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Conserved domains on  [gi|81890706|sp|Q67BT3|]
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RecName: Full=Na(+)/citrate cotransporter; Short=NaCT; AltName: Full=Sodium-coupled citrate transporter; AltName: Full=Sodium-dependent citrate transporter; AltName: Full=Solute carrier family 13 member 5

Protein Classification

SLC13 family permease( domain architecture ID 12045581)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
91-551 9.31e-82

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 260.47  E-value: 9.31e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  91 LGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMiaantaveasl 170
Cdd:COG0471   1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 171 gtlelldknktselpgsqvvfedpnvqeqEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPDSkdv 250
Cdd:COG0471  70 -----------------------------GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP--- 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 251 LNYASWFGFAFPNMVMMLVLAWLWLqCLYMRHNLKKTciccgekkrdteKIAYKVLNEEYQKLGSLSYPECNVLFCFTLL 330
Cdd:COG0471 118 ISFFEWMLVGLPVALVGLLLLWLVL-YRLLPPEIKEV------------PGSKEVIREELAELGPLSRREKIALAIFALT 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 331 VILWFSRDPgfmpgwlsfawvegntVHITDATVAIFVAILLFIipsqkpkfnfssqteeerktpfypPALLDWKVAQEKV 410
Cdd:COG0471 185 VLLWITGSL----------------HGIPIAVVALLGAVLLLL------------------------TGVLTWKDAYKSI 224

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 411 PWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEP-LRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGI 489
Cdd:COG0471 225 PWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGV 304

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81890706 490 HPLYVMIPCTMSASLAFMLPVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFLSVNTW 551
Cdd:COG0471 305 NPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
CitMHS pfam03600
Citrate transporter;
11-163 4.31e-05

Citrate transporter;


:

Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 45.77  E-value: 4.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    11 FKSFAILLFTPILMLPLVILIPDKFARCAYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLF 90
Cdd:pfam03600 181 FRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFF 260

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81890706    91 LGSLIVAVAVERWKLHKRVALRMLLFVGtkPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAAN 163
Cdd:pfam03600 261 AGLFILVGALEKTGLADALADALGGLSG--LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
91-551 9.31e-82

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 260.47  E-value: 9.31e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  91 LGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMiaantaveasl 170
Cdd:COG0471   1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 171 gtlelldknktselpgsqvvfedpnvqeqEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPDSkdv 250
Cdd:COG0471  70 -----------------------------GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP--- 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 251 LNYASWFGFAFPNMVMMLVLAWLWLqCLYMRHNLKKTciccgekkrdteKIAYKVLNEEYQKLGSLSYPECNVLFCFTLL 330
Cdd:COG0471 118 ISFFEWMLVGLPVALVGLLLLWLVL-YRLLPPEIKEV------------PGSKEVIREELAELGPLSRREKIALAIFALT 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 331 VILWFSRDPgfmpgwlsfawvegntVHITDATVAIFVAILLFIipsqkpkfnfssqteeerktpfypPALLDWKVAQEKV 410
Cdd:COG0471 185 VLLWITGSL----------------HGIPIAVVALLGAVLLLL------------------------TGVLTWKDAYKSI 224

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 411 PWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEP-LRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGI 489
Cdd:COG0471 225 PWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGV 304

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81890706 490 HPLYVMIPCTMSASLAFMLPVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFLSVNTW 551
Cdd:COG0471 305 NPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 13-558 2.73e-77

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 252.29  E-value: 2.73e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    13 SFAILLFTPILMLPLVILIPDKFARCAYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQ----VCIQYMKDTNM 88
Cdd:pfam00939   8 LALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTW 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    89 LFLGSLIVAVAVERWKLHKRVALRMLLFVGTKPsrLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAANtavea 168
Cdd:pfam00939  88 LVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAF----- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   169 slgtlelldknktselpGSQVvfedpnvqeqEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELfpdSK 248
Cdd:pfam00939 161 -----------------GSDP----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI---LG 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   249 DVLNYASWFGFAFPNMVMMLVLAWLWLQCLYMrhnlkktciccGEKKRDTEkiAYKVLNEEYQKLGSLSYPECNVLFCFT 328
Cdd:pfam00939 211 VTITWASWFLAAIPPGVILLLLAPLLLYVLYP-----------PEIKSVPD--AKAIAKTELKELGPMTFREKALLGLFV 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   329 LLVILWFSrdpgfmpgwlsfawveGNTVHITDATVAIFVAILLFIIPsqkpkfnfssqteeerktpfyppaLLDWK-VAQ 407
Cdd:pfam00939 278 LLLLLWIF----------------GGSLNIDATTVAIIGLALMLLLR------------------------ILDWKdIVK 317

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   408 EKVPWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEPL--RLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMAR 485
Cdd:pfam00939 318 NKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQ 397

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81890706   486 SI-GIHPLYVMIPCTMSASLA-FMLPVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFLSVNTWGRAMFNL 558
Cdd:pfam00939 398 AIpGAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 39-548 7.03e-64

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 213.99  E-value: 7.03e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  39 AYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLFVG 118
Cdd:cd01115   1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 119 TKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAANtaveaslgtlelldknktselpgsqvvfedpnvqe 198
Cdd:cd01115  81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISP----------------------------------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 199 qedeetknmyKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPDSkdvLNYASWFGFAFPNMVMMLVLAWLWLQcl 278
Cdd:cd01115 126 ----------SRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIFR-- 190

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 279 ymrhnlkktciccgekkrdtekiaykvlneeyqklgslsypecNVLFCFTLLVILWFSRDPGFMPgwlsfawvegntVHI 358
Cdd:cd01115 191 -------------------------------------------LAVLIITIVLLAALAAITGLLP------------VSV 215

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 359 TDATVAIFVAILlfiipsqkpkfnfssqteeerktpfyppALLDWKVAQEKVPWDIVLLLGGGFAMAKGCETSGLSKWMA 438
Cdd:cd01115 216 AIAIGAIVLVFG----------------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 439 AQMEPLRLVKPAVITLILSCLVAMT-TECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTMSASLAFMLPVATPPNAI 517
Cdd:cd01115 268 EALISLLGGLPPFAILLLLCLLTLVlTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAI 347

                       490       500       510
                ....*....|....*....|....*....|.
gi 81890706 518 VFAYGHLRVVDMMKTGLIMNfvgILSVFLSV 548
Cdd:cd01115 348 VLGPGGYKFSDFAKVGLPLS---ILSLVVSV 375
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-551 6.22e-45

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 164.82  E-value: 6.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    41 VIVIMAVYWCTDVIPVAVTSLLPVLLFP----LLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLF 116
Cdd:TIGR00785  16 IFVAAIVGWILEPLPLPVTALLAIPIIAvllgVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   117 VGTKPSRL-MLGFMFVTAFLSMWISNTA-ATAMMIPIVEAMLQQMiaantaveaslgtlelldknktselpgsqvvfedp 194
Cdd:TIGR00785  96 MGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL----------------------------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   195 nvQEQEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMqelFPDSKDVLNYASWFGFAFPNMVMMLVLAWLW 274
Cdd:TIGR00785 141 --GSKPEKSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGIL---SKILGIQISWGDWFLAGLPLGIILLLLVPLL 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   275 LQCLYmRHNLKKtciccgekKRDTEKIAykvlNEEYQKLGSLSYPEcnvlfcFTLLVILWFSRDPgfmpgwlsfaWVEGN 354
Cdd:TIGR00785 216 LYVLF-PPELKL--------KDEVDLWA----KEELEEMGPMSFRE------KALLGIFLLALLL----------WIFGG 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   355 TVHITDATVAIFVAILLFIIpsqkpkfnfssqteeerktpfyppALLDWK-VAQEKVPWDIVLLLGGGFAMAKGCETSGL 433
Cdd:TIGR00785 267 SLGINASVVALLAVVLMLFL------------------------GIVTWKdIQKNKVAWNTLILFGGLIGLAGGLKKSGF 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   434 SKWMAAQMEP--LRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTMSASLA-FMLPV 510
Cdd:TIGR00785 323 IKWFSEKLVGilDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPY 402

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 81890706   511 ATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILsVFLSVNTW 551
Cdd:TIGR00785 403 ATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLI-VLLLVGTL 442
CitMHS pfam03600
Citrate transporter;
11-163 4.31e-05

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 45.77  E-value: 4.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    11 FKSFAILLFTPILMLPLVILIPDKFARCAYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLF 90
Cdd:pfam03600 181 FRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFF 260

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81890706    91 LGSLIVAVAVERWKLHKRVALRMLLFVGtkPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAAN 163
Cdd:pfam03600 261 AGLFILVGALEKTGLADALADALGGLSG--LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 11-166 1.16e-04

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 44.50  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  11 FKSFAILLFTPILMLPLVILIP-----DKFARCAYVIVIMAV-YWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMK 84
Cdd:cd01115 162 GQGFSFFEFTPIGLPLLIIGLLylwfiFRLAVLIITIVLLAAlAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDW 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  85 DTNMLFLGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLMLG-FMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAAN 163
Cdd:cd01115 242 GIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPPFAILLlLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPP 321


                ...
gi 81890706 164 TAV 166
Cdd:cd01115 322 EAL 324
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
91-551 9.31e-82

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 260.47  E-value: 9.31e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  91 LGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMiaantaveasl 170
Cdd:COG0471   1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 171 gtlelldknktselpgsqvvfedpnvqeqEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPDSkdv 250
Cdd:COG0471  70 -----------------------------GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP--- 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 251 LNYASWFGFAFPNMVMMLVLAWLWLqCLYMRHNLKKTciccgekkrdteKIAYKVLNEEYQKLGSLSYPECNVLFCFTLL 330
Cdd:COG0471 118 ISFFEWMLVGLPVALVGLLLLWLVL-YRLLPPEIKEV------------PGSKEVIREELAELGPLSRREKIALAIFALT 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 331 VILWFSRDPgfmpgwlsfawvegntVHITDATVAIFVAILLFIipsqkpkfnfssqteeerktpfypPALLDWKVAQEKV 410
Cdd:COG0471 185 VLLWITGSL----------------HGIPIAVVALLGAVLLLL------------------------TGVLTWKDAYKSI 224

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 411 PWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEP-LRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGI 489
Cdd:COG0471 225 PWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGV 304

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81890706 490 HPLYVMIPCTMSASLAFMLPVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFLSVNTW 551
Cdd:COG0471 305 NPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 13-558 2.73e-77

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 252.29  E-value: 2.73e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    13 SFAILLFTPILMLPLVILIPDKFARCAYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQ----VCIQYMKDTNM 88
Cdd:pfam00939   8 LALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTW 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    89 LFLGSLIVAVAVERWKLHKRVALRMLLFVGTKPsrLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAANtavea 168
Cdd:pfam00939  88 LVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAF----- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   169 slgtlelldknktselpGSQVvfedpnvqeqEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELfpdSK 248
Cdd:pfam00939 161 -----------------GSDP----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI---LG 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   249 DVLNYASWFGFAFPNMVMMLVLAWLWLQCLYMrhnlkktciccGEKKRDTEkiAYKVLNEEYQKLGSLSYPECNVLFCFT 328
Cdd:pfam00939 211 VTITWASWFLAAIPPGVILLLLAPLLLYVLYP-----------PEIKSVPD--AKAIAKTELKELGPMTFREKALLGLFV 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   329 LLVILWFSrdpgfmpgwlsfawveGNTVHITDATVAIFVAILLFIIPsqkpkfnfssqteeerktpfyppaLLDWK-VAQ 407
Cdd:pfam00939 278 LLLLLWIF----------------GGSLNIDATTVAIIGLALMLLLR------------------------ILDWKdIVK 317

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   408 EKVPWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEPL--RLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMAR 485
Cdd:pfam00939 318 NKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQ 397

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81890706   486 SI-GIHPLYVMIPCTMSASLA-FMLPVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFLSVNTWGRAMFNL 558
Cdd:pfam00939 398 AIpGAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 39-548 7.03e-64

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 213.99  E-value: 7.03e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  39 AYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLFVG 118
Cdd:cd01115   1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 119 TKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAANtaveaslgtlelldknktselpgsqvvfedpnvqe 198
Cdd:cd01115  81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISP----------------------------------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 199 qedeetknmyKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPDSkdvLNYASWFGFAFPNMVMMLVLAWLWLQcl 278
Cdd:cd01115 126 ----------SRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIFR-- 190

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 279 ymrhnlkktciccgekkrdtekiaykvlneeyqklgslsypecNVLFCFTLLVILWFSRDPGFMPgwlsfawvegntVHI 358
Cdd:cd01115 191 -------------------------------------------LAVLIITIVLLAALAAITGLLP------------VSV 215

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 359 TDATVAIFVAILlfiipsqkpkfnfssqteeerktpfyppALLDWKVAQEKVPWDIVLLLGGGFAMAKGCETSGLSKWMA 438
Cdd:cd01115 216 AIAIGAIVLVFG----------------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 439 AQMEPLRLVKPAVITLILSCLVAMT-TECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTMSASLAFMLPVATPPNAI 517
Cdd:cd01115 268 EALISLLGGLPPFAILLLLCLLTLVlTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAI 347

                       490       500       510
                ....*....|....*....|....*....|.
gi 81890706 518 VFAYGHLRVVDMMKTGLIMNfvgILSVFLSV 548
Cdd:cd01115 348 VLGPGGYKFSDFAKVGLPLS---ILSLVVSV 375
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-551 6.22e-45

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 164.82  E-value: 6.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    41 VIVIMAVYWCTDVIPVAVTSLLPVLLFP----LLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLF 116
Cdd:TIGR00785  16 IFVAAIVGWILEPLPLPVTALLAIPIIAvllgVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   117 VGTKPSRL-MLGFMFVTAFLSMWISNTA-ATAMMIPIVEAMLQQMiaantaveaslgtlelldknktselpgsqvvfedp 194
Cdd:TIGR00785  96 MGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL----------------------------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   195 nvQEQEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMqelFPDSKDVLNYASWFGFAFPNMVMMLVLAWLW 274
Cdd:TIGR00785 141 --GSKPEKSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGIL---SKILGIQISWGDWFLAGLPLGIILLLLVPLL 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   275 LQCLYmRHNLKKtciccgekKRDTEKIAykvlNEEYQKLGSLSYPEcnvlfcFTLLVILWFSRDPgfmpgwlsfaWVEGN 354
Cdd:TIGR00785 216 LYVLF-PPELKL--------KDEVDLWA----KEELEEMGPMSFRE------KALLGIFLLALLL----------WIFGG 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   355 TVHITDATVAIFVAILLFIIpsqkpkfnfssqteeerktpfyppALLDWK-VAQEKVPWDIVLLLGGGFAMAKGCETSGL 433
Cdd:TIGR00785 267 SLGINASVVALLAVVLMLFL------------------------GIVTWKdIQKNKVAWNTLILFGGLIGLAGGLKKSGF 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   434 SKWMAAQMEP--LRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTMSASLA-FMLPV 510
Cdd:TIGR00785 323 IKWFSEKLVGilDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPY 402

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 81890706   511 ATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILsVFLSVNTW 551
Cdd:TIGR00785 403 ATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLI-VLLLVGTL 442
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 46-542 1.64e-34

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 134.68  E-value: 1.64e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  46 AVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLFvGTKPSRLM 125
Cdd:cd00625   1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 126 LGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAANTaveaslgtlelldknktselpgsqvvfedpnvqeqedeetk 205
Cdd:cd00625  80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPP----------------------------------------- 118

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 206 nmyKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQelfpdskdvLNYASWFGFAFPNMVMMLVLAWLWLQCLYMRHNLK 285
Cdd:cd00625 119 ---VPLLLALAFAANIGGAATPIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLL 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 286 KtciccgekKRDTEKIAYKVLNEEYQKLGSLSYpecnVLFCFTLLVILWFSrdpGFMPGWlsfawvegntvhITDATVAI 365
Cdd:cd00625 187 P--------DEDKLTVLAEPLPARPLLKKFLLL----ALLLLLLFVLLFFF---LIPLGL------------IALLGALL 239

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 366 FVAILLFIipsqkpkfnfssqteeerktpfyppalLDWKVAQEKVPWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEPLR 445
Cdd:cd00625 240 LLLLLVRG---------------------------LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALV 292

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 446 LVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMAR-----SIGIHPLYVMIPCTMSASLAFMLPVATPPNAIVfa 520
Cdd:cd00625 293 GLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPpepawLALALGSTLGGNLTLIGSLANLIPLGAAENAGV-- 370

                       490       500
                ....*....|....*....|..
gi 81890706 521 ygHLRVVDMMKTGLIMNFVGIL 542
Cdd:cd00625 371 --GISFGEFLKVGLPLTLLSLV 390
CitMHS pfam03600
Citrate transporter;
46-496 5.62e-22

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 97.38  E-value: 5.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    46 AVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLM 125
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   126 LGFMFVTAFLSMWISNTAATAMMIPIVeamlqqmiaantaveaslgtLELLDKNKTSELPgsqvvfedpnvqeqedeetk 205
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIV--------------------LALARRLGLPPSP-------------------- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   206 nmykaMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPDskdvlnyaswFGFAFPNMVMMLVLAWLWLQCLYMRHNLK 285
Cdd:pfam03600 121 -----LLIALAFAANIGGTATPIGDPPNIIIASALGLSFGD----------FGFFMFPPVGVALLLVGLLPLLLIFRKLL 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   286 KTCICCGEKKRDTEKIAYKVLneeyqklgslsypecnVLFCFTLLVILwfsrdpgfmpgwlsfAWVEGNTVHITDATVAI 365
Cdd:pfam03600 186 PVRKEEEAELEELRKRAIKDK----------------LLLAISALVLA---------------LVILGFLLLSVLALAGA 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   366 FVAILLFIIpsqkpkfnfssqteeerktpfyppallDWKVAQEKVPWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEPlr 445
Cdd:pfam03600 235 LLLLLTGVL---------------------------DPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGG-- 285

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 81890706   446 LVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMI 496
Cdd:pfam03600 286 LSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
CitMHS pfam03600
Citrate transporter;
397-546 2.02e-09

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 59.25  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706   397 PPALLDWKVAQEKVPWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEPLRLVKPAVITLILSCLVAMTTECTSNVATTTLF 476
Cdd:pfam03600  24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81890706   477 LPIFASMARSIGIHPLYVMIPCTMSASLAFML-PVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFL 546
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGL 174
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 412-546 3.43e-09

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 58.80  E-value: 3.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 412 WDIVLLLGGGFAMAKGCETSGLSKWMAAQMEpLRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGI-H 490
Cdd:cd00625  39 WETILLLFGMMILSAALEETGLFDRLAAKLA-RASKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLsP 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 81890706 491 PLYVMIPCTMSASLA-FMLPVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFL 546
Cdd:cd00625 118 PVPLLLALAFAANIGgAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLLG 174
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
361-546 1.09e-06

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 51.28  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 361 ATVAIFVAILLFIIpSQKPKFNFSSqteeerktpfypPALL-----------DWKVAQEKVPWDIVLLLGGGFAMAKGCE 429
Cdd:COG1055   4 LALAIFVLTYLLII-LEPRGLNRAV------------AALLgaalllllgvvSLEDALEAIDWNTILFLLGMMIIVAILD 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 430 TSGLSKWMAAQMEPLRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTMSASLA-FML 508
Cdd:COG1055  71 ESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGgAAT 150

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 81890706 509 PVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFL 546
Cdd:COG1055 151 PIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLL 188
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
85-493 1.28e-05

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 47.82  E-value: 1.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  85 DTNMLFLGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQM----- 159
Cdd:COG1055  54 NTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLglnpv 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 160 -------IAANTAveaSLGTLelldknktselpgsqvvFEDPnvqeqedeetknmykamhlcvcysasiggtatltgtgP 232
Cdd:COG1055 134 pfliaivFAANIG---GAATP-----------------IGNP-------------------------------------T 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 233 NVVLLGQMQelfpdskdvLNYASWFGFAFPNMVMMLVLAWLWLqCLYMRHNLKKTCIccgEKKRDTEKIAYKVLneeyqk 312
Cdd:COG1055 157 NIMIASAGG---------LSFLDFLANLFPPSLVSLLVTLLVL-YLLFRKELPAAPD---LEDDPKEAIKDRRL------ 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 313 lgslsypeCNVLFCFTLLVILWFsrdpgfmpgwlsfawVEGNTVHITDATVAIFVAILLFIIpsqkpkfnfssqteeerk 392
Cdd:COG1055 218 --------LRISLLVLALLLVGF---------------VLHSFLGLPPALIALLGAAVLLLL------------------ 256

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706 393 TPFYPPALLdwkvaqEKVPWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEPLRLVKPAVITLILSCLVAMTTECTSNVAT 472
Cdd:COG1055 257 ARVDVREVL------KKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPL 330

                       410       420
                ....*....|....*....|.
gi 81890706 473 TTLFLPIFASMARSIGIHPLY 493
Cdd:COG1055 331 VAALLPLIPDLGATGNPEPLW 351
CitMHS pfam03600
Citrate transporter;
11-163 4.31e-05

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 45.77  E-value: 4.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706    11 FKSFAILLFTPILMLPLVILIPDKFARCAYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLF 90
Cdd:pfam03600 181 FRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFF 260

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81890706    91 LGSLIVAVAVERWKLHKRVALRMLLFVGtkPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAAN 163
Cdd:pfam03600 261 AGLFILVGALEKTGLADALADALGGLSG--LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 11-166 1.16e-04

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 44.50  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  11 FKSFAILLFTPILMLPLVILIP-----DKFARCAYVIVIMAV-YWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMK 84
Cdd:cd01115 162 GQGFSFFEFTPIGLPLLIIGLLylwfiFRLAVLIITIVLLAAlAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDW 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  85 DTNMLFLGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLMLG-FMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAAN 163
Cdd:cd01115 242 GIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPPFAILLlLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPP 321


                ...
gi 81890706 164 TAV 166
Cdd:cd01115 322 EAL 324
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
41-159 2.28e-03

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 40.52  E-value: 2.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81890706  41 VIVIMAVYWCTD---VIPVAVTSLLPVLLFPLLKVLDSKQvcIQYMKDTNMLFL--GSLIVAVAVERWKLHKRVALRMLL 115
Cdd:COG0471 180 IFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKD--AYKSIPWGVLLLfgGGLALGAALEKTGLAAWLADALLP 257

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 81890706 116 FVGTKPSRLML-GFMFVTAFLSMWISNTAATAMMIPIVEAMLQQM 159
Cdd:COG0471 258 LLGGLSPLLLLlLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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