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Conserved domains on  [gi|3024327|sp|Q90267|]
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RecName: Full=Homeobox protein OTX1 A; AltName: Full=Orthodenticle homolog 1-like; AltName: Full=zOtx3

Protein Classification

homeobox protein( domain architecture ID 11079031)

homeobox protein similar to Otx1 and Otx2 which are vertebrate homologs of the Drosophila gap gene orthodenticle and may play a role in the specification or differentiation of neurons in the deep layers of the cerebral cortex

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TF_Otx pfam03529
Otx1 transcription factor;
184-275 3.90e-21

Otx1 transcription factor;


:

Pssm-ID: 427350  Cd Length: 91  Bit Score: 86.12  E-value: 3.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024327    184 LPDISPPASASCMQRAMSSgggtTGVPSYPMPYNQAPSYAQGYPTsNAASYFGGMDCGSYLAPMTGhahhhPHAHHSQLS 263
Cdd:pfam03529   8 LPDPLAPSSASCMQRSVSS----TASASYPMSYGQASAYSQGYPA-GSSSYFGGVDCGSYLSPMHS-----QLHHPHQLS 77

                          90
                  ....*....|....
gi 3024327    264 --TAAAVSGHHHPH 275
Cdd:pfam03529  78 pmTASSMGGHLHQH 91
Homeodomain pfam00046
Homeodomain;
49-94 1.29e-19

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 81.01  E-value: 1.29e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 3024327     49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:pfam00046  11 QLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
 
Name Accession Description Interval E-value
TF_Otx pfam03529
Otx1 transcription factor;
184-275 3.90e-21

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 86.12  E-value: 3.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024327    184 LPDISPPASASCMQRAMSSgggtTGVPSYPMPYNQAPSYAQGYPTsNAASYFGGMDCGSYLAPMTGhahhhPHAHHSQLS 263
Cdd:pfam03529   8 LPDPLAPSSASCMQRSVSS----TASASYPMSYGQASAYSQGYPA-GSSSYFGGVDCGSYLSPMHS-----QLHHPHQLS 77

                          90
                  ....*....|....
gi 3024327    264 --TAAAVSGHHHPH 275
Cdd:pfam03529  78 pmTASSMGGHLHQH 91
Homeodomain pfam00046
Homeodomain;
49-94 1.29e-19

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 81.01  E-value: 1.29e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 3024327     49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:pfam00046  11 QLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 49-94 2.77e-18

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 77.67  E-value: 2.77e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 3024327   49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:cd00086  11 QLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 49-94 7.94e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 76.13  E-value: 7.94e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 3024327      49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:smart00389  12 QLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
49-131 2.98e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 2.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024327   49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQSST---NSKIRPAKKKPSPSRespgSESS 125
Cdd:COG5576  62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEqrpGEEEADLAKIGSLST----GQIS 137


                ....*.
gi 3024327  126 GHFTPP 131
Cdd:COG5576 138 IIETLE 143
 
Name Accession Description Interval E-value
TF_Otx pfam03529
Otx1 transcription factor;
184-275 3.90e-21

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 86.12  E-value: 3.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024327    184 LPDISPPASASCMQRAMSSgggtTGVPSYPMPYNQAPSYAQGYPTsNAASYFGGMDCGSYLAPMTGhahhhPHAHHSQLS 263
Cdd:pfam03529   8 LPDPLAPSSASCMQRSVSS----TASASYPMSYGQASAYSQGYPA-GSSSYFGGVDCGSYLSPMHS-----QLHHPHQLS 77

                          90
                  ....*....|....
gi 3024327    264 --TAAAVSGHHHPH 275
Cdd:pfam03529  78 pmTASSMGGHLHQH 91
Homeodomain pfam00046
Homeodomain;
49-94 1.29e-19

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 81.01  E-value: 1.29e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 3024327     49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:pfam00046  11 QLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 49-94 2.77e-18

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 77.67  E-value: 2.77e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 3024327   49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:cd00086  11 QLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 49-94 7.94e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 76.13  E-value: 7.94e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 3024327      49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:smart00389  12 QLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
49-131 2.98e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 2.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024327   49 QLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQSST---NSKIRPAKKKPSPSRespgSESS 125
Cdd:COG5576  62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEqrpGEEEADLAKIGSLST----GQIS 137


                ....*.
gi 3024327  126 GHFTPP 131
Cdd:COG5576 138 IIETLE 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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