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Conserved domains on  [gi|1470777125|gb|RHB80826|]
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UDP-N-acetylmuramate dehydrogenase [Bifidobacterium pseudocatenulatum]

Protein Classification

UDP-N-acetylmuramate dehydrogenase( domain architecture ID 1562441)

UDP-N-acetylmuramate dehydrogenase is responsible for the synthesis of UDP-N-acetylmuramic acid in bacterial cell wall biosynthesis

CATH:  3.30.43.10|3.90.78.10|3.30.465.10
EC:  1.3.1.98
Gene Ontology:  GO:0009252|GO:0008762
SCOP:  4002184|4002195

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
murB super family cl46907
UDP-N-acetylmuramate dehydrogenase;
1-398 1.10e-130

UDP-N-acetylmuramate dehydrogenase;


The actual alignment was detected with superfamily member PRK13903:

Pssm-ID: 481247 [Multi-domain]  Cd Length: 363  Bit Score: 379.69  E-value: 1.10e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   1 MTNFADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARHAVSVldeaapvE 80
Cdd:PRK13903   18 DVPLAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDGFDGTVVRVATRGVTV-------D 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  81 NGETIVHvnAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNKQTKELTNQD 160
Cdd:PRK13903   91 CGGGLVR--AEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLLDRRTGEVRWVPAAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 161 LHFGYRMSALKASMysapatpaadffptpRYVVLSVTFALHHSETGV-VGYGQLAKALGVEVGDRMATADIRNAVLKVRA 239
Cdd:PRK13903  169 LGFGYRTSVLKHSD---------------RAVVLEVEFQLDPSGLSApLRYGELARALGVEPGERVPPAAVREAVLALRA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 240 SKGMLEdshrylteamrgtkkselvaiahdaqrtqtgnDEPDYNRHSCGSFFMNPILTKEQAAKLPEDA--------PRF 311
Cdd:PRK13903  234 GKGMVL--------------------------------DPADHDTWSAGSFFTNPVVSPAVAERLAARVaerlgdpvPRY 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 312 datlPDGTPGVKTSAAWLIDHAGFHKGYKtSENATAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEP 391
Cdd:PRK13903  282 ----PAGDGGVKLSAAWLIERAGFGKGYP-GGGAPARLSTKHTLALTNRGGATTADLVALAREVRDGVRDAFGVTLVPEP 356


                  ....*..
gi 1470777125 392 VIIGMSL 398
Cdd:PRK13903  357 VLVGCSL 363
 
Name Accession Description Interval E-value
murB PRK13903
UDP-N-acetylmuramate dehydrogenase;
1-398 1.10e-130

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237552 [Multi-domain]  Cd Length: 363  Bit Score: 379.69  E-value: 1.10e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   1 MTNFADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARHAVSVldeaapvE 80
Cdd:PRK13903   18 DVPLAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDGFDGTVVRVATRGVTV-------D 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  81 NGETIVHvnAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNKQTKELTNQD 160
Cdd:PRK13903   91 CGGGLVR--AEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLLDRRTGEVRWVPAAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 161 LHFGYRMSALKASMysapatpaadffptpRYVVLSVTFALHHSETGV-VGYGQLAKALGVEVGDRMATADIRNAVLKVRA 239
Cdd:PRK13903  169 LGFGYRTSVLKHSD---------------RAVVLEVEFQLDPSGLSApLRYGELARALGVEPGERVPPAAVREAVLALRA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 240 SKGMLEdshrylteamrgtkkselvaiahdaqrtqtgnDEPDYNRHSCGSFFMNPILTKEQAAKLPEDA--------PRF 311
Cdd:PRK13903  234 GKGMVL--------------------------------DPADHDTWSAGSFFTNPVVSPAVAERLAARVaerlgdpvPRY 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 312 datlPDGTPGVKTSAAWLIDHAGFHKGYKtSENATAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEP 391
Cdd:PRK13903  282 ----PAGDGGVKLSAAWLIERAGFGKGYP-GGGAPARLSTKHTLALTNRGGATTADLVALAREVRDGVRDAFGVTLVPEP 356


                  ....*..
gi 1470777125 392 VIIGMSL 398
Cdd:PRK13903  357 VLVGCSL 363
MurB COG0812
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ...
 5-394 1.26e-99

UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440574 [Multi-domain]  Cd Length: 279  Bit Score: 297.31  E-value: 1.26e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   5 ADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDAR-HAVSVLDEaapvenge 83
Cdd:COG0812     4 APHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDGFDGLVIRLGRlKGIEVDDG-------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  84 tiVHVNAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRkNKQTKELTNQDLHF 163
Cdd:COG0812    76 --VLVTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLDR-TGEVRTLSAEECGF 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 164 GYRMSALKASmysapatpaadffptpRYVVLSVTFALHHsetgvvgygqlakalgvevGDRMATADIRNAVLKVRASKgm 243
Cdd:COG0812   153 GYRDSIFKRE----------------RYIILSVTFRLKK-------------------GDPAEIAAVMDAVLAIRRSK-- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 244 ledshrylteamrgtkkselvaiahdaQRTQTGNdepdynrhsCGSFFMNPiltkeqaaklpedaprfdatlpdgtPGvk 323
Cdd:COG0812   196 ---------------------------QPLELPS---------AGSFFKNP-------------------------PG-- 212

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1470777125 324 TSAAWLIDHAGFhKGYKTSEnatAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVII 394
Cdd:COG0812   213 DSAGWLIEQAGL-KGYRIGG---AQVSEKHANFLVNRGGATAADVLALIEEVQARVKEKFGVELEPEVRII 279
murB TIGR00179
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ...
 5-395 1.58e-40

UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 272945 [Multi-domain]  Cd Length: 284  Bit Score: 145.29  E-value: 1.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   5 ADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARHAVSVLDEAApvenget 84
Cdd:TIGR00179   2 AEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINLGKGIDIEDDEGE------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  85 IVHVNAeaGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNKqTKELTNQDLHFG 164
Cdd:TIGR00179  75 YVHVGG--GENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATILLATGK-TEWLTNEQLGFG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 165 YRMSALKasmysapatpaadffptpryvvlsvtfalhHSETGVvgygqlakalgvevgdrmatadirnaVLKVRaskgmL 244
Cdd:TIGR00179 152 YRTSIFQ------------------------------HKYVGL--------------------------VLKAE-----F 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 245 EDSHRYLTEAMRGTKKSELVAIAHDAQRTQtgndepDYNRHSCGSFFMNPiltkeqaaklpedaprfdatLPDgtpgvkt 324
Cdd:TIGR00179 171 QLTLGFGTRLDPETITAQQVFNKVCRMRTS------HYPDPNAGSFFKNP--------------------SPN------- 217

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1470777125 325 SAAWLIDHAGFhKGYKTsenATAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVIIG 395
Cdd:TIGR00179 218 HAGRLIEECGL-KGYQI---GGAAVSKQHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEPEVKIIG 284
MurB_C pfam02873
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ...
 286-394 2.49e-28

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 460730 [Multi-domain]  Cd Length: 99  Bit Score: 106.67  E-value: 2.49e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 286 SCGSFFMNPiltkeqaaklpedaprfdatlpdgtpgVKTSAAWLIDHAGFhKGYktSENAtAGLSTMHTLALTNRGGASA 365
Cdd:pfam02873  22 SAGSFFKNP---------------------------VGHSAGWLIEQAGL-KGY--RIGG-AQVSEKHANFLVNTGGATA 70

                          90       100
                  ....*....|....*....|....*....
gi 1470777125 366 ADIVRLAKTVQDGVERAYGIRLVPEPVII 394
Cdd:pfam02873  71 ADVLALIEEVRERVKEKFGVELEPEVRII 99
 
Name Accession Description Interval E-value
murB PRK13903
UDP-N-acetylmuramate dehydrogenase;
1-398 1.10e-130

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237552 [Multi-domain]  Cd Length: 363  Bit Score: 379.69  E-value: 1.10e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   1 MTNFADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARHAVSVldeaapvE 80
Cdd:PRK13903   18 DVPLAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDGFDGTVVRVATRGVTV-------D 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  81 NGETIVHvnAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNKQTKELTNQD 160
Cdd:PRK13903   91 CGGGLVR--AEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLLDRRTGEVRWVPAAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 161 LHFGYRMSALKASMysapatpaadffptpRYVVLSVTFALHHSETGV-VGYGQLAKALGVEVGDRMATADIRNAVLKVRA 239
Cdd:PRK13903  169 LGFGYRTSVLKHSD---------------RAVVLEVEFQLDPSGLSApLRYGELARALGVEPGERVPPAAVREAVLALRA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 240 SKGMLEdshrylteamrgtkkselvaiahdaqrtqtgnDEPDYNRHSCGSFFMNPILTKEQAAKLPEDA--------PRF 311
Cdd:PRK13903  234 GKGMVL--------------------------------DPADHDTWSAGSFFTNPVVSPAVAERLAARVaerlgdpvPRY 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 312 datlPDGTPGVKTSAAWLIDHAGFHKGYKtSENATAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEP 391
Cdd:PRK13903  282 ----PAGDGGVKLSAAWLIERAGFGKGYP-GGGAPARLSTKHTLALTNRGGATTADLVALAREVRDGVRDAFGVTLVPEP 356


                  ....*..
gi 1470777125 392 VIIGMSL 398
Cdd:PRK13903  357 VLVGCSL 363
MurB COG0812
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ...
 5-394 1.26e-99

UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440574 [Multi-domain]  Cd Length: 279  Bit Score: 297.31  E-value: 1.26e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   5 ADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDAR-HAVSVLDEaapvenge 83
Cdd:COG0812     4 APHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDGFDGLVIRLGRlKGIEVDDG-------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  84 tiVHVNAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRkNKQTKELTNQDLHF 163
Cdd:COG0812    76 --VLVTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLDR-TGEVRTLSAEECGF 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 164 GYRMSALKASmysapatpaadffptpRYVVLSVTFALHHsetgvvgygqlakalgvevGDRMATADIRNAVLKVRASKgm 243
Cdd:COG0812   153 GYRDSIFKRE----------------RYIILSVTFRLKK-------------------GDPAEIAAVMDAVLAIRRSK-- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 244 ledshrylteamrgtkkselvaiahdaQRTQTGNdepdynrhsCGSFFMNPiltkeqaaklpedaprfdatlpdgtPGvk 323
Cdd:COG0812   196 ---------------------------QPLELPS---------AGSFFKNP-------------------------PG-- 212

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1470777125 324 TSAAWLIDHAGFhKGYKTSEnatAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVII 394
Cdd:COG0812   213 DSAGWLIEQAGL-KGYRIGG---AQVSEKHANFLVNRGGATAADVLALIEEVQARVKEKFGVELEPEVRII 279
murB PRK00046
UDP-N-acetylmuramate dehydrogenase;
17-394 3.16e-86

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 234593 [Multi-domain]  Cd Length: 334  Bit Score: 265.09  E-value: 3.16e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  17 ASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTpFDGVVVRDARHAVSVLDEaapvenGETIVHVNAEAGCNW 96
Cdd:PRK00046   22 RHLVEAESEEQLLEALADARAAGLPVLVLGGGSNVLFTED-FDGTVLLNRIKGIEVLSE------DDDAWYLHVGAGENW 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  97 DDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNKQTKELTNQDLHFGYRMSALKASMYS 176
Cdd:PRK00046   95 HDLVLWTLQQGMPGLENLALIPGTVGAAPIQNIGAYGVELKDVCDYVEALDLATGEFVRLSAAECRFGYRDSIFKHEYPD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 177 apatpaadffptpRYVVLSVTFALHHSETGVVGYGQLAKALGVEVGdrmaTADIRNAVLKVRASKgmLEDSHrylteamr 256
Cdd:PRK00046  175 -------------RYAITAVGFRLPKQWQPVLDYGDLARLDPDTVT----AQDVFDAVCAIRRSK--LPDPK-------- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 257 gtkkselvaiahdaqrtQTGNdepdynrhsCGSFFMNPILTKEQAAKL----PeDAPRFdaTLPDGTpgVKTSAAWLIDH 332
Cdd:PRK00046  228 -----------------VLGN---------AGSFFKNPVVSAEQFEALlaqyP-DIPHY--PQADGS--VKLAAGWLIDQ 276

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1470777125 333 AGFhKGYktSENAtAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVII 394
Cdd:PRK00046  277 CGL-KGF--QIGG-AAVHEKQALVLVNYGNATGADVLALARHIQQDVREKFGVELEPEPRFI 334
murB PRK13905
UDP-N-acetylmuramate dehydrogenase;
5-395 4.04e-53

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237553 [Multi-domain]  Cd Length: 298  Bit Score: 178.38  E-value: 4.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   5 ADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARhavsVLDEAAPveNGET 84
Cdd:PRK13905   20 ARYTSFRVGGPADYLVEPADIEDLQEFLKLLKENNIPVTVLGNGSNLLVRDGGIRGVVIRLGK----GLNEIEV--EGNR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  85 IVhvnAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNkQTKELTNQDLHFG 164
Cdd:PRK13905   94 IT---AGAGAPLIKLARFAAEAGLSGLEFAAGIPGTVGGAVFMNAGAYGGETADVLESVEVLDRDG-EIKTLSNEELGFG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 165 YRMSALkasmysapatpaadffPTPRYVVLSVTFALHHsetgvvgygqlakalgvevGDRmatADIRNAVLKVRAskgml 244
Cdd:PRK13905  170 YRHSAL----------------QEEGLIVLSATFQLEP-------------------GDK---EEIKARMDELLA----- 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 245 edsHRylteamrgtkkselvaiahdaQRTQtgndePdYNRHSCGSFFMNPiltkeqaaklpedaprfdatlpdgtPGvkT 324
Cdd:PRK13905  207 ---RR---------------------EATQ-----P-LEYPSAGSVFKNP-------------------------PG--H 229

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1470777125 325 SAAWLIDHAGFhKGYKtseNATAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVIIG 395
Cdd:PRK13905  230 FAGKLIEEAGL-KGYR---IGGAQVSEKHANFIINTGGATAADIEDLIEHVQKTVKEKFGVELEWEVRIIG 296
murB TIGR00179
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ...
 5-395 1.58e-40

UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 272945 [Multi-domain]  Cd Length: 284  Bit Score: 145.29  E-value: 1.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   5 ADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARHAVSVLDEAApvenget 84
Cdd:TIGR00179   2 AEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINLGKGIDIEDDEGE------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  85 IVHVNAeaGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNKqTKELTNQDLHFG 164
Cdd:TIGR00179  75 YVHVGG--GENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATILLATGK-TEWLTNEQLGFG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 165 YRMSALKasmysapatpaadffptpryvvlsvtfalhHSETGVvgygqlakalgvevgdrmatadirnaVLKVRaskgmL 244
Cdd:TIGR00179 152 YRTSIFQ------------------------------HKYVGL--------------------------VLKAE-----F 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 245 EDSHRYLTEAMRGTKKSELVAIAHDAQRTQtgndepDYNRHSCGSFFMNPiltkeqaaklpedaprfdatLPDgtpgvkt 324
Cdd:TIGR00179 171 QLTLGFGTRLDPETITAQQVFNKVCRMRTS------HYPDPNAGSFFKNP--------------------SPN------- 217

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1470777125 325 SAAWLIDHAGFhKGYKTsenATAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVIIG 395
Cdd:TIGR00179 218 HAGRLIEECGL-KGYQI---GGAAVSKQHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEPEVKIIG 284
PRK14649 PRK14649
UDP-N-acetylmuramate dehydrogenase;
5-395 2.51e-34

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173112 [Multi-domain]  Cd Length: 295  Bit Score: 128.81  E-value: 2.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   5 ADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARHAVSVldeaapVENGET 84
Cdd:PRK14649   10 APYTSWRIGGPARYFVEPTTPDEAIAAAAWAEQRQLPLFWLGGGSNLLVRDEGFDGLVARYRGQRWEL------HEHGDT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  85 I-VHVnaEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNkQTKELTNQDLHF 163
Cdd:PRK14649   84 AeVWV--EAGAPMAGTARRLAAQGWAGLEWAEGLPGTIGGAIYGNAGCYGGDTATVLIRAWLLLNGS-ECVEWSVHDFAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 164 GYRMSALKasmysapaTPAADFFPTPRYVVLSVTFALHhsetgvvgygqlakalgvevgdrmatadirnavlkvraskgm 243
Cdd:PRK14649  161 GYRTSVLK--------QLRADGITWRPPLVLAARFRLH------------------------------------------ 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 244 lEDSHRYLTEAMRGTKkselvaiAHDAQRTQTGNdepdynrhSCGSFFMNPiltkeqaaklpedaprfdatlpdgtPGvk 323
Cdd:PRK14649  191 -RDDPTALAARMEAIA-------AERKQKTPAGS--------SCGSVFKNP-------------------------PG-- 227

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1470777125 324 TSAAWLIDHAGFhKGYKTSEnatAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVIIG 395
Cdd:PRK14649  228 DSAGRLIEAAGL-KGTRIGD---AEIATRHANYIINLGGARAADILRLIDLARTRVLAQFGIELELEVRIIG 295
MurB_C pfam02873
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ...
 286-394 2.49e-28

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 460730 [Multi-domain]  Cd Length: 99  Bit Score: 106.67  E-value: 2.49e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 286 SCGSFFMNPiltkeqaaklpedaprfdatlpdgtpgVKTSAAWLIDHAGFhKGYktSENAtAGLSTMHTLALTNRGGASA 365
Cdd:pfam02873  22 SAGSFFKNP---------------------------VGHSAGWLIEQAGL-KGY--RIGG-AQVSEKHANFLVNTGGATA 70

                          90       100
                  ....*....|....*....|....*....
gi 1470777125 366 ADIVRLAKTVQDGVERAYGIRLVPEPVII 394
Cdd:pfam02873  71 ADVLALIEEVRERVKEKFGVELEPEVRII 99
PRK14653 PRK14653
UDP-N-acetylmuramate dehydrogenase;
5-171 4.54e-18

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237778 [Multi-domain]  Cd Length: 297  Bit Score: 83.73  E-value: 4.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   5 ADLTTIAVGGPIASFIEPTSRVGVIEAVeDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARhavsvLDEAApVENGET 84
Cdd:PRK14653   23 KCHVSFKIGGPVPLFAIPNSTNGFIETI-NLLKEGIEVKILGNGTNVLPKDEPMDFVVVSTER-----LDDIF-VDNDKI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  85 IVhvnaEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDrkNKQTKELTNQDLHFG 164
Cdd:PRK14653   96 IC----ESGLSLKKLCLVAAKNGLSGFENAYGIPGSVGGAVYMNAGAYGWETAENIVEVVAYD--GKKIIRLGKNEIKFS 169


                  ....*..
gi 1470777125 165 YRMSALK 171
Cdd:PRK14653  170 YRNSIFK 176
FAD_binding_4 pfam01565
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most ...
 19-147 4.27e-17

FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 426326 [Multi-domain]  Cd Length: 139  Bit Score: 77.24  E-value: 4.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  19 FIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRdarhaVSVLDEAAPVENGETIVHVnaEAGCNWDD 98
Cdd:pfam01565   4 VVLPESEEEVAAIVRLANENGLPVLPRGGGSSLLGGAVQTGGIVLD-----LSRLNGILEIDPEDGTATV--EAGVTLGD 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1470777125  99 FVDYCVNLGLE-GVEGLSGIPGTVGASVVQNIGAYGQE----VASSVESVEVWD 147
Cdd:pfam01565  77 LVRALAAKGLLlGLDPGSGIPGTVGGAIATNAGGYGSEkyglTRDNVLGLEVVL 130
PRK12436 PRK12436
UDP-N-acetylmuramate dehydrogenase;
8-399 9.39e-16

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 171497 [Multi-domain]  Cd Length: 305  Bit Score: 77.36  E-value: 9.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   8 TTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDAR-HAVSVLDEAAPVENGETIV 86
Cdd:PRK12436   29 THIKVGGKADVFVAPTNYDEIQEVIKYANKYNIPVTFLGNGSNVIIKDGGIRGITVSLIHiTGVTVTGTTIVAQCGAAII 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  87 HVNAEAgcnwddfVDYCvnlgLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDrKNKQTKELTNQDLHFGYR 166
Cdd:PRK12436  109 DVSRIA-------LDHN----LTGLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMT-GDGELRTLTKEAFEFGYR 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 167 MSAlkasmysapatpaadfFPTPRYVVLSVTFalhhsetgvvgygQLAKALGVEVGDRMATADIRnavlkvRASKGMLEd 246
Cdd:PRK12436  177 KSV----------------FANNHYIILEARF-------------ELEEGVYEEIKAKMDDLTFK------RESKQPLE- 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 247 shrylteamrgtkkselvaiahdaqrtqtgndepdynRHSCGSFFMNPilTKEQAAKLPEDAprfdatlpdGTPGVKTSA 326
Cdd:PRK12436  221 -------------------------------------YPSCGSVFKRP--PNNFAGKLIQES---------GLQGKRIGG 252

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1470777125 327 AWL-IDHAGFhkgyktsenataglstmhtlaLTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVIIGMSLK 399
Cdd:PRK12436  253 VEVsLKHAGF---------------------MVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRIIGEDKE 305
PRK14651 PRK14651
UDP-N-acetylmuramate dehydrogenase;
5-170 1.09e-14

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237776 [Multi-domain]  Cd Length: 273  Bit Score: 73.70  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   5 ADLTTIAVGGPiasfieptSRVGVIEAVED-ADAKGLPLCVIGGGSNMLVADTpfdGVVVRdarhavsVLDEAAPVENGE 83
Cdd:PRK14651   10 ARYTTLGVGGP--------AELWTVETHEQlAEATEAPYRVLGGGSNLLVSDA---GVPER-------VIRLGGEFAEWD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  84 TIVHVNAeaGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWdrKNKQTKELTNQDLHF 163
Cdd:PRK14651   72 LDGWVGG--GVPLPGLVRRAARLGLSGLEGLVGIPAQVGGAVKMNAGTRFGEMADALHTVEIV--HDGGFHQYSPDELGF 147


                  ....*..
gi 1470777125 164 GYRMSAL 170
Cdd:PRK14651  148 GYRHSGL 154
PRK14652 PRK14652
UDP-N-acetylmuramate dehydrogenase;
4-395 4.20e-12

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237777 [Multi-domain]  Cd Length: 302  Bit Score: 66.43  E-value: 4.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   4 FADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARhavsvlDEAAPVENGE 83
Cdd:PRK14652   24 LAPRTAVRVGGPADLLVRPADPDALSALLRAVRELGVPLSILGGGANTLVADAGVRGVVLRLPQ------DFPGESTDGG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  84 TIVhvnAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVwdRKNKQTKELTNQDLHF 163
Cdd:PRK14652   98 RLV---LGAGAPISRLPARAHAHGLVGMEFLAGIPGTLGGAVAMNAGTKLGEMKDVVTAVEL--ATADGAGFVPAAALGY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 164 GYRMSALKasmysapatpaadffptPRYVVLSVTFALHHsetgvvgygqlakalgvevGDrmatadirnavlkVRASKGM 243
Cdd:PRK14652  173 AYRTCRLP-----------------PGAVITRVEVRLRP-------------------GD-------------VAASEAL 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 244 LedshryltEAMRGTKKselvaiahdaqRTQTgNDEPDYnrhscGSFFMNPiltkeqaaklpedaprfdatlpdgtPGvk 323
Cdd:PRK14652  204 M--------RADRERRR-----------RTQP-LDRPTF-----GSTFTNP-------------------------PG-- 231

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1470777125 324 TSAAWLIDHAGFhKGYKTsenATAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEPVIIG 395
Cdd:PRK14652  232 DYAGRLVEAVGL-KGHRV---GGAIWSPVHANFVTNLGGATARDVLALVRLARARVKERFGIALETEVRLLG 299
PRK14648 PRK14648
UDP-N-acetylmuramate dehydrogenase;
4-142 1.21e-11

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173111 [Multi-domain]  Cd Length: 354  Bit Score: 65.52  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   4 FADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVrDARHAVSVLDEAApvENGE 83
Cdd:PRK14648   18 LAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLML-SLRRFRSLHTQTQ--RDGS 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1470777125  84 TIVHvnAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVES 142
Cdd:PRK14648   95 VLVH--AGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAAYMNARCYGRAIADCFHS 151
murB PRK13906
UDP-N-acetylmuramate dehydrogenase;
8-168 7.57e-11

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 184386 [Multi-domain]  Cd Length: 307  Bit Score: 62.53  E-value: 7.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   8 TTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRD-ARHAVSVLDEAAPVENGETIV 86
Cdd:PRK13906   29 TYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLlSLDHIEVSDDAIIAGSGAAII 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  87 HVNAEAGcnwddfvDYcvnlGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNKQTKeLTNQDLHFGYR 166
Cdd:PRK13906  109 DVSRVAR-------DY----ALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIK-LTTKELELDYR 176


                  ..
gi 1470777125 167 MS 168
Cdd:PRK13906  177 NS 178
PRK14650 PRK14650
UDP-N-acetylmuramate dehydrogenase;
2-168 3.92e-09

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173113 [Multi-domain]  Cd Length: 302  Bit Score: 57.55  E-value: 3.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   2 TNFADLTTIAVGGPIASFIEPTSRVGVIEAVEDADAKGLPLCVIGGGSNMLVADTPFDGVVVRDARHavsvLDEAAPVEN 81
Cdd:PRK14650   19 KNLANYTTYKIGGISKLFLTPKTIKDAEHIFKAAIEEKIKIFILGGGSNILINDEEEIDFPIIYTGH----LNKIEIHDN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  82 getivHVNAEAGCNWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVWDRKNKQT-KELTNQD 160
Cdd:PRK14650   95 -----QIVAECGTNFEDLCKFALQNELSGLEFIYGLPGTLGGAIWMNARCFGNEISEILDKITFIDEKGKTIcKKFKKEE 169


                  ....*...
gi 1470777125 161 lhFGYRMS 168
Cdd:PRK14650  170 --FKYKIS 175
murB PRK13904
UDP-N-acetylmuramate dehydrogenase;
3-394 1.60e-08

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 184384 [Multi-domain]  Cd Length: 257  Bit Score: 54.93  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125   3 NFADLTTIAVGGPIasfieptsRVGVIEAVEDADAKGLplcVIGGGSNMLVADTP---------FDGVVvrdarhavsvl 73
Cdd:PRK13904    6 DFSKYSSVKIGPPL--------EVLVLEEIDDFSQDGQ---IIGGANNLLISPNPknlailgknFDYIK----------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125  74 deaapvENGETIvhvnaEAGC--NWDDFVDYCVNLGLEGVEGLSGIPGTVGASVVQNIGAYGQEVASSVESVEVwdrkNK 151
Cdd:PRK13904   64 ------IDGECL-----EIGGatKSGKIFNYAKKNNLGGFEFLGKLPGTLGGLVKMNAGLKEYEISNNLESICT----NG 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 152 QTKEltNQDLHFGYRMSALKAsmysapatpaadffptpryVVLSVTFALHHsetgvvGYgqlakalgvevgdrmatadiR 231
Cdd:PRK13904  129 GWIE--KEDIGFGYRSSGING-------------------VILEARFKKTH------GF--------------------D 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 232 NAVLKvraskgmledshryLTEAMRGTKKSElvaiahdaqrtqtgndepdynrHSCGSFFMNPiltkeqaaklPEDaprf 311
Cdd:PRK13904  162 EELLE--------------AFKSMRKNQPKG----------------------PSFGSCFKNP----------KGD---- 191

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470777125 312 datlpdgtpgvktSAAWLIDHAGFhKGYKTSEnatAGLSTMHTLALTNRGGASAADIVRLAKTVQDGVERAYGIRLVPEP 391
Cdd:PRK13904  192 -------------YAGRLIEAVGL-KGYCKGG---AGFSEEHANFLVNLGGATFEDALDLIELAKKRVLEEFGINLEEEV 254


                  ...
gi 1470777125 392 VII 394
Cdd:PRK13904  255 IIL 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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