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Conserved domains on  [gi|410516878|sp|Q4IMN9|]
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RecName: Full=Protein CSN12 homolog

Protein Classification

PCI domain-containing protein( domain architecture ID 2851)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; Similar to Schizosaccharomyces pombe COP9 signalosome complex subunit 7 and Mus musculus PCI domain-containing protein 2

Gene Ontology:  GO:0000338|GO:0003690
PubMed:  9644972

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PINT super family cl02111
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
95-451 2.09e-61

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


The actual alignment was detected with superfamily member COG5600:

Pssm-ID: 470471  Cd Length: 413  Bit Score: 205.42  E-value: 2.09e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878  95 KSSWTKVYEAWKELTSVLIRGYNSH---------GFEAWTIPSLYMVGK-YLRLFAIKSDEERRakafdtgpgaslisdd 164
Cdd:COG5600   81 KRSSELLQELYKNLTAELSYSSAPHlevlvknavRMLGREIWNLTVVKKqLYGLLELKSELNQD---------------- 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 165 fdpetdkqlQLRDCEGHLKRIFSLCLNDRAP-LEESRKWGIYFVINLLFKTYFKLNSASLSRTILKTLAVYNdkgdMPPL 243
Cdd:COG5600  145 ---------NLSKISRLLTRMFNSILNDRSPaLNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVS----MPDI 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 244 EMFPKSQRVTFKFYEGVLLFLEENYIKAESHLNEAWQLCHKDAYPQSERILTYLIPCRLLTSHVLPTKALLENYPRLQdL 323
Cdd:COG5600  212 SEYQKSQVVVFHYYLGIYYLLNENFHEAFLHLNEAFLQCPWLITRNRKRILPYYIPTSLLVNKFPPTKDLLERFKRCS-V 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 324 FLPLATCIKTGNLQAFDQALQRGEAEFVKRRIYLTL-ERGRDIALRNLLRKVFIAGGFDeakeadaapvrrTRIPVAEFQ 402
Cdd:COG5600  291 YSPLVKAVRSGNIEDFDLALSRNERKFAKRGLYLTLlAHYPLVCFRNLFRKIWRLHGKQ------------SRLPLSILL 358
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 410516878 403 AAISMGSG-HLVDPDEVECMLANMIYKDLMKGYIARERGIVVLSKKGAFP 451
Cdd:COG5600  359 IVLQLSAIdNFHSFKEVECILVTLIGLGLLRGYISHSRRTVVFSKKDPFP 408
 
Name Accession Description Interval E-value
COG5600 COG5600
Transcription-associated recombination protein [DNA replication, recombination, and repair];
95-451 2.09e-61

Transcription-associated recombination protein [DNA replication, recombination, and repair];


Pssm-ID: 227887  Cd Length: 413  Bit Score: 205.42  E-value: 2.09e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878  95 KSSWTKVYEAWKELTSVLIRGYNSH---------GFEAWTIPSLYMVGK-YLRLFAIKSDEERRakafdtgpgaslisdd 164
Cdd:COG5600   81 KRSSELLQELYKNLTAELSYSSAPHlevlvknavRMLGREIWNLTVVKKqLYGLLELKSELNQD---------------- 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 165 fdpetdkqlQLRDCEGHLKRIFSLCLNDRAP-LEESRKWGIYFVINLLFKTYFKLNSASLSRTILKTLAVYNdkgdMPPL 243
Cdd:COG5600  145 ---------NLSKISRLLTRMFNSILNDRSPaLNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVS----MPDI 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 244 EMFPKSQRVTFKFYEGVLLFLEENYIKAESHLNEAWQLCHKDAYPQSERILTYLIPCRLLTSHVLPTKALLENYPRLQdL 323
Cdd:COG5600  212 SEYQKSQVVVFHYYLGIYYLLNENFHEAFLHLNEAFLQCPWLITRNRKRILPYYIPTSLLVNKFPPTKDLLERFKRCS-V 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 324 FLPLATCIKTGNLQAFDQALQRGEAEFVKRRIYLTL-ERGRDIALRNLLRKVFIAGGFDeakeadaapvrrTRIPVAEFQ 402
Cdd:COG5600  291 YSPLVKAVRSGNIEDFDLALSRNERKFAKRGLYLTLlAHYPLVCFRNLFRKIWRLHGKQ------------SRLPLSILL 358
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 410516878 403 AAISMGSG-HLVDPDEVECMLANMIYKDLMKGYIARERGIVVLSKKGAFP 451
Cdd:COG5600  359 IVLQLSAIdNFHSFKEVECILVTLIGLGLLRGYISHSRRTVVFSKKDPFP 408
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
322-446 8.36e-09

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 52.99  E-value: 8.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878  322 DLFLPLATCIKTGNLQAFDQALQR-GEAEFVKRRIYLTLERGRDIALRNLLRKVFIAggfdeakeadaapvrRTRIPVAE 400
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADyKEELLLDDGLAEHLEDLRRKIREHNLRQLSKP---------------YSSISLSD 65
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 410516878  401 FQAAISMgsghlvDPDEVECMLANMIYKDLMKGYIARERGIVVLSK 446
Cdd:pfam01399  66 LAKLLGL------SVDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
COG5600 COG5600
Transcription-associated recombination protein [DNA replication, recombination, and repair];
95-451 2.09e-61

Transcription-associated recombination protein [DNA replication, recombination, and repair];


Pssm-ID: 227887  Cd Length: 413  Bit Score: 205.42  E-value: 2.09e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878  95 KSSWTKVYEAWKELTSVLIRGYNSH---------GFEAWTIPSLYMVGK-YLRLFAIKSDEERRakafdtgpgaslisdd 164
Cdd:COG5600   81 KRSSELLQELYKNLTAELSYSSAPHlevlvknavRMLGREIWNLTVVKKqLYGLLELKSELNQD---------------- 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 165 fdpetdkqlQLRDCEGHLKRIFSLCLNDRAP-LEESRKWGIYFVINLLFKTYFKLNSASLSRTILKTLAVYNdkgdMPPL 243
Cdd:COG5600  145 ---------NLSKISRLLTRMFNSILNDRSPaLNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVS----MPDI 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 244 EMFPKSQRVTFKFYEGVLLFLEENYIKAESHLNEAWQLCHKDAYPQSERILTYLIPCRLLTSHVLPTKALLENYPRLQdL 323
Cdd:COG5600  212 SEYQKSQVVVFHYYLGIYYLLNENFHEAFLHLNEAFLQCPWLITRNRKRILPYYIPTSLLVNKFPPTKDLLERFKRCS-V 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878 324 FLPLATCIKTGNLQAFDQALQRGEAEFVKRRIYLTL-ERGRDIALRNLLRKVFIAGGFDeakeadaapvrrTRIPVAEFQ 402
Cdd:COG5600  291 YSPLVKAVRSGNIEDFDLALSRNERKFAKRGLYLTLlAHYPLVCFRNLFRKIWRLHGKQ------------SRLPLSILL 358
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 410516878 403 AAISMGSG-HLVDPDEVECMLANMIYKDLMKGYIARERGIVVLSKKGAFP 451
Cdd:COG5600  359 IVLQLSAIdNFHSFKEVECILVTLIGLGLLRGYISHSRRTVVFSKKDPFP 408
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
322-446 8.36e-09

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 52.99  E-value: 8.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410516878  322 DLFLPLATCIKTGNLQAFDQALQR-GEAEFVKRRIYLTLERGRDIALRNLLRKVFIAggfdeakeadaapvrRTRIPVAE 400
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADyKEELLLDDGLAEHLEDLRRKIREHNLRQLSKP---------------YSSISLSD 65
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 410516878  401 FQAAISMgsghlvDPDEVECMLANMIYKDLMKGYIARERGIVVLSK 446
Cdd:pfam01399  66 LAKLLGL------SVDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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