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Conserved domains on  [gi|503915558|ref|WP_014149552|]
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cell division protein ZapE [Methylotuvimicrobium alcaliphilum]

Protein Classification

AFG1/ZapE family ATPase( domain architecture ID 11445240)

AFG1/ZapE family ATPase similar to cell division protein ZapE, that interacts with FtsZ and modulates the Z-ring dynamics

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ZapE COG1485
Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, ...
18-376 7.90e-179

Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 441094  Cd Length: 365  Bit Score: 500.78  E-value: 7.90e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  18 AGESLLVEYRWRVEQGLIDYDPAQVEALHYLQEMLDKLTA--ENRSGFLS---LSSARGKPCKSLYIYGGVGRGKSMLMD 92
Cdd:COG1485    1 MMMSPLERYQALLAAGGLQPDPAQEAAVARLDRLYDELLAyrPRKSGLLGrlfGRKRKPEPPKGLYLWGGVGRGKTMLMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  93 LFYDHCPIQEKRRVHFHTFILEVHEFSHRWRQEKkqDIIHSLAAEINASTKLLCFDEFHVIDVANAVILDRLFSRLFELG 172
Cdd:COG1485   81 LFFESLPVERKRRVHFHRFMQEVHARLHALRGQA--DPLPPVADRIAAEARLLCFDEFHVTDIADAMILGRLFEALFARG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 173 TVIVTTSNRHPDDLYQAGLVPELFLKFIELLKASADVVELVAKHDYRLTRIHGAEkTYFYPLDEHAASALEQCYRELTHS 252
Cdd:COG1485  159 VVLVATSNIPPDDLYKNGLQRARFLPFIALIKQHLDVLNLDSGTDYRLRRLEGAP-VYHTPLDAEADAALDAAFARLTGG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 253 APLKPYSLKVLGRNVVLRAAHGDVAFTTFDEVCRKPLGPADYLKIVQAFRVVIVSGIPRFGFDNHDEAKRFSTLVDALYF 332
Cdd:COG1485  238 APEEPETLEVNGREIPVPRAAGGVAWFDFADLCGGPRGQADYLELARRFHTVILSDVPVMGPDNRNEARRFITLIDELYD 317
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 503915558 333 HKVILICSAEAPARELYDENIRAFFLKRTVSRLIEMQSDYYLKQ 376
Cdd:COG1485  318 RRVKLIASAAAPPEELYTGGRGAFEFERTASRLIEMQSEEYLAL 361
 
Name Accession Description Interval E-value
ZapE COG1485
Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, ...
18-376 7.90e-179

Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441094  Cd Length: 365  Bit Score: 500.78  E-value: 7.90e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  18 AGESLLVEYRWRVEQGLIDYDPAQVEALHYLQEMLDKLTA--ENRSGFLS---LSSARGKPCKSLYIYGGVGRGKSMLMD 92
Cdd:COG1485    1 MMMSPLERYQALLAAGGLQPDPAQEAAVARLDRLYDELLAyrPRKSGLLGrlfGRKRKPEPPKGLYLWGGVGRGKTMLMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  93 LFYDHCPIQEKRRVHFHTFILEVHEFSHRWRQEKkqDIIHSLAAEINASTKLLCFDEFHVIDVANAVILDRLFSRLFELG 172
Cdd:COG1485   81 LFFESLPVERKRRVHFHRFMQEVHARLHALRGQA--DPLPPVADRIAAEARLLCFDEFHVTDIADAMILGRLFEALFARG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 173 TVIVTTSNRHPDDLYQAGLVPELFLKFIELLKASADVVELVAKHDYRLTRIHGAEkTYFYPLDEHAASALEQCYRELTHS 252
Cdd:COG1485  159 VVLVATSNIPPDDLYKNGLQRARFLPFIALIKQHLDVLNLDSGTDYRLRRLEGAP-VYHTPLDAEADAALDAAFARLTGG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 253 APLKPYSLKVLGRNVVLRAAHGDVAFTTFDEVCRKPLGPADYLKIVQAFRVVIVSGIPRFGFDNHDEAKRFSTLVDALYF 332
Cdd:COG1485  238 APEEPETLEVNGREIPVPRAAGGVAWFDFADLCGGPRGQADYLELARRFHTVILSDVPVMGPDNRNEARRFITLIDELYD 317
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 503915558 333 HKVILICSAEAPARELYDENIRAFFLKRTVSRLIEMQSDYYLKQ 376
Cdd:COG1485  318 RRVKLIASAAAPPEELYTGGRGAFEFERTASRLIEMQSEEYLAL 361
ZapE NF040713
cell division protein ZapE;
26-369 3.07e-153

cell division protein ZapE;


Pssm-ID: 468677 [Multi-domain]  Cd Length: 344  Bit Score: 435.41  E-value: 3.07e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  26 YRWRVEQGLIDYDPAQVEALHYLQEMLDKLTA--ENRSGFLSLSSARGKPCKSLYIYGGVGRGKSMLMDLFYDHCPIQEK 103
Cdd:NF040713   2 YEAAVAFGGYRPDPAQAAAVERLDRLAEELAApaKKRGLLGRLFGRKKSPPRGLYLWGGVGRGKTMLMDLFYEALPIERK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 104 RRVHFHTFILEVHEFSHRWRQEKkqDIIHSLAAEINASTKLLCFDEFHVIDVANAVILDRLFSRLFELGTVIVTTSNRHP 183
Cdd:NF040713  82 RRVHFHEFMREVHQRLALLRGQA--DPLPPVADEIASEARLLCFDEFHVDDIADAMILGRLFEALFERGVVLVATSNTPP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 184 DDLYQAGLVPELFLKFIELLKASADVVELVAKHDYRLTRIHGAEkTYFYPLDEHAASALEQCYRELTHSAPLKPYSLKVL 263
Cdd:NF040713 160 DDLYKNGLNRERFLPAIALIKAHFDVVNVDGGTDYRLRRLEQAP-VYLTPLDAEADAALDAAFARLTGGAAAEPGTLEVN 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 264 GRNVVLRAAHGDVAFTTFDEVCRKPLGPADYLKIVQAFRVVIVSGIPRFGFDNHDEAKRFSTLVDALYFHKVILICSAEA 343
Cdd:NF040713 239 GRELPVPRAAGGVAWFDFADLCEAPRSPSDYLALARRFHTVLLSGVPPLGDESRDAARRFIALIDELYDRKVKLIISAEV 318
                        330       340
                 ....*....|....*....|....*.
gi 503915558 344 PARELYDENIRAFFLKRTVSRLIEMQ 369
Cdd:NF040713 319 PLEELYTEGGLAFEFERTLSRLQEMQ 344
AFG1_ATPase pfam03969
AFG1-like ATPase; This P-loop motif-containing family of proteins includes AFG1, LACE1 and ...
21-375 2.23e-90

AFG1-like ATPase; This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE. ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family. LACE1, the mammalian homolog of AFG1, is a mitochondrial integral membrane protein that is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. It has also been demonstrated that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4 (cytochrome c oxidase 4), COX5A and COX6A, and is required for normal activity of complexes III and IV of the respiratory chain. ZapE is a cell division protein found in Gram-negative bacteria. The bacterial cell division process relies on the assembly, positioning, and constriction of FtsZ ring (the so-called Z-ring), a ring-like network that marks the future site of the septum of bacterial cell division. ZapE is a Z-ring associated protein required for cell division under low-oxygen conditions. It is an ATPase that appears at the constricting Z-ring late in cell division. It reduces the stability of FtsZ polymers in the presence of ATP in vitro.


Pssm-ID: 397872  Cd Length: 361  Bit Score: 275.92  E-value: 2.23e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558   21 SLLVEYRWRVEQGLIDYDPAQVEALHYLQEMLDKLTAenrSGFLSLSSARGK---------PCKSLYIYGGVGRGKSMLM 91
Cdd:pfam03969   2 TPPVRYIADLQRPDFFPDVAQANAVPHLDRLYQDLAA---QDFPRPARAGGKlwgrkpsvqPPRGLYLWGGVGRGKTWLM 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558   92 DLFYDHCPIQEKRRVHFHTFILEVHEFSHRWRQEKK--QDIIHSLAAEinasTKLLCFDEFHVIDVANAVILDRLFSRLF 169
Cdd:pfam03969  79 DLFFESLPGEKKRRTHFHRFMFRVHDELTTLQGGVDplAIIADRLAGE----ARLLCFDEFFVSDIGDAMLLGRLFEALF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  170 ELGTVIVTTSNRHPDDLYQAGLVPELFLKFIELLKASADVVELVAKHDYRLTRIHGAEkTYFYPLDEHAASALEQCYREL 249
Cdd:pfam03969 155 ARGVTLVATSNIAPEQLYKNGLQRARFLPAIDLLKSHCEVVNVDGGVDYRLRTLRQAE-LWLYPLDGYCWAAMDRLWDAL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  250 THSAPLKPYSLKVLGRNVVLRAAHGDVAFTTFDEVCRKPLGPADYLKIVQAFRVVIVSGIPRFGFDNHDEAKRFSTLVDA 329
Cdd:pfam03969 234 GLGEPEPLSTLEVNARALRARAVGGDLVWFSFACLCQAARSQNDYLALAERFHTVFLEDVPQMTRCSDDAARRFIALVDE 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 503915558  330 LYFHKVILICSAEAPARELYDENIRAFFLKRTVSRLIEMQSDYYLK 375
Cdd:pfam03969 314 LYDRDVKLVASAEVELSDLYLGGRLEFEFQRTLSRLLEMQSHDYLA 359
 
Name Accession Description Interval E-value
ZapE COG1485
Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, ...
18-376 7.90e-179

Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441094  Cd Length: 365  Bit Score: 500.78  E-value: 7.90e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  18 AGESLLVEYRWRVEQGLIDYDPAQVEALHYLQEMLDKLTA--ENRSGFLS---LSSARGKPCKSLYIYGGVGRGKSMLMD 92
Cdd:COG1485    1 MMMSPLERYQALLAAGGLQPDPAQEAAVARLDRLYDELLAyrPRKSGLLGrlfGRKRKPEPPKGLYLWGGVGRGKTMLMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  93 LFYDHCPIQEKRRVHFHTFILEVHEFSHRWRQEKkqDIIHSLAAEINASTKLLCFDEFHVIDVANAVILDRLFSRLFELG 172
Cdd:COG1485   81 LFFESLPVERKRRVHFHRFMQEVHARLHALRGQA--DPLPPVADRIAAEARLLCFDEFHVTDIADAMILGRLFEALFARG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 173 TVIVTTSNRHPDDLYQAGLVPELFLKFIELLKASADVVELVAKHDYRLTRIHGAEkTYFYPLDEHAASALEQCYRELTHS 252
Cdd:COG1485  159 VVLVATSNIPPDDLYKNGLQRARFLPFIALIKQHLDVLNLDSGTDYRLRRLEGAP-VYHTPLDAEADAALDAAFARLTGG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 253 APLKPYSLKVLGRNVVLRAAHGDVAFTTFDEVCRKPLGPADYLKIVQAFRVVIVSGIPRFGFDNHDEAKRFSTLVDALYF 332
Cdd:COG1485  238 APEEPETLEVNGREIPVPRAAGGVAWFDFADLCGGPRGQADYLELARRFHTVILSDVPVMGPDNRNEARRFITLIDELYD 317
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 503915558 333 HKVILICSAEAPARELYDENIRAFFLKRTVSRLIEMQSDYYLKQ 376
Cdd:COG1485  318 RRVKLIASAAAPPEELYTGGRGAFEFERTASRLIEMQSEEYLAL 361
ZapE NF040713
cell division protein ZapE;
26-369 3.07e-153

cell division protein ZapE;


Pssm-ID: 468677 [Multi-domain]  Cd Length: 344  Bit Score: 435.41  E-value: 3.07e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  26 YRWRVEQGLIDYDPAQVEALHYLQEMLDKLTA--ENRSGFLSLSSARGKPCKSLYIYGGVGRGKSMLMDLFYDHCPIQEK 103
Cdd:NF040713   2 YEAAVAFGGYRPDPAQAAAVERLDRLAEELAApaKKRGLLGRLFGRKKSPPRGLYLWGGVGRGKTMLMDLFYEALPIERK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 104 RRVHFHTFILEVHEFSHRWRQEKkqDIIHSLAAEINASTKLLCFDEFHVIDVANAVILDRLFSRLFELGTVIVTTSNRHP 183
Cdd:NF040713  82 RRVHFHEFMREVHQRLALLRGQA--DPLPPVADEIASEARLLCFDEFHVDDIADAMILGRLFEALFERGVVLVATSNTPP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 184 DDLYQAGLVPELFLKFIELLKASADVVELVAKHDYRLTRIHGAEkTYFYPLDEHAASALEQCYRELTHSAPLKPYSLKVL 263
Cdd:NF040713 160 DDLYKNGLNRERFLPAIALIKAHFDVVNVDGGTDYRLRRLEQAP-VYLTPLDAEADAALDAAFARLTGGAAAEPGTLEVN 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558 264 GRNVVLRAAHGDVAFTTFDEVCRKPLGPADYLKIVQAFRVVIVSGIPRFGFDNHDEAKRFSTLVDALYFHKVILICSAEA 343
Cdd:NF040713 239 GRELPVPRAAGGVAWFDFADLCEAPRSPSDYLALARRFHTVLLSGVPPLGDESRDAARRFIALIDELYDRKVKLIISAEV 318
                        330       340
                 ....*....|....*....|....*.
gi 503915558 344 PARELYDENIRAFFLKRTVSRLIEMQ 369
Cdd:NF040713 319 PLEELYTEGGLAFEFERTLSRLQEMQ 344
AFG1_ATPase pfam03969
AFG1-like ATPase; This P-loop motif-containing family of proteins includes AFG1, LACE1 and ...
21-375 2.23e-90

AFG1-like ATPase; This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE. ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family. LACE1, the mammalian homolog of AFG1, is a mitochondrial integral membrane protein that is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. It has also been demonstrated that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4 (cytochrome c oxidase 4), COX5A and COX6A, and is required for normal activity of complexes III and IV of the respiratory chain. ZapE is a cell division protein found in Gram-negative bacteria. The bacterial cell division process relies on the assembly, positioning, and constriction of FtsZ ring (the so-called Z-ring), a ring-like network that marks the future site of the septum of bacterial cell division. ZapE is a Z-ring associated protein required for cell division under low-oxygen conditions. It is an ATPase that appears at the constricting Z-ring late in cell division. It reduces the stability of FtsZ polymers in the presence of ATP in vitro.


Pssm-ID: 397872  Cd Length: 361  Bit Score: 275.92  E-value: 2.23e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558   21 SLLVEYRWRVEQGLIDYDPAQVEALHYLQEMLDKLTAenrSGFLSLSSARGK---------PCKSLYIYGGVGRGKSMLM 91
Cdd:pfam03969   2 TPPVRYIADLQRPDFFPDVAQANAVPHLDRLYQDLAA---QDFPRPARAGGKlwgrkpsvqPPRGLYLWGGVGRGKTWLM 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558   92 DLFYDHCPIQEKRRVHFHTFILEVHEFSHRWRQEKK--QDIIHSLAAEinasTKLLCFDEFHVIDVANAVILDRLFSRLF 169
Cdd:pfam03969  79 DLFFESLPGEKKRRTHFHRFMFRVHDELTTLQGGVDplAIIADRLAGE----ARLLCFDEFFVSDIGDAMLLGRLFEALF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  170 ELGTVIVTTSNRHPDDLYQAGLVPELFLKFIELLKASADVVELVAKHDYRLTRIHGAEkTYFYPLDEHAASALEQCYREL 249
Cdd:pfam03969 155 ARGVTLVATSNIAPEQLYKNGLQRARFLPAIDLLKSHCEVVNVDGGVDYRLRTLRQAE-LWLYPLDGYCWAAMDRLWDAL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  250 THSAPLKPYSLKVLGRNVVLRAAHGDVAFTTFDEVCRKPLGPADYLKIVQAFRVVIVSGIPRFGFDNHDEAKRFSTLVDA 329
Cdd:pfam03969 234 GLGEPEPLSTLEVNARALRARAVGGDLVWFSFACLCQAARSQNDYLALAERFHTVFLEDVPQMTRCSDDAARRFIALVDE 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 503915558  330 LYFHKVILICSAEAPARELYDENIRAFFLKRTVSRLIEMQSDYYLK 375
Cdd:pfam03969 314 LYDRDVKLVASAEVELSDLYLGGRLEFEFQRTLSRLLEMQSHDYLA 359
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
75-188 1.87e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 39.38  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503915558  75 KSLYIYGGVGRGKSML-----MDLfydhcpIQEKRRVHFHTfileVHEFSHRWRQEKKQdiiHSLAAEIN--ASTKLLCF 147
Cdd:COG1484  100 ENLILLGPPGTGKTHLaialgHEA------CRAGYRVRFTT----APDLVNELKEARAD---GRLERLLKrlAKVDLLIL 166
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 503915558 148 DEF--HVIDVANAVILDRLFSRLFELGTVIVtTSNRHPDDLYQ 188
Cdd:COG1484  167 DELgyLPLDAEGAELLFELISDRYERRSTII-TSNLPFSEWGE 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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