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Conserved domains on  [gi|1466335365|gb|RGG95103|]
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TetR/AcrR family transcriptional regulator [Clostridium sp. AF16-25]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ScbR_bind_reg super family cl49260
ScbR family autoregulator-binding transcription factor;
13-65 8.54e-16

ScbR family autoregulator-binding transcription factor;


The actual alignment was detected with superfamily member NF041196:

Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 72.24  E-value: 8.54e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1466335365  13 TRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVE 65
Cdd:NF041196    7 TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLE 59
 
Name Accession Description Interval E-value
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
13-65 8.54e-16

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 72.24  E-value: 8.54e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1466335365  13 TRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVE 65
Cdd:NF041196    7 TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLE 59
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
11-82 1.27e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 1.27e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1466335365  11 KETRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVEPVLEKLKHMLQQHMRQE 82
Cdd:COG1309     5 EATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE 76
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
17-63 3.65e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 56.26  E-value: 3.65e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1466335365  17 LLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAI 63
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 1-65 2.32e-09

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 55.01  E-value: 2.32e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1466335365   1 MERKGARKVEkETRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVE 65
Cdd:PRK10668    1 MARKTKQQAQ-ETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWE 64
 
Name Accession Description Interval E-value
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
13-65 8.54e-16

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 72.24  E-value: 8.54e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1466335365  13 TRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVE 65
Cdd:NF041196    7 TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLE 59
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
11-82 1.27e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 1.27e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1466335365  11 KETRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVEPVLEKLKHMLQQHMRQE 82
Cdd:COG1309     5 EATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE 76
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
17-63 3.65e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 56.26  E-value: 3.65e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1466335365  17 LLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAI 63
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 1-65 2.32e-09

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 55.01  E-value: 2.32e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1466335365   1 MERKGARKVEkETRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVE 65
Cdd:PRK10668    1 MARKTKQQAQ-ETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWE 64
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 6-99 2.76e-07

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 49.35  E-value: 2.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466335365   6 ARKVEKE---TRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIvepvleklkhMLQQHMRQE 82
Cdd:PRK09975    2 AKKTKAEalkTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEM----------WLQQPPLRE 71

                          90
                  ....*....|....*..
gi 1466335365  83 LMELQQLPDAREDNMQD 99
Cdd:PRK09975   72 LIQEHLTAGLEHDPLQQ 88
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
12-94 6.07e-05

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 42.23  E-value: 6.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466335365  12 ETRELLLASAKQEFLEKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVEPVLEKlkhmLQQHMRQELMELQQLPD 91
Cdd:COG3226     8 ERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAER----EAARLRALLAAADDLED 83


                  ...
gi 1466335365  92 ARE 94
Cdd:COG3226    84 AAE 86
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 27-81 4.81e-03

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 36.74  E-value: 4.81e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1466335365  27 EKGYQGASLRSICKNAGVTTGALYFFFQDKEDLFAAIVEPVLEKLKHMLQQHMRQ 81
Cdd:PRK00767   24 EVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQLGDAVLARLAA 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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