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Conserved domains on  [gi|51316833|sp|Q8BRF7|]
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RecName: Full=Sec1 family domain-containing protein 1; AltName: Full=Syntaxin-binding protein 1-like 2

Protein Classification

Sec1 family protein( domain architecture ID 10469995)

Sec1 family protein such as syntaxin-binding proteins, which participate in the regulation of synaptic vesicle docking and fusion, and vacuolar protein sorting-associated protein 33A/33B/45, which play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network

CATH:  3.40.50.1910
PubMed:  8769846|15642380
SCOP:  4002933

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
41-632 9.82e-143

Sec1 family;


:

Pssm-ID: 460020  Cd Length: 506  Bit Score: 424.81  E-value: 9.82e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833    41 KVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRLCQDL--RNQLYESYYLNFISA 118
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADFisSRPKYKSYHIFFTSR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   119 ISRSKLEDIANAALAasavtqVAKVFDQYLNFITLEDDMFVLcnQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFF 198
Cdd:pfam00995  81 LSRELLEGLAEGDEV------VKKVKEINLDFIPLESDLFSL--NDPELPLYFPSYYLDLNDPVWLDELDRIAKGLLSVC 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   199 VTLGAVPIIRCsRGTAAEMVAVKLDKKLRENLRDARNslftgdplgtgQFSFQRPLLVLVDRNIDLATPLHHTWTYQALV 278
Cdd:pfam00995 153 LTLGEIPIIRY-KGPAAEMVAKKLADKLRDKIDSFAK-----------LSSDSRPVLIILDRSVDLVTPLLHQWTYQALV 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   279 HDVLD-FHLNRVNLEEStgvenspagarPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKS 357
Cdd:pfam00995 221 HDLLGiLKLNRVTLETG-----------GKEEEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKNKETRKTKG 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   358 ImglegedegaismlsDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMS---KTTLDKS 434
Cdd:pfam00995 290 I---------------ASIADLKDFVAKLPELQEEKRKLSLHTNLAEELLKIIKKRKLDELLELEQDLATgedSKQKDKL 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   435 LLDVISDPDAGT-PEDKMRLFLIYYISAQQAPSevDLEQYKKALTDAGCNLSPLqyikqwkafakmastpasygntttkp 513
Cdd:pfam00995 355 IEELIALLDADVsPLDKLRLLLLYSLTENGKSK--ELEDLKRELLQAIYGYVPL-------------------------- 406
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   514 mgllsrvmntgsqfvmegvknlvlkqqnlpVTRILDNLMEMKSNPETDDYRYFDPKMLRSNDSSV------------PRN 581
Cdd:pfam00995 407 ------------------------------LTRLVEALIKGGLLSSEFPSLKPPDPLGADLSGSVsarsksgassggSRR 456
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 51316833   582 KSPFQEAIVFVVGGGNYIEYQNLvDYIKAKQGKHILYGCSEIFNATQFIKQ 632
Cdd:pfam00995 457 SSFRQRVIVFVVGGVTYSEIRAL-RELAKKKNKEIIIGSTSILNPNSFLES 506
 
Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
41-632 9.82e-143

Sec1 family;


Pssm-ID: 460020  Cd Length: 506  Bit Score: 424.81  E-value: 9.82e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833    41 KVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRLCQDL--RNQLYESYYLNFISA 118
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADFisSRPKYKSYHIFFTSR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   119 ISRSKLEDIANAALAasavtqVAKVFDQYLNFITLEDDMFVLcnQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFF 198
Cdd:pfam00995  81 LSRELLEGLAEGDEV------VKKVKEINLDFIPLESDLFSL--NDPELPLYFPSYYLDLNDPVWLDELDRIAKGLLSVC 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   199 VTLGAVPIIRCsRGTAAEMVAVKLDKKLRENLRDARNslftgdplgtgQFSFQRPLLVLVDRNIDLATPLHHTWTYQALV 278
Cdd:pfam00995 153 LTLGEIPIIRY-KGPAAEMVAKKLADKLRDKIDSFAK-----------LSSDSRPVLIILDRSVDLVTPLLHQWTYQALV 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   279 HDVLD-FHLNRVNLEEStgvenspagarPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKS 357
Cdd:pfam00995 221 HDLLGiLKLNRVTLETG-----------GKEEEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKNKETRKTKG 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   358 ImglegedegaismlsDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMS---KTTLDKS 434
Cdd:pfam00995 290 I---------------ASIADLKDFVAKLPELQEEKRKLSLHTNLAEELLKIIKKRKLDELLELEQDLATgedSKQKDKL 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   435 LLDVISDPDAGT-PEDKMRLFLIYYISAQQAPSevDLEQYKKALTDAGCNLSPLqyikqwkafakmastpasygntttkp 513
Cdd:pfam00995 355 IEELIALLDADVsPLDKLRLLLLYSLTENGKSK--ELEDLKRELLQAIYGYVPL-------------------------- 406
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   514 mgllsrvmntgsqfvmegvknlvlkqqnlpVTRILDNLMEMKSNPETDDYRYFDPKMLRSNDSSV------------PRN 581
Cdd:pfam00995 407 ------------------------------LTRLVEALIKGGLLSSEFPSLKPPDPLGADLSGSVsarsksgassggSRR 456
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 51316833   582 KSPFQEAIVFVVGGGNYIEYQNLvDYIKAKQGKHILYGCSEIFNATQFIKQ 632
Cdd:pfam00995 457 SSFRQRVIVFVVGGVTYSEIRAL-RELAKKKNKEIIIGSTSILNPNSFLES 506
SEC1 COG5158
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular ...
9-638 4.00e-104

Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion];


Pssm-ID: 227487  Cd Length: 582  Bit Score: 327.45  E-value: 4.00e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   9 TASIRERQTVALKRMLNFNVPHVknstgepVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYF 88
Cdd:COG5158   1 NMDLLELQKNKILDEIFLVQPAN-------IWKVLLLDKDTTSILSSLITTSELLEHGITLVDLIENKREPISDLPAIYF 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833  89 VMPTEENIDRLCQDLRNqlYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLcnqnkeLV 168
Cdd:COG5158  74 VRPTKENIDLILEDLEQ--WDPFYLNYHISFLNTVTESLLELLAESGVFEKILSVYEIYLDFFVLESDLFSL------NL 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 169 SYRAINRPDITDTEMETVMdtiVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDPLgtgqf 248
Cdd:COG5158 146 PESFLESSLPSTTEALIKI---VNGLFSLCVSLGRIPIIRYSGGKNAEHMAKKLSDEIRNELSINFDGVVSKNPL----- 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 249 sfqRPLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESTgvenspagarPKRKNKKSYDLTPVDKFWQKHKG 328
Cdd:COG5158 218 ---RPILIILDRSLDPITPLLHQWTYQAMLHDLLGINNNIVTIPSSS----------VNGPEKKFSLSDKDDPFWNDNKF 284
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 329 SPFPEVAESVQQELESYraQEDEVKRLKSImglegedegaismlSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLE 408
Cdd:COG5158 285 LNFGEVGEKLKKLAKEL--KTKAQLRHKEN--------------AKSVNDIKEFVDKLPELQKRSRSLNKHLTLASELLK 348
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 409 HIKARKLDVYFEYEEKIMSKTTLDKSLLDVISDPDAGTPED-KMRLFLIYYISAQQAPSEVDLEQYkkaLTDAGCNLSPL 487
Cdd:COG5158 349 VVEERYLDDFSEIEQNLSTGNDVKSDISDLIELLESGVEEDdKLRLLILYSLTKDGLIKDIDELRL---LRIQGYGIEAL 425
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 488 ---QYIKQWKAFAKMASTPAS----YGNTTTKPMGLLSRVMNT-GSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPE 559
Cdd:COG5158 426 nffQRLKELGFLTLKDSKTISlkrgDKDSLFQWFNTYSLSREHqGVPDLENVYSGLIPLKKDIPIDLLVRRLFEPLKSSQ 505
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51316833 560 TDDYRYFDPKMLRSNDssvprNKSPFQEAIVFVVGGGNYIEYQNLVDYIKAKQGKHILYGCSEIFNATQFIKQLSQLGQ 638
Cdd:COG5158 506 QQSLRLSRPKGRSRSN-----KKIPQQRILVFVIGGVTYEELRVLYELNESQNSVRIIYGSTEILTPAEFLDEVKRLGG 579
 
Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
41-632 9.82e-143

Sec1 family;


Pssm-ID: 460020  Cd Length: 506  Bit Score: 424.81  E-value: 9.82e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833    41 KVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRLCQDL--RNQLYESYYLNFISA 118
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADFisSRPKYKSYHIFFTSR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   119 ISRSKLEDIANAALAasavtqVAKVFDQYLNFITLEDDMFVLcnQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFF 198
Cdd:pfam00995  81 LSRELLEGLAEGDEV------VKKVKEINLDFIPLESDLFSL--NDPELPLYFPSYYLDLNDPVWLDELDRIAKGLLSVC 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   199 VTLGAVPIIRCsRGTAAEMVAVKLDKKLRENLRDARNslftgdplgtgQFSFQRPLLVLVDRNIDLATPLHHTWTYQALV 278
Cdd:pfam00995 153 LTLGEIPIIRY-KGPAAEMVAKKLADKLRDKIDSFAK-----------LSSDSRPVLIILDRSVDLVTPLLHQWTYQALV 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   279 HDVLD-FHLNRVNLEEStgvenspagarPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKS 357
Cdd:pfam00995 221 HDLLGiLKLNRVTLETG-----------GKEEEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKNKETRKTKG 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   358 ImglegedegaismlsDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMS---KTTLDKS 434
Cdd:pfam00995 290 I---------------ASIADLKDFVAKLPELQEEKRKLSLHTNLAEELLKIIKKRKLDELLELEQDLATgedSKQKDKL 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   435 LLDVISDPDAGT-PEDKMRLFLIYYISAQQAPSevDLEQYKKALTDAGCNLSPLqyikqwkafakmastpasygntttkp 513
Cdd:pfam00995 355 IEELIALLDADVsPLDKLRLLLLYSLTENGKSK--ELEDLKRELLQAIYGYVPL-------------------------- 406
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   514 mgllsrvmntgsqfvmegvknlvlkqqnlpVTRILDNLMEMKSNPETDDYRYFDPKMLRSNDSSV------------PRN 581
Cdd:pfam00995 407 ------------------------------LTRLVEALIKGGLLSSEFPSLKPPDPLGADLSGSVsarsksgassggSRR 456
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 51316833   582 KSPFQEAIVFVVGGGNYIEYQNLvDYIKAKQGKHILYGCSEIFNATQFIKQ 632
Cdd:pfam00995 457 SSFRQRVIVFVVGGVTYSEIRAL-RELAKKKNKEIIIGSTSILNPNSFLES 506
SEC1 COG5158
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular ...
9-638 4.00e-104

Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion];


Pssm-ID: 227487  Cd Length: 582  Bit Score: 327.45  E-value: 4.00e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833   9 TASIRERQTVALKRMLNFNVPHVknstgepVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYF 88
Cdd:COG5158   1 NMDLLELQKNKILDEIFLVQPAN-------IWKVLLLDKDTTSILSSLITTSELLEHGITLVDLIENKREPISDLPAIYF 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833  89 VMPTEENIDRLCQDLRNqlYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLcnqnkeLV 168
Cdd:COG5158  74 VRPTKENIDLILEDLEQ--WDPFYLNYHISFLNTVTESLLELLAESGVFEKILSVYEIYLDFFVLESDLFSL------NL 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 169 SYRAINRPDITDTEMETVMdtiVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDPLgtgqf 248
Cdd:COG5158 146 PESFLESSLPSTTEALIKI---VNGLFSLCVSLGRIPIIRYSGGKNAEHMAKKLSDEIRNELSINFDGVVSKNPL----- 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 249 sfqRPLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESTgvenspagarPKRKNKKSYDLTPVDKFWQKHKG 328
Cdd:COG5158 218 ---RPILIILDRSLDPITPLLHQWTYQAMLHDLLGINNNIVTIPSSS----------VNGPEKKFSLSDKDDPFWNDNKF 284
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 329 SPFPEVAESVQQELESYraQEDEVKRLKSImglegedegaismlSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLE 408
Cdd:COG5158 285 LNFGEVGEKLKKLAKEL--KTKAQLRHKEN--------------AKSVNDIKEFVDKLPELQKRSRSLNKHLTLASELLK 348
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 409 HIKARKLDVYFEYEEKIMSKTTLDKSLLDVISDPDAGTPED-KMRLFLIYYISAQQAPSEVDLEQYkkaLTDAGCNLSPL 487
Cdd:COG5158 349 VVEERYLDDFSEIEQNLSTGNDVKSDISDLIELLESGVEEDdKLRLLILYSLTKDGLIKDIDELRL---LRIQGYGIEAL 425
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51316833 488 ---QYIKQWKAFAKMASTPAS----YGNTTTKPMGLLSRVMNT-GSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPE 559
Cdd:COG5158 426 nffQRLKELGFLTLKDSKTISlkrgDKDSLFQWFNTYSLSREHqGVPDLENVYSGLIPLKKDIPIDLLVRRLFEPLKSSQ 505
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51316833 560 TDDYRYFDPKMLRSNDssvprNKSPFQEAIVFVVGGGNYIEYQNLVDYIKAKQGKHILYGCSEIFNATQFIKQLSQLGQ 638
Cdd:COG5158 506 QQSLRLSRPKGRSRSN-----KKIPQQRILVFVIGGVTYEELRVLYELNESQNSVRIIYGSTEILTPAEFLDEVKRLGG 579
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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