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Conserved domains on  [gi|308153607|sp|Q9BZA5|]
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PUTATIVE PSEUDOGENE: RecName: Full=Putative gamma-taxilin 2; AltName: Full=Gamma-taxilin 2 pseudogene; AltName: Full=Taxilin gamma pseudogene, Y-linked

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Taxilin super family cl25926
Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain ...
 96-125 8.52e-06

Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.


The actual alignment was detected with superfamily member pfam09728:

Pssm-ID: 462861 [Multi-domain]  Cd Length: 302  Bit Score: 43.40  E-value: 8.52e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 308153607   96 KEVLLLMQALNTLSTPEEKLAALCKKYADL 125
Cdd:pfam09728   1 KAARELMQLLNKLDSPEEKLAALCKKYAEL 30
 
Name Accession Description Interval E-value
Taxilin pfam09728
Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain ...
 96-125 8.52e-06

Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.


Pssm-ID: 462861 [Multi-domain]  Cd Length: 302  Bit Score: 43.40  E-value: 8.52e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 308153607   96 KEVLLLMQALNTLSTPEEKLAALCKKYADL 125
Cdd:pfam09728   1 KAARELMQLLNKLDSPEEKLAALCKKYAEL 30
 
Name Accession Description Interval E-value
Taxilin pfam09728
Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain ...
 96-125 8.52e-06

Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.


Pssm-ID: 462861 [Multi-domain]  Cd Length: 302  Bit Score: 43.40  E-value: 8.52e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 308153607   96 KEVLLLMQALNTLSTPEEKLAALCKKYADL 125
Cdd:pfam09728   1 KAARELMQLLNKLDSPEEKLAALCKKYAEL 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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