLEHYEKLLDQAQ 61
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLDEAQ 53
REB1 super family cl34920
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 3-180 1.43e-24

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5147:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 100.63  E-value: 1.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268227615   3 RYEWLDPSVKKTEWTREEEEKLLHLAKLFPTQWRTIAPIV-GRTAHQCLEHYeklLDQAQGIDDEEEGKPKkalvptnar 81
Cdd:COG5147    62 WNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTIADYKdRRTAQQCVERY---VNTLEDLSSTHDSKLQ--------- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268227615  82 raglrgstkgtrledpRRLRPGEIDPHPETKPSRADAIDMHDDEKEMLQEARARLANTRGKKAKRKAREKQLEEARRLAS 161
Cdd:COG5147   130 ----------------RRNEFDKIDPFNENSARRPDIYEDELLEREVNREASYRLRVPRVSKADVKPREKGEENNPDIED 193

                         170
                  ....*....|....*....
gi 1268227615 162 LQKRREMKAAGLITSLRGP 180
Cdd:COG5147   194 LQEMKELKSASITRHLILP 212
 
Name Accession Description Interval E-value
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 9-61 1.13e-32

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 112.40  E-value: 1.13e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1268227615   9 PSVKKTEWTREEEEKLLHLAKLFPTQWRTIAPIVGRTAHQCLEHYEKLLDQAQ 61
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLDEAQ 53
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 3-180 1.43e-24

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 100.63  E-value: 1.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268227615   3 RYEWLDPSVKKTEWTREEEEKLLHLAKLFPTQWRTIAPIV-GRTAHQCLEHYeklLDQAQGIDDEEEGKPKkalvptnar 81
Cdd:COG5147    62 WNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTIADYKdRRTAQQCVERY---VNTLEDLSSTHDSKLQ--------- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268227615  82 raglrgstkgtrledpRRLRPGEIDPHPETKPSRADAIDMHDDEKEMLQEARARLANTRGKKAKRKAREKQLEEARRLAS 161
Cdd:COG5147   130 ----------------RRNEFDKIDPFNENSARRPDIYEDELLEREVNREASYRLRVPRVSKADVKPREKGEENNPDIED 193

                         170
                  ....*....|....*....
gi 1268227615 162 LQKRREMKAAGLITSLRGP 180
Cdd:COG5147   194 LQEMKELKSASITRHLILP 212
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 13-57 2.83e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 48.27  E-value: 2.83e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1268227615  13 KTEWTREEEEKLLHLAKLFPTQWRTIAPIV-GRTAHQCLEHYEKLL 57
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
13-57 3.45e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.68  E-value: 3.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1268227615   13 KTEWTREEEEKLLHLAKLFPT-QWRTIAPIVG-RTAHQCLEHYEKLL 57
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKnNWEKIAKELPgRTAEQCRERWRNLL 47
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 2-74 2.13e-03

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 38.13  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268227615   2 CRYEWLD---PSVKKTEWTREEEEKLLHLAKLFPTQWRTIA-PIVGRTAHQCLEHYEKLLDQA---QGIDDEEEgKPKKA 74
Cdd:PLN03212   64 CRLRWMNylrPSVKRGGITSDEEDLILRLHRLLGNRWSLIAgRIPGRTDNEIKNYWNTHLRKKllrQGIDPQTH-KPLDA 142
 
Name Accession Description Interval E-value
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 9-61 1.13e-32

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 112.40  E-value: 1.13e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1268227615   9 PSVKKTEWTREEEEKLLHLAKLFPTQWRTIAPIVGRTAHQCLEHYEKLLDQAQ 61
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLDEAQ 53
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 3-180 1.43e-24

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 100.63  E-value: 1.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268227615   3 RYEWLDPSVKKTEWTREEEEKLLHLAKLFPTQWRTIAPIV-GRTAHQCLEHYeklLDQAQGIDDEEEGKPKkalvptnar 81
Cdd:COG5147    62 WNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTIADYKdRRTAQQCVERY---VNTLEDLSSTHDSKLQ--------- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268227615  82 raglrgstkgtrledpRRLRPGEIDPHPETKPSRADAIDMHDDEKEMLQEARARLANTRGKKAKRKAREKQLEEARRLAS 161
Cdd:COG5147   130 ----------------RRNEFDKIDPFNENSARRPDIYEDELLEREVNREASYRLRVPRVSKADVKPREKGEENNPDIED 193

                         170
                  ....*....|....*....
gi 1268227615 162 LQKRREMKAAGLITSLRGP 180
Cdd:COG5147   194 LQEMKELKSASITRHLILP 212
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 13-57 2.83e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 48.27  E-value: 2.83e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1268227615  13 KTEWTREEEEKLLHLAKLFPTQWRTIAPIV-GRTAHQCLEHYEKLL 57
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
13-57 3.45e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.68  E-value: 3.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1268227615   13 KTEWTREEEEKLLHLAKLFPT-QWRTIAPIVG-RTAHQCLEHYEKLL 57
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKnNWEKIAKELPgRTAEQCRERWRNLL 47
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 15-57 5.26e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.87  E-value: 5.26e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1268227615  15 EWTREEEEKLLHLAKLFPT-QWRTIAPIVG-RTAHQCLEHYEKLL 57
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKnNWEKIAKELPgRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 16-58 5.83e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 36.90  E-value: 5.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1268227615  16 WTREEEEKLLHLAKLFPTQWRTIAPIVG-RTAHQCLEHYEKLLD 58
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRWRRKLN 44
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 2-74 2.13e-03

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 38.13  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268227615   2 CRYEWLD---PSVKKTEWTREEEEKLLHLAKLFPTQWRTIA-PIVGRTAHQCLEHYEKLLDQA---QGIDDEEEgKPKKA 74
Cdd:PLN03212   64 CRLRWMNylrPSVKRGGITSDEEDLILRLHRLLGNRWSLIAgRIPGRTDNEIKNYWNTHLRKKllrQGIDPQTH-KPLDA 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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