F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124238   253 SWREMFLERPRVRFDGVYISKTTYIRQGeqsldgfYRAW------HQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRT 326
Cdd:pfam19270  11 SWRKMFLERPRLRTDGLYVSRNTYIRAG-------VAEWtvtnpvHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKSMNF 83

                          90       100
                  ....*....|....*....|
gi 13124238   327 RNTRTDA-ILLGHYRLSQDT 345
Cdd:pfam19270  84 RASKADQcVFSGRYTLTGDR 103

F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124238   253 SWREMFLERPRVRFDGVYISKTTYIRQGeqsldgfYRAW------HQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRT 326
Cdd:pfam19270  11 SWRKMFLERPRLRTDGLYVSRNTYIRAG-------VAEWtvtnpvHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKSMNF 83

                          90       100
                  ....*....|....*....|
gi 13124238   327 RNTRTDA-ILLGHYRLSQDT 345
Cdd:pfam19270  84 RASKADQcVFSGRYTLTGDR 103

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 13124238    92 EKARELFLKAVEEEQNGALYEAIKFYRRAMQL 123
Cdd:pfam04212   2 SKALELVKKAVEEDNAGNYEEALELYKEALDY 33

F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124238   253 SWREMFLERPRVRFDGVYISKTTYIRQGeqsldgfYRAW------HQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRT 326
Cdd:pfam19270  11 SWRKMFLERPRLRTDGLYVSRNTYIRAG-------VAEWtvtnpvHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKSMNF 83

                          90       100
                  ....*....|....*....|
gi 13124238   327 RNTRTDA-ILLGHYRLSQDT 345
Cdd:pfam19270  84 RASKADQcVFSGRYTLTGDR 103

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 13124238 190 VLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWRLAC 237
Cdd:cd22087   3 ALPPEIKLRILSL-----LDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 13124238   188 ISVLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWRL 235
Cdd:pfam00646   1 LLDLPDDLLLEILSR-----LDPKDLLRLSLVSKRWRSLVDSLKLWKK 43

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 13124238 188 ISVLPMEVLMYIFrwvvsSDLDLRSLEQLSLVCRGFY-ICARDPEIWRLAC 237
Cdd:cd22113   1 IELLPPEMSLRIF-----SQLDVQSLCRASQTCKTWNdLIENSDYLWRPHC 46

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 13124238 188 ISVLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWR 234
Cdd:cd22093   1 IERLPSEILLKILSY-----LDASSLLCISCVNKLFYQLANDNALWR 42

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 13124238 188 ISVLPMEVLMYIFrwvvsSDLDLRSLEQLSLVCRGFYICARDPEIWRLAC 237
Cdd:cd22147   2 LSALPVELSLKIL-----SYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46

F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 13124238 191 LPMEVLMYIFrwvvsSDLDLRS-LEQLSLVCRGFYICARDPEIWRL 235
Cdd:cd22135   4 LPPELLLHIC-----SYLDARFvLHVLPLVCKTFRDILSDETTWRI 44

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 13124238    92 EKARELFLKAVEEEQNGALYEAIKFYRRAMQL 123
Cdd:pfam04212   2 SKALELVKKAVEEDNAGNYEEALELYKEALDY 33

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 13124238 191 LPMEVLMYIFRwvvSSDLDLRSLEQLSLVCRGFYICARDPEIWRL 235
Cdd:cd22096   4 LPDELLEYILC---SDNLDHHDIIRLSCTCRRLREVCQSGKVWRE 45