NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2321214948|gb|UYP50631|]
View 

NADH dehydrogenase subunit 6 (mitochondrion) [Microtus montanus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 8.10e-78

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 229.30  E-value: 8.10e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948   1 MTELIYFLSLVIAVGCLGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  81 AWVSSWLAIGILFMSIFMEMAMLYVSKYYEKMELVLEFNSMGGWVIYDGDGLGLMGEGGAGVAALYSCSAWLMVVSGWTL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|....
gi 2321214948 161 FMGVFIIIEITRGN 174
Cdd:MTH00109  162 FIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 8.10e-78

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 229.30  E-value: 8.10e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948   1 MTELIYFLSLVIAVGCLGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  81 AWVSSWLAIGILFMSIFMEMAMLYVSKYYEKMELVLEFNSMGGWVIYDGDGLGLMGEGGAGVAALYSCSAWLMVVSGWTL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|....
gi 2321214948 161 FMGVFIIIEITRGN 174
Cdd:MTH00109  162 FIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 2.13e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 55.59  E-value: 2.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  17 LGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPEAWVSSWLAIGILFMSI 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2321214948  97 FMEMAMLYvskyyekmelVLEFNSMGGWVIYDGDGLGLMGEGGagvAALYSCSAWLMVVSGWTLFMGVFIIIEI 170
Cdd:pfam00499  81 LLLALLLL----------VLLSASLTPAAAAAAPDVGNIEAIG---ELLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 8.10e-78

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 229.30  E-value: 8.10e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948   1 MTELIYFLSLVIAVGCLGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  81 AWVSSWLAIGILFMSIFMEMAMLYVSKYYEKMELVLEFNSMGGWVIYDGDGLGLMGEGGAGVAALYSCSAWLMVVSGWTL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|....
gi 2321214948 161 FMGVFIIIEITRGN 174
Cdd:MTH00109  162 FIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 1.69e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 101.37  E-value: 1.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948   1 MTELIYFLSLVIAVGCLGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  81 AWVS-SWLAIGILFMSIFMEMAMLYVSKYYEkmelvlefnsmGGWVIYD--GDGLGLMGEGGaGVAALYSCSAWLMVVSG 157
Cdd:MTH00138   81 SWGSwSVLGYVVGYLVGVVLAAGLFWGGWYE-----------GSWVVVDelKEFSVLRGDVG-GVALMYSSGGGMLVICA 148

                         170
                  ....*....|....*.
gi 2321214948 158 WTLFMGVFIIIEITRG 173
Cdd:MTH00138  149 WVLLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 3.86e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 100.31  E-value: 3.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948   1 MTELIYFLSLVIAVGCLGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  81 AWvSSWLAIGILFMSIFMeMAMLYVskyyekmeLVLEFNSMGGWVIYDGDGLGLMGEGGAGVAALYSCSAWLMVVSGWTL 160
Cdd:MTH00065   81 AW-GSWSVLVYVLFYLLL-LIVGYI--------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|...
gi 2321214948 161 FMGVFIIIEITRG 173
Cdd:MTH00065  151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 1.30e-21

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 85.96  E-value: 1.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948   1 MTELIYFLSLVIAVGCLGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  81 AWVSSWLAIGILFMSIFMEMAMLYVSKYYEKMelvlefnsMGGWVIYDGDGLGLMGEGGAGVAALYSCSAWLMVVSGWTL 160
Cdd:MTH00115   81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGME--------GVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|...
gi 2321214948 161 FMGVFIIIEITRG 173
Cdd:MTH00115  153 LLTLFVVLELVRG 165
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 5-174 6.87e-13

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 63.00  E-value: 6.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948   5 IYFLSLVIAVGCLGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPEawVS 84
Cdd:MTH00045    3 FYLFLILMLFGSTLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS--VS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  85 SWLAIGILFMSIFMEMAMLyvskyyekmelvleFNSMGGWVIYDGDGLGLMGEGGAGVaaLYSCSAWLMVVSGWTLFMGV 164
Cdd:MTH00045   81 NLGEVLVLSLLLSLWVFIS--------------FDNFLELSNNNWSLVSLSDLVGSSE--LYNSGGLYLLLGGFILLVAL 144

                         170
                  ....*....|
gi 2321214948 165 FIIIEITRGN 174
Cdd:MTH00045  145 VVALVISFGH 154
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 2.01e-11

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 59.23  E-value: 2.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948   1 MTELIYFLSLVIAVGCLGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  81 AWVSswlaigilfmsifmEMAMLYVSKYYEKMELVLEFNSMGGWVIYDGDGLGLMGEGGAGVAALYSCSAWLMVVSGWTL 160
Cdd:MTH00214   81 SWGG--------------WSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|...
gi 2321214948 161 FMGVFIIIEITRG 173
Cdd:MTH00214  147 FLVLFVVLELVRG 159
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 2.13e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 55.59  E-value: 2.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321214948  17 LGTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMSAEDYPEAWVSSWLAIGILFMSI 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2321214948  97 FMEMAMLYvskyyekmelVLEFNSMGGWVIYDGDGLGLMGEGGagvAALYSCSAWLMVVSGWTLFMGVFIIIEI 170
Cdd:pfam00499  81 LLLALLLL----------VLLSASLTPAAAAAAPDVGNIEAIG---ELLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 4-74 1.70e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 39.99  E-value: 1.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2321214948   4 LIYFLSLVIAVGCLgTSLKPSPIYGGLCLIVSGCSGCLAVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMS 74
Cdd:MTH00212    3 LSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH