|
Name |
Accession |
Description |
Interval |
E-value |
| Na_Pro_sym |
TIGR02121 |
sodium/proline symporter; This family consists of the sodium/proline symporter (proline ... |
16-510 |
0e+00 |
|
sodium/proline symporter; This family consists of the sodium/proline symporter (proline permease) from a number of Gram-negative and Gram-positive bacteria and from the archaeal genus Methanosarcina. Using the related pantothenate permease as an outgroup, candidate sequences from Bifidobacterium longum and several from archaea are found to be outside the clade defined by known proline permeases. These sequences, scoring between 570 and -40, define the range between trusted and noise cutoff scores. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273981 Cd Length: 487 Bit Score: 724.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 16 WQTYIMIGVYFVILIVIGFYGYKQATgNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLT 95
Cdd:TIGR02121 1 TEILITFGVYLIIMLLIGFYAYKKTT-NLSDYVLGGRSLGPFVTALSAGASDMSGWLLMGLPGALYVTGLSELWIAIGLT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 96 LGAYINYFVVAPRLRVYTELAGDAITLPDFFKNRLNDKNNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFG 175
Cdd:TIGR02121 80 IGAYINWKFVAPRLRVYTEAAHNSITLPDFFENRFNDKSRLLRIISALIILVFFTIYTSSGLVAGGKLFESTFGLDYKTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 176 LILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWG-TFHDVAAMKPTNLNLFKGLSFIGIISLFS 254
Cdd:TIGR02121 160 LLIGALIIVIYTFFGGFLAVSWTDFVQGLLMFFALVLVPIVALFNLGGFGeTLSAVAAINPHLLDMFKGASVIAIISLLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 255 WGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAY-HIKLEDPETLFIVMSQVLFHPLV 333
Cdd:TIGR02121 240 WGLGYFGQPHIIVRFMAIRSHKELPKARRIGMSWMILSLLGAIAVGLTGIAYFNKNpHVELVDRETIFIVLSQILFHPWI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 334 GGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKaktHQKEFVMVGRLSVLVVAIVAISIAWNPNDTILNLVGN 413
Cdd:TIGR02121 320 AGILLAAILAAIMSTISSQLLVSSSALTEDFYKAFFKREA---SQKELVMVGRLSVLVIAIIAIILAMNPNSSILNLVGY 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 414 AWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWIawikplAHINEIFGLYEIIPGFIVSVIVTYVVSKLTKK 493
Cdd:TIGR02121 397 AWAGFGAAFGPVVLFSLYWKRMTRNGALAGMIIGAVTVIVWI------SKLGGSFGLYEIVPGFIISSIVIVVVSKLTKA 470
|
490
....*....|....*..
gi 1105943496 494 PGAFVETDLNKVRDIVR 510
Cdd:TIGR02121 471 PPAAVQTVFEKAKKLVK 487
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
19-490 |
0e+00 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 573.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFYGYKqATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGA 98
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYR-KTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 99 YINYFVVAPRLRVYTElAGDAITLPDFFKNRLNDKNNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLIL 178
Cdd:cd11475 80 YLNWLFVAKRLRRYTE-KNDSITLPDYLENRFRDKSKLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 179 VAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGW-GTFHDVAAMKPTNLNLFKG----LSFIGIISLF 253
Cdd:cd11475 159 GAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLsGLVAALAAIDPGLLSPFGGdlgaGGLLAIISLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 254 SWGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAyhIKLEDPETLFIVMSQVLFHPLV 333
Cdd:cd11475 239 AWGLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFPD--GLLGDPETVFPVLAQELFPPWL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 334 GGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRgeeKAKTHQKEFVMVGRLSVLVVAIVAISIAWNPNDTILNLVGN 413
Cdd:cd11475 317 AGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFL---RKEASDKELVWVSRLAVLVIALIALLIALNPPSSVFSLVSF 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1105943496 414 AWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWIAWIKplahinEIFGLYEIIPGFIVSVIVTYVVSKL 490
Cdd:cd11475 394 AWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVVVWKLLGL------GIFGLYEIVPGFLASLLAIVVVSLL 464
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
24-496 |
2.73e-147 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 431.75 E-value: 2.73e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 24 VYFVILIVIGFYGYKqATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGAYINYF 103
Cdd:PRK15419 13 VYIFGMILIGFIAWR-STKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGAWINWK 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 104 VVAPRLRVYTELAGDAITLPDFFKNRLNDKNNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILVAFIV 183
Cdd:PRK15419 92 LVAGRLRVHTEYNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAAT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 184 IFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMKPT-NLNLFKGLSFIGIISLFSWGLGYFGQ 262
Cdd:PRK15419 172 ILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSLEVIKQKSIeNVDMLKGLNFVAIISLMGWGLGYFGQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 263 PHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFV---PAYHIKL-EDPETLFIVMSQVLFHPLVGGFLL 338
Cdd:PRK15419 252 PHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFnehPAVAGAVnQNAERVFIELAQILFNPWIAGILL 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 339 AAILAAIMSTISSQLLVTSSSLTEDFYKLIRgeeKAKTHQKEFVMVGRLSVLVVAIVAISIAWNPNDTILNLVGNAWAGF 418
Cdd:PRK15419 332 SAILAAVMSTLSCQLLVCSSAITEDLYKAFL---RKHASQKELVWVGRVMVLVVALVAIALAANPENRVLGLVSYAWAGF 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 419 GASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIW--IAWikplahineiFGLYEIIPGFIVSVIVTYVVSKLTKKPGA 496
Cdd:PRK15419 409 GAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIVWkqFGW----------LGLYEIIPGFIFGSIGIVVFSLLGKAPSA 478
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
15-502 |
4.34e-128 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 381.47 E-value: 4.34e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 15 NWQTYIMIGVYFVILIVIGFYGYKQaTGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGL 94
Cdd:COG0591 2 STLDLIIIILYLLLLLGIGLYASRR-TKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 95 TLGAYINYFVVAPRLRVYTelagdAITLPDFFKNRLNdknNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHF 174
Cdd:COG0591 81 ALGALLLALFFAPRLRRLG-----ALTIPEFLEKRFG---RGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 175 GLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAmKPTNLNLFKGLSFIGIISLFS 254
Cdd:COG0591 153 GILIGALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAALP-APGLLSLFPGLGFTGWLAFLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 255 ----WGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAyhIKLEDPETLFIVMSQVLFH 330
Cdd:COG0591 232 lflaIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPD--LPLADPDLALPLLILELLP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 331 PLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRgeeKAKTHQKEFVMVGRLSVLVVAIVAISIAWNPNDTILNL 410
Cdd:COG0591 310 PGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFI---KPKASDKQLLRVSRLAVLVVGLLALLLALLFPSSILDL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 411 VGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWIAWIKPLAHineIFGLYEIIPGFIVSVIVTYVVSKL 490
Cdd:COG0591 387 VLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGPLGP---FGWLYPILPGLLVSLLVFVVVSLL 463
|
490
....*....|..
gi 1105943496 491 TKKPGAFVETDL 502
Cdd:COG0591 464 TKPPSEEVLEEF 475
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
47-447 |
2.71e-90 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 281.92 E-value: 2.71e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 47 YMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGAYINYFVVAPRLRVYtelagDAITLPDFF 126
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNL-----GAYTMPDYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 127 KNRLNDKNnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIM 206
Cdd:pfam00474 76 RKRFGGKR-ILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLM 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 207 LIAMVMVPIVAMMNLNGWGTFHDVAA---------MKPTNLNLFKglSFIGIISLF-SWGLGYFGQPHIIVRFMSIKSHK 276
Cdd:pfam00474 155 LFGTIILMIIVFHEVGGYSSAVEKYMtadpngvdlYTPDGLHILR--DPLTGLSLWpGLVLGTTGLPHILQRCLAAKDAK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 277 MLPKARRLGISWMAVGLLGAVAVGLTGIAFV---PAYHI-KLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQ 352
Cdd:pfam00474 233 CIRCGVLILTPMFIIVMPGMISRGLFAIALAganPRACGtVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQ 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 353 LLVTSSSLTEDFYKLIRgeEKAKTHQKEFVMVGRLSVLVVAIVAISIAWNPND-TILNLVGNAWAGFGASFSPLVLFSLY 431
Cdd:pfam00474 313 LLSSSSAFTHDLYKNIR--RKASATEKELVGRSRIIVLVVISLAILLAVQPAQmGIAFLVQLAFAGLGSAFLPVILLAIF 390
|
410
....*....|....*.
gi 1105943496 432 WKGLTRAGAVSGMVSG 447
Cdd:pfam00474 391 WKRVNEQGALWGMIIG 406
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
19-488 |
3.47e-83 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 265.19 E-value: 3.47e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFYGYKQaTGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGA 98
Cdd:cd10322 3 LIIVVVYLALLLGIGLYASKK-VKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 99 YINYFVVAPRLRVYTelagdAITLPDFFKNRLNDKnnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLIL 178
Cdd:cd10322 82 LLLALFLAPRLRRLG-----KTTIPETILERYYSK--GLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVII 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 179 VAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLnGWGTFHDVAAMKPTNLNLFKGLSFIGIISLFS---- 254
Cdd:cd10322 155 AAVIVILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKV-GGGGFSALAAALPALLLALGPGGGLGWSTILSlill 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 255 WGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPayhiKLEDPETLFIVMSQVLFHPLVG 334
Cdd:cd10322 234 TGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFP----DLENPDLALPTLINSLLPPGLA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 335 GFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAkthQKEFVMVGRLSVLVVAIVAISIAWNPNDtILNLVGNA 414
Cdd:cd10322 310 GLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKAS---DKKLLRVSRIAVVVVGVLALLLALLPPS-ILLLLSLA 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1105943496 415 WAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWIAWIKPLahineIFGLYEIIPGFIVSVIVTYVVS 488
Cdd:cd10322 386 AGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLAS-----PLGIDPIIPALLVSLIVFVVVS 454
|
|
| PanF |
COG4145 |
Na+/panthothenate symporter [Coenzyme transport and metabolism]; |
14-494 |
3.56e-80 |
|
Na+/panthothenate symporter [Coenzyme transport and metabolism];
Pssm-ID: 443316 Cd Length: 484 Bit Score: 258.23 E-value: 3.56e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 14 ANWQTYIMIGVYFVILIVIGFYGYKQA--TGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWIT 91
Cdd:COG4145 2 MNLAILIPLLIYLLLVLGIGIYASRKRskGSFLEEYFLGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLGWVLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 92 IGLTLGAYINYFVVAPRLRVYTELAGdAITLPDFFKNRLNdkNNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLD 171
Cdd:COG4145 82 MIQVPTAFLTLGVLGKKFAILGRKYN-AVTLADWLRARYQ--SKALVLLAALLLLLFFIAFMVAQFVGGARLLETVTGIS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 172 YHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGW-GTFHDVAAMKPTNLNLFKGLSFIGII 250
Cdd:COG4145 159 YTTGLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLLLIGVISAGGGIeNIMSTLAAIDPNLVSPTGPDGFLPRP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 251 SLFS----WGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPayhiKLEDPETLFIVMSQ 326
Cdd:COG4145 239 FVISfwilVGFGVIGLPHTAVRCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGRAVLP----DLTVPDQVIPTLMV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 327 VLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRgEEKAKTHQKEFVMVGRLSVLVVAIVAISIAWNPNDT 406
Cdd:COG4145 315 KVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYI-NPKASENEKKLKRLSKLVTLVLGLIVFLLALNPPDL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 407 ILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVViIWIAWIKPLahineIFGLYEIIPGFIVSVIVTYV 486
Cdd:COG4145 394 IIWLNLFAFGGLEAAFFWPLVLGLYWKRANATGAIASMLVGVASY-FLLYYGNPK-----IFGFHAIVPSLLISLIAFLI 467
|
....*...
gi 1105943496 487 VSKLTKKP 494
Cdd:COG4145 468 GSLLGKPP 475
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
50-447 |
7.19e-75 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 242.21 E-value: 7.19e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 50 GGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSamwitIGLTLGAYINYFVVAPRLRVYTELAGDAITLPDFFKNR 129
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFA-----IGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 130 LNDKnnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIA 209
Cdd:TIGR00813 76 FGKR--ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 210 MVMVPIVAMMNLNGWGTFHDV---AAMKPTNLNLFKGLSFIGIISLFSWGLGYFGQPH----------IIVRFMSIKSHK 276
Cdd:TIGR00813 154 TFILPVFAFSEVGGLGTFVEKasqAAPTNPSPDDLYDFFRDPSTSDLPWGAGVFGLPHvalwywtnqvIVQRCLAAKSAK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 277 MLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAYH-----IKLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISS 351
Cdd:TIGR00813 234 HAKKGCLISGVLKLLPMFGAVLPGLIARALYTDIDpalagAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 352 QLLVTSSSLTEDFYKLIRgeEKAKTHQKEFVMVGRLSVLVVAIVAISIAWNPNDTILNLVGNAWAGFGASFSPLVLFSLY 431
Cdd:TIGR00813 314 QLNSASTVFTMDLYKKII--RPNASGEKKIVMRGRIAVLVAAVIAGFVAAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIF 391
|
410
....*....|....*.
gi 1105943496 432 WKGLTRAGAVSGMVSG 447
Cdd:TIGR00813 392 WKRMNAKGALAGMIAG 407
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
24-494 |
1.38e-70 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 232.87 E-value: 1.38e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 24 VYFVILIVIGFYGYKQATGN----LSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWI------TIG 93
Cdd:cd10327 7 IYLVILLGIGFYARRSKKRRsgdfLEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLamiqvpTGF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 94 LTLGAYINYF-VVAPRLrvytelagDAITLPDFFKNRLNdkNNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDY 172
Cdd:cd10327 87 LTLGVLGKKFaIIARKI--------NAVTIIDYLRARYN--SKALVVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 173 HFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWG-TFHDVAAMKPTNLNLFKG--LSFIGI 249
Cdd:cd10327 157 VTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGMEaIMATLAEIDPNLLTPFGPgfLSPPYI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 250 ISLF-SWGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPayhiKLEDPETLFIVMSQVL 328
Cdd:cd10327 237 LSFWvLVGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVLP----DLEVPDKVIPTLALKV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 329 FHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAKTHQKefvmVGRLSV---LVVAIVAISIAWNPND 405
Cdd:cd10327 313 LPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKEKKTSEKK----VKRISLiitIILGLLVFLLAINPPD 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 406 TILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWIAWIKPlahineIFGLYEIIPGFIVSVIVTY 485
Cdd:cd10327 389 LIVWLNLFAFGGLEAAFFWPLVLGLYWKRANATGALASMVVGLVSYILITYLKIK------ILGLHPIVPSLLLSLIAFI 462
|
....*....
gi 1105943496 486 VVSKLTKKP 494
Cdd:cd10327 463 IVSLATKKP 471
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
19-492 |
3.21e-52 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 184.71 E-value: 3.21e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFYGYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGA 98
Cdd:cd11477 3 WLVIALYFLLMLGIGLWFSKRASKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 99 YINYFVVAP---RLRVYTELAGDAItlpdFFKNRLNDKNNILKIISGLIIVVFFTLYThsGFVSGGKLFESAFGLDYHFG 175
Cdd:cd11477 83 LIGAFVFARrwrRLRVLTDGEFPEE----RYGGRYGAPLRQFYAVYFALLSNVDILAW--VFLAAIKVSAVFGPWDPWLT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 176 LILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHD-VAAMKPTNLNLFKGLSFIGIISLFS 254
Cdd:cd11477 157 ILILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFAqLPEGHLDLFGSGLGASGFYITFFFI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 255 WGLGYF------GQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAYHIKLEDPETLFIVMSQVL 328
Cdd:cd11477 237 LFFGWYplsysgGGWYLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLYPDLDDPEADFELAYPMMIKEY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 329 FHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRgeeKAKTHQKEFVMVGRLSVLVVAIVAISIAWNP--NDT 406
Cdd:cd11477 317 LPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFI---KPNASEKHLLKVGRLATVLFGLLSIVVALASdsIGG 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 407 ILNLVGNAWAGFGASFS-PLVLFSLYWKGlTRAGAVSGMVSGALVVIIWIAWIKPLAHineifgLYEIIPGFIVSVIVTY 485
Cdd:cd11477 394 AFWIVLALGAGLGGPLIlPWLWWRFNAWT-EIWAMIASIIVGLVVSVLLKVFGLPEDF------LFSFLVPVLLSLVVWL 466
|
....*..
gi 1105943496 486 VVSKLTK 492
Cdd:cd11477 467 AVTLLTP 473
|
|
| panF |
TIGR02119 |
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is ... |
16-494 |
3.51e-51 |
|
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This model describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (pfam00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A, Transport and binding proteins, Other]
Pssm-ID: 131174 Cd Length: 471 Bit Score: 181.08 E-value: 3.51e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 16 WQTYIMIGVYFVILIVIGFYGYKQATGN---LSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITI 92
Cdd:TIGR02119 1 WEVVIPLIIYLVTVFLIAIYASKRVQSTdsfLNEYFLGGRSMGGFVLAMTLVATYGSASSFIGGPGIAYNYGLGWVLLAM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 93 GLTLGAYINYFVVAPRLRVYTELAgDAITLPDFFKNRLNdkNNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDY 172
Cdd:TIGR02119 81 IQVPTGYFVLGVLGKKFAIISRKY-NAITINDVLKARYN--NKFLVWLSSISLLVFFFSAMVAQFIGGARLIESLTGLSY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 173 HFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGW-GTFHDVAAMKPTNLNLFKGLSFIGIIS 251
Cdd:TIGR02119 158 LTALFIFSSSVLIYTTFGGFRAVALTDAIQGIVMFTGTTILLIAVIKAGGGVeKIMEKLKDIDPNLITPFGGDGGLTKPF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 252 LFSW----GLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAyhikLEDPETLFIVMSQV 327
Cdd:TIGR02119 238 VASFwilvGIGVIGLPQTAVRCMSYKDSKAMHRAMIIGTIVVGIIMLGMHLAGVLGRAVIPD----LTVPDKVIPLLAIK 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 328 LFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAKTHQKEFVMvgrLSVLVVAIVAISIAWNPNDTI 407
Cdd:TIGR02119 314 VLPPILAGIFLAAPMAAIMSTVNSLLLQSSSTIIKDLYLNYIPKEAKESKIKKISM---CITLIIGLLVIIAAIKPPDLI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 408 LNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIwIAWIKPlahinEIFGLYEIIPGFIVSVIVTYVV 487
Cdd:TIGR02119 391 IWLNLFAFGGLEAAFIWPIVLGLYWKRANATGALASMIVGVGSYIT-LESFKP-----KIFGLHNIVPSLVFALIAFIIG 464
|
....*..
gi 1105943496 488 SKLTKKP 494
Cdd:TIGR02119 465 SLFGKKS 471
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
7-499 |
1.65e-49 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 178.04 E-value: 1.65e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 7 ALSQQVDANWQTYIMIGVYFVILIVIGfYGYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLS 86
Cdd:COG4147 3 ALLEQLGMNLLAIGIFLVFVTFTLYIT-IWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 87 AMWITIGLTLGAYINYFVVAPRLRVYtelagDAITLPDFFKNRLNDKNNILKIISGLIIVVFFtlYTHSGFVSGGKLFES 166
Cdd:COG4147 82 GLIYSIGWLVGYVLLLLLLAEYLRNF-----GKFTVPDFLGDRFYSRPARLVAAISTLVVSFF--YLIAQMVGAGVLISL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 167 AFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAmVMVPIVAMMNLNGW---GTFHDVAAMKPTNLNLFK- 242
Cdd:COG4147 155 LLGVDYEVAVVIVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFA-YTVPAVLVLAQFGFnplPLLAKAAEVHDLGAAYLEp 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 243 GLSFIGIISLFSWGL----GYFGQPHIIVRFMSIKSHKmlpKARR---LGISWMAVGLLGAVAVGLTGIAFVP------- 308
Cdd:COG4147 234 GGLVKSPLDFISLGLalmlGTAGLPHILMRFFTVPDAK---EARKsvgWALGFIGLFYLTAPALGFGARALVGplpewfd 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 309 AYHIKLEDPETLFIVM--SQVLFHP-LVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYK-LIRGeekaKTHQKEFVMV 384
Cdd:COG4147 311 TGLIGAADGGGNMAVLalAEIAGGGnWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYAnVIKG----KATEKEELRV 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 385 GRLSVLVVAIVAISIAWN-PNDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSG---ALVVIIWIAWIKP 460
Cdd:COG4147 387 ARIAAVVIGVVAILLGINaPPQNVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGlisALVLIVLSPFVWV 466
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1105943496 461 LAHINEIFGLyeIIPGFI---VSVIVTYVVSKLTKKPGAFVE 499
Cdd:COG4147 467 LGVDAALFPL--ENPGLVsmpLGFLVAIVVSLLTPEPPAEDQ 506
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
20-490 |
3.90e-45 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 164.99 E-value: 3.90e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 20 IMIGVYFVILIVIGFYGYKQaTGNLSEYMLGGRSIGPYITALsAGASD-MSGWMIMGLPGSVYSTGLSAMWITIGLTLGA 98
Cdd:cd11480 2 GLFFVFVTITLYITIWAARR-TRSTSDFYVAGRGVPPVQNGL-AIAGDyMSAASFLGIAGLIALSGYDGLAYAIGWTGGY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 99 YINYFVVAPRLRVYTelagdAITLPDFFKNRLNDKNniLKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLIL 178
Cdd:cd11480 80 VLLLLLVAEPLRNFG-----KYTVPDFLGARLGSRP--VRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 179 VAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMKPTNLNLFK--------GLSFIGII 250
Cdd:cd11480 153 VGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGNPLGAGPGLLGLAAAAASGageaylapGLLLTDPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 251 SLFSWGLGYF----GQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAYHIKLEDPETLFI---- 322
Cdd:cd11480 233 DVISLTLALMlgtaGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPIAGELDGggdm 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 323 ---VMSQVLFHP-LVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFY-KLIRgeeKAKTHQKEfVMVGRLSVLVVAIVAI 397
Cdd:cd11480 313 avlLLPEIAGLGdLLLALVAAGAFAAILATVAGLLLAAASALAHDLYaGVIR---PGASERRE-VRVARIAAVVVGVIAI 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 398 SIAWNPNDT-ILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWIAW---IKPLAHINEIFGLYEI 473
Cdd:cd11480 389 LLALLFPPQnVAFLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIVLspaVSGAPPGHDFAGFPLT 468
|
490 500
....*....|....*....|
gi 1105943496 474 IPGFI---VSVIVTYVVSKL 490
Cdd:cd11480 469 NPGLVsvpLGFLVAIVVSLL 488
|
|
| YidK |
COG4146 |
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ... |
15-453 |
5.67e-42 |
|
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];
Pssm-ID: 443317 [Multi-domain] Cd Length: 444 Bit Score: 155.69 E-value: 5.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 15 NWQTYIMIGVYFVILIVIGFYGYKQATGNLSE-YMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAM---WI 90
Cdd:COG4146 4 STLDYIVFLLYFLLVAGIGYWVSRKKKEKTSEdYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAayeWM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 91 -TIGLTLGAyinyFVVAPRLrvyteLAGDAITLPDFFKNRLNDKnnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFG 169
Cdd:COG4146 84 aAIALIILA----LFFLPFY-----LKSGIYTMPEFLEKRYDRR--TRTILSILFLVSYVFVNLPSVLYAGALALNTIFG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 170 LDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMK---PTNLNLFKGLS- 245
Cdd:COG4146 153 VPLWISVIGLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGDGSVLAGWSALLkvpPEKFNMIGPADd 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 246 --------FIG--IISLFSWGlgyFGQpHIIVRFMSIKShkmLPKARRlGISWMAVG-LLGAVAVGLTGIAFVPAYHIKL 314
Cdd:COG4146 233 pdlpwlgiFTGmpILNLFYWG---TNQ-YIVQRALGAKN---LKEAQK-GVLFAGFLkLLIPFIVVLPGIIAFVLFPDGL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 315 EDPETLFIVM-SQVLFHPLVGgFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAkthQKEFVMVGRLSVLVVA 393
Cdd:COG4146 305 DNPDQAYPTLvKNLLPVGLKG-LVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNAS---EKQLVKVGRIATVVLA 380
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1105943496 394 IVAISIAwnpndTILNLVGNAWA---GFGASFSP----LVLFSLYWKGLTRAGAVSGMVSGALVVII 453
Cdd:COG4146 381 VIAILIA-----PLIGNADGLFQyiqEVTGFFSPpilaVFLLGLFWKRVTAKAAKVALIAGIVLSIL 442
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
20-494 |
1.82e-40 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 151.91 E-value: 1.82e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 20 IMIGVYFVILIVIGFYGyKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSamWIT---IGLTL 96
Cdd:cd11474 2 IGVILYYLLILGIGLWA-SRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLG--GVAqdpFGYAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 97 GAYINYFVVAPRLRvytelAGDAITLPDFFKNRLNDKnniLKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGL 176
Cdd:cd11474 79 CLILGGLFFAKPMR-----RMGLLTLGDFFRQRYGRR---VEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 177 ILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMK----PTNLNLFKGLSFIGIISL 252
Cdd:cd11474 151 LISAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIASAAAAGKlrffPWLGTKSDWLIWIDAWLT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 253 FSWGlgyfGQPHIIV--RFMSIKSHKMlpkARRL----GISWMAVGLLgAVAVGLTGIAFVPAY--HIKLEDPETLFIVM 324
Cdd:cd11474 231 LGLG----SIPQQDVfqRVLSAKSEKT---AQRLsllaGVGYLLFAIP-PLLIGLAAASIDPSLtqYGLEEDAQLILPLL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 325 SQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRgeeKAKTHQKEFVMVGRLSVLVVAIVAISIAwNPN 404
Cdd:cd11474 303 LQYLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPF---RPKASDRELLWVMRISVVVFGAIATLMA-LTV 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 405 DTILNLVGNAWA-GFGASFSPLVlFSLYWKGLTRAGAVSGMVSGALVviiWIAWIKPLAHINEIFGLYeiIPGFIVSvIV 483
Cdd:cd11474 379 ESIYGLVELASDlVLVGLFVPLL-AGLYWKRANTYGALAAIIVGLVL---RLLGGELLLGLPADIPPQ--LQGFPFS-TL 451
|
490
....*....|.
gi 1105943496 484 TYVVSKLTKKP 494
Cdd:cd11474 452 AMVIGSLLPLA 462
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
19-494 |
6.13e-38 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 144.67 E-value: 6.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFYGYKQATgNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLG- 97
Cdd:cd11479 3 YGVIALYFAAMIAIGWWGMRRAK-TSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLVVAIGLGi 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 98 AYINYFVVAP--RLRVYTelagdaitLPDFFKNRLNDKNnilKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFG 175
Cdd:cd11479 82 LALSLLLAKRiaRLKVYT--------VSEVLELRYGPSA---RVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 176 LILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMV-PIVAMMNLNGWGTFhdVAAMKPTNLNLFKglsfIGIISLFS 254
Cdd:cd11479 151 ILVGGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLlLPLALSKAGGLSGL--QEKLPASYFDLTS----IGWDTIVT 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 255 WGLGYF-----GQpHIIVRFMSIKSHKMlpkARRLGISWMAVGLLGAVAVGLTGIAfVPAYHIKLEDPETLFIVMSQVLF 329
Cdd:cd11479 225 YFLLYFfgiliGQ-DIWQRVFTARSEKV---ARWGGVAAGLYCVLYGVAGALIGMA-AAVLLPDLANPQNAFATMAQEVL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 330 HPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAKthqKEFVMVGRLSVLVVAIVAISIAWNPNDTILN 409
Cdd:cd11479 300 PVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESE---RSEVRLSRLFTLLLGVVVIVIAVLVNDVVAA 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 410 LVGNAWAGFGASFSPLVLfSLYWKGLTRAGAVSGMVSGALVVIIWIAWIKPLAHineifglYEIIPGFIVSVIVTYVVSK 489
Cdd:cd11479 377 LTIAYAILVGGLLVPILG-GLFWKRATGAGALASMVAGSVVVLAGMAVDGLLAN-------TPIYYGLAVSLVAFVAVSL 448
|
....*
gi 1105943496 490 LTKKP 494
Cdd:cd11479 449 LTRPT 453
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
19-494 |
1.95e-33 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 133.08 E-value: 1.95e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFYGYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLS-------AMWIT 91
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWSSRKKRSTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAvgnyewnAAFVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 92 igLTLGayinyFVVAP---RLRVYtelagdaiTLPDFFKNRLNDK-NNILKIISgLIIVVF----FTLYthsgfvSGGKL 163
Cdd:cd10329 81 --LLLG-----WVFLPfyiRSGVS--------TMPEFLEKRFGGRsRVYLSVLS-LILYVFtkisVDLY------AGALV 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 164 FESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLN-GWGTFHDvAAMKPTNLNLFK 242
Cdd:cd10329 139 IKQLLGWDLYLSIIVLLVITAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGgGWSAYMA-AIPSGTAFHLFR 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 243 GLS---------FIG--IISLFSWGLgyfgQPHIIVRFMSIKShkmLPKARR--LGISW---MAVGLL---GAVAVGL-- 301
Cdd:cd10329 218 PPDdpdlpwpglLLGypILGIWYWCT----DQVIVQRVLAAKN---LKHARRgaLFAGYlklLPLFLMvlpGMIARALfp 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 302 TGIAFVPAYHIKLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEekakTHQKEF 381
Cdd:cd10329 291 DLVACVVPCGNGVGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRPE----ASEKEL 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 382 VMVGRLSVLVVaiVAISIAWNPndTILNLVGNAWAGFGASFSPLV-------LFSLYWKGLTRAGAVSGMVSG---ALVV 451
Cdd:cd10329 367 VRVGRIATLVV--VVISILWAP--IIQAQGGSLFNYIQSVLSYLAppiaavfLLGIFWKRTNEQGAFWGLIAGlvlGLVR 442
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1105943496 452 IIWIAW----IKPLAHINEIFGLYEIIPGFIVSVIVTYVVSKLTKKP 494
Cdd:cd10329 443 LILEFAygepDTRPAIIGGIHFLYFAFLLFVVSVIVTVIVSLLTPPP 489
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
16-488 |
9.45e-29 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 118.84 E-value: 9.45e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 16 WQTYIMIGVYFVILIVIGFYG---YKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSA-MWIT 91
Cdd:cd11476 1 YGVVIGLGALFALLMVFITRLlkrYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGpFWYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 92 IGLTLGAYInYFVVAPRLRvytELAGDAITLPDFFKNRLNDKNNILKIISGLIIVVFFTLythSGFVSGGKLFESAFGLD 171
Cdd:cd11476 81 SGATLQILL-FAPLAIRIK---RLAPNAHTLLEIVRARYGTAAHLVFLVFALFTNVIVLA---MLLLGGSAVVNALTGMP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 172 YHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLN--GWGTFHD-VAAMKPTNLNLFKGLSFig 248
Cdd:cd11476 154 IVAASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTSSDigSPSKVYDlLQEAAPDLPVEGNQGSY-- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 249 iISLFSWGLGYFGQPHII-------------VRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAYHIKLE 315
Cdd:cd11476 232 -LTFKSKAGLIFGIINIVgnfgtvfldqgywQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALALGLNPTFEEV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 316 DPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRgeeKAKTHQKEFVMVGRLSVLVVAIV 395
Cdd:cd11476 311 SAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYI---NPNATGKQLLRVSRIAVIGFGLF 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 396 A-----------ISIAWnpndtILNLVGNAWagfGASFSPlVLFSLYWKGLTRAGAVSGMVSG-ALVVIIWIAWIKPL-A 462
Cdd:cd11476 388 MgglavglnyigISLGW-----LLLFMGILI---GSAVFP-VALGLYWRRQTGTAAVVSPIAGlVAGLAVWLVTAKSYyG 458
|
490 500 510
....*....|....*....|....*....|..
gi 1105943496 463 HINEI------FGLYEIIPGFIVSVIVTYVVS 488
Cdd:cd11476 459 EVNVDttggnyPMLAGNLVALFSPAIVSVLLS 490
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
16-490 |
1.88e-27 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 114.95 E-value: 1.88e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 16 WQTYIMIGVYFVILIVIGFYGYKQATgNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLT 95
Cdd:cd11495 3 WLDYLVLVIYLLAMLGIGLYFSKKQK-STDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 96 LGAYINYFVVAPRLRVYtelagDAITLPDFFKNRLNdknNILKIISGLIIVVFftlytHSGFVsGGKLF------ESAFG 169
Cdd:cd11495 82 IAAPLAAYFFVPFFRRL-----NVTSAYEYLEKRFG---PWARVYGSLLFILF-----QLGRM-GIVLYlpalalSAVTG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 170 LDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLN-GWGTFHDVAA------MKPTNLNLFK 242
Cdd:cd11495 148 INPYIIIILMGVLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPgGFGEVFDIAIangkfsLGDFSFSLTE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 243 -GLSFIGIISLFSWGLGYFGQPHIIVRFMSIKSHKMLPKArrlgiSWMAVGLLGAVAV--GLTGIAFVPAYHIKLEDPET 319
Cdd:cd11495 228 sTIWVIFIGGIFNNLQSYTSDQDVVQRYLTTKSIKEAKKS-----LWTNALLALPVALlfFGIGTALYVFYQQHPELLPA 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 320 LF----IVMSQVLFHPLVG--GFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAKTHQKefvmVGRLSVLVVA 393
Cdd:cd11495 303 GIngdaVFPYFIVTQLPVGvaGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLSPDPSDKQYLK----VARLITLLVG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 394 IVAISIA----WNPNDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVviiwIAWIKPLAhiNEIFG 469
Cdd:cd11495 379 LLGTLVAlylaNAGVKSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSIIV----IFWISLLY--TPIHF 452
|
490 500
....*....|....*....|.
gi 1105943496 470 LYEIIPGFIVSVIVTYVVSKL 490
Cdd:cd11495 453 FLYSVIGTLVCFVVGYVVSLL 473
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
19-493 |
1.40e-26 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 112.77 E-value: 1.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFYgYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAM-WITIGLTLG 97
Cdd:cd11478 3 YLIVAVYFVFVLGIGFY-LKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATVhFYWIGAIPA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 98 AYINYFVVAP---RLRVYTelagdaitLPDFFKNRLNDKnniLKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHF 174
Cdd:cd11478 82 MVFLGIVMMPfyyGSKVRS--------VPEYLKLRFNKS---TRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 175 GLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHD-VAAMKPTNLNLFKGL--------- 244
Cdd:cd11478 151 SIILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEkIDANGPPGWNGLSWGpqgsqstnp 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 245 --SFIGIISL--FSWGLGYFGQPHIIV-RFMSIKShkmLPKARRLGISWMAVGLL---GAVAVGLTGIAFVPAY-HIKLE 315
Cdd:cd11478 231 mgVNLGLVFGlgFVLSFGYWTTNFLEVqRAMAAKD---LSAARRTPLIAAFPKMFipfLVILPGLIALVLVPELgASGGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 316 DPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAKTHqkeFVMVGRLSVLVVAIV 395
Cdd:cd11478 308 DYNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKH---YLKVGRIATVVGVLI 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 396 AISIAWNPND--TILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWIAWIKPLAHIN-EIFG--L 470
Cdd:cd11478 385 SIGTAYIASSfnNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELGLIVYhSDMApnF 464
|
490 500
....*....|....*....|...
gi 1105943496 471 YEIIPGFIVSVIVTYVVSKLTKK 493
Cdd:cd11478 465 YGAWWAFVVCFVVTVLVSLLTKP 487
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
19-488 |
7.56e-24 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 104.22 E-value: 7.56e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFYgYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGA 98
Cdd:cd11494 3 WIVLVGYLLGILVYGVY-KGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGLPLAM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 99 YINYFVVAP---RLRVYTelagdaitLPDFFKNRLNDKNNILkiISGLIIVVfftlythSGFVSGGKLFESA------FG 169
Cdd:cd11494 82 IFLCITFVPvfyKLKVYT--------AYEYLERRFGLKTRLL--TSILFLIS-------RGLATGVTIYAPAiilstiLG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 170 LDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMV--MVPIVAMMNLNGWGTFHDVAAMKPTN-----LNLFK 242
Cdd:cd11494 145 WSLWLTILLIGGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFiaFGLLLKLLPVGFVDALLVAGKSGRLNaldfsFDLSD 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 243 GLSF-IGIISLFSWGLGYFGQPHIIV-RFMSIKShkmlPKARRLGISWMAVG--------LLGAVAVG---LTGIAFVPA 309
Cdd:cd11494 225 TYTFwSGLIGGFFLYLSYFGTDQSQVqRYLTAKS----IKEARKSLLLNGFLkfpmqffiLLIGVLVFvfyQFNPFPVSF 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 310 YHIKLEDPETLFIVMSQVLFHPLVG--GFLLAAILAAIMSTISSQLLVTSSSLTEDFYK-LIRGEEKakthQKEFVMVGR 386
Cdd:cd11494 301 NPAEDETKDTNYIFLRFVLNYLPPGviGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRrFFKKDAS----DEHYLKVSR 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 387 LSVLVVAIVAISIAW--NPNDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGalVVIIWIAWIKPlahi 464
Cdd:cd11494 377 LLTVFWGLLAIVFALfaGLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILG--VIVVIVLWLFP---- 450
|
490 500
....*....|....*....|....
gi 1105943496 465 nEIFGLYEIIPGFIVSVIVTYVVS 488
Cdd:cd11494 451 -DVSWLWWNVIGCVVVIGVALLLS 473
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
19-407 |
1.33e-23 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 103.41 E-value: 1.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFY-GYKQAtgNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLG 97
Cdd:cd10326 2 WAVVVVYFLILLAISYYtSRRNA--DNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 98 AYINYFVVAPRLRvytelAGDAITLPDFFKNRLNDKnnilkiiSGLIIVVFFTLytHSGFVSGGKLFESA---------- 167
Cdd:cd10326 80 YLIIAFVLLPLYY-----RLNLTSIYEYLEDRFGVS-------SRKTGAVFFLL--SRILGAGIRLYLVAlvlqqflfds 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 168 FGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGW--GTFHDVAAMKPTNLNLF---- 241
Cdd:cd10326 146 LGIPFWLTVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLGfgEAISAAGESGYSRIFNFdddn 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 242 KGLSFI-GIISLFSWGLGYFGQPHIIV-RFMSIKSHKMLPKARRLG--ISWMAVGLLGAVAVGLtgIAFVPAYHIKL--E 315
Cdd:cd10326 226 SRRTFWkQFLGGIFITIAMTGLDQDMMqRNLSCKNLKDAQKNMLTFgvILVPVNLLFLLLGVLL--YTYAQKNGIALpaK 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 316 DPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAKTHQKeFVMVGRLSVLVVAIV 395
Cdd:cd10326 304 DSDQLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRKSEKKSERK-YVHIAFSLTFVLGIL 382
|
410
....*....|..
gi 1105943496 396 AISIAWNPNDTI 407
Cdd:cd10326 383 VFGSASNSGSLI 394
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
19-458 |
1.47e-23 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 103.72 E-value: 1.47e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFY----GYKQATgnLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGL 94
Cdd:cd11492 3 YVVFVAMLLISAAIGIYfgffGGKQKT--TEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQYWLIVIAY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 95 TLGAYINYFvvaprlrvytelagdaITLPDFFKNRLNDK--------NNILKIISGLIIVVFFTLYThsGFVsggkL--- 163
Cdd:cd11492 81 VLVGPITAY----------------IFLPVFYNLQLTSVyeylelrfNRRVRLLASFLFILQMLLYL--PIV----Iyap 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 164 ---FESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAA------MK 234
Cdd:cd11492 139 alaLSQVTGINLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVGGFSEVWEIAEeggrleFF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 235 PTNLNLFKGLSFIGII--SLFSWgLGYFG-QPHIIVRFMSIKShkmLPKARR-LGISWMAVGLLGAVAVgLTGIAFVPAY 310
Cdd:cd11492 219 NFDPDPTVRHTFWSLVigGTFTW-LSLYGvNQTQVQRYLSLPS---LKSAKKaLWLNIVGLILILSLCC-FTGLVIYAKY 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 311 H---------IKLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGeEKAKTHQKEF 381
Cdd:cd11492 294 HdcdpltaglIKKPDQLLPYFVMDVLGHLPGLPGLFVAGIFSAALSTLSSGLNSLAAVILEDFIKPFFK-KKLSERQATN 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 382 VMvgRLSVLVVAIVAISIAWnpndtILNLVGN----AWAGFGASFSPLV-LFSLywkGL-----TRAGAVSGMVSGaLVV 451
Cdd:cd11492 373 IM--KLLVVVFGLLCIGLAF-----LVEKLGGvlqlSLSIFGITGGPLLgIFTL---GMffpwaNSKGALVGLLVG-LIF 441
|
....*..
gi 1105943496 452 IIWIAWI 458
Cdd:cd11492 442 MLWIGIG 448
|
|
| actP |
PRK09395 |
cation/acetate symporter ActP; |
10-496 |
5.62e-23 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 102.36 E-value: 5.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 10 QQVDANWQTYIMIGVYFVILIVIGFYGYKQATGNLSEYMLGGRsigpyITALSAG---ASD-MSGWMIMGLPGSVYSTGL 85
Cdd:PRK09395 28 EKQPTNWQAIIMFLIFVVFTLGITYWAAKRTRSASDFYTAGGG-----ITGFQNGlaiAGDyMSAASFLGISALVFTSGY 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 86 SAMWITIGLTLGAYINYFVVAPRLRVYTELagdaiTLPDFFKNRLNDKN-NILKIISGLIIVVFftlYTHSGFVSGGKLF 164
Cdd:PRK09395 103 DGLIYSIGFLVGWPIILFLIAERLRNLGKY-----TFADVASYRLKQGPiRTLSACGSLVVVAL---YLIAQMVGAGKLI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 165 ESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMM--NLNGWGTFHDVAAMKPTNLNLFK 242
Cdd:PRK09395 175 QLLFGLNYHVAVVLVGVLMMVYVLFGGMLATTWVQIIKAVLLLSGATFMAFMVMKhvGFSFENLFSEAVAVHPKGLAIMG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 243 GLSFIG-IISLFSWGL----GYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVpayhikLEDP 317
Cdd:PRK09395 255 PGGLVKdPISALSLGLalmfGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAIVLV------GTNP 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 318 ETLFIV--------MSQVLFHPLVG-----GFLLAAILAAIMSTISSQLLVTSSSLTEDFY-KLIRgeeKAKTHQKEFVM 383
Cdd:PRK09395 329 EFKDAAgaliggnnMAAVHLANAVGgnlflGFISAVAFATILAVVAGLTLAGASAVSHDLYaNVIK---KGKATERDELR 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 384 VGRLSVLVVAIVAI--SIAWNpNDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWI-----A 456
Cdd:PRK09395 406 VSKITTLVLGVVAIilGILFE-KQNIAFMVGLAFAIAASANFPVLLLSMYWKGLTTRGAVIGGWLGLISAVVLMilsptV 484
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1105943496 457 WIKPLAHINEIFGL-YEIIPGFIVSVIVTYVVSKLTKKPGA 496
Cdd:PRK09395 485 WVDILGHEKAIFPYeYPALFSMPLAFVGIWFFSITDNSARA 525
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
15-499 |
7.87e-21 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 95.64 E-value: 7.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 15 NWQTYIMIGVYFVILIVIGFYGYKQaTGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGL 94
Cdd:PRK12488 31 NWTAIGMFMVFVLFTLGITRWAARR-TRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFMNGYDGLLYALGV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 95 TLGAYINYFVVAPRLRVYTELagdaiTLPDFFKNRLNDKNNILKIISGLIIVVFFTLYTHsgFVSGGKLFESAFGLDYHF 174
Cdd:PRK12488 110 LAGWPIILFLIAERLRNLGKY-----TFADVVSYRLAQGPVRLTAAFGTLTVVLMYLVAQ--MVGAGKLIELLFGISYLY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 175 GLILVAFIVIFYTFFGGYLAvsiTDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMKPTNLN------LFKGLSFIG 248
Cdd:PRK12488 183 AVVIVGALMVLYVTFGGMLA---TTWVQIIKAVLLLSGTSFMAFMVLKHFGFSTEAMFASAVAVHakgqaiLAPGGLLSN 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 249 IISLFSWGLGYF----GQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFV---PAYHI---KLEDPE 318
Cdd:PRK12488 260 PIDAISLGLGMMfgtaGLPHILMRFFTVSDAREARKSVLYATGFIGYFYLLIIVVGFGAIVMVgtePSYRDaggKIIGGG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 319 TLFIV-MSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFY-KLIRgeeKAKTHQKEFVMVGRLSVLVVAIVA 396
Cdd:PRK12488 340 NMVAVhLAQAVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYaCVIR---KGQASEAQEMRVSKIATLGIGLLA 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 397 ISIA-WNPNDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSG-----ALVVIIWIAWIKPLAHINEIF-- 468
Cdd:PRK12488 417 VVLGlMFESQNIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGlvsavVLVVLGPAVWVNVLHNATALFpy 496
|
490 500 510
....*....|....*....|....*....|....
gi 1105943496 469 ---GLYEIIPGFIVSvivtYVVSKLTKKPGAFVE 499
Cdd:PRK12488 497 snpALFSMSLAFLSA----WVFSVTDRSERAVAE 526
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
19-488 |
1.09e-19 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 91.89 E-value: 1.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIG-FYGYKQAtgNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLG 97
Cdd:cd11493 2 LAVIVLYLLGLPLLGlWLSGRQK--STADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 98 AYINYFVVAPRLRvytelAGDAITLPDFFKNRLNDKnnilkiISGLIIVVFftLYTHSgFVSGGKLFESA---------- 167
Cdd:cd11493 80 RIIVAFVLLPRYF-----RGEVVSAYELLGQRFGGG------MQKTASVTF--LVTRL-LADGVRLFAAAipvsmilgad 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 168 -FGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLN-GWGTFHDVAAmKPTNLNLFKGLS 245
Cdd:cd11493 146 gVALSYIASILIISVVTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPaDWLQIAAAAG-KFHLFDLSDLIL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 246 FI--------GIISLFSWGLGYFGQPHIIV-RFMSIKShkmLPKARRLGI-SWMAVGLLGAV--AVGLTGIAFVPAYHI- 312
Cdd:cd11493 225 GLtspytfwaAIIGGALLSMASHGTDQLMVqRLLACRN---LRDAQKALIgSGVVVFPQFALflLIGLLLYVYYGGASLa 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 313 KLEDPETLFIVMSQVLfHPL---VGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAKTHqkeFVMVGRLSV 389
Cdd:cd11493 302 ALGLGSPDEVFPYFIV-HELpagLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEK---LLRASRLLT 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 390 LVVAIVAISIAWNPNDTILNLVGNAWAGFGASFSPLV---LFSLYWKGLTRAGAVSGMVSGALVVIIWIAWIKPLAHINE 466
Cdd:cd11493 378 LVWAVVLVGIALLFQYTDQPVVELGLSIASFTYGGLLgvfLLGLLTRRASQRDAIAAFIVGFLVMLLLIFGVKFLGLLFA 457
|
490 500
....*....|....*....|...
gi 1105943496 467 I-FGLYEIIpGFIVSVIVTYVVS 488
Cdd:cd11493 458 LaFPWYVPI-GTLVTFLVGLLLS 479
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
18-505 |
2.62e-19 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 90.71 E-value: 2.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 18 TYIMIGVYFVILIVIGFYGYKQATGNLSE---YMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAM-W-ITI 92
Cdd:PRK10484 1 MLTILSFLGFTLLVAVISWWKTRKTDTSSsdgYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMaWeVTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 93 GLTLGAYINYFVvaPRLrvyteLAGDAITLPDFFKNRLnDKN-----NILKIISGLIIVVFFTLYthSGFVSGGKLFE-- 165
Cdd:PRK10484 81 AIALIILALIFL--PRY-----LKSGITTIPDFLEERY-DKTtrrivSILFLIGYVVSFLPIVLY--SGALALNSLFHvs 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 166 SAFGLDYHFGLILVAFIV----IFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNL---NGWGTFHDVAAMKPTNL 238
Cdd:PRK10484 151 ELLGISYGAAIWLLVWLIgiigAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALgdgSFMQGLEQLTTVHPEKL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 239 N-------------LFKGLSFigiISLFSWGLgyfgQPHIIVRFMSIKSHKMLPKarrlGISWMAVG-LLGAVAVGLTGI 304
Cdd:PRK10484 231 NsiggatdpvpfptLFTGLIL---VNLFYWCT----NQSIVQRALGAKNLAEGQK----GALLAAFFkLLGPLILVLPGI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 305 AfvpAYHI---KLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAkthQKEF 381
Cdd:PRK10484 300 I---AFHLygdGLPNADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNAS---EKQL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 382 VMVGRLSVLVVAIVAISIA---WNPNDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALVVIIWIAWI 458
Cdd:PRK10484 374 VKVGKKFGFVLAIISMIVApliANAPQGLYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGIILYIIINFVL 453
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1105943496 459 KPLAHINEIFGLYeiipgFIVSVIVTYVVSKLTKKPGAFVETDLNKV 505
Cdd:PRK10484 454 KFDIHFLYVLAIL-----FVINVVVMLIIGKIKPRETPFVLKDAFAV 495
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
25-400 |
4.73e-19 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 89.90 E-value: 4.73e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 25 YFVILIVIGFYGY-KQATGNLS---EYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGAYI 100
Cdd:cd10328 1 FLLFTALVALISWyKTRGDDLSssdGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSVMAWEVTAAIALII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 101 NYFVVAPRLrvyteLAGDAITLPDFFKNRLNDknNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGL---- 176
Cdd:cd10328 81 LALVFLPRY-----LKGGITTIPEFLEERYDE--TTRRIVSILFLLGYVVILLPIVLYSGALALNSLFDVSELLGIsyfq 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 177 ------ILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNG---WGTFHDVAAMKPTNLN-------- 239
Cdd:cd10328 154 alwllvWLIGIIGAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALGDgsfLAGLDTLLTAHPEKLNaiggadsp 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 240 -----LFKGLSFigiISLFSWGLGYFgqphIIVRFMSIKSHKMLPKarrlGISWMAVG-LLGAVAVGLTGIAFVPAYHIK 313
Cdd:cd10328 234 vpfstLFTGMLL---VNLFYWCTNQA----IIQRALAAKNLKEGQK----GVLLAGFFkLLVPLILVLPGIIAFHLYGDG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 314 LEDPETLF-IVMSQVLFHPLVgGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAkthQKEFVMVGRLSVLVV 392
Cdd:cd10328 303 LENADMAYpTLVADVLPKWLS-GFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNAT---DKQLVKVGKIFGIVL 378
|
....*...
gi 1105943496 393 AIVAISIA 400
Cdd:cd10328 379 ALISMIIA 386
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
20-494 |
4.94e-18 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 86.98 E-value: 4.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 20 IMIGVYFVILIVIGFYGYKQATG---NLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGL---SAMWITiG 93
Cdd:cd10325 1 VIFIVYVILIIGLGLWVSREKKGgekDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLaiaSYEWMA-A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 94 LTLGAYINYFvvaprLRVYteLAGDAITLPDFFKNRLNDKNNILKIISGLIIVVFFTLytHSGFVSGGKLFESAFGLDYH 173
Cdd:cd10325 80 ITLIIVAKFF-----LPIF--LKNGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFVNL--TSVLYLGALAIETITGIPLT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 174 FGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNG----WGTFHDVAAMKPTNLNL--------- 240
Cdd:cd10325 151 YSIIGLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGgegvFAGFTLLAAEAPEHFHMildksnped 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 241 ----FKGLSFI----GIISLFSWGlgyFGQpHIIVRFMSIKShkmLPKARRlGISWMA-VGLLGAVAVGLTGIAfvpAYH 311
Cdd:cd10325 231 aykdLPGIAVLlgglWVANLSYWG---FNQ-YIIQRALAAKS---LSEAQK-GIVFAAfLKLLIPFIVVIPGIA---AYV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 312 I----------KLEDPETLFIVMSQvLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRGEEKAkthQKEF 381
Cdd:cd10325 300 LasnlllpaatGIEKPDQAYPWLLR-NLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKAS---EKQL 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 382 VMVGRLSVLVVAIVAISIAWNpndtiLNLVGNAWA------GFgasFSPLVL----FSLYWKGLTRAGAVSGMVSGALVV 451
Cdd:cd10325 376 VNVGRLAAVIALIIAALIAPP-----LLGLDQAFQyiqeytGF---ISPGILaiflLGLFWKRATSAGALVAAILSIVLS 447
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1105943496 452 IIWIAWIKPLAHINEIfGLYeiipgFIVSVIVTYVVSKLTKKP 494
Cdd:cd10325 448 ALFKFLLPELPFLDRM-GYV-----FFICVVLIVLVSLLTPKG 484
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
20-450 |
7.25e-16 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 80.36 E-value: 7.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 20 IMIGVYFVILIVIGFYGYKQAT-GNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLS-------AMWIT 91
Cdd:cd11488 3 AVVVVYFVFVLAVGIWSSIRASrGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAvggfewnAAWVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 92 IGLTlgayinyFVVAPrlrVYteLAGDAITLPDFFKNRLNDKNnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLD 171
Cdd:cd11488 83 IALG-------WIFVP---VY--IAAGVVTMPEYLKKRFGGQR-IRIYMSVLSLILYIFTKISTDIFSGALFIQVSLGWN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 172 YHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLnGWGTFHDVAAMK----------------P 235
Cdd:cd11488 150 LYLSTVILLAVTALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKV-GWYPGLEQQYEKaipaltvpnttchlprS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 236 TNLNLFK----------GLSFiGIISLFSWglGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIA 305
Cdd:cd11488 229 DAFHIFRdpvtgdipwpGLIF-GLTVLATW--VWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 306 FVPAyHIKLEDPETLF------IVMSQVLFHPLV--------GGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRge 371
Cdd:cd11488 306 LFPD-EVGCVDPDECQkicgakVGCSNIAYPKLVvelmpvglRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIR-- 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 372 ekAKTHQKEFVMVGRlsVLVVAIVAISIAWNP------NDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMV 445
Cdd:cd11488 383 --RRASEQELMVVGR--VFILLLVVISILWIPiiqtanSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLM 458
|
....*
gi 1105943496 446 SGALV 450
Cdd:cd11488 459 VGLVV 463
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
21-492 |
7.17e-15 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 77.28 E-value: 7.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 21 MIGVYFVILIVIGFYG-YKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGlsamwITIGLTLGAY 99
Cdd:cd11486 5 VIVIYFVVVLAVGVWAmVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAG-----IAIGGFEWNA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 100 INYFVVAPRLRVYTELAGDAITLPDFFKNRLNDKNnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILV 179
Cdd:cd11486 80 LVVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQR-IQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 180 AFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDvAAMKPTNLNLFKGLSFIG----------- 248
Cdd:cd11486 159 LAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFME-KYMTAIPSVIGTGNSTSQekcytpradsf 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 249 ----------------IISLFSWGLGYFGQPHIIV-RFMSIK--SH-----------KMLPK---------ARRLGISWM 289
Cdd:cd11486 238 hifrdpitgdlpwpglLFGLSILTLWYWCTDQVIVqRCLSAKnmSHvkagcilcgylKLLPMfimvmpgmiSRILYTDEI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 290 AVGL------LGAVAVGLTGIAFvpayhikledPETLFIVMSQVLfhplvGGFLLAAILAAIMSTISSQLLVTSSSLTED 363
Cdd:cd11486 318 ACVVpdeckaVCGTEVGCTNIAY----------PKLVVELMPNGL-----RGLMLSVMLASLMSSLTSIFNSASTLFTMD 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 364 FYKLIRgeekAKTHQKEFVMVGRLSVLVvaIVAISIAWNP------NDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTR 437
Cdd:cd11486 383 IYTKVR----KKASEKELMIAGRLFMLV--LIGISIAWVPivqsaqSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNE 456
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1105943496 438 AGAVSGMVSGALVVIIWIawIKPLAH--------------INEIFGLYEIIPGFIVSVIVTYVVSKLTK 492
Cdd:cd11486 457 PGAFWGLCVGLLVGLARM--ITEFAYgtgscvnpsncptiICGVHYLYFAIILFGISCILILSISLMTK 523
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
20-450 |
2.90e-13 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 72.28 E-value: 2.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 20 IMIGVYFVILIVIGFYGYKQATGN-LSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGA 98
Cdd:cd11489 6 IVIGVYFALNVAVGIWSSCRVSRNtVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFEWNATYAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 99 YINYFVVAPrlrVYteLAGDAITLPDFFKNRLNDKNnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLIL 178
Cdd:cd11489 86 LALAWVFVP---VY--ISSGIVTMPEYLQRRFGGER-IRMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 179 VAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAM---------------KPTNLNLFK- 242
Cdd:cd11489 160 MLVVTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQIGGYSNLEEAYLQavpskiipnttchlpRADAMHLFRd 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 243 ---------GLSFiGIISLFSWglgYFGQPHIIV-RFMSIK--SH-----------KMLPkarrLGISWMAvGLLGAVAV 299
Cdd:cd11489 240 pvtgdlpwtGMTF-GLTIMATW---YWCTDQVIVqRSLSARslSHakggsilasylKMLP----MGLIIMP-GMISRALF 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 300 GLTGIAFVPAYHIKLEDPEtlfIVMSQVLFHPLV--------GGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRge 371
Cdd:cd11489 311 PDDVACVDPEECLRVCGAE---VGCSNIAYPKLVmelmpsglRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLR-- 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 372 ekAKTHQKEFVMVGRLsvLVVAIVAISIAWNP------NDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMV 445
Cdd:cd11489 386 --PGASERELLLVGRL--VTVILVGVSVVWIPilqssnSGQLYIYIQSVTSYLAPPVTAVFVLAVFWRRANEQGAFWGLM 461
|
....*
gi 1105943496 446 SGALV 450
Cdd:cd11489 462 AGLVV 466
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
20-494 |
1.17e-12 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 70.28 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 20 IMIGVYFVILIVIGFYG-YKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLS--AMWITIGLTL 96
Cdd:cd11491 3 AVVALYFILVMCIGIYAmWKSNRSTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAvgAFEFNALILL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 97 GAYInyfvvAPRLRVYteLAGDAITLPDFFKNRLNDKNnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGL 176
Cdd:cd11491 83 QLLG-----WVFIPVY--IRSGVYTLPEYLSKRFGGHR-IQVYLAALSLILYIFTKISVNLYSGALFIQEALGWNLYVSI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 177 ILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMKPTNLNLFKGLSFIG-------- 248
Cdd:cd11491 155 ILLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGFEGVKSRYMLASPNVTSILLTYNLSntnsccvh 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 249 ----------------------IISLFSWGLGYFGQPHIIV-RFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIA 305
Cdd:cd11491 235 pkkdafkllrdptdedvpwpgfILGQTPASIWYWCADQVIVqRVLAAKSLSHAQGATLMAGFIKLLPLFIIVIPGMISRI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 306 FVPAyHIKLEDPETLFIVM------SQVLFHPLV--------GGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRge 371
Cdd:cd11491 315 LFPD-DIACINPEHCMQVCgsragcSNIAYPRLVmkimpsglRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIR-- 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 372 ekAKTHQKEFVMVGRlsVLVVAIVAISIAWNPndTILNLVGNAW----AGFGASFSP----LVLFSLYWKGLTRAGAVSG 443
Cdd:cd11491 392 --KKASSRELMIVGR--IFVAVMVVISIAWIP--VIQEMQGGQLylyiQEVAAYLTPpvasLYLLAIFWKRTTEQGAFYG 465
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1105943496 444 M----VSGALVVIIWIAWIKPL--------AHINEIFGLYEIIPGFIVSVIVTYVVSKLTKKP 494
Cdd:cd11491 466 GmagfVLGAVRLILAFAYRAPEcgqpdnrpGIIKDIHYMYFATALFWITGLITVIVSLLTPPP 528
|
|
| SLC5sbd_SMVT |
cd11504 |
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ... |
19-456 |
4.71e-09 |
|
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271394 [Multi-domain] Cd Length: 527 Bit Score: 58.73 E-value: 4.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFY----GYKQATgnLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGL 94
Cdd:cd11504 6 YVVFSLLLVISAGIGLYyactGGKQKT--TREFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFGTQYWFLGCSY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 95 TLGAYINYFVVAP---RLRVYTELagdaitlpDFFKNRLNDKNNILKIISGLIIVVfftLYTHSGFVSGGKLFESAFGLD 171
Cdd:cd11504 84 FLGLLIPAHVFIPvfyRLELTSAY--------EYLELRFNKTVRICGTVTFIFQMV---IYMGVVLYAPALALNAVTGFN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 172 YHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAM-----------KPTNLNL 240
Cdd:cd11504 153 LWISVLAMGVVCTFYTALGGLKAVIWTDVFQTVVMFAGQLAVIIVGSIEAGGIARVWRVAAEsdridgfnlspDPTIRHT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 241 FKGLSFIGIISLFSWglgYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAY------HIKL 314
Cdd:cd11504 233 FWTLVVGGVFNMLAL---YGVNQAQVQRYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGLVMFARYHECdplkngIVAR 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 315 EDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDfykLIRGEEKAKTHQKEfVMVGRLSVLVVAI 394
Cdd:cd11504 310 SDQLVPYFVMDVLDGLPGLPGLFIACLFSGALSTISSAFNSLATVTMED---LIVPKFPDMTEERA-TLLSKGLAVGYGL 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1105943496 395 VAISIAWNPNdTILNLVGNAWAGFGASFSPLV-LFSL--YWKGLTRAGAVSGMVSGaLVVIIWIA 456
Cdd:cd11504 386 LCLLMAYLAS-TMGQVLQAANSIFGMIGGPLLgLFCLgmFFPCANSAGAVVGLLAG-LFMAFWIG 448
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
24-494 |
6.82e-09 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 58.38 E-value: 6.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 24 VYFVILIVIGFYG-YKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGAYINY 102
Cdd:cd11490 7 LYFLFVLAVGLWSmWKTKRSTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNGLFMVLVLA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 103 FVVAPrlrVYteLAGDAITLPDFFKNRLNDKNnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILVAFI 182
Cdd:cd11490 87 WLFLP---IY--IASRVTTMPEYLKKRFGGKR-IQIFLAVLYLFIYIFTKISVDMYAGAVFIQQALQWDLYLAVVGLLGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 183 VIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGT-----FHDVAAMKPTN----------LNLFK----- 242
Cdd:cd11490 161 TALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVGGFEAllekyFQAIPSIRSPNstcgipredaFHIFRdpvts 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 243 GLSFIGIISLFSW-GLGYFGQPHIIV-RFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAyHIKLEDPETL 320
Cdd:cd11490 241 DLPWPGVLLGMSIpSLWYWCTDQVIVqRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPD-QVACADPEVC 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 321 FIV------MSQVLFHPLV--------GGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLIRgeekAKTHQKEFVMVGR 386
Cdd:cd11490 320 KEIcgnpsgCSDIAYPKLVmellptglRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRHIR----PRASEWELMIVGR 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 387 LSVLVvaIVAISIAWNP------NDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAGAVSGMVSGALV----VIIWIA 456
Cdd:cd11490 396 VFVLV--LVVVSILWIPlvqasqGGQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAVgltrMVLDFI 473
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 1105943496 457 WIKPLAH--------INEIFGLYEIIPGFIVSVIVTYVVSKLTKKP 494
Cdd:cd11490 474 YVTPQCDqpdtrpdiVKYVHYLYFSMILTILTLVVVVCVSLATEPP 519
|
|
| SLC5sbd_SGLT2 |
cd11487 |
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
21-450 |
7.97e-08 |
|
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 54.93 E-value: 7.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 21 MIGVYFVILIVIGFYGYKQAT-GNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAM---W--ITIGL 94
Cdd:cd11487 5 VIAAYFLLVIGVGLWSMCRTNrGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIAVAgfeWnaLFVVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 95 TLGayinyFVVAPrlrVYteLAGDAITLPDFFKNRLNDKNnILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHF 174
Cdd:cd11487 85 LLG-----WLFVP---VY--LTAGVITMPQYLKKRFGGQR-IRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 175 GLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHD-----------------------VA 231
Cdd:cd11487 154 SVIALLGITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVGGYSALFEkylkavpsltvsedpavgnisssCY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 232 AMKPTNLNLFKGLS---------FIGIISLFSWglgYFGQPHIIVR-------FMSIKSHKMLPKARRLGISWMAV--GL 293
Cdd:cd11487 234 RPRPDSYHLLRDPVtgdlpwpalILGLTIVSSW---YWCSDQVIVQrclaarsLTHVKAGCILCGYLKLLPMFLMVmpGM 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 294 LGAVAVGLTGIAFVPAYHIKLEDPEtlfIVMSQVLFHPLV--------GGFLLAAILAAIMSTISSQLLVTSSSLTEDFY 365
Cdd:cd11487 311 ISRVLYPDEVACVEPSVCLRVCGTE---VGCSNIAYPKLVvklmpnglRGLMLAVMLAALMSSLASIFNSSSTLFTMDIW 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 366 KLIRgeekAKTHQKEFVMVGRlsVLVVAIVAISIAWNP------NDTILNLVGNAWAGFGASFSPLVLFSLYWKGLTRAG 439
Cdd:cd11487 388 TRLR----PQAGDKELLLVGR--VWVVCIVAVSVAWIPvvqaaqGGQLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPG 461
|
490
....*....|.
gi 1105943496 440 AVSGMVSGALV 450
Cdd:cd11487 462 AFWGLIGGLLM 472
|
|
| SLC5sbd_SMCT |
cd11505 |
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ... |
19-366 |
1.18e-07 |
|
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271395 Cd Length: 538 Bit Score: 54.12 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIGFY----GYKQATGNlsEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGlsAMWITIgl 94
Cdd:cd11505 9 YVVFAAMLFISAGIGIYyafaGGGQATSK--DFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYRFG--ASFLIF-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 95 tlgaYINYFVVAprlrvyteLAGDAITLPDFFKNRLNDK--------NNILKIISGLIIVVFFTLYTHSGFVSGGKLFES 166
Cdd:cd11505 83 ----AFAYLFVV--------LISSEVFLPVFYRLGITSTyeylelrfNKPVRLAGTVLFIVQTILYTGIVIYAPALALNQ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 167 AFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDvAAMKPTNLNLF----- 241
Cdd:cd11505 151 VTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAVVHQGGIHNILN-DSYNGSRLNFWdfdpn 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 242 --KGLSFIGII--SLFSWGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVavgLTGIAFVPAYH------ 311
Cdd:cd11505 230 plRRHTFWTITvgGTFTWTGIYGVNQSQVQRYISCKTRFQAKLSLYFNLLGLWAILVCAV---FSGLAMYSHYKdcdpwt 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1105943496 312 -IKLEDPETL--FIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYK 366
Cdd:cd11505 307 aKIVSAPDQLmpYLVLDILADYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIK 364
|
|
| SLC5sbd_SMCT1 |
cd11519 |
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ... |
21-366 |
4.23e-07 |
|
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271402 Cd Length: 542 Bit Score: 52.54 E-value: 4.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 21 MIGVYFVILIVIGFYGYKQATGnlSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGlsAMWITIGLTLgayi 100
Cdd:cd11519 15 MLLISAGIGIYYAFAGGGQQTS--KDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFG--AIFSIFAFTY---- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 101 nYFVVAPRLRVYtelagdaitLPDFFKNRLNDK--------NNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDY 172
Cdd:cd11519 87 -AIVVVISAEVF---------LPVFYRLGITSTyeylelrfNKCVRLIGTSLFIVQTALYTGIVIYAPALALNQVTGFDL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 173 HFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDvAAMKPTNLNLF-------KGLS 245
Cdd:cd11519 157 WGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFVSVIIRAVVLQGGIGTILN-DSYYGGRLNFWdfdpnplQRHT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 246 FIGII--SLFSWGLGYFGQPHIIVRFMSIKShkMLPKARRLGISWMAVGLLGAVAVgLTGIAFVPAYH-------IKLED 316
Cdd:cd11519 236 FWTIVigGTFTWTSIYGVNQSQVQRYISCKT--RFQAKMSLYVNLVGLWAILSCAV-LSGLAMYSIYKdcdpwtaKDVSA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1105943496 317 PETL--FIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYK 366
Cdd:cd11519 313 PDQLmpYLVLDILADYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIK 364
|
|
| SLC5sbd_SMCT2 |
cd11520 |
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ... |
19-366 |
2.73e-06 |
|
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212089 [Multi-domain] Cd Length: 529 Bit Score: 49.85 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 19 YIMIGVYFVILIVIG-FYGYKQATGNLS-EYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTl 96
Cdd:cd11520 9 YVVFAGLFLVSSGIGvFFAIKERKKATSkEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFGASFVLFFIAYT- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 97 gayinyFVVaprlrvyteLAGDAITLPDFFKNRLNDK--------NNILKIISGLIIVVFFTLYTHSGFVSGGKLFESAF 168
Cdd:cd11520 88 ------FVI---------IFTSELFLPVFYRSGITSTyeylelrfNKPVRYAATLIYIVQTILYTGVVVYAPALALNQVT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 169 GLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGwgtFHDV--AAMKPTNLNLF----- 241
Cdd:cd11520 153 GFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSIHNGG---FTNVweTAYNGSRLNIFdfdvd 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 242 --KGLSF--IGIISLFSWgLGYFG-QPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAfvpayHIKLED 316
Cdd:cd11520 230 plRRHTFwtITVGGTFTW-LGIYGvNQSTIQRCISCKTEKHAKLALYLNLLGLWIILVCAVFSGLIMYS-----HYKDCD 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1105943496 317 PETL-----------FIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYK 366
Cdd:cd11520 304 PWTSgfisapdqlmpYFVMEIFSTMPGLPGLFVACAFSGTLSTVAASINALATVTFEDFVK 364
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
23-223 |
3.60e-06 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 49.46 E-value: 3.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 23 GVYFVILIV---IG-FYGYKQATGNLSE-YMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLG 97
Cdd:cd11503 4 GVFAAMLLVstgIGlFVGLARGGQRSADdFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1105943496 98 AYINYFVVAPrlrVYTELAgdAITLPDFFKNRLNDKnniLKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLI 177
Cdd:cd11503 84 SLMTAVLFMP---VFYRLG--ITSTYQYLEMRFSRA---VRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLF 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1105943496 178 LVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNG 223
Cdd:cd11503 156 STGIICTFYTTVGGMKAVIWTDVFQVVVMLSGFWAVLIRGVILVGG 201
|
|
| |
