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Conserved domains on  [gi|47117240|sp|Q8K0H5|]
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RecName: Full=Transcription initiation factor TFIID subunit 10; AltName: Full=Transcription initiation factor TFIID 30 kDa subunit; Short=TAF(II)30; Short=TAFII-30; Short=TAFII30; Short=mTAFII30

Protein Classification

transcription initiation factor TFIID subunit 10( domain architecture ID 10168402)

transcription initiation factor TFIID subunit 10 is part of the multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HFD_TAF10 cd07982
histone-fold domain found in transcription initiation factor TFIID subunit 10 (TAF10) and ...
 115-211 5.82e-59

histone-fold domain found in transcription initiation factor TFIID subunit 10 (TAF10) and similar proteins; TAF10, also called TATA Binding Protein (TBP) associated factor 10, STAF28, transcription initiation factor TFIID 30 kDa subunit, TAF(II)30, TAFII-30, or TAFII30, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAF10 regulates genes that are important for cell cycle progression and cell morphology. A lack of TAF10 leads to cell cycle arrest and cell death by apoptosis in mice.


:

Pssm-ID: 467026  Cd Length: 98  Bit Score: 180.45  E-value: 5.82e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240 115 PLVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDRKYT 194
Cdd:cd07982   2 ELEEFLEQLEDYTPTIPDEVTQYYLERAGFQTSDPRVVRLISLAAQKFISDIANDALQYCKMRQSAQKKKGKKGKDKKLV 81

                        90
                ....*....|....*..
gi 47117240 195 LTMEDLTPALSEYGINV 211
Cdd:cd07982  82 LTMEDLAAALKEYGINV 98
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
4-115 1.82e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240    4 SGSGADPEAATACAASVAGPAPLVSAP-AALPTSTAAESKASPAGTAGGPVAGVATAGTGPVAARAGEPAERRGPASVAA 82
Cdd:PRK12323 366 GQSGGGAGPATAAAAPVAQPAPAAAAPaAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445

                         90       100       110
                 ....*....|....*....|....*....|...
gi 47117240   83 GGAAPPEGAMSNGVYALPSAANGEVKPVVSSTP 115
Cdd:PRK12323 446 GAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAA 478
 
Name Accession Description Interval E-value
HFD_TAF10 cd07982
histone-fold domain found in transcription initiation factor TFIID subunit 10 (TAF10) and ...
 115-211 5.82e-59

histone-fold domain found in transcription initiation factor TFIID subunit 10 (TAF10) and similar proteins; TAF10, also called TATA Binding Protein (TBP) associated factor 10, STAF28, transcription initiation factor TFIID 30 kDa subunit, TAF(II)30, TAFII-30, or TAFII30, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAF10 regulates genes that are important for cell cycle progression and cell morphology. A lack of TAF10 leads to cell cycle arrest and cell death by apoptosis in mice.


Pssm-ID: 467026  Cd Length: 98  Bit Score: 180.45  E-value: 5.82e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240 115 PLVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDRKYT 194
Cdd:cd07982   2 ELEEFLEQLEDYTPTIPDEVTQYYLERAGFQTSDPRVVRLISLAAQKFISDIANDALQYCKMRQSAQKKKGKKGKDKKLV 81

                        90
                ....*....|....*..
gi 47117240 195 LTMEDLTPALSEYGINV 211
Cdd:cd07982  82 LTMEDLAAALKEYGINV 98
COG5162 COG5162
Transcription initiation factor TFIID, subunit TAF10 (also component of histone ...
 116-217 1.91e-33

Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA) [Transcription];


Pssm-ID: 227491  Cd Length: 197  Bit Score: 119.00  E-value: 1.91e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240 116 LVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDR---- 191
Cdd:COG5162  75 LEELLQNMDSYTPLIPDSVTDYYLEKAGFVTSDQRVKKLLSLLAQKFVSDIAVDAYQYSRIRQGSSNAKATAQKAKrfak 154

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47117240 192 ----------------KYTLTMEDLTPALSEYGINVKKPHYF 217
Cdd:COG5162 155 ggasgigssgrrgdrkKPVLTVVDLSKALEEYGINISRPDFY 196
TFIID_30kDa pfam03540
Transcription initiation factor TFIID 23-30kDa subunit;
129-177 5.04e-30

Transcription initiation factor TFIID 23-30kDa subunit;


Pssm-ID: 460964  Cd Length: 49  Bit Score: 105.28  E-value: 5.04e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 47117240   129 TIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMK 177
Cdd:pfam03540   1 TIPDEVTDYYLEKAGFETSDPRVKRLISLAAQKFISDIANDAYQYAKIR 49
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
4-115 1.82e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240    4 SGSGADPEAATACAASVAGPAPLVSAP-AALPTSTAAESKASPAGTAGGPVAGVATAGTGPVAARAGEPAERRGPASVAA 82
Cdd:PRK12323 366 GQSGGGAGPATAAAAPVAQPAPAAAAPaAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445

                         90       100       110
                 ....*....|....*....|....*....|...
gi 47117240   83 GGAAPPEGAMSNGVYALPSAANGEVKPVVSSTP 115
Cdd:PRK12323 446 GAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAA 478
 
Name Accession Description Interval E-value
HFD_TAF10 cd07982
histone-fold domain found in transcription initiation factor TFIID subunit 10 (TAF10) and ...
 115-211 5.82e-59

histone-fold domain found in transcription initiation factor TFIID subunit 10 (TAF10) and similar proteins; TAF10, also called TATA Binding Protein (TBP) associated factor 10, STAF28, transcription initiation factor TFIID 30 kDa subunit, TAF(II)30, TAFII-30, or TAFII30, is a TBP-associated factor (TAF). TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex, and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TFIID and PCAF are composed of TATA binding protein (TBP) and several TAFs. TBP is not part of TFTC. TAF10 regulates genes that are important for cell cycle progression and cell morphology. A lack of TAF10 leads to cell cycle arrest and cell death by apoptosis in mice.


Pssm-ID: 467026  Cd Length: 98  Bit Score: 180.45  E-value: 5.82e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240 115 PLVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDRKYT 194
Cdd:cd07982   2 ELEEFLEQLEDYTPTIPDEVTQYYLERAGFQTSDPRVVRLISLAAQKFISDIANDALQYCKMRQSAQKKKGKKGKDKKLV 81

                        90
                ....*....|....*..
gi 47117240 195 LTMEDLTPALSEYGINV 211
Cdd:cd07982  82 LTMEDLAAALKEYGINV 98
COG5162 COG5162
Transcription initiation factor TFIID, subunit TAF10 (also component of histone ...
 116-217 1.91e-33

Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA) [Transcription];


Pssm-ID: 227491  Cd Length: 197  Bit Score: 119.00  E-value: 1.91e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240 116 LVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDR---- 191
Cdd:COG5162  75 LEELLQNMDSYTPLIPDSVTDYYLEKAGFVTSDQRVKKLLSLLAQKFVSDIAVDAYQYSRIRQGSSNAKATAQKAKrfak 154

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47117240 192 ----------------KYTLTMEDLTPALSEYGINVKKPHYF 217
Cdd:COG5162 155 ggasgigssgrrgdrkKPVLTVVDLSKALEEYGINISRPDFY 196
TFIID_30kDa pfam03540
Transcription initiation factor TFIID 23-30kDa subunit;
129-177 5.04e-30

Transcription initiation factor TFIID 23-30kDa subunit;


Pssm-ID: 460964  Cd Length: 49  Bit Score: 105.28  E-value: 5.04e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 47117240   129 TIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMK 177
Cdd:pfam03540   1 TIPDEVTDYYLEKAGFETSDPRVKRLISLAAQKFISDIANDAYQYAKIR 49
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
4-115 1.82e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240    4 SGSGADPEAATACAASVAGPAPLVSAP-AALPTSTAAESKASPAGTAGGPVAGVATAGTGPVAARAGEPAERRGPASVAA 82
Cdd:PRK12323 366 GQSGGGAGPATAAAAPVAQPAPAAAAPaAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445

                         90       100       110
                 ....*....|....*....|....*....|...
gi 47117240   83 GGAAPPEGAMSNGVYALPSAANGEVKPVVSSTP 115
Cdd:PRK12323 446 GAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAA 478
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 5-91 1.12e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.31  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240    5 GSGADPEAATACAASVAGPAPLVSAPAALPTSTAAESKASPAGTAGGPVAGVATAGTGPV---AARAGEPAERRGPASVA 81
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVaapAAAAPAAAPAAAPAAVA 446

                         90
                 ....*....|
gi 47117240   82 AGGAAPPEGA 91
Cdd:PRK14951 447 LAPAPPAQAA 456
HFD_TAF8 cd22918
histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and ...
 142-212 2.35e-03

histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and similar proteins; TAF8, also called TATA Binding Protein (TBP) associated factor 8, protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, or transcription initiation factor TFIID 43 kDa subunit (TAFII-43, TAFII43), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF8 mediates both basal and activator-dependent transcription. It is involved in the differentiation of preadipocyte fibroblasts to adipocytes, however, it does not seem to play a role in differentiation of myoblasts. TAF8 is required for the integration of TAF10 in the TAF complex. It may be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.


Pssm-ID: 467043  Cd Length: 84  Bit Score: 35.99  E-value: 2.35e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47117240 142 AGFEASDPRIIRLISLAAQKFISDIANDALQHCKMkgtasgSSRSKskdrkytLTMEDLTPALSEYGINVK 212
Cdd:cd22918  17 AGFESAEKSALETLTEMLQSYLTEIGRSSKAYCEL------AGRTE-------PTLSDVVLALIDMGINVD 74
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 22-104 4.98e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 37.39  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240   22 GPAPLVSAPAALPTSTAAESKASP---AGTAGGPVAGVATAGTGPVAARAGEPAERRGPASVAAGGAAPPEGAMSNGVYA 98
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPvaqAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449


                 ....*.
gi 47117240   99 LPSAAN 104
Cdd:PRK14951 450 APPAQA 455
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 34-113 7.10e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 37.00  E-value: 7.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117240   34 PTSTAAESKASPAGTAGGPVAgvATAGTGPVAARAGEPAERRGPASVAAGGAAPPEGAMSNGVYALPSAANGEVKPVVSS 113
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEA--AAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPA 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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