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Conserved domains on  [gi|61212976|sp|Q78JE5|]
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RecName: Full=F-box only protein 22

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO22 cd22097
F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called ...
 22-69 1.19e-21

F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called FBX22, or F-box protein FBX22p44, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. FBXO22 regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438869  Cd Length: 48  Bit Score: 87.03  E-value: 1.19e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 61212976  22 LSNLAEVVERVFTFLPAKALLRVAGVCRLWRECVRRVLRTHRSVTWIS 69
Cdd:cd22097   1 LTSIAEIVERILSFLPAKALLRCARVCRLWRDCARRILRTRQRLTWIS 48
FIST super family cl34757
Small ligand-binding sensory domain FIST [Signal transduction mechanisms];
297-363 1.75e-07

Small ligand-binding sensory domain FIST [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG4398:

Pssm-ID: 443524 [Multi-domain]  Cd Length: 386  Bit Score: 52.91  E-value: 1.75e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61212976 297 DAKTVEAAMQRL---KAANIPEQNTI--GFMFACVGRG---FQyyraKGNVEADAFRKFFPSVPLFGFFGNGEIG 363
Cdd:COG4398 294 DAQAAREDLERLlaeIREELEPGRRPrgALYFSCLGRGgglFG----EPNAELQLIREALGDIPLAGFFANGEIG 364
 
Name Accession Description Interval E-value
F-box_FBXO22 cd22097
F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called ...
 22-69 1.19e-21

F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called FBX22, or F-box protein FBX22p44, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. FBXO22 regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438869  Cd Length: 48  Bit Score: 87.03  E-value: 1.19e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 61212976  22 LSNLAEVVERVFTFLPAKALLRVAGVCRLWRECVRRVLRTHRSVTWIS 69
Cdd:cd22097   1 LTSIAEIVERILSFLPAKALLRCARVCRLWRDCARRILRTRQRLTWIS 48
FIST COG4398
Small ligand-binding sensory domain FIST [Signal transduction mechanisms];
297-363 1.75e-07

Small ligand-binding sensory domain FIST [Signal transduction mechanisms];


Pssm-ID: 443524 [Multi-domain]  Cd Length: 386  Bit Score: 52.91  E-value: 1.75e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61212976 297 DAKTVEAAMQRL---KAANIPEQNTI--GFMFACVGRG---FQyyraKGNVEADAFRKFFPSVPLFGFFGNGEIG 363
Cdd:COG4398 294 DAQAAREDLERLlaeIREELEPGRRPrgALYFSCLGRGgglFG----EPNAELQLIREALGDIPLAGFFANGEIG 364
FIST_C pfam10442
FIST C domain; The FIST C domain is a novel sensory domain, which is present in signal ...
 297-363 2.64e-06

FIST C domain; The FIST C domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids.


Pssm-ID: 463094  Cd Length: 135  Bit Score: 46.54  E-value: 2.64e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61212976   297 DAKTVEAAMQRLKAANIPEQNTIGFMFACVGRGfQYYRAKGNVEADAFRKFF-PSVPLFGFFGNGEIG 363
Cdd:pfam10442  68 DADDLIEAAERAAEAALANPPEGALLFSCAGRG-LGLGERFDEELEAIREALgDGVPLAGFYTYGEIG 134
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 27-57 1.10e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 42.08  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 61212976    27 EVVERVFTFLPAKALLRVAGVCRLWRECVRR 57
Cdd:pfam12937   7 EILLQIFSYLDPKDLLRLALVCRRWRELASD 37
FBOX smart00256
A Receptor for Ubiquitination Targets;
27-57 8.82e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.65  E-value: 8.82e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 61212976     27 EVVERVFTFLPAKALLRVAGVCRLWRECVRR 57
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLIDS 34
 
Name Accession Description Interval E-value
F-box_FBXO22 cd22097
F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called ...
 22-69 1.19e-21

F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called FBX22, or F-box protein FBX22p44, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. FBXO22 regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438869  Cd Length: 48  Bit Score: 87.03  E-value: 1.19e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 61212976  22 LSNLAEVVERVFTFLPAKALLRVAGVCRLWRECVRRVLRTHRSVTWIS 69
Cdd:cd22097   1 LTSIAEIVERILSFLPAKALLRCARVCRLWRDCARRILRTRQRLTWIS 48
FIST COG4398
Small ligand-binding sensory domain FIST [Signal transduction mechanisms];
297-363 1.75e-07

Small ligand-binding sensory domain FIST [Signal transduction mechanisms];


Pssm-ID: 443524 [Multi-domain]  Cd Length: 386  Bit Score: 52.91  E-value: 1.75e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61212976 297 DAKTVEAAMQRL---KAANIPEQNTI--GFMFACVGRG---FQyyraKGNVEADAFRKFFPSVPLFGFFGNGEIG 363
Cdd:COG4398 294 DAQAAREDLERLlaeIREELEPGRRPrgALYFSCLGRGgglFG----EPNAELQLIREALGDIPLAGFFANGEIG 364
FIST_C pfam10442
FIST C domain; The FIST C domain is a novel sensory domain, which is present in signal ...
 297-363 2.64e-06

FIST C domain; The FIST C domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids.


Pssm-ID: 463094  Cd Length: 135  Bit Score: 46.54  E-value: 2.64e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61212976   297 DAKTVEAAMQRLKAANIPEQNTIGFMFACVGRGfQYYRAKGNVEADAFRKFF-PSVPLFGFFGNGEIG 363
Cdd:pfam10442  68 DADDLIEAAERAAEAALANPPEGALLFSCAGRG-LGLGERFDEELEAIREALgDGVPLAGFYTYGEIG 134
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 27-57 1.10e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 42.08  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 61212976    27 EVVERVFTFLPAKALLRVAGVCRLWRECVRR 57
Cdd:pfam12937   7 EILLQIFSYLDPKDLLRLALVCRRWRELASD 37
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 27-54 1.64e-05

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 41.86  E-value: 1.64e-05
                        10        20
                ....*....|....*....|....*...
gi 61212976  27 EVVERVFTFLPAKALLRVAGVCRLWREC 54
Cdd:cd22104   7 VVLVHIFSYLPPRDRLRASSTCRRWREA 34
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 27-56 1.95e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 41.28  E-value: 1.95e-05
                        10        20        30
                ....*....|....*....|....*....|
gi 61212976  27 EVVERVFTFLPAKALLRVAGVCRLWRECVR 56
Cdd:cd09917   6 EILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 32-57 1.61e-04

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 38.85  E-value: 1.61e-04
                        10        20
                ....*....|....*....|....*.
gi 61212976  32 VFTFLPAKALLRVAGVCRLWRECVRR 57
Cdd:cd22109  14 VFSYLDTKSLLRCAEVCREWRDVSRH 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 22-63 3.27e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.90  E-value: 3.27e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 61212976    22 LSNL-AEVVERVFTFLPAKALLRVAGVCRLWRECVRRVLRTHR 63
Cdd:pfam00646   1 LLDLpDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 27-59 5.74e-04

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 37.25  E-value: 5.74e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 61212976  27 EVVERVFTFLPAKALLR-VAGVCRLWRECVRRVL 59
Cdd:cd22095   8 ELLRNIFAFLPAEDLYQnISLVCRHWRDIVSDPL 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
27-57 8.82e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.65  E-value: 8.82e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 61212976     27 EVVERVFTFLPAKALLRVAGVCRLWRECVRR 57
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLIDS 34
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 27-56 1.48e-03

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 36.14  E-value: 1.48e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 61212976  27 EVVERVFTFLPAKALLRVAGVCRLWRECVR 56
Cdd:cd22151   6 DLLQEIFKRLDPKSLARAACVCRRWRAAAR 35
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 28-55 2.80e-03

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 35.40  E-value: 2.80e-03
                        10        20
                ....*....|....*....|....*...
gi 61212976  28 VVERVFTFLPAKALLRVAGVCRLWRECV 55
Cdd:cd22123   8 VLLEILSYLPVRDLLRISRVCKRWRRLV 35
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 26-54 4.14e-03

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 34.57  E-value: 4.14e-03
                        10        20
                ....*....|....*....|....*....
gi 61212976  26 AEVVERVFTFLPAKALLRVAGVCRLWREC 54
Cdd:cd22111   6 SRVLEVIFSYLDLPDLRNCSLVCKSWYRL 34
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 27-52 7.99e-03

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 33.92  E-value: 7.99e-03
                        10        20
                ....*....|....*....|....*.
gi 61212976  27 EVVERVFTFLPAKALLRVAGVCRLWR 52
Cdd:cd22114   7 ELLLGIFSCLCLPDLLKVSQVCKRWY 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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