NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1467101561|gb|RGO23145|]
View 

DUF3991 domain-containing protein [Dorea sp. OM02-2LB]

Protein Classification

DUF3991 and TOPRIM domain-containing protein( domain architecture ID 10586973)

DUF3991 and toprim (topoisomerase-primase) domain-containing protein may function as a bifunctional DNA primase/helicase

Gene Ontology:  GO:0006260|GO:0003677

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF3991 pfam13154
Protein of unknown function (DUF3991); This family of proteins is often associated with family ...
 120-191 3.82e-12

Protein of unknown function (DUF3991); This family of proteins is often associated with family Toprim, pfam01751.


:

Pssm-ID: 432999  Cd Length: 74  Bit Score: 60.75  E-value: 3.82e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1467101561 120 AYLNH-RGVSDAVITYCISQEILYESvPYHNAVFVGKDESGKARYAFLRGIYEKNGKGFKMEqvGSEKKYSFC 191
Cdd:pfam13154   1 AYLTKqRGIPPEIVRAFIRQDLLYED-PYGNAVFVHYDENGKVTGAEERGTYGKSFKGFVSG--GSKVLFSFG 70
Toprim_2 super family cl48160
Toprim-like; This is a family or Toprim-like proteins.
 203-298 1.43e-03

Toprim-like; This is a family or Toprim-like proteins.


The actual alignment was detected with superfamily member pfam13155:

Pssm-ID: 463793 [Multi-domain]  Cd Length: 88  Bit Score: 37.16  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467101561 203 VYEACIDALAhmTLEEGKQDKYRLSLGGIAAPKENAQIqserfkkppdaleafLKNHPeiKEIEICTDNDFAGRWAKEQM 282
Cdd:pfam13155   2 VFEGYIDALS--LAQAGIKNVLYVATLGTALTEAQIKL---------------LKRYP--KEVILAFDNDEAGRKAAKRL 62

                          90
                  ....*....|....*...
gi 1467101561 283 KKHYEGRY--KIICNLPE 298
Cdd:pfam13155  63 AELLKEAGvdVKIRLLPD 80
 
Name Accession Description Interval E-value
DUF3991 pfam13154
Protein of unknown function (DUF3991); This family of proteins is often associated with family ...
 120-191 3.82e-12

Protein of unknown function (DUF3991); This family of proteins is often associated with family Toprim, pfam01751.


Pssm-ID: 432999  Cd Length: 74  Bit Score: 60.75  E-value: 3.82e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1467101561 120 AYLNH-RGVSDAVITYCISQEILYESvPYHNAVFVGKDESGKARYAFLRGIYEKNGKGFKMEqvGSEKKYSFC 191
Cdd:pfam13154   1 AYLTKqRGIPPEIVRAFIRQDLLYED-PYGNAVFVHYDENGKVTGAEERGTYGKSFKGFVSG--GSKVLFSFG 70
Toprim_2 pfam13155
Toprim-like; This is a family or Toprim-like proteins.
 203-298 1.43e-03

Toprim-like; This is a family or Toprim-like proteins.


Pssm-ID: 463793 [Multi-domain]  Cd Length: 88  Bit Score: 37.16  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467101561 203 VYEACIDALAhmTLEEGKQDKYRLSLGGIAAPKENAQIqserfkkppdaleafLKNHPeiKEIEICTDNDFAGRWAKEQM 282
Cdd:pfam13155   2 VFEGYIDALS--LAQAGIKNVLYVATLGTALTEAQIKL---------------LKRYP--KEVILAFDNDEAGRKAAKRL 62

                          90
                  ....*....|....*...
gi 1467101561 283 KKHYEGRY--KIICNLPE 298
Cdd:pfam13155  63 AELLKEAGvdVKIRLLPD 80
 
Name Accession Description Interval E-value
DUF3991 pfam13154
Protein of unknown function (DUF3991); This family of proteins is often associated with family ...
 120-191 3.82e-12

Protein of unknown function (DUF3991); This family of proteins is often associated with family Toprim, pfam01751.


Pssm-ID: 432999  Cd Length: 74  Bit Score: 60.75  E-value: 3.82e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1467101561 120 AYLNH-RGVSDAVITYCISQEILYESvPYHNAVFVGKDESGKARYAFLRGIYEKNGKGFKMEqvGSEKKYSFC 191
Cdd:pfam13154   1 AYLTKqRGIPPEIVRAFIRQDLLYED-PYGNAVFVHYDENGKVTGAEERGTYGKSFKGFVSG--GSKVLFSFG 70
Toprim_2 pfam13155
Toprim-like; This is a family or Toprim-like proteins.
 203-298 1.43e-03

Toprim-like; This is a family or Toprim-like proteins.


Pssm-ID: 463793 [Multi-domain]  Cd Length: 88  Bit Score: 37.16  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467101561 203 VYEACIDALAhmTLEEGKQDKYRLSLGGIAAPKENAQIqserfkkppdaleafLKNHPeiKEIEICTDNDFAGRWAKEQM 282
Cdd:pfam13155   2 VFEGYIDALS--LAQAGIKNVLYVATLGTALTEAQIKL---------------LKRYP--KEVILAFDNDEAGRKAAKRL 62

                          90
                  ....*....|....*...
gi 1467101561 283 KKHYEGRY--KIICNLPE 298
Cdd:pfam13155  63 AELLKEAGvdVKIRLLPD 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH