RecName: Full=Sphingomyelin phosphodiesterase 3; AltName: Full=Neutral sphingomyelinase 2; Short=nSMase-2; Short=nSMase2; AltName: Full=Neutral sphingomyelinase II
Protein Classification
sphingomyelin phosphodiesterase( domain architecture ID 18076815)
sphingomyelin phosphodiesterase (sphingomyelinase or SMase) catalyzes the hydrolysis of membrane sphingomyelin to phosphorylcholine and ceramide. Eukaryotic SMases have been classified according to their pH optima and are known as acid SMase, alkaline SMase, and neutral SMase (nSMase). Eukaryotic proteins in this family are nSMases, and are activated by a variety of stress-inducing agents such as cytokines or UV radiation. Ceramides and other metabolic derivatives, including sphingosine, are lipid "second messenger" molecules that participate in the regulation of stress-induced cellular responses, including cell death, adhesion, differentiation, and proliferation. Bacterial neutral SMases, which also belong to this family, are secreted proteins that act as membrane-damaging virulence factors. They promote colonization of the host tissue.
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| nSMase | cd09078 | Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological ... |
336-646 | 1.16e-76 | ||||||
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Sphingomyelinases (SMase) are phosphodiesterases that catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Eukaryotic SMases have been classified according to their pH optima and are known as acid SMase, alkaline SMase, and neutral SMase (nSMase). Eukaryotic proteins in this family are nSMases, and are activated by a variety of stress-inducing agents such as cytokines or UV radiation. Ceramides and other metabolic derivatives, including sphingosine, are lipid "second messenger" molecules that participate in the regulation of stress-induced cellular responses, including cell death, adhesion, differentiation, and proliferation. Bacterial neutral SMases, which also belong to this domain family, are secreted proteins that act as membrane-damaging virulence factors. They promote colonization of the host tissue. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. : Pssm-ID: 197312 [Multi-domain] Cd Length: 280 Bit Score: 246.48 E-value: 1.16e-76
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| dermokine super family | cl42387 | dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ... |
172-321 | 2.74e-04 | ||||||
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts. The actual alignment was detected with superfamily member cd21118: Pssm-ID: 455732 [Multi-domain] Cd Length: 495 Bit Score: 43.83 E-value: 2.74e-04
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| Name | Accession | Description | Interval | E-value | ||||||
| nSMase | cd09078 | Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological ... |
336-646 | 1.16e-76 | ||||||
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Sphingomyelinases (SMase) are phosphodiesterases that catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Eukaryotic SMases have been classified according to their pH optima and are known as acid SMase, alkaline SMase, and neutral SMase (nSMase). Eukaryotic proteins in this family are nSMases, and are activated by a variety of stress-inducing agents such as cytokines or UV radiation. Ceramides and other metabolic derivatives, including sphingosine, are lipid "second messenger" molecules that participate in the regulation of stress-induced cellular responses, including cell death, adhesion, differentiation, and proliferation. Bacterial neutral SMases, which also belong to this domain family, are secreted proteins that act as membrane-damaging virulence factors. They promote colonization of the host tissue. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. Pssm-ID: 197312 [Multi-domain] Cd Length: 280 Bit Score: 246.48 E-value: 1.16e-76
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| ElsH | COG3568 | Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ... |
409-510 | 5.39e-06 | ||||||
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only]; Pssm-ID: 442789 [Multi-domain] Cd Length: 167 Bit Score: 46.83 E-value: 5.39e-06
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| Exo_endo_phos | pfam03372 | Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ... |
330-512 | 1.90e-05 | ||||||
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin. Pssm-ID: 460902 [Multi-domain] Cd Length: 183 Bit Score: 45.68 E-value: 1.90e-05
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| dermokine | cd21118 | dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ... |
172-321 | 2.74e-04 | ||||||
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts. Pssm-ID: 411053 [Multi-domain] Cd Length: 495 Bit Score: 43.83 E-value: 2.74e-04
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| Name | Accession | Description | Interval | E-value | ||||||
| nSMase | cd09078 | Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological ... |
336-646 | 1.16e-76 | ||||||
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Sphingomyelinases (SMase) are phosphodiesterases that catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Eukaryotic SMases have been classified according to their pH optima and are known as acid SMase, alkaline SMase, and neutral SMase (nSMase). Eukaryotic proteins in this family are nSMases, and are activated by a variety of stress-inducing agents such as cytokines or UV radiation. Ceramides and other metabolic derivatives, including sphingosine, are lipid "second messenger" molecules that participate in the regulation of stress-induced cellular responses, including cell death, adhesion, differentiation, and proliferation. Bacterial neutral SMases, which also belong to this domain family, are secreted proteins that act as membrane-damaging virulence factors. They promote colonization of the host tissue. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. Pssm-ID: 197312 [Multi-domain] Cd Length: 280 Bit Score: 246.48 E-value: 1.16e-76
|
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| ElsH | COG3568 | Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ... |
409-510 | 5.39e-06 | ||||||
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only]; Pssm-ID: 442789 [Multi-domain] Cd Length: 167 Bit Score: 46.83 E-value: 5.39e-06
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| Exo_endo_phos | pfam03372 | Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ... |
330-512 | 1.90e-05 | ||||||
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin. Pssm-ID: 460902 [Multi-domain] Cd Length: 183 Bit Score: 45.68 E-value: 1.90e-05
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| dermokine | cd21118 | dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ... |
172-321 | 2.74e-04 | ||||||
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts. Pssm-ID: 411053 [Multi-domain] Cd Length: 495 Bit Score: 43.83 E-value: 2.74e-04
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| Blast search parameters | ||||
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