large tegument protein UL36; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730413    64 TPANTPATPPNFPDALTMFSRLKASESF-HSGGSGSPMAATATSPPP---HFPHAATSSSAASSWPTAASPPGGPQHHQP 139
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVrRRPPSRSPAAKPAAPARPpvrRLARPAVSRSTESFALPPDQPERPPQPQAP 2914

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 74730413   140 QPPLWTPTPPSPASDWPPLAPQ---QATSEPRAHPAMEAE 176
Cdd:PHA03247 2915 PPPQPQPQPPPPPQPQPPPPPPprpQPPLAPTTDPAGAGE 2954

UBA-like domain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 74730413    11 QVMINQFVLTAGCAADQAKQLLQAAHWQFETALSAFFQETNIP 53
Cdd:pfam14555   1 DELIAQFQAITGADEEVARQYLEAHNWDLEAAVNAFFDDGEAS 43

UBA-like domain found in NSFL1 cofactor p47 and similar proteins; p47, also called UBX domain-containing protein 2C, is a major cofactor of the cytosolic AAA ATPase p97. It is required for the p97-regulated membrane reassembly of the endoplasmic reticulum (ER), the nuclear envelope and the Golgi apparatus. p47, together with p97, forms the p97-p47 complex that plays an important role in regulation of membrane fusion events. p47 contains an N-terminal ubiquitin-associated (UBA)-like domain, a central SEP (named after shp1, eyc and p47) domain, and a ubiquitin-like (UBX) domain. UBA-like domain is responsible for forming a highly stable complex with ubiquitin. SEP domain and UBX domain may involve in p47 trimerization or forms a stable complex with the p97 N-terminal domain.

                        10        20        30
                ....*....|....*....|....*....|....*
gi 74730413  13 MINQFVLTAGCAADQAKQLLQAAHWQFETALSAFF 47
Cdd:cd14348   3 LIAQFVSVTGADEDRAKFFLESAGWDLEAALSSFF 37

UBA-like domain found in the NXF family of mRNA nuclear export factors and similar proteins; This family includes nuclear RNA export factors (NXF1/NXF2), FAS-associated factors (FAF1/2), tyrosyl-DNA phosphodiesterase 2 (TDP2), OTU domain-containing proteins (OTU7A/OTU7B), NSFL1 cofactor p47, defective in cullin neddylation protein 1 (DCN1)-like protein (DCNL1/DCNL2), yeast defective in cullin neddylation protein 1 (DCN1) and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. FAF2 is the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. Its biological function remains unclear. TDP2 is a 5'-Tyr-DNA phosphodiesterase required for the efficient repair of topoisomerase II-induced DNA double strand breaks. OTU7A and OTU7B are zinc finger proteins that function as deubiquitinating enzymes. p47 is a major cofactor of the cytosolic AAA ATPase p97. It is required for the p97-regulated membrane reassembly of the endoplasmic reticulum (ER), the nuclear envelope and the Golgi apparatus. DCNL1 plays an essential role in the neddylation E3 complex and participates in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. The biological function of DCNL2 remains unclear. Yeast DCN1 is a scaffold-type E3 ligase for cullin neddylation. It can bind directly to cullins and the ubiquitin-like protein Nedd8-specific E2 (Ubc12), and regulate cullin neddylation and thus display ubiquitin ligase activity.

                        10        20
                ....*....|....*....|....*.
gi 74730413  22 GCAADQAKQLLQAAHWQFETALSAFF 47
Cdd:cd14273   6 GADPETARQYLESNNWDLEAAINLYF 31

UBA-like domain found in yeast UBX domain-containing protein 1 (Ubx1) and similar proteins; Ubx1, also called suppressor of high-copy PP1 protein (Shp1), is the substrate-recruiting cofactor of AAA-adenosine triphosphatase Cdc48 in Saccharomyces cerevisiae. In concert with ubiquitin-like Atg8, Cdc48 and Ubx1 are involved in the regulation of autophagosome biogenesis. Ubx1 also functions as a regulator of phosphoprotein phosphatase 1 (PP1) with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression. All family members contain an N-terminal ubiquitin-associated (UBA)-like domain.

                        10        20        30
                ....*....|....*....|....*....|....
gi 74730413  14 INQFVLTAGCAADQAKQLLQAAHWQFETALSAFF 47
Cdd:cd14351   4 IQQFMELTGASPEVAQQYLEEYGGDLNDAINAYF 37