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Conserved domains on  [gi|47605629|sp|Q69384|]
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RecName: Full=Endogenous retrovirus group K member 6 Env polyprotein; AltName: Full=EnvK2 protein; AltName: Full=Envelope polyprotein; AltName: Full=HERV-K(C7) envelope protein; AltName: Full=HERV-K(HML-2.HOM) envelope protein; AltName: Full=HERV-K108 envelope protein; AltName: Full=HERV-K_7p22.1 provirus ancestral Env polyprotein; Contains: RecName: Full=Surface protein; Short=SU; Contains: RecName: Full=Transmembrane protein; Short=TM; Flags: Precursor

Protein Classification

envelope glycoprotein gp160( domain architecture ID 11238903)

envelope glycoprotein gp160 oligomerizes in the host endoplasmic reticulum into predominantly trimers, transits in the host Golgi, where glycosylation is completed, and then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HERV-K_env_2 pfam13804
Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous ...
 116-283 9.76e-126

Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous retrovirus K envelope glycoproteins.


:

Pssm-ID: 290518  Cd Length: 169  Bit Score: 370.23  E-value: 9.76e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629   116 VTWMDNPTEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPTVSPICRFTYH 195
Cdd:pfam13804   2 VTWMDNPIEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629   196 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 275
Cdd:pfam13804  82 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 161


                  ....*...
gi 47605629   276 SGQTQSCP 283
Cdd:pfam13804 162 SGQTQSCP 169
HERV-K_REC pfam15695
Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins ...
 23-105 1.58e-52

Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homolog of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis.


:

Pssm-ID: 292323  Cd Length: 87  Bit Score: 175.82  E-value: 1.58e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629    23 LTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAAANYT 102
Cdd:pfam15695   5 LTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGPMNAGAAAANIE 84


                  ...
gi 47605629   103 YWA 105
Cdd:pfam15695  85 NGA 87
HIV-1-like_HR1-HR2 cd09909
heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human ...
 501-626 2.77e-36

heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human immunodeficiency virus (HIV-1), and related domains; This domain family spans both heptad repeats of the glycoprotein (gp)/transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including human, simian, and feline immunodeficiency viruses (HIV, SIV, and FIV), bovine immunodeficiency-like virus (BIV), equine infectious anaemia virus (EIAV), and Jaagsiekte sheep retrovirus (JSRV), mouse mammary tumour virus (MMTV) and various ERVs including sheep enJSRV-26, and human ERVs (HERVs): HERV-K_c1q23.3 and HERV-K_c12q14.1. This domain belongs to a larger superfamily containing the HR1-HR2 domain of ERVs and infectious retroviruses, including Ebola virus, and Rous sarcoma virus. Proteins in this family lack the canonical CSK17-like immunosuppressive sequence, and the intrasubunit disulfide bond-forming CX6C motif found in linker region between HR1 and HR2 in the Ebola_RSV-like_HR1-HR2 family. N-terminal to the HR1-HR2 region is a fusion peptide (FP), and C-terminal is a membrane-spanning region (MSR). Viral infection involves the formation of a trimer-of-hairpins structure (three HR1 helices, buttressed by three HR2 helices lying in antiparallel orientation). In this structure, the FP (inserted in the host cell membrane) and MSR (inserted in the viral membrane) are in close proximity. ERVs are likely to originate from ancient germ-line infections by active retroviruses. Some modern ERVs, those that integrated into the host genome post-speciation, have a currently active exogenous counterpart, such as JSRV. Some ERVs play specific roles in the host, including placental development, protection of the host from infection by related pathogenic and exogenous retroviruses, and genome plasticity. Included in this subgroup are ERVs from domestic sheep that are related to JSRV, the agent of transmissible lung cancer in sheep, for example enJSRV-26 that retains an intact genome. These endogenous JSRVs protect the sheep against JSRV infection and are required for sheep placental development. HERV-K_c12q14.1 is potentially a complete envelope protein; however, it does not appear to be fusogenic.


:

Pssm-ID: 197369  Cd Length: 128  Bit Score: 132.52  E-value: 2.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629 501 VNDWQKNSTRLWNSQSSIDQ--KLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTsDFCITPQIYNESEHHWDMVRRH 578
Cdd:cd09909   1 VQARQLLVTRVQQQQSLIDAieKLEHLLNLLYWVVKQLGARVQALEFRLKIQCHLNL-WGCVTKQPYCHTDVPWNRSWNH 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47605629 579 LQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGV-ADGLANLNP 626
Cdd:cd09909  80 LQGNDNWISLTWQEWENKIDDLEEKILNLLEEAQNQLEKlADGLLSLDP 128
 
Name Accession Description Interval E-value
HERV-K_env_2 pfam13804
Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous ...
 116-283 9.76e-126

Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous retrovirus K envelope glycoproteins.


Pssm-ID: 290518  Cd Length: 169  Bit Score: 370.23  E-value: 9.76e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629   116 VTWMDNPTEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPTVSPICRFTYH 195
Cdd:pfam13804   2 VTWMDNPIEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629   196 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 275
Cdd:pfam13804  82 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 161


                  ....*...
gi 47605629   276 SGQTQSCP 283
Cdd:pfam13804 162 SGQTQSCP 169
HERV-K_REC pfam15695
Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins ...
 23-105 1.58e-52

Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homolog of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis.


Pssm-ID: 292323  Cd Length: 87  Bit Score: 175.82  E-value: 1.58e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629    23 LTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAAANYT 102
Cdd:pfam15695   5 LTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGPMNAGAAAANIE 84


                  ...
gi 47605629   103 YWA 105
Cdd:pfam15695  85 NGA 87
HIV-1-like_HR1-HR2 cd09909
heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human ...
 501-626 2.77e-36

heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human immunodeficiency virus (HIV-1), and related domains; This domain family spans both heptad repeats of the glycoprotein (gp)/transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including human, simian, and feline immunodeficiency viruses (HIV, SIV, and FIV), bovine immunodeficiency-like virus (BIV), equine infectious anaemia virus (EIAV), and Jaagsiekte sheep retrovirus (JSRV), mouse mammary tumour virus (MMTV) and various ERVs including sheep enJSRV-26, and human ERVs (HERVs): HERV-K_c1q23.3 and HERV-K_c12q14.1. This domain belongs to a larger superfamily containing the HR1-HR2 domain of ERVs and infectious retroviruses, including Ebola virus, and Rous sarcoma virus. Proteins in this family lack the canonical CSK17-like immunosuppressive sequence, and the intrasubunit disulfide bond-forming CX6C motif found in linker region between HR1 and HR2 in the Ebola_RSV-like_HR1-HR2 family. N-terminal to the HR1-HR2 region is a fusion peptide (FP), and C-terminal is a membrane-spanning region (MSR). Viral infection involves the formation of a trimer-of-hairpins structure (three HR1 helices, buttressed by three HR2 helices lying in antiparallel orientation). In this structure, the FP (inserted in the host cell membrane) and MSR (inserted in the viral membrane) are in close proximity. ERVs are likely to originate from ancient germ-line infections by active retroviruses. Some modern ERVs, those that integrated into the host genome post-speciation, have a currently active exogenous counterpart, such as JSRV. Some ERVs play specific roles in the host, including placental development, protection of the host from infection by related pathogenic and exogenous retroviruses, and genome plasticity. Included in this subgroup are ERVs from domestic sheep that are related to JSRV, the agent of transmissible lung cancer in sheep, for example enJSRV-26 that retains an intact genome. These endogenous JSRVs protect the sheep against JSRV infection and are required for sheep placental development. HERV-K_c12q14.1 is potentially a complete envelope protein; however, it does not appear to be fusogenic.


Pssm-ID: 197369  Cd Length: 128  Bit Score: 132.52  E-value: 2.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629 501 VNDWQKNSTRLWNSQSSIDQ--KLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTsDFCITPQIYNESEHHWDMVRRH 578
Cdd:cd09909   1 VQARQLLVTRVQQQQSLIDAieKLEHLLNLLYWVVKQLGARVQALEFRLKIQCHLNL-WGCVTKQPYCHTDVPWNRSWNH 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47605629 579 LQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGV-ADGLANLNP 626
Cdd:cd09909  80 LQGNDNWISLTWQEWENKIDDLEEKILNLLEEAQNQLEKlADGLLSLDP 128
GP41 pfam00517
Retroviral envelope protein; This family includes envelope protein from a variety of ...
 494-633 1.32e-15

Retroviral envelope protein; This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumour virus (MMTV) and human endogenous retroviruses (HERVs).


Pssm-ID: 395415  Cd Length: 197  Bit Score: 75.79  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629   494 SVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSDFCITPQIYNESEhHWD 573
Cdd:pfam00517   9 SIQAATLVDGLQYNVTKVMGTQQDIDKKLEARLSALEDVVRVLGEQVQSLKFRMKLQCHANYKWICVTKVPYNASD-PWD 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47605629   574 MVRRHLQG--REDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVT---WVKTI 633
Cdd:pfam00517  88 KVKKHLQGiwNNTEVSYDLLQLHNLIEDIQNQQEKTLNELDTLDNWAQSLFNWFPSLnslWRSYI 152
 
Name Accession Description Interval E-value
HERV-K_env_2 pfam13804
Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous ...
 116-283 9.76e-126

Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous retrovirus K envelope glycoproteins.


Pssm-ID: 290518  Cd Length: 169  Bit Score: 370.23  E-value: 9.76e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629   116 VTWMDNPTEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPTVSPICRFTYH 195
Cdd:pfam13804   2 VTWMDNPIEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629   196 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 275
Cdd:pfam13804  82 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 161


                  ....*...
gi 47605629   276 SGQTQSCP 283
Cdd:pfam13804 162 SGQTQSCP 169
HERV-K_REC pfam15695
Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins ...
 23-105 1.58e-52

Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homolog of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis.


Pssm-ID: 292323  Cd Length: 87  Bit Score: 175.82  E-value: 1.58e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629    23 LTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAAANYT 102
Cdd:pfam15695   5 LTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGPMNAGAAAANIE 84


                  ...
gi 47605629   103 YWA 105
Cdd:pfam15695  85 NGA 87
HIV-1-like_HR1-HR2 cd09909
heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human ...
 501-626 2.77e-36

heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human immunodeficiency virus (HIV-1), and related domains; This domain family spans both heptad repeats of the glycoprotein (gp)/transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including human, simian, and feline immunodeficiency viruses (HIV, SIV, and FIV), bovine immunodeficiency-like virus (BIV), equine infectious anaemia virus (EIAV), and Jaagsiekte sheep retrovirus (JSRV), mouse mammary tumour virus (MMTV) and various ERVs including sheep enJSRV-26, and human ERVs (HERVs): HERV-K_c1q23.3 and HERV-K_c12q14.1. This domain belongs to a larger superfamily containing the HR1-HR2 domain of ERVs and infectious retroviruses, including Ebola virus, and Rous sarcoma virus. Proteins in this family lack the canonical CSK17-like immunosuppressive sequence, and the intrasubunit disulfide bond-forming CX6C motif found in linker region between HR1 and HR2 in the Ebola_RSV-like_HR1-HR2 family. N-terminal to the HR1-HR2 region is a fusion peptide (FP), and C-terminal is a membrane-spanning region (MSR). Viral infection involves the formation of a trimer-of-hairpins structure (three HR1 helices, buttressed by three HR2 helices lying in antiparallel orientation). In this structure, the FP (inserted in the host cell membrane) and MSR (inserted in the viral membrane) are in close proximity. ERVs are likely to originate from ancient germ-line infections by active retroviruses. Some modern ERVs, those that integrated into the host genome post-speciation, have a currently active exogenous counterpart, such as JSRV. Some ERVs play specific roles in the host, including placental development, protection of the host from infection by related pathogenic and exogenous retroviruses, and genome plasticity. Included in this subgroup are ERVs from domestic sheep that are related to JSRV, the agent of transmissible lung cancer in sheep, for example enJSRV-26 that retains an intact genome. These endogenous JSRVs protect the sheep against JSRV infection and are required for sheep placental development. HERV-K_c12q14.1 is potentially a complete envelope protein; however, it does not appear to be fusogenic.


Pssm-ID: 197369  Cd Length: 128  Bit Score: 132.52  E-value: 2.77e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629 501 VNDWQKNSTRLWNSQSSIDQ--KLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTsDFCITPQIYNESEHHWDMVRRH 578
Cdd:cd09909   1 VQARQLLVTRVQQQQSLIDAieKLEHLLNLLYWVVKQLGARVQALEFRLKIQCHLNL-WGCVTKQPYCHTDVPWNRSWNH 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47605629 579 LQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGV-ADGLANLNP 626
Cdd:cd09909  80 LQGNDNWISLTWQEWENKIDDLEEKILNLLEEAQNQLEKlADGLLSLDP 128
GP41 pfam00517
Retroviral envelope protein; This family includes envelope protein from a variety of ...
 494-633 1.32e-15

Retroviral envelope protein; This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumour virus (MMTV) and human endogenous retroviruses (HERVs).


Pssm-ID: 395415  Cd Length: 197  Bit Score: 75.79  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47605629   494 SVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSDFCITPQIYNESEhHWD 573
Cdd:pfam00517   9 SIQAATLVDGLQYNVTKVMGTQQDIDKKLEARLSALEDVVRVLGEQVQSLKFRMKLQCHANYKWICVTKVPYNASD-PWD 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47605629   574 MVRRHLQG--REDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVT---WVKTI 633
Cdd:pfam00517  88 KVKKHLQGiwNNTEVSYDLLQLHNLIEDIQNQQEKTLNELDTLDNWAQSLFNWFPSLnslWRSYI 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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