|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-550 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 702.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 1 MDIKRSILLVALAVVAYLMVLQWNQDYGQAalptetaQSQPAAPAlpdspsattegnandvpavagqqqasalptsapss 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQA-------AAQAPAPQ----------------------------------- 38
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 81 QLIRVRTDVLDLAIDPRGGDIVELHLPQYPRRQDrPDVPFQLFERSSERTYEAQSGLIG-DGPD--KASGRPQYSSEKTE 157
Cdd:PRK01318 39 ARITVETDVLRLSIDTKGGRIDDLLLKKYKETLD-SSPPVVLLSPSTEHPYFAQSGLTGaDGPDnvPNPDRTLYTADGDS 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 158 YQLAEGQDALVVDLNYSA-DGVNYIKRFTLERGNYALKVNYLIDNQSQQPWTGYLFGQLKRDKSGDPSSstatgtATYLG 236
Cdd:PRK01318 118 LVLADGQNELPVTLTWTNgNGLTFTKTYTLDRGDYMFTVEYSVNNNSGAPVNLSPYGQLKRTGSSNFAS------YTFHG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 237 AALWTKDEPYRKVSMSNMDDKNlRETVQGGWIAWLQHYFVTAWIPQAGDtNQVQTRKDSQGNYIIGFTGPAVTVPAGAQG 316
Cdd:PRK01318 192 GAIGTPDEKYEKYTYKDIDDNL-NISSKGGWVAILDKYFATALIPQNGQ-NNFYSKNLGNGLYQVGFKSPPVTVAPGQSA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 317 ETGATLYAGPKSQDKLE-ELSPGLRLTVDYGILWFIAQPIFWLLQNIHALLGNWGWSIIVLTIVIKLAFFPLSAASYRSM 395
Cdd:PRK01318 270 STTARLYAGPKEVKLLAkEIAPGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSM 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 396 ARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWMFWITDLSI 475
Cdd:PRK01318 350 AKMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVSIELRHAPFIGWIHDLSA 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 476 KDPYFIL-----PIIMGVTMFIQQQLNPTPPDPMQARVMKLLPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYITRQIE 550
Cdd:PRK01318 430 PDPYFILhigllPILMGITMFLQQKLNPTPTDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLE 509
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
343-551 |
1.68e-122 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 358.66 E-value: 1.68e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 343 VDYGILWFIAQPIFWLLQNIHALLGNWGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQA 422
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 423 MMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWmFWITDLSIKDPYFI-LPIIMGVTMFIQQQLNPTP- 500
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPF-LGIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPa 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 500264326 501 PDPMQARVMKLLPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYITRQIEA 551
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDK 210
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-367 |
2.08e-119 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 357.03 E-value: 2.08e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 3 IKRSILLVALAVVAYLMVLQWNQDYGQAAL---PTETAQSQPAAPALPDSPSATTEGNANDVPAVAgqqqasalPTSAPS 79
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSDPGPPPPkppAAAQEASAASATAAATSAAAPAAADAPSAAAAA--------DAAAAT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 80 SQLIRVRTDVLDLAIDPRGGDIVELHLPQYPRRQDRPDVPFQLFERSSERTYEAQSGLIG-DGPDKA--SGRPQYSSEKT 156
Cdd:TIGR03593 73 AKRITVETDVLRASISTKGGDIDSLELKKYKETLDKDSPPVLLLSDGAERLYVAQSGLIGaNGADLAlpGHRTVWQAEGG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 157 EYQLAEGQdaLVVDLNY-SADGVNYIKRFTLERGNYALKVNYLIDNQSQQPWTGYLFGQLKRDKSgDPSSSTATGTATYL 235
Cdd:TIGR03593 153 EYTLTPGQ--LPVTLTWdNSNGVTVTKTYTFDRDSYLIDVEYKVTNNGDAPVSLSLYGQLKRDLS-PTEKSTYFLHETFT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 236 GAALWTKDEPYRKVSMSNMDDKNLRETVQG--GWIAWLQHYFVTAWIPQAGDTNQVQT---RKDSQGNYIIGFTGPAVTV 310
Cdd:TIGR03593 230 GAAYYTDGEKYQKVSFKDIEKKKLNVETKGgaGWVGMLQHYFASAWIPPAGSDGTTAFyygRKLGNNVYIAGFVSPVVTV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 500264326 311 PAGAQGETGATLYAGPKSQDKLEELSPGLRLTVDYGILWFIAQPIFWLLQNIHALLG 367
Cdd:TIGR03593 310 APGQSATIKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
369-547 |
1.75e-103 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 309.40 E-value: 1.75e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 369 WGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVF 448
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 449 LALYWVLLESVEMRQAPWMFWITDLSIKDP-----YFILPIIMGVTMFIQQQLNPTPPD-PMQARVMKL--LPIIFTFFF 520
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDqPPQMKMMMLyfMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 500264326 521 LWFPAGLVLYWVVNNILSIAQQWYITR 547
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
370-547 |
1.36e-101 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 304.30 E-value: 1.36e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 370 GWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFL 449
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 450 ALYWVLLESVEMRQAPWMFWITDLSIKDPYFILPIIMGVTMFIQQQLNPTPPD---PMQARVMKLLPIIFTFFFLWFPAG 526
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqaPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 500264326 527 LVLYWVVNNILSIAQQWYITR 547
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-550 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 702.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 1 MDIKRSILLVALAVVAYLMVLQWNQDYGQAalptetaQSQPAAPAlpdspsattegnandvpavagqqqasalptsapss 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQA-------AAQAPAPQ----------------------------------- 38
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 81 QLIRVRTDVLDLAIDPRGGDIVELHLPQYPRRQDrPDVPFQLFERSSERTYEAQSGLIG-DGPD--KASGRPQYSSEKTE 157
Cdd:PRK01318 39 ARITVETDVLRLSIDTKGGRIDDLLLKKYKETLD-SSPPVVLLSPSTEHPYFAQSGLTGaDGPDnvPNPDRTLYTADGDS 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 158 YQLAEGQDALVVDLNYSA-DGVNYIKRFTLERGNYALKVNYLIDNQSQQPWTGYLFGQLKRDKSGDPSSstatgtATYLG 236
Cdd:PRK01318 118 LVLADGQNELPVTLTWTNgNGLTFTKTYTLDRGDYMFTVEYSVNNNSGAPVNLSPYGQLKRTGSSNFAS------YTFHG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 237 AALWTKDEPYRKVSMSNMDDKNlRETVQGGWIAWLQHYFVTAWIPQAGDtNQVQTRKDSQGNYIIGFTGPAVTVPAGAQG 316
Cdd:PRK01318 192 GAIGTPDEKYEKYTYKDIDDNL-NISSKGGWVAILDKYFATALIPQNGQ-NNFYSKNLGNGLYQVGFKSPPVTVAPGQSA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 317 ETGATLYAGPKSQDKLE-ELSPGLRLTVDYGILWFIAQPIFWLLQNIHALLGNWGWSIIVLTIVIKLAFFPLSAASYRSM 395
Cdd:PRK01318 270 STTARLYAGPKEVKLLAkEIAPGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSM 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 396 ARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWMFWITDLSI 475
Cdd:PRK01318 350 AKMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVSIELRHAPFIGWIHDLSA 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 476 KDPYFIL-----PIIMGVTMFIQQQLNPTPPDPMQARVMKLLPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYITRQIE 550
Cdd:PRK01318 430 PDPYFILhigllPILMGITMFLQQKLNPTPTDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLE 509
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
343-551 |
1.68e-122 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 358.66 E-value: 1.68e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 343 VDYGILWFIAQPIFWLLQNIHALLGNWGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQA 422
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 423 MMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWmFWITDLSIKDPYFI-LPIIMGVTMFIQQQLNPTP- 500
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPF-LGIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPa 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 500264326 501 PDPMQARVMKLLPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYITRQIEA 551
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDK 210
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-367 |
2.08e-119 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 357.03 E-value: 2.08e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 3 IKRSILLVALAVVAYLMVLQWNQDYGQAAL---PTETAQSQPAAPALPDSPSATTEGNANDVPAVAgqqqasalPTSAPS 79
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSDPGPPPPkppAAAQEASAASATAAATSAAAPAAADAPSAAAAA--------DAAAAT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 80 SQLIRVRTDVLDLAIDPRGGDIVELHLPQYPRRQDRPDVPFQLFERSSERTYEAQSGLIG-DGPDKA--SGRPQYSSEKT 156
Cdd:TIGR03593 73 AKRITVETDVLRASISTKGGDIDSLELKKYKETLDKDSPPVLLLSDGAERLYVAQSGLIGaNGADLAlpGHRTVWQAEGG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 157 EYQLAEGQdaLVVDLNY-SADGVNYIKRFTLERGNYALKVNYLIDNQSQQPWTGYLFGQLKRDKSgDPSSSTATGTATYL 235
Cdd:TIGR03593 153 EYTLTPGQ--LPVTLTWdNSNGVTVTKTYTFDRDSYLIDVEYKVTNNGDAPVSLSLYGQLKRDLS-PTEKSTYFLHETFT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 236 GAALWTKDEPYRKVSMSNMDDKNLRETVQG--GWIAWLQHYFVTAWIPQAGDTNQVQT---RKDSQGNYIIGFTGPAVTV 310
Cdd:TIGR03593 230 GAAYYTDGEKYQKVSFKDIEKKKLNVETKGgaGWVGMLQHYFASAWIPPAGSDGTTAFyygRKLGNNVYIAGFVSPVVTV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 500264326 311 PAGAQGETGATLYAGPKSQDKLEELSPGLRLTVDYGILWFIAQPIFWLLQNIHALLG 367
Cdd:TIGR03593 310 APGQSATIKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| yidC_oxa1_cterm |
TIGR03592 |
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ... |
368-545 |
1.13e-104 |
|
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274665 [Multi-domain] Cd Length: 179 Bit Score: 312.11 E-value: 1.13e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 368 NWGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPV 447
Cdd:TIGR03592 1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 448 FLALYWVLLESVEMRQAPWmFWITDLSIKDPYFILPIIMGVTMFIQQQLNPT-PPDPMQARVM-KLLPIIFTFFFLWFPA 525
Cdd:TIGR03592 81 FIALYQVLLRSIELRHAPF-LWIIDLSSPDPYYILPILMGVTMFLQQKLSPKgPPDPAQQKMMmYFMPLMFLFFFLSFPA 159
|
170 180
....*....|....*....|
gi 500264326 526 GLVLYWVVNNILSIAQQWYI 545
Cdd:TIGR03592 160 GLVLYWVVSNLFTIIQQLII 179
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
369-547 |
1.75e-103 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 309.40 E-value: 1.75e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 369 WGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVF 448
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 449 LALYWVLLESVEMRQAPWMFWITDLSIKDP-----YFILPIIMGVTMFIQQQLNPTPPD-PMQARVMKL--LPIIFTFFF 520
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDqPPQMKMMMLyfMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 500264326 521 LWFPAGLVLYWVVNNILSIAQQWYITR 547
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| YidC_periplas |
pfam14849 |
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein ... |
83-345 |
1.41e-102 |
|
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins.
Pssm-ID: 464346 Cd Length: 266 Bit Score: 309.97 E-value: 1.41e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 83 IRVRTDVLDLAIDPRGGDIVELHLPQYPRRQDRPDVPFQLFERSSERTYEAQSGLIG-DGPDKASGRPQYSSEKTEYQLA 161
Cdd:pfam14849 1 ITVETDVLRGSISLKGGRIDDLELKKYRETLDDDSPPVVLLSPSGGRTYVAQSGLIGaGGPDLPPHDTVFTAEGGSYTLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 162 EGQDALVVDLNYSA-DGVNYIKRFTLERGNYALKVNYLIDNQSQQPWTGYLFGQLKRDKSGDPSSStatGTATYLGAALW 240
Cdd:pfam14849 81 DGTDELPVTLTWDNgNGVTFTKTYTFDRGSYLIDVTYEVENTSGAPVTLQPYGQLVRDPGEPEGSS---FYITYTGAAGS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 241 TKDEPYRKVSMSNMDD---KNLRETVQGGWIAWLQHYFVTAWIP-QAGDTNQVQTRKDSQGNYIIGFTGPAVTVPAGAQG 316
Cdd:pfam14849 158 TDEGKYQKVSFDDIEKggkLKVDTTTGGGWVAMTQHYFLSAWIPdQDGTTNEFYTRFLGGNLYQAGYISPAVTVAPGASA 237
|
250 260
....*....|....*....|....*....
gi 500264326 317 ETGATLYAGPKSQDKLEELSPGLRLTVDY 345
Cdd:pfam14849 238 TVTARLFAGPKEQKVLEAIAPGLDLAVDY 266
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
370-547 |
1.36e-101 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 304.30 E-value: 1.36e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 370 GWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFL 449
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 450 ALYWVLLESVEMRQAPWMFWITDLSIKDPYFILPIIMGVTMFIQQQLNPTPPD---PMQARVMKLLPIIFTFFFLWFPAG 526
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqaPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 500264326 527 LVLYWVVNNILSIAQQWYITR 547
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| EcYidC-like_peri |
cd19961 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
81-345 |
1.38e-66 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Escherichia coli and similar domains; This subfamily is composed of Escherichia coli YidC and similar proteins. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contain a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich.
Pssm-ID: 411000 Cd Length: 255 Bit Score: 216.41 E-value: 1.38e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 81 QLIRVRTDVLDLAIDPRGGDIVELHLPQYPRRQDrPDVPFQLFerSSERTYEAQSGLIG-DGPDKASGRPQYSSEKTEYq 159
Cdd:cd19961 1 KRITVETDLLKASISTKGGRIKSVELKKYKETLP-DSKPVELL--SPDGPYVAQLGLIGaDGPLIPTADLLFTADSGSY- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 160 laEGQDALVVDLNY-SADGVNYIKRFTLERGNYALKVNYLIDNQSQQPWTGYLFGQLKRDksgDPSSSTATGTATYLGAA 238
Cdd:cd19961 77 --EGGDSLTVTLTWtNGDGLTIEKTYTFDPDSYLIDVEVRVENNSSAPLSLSLYLQLQRK---GGEPEGSGSTITYEGPA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 239 lWTKDEPYRKVSMSNMDDKNLrETVQGGWIAWLQHYFVTAWIPQAGDTNQVQTRKDsQGNYIIGFTGPAVTVPAGAQGET 318
Cdd:cd19961 152 -GTEDGKLEKLSFKDLEEEKL-SSGKVGWVAFKQKYFLSALIPDQGFFYSAKLSGK-DDGDGVKLLSAALTLPPGGSGTF 228
|
250 260
....*....|....*....|....*..
gi 500264326 319 GATLYAGPKSQDKLEELSPGLRLTVDY 345
Cdd:cd19961 229 SFRLYAGPKDYDILKAYGPGLELAVDF 255
|
|
| 5TM_YidC_Oxa1_Alb3 |
cd19751 |
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ... |
370-547 |
1.35e-60 |
|
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410992 [Multi-domain] Cd Length: 189 Bit Score: 198.55 E-value: 1.35e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 370 GWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDD------RQKMSQAMMELYKKEKINPLGGCLPILV 443
Cdd:cd19751 1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYKEKaskdkvQQEMQKEMLGLYKKHGVNPMAGCLPLFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 444 QMPVFLALYWVLLESVEMRQAPWMfWITDLSIKDPYFILPIIMGVTMFIQQQLNPT------PPDPMQARVMKLLPIIFT 517
Cdd:cd19751 81 QLPIFMAFYFAIMRTEEIRYHTFL-WFFDLGQPDYLYILPFVAGITTYFQFKMTMShqqqmqMMQMQMKVMLYVMPVMII 159
|
170 180 190
....*....|....*....|....*....|
gi 500264326 518 FFFLWFPAGLVLYWVVNNILSIAQQWYITR 547
Cdd:cd19751 160 IAGLSFPSALSLYWIISNLFMIIQTYFIVR 189
|
|
| PRK00145 |
PRK00145 |
putative inner membrane protein translocase component YidC; Provisional |
361-551 |
2.45e-47 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234665 [Multi-domain] Cd Length: 223 Bit Score: 164.53 E-value: 2.45e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 361 NIHALLGNWGWS----IIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLG 436
Cdd:PRK00145 19 FVSSVISNPNFSygiaIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPLG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 437 GCLPILVQMPVFLALYWVLLESVEMRQAPWMfWITDLSIKDPYFILPIIMGVTMFIQQQLNpTPPDPMQARVMKLLPIIF 516
Cdd:PRK00145 99 GCLPLLIQWPILIALYYVFNNLTGINGVSFL-WIKDLAKPDITWILPILSGATTYLSGYLM-TKADSSQAGQMKTMNIGM 176
|
170 180 190
....*....|....*....|....*....|....*....
gi 500264326 517 TFFFLW----FPAGLVLYWVVNNILSIAQQwYITRQIEA 551
Cdd:PRK00145 177 SIFMGVmswkFKSALVLYWVIGNLIQIIQT-YFIKKLEL 214
|
|
| PRK02944 |
PRK02944 |
YidC family membrane integrase SpoIIIJ; |
350-546 |
4.30e-47 |
|
YidC family membrane integrase SpoIIIJ;
Pssm-ID: 179508 Cd Length: 255 Bit Score: 164.94 E-value: 4.30e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 350 FIAQPIFWLLQNIHALLG-NWGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDD----RQKMSQAMM 424
Cdd:PRK02944 39 YFVYPLSQLITYFANLFGsNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYSSKdqatQQKLQQEMM 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 425 ELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWMFWitDLSIKDPYFILPIIMGVTMFIQQQL----NPTp 500
Cdd:PRK02944 119 QLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSFLWF--DLGQADPYYILPIVAGITTFIQQKLmmagTAG- 195
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 500264326 501 PDPMQARVMKLLPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYIT 546
Cdd:PRK02944 196 QNPQMAMMLWLMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLIK 241
|
|
| PRK01001 |
PRK01001 |
putative inner membrane protein translocase component YidC; Provisional |
322-551 |
1.26e-46 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234887 [Multi-domain] Cd Length: 795 Bit Score: 174.60 E-value: 1.26e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 322 LYAGP------KSQDKLEELSPGLrlTVDY-------GILWFIAQP----IFWLLQNIHALLGNWGWSIIVLTIVIKLAF 384
Cdd:PRK01001 514 VYAGPladptlKTLDRAYTNSKGE--NPEYldsitfrGFFSFITEPfaalLFIIMKFFKFLTGSWGISIILLTVFLKLLL 591
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 385 FPLSAASYRSMARMRAVSPKMQALKEQFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQA 464
Cdd:PRK01001 592 YPLNAWSIRSMRRMQKLSPYIQEIQQKYKKEPKRAQMEIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLKSSFLLRGA 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 465 PWM-FWITDLSIKDPYF--------------ILPIIMGVTMFIQQQLNPT-PPDPM-----QARVM-KLLPIIFTFFFLW 522
Cdd:PRK01001 672 SFIpGWIDNLTAPDVLFswetpiwfignefhLLPILLGVVMFAQQKISSLkRKGPVtdqqrQQEAMgTMMALLFTFMFYN 751
|
250 260
....*....|....*....|....*....
gi 500264326 523 FPAGLVLYWVVNNILSIAQQWYITRQIEA 551
Cdd:PRK01001 752 FPSGLNIYWLSSMLLGVIQQWVTNKILDS 780
|
|
| 5TM_Oxa1-like |
cd20069 |
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ... |
369-543 |
2.16e-43 |
|
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410993 [Multi-domain] Cd Length: 201 Bit Score: 153.45 E-value: 2.16e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 369 WGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQF------GDD--RQKMSQAMMELYKKEKINPLGGCLP 440
Cdd:cd20069 4 WWATIAATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEKLkearasGDQleAAEARKELKELMKKHNVNPLKSLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 441 ILVQMPVFLALYWVL-----LESVEMRQAPwMFWITDLSIKDPYFILPIIMGVTMFI------QQQLNPTPPDPMQARVM 509
Cdd:cd20069 84 PLVQAPVFISFFFALrkmanLPVPSFKTGG-LLWFTDLTVPDPYYILPILTSLTFLAtielgaETGTSGSPQSKTMKNVF 162
|
170 180 190
....*....|....*....|....*....|....
gi 500264326 510 KLLPIIFTFFFLWFPAGLVLYWVVNNILSIAQQW 543
Cdd:cd20069 163 RGLPVLMIPFTANFPSAVFLYWITSNLFSLAQNL 196
|
|
| PRK01315 |
PRK01315 |
putative inner membrane protein translocase component YidC; Provisional |
347-556 |
9.98e-42 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234941 Cd Length: 329 Bit Score: 152.97 E-value: 9.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 347 ILWFIAQPIFWLLQNI----HALLG---------NWGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFG 413
Cdd:PRK01315 7 FGSAIMTPLYWVISGIlvlfHTLLGflfgpdsglTWVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEKYK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 414 DDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEmRQAPWMFWITDL--SIKDPYF----------- 480
Cdd:PRK01315 87 GDRERMSQEMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAAS-RGDGIGPINPPLleSFRHAHIfgaplaatflq 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 481 --------------ILPIIMGVTMFIQQ-QLNP--TPPD----PM---QARVMKLLPIIFTFFFLWFPAGLVLYWVVNNI 536
Cdd:PRK01315 166 alnagntavqvvaaVLIILMSASQFITQlQLMTknMPPEaktgPMaqqQKMLLYLFPLMFLVSGIAFPVGVLFYWLTSNV 245
|
250 260
....*....|....*....|
gi 500264326 537 LSIAQQWYITRQIEAGAKPA 556
Cdd:PRK01315 246 WTMGQQFYVIRNNPTPGSPA 265
|
|
| PRK01622 |
PRK01622 |
membrane protein insertase YidC; |
350-541 |
2.39e-35 |
|
membrane protein insertase YidC;
Pssm-ID: 179310 Cd Length: 256 Bit Score: 133.34 E-value: 2.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 350 FIAQPIFWLLQNIHALL-GNWGWSIIVLTIVIKLAFFPLSAASYRSM----ARMRAVSPKMQALKEQFGDDRQKMSQA-- 422
Cdd:PRK01622 40 YFVYPFSFLIQFVAHHIgGSYGIAIIIVTLIIRSLMIPLAVSQYKSQrgmqEKMAVMKPELDKIQAKLKVTKDLEKQKey 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 423 ---MMELYKKEKINPLG-GCLPILVQMPVFLALYWVLLESVEMRQAPWMfWItdlSIKDPYFILPIIMGVTMFIQ---QQ 495
Cdd:PRK01622 120 qkeMMELYKSGNINPLAmGCLPLLIQMPILSAFYYAIRRTEEIASHSFL-WF---NLGHADHILPIIAGLTYFIQmkvSQ 195
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 500264326 496 LNPTPPDPMQ-ARVMKLL-PIIFTFFFLWFPAGLVLYWVVNNILSIAQ 541
Cdd:PRK01622 196 SNGTSPEQVQmLKIQGIMmPAMILFMSFAAPSALVLYWITGGLFLMGQ 243
|
|
| PRK03449 |
PRK03449 |
putative inner membrane protein translocase component YidC; Provisional |
348-551 |
8.83e-27 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 179580 Cd Length: 304 Bit Score: 110.54 E-value: 8.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 348 LWFIAQPIFWLLQNIHALLG---------NWGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQALKEQFGDDRQK 418
Cdd:PRK03449 2 LDFIYYPVSAILWFWHKLFSfvlgpdngfAWALSVMFLVFTLRALLYKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 419 MSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLE-------------SVEMRQ---------------------- 463
Cdd:PRK03449 82 MALEMQKLQKEHGFNPILGCLPMLAQIPVFLGLFHVLRSfnrtgtgfgqlgmSVEENRntpnyvfsaedvqsfldarlfg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 464 APWMFWITDLSIKDPYFI-------------LPIIMGVTMF------IQQQLNPTPPDPMQARVMKL------LPIIFTF 518
Cdd:PRK03449 162 APLSAYITMPRSGLDAFVdftrtniilvgvpLMIIAGVATHfnsrasVARQSAEAAANPQTAMMNKLalwvfpLGVLVGG 241
|
250 260 270
....*....|....*....|....*....|...
gi 500264326 519 FFLwfPAGLVLYWVVNNILSIAQQWYITRQIEA 551
Cdd:PRK03449 242 PFL--PLAILLYWVSNNIWTFGQQHYVFGKIDK 272
|
|
| PRK02654 |
PRK02654 |
putative inner membrane protein translocase component YidC; Provisional |
368-455 |
1.63e-26 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235058 Cd Length: 375 Bit Score: 111.23 E-value: 1.63e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 368 NWGWSIIVLTIVIKLAFFPLSAASYRSMARMRAVSPKMQA----LKEQFGDDRQKMSQAMMELYkKEKINPLGGCLPILV 443
Cdd:PRK02654 26 SYGLAIVALTLVIRFALYPLSAGSIRNMRRMKIAQPVMQKrqaeIQERYKNDPQKQQEEMGKLM-KEFGNPLAGCLPLLV 104
|
90
....*....|..
gi 500264326 444 QMPVFLALYWVL 455
Cdd:PRK02654 105 QMPILFALFATL 116
|
|
| PRK02463 |
PRK02463 |
OxaA-like protein precursor; Provisional |
345-546 |
3.73e-26 |
|
OxaA-like protein precursor; Provisional
Pssm-ID: 235040 Cd Length: 307 Bit Score: 108.66 E-value: 3.73e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 345 YGILW-FIAQP----IFWLLQNIHalLGnWGWSIIVLTIVIKLAFFPLSAASYRSMARMravSPKMQALKEQFGDDRQKM 419
Cdd:PRK02463 34 TGFIWnFLGAPmsyfIDYFANNLG--LG-FGLAIIIVTIIVRLIILPLGLYQSWKATYQ---SEKMAYLKPVFEPINERL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 420 ------------SQAMMELYKKEKINPLG--GCLPILVQMPVFLALYWVLLESVEMRQAPWMfWItDLSikDPYFILPII 485
Cdd:PRK02463 108 knattqeekmaaQTELMAAQRENGISMLGgiGCLPLLIQMPFFSALYFAAQYTKGVSTSTFL-GI-DLG--SPSLVLTAI 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500264326 486 MGVTMFIQQQLNPTPPDPMQARVMK----LLPIIFTFFFLWFPAGLVLYWVVNNILSIAQQWYIT 546
Cdd:PRK02463 184 IGVLYFFQSWLSMMGVPEEQREQMKammyMMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLITT 248
|
|
| PRK02201 |
PRK02201 |
putative inner membrane protein translocase component YidC; Provisional |
350-541 |
1.54e-19 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235012 Cd Length: 357 Bit Score: 90.46 E-value: 1.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 350 FIAQPIFWLLQNIHALLGNWGW-------SIIVLTIVIKLAFFPLSAASYRSMARMRAVSPK---MQALKEQFGDD---R 416
Cdd:PRK02201 107 LFVYPIAQIILSIMASQSLSELygwstilAIIVVVLIIRLISFLITFKSTFNQEKQEELQGKkakIDAKYKDYKKDkqmK 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 417 QKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLLESVEMRQAPWmFWItDLSiKDPY-----------FILPII 485
Cdd:PRK02201 187 QRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQSLPSIKVTTW-LGI-DLS-ATSWqeifagnwiylPILIIV 263
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500264326 486 MGV---TMFIQQQLN-------PTPPDPMQA-----RVMKLLPIIFTFFFLWFPAGLVLYWVVNNILSIAQ 541
Cdd:PRK02201 264 VPVqalSQLLPQILNkkknkerTLNVKEKEAlkkqnKTQNIISIVFIFFGVIFAAGVQIYWIIGGIWTILQ 334
|
|
| PRK00247 |
PRK00247 |
putative inner membrane protein translocase component YidC; Validated |
347-456 |
1.84e-12 |
|
putative inner membrane protein translocase component YidC; Validated
Pssm-ID: 178945 [Multi-domain] Cd Length: 429 Bit Score: 69.49 E-value: 1.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 347 ILWFIAQPIFWLLQNIHALLGN---------WGWSIIVLTIVIKLAFFPLSAASYRS---MARMRavsPKMQALKEQFGD 414
Cdd:PRK00247 1 MLDIFIYPVSGVMKLWHLLLHNvlglddslaWFASLFGLVITVRAIIAPFTWQQYKSgrtAAHIR---PKRKALREEYKG 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 500264326 415 -----DRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLALYWVLL 456
Cdd:PRK00247 78 ktdeaSIRELQQKQKDLNKEYGYNPLAGCVPALIQIPVFLGLYQVLL 124
|
|
| YidC_peri |
cd19960 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
82-344 |
6.35e-10 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Gram-negative bacteria and similar domains; Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contains a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich. Other members of the YidC/Oxa1/Alb3 family include YidC1/YidC2 from gram-positive bacteria as well as eukaryotic members such as mitochondrial Oxa1/Oxa2 (or Cox18) and chloroplastic Alb3/Alb4; they are not part of this hierarchy as they do not possess the periplasmic domain.
Pssm-ID: 410999 Cd Length: 233 Bit Score: 59.57 E-value: 6.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 82 LIRVRTDVLDLAIDPRGgDIVELHLPQYPRRQDRPdvpFQLFERSSErtyeAQSGL-IGDGPDK----ASGRPQYSSEKt 156
Cdd:cd19960 2 IATVKSKDFELTIDTLG-RISQFYLKDKKYKNEDG---KQLELISPQ----APKPLeIRFSDPAlneeAFKTPYTASVS- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 157 eyQLAEGQDALVVDLNYSADGVNYIKRFTLER-GNYALKVNYLIDNqsqqPWTGYLfGQlkRDKSGDPSSSTAtgtatyl 235
Cdd:cd19960 73 --EIDLESGPQSVVLTQTLSGLTVTKTITFYPdGHYDVKVKLSKPV----DYFITP-GQ--RPNAAVDSYTVH------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500264326 236 GAALWTKDEPYRKVSmsNMDDKNLRETVQGGWIAWLQHYFVTAWIPQAGDTNQVQTrKDSQGNyiigftgPAVTVpaGAQ 315
Cdd:cd19960 137 GALVKTADGTITIIE--DGDAEGTESFSNVNIAASFDRYYATLFYNFDKGLNVVVT-KDASDN-------PLVFV--KGN 204
|
250 260
....*....|....*....|....*....
gi 500264326 316 GETGATLYAGPKSQDKLEELSPGLRLTVD 344
Cdd:cd19960 205 GNFSLHGYIGPKEYKLLKSIDPELTDVIE 233
|
|
| |
