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Conserved domains on  [gi|446105862|ref|WP_000183717|]
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MULTISPECIES: hypothetical protein [Staphylococcus]

Protein Classification

acetyl-CoA carboxylase biotin carboxylase subunit family protein( domain architecture ID 1903543)

acetyl-CoA carboxylase biotin carboxylase subunit family protein similar to Bacillus subtilis alanine--anticapsin ligase that is part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AccC super family cl43145
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 157-305 2.81e-07

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


The actual alignment was detected with superfamily member COG0439:

Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 51.41  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446105862 157 EQFENEIKNWEFPLVIKPGDDlptAGGYGVMICYHDADLQKAITRIK---EATAETNSLIIEQKIE--EkanYCVqfays 231
Cdd:COG0439   79 EEALAFAEEIGYPVVVKPADG---AGSRGVRVVRDEEELEAALAEARaeaKAGSPNGEVLVEEFLEgrE---YSV----- 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446105862 232 ESLGIQylGAA--TQLTDK-----YGFYNGNENTTNVPEHVIEAGRQIMENGVNQ-GF-FGVAGFDLLVDEDDNVYAIDL 302
Cdd:COG0439  148 EGLVRD--GEVvvCSITRKhqkppYFVELGHEAPSPLPEELRAEIGELVARALRAlGYrRGAFHTEFLLTPDGEPYLIEI 225


                 ...
gi 446105862 303 NFR 305
Cdd:COG0439  226 NAR 228
OTU super family cl45892
OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved ...
 122-176 2.93e-03

OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation.


The actual alignment was detected with superfamily member cd22799:

Pssm-ID: 459237  Cd Length: 266  Bit Score: 38.96  E-value: 2.93e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446105862 122 YYALDKTLFVALNNKARIPEW-TNGKF--LPKrkvvKIEQFENEIKNWEFPLVIKPGD 176
Cdd:cd22799   49 YCALRATLFQALSQAVGLPPWlQDPELmlLPE----KLISKYNWIKQWKLGLKFDGKN 102
 
Name Accession Description Interval E-value
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 157-305 2.81e-07

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 51.41  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446105862 157 EQFENEIKNWEFPLVIKPGDDlptAGGYGVMICYHDADLQKAITRIK---EATAETNSLIIEQKIE--EkanYCVqfays 231
Cdd:COG0439   79 EEALAFAEEIGYPVVVKPADG---AGSRGVRVVRDEEELEAALAEARaeaKAGSPNGEVLVEEFLEgrE---YSV----- 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446105862 232 ESLGIQylGAA--TQLTDK-----YGFYNGNENTTNVPEHVIEAGRQIMENGVNQ-GF-FGVAGFDLLVDEDDNVYAIDL 302
Cdd:COG0439  148 EGLVRD--GEVvvCSITRKhqkppYFVELGHEAPSPLPEELRAEIGELVARALRAlGYrRGAFHTEFLLTPDGEPYLIEI 225


                 ...
gi 446105862 303 NFR 305
Cdd:COG0439  226 NAR 228
OTU_OTUL cd22799
OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also ...
 122-176 2.93e-03

OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also called FAM105B, deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, or ubiquitin thioesterase Gumby, is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. It acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. Otulin belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in some cases an aspartate, as the catalytic dyad (or triad).


Pssm-ID: 438620  Cd Length: 266  Bit Score: 38.96  E-value: 2.93e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446105862 122 YYALDKTLFVALNNKARIPEW-TNGKF--LPKrkvvKIEQFENEIKNWEFPLVIKPGD 176
Cdd:cd22799   49 YCALRATLFQALSQAVGLPPWlQDPELmlLPE----KLISKYNWIKQWKLGLKFDGKN 102
PRK07206 PRK07206
hypothetical protein; Provisional
 160-228 5.59e-03

hypothetical protein; Provisional


Pssm-ID: 180883 [Multi-domain]  Cd Length: 416  Bit Score: 38.47  E-value: 5.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446105862 160 ENEIKNW-------EFPLVIKPgddLPTAGGYGVMICYHDADLQKAITRIKEATAETNSLIIEQKIEEKAN---YCVQF 228
Cdd:PRK07206 132 WEEAEAWlrengliDRPVVIKP---LESAGSDGVFICPAKGDWKHAFNAILGKANKLGLVNETVLVQEYLIgteYVVNF 207
 
Name Accession Description Interval E-value
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 157-305 2.81e-07

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 51.41  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446105862 157 EQFENEIKNWEFPLVIKPGDDlptAGGYGVMICYHDADLQKAITRIK---EATAETNSLIIEQKIE--EkanYCVqfays 231
Cdd:COG0439   79 EEALAFAEEIGYPVVVKPADG---AGSRGVRVVRDEEELEAALAEARaeaKAGSPNGEVLVEEFLEgrE---YSV----- 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446105862 232 ESLGIQylGAA--TQLTDK-----YGFYNGNENTTNVPEHVIEAGRQIMENGVNQ-GF-FGVAGFDLLVDEDDNVYAIDL 302
Cdd:COG0439  148 EGLVRD--GEVvvCSITRKhqkppYFVELGHEAPSPLPEELRAEIGELVARALRAlGYrRGAFHTEFLLTPDGEPYLIEI 225


                 ...
gi 446105862 303 NFR 305
Cdd:COG0439  226 NAR 228
OTU_OTUL cd22799
OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also ...
 122-176 2.93e-03

OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins; Otulin, also called FAM105B, deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, or ubiquitin thioesterase Gumby, is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. It acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. Otulin belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in some cases an aspartate, as the catalytic dyad (or triad).


Pssm-ID: 438620  Cd Length: 266  Bit Score: 38.96  E-value: 2.93e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446105862 122 YYALDKTLFVALNNKARIPEW-TNGKF--LPKrkvvKIEQFENEIKNWEFPLVIKPGD 176
Cdd:cd22799   49 YCALRATLFQALSQAVGLPPWlQDPELmlLPE----KLISKYNWIKQWKLGLKFDGKN 102
PRK07206 PRK07206
hypothetical protein; Provisional
 160-228 5.59e-03

hypothetical protein; Provisional


Pssm-ID: 180883 [Multi-domain]  Cd Length: 416  Bit Score: 38.47  E-value: 5.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446105862 160 ENEIKNW-------EFPLVIKPgddLPTAGGYGVMICYHDADLQKAITRIKEATAETNSLIIEQKIEEKAN---YCVQF 228
Cdd:PRK07206 132 WEEAEAWlrengliDRPVVIKP---LESAGSDGVFICPAKGDWKHAFNAILGKANKLGLVNETVLVQEYLIgteYVVNF 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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