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Conserved domains on  [gi|446397616|ref|WP_000475471|]
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MULTISPECIES: bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase [Vibrio]

Protein Classification

bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase( domain architecture ID 10456982)

bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase containing an N-terminal domain that may catalyze the transfer of an acetyl group from acetyl-CoA to a substrate and a C-terminal thioesterase domain, similar to Escherichia coli putative acetyltransferase YiiD

CATH:  3.10.129.10
EC:  2.3.1.-|3.1.2.-
Gene Ontology:  GO:0008080
PubMed:  10940244|9175471|15307895
SCOP:  3000149|3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YiiD_C pfam09500
Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed ...
 157-297 1.33e-75

Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed uncharacterized domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain pfam00583.


:

Pssm-ID: 430649  Cd Length: 144  Bit Score: 227.91  E-value: 1.33e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  157 CTELQDRWGKHIPISDKMGIKIQQYTGYQFQCCAQLNPNLNPHNTLFAGSAFTLATLTGWGMAWLLMRERDLQGDIVLVD 236
Cdd:pfam09500   1 CQELQETWHDHIPLSRAMGIKVTQYDGQEFILSAPLAPNINHHGTMFAGSIYTLATLTGWGLLWLLLKEAGLEGDIVLAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446397616  237 SHIRYRHPVVQNPVASTSL---DGISGDLDRLESGRKARIVVRVIISSGEVEAIEFIGTYMLIP 297
Cdd:pfam09500  81 GNIRYLKPVTGDPTARVSLptpEAWSGFLSRLARGGKARITLEVEIYSGGELAAEFTGRYVVLK 144
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
10-145 4.98e-37

Predicted N-acyltransferase, GNAT family [General function prediction only];


:

Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 128.76  E-value: 4.98e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  10 DNQLNKYFHFRWQMLREPWRMPIGSERDEYDSMSHHRMIVDSrGYPMAIGRLYITPDCEGQIRYMAVKANRRSKGMGSLI 89
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDD-GELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446397616  90 LVALESLARQEGAKRLVCNAREDAIPFYAKNGFERRGELTDERGpVRHQQMVKTLD 145
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAG-IPHIDMRKPLS 134
 
Name Accession Description Interval E-value
YiiD_C pfam09500
Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed ...
 157-297 1.33e-75

Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed uncharacterized domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain pfam00583.


Pssm-ID: 430649  Cd Length: 144  Bit Score: 227.91  E-value: 1.33e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  157 CTELQDRWGKHIPISDKMGIKIQQYTGYQFQCCAQLNPNLNPHNTLFAGSAFTLATLTGWGMAWLLMRERDLQGDIVLVD 236
Cdd:pfam09500   1 CQELQETWHDHIPLSRAMGIKVTQYDGQEFILSAPLAPNINHHGTMFAGSIYTLATLTGWGLLWLLLKEAGLEGDIVLAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446397616  237 SHIRYRHPVVQNPVASTSL---DGISGDLDRLESGRKARIVVRVIISSGEVEAIEFIGTYMLIP 297
Cdd:pfam09500  81 GNIRYLKPVTGDPTARVSLptpEAWSGFLSRLARGGKARITLEVEIYSGGELAAEFTGRYVVLK 144
yiiD_Cterm TIGR02447
thioesterase domain, putative; This family consists of a broadly distributed uncharacterized ...
 164-297 2.76e-51

thioesterase domain, putative; This family consists of a broadly distributed uncharacterized domain found often as a standalone protein. The member from Shewanella oneidensis, PDB|1T82_A (Forouhar, et al., unpublished) is described from crystallography work as a putative thioesterase. About half of the members of this family are fused to an Acetyltransf_1 domain (pfam00583). The function of this protein is unknown.


Pssm-ID: 131500  Cd Length: 138  Bit Score: 165.60  E-value: 2.76e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  164 WGKHIPISDKMGIKIQQYTGYQFQCCAQLNPNLNPHNTLFAGSAFTLATLTGWGMAWLLMRERDLQGDIVLVDSHIRYRH 243
Cdd:TIGR02447   2 LHSAIPLSEAMGIAVSSYTGGELRLSAPLAANINHHGTMFGGSLYTLATLSGWGLLWLRLQELGIDGDIVIADSHIRYLA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446397616  244 PVVQNPVAST---SLDGISGDLDRLESGRKARIVVRVIISSGEVEAIEFIGTYMLIP 297
Cdd:TIGR02447  82 PVTGDPVANCeapDLESWEAFLATLQRGGKARVKLEAQISSDGKLAATFSGEYVALP 138
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
10-145 4.98e-37

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 128.76  E-value: 4.98e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  10 DNQLNKYFHFRWQMLREPWRMPIGSERDEYDSMSHHRMIVDSrGYPMAIGRLYITPDCEGQIRYMAVKANRRSKGMGSLI 89
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDD-GELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446397616  90 LVALESLARQEGAKRLVCNAREDAIPFYAKNGFERRGELTDERGpVRHQQMVKTLD 145
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAG-IPHIDMRKPLS 134
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 13-122 4.56e-09

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 53.29  E-value: 4.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616   13 LNKYFHFRWQMLREPWRMPIGSERDEYDSMSHHRMIVDSR-GYPMAIGRLYITPD--CEGQIRYMAVKANRRSKGMGSLI 89
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEdGELVGFASLSIIDDepPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446397616   90 LVALESLARQEGAKRLVCNARED---AIPFYAKNGF 122
Cdd:pfam00583  81 LQALLEWARERGCERIFLEVAADnlaAIALYEKLGF 116
PTZ00330 PTZ00330
acetyltransferase; Provisional
 67-125 1.14e-05

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 44.45  E-value: 1.14e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446397616  67 CEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNAREDAIPFYAKNGFERR 125
Cdd:PTZ00330  81 CVGHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKVILDCTEDMVAFYKKLGFRAC 139
PaaI COG2050
Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport ...
 162-297 6.65e-04

Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441653 [Multi-domain]  Cd Length: 138  Bit Score: 39.16  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616 162 DRWGKHIPISDKMGIKIQQYTGYQFQCCAQLNP-NLNPHNTLFAGSAFTLATLTGWGMAWLLMRERDLqgdIVLVDSHIR 240
Cdd:COG2050    9 EGFLAANPFAELLGIELVEVEPGRAVLRLPVRPeHLNPPGTVHGGALAALADSAAGLAANSALPPGRR---AVTIELNIN 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446397616 241 YRHPVVqnpvastsldgiSGDL-----DRLESGRKaRIVVRVIISSGEVEAI-EFIGTYMLIP 297
Cdd:COG2050   86 FLRPAR------------LGDRltaeaRVVRRGRR-LAVVEVEVTDEDGKLVaTATGTFAVLP 135
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 56-108 4.01e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 35.33  E-value: 4.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446397616  56 MAIGRLYITPDCEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCN 108
Cdd:cd04301   13 FASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
YiiD_C pfam09500
Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed ...
 157-297 1.33e-75

Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed uncharacterized domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain pfam00583.


Pssm-ID: 430649  Cd Length: 144  Bit Score: 227.91  E-value: 1.33e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  157 CTELQDRWGKHIPISDKMGIKIQQYTGYQFQCCAQLNPNLNPHNTLFAGSAFTLATLTGWGMAWLLMRERDLQGDIVLVD 236
Cdd:pfam09500   1 CQELQETWHDHIPLSRAMGIKVTQYDGQEFILSAPLAPNINHHGTMFAGSIYTLATLTGWGLLWLLLKEAGLEGDIVLAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446397616  237 SHIRYRHPVVQNPVASTSL---DGISGDLDRLESGRKARIVVRVIISSGEVEAIEFIGTYMLIP 297
Cdd:pfam09500  81 GNIRYLKPVTGDPTARVSLptpEAWSGFLSRLARGGKARITLEVEIYSGGELAAEFTGRYVVLK 144
yiiD_Cterm TIGR02447
thioesterase domain, putative; This family consists of a broadly distributed uncharacterized ...
 164-297 2.76e-51

thioesterase domain, putative; This family consists of a broadly distributed uncharacterized domain found often as a standalone protein. The member from Shewanella oneidensis, PDB|1T82_A (Forouhar, et al., unpublished) is described from crystallography work as a putative thioesterase. About half of the members of this family are fused to an Acetyltransf_1 domain (pfam00583). The function of this protein is unknown.


Pssm-ID: 131500  Cd Length: 138  Bit Score: 165.60  E-value: 2.76e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  164 WGKHIPISDKMGIKIQQYTGYQFQCCAQLNPNLNPHNTLFAGSAFTLATLTGWGMAWLLMRERDLQGDIVLVDSHIRYRH 243
Cdd:TIGR02447   2 LHSAIPLSEAMGIAVSSYTGGELRLSAPLAANINHHGTMFGGSLYTLATLSGWGLLWLRLQELGIDGDIVIADSHIRYLA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446397616  244 PVVQNPVAST---SLDGISGDLDRLESGRKARIVVRVIISSGEVEAIEFIGTYMLIP 297
Cdd:TIGR02447  82 PVTGDPVANCeapDLESWEAFLATLQRGGKARVKLEAQISSDGKLAATFSGEYVALP 138
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
10-145 4.98e-37

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 128.76  E-value: 4.98e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  10 DNQLNKYFHFRWQMLREPWRMPIGSERDEYDSMSHHRMIVDSrGYPMAIGRLYITPDCEGQIRYMAVKANRRSKGMGSLI 89
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDD-GELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446397616  90 LVALESLARQEGAKRLVCNAREDAIPFYAKNGFERRGELTDERGpVRHQQMVKTLD 145
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAG-IPHIDMRKPLS 134
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 48-145 1.68e-14

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 68.87  E-value: 1.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  48 IVDSRGYPMAIGRLYITPDCEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNAREDAIPFYAKNGFER--R 125
Cdd:COG1246   32 VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGFEEidK 111

                         90       100
                 ....*....|....*....|.
gi 446397616 126 GELTDERGPVRHQ-QMVKTLD 145
Cdd:COG1246  112 EDLPYAKVWQRDSvVMEKDLE 132
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 48-146 2.50e-11

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 60.45  E-value: 2.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  48 IVDSRGYPMAIGRLYITPDCEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRL---VCNAREDAIPFYAKNGFER 124
Cdd:COG0454   38 AVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALeldTLDGNPAAIRFYERLGFKE 117

                         90       100
                 ....*....|....*....|..
gi 446397616 125 RGELTDERGPvrhqQMVKTLDP 146
Cdd:COG0454  118 IERYVAYVGG----EFEKELSL 135
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 56-145 1.57e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 56.97  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  56 MAIGRLYITPDcEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNARED---AIPFYAKNGFERRGELTDER 132
Cdd:COG0456    2 FALLGLVDGGD-EAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDneaAIALYEKLGFEEVGERPNYY 80

                         90
                 ....*....|...
gi 446397616 133 GPVRHqQMVKTLD 145
Cdd:COG0456   81 GDDAL-VMEKELA 92
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
65-144 4.96e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.02  E-value: 4.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616  65 PDCEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNAREDAIPFYAKNGFERRGELTDERGPVRHqQMVKTL 144
Cdd:COG3153   64 EGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEV-FLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 13-122 4.56e-09

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 53.29  E-value: 4.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616   13 LNKYFHFRWQMLREPWRMPIGSERDEYDSMSHHRMIVDSR-GYPMAIGRLYITPD--CEGQIRYMAVKANRRSKGMGSLI 89
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEdGELVGFASLSIIDDepPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446397616   90 LVALESLARQEGAKRLVCNARED---AIPFYAKNGF 122
Cdd:pfam00583  81 LQALLEWARERGCERIFLEVAADnlaAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 48-124 1.24e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 51.30  E-value: 1.24e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446397616   48 IVDSRGYPMAIGRLYITPDCEGQIR-YMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNAREDAIPFYAKNGFER 124
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKLGFEE 84
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
55-129 1.14e-07

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 48.75  E-value: 1.14e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446397616  55 PMAIGRLYITPDCEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNARED---AIPFYAKNGFERRGELT 129
Cdd:COG3393    2 LVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADnpaARRLYERLGFRPVGEYA 79
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 58-144 7.07e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 47.65  E-value: 7.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616   58 IGRLYITPDCegqirymavkanrRSKGMGSLILVALESLARQEGAK--RLVCNAREDAIPFYAKNGFERRGELTDERGpV 135
Cdd:pfam13673  54 ISLLFVDPDY-------------QGQGIGKALLEAVEDYAEKDGIKlsELTVNASPYAVPFYEKLGFRATGPEQEFNG-I 119


                  ....*....
gi 446397616  136 RHQQMVKTL 144
Cdd:pfam13673 120 RFVPMEKEL 128
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
76-130 5.85e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 45.76  E-value: 5.85e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446397616  76 VKANRRSKGMGSLILVALESLARQEGAKRL---VCNAREDAIPFYAKNGFERRGELTD 130
Cdd:COG1247   88 VDPDARGRGIGRALLEALIERARARGYRRLvavVLADNEASIALYEKLGFEEVGTLPE 145
PTZ00330 PTZ00330
acetyltransferase; Provisional
 67-125 1.14e-05

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 44.45  E-value: 1.14e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446397616  67 CEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNAREDAIPFYAKNGFERR 125
Cdd:PTZ00330  81 CVGHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKVILDCTEDMVAFYKKLGFRAC 139
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 69-126 5.35e-04

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 39.69  E-value: 5.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446397616  69 GQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNAREDAIPFYAKNGFERRG 126
Cdd:PLN02706  86 GHIEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGYVRKE 143
PaaI COG2050
Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport ...
 162-297 6.65e-04

Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441653 [Multi-domain]  Cd Length: 138  Bit Score: 39.16  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397616 162 DRWGKHIPISDKMGIKIQQYTGYQFQCCAQLNP-NLNPHNTLFAGSAFTLATLTGWGMAWLLMRERDLqgdIVLVDSHIR 240
Cdd:COG2050    9 EGFLAANPFAELLGIELVEVEPGRAVLRLPVRPeHLNPPGTVHGGALAALADSAAGLAANSALPPGRR---AVTIELNIN 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446397616 241 YRHPVVqnpvastsldgiSGDL-----DRLESGRKaRIVVRVIISSGEVEAI-EFIGTYMLIP 297
Cdd:COG2050   86 FLRPAR------------LGDRltaeaRVVRRGRR-LAVVEVEVTDEDGKLVaTATGTFAVLP 135
PRK07922 PRK07922
amino-acid N-acetyltransferase;
69-123 1.02e-03

amino-acid N-acetyltransferase;


Pssm-ID: 236132 [Multi-domain]  Cd Length: 169  Bit Score: 39.13  E-value: 1.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446397616  69 GQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCNAREdaIPFYAKNGFE 123
Cdd:PRK07922  71 AEIRTVAVDPAARGRGVGHAIVERLLDVARELGLSRVFVLTFE--VEFFARHGFV 123
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 56-108 4.01e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 35.33  E-value: 4.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446397616  56 MAIGRLYITPDCEGQIRYMAVKANRRSKGMGSLILVALESLARQEGAKRLVCN 108
Cdd:cd04301   13 FASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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