|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
374-1040 |
0e+00 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 624.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 374 PLETKLYLDLKKDALNVSVVFQYGEEKIFPNQTTQAQEQVLVRDFQAEQALLTRLKNSGFRLLNQSYWLFSEEKMYQFIY 453
Cdd:COG0553 19 ELLLLLRLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLALLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 454 DDLPELLEQTSVFMTDQVETLRAERDYFLDTRVEVNALTGMLDVQFNIDGITKQDVQNVLQALVEKKSYHRLQNGALIKL 533
Cdd:COG0553 99 LLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 534 TDASFQAFQSLADELYFKKKDLASTSIELSPAKGLQLEHALDDSQVDysetfkQLLQTLkqpdqfdDQVPETLNAQLRDY 613
Cdd:COG0553 179 GLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLR------RLREAL-------ESLPAGLKATLRPY 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 614 QVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSVKVVSGTk 693
Cdd:COG0553 246 QLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGT- 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 694 DERMTIIKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTPIENRLEEL 773
Cdd:COG0553 325 RERAKGANPFEDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEEL 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 774 WSIFQTISPGFLGPKKEFIQYPNDYI-----------RKITKPFILRRLKTDVLPDLPEKIEFEQYSELTKEQKQVYLAY 842
Cdd:COG0553 405 WSLLDFLNPGLLGSLKAFRERFARPIekgdeealerlRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAV 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 843 LERIEQQLDAVVDANQfnqeKIEILAGLTRLRQICCHPSLFLEN---YQGESGKLELLMTMIEQLRAENRRVLIFSQFSS 919
Cdd:COG0553 485 LEYLRRELEGAEGIRR----RGLILAALTRLRQICSHPALLLEEgaeLSGRSAKLEALLELLEELLAEGEKVLVFSQFTD 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 920 MLKIIEKELNKQRYQSFYLDGQTPLKDRVEMAEAFNNGER-EIFIISLKAGGTGLNLTGADTVILFDLWWNPAVEAQAAG 998
Cdd:COG0553 561 TLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEaPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAID 640
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 504822311 999 RAHRIGQTKKVEVIRLITQGTIEEKIFQLQERKRKLVDEIIQ 1040
Cdd:COG0553 641 RAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
606-812 |
8.87e-101 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 316.04 E-value: 8.87e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 606 LNAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLS 685
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 686 VKVVSGTKDERMtIIKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTP 765
Cdd:cd18012 81 VLVIHGTKRKRE-KLRALEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTP 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 504822311 766 IENRLEELWSIFQTISPGFLGPKKEF-------IQYPNDY-----IRKITKPFILRRLK 812
Cdd:cd18012 160 IENHLGELWSIFDFLNPGLLGSYKRFkkrfakpIEKDGDEealeeLKKLISPFILRRLK 218
|
|
| SNF2_assoc |
pfam08455 |
Bacterial SNF2 helicase associated; This domain is found in bacterial proteins of the SWF/SNF ... |
232-603 |
2.11e-85 |
|
Bacterial SNF2 helicase associated; This domain is found in bacterial proteins of the SWF/SNF/SWI helicase family to the N-terminus of the SNF2 family N-terminal domain (pfam00176) and together with the Helicase conserved C-terminal domain (pfam00271). The function of the domain is not clear.
Pssm-ID: 462483 Cd Length: 370 Bit Score: 280.65 E-value: 2.11e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 232 VNLPPFLILDFFENLISRSFEIIRDDDSIIDQLNIEQNLPKIKFPITLNEDGSFIVNFQSLFsYQFSSYYQFLNKDHEFY 311
Cdd:pfam08455 1 LVLPPSLLDEFLELLKGRKFYLELDEGEELKEVKIVEENPPLSFSLKKEKDDGIILTLNKDP-ILLGEDYLYFLYDGTIY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 312 FLSTEQKKIIEQIYTILPYQKKYSYQISKAKMTHFIGYVLPQLESIGEVQYSEEAETQIKQVPLETKLYLDLKKDALNVS 391
Cdd:pfam08455 80 RLSKEQCKLLSPLLKLLNLLGTKEITISKEDLPKFLSEVLPKLKKIGEVEIPEELLEKYVPEPLKAKFYLDRDDDRITAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 392 VVFQYGEEKIFPNQTTqaqeqVLVRDFQAEQALLTRLKNSGFRLLNQSYWLFSEEKMYQFIYDDLPELLEQTSVFMTDQV 471
Cdd:pfam08455 160 VKFQYGDIEFNPLEDL-----ILVRDVEKEAKILNLLEQYGFKVDDGKFYLDDEEKIYDFLTEGLPKLQELGEVYYSDAF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 472 ETLRAERDYFLDTRVEVNALTGMLDVQFNIDGITKQDVQNVLQALVEKKSYHRLQNGALIKLTDASFQAFQSLADELYFK 551
Cdd:pfam08455 235 KNLKVKPSPSVSVGVSVDEEGNLLEISFDIDGIDEEELANILQALREKKKYYRLKDGSFLDLEEEELKELSELLDELGLS 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 504822311 552 KKDLASTSIELSPAKGLQLEHALDDS----QVDYSETFKQLLQTLKQPDQFDDQVP 603
Cdd:pfam08455 315 KKDLENGTIKLPKYRALYLDELLEENeligSIKRDKEFKQLVEDLKNPEDSDFEVP 370
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
603-1060 |
9.72e-83 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 290.93 E-value: 9.72e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 603 PETLNAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFA 681
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGItGPHMVVAPKSTLGNWMNEIRRFC 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 682 PTLSVKVVSGTKDERMTIIKDNHEP---DVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQR 758
Cdd:PLN03142 243 PVLRAVKFHGNPEERAHQREELLVAgkfDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 759 FALSGTPIENRLEELWSIFQTISPGFLGPKKEF-----IQYPND------YIRKITKPFILRRLKTDVLPDLPEKIEFEQ 827
Cdd:PLN03142 323 LLITGTPLQNNLHELWALLNFLLPEIFSSAETFdewfqISGENDqqevvqQLHKVLRPFLLRRLKSDVEKGLPPKKETIL 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 828 YSELTKEQKQVYLAYLERieqQLDAVvdanQFNQEKIEILAGLTRLRQICCHPSLF---------------LENyqgeSG 892
Cdd:PLN03142 403 KVGMSQMQKQYYKALLQK---DLDVV----NAGGERKRLLNIAMQLRKCCNHPYLFqgaepgppyttgehlVEN----SG 471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 893 KLELLMTMIEQLRAENRRVLIFSQFSSMLKIIEKELNKQRYQSFYLDGQTPLKDRVEMAEAFN--NGEREIFIISLKAGG 970
Cdd:PLN03142 472 KMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNkpGSEKFVFLLSTRAGG 551
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 971 TGLNLTGADTVILFDLWWNPAVEAQAAGRAHRIGQTKKVEVIRLITQGTIEEKIFQLQERKRKLVDEIIQPGE-TLLSSL 1049
Cdd:PLN03142 552 LGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRlAEQKTV 631
|
490
....*....|.
gi 504822311 1050 NEKELRELLTF 1060
Cdd:PLN03142 632 NKDELLQMVRY 642
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
613-883 |
3.12e-63 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 216.40 E-value: 3.12e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 613 YQVTGFKWFkaLARYQ---LGGILADEMGLGKTIQAISFI--LSEKTTEKIGPSIVIAPASLIYNWKKEFEKFA--PTLS 685
Cdd:pfam00176 1 YQIEGVNWM--LSLENnlgRGGILADEMGLGKTLQTISLLlyLKHVDKNWGGPTLIVVPLSLLHNWMNEFERWVspPALR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 686 VKVVSGTKDERMTIIKDNHEP---DVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALS 762
Cdd:pfam00176 79 VVVLHGNKRPQERWKNDPNFLadfDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 763 GTPIENRLEELWSIFQTISPGFLGPKKEF-------IQYPNDY-----IRKITKPFILRRLKTDVLPDLPEKIEFEQYSE 830
Cdd:pfam00176 159 GTPLQNNLEELWALLNFLRPGPFGSLSTFrnwfdrpIERGGGKkgvsrLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCR 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 504822311 831 LTKEQKQVYLAYLERIEqqLDAVVDANQFNQEKIEILAGLTRLRQICCHPSLF 883
Cdd:pfam00176 239 LSKLQRKLYQTFLLKKD--LNAIKTGEGGREIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
610-810 |
1.36e-61 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 207.80 E-value: 1.36e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEK-IGPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKeRGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERMTIIKDNHEP--DVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTPI 766
Cdd:cd17919 81 YHGSQRERAQIRAKEKLDkfDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 504822311 767 ENRLEELWSIFQtispgFLGPkkefiqypndyirkitkPFILRR 810
Cdd:cd17919 161 QNNLEELWALLD-----FLDP-----------------PFLLRR 182
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
891-1015 |
9.47e-57 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 191.92 E-value: 9.47e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 891 SGKLELLMTMIEQLRAENRRVLIFSQFSSMLKIIEKELNKQRYQSFYLDGQTPLKDRVEMAEAFNNGERE-IFIISLKAG 969
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 504822311 970 GTGLNLTGADTVILFDLWWNPAVEAQAAGRAHRIGQTKKVEVIRLI 1015
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
610-810 |
6.60e-53 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 184.86 E-value: 6.60e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFI------LSEKTTEKIGPSIVIAPASLIYNWKKEFEKFAPT 683
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILasdhhkRANSFNSENLPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 684 LSVKVV--SGTKDERMTIIKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFAL 761
Cdd:cd17999 81 AFLKPLayVGPPQERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLIL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504822311 762 SGTPIENRLEELWSIFQTISPGFLGPKKEFIQypnDYIRKITK--------------------------PFILRR 810
Cdd:cd17999 161 SGTPIQNNVLELWSLFDFLMPGYLGTEKQFQR---RFLKPILAsrdskasakeqeagalalealhkqvlPFLLRR 232
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
607-812 |
2.44e-49 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 174.43 E-value: 2.44e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 607 NAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFAPTLS 685
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNInGPHLIIVPKSTLDNWMREFKRWCPSLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 686 VKVVSGTKDERMTIIKDNHEP---DVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALS 762
Cdd:cd17997 81 VVVLIGDKEERADIIRDVLLPgkfDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLT 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504822311 763 GTPIENRLEELWSIFQTISPGFLGPKKEFIQYPN------------DYIRKITKPFILRRLK 812
Cdd:cd17997 161 GTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNvnncdddnqevvQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
610-810 |
6.62e-47 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 167.93 E-value: 6.62e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSVKVV 689
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 690 SGT-KDERMTI---IKDNHepDVWITSYPLLR---QDVKLYKHMYF--DVMILDEAQAIKNHLTQTAKATRQIQAKQRFA 760
Cdd:cd18001 81 HGTsKKERERNlerIQRGG--GVLLTTYGMVLsntEQLSADDHDEFkwDYVILDEGHKIKNSKTKSAKSLREIPAKNRII 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504822311 761 LSGTPIENRLEELWSIFQTISPG-FLGPKKEFIQYPNDYI-----------------------RKITKPFILRR 810
Cdd:cd18001 159 LTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPItrgrdkdatqgekalgsevaenlRQIIKPYFLRR 232
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
610-810 |
9.77e-46 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 164.06 E-value: 9.77e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNwGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERMTIIKDNHEPDVW---ITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTP 765
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNSFhvcITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504822311 766 IENRLEELWSIFQTISPGFLGPKKEFIQYPNDYIR------------------KITKPFILRR 810
Cdd:cd18003 161 LQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTamsegsqeeneelvrrlhKVLRPFLLRR 223
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
607-812 |
6.64e-44 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 159.47 E-value: 6.64e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 607 NAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSV 686
Cdd:cd18009 1 GGVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 687 KVVSGTKDERMTIIKDNHEPD-------VWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRF 759
Cdd:cd18009 81 LLYHGTKEERERLRKKIMKREgtlqdfpVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504822311 760 ALSGTPIENRLEELWSIFQTISP-------------GFLGPKK----------EFIQYPNDYIRKITKPFILRRLK 812
Cdd:cd18009 161 LLTGTPLQNNLSELWSLLNFLLPdvfddlssfeswfDFSSLSDnaadisnlseEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
610-810 |
3.02e-43 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 155.94 E-value: 3.02e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEK-IGPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLgLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 ----VSGTKDER---------MTIIKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQA 755
Cdd:cd18000 81 lhssGSGTGSEEklgsierksQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRT 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 504822311 756 KQRFALSGTPIENRLEELWSIFqtispgflgpkkEFIqYPndyirkitkPFILRR 810
Cdd:cd18000 161 PHRLILSGTPIQNNLKELWSLF------------DFV-FP---------PYLLRR 193
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
610-810 |
2.33e-42 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 155.14 E-value: 2.33e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWfkALARyqlGGILADEMGLGKTIQAISFILS------------------EKTTEKIGPSIVIAPASLIY 671
Cdd:cd18008 1 LLPYQKQGLAW--MLPR---GGILADEMGLGKTIQALALILAtrpqdpkipeeleenssdPKKLYLSKTTLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 672 NWKKEFEKF--APTLSVKVVSGtkDERMTIIKDNHEPDVWITSYPLLRQDVK-----------------LYKHMYFDVmI 732
Cdd:cd18008 76 QWKDEIEKHtkPGSLKVYVYHG--SKRIKSIEELSDYDIVITTYGTLASEFPknkkgggrdskekeaspLHRIRWYRV-I 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 733 LDEAQAIKNHLTQTAKATRQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQY-----------PNDYIRK 801
Cdd:cd18008 153 LDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDiskpfskndrkALERLQA 232
|
....*....
gi 504822311 802 ITKPFILRR 810
Cdd:cd18008 233 LLKPILLRR 241
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
610-810 |
3.75e-42 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 152.54 E-value: 3.75e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSVKVV 689
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 690 SGTKDERMTI---IKDNHEP-DVWITSYPLL---RQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALS 762
Cdd:cd17998 81 YGSQEERKHLrydILKGLEDfDVIVTTYNLAtsnPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 504822311 763 GTPIENRLEELWSIFQTISPgflgpkkefiqypndyirkitKPFILRR 810
Cdd:cd17998 161 GTPLQNNLLELMSLLNFIMP---------------------KPFILRR 187
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
597-822 |
8.22e-42 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 153.67 E-value: 8.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 597 QFDDQVPETLNAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKK 675
Cdd:cd18064 3 RFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIpGPHMVLVPKSTLHNWMA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 676 EFEKFAPTLSVKVVSGTKDERMTIIKDNHEP---DVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQ 752
Cdd:cd18064 83 EFKRWVPTLRAVCLIGDKDQRAAFVRDVLLPgewDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVRE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 753 IQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPN-----------DYIRKITKPFILRRLKTDVLPDLPE 821
Cdd:cd18064 163 FKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDtnnclgdqklvERLHMVLRPFLLRRIKADVEKSLPP 242
|
.
gi 504822311 822 K 822
Cdd:cd18064 243 K 243
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
610-791 |
4.70e-41 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 151.38 E-value: 4.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISF---ILSEKTTEKI------------------GPSIVIAPAS 668
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFlaaVLGKTGTRRDrennrprfkkkppassakKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 669 LIYNWKKEFEKFAPTLSVKVVSGTKDERMTIIKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAK 748
Cdd:cd18005 81 VLYNWKDELDTWGHFEVGVYHGSRKDDELEGRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLTQ 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 504822311 749 ATRQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEF 791
Cdd:cd18005 161 AMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQF 203
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
610-810 |
6.95e-41 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 150.35 E-value: 6.95e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIwGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERMTIIK---------DNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRF 759
Cdd:cd18002 81 YWGNPKDRKVLRKfwdrknlytRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504822311 760 ALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPNDYIRK------------------ITKPFILRR 810
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIEShaenktglnehqlkrlhmILKPFMLRR 229
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
607-812 |
4.85e-39 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 145.20 E-value: 4.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 607 NAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFI--LSEKTTEKiGPSIVIAPASLIYNWKKEFEKFAPTL 684
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLItyLMEKKKNN-GPYLVIVPLSTLSNWVSEFEKWAPSV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 685 SVKVVSGTKDERMTIIKD--NHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNH---LTQTAKatRQIQAKQRF 759
Cdd:cd17996 80 SKIVYKGTPDVRKKLQSQirAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAqskLTQTLN--TYYHARYRL 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504822311 760 ALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPND--------------------YIR---KITKPFILRRLK 812
Cdd:cd17996 158 LLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTpfantgeqvkielneeetllIIRrlhKVLRPFLLRRLK 233
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
610-812 |
6.48e-38 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 142.08 E-value: 6.48e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIpGPHMVLVPKSTLHNWMNEFKRWVPSLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERMTIIKDNHEP---DVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTP 765
Cdd:cd18065 96 LIGDKDARAAFIRDVMMPgewDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTP 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 504822311 766 IENRLEELWSIFQTISPGFLGPKKEFIQYPN-----------DYIRKITKPFILRRLK 812
Cdd:cd18065 176 LQNNLHELWALLNFLLPDVFNSADDFDSWFDtknclgdqklvERLHAVLKPFLLRRIK 233
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
610-810 |
2.79e-37 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 140.50 E-value: 2.79e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKW-FKALARYQLGG----ILADEMGLGKTIQAISFI--------LSEKTTEKIgpsIVIAPASLIYNWKKE 676
Cdd:cd18004 1 LRPHQREGVQFlYDCLTGRRGYGgggaILADEMGLGKTLQAIALVwtllkqgpYGKPTAKKA---LIVCPSSLVGNWKAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 677 FEKFAPTLSVKVV---SGTKDERMTIIKDNHEP--DVWITSYPLLRQDVKLYKH-MYFDVMILDEAQAIKNHLTQTAKAT 750
Cdd:cd18004 78 FDKWLGLRRIKVVtadGNAKDVKASLDFFSSAStyPVLIISYETLRRHAEKLSKkISIDLLICDEGHRLKNSESKTTKAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 751 RQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEF-------IQYPND----------------YIRKITKPFI 807
Cdd:cd18004 158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFrkvfeepILRSRDpdaseedkelgaersqELSELTSRFI 237
|
...
gi 504822311 808 LRR 810
Cdd:cd18004 238 LRR 240
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
610-810 |
6.04e-37 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 138.72 E-value: 6.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLlGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERMTI---IKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTP 765
Cdd:cd18006 81 YMGDKEKRLDLqqdIKSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 504822311 766 IENRLEELWSIFQTISPGFLGPKK--EFIQYPNDY---------IRKITKPFILRR 810
Cdd:cd18006 161 IQNSLQELYALLSFIEPNVFPKDKldDFIKAYSETddesetveeLHLLLQPFLLRR 216
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
630-802 |
5.62e-35 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 133.57 E-value: 5.62e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 630 GGILADEMGLGKTIQAISFILS-------EKTTekigpsIVIAPASLIYNWKKEFEKFAP-------TLSVKVVSGTKDE 695
Cdd:cd18007 28 GCILAHTMGLGKTLQVITFLHTylaaaprRSRP------LVLCPASTLYNWEDEFKKWLPpdlrpllVLVSLSASKRADA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 696 RMTIIKDNH-EPDVWITSYPLLR------QDVKLYKHMYF--------DVMILDEAQAIKNHLTQTAKATRQIQAKQRFA 760
Cdd:cd18007 102 RLRKINKWHkEGGVLLIGYELFRnlasnaTTDPRLKQEFIaalldpgpDLLVLDEGHRLKNEKSQLSKALSKVKTKRRIL 181
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 504822311 761 LSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYpndYIRKI 802
Cdd:cd18007 182 LTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKK---FVKPI 220
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
609-810 |
2.84e-34 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 130.94 E-value: 2.84e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 609 QLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILS-EKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSVK 687
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYlFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 688 VVSGTKDERMTI------------IKDNhepdVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQA 755
Cdd:cd17993 81 VYLGDIKSRDTIreyefyfsqtkkLKFN----VLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKT 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504822311 756 KQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPN----DYIRKITK---PFILRR 810
Cdd:cd17993 157 NNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDeeqeKGIADLHKelePFILRR 218
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
610-810 |
6.51e-34 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 130.06 E-value: 6.51e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFApTLSVKV 688
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIrGPFLVIAPLSTIPNWQREFETWT-DMNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERMTI--------------IKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQ 754
Cdd:cd17995 80 YHGSGESRQIIqqyemyfkdaqgrkKKGVYKFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504822311 755 AKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQypnDY-----------IRKITKPFILRR 810
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLE---EFgdlktaeqvekLQALLKPYMLRR 223
|
|
| SWIM |
COG4715 |
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown]; |
1-525 |
1.39e-32 |
|
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
Pssm-ID: 443750 [Multi-domain] Cd Length: 508 Bit Score: 133.41 E-value: 1.39e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 1 MAQFYLDTQDILKITGQRFFRRGVDLYKKGRVTKLtyNQMINSWQATVKGGNLYQVSIFFFEDDDLEAKCDCSAYQTHYt 80
Cdd:COG4715 1 MARLELTEDDIRRLAGPRIFERGREYAREGRVLDL--DVEDGRLEATVQGSEDYRVRVDLDDGGDLDSSCTCPYGGGGF- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 81 CKHIAAVLLAITKHnssttffPEQNTTEVTDPFPLRmiDMFETeqtglITKETQLKLHYQLEEkRHRVLKDTYYELQLKV 160
Cdd:COG4715 78 CKHVVAVLLALLDQ-------PEEGAPRQSEREALE--ELLER-----LSKEELVELLLELAA-EDPELRELRRALDDSG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 161 GENQLYIVKELPAFIKAIKFNEVHKITETFSYKPKDHYFDAIDLALLDMIGEAITHEELYSPDFPTVDKRSVNLPPFLIL 240
Cdd:COG4715 143 GDYLREELLELSRLAALSLTATLAALAPRSTLALRLALLRLLLLLLAPSSLDGAPPGLSLALVRELLPALAERALALLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 241 DFFENLISRSFEIIRDDDSIIDQLNIEQNLPKIKFPITLNEDGSFIVNFQSLFSYQFSSYYQFLNKDHEFYFLSTEQKKI 320
Cdd:COG4715 223 VPAPAGLLKLRLLLARPGALLLSLLDLLLRLDLLLGLLLLALLLLLLLLLQLLALLLLALRTLAALLLLLRLRLRLGLAA 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 321 IEQIYTILPYQKKYSYQISKAKMTHFIGYVLPQLESIGEVQYSEEAETQIKQVPLETKLYLDLKKDALNVSVVFQYGEEK 400
Cdd:COG4715 303 GLALAVLLLLLLLLLPLPLALLALSLLLRLLLALLRLALLVLLYLLLILLLLALLLLALLLLLELLLLLALLLLLAEVEL 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 401 IFPNQTTQAQEQVLVRDFQAEQALLTRLKNSGFRLLNQSYWLFSEEKMYQFIYDDLPELLEQTSVFMTDQVETLRAERDY 480
Cdd:COG4715 383 ARLLEEALLIRRRLLLLLLLLLRLLDLLALLALRLLLLLLLAVLSEAEDLLLELLETLGLHRLLLLEAREELLPELAADL 462
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 504822311 481 FLDTRVEVNALTGMLDVQFNIDGITKQDVQNVLQALVEKKSYHRL 525
Cdd:COG4715 463 ALLLLLEALDLLALEALALLLLLELLLLLAVTLLLLAIDELLLLA 507
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
610-794 |
8.29e-32 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 123.85 E-value: 8.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWfkALARyqlGG--ILADEMGLGKTIQAISFILSEKtteKIGPSIVIAPASLIYNWKKEFEKFAPTLSVK 687
Cdd:cd18010 1 LLPFQREGVCF--ALRR---GGrvLIADEMGLGKTVQAIAIAAYYR---EEWPLLIVCPSSLRLTWADEIERWLPSLPPD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 688 ---VVSGTKDERMTiikdnHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQI--QAKQRFALS 762
Cdd:cd18010 73 diqVIVKSKDGLRD-----GDAKVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLS 147
|
170 180 190
....*....|....*....|....*....|..
gi 504822311 763 GTPIENRLEELWSIFQTISPGFLGPKKEFIQY 794
Cdd:cd18010 148 GTPALSRPIELFTQLDALDPKLFGRFHDFGRR 179
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
596-812 |
7.71e-30 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 119.38 E-value: 7.71e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 596 DQFDDQVPETLNAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWK 674
Cdd:cd18062 10 EKVEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRInGPFLIIVPLSTLSNWV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 675 KEFEKFAPTLSVKVVSGTKDERMTIIKD--NHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNH---LTQTAKA 749
Cdd:cd18062 90 YEFDKWAPSVVKVSYKGSPAARRAFVPQlrSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHhckLTQVLNT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 750 trQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPN---------------------DYIRKITKPFIL 808
Cdd:cd18062 170 --HYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNapfamtgekvdlneeetiliiRRLHKVLRPFLL 247
|
....
gi 504822311 809 RRLK 812
Cdd:cd18062 248 RRLK 251
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
596-812 |
1.13e-29 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 119.01 E-value: 1.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 596 DQFDDQVPETLNAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWK 674
Cdd:cd18063 10 ERVEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLnGPYLIIVPLSTLSNWT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 675 KEFEKFAPTLSVKVVSGTKDERMTIIKD--NHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNH---LTQTAKA 749
Cdd:cd18063 90 YEFDKWAPSVVKISYKGTPAMRRSLVPQlrSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHhckLTQVLNT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 750 trQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPN---------------------DYIRKITKPFIL 808
Cdd:cd18063 170 --HYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNapfamtgervdlneeetiliiRRLHKVLRPFLL 247
|
....
gi 504822311 809 RRLK 812
Cdd:cd18063 248 RRLK 251
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
593-810 |
1.25e-29 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 118.18 E-value: 1.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 593 KQPDQFDDQvpetlNAQLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIY 671
Cdd:cd18054 9 KQPSYIGGE-----NLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLyGPFLLVVPLSTLT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 672 NWKKEFEKFAPTLSVKVVSGTKDERMTI------------IKDNhepdVWITSYPLLRQDVKLYKHMYFDVMILDEAQAI 739
Cdd:cd18054 84 SWQREFEIWAPEINVVVYIGDLMSRNTIreyewihsqtkrLKFN----ALITTYEILLKDKTVLGSINWAFLGVDEAHRL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504822311 740 KNHLTQTAKATRQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQ-----YPNDY--IRKITKPFILRR 810
Cdd:cd18054 160 KNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEdhgkgRENGYqsLHKVLEPFLLRR 237
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
630-810 |
3.64e-28 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 114.11 E-value: 3.64e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 630 GGILADEMGLGKTIQAISFILSEKTTEKI-----------------------GPSIVIAPASLIYNWKKEFEKFAPTLSV 686
Cdd:cd18072 22 GGILADDMGLGKTLTMIALILAQKNTQNRkeeekekalteweskkdstlvpsAGTLVVCPASLVHQWKNEVESRVASNKL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 687 KVVSGTKDERMTIIKDNHEPDVWITSYPLLRQDVKLYKH---------MYFDVMILDEAQAIKNHLTQTAKATRQIQAKQ 757
Cdd:cd18072 102 RVCLYHGPNRERIGEVLRDYDIVITTYSLVAKEIPTYKEesrssplfrIAWARIILDEAHNIKNPKVQASIAVCKLRAHA 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504822311 758 RFALSGTPIENRLEELWSIFQtispgFL--GPKKEFIQYPNDYIRK----------ITKPFILRR 810
Cdd:cd18072 182 RWALTGTPIQNNLLDMYSLLK-----FLrcSPFDDLKVWKKQVDNKsrkggerlniLTKSLLLRR 241
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
892-1004 |
4.82e-28 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 109.22 E-value: 4.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 892 GKLELLMTMIEqlRAENRRVLIFSQFSSMLKIiEKELNKQRYQSFYLDGQTPLKDRVEMAEAFNNGEReIFIISLKAGGT 971
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKI-DVLVATDVAER 76
|
90 100 110
....*....|....*....|....*....|...
gi 504822311 972 GLNLTGADTVILFDLWWNPAVEAQAAGRAHRIG 1004
Cdd:pfam00271 77 GLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
630-833 |
2.81e-27 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 111.48 E-value: 2.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 630 GGILADEMGLGKTIQAISFILsekTTEKIGP---------SIVIAPASLIYNWKKEFEKFAPTLSVKVVSGTKDERMTII 700
Cdd:cd18066 26 GAILADEMGLGKTLQCISLIW---TLLRQGPyggkpvikrALIVTPGSLVKNWKKEFQKWLGSERIKVFTVDQDHKVEEF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 701 KDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTPIENRLEELWSIFQTI 780
Cdd:cd18066 103 IASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFV 182
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 504822311 781 SPGFLGPKKEFiqypndyiRKITKPFILRRLKTDVLPDlPEKIEFEQYSELTK 833
Cdd:cd18066 183 NPGILGSLSTY--------RKVYEEPIVRSREPTATPE-EKKLGEARAAELTR 226
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
610-782 |
1.72e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 104.83 E-value: 1.72e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILS-EKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSVkv 688
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSlYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYV-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 vsgtkderMTIIKDNhepdVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTPIEN 768
Cdd:cd17994 79 --------VTYVGDH----VLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQN 146
|
170
....*....|....
gi 504822311 769 RLEELWSIFQTISP 782
Cdd:cd17994 147 NLEELFHLLNFLTP 160
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
629-777 |
2.11e-25 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 106.01 E-value: 2.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 629 LGGILADEMGLGKTIQAISFILSEKTtekigpsIVIAPASLIYNWKKEFEKFAPTLSVKVVSGTKDERMTIIKDNHEPDV 708
Cdd:cd18071 49 RGGILADDMGLGKTLTTISLILANFT-------LIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNRDPKLLSKYDI 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504822311 709 WITSYPLLRQDVKL-----YKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTPIENRLEELWSIF 777
Cdd:cd18071 122 VLTTYNTLASDFGAkgdspLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLL 195
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
610-810 |
7.11e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 103.98 E-value: 7.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKFApTLSVKVV 689
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 690 SGT--------------KDERMTIIKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQA 755
Cdd:cd18060 80 HGSlasrqmiqqyemycKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504822311 756 KQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPNDY--------IRKITKPFILRR 810
Cdd:cd18060 160 EHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLkteeqvqkLQAILKPMMLRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
610-810 |
1.40e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 103.19 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKFApTLSVKVV 689
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 690 SGTKDERMTI--------------IKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQA 755
Cdd:cd18059 80 HGSQASRRTIqlyemyfkdpqgrvIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504822311 756 KQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPNDY--------IRKITKPFILRR 810
Cdd:cd18059 160 EHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLkteeqvqkLQAILKPMMLRR 222
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
610-792 |
2.04e-24 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 102.97 E-value: 2.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWF-----KALARYQ----LGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKF 680
Cdd:cd18069 1 LKPHQIGGIRFLydniiESLERYKgssgFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 681 APTLS---------VKV-----VSGTKDERMTIIKD-NHEPDVWITSYPLLRQDVKLykhmyfDVMILDEAQAIKNHLTQ 745
Cdd:cd18069 81 LPPPEalpnvrprpFKVfilndEHKTTAARAKVIEDwVKDGGVLLMGYEMFRLRPGP------DVVICDEGHRIKNCHAS 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 504822311 746 TAKATRQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFI 792
Cdd:cd18069 155 TSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFS 201
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
610-804 |
4.00e-24 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 102.66 E-value: 4.00e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTG--FKW---FKALARYQ----LGGILADEMGLGKTIQAISF---ILSEKTTEKIGPSIVIAPASLIYNWKKEF 677
Cdd:cd18068 1 LKPHQVDGvqFMWdccCESLKKTKkspgSGCILAHCMGLGKTLQVVTFlhtVLLCEKLENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 678 EKF------APTLSVKVVSGTKDERMTIIKDNH---EPDVWITSYPLLR-----QDVKLYKHMYFDVM-----------I 732
Cdd:cd18068 81 EKWqeglkdEEKIEVNELATYKRPQERSYKLQRwqeEGGVMIIGYDMYRilaqeRNVKSREKLKEIFNkalvdpgpdfvV 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504822311 733 LDEAQAIKNHLTQTAKATRQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIqypNDYIRKITK 804
Cdd:cd18068 161 CDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFR---NRFVNPIQN 229
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
610-810 |
6.62e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 101.27 E-value: 6.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFiLSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFApTLSVKV 688
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITF-LSEIFLMGIrGPFLIIAPLSTITNWEREFRTWT-EMNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGT--------------KDERMTIIKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQ 754
Cdd:cd18058 79 YHGSqisrqmiqqyemyyRDEQGNPLSGIFKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMA 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504822311 755 AKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPNDY--------IRKITKPFILRR 810
Cdd:cd18058 159 LEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLkteeqvkkLQSILKPMMLRR 222
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
922-1004 |
1.52e-23 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 95.36 E-value: 1.52e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 922 KIIEKELNKQRYQSFYLDGQTPLKDRVEMAEAFNNGEReIFIISLKAGGTGLNLTGADTVILFDLWWNPAVEAQAAGRAH 1001
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI-KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79
|
...
gi 504822311 1002 RIG 1004
Cdd:smart00490 80 RAG 82
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
610-791 |
3.29e-23 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 99.85 E-value: 3.29e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKW-FKALARYQLGG----ILADEMGLGKTIQAISFIL-----SEKTTEKIGPSIVIAPASLIYNWKKEFEK 679
Cdd:cd18067 1 LRPHQREGVKFlYRCVTGRRIRGshgcIMADEMGLGKTLQCITLMWtllrqSPQCKPEIDKAIVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 680 F--APTLSVKVVSGTKDE--RMTIIKDNHE-----PDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKAT 750
Cdd:cd18067 81 WlgGRLQPLAIDGGSKKEidRKLVQWASQQgrrvsTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 504822311 751 RQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEF 791
Cdd:cd18067 161 DSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEF 201
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
610-810 |
4.08e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 99.37 E-value: 4.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILS-EKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSlYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERmTIIKDNH-----------------------EPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQ 745
Cdd:cd18056 81 YVGDKDSR-AIIRENEfsfednairggkkasrmkkeasvKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSK 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504822311 746 TAKATRQIQAKQRFALSGTPIENRLEELWSIFQTISP-------GFLgpkKEFIQYPN-DYIRKITK---PFILRR 810
Cdd:cd18056 160 FFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPerfhnleGFL---EEFADIAKeDQIKKLHDmlgPHMLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
610-810 |
4.94e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 98.93 E-value: 4.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILS-EKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSlYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERmTIIKDNH-----------------------EPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQ 745
Cdd:cd18055 81 YTGDKDSR-AIIRENEfsfddnavkggkkafkmkreaqvKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSK 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504822311 746 TAKATRQIQAKQRFALSGTPIENRLEELWSIFQTISP-------GFLgpkKEFIQYPN-DYIRKITK---PFILRR 810
Cdd:cd18055 160 FFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPerfnnleGFL---EEFADISKeDQIKKLHDllgPHMLRR 232
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
602-789 |
1.19e-22 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 96.79 E-value: 1.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 602 VPETLNAQLRDYQVTGFKWFKALARyqlGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAP-ASLIYNWKKEFEKF 680
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 681 APTLSVKVVSGTKDERMTIIKD---NHEPDVWITSYPLLRQDVKLYKHMY--FDVMILDEAQAIKN--HLTQTAKATRQI 753
Cdd:smart00487 78 GPSLGLKVVGLYGGDSKREQLRkleSGKTDILVTTPGRLLDLLENDKLSLsnVDLVILDEAHRLLDggFGDQLEKLLKLL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 504822311 754 -QAKQRFALSGTP---IENRLEELWSIFQTISPGFLGPKK 789
Cdd:smart00487 158 pKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEP 197
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
609-810 |
1.73e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 97.43 E-value: 1.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 609 QLRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKI-GPSIVIAPASLIYNWKKEFEKFAPTLSVK 687
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLyGPFLLVVPLSTLTSWQREIQTWAPQMNAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 688 VVSGTKDERMTIikDNHE----------PDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQ 757
Cdd:cd18053 100 VYLGDINSRNMI--RTHEwmhpqtkrlkFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNH 177
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 758 RFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQ-------YPNDYIRKITKPFILRR 810
Cdd:cd18053 178 RLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEehgkgreYGYASLHKELEPFLLRR 237
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
610-810 |
2.81e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 96.67 E-value: 2.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILS-EKTTEKIGPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSlYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERmTIIKDNH-----------------------EPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQ 745
Cdd:cd18057 81 YTGDKESR-SVIRENEfsfednairsgkkvfrmkkeaqiKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSK 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504822311 746 TAKATRQIQAKQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQ-----YPNDYIRKITK---PFILRR 810
Cdd:cd18057 160 FFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEefadiSKEDQIKKLHDllgPHMLRR 232
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
610-809 |
3.07e-22 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 97.41 E-value: 3.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALaryqlGGILADEMGLGKTIQAISFIL--------------------------SEKTTEKIGPSIV 663
Cdd:cd18070 1 LLPYQRRAVNWMLVP-----GGILADEMGLGKTVEVLALILlhprpdndldaadddsdemvccpdclVAETPVSSKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 664 IAPASLIYNWKKEFEKFAPT-LSVKVVSGTKDERMTIIKDNH---EPDVWITSYPLLRQDV------------KLYK--- 724
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPSsLKVLTYQGVKKDGALASPAPEilaEYDIVVTTYDVLRTELhyaeanrsnrrrRRQKrye 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 725 -------HMYFDVMILDEAQAIKNHLTQTAKATRQIQAKQRFALSGTPIENRLEELWSIFQtispgFLGP--------KK 789
Cdd:cd18070 156 appsplvLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLS-----FLGVepfcdsdwWA 230
|
250 260
....*....|....*....|....*.
gi 504822311 790 EFIQYPN------DYIRKITKPFILR 809
Cdd:cd18070 231 RVLIRPQgrnkarEPLAALLKELLWR 256
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
610-810 |
2.49e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 93.92 E-value: 2.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYNWKKEFEKFApTLSVKVV 689
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 690 SGT--------------KDERMTIIKDNHEPDVWITSYPLLRQDVKLYKHMYFDVMILDEAQAIKNHLTQTAKATRQIQA 755
Cdd:cd18061 80 HGSlisrqmiqqyemyfRDSQGRIIRGAYRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504822311 756 KQRFALSGTPIENRLEELWSIFQTISPGFLGPKKEFIQYPNDY--------IRKITKPFILRR 810
Cdd:cd18061 160 EHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLkteeqvqkLQAILKPMMLRR 222
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
609-1012 |
2.27e-18 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 90.08 E-value: 2.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 609 QLRDYQVTGF-KWFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIgpsIVIAP-ASLIYNWKKEFEKFaptLSV 686
Cdd:COG1061 80 ELRPYQQEALeALLAALERGGGRGLVVAPTGTGKTVLALALAAELLRGKRV---LVLVPrRELLEQWAEELRRF---LGD 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 687 KVVSGTKDERmtiikdnhEPDVWITSYPLLRQDVKLYKHM-YFDVMILDEAqaiknHLTqTAKATRQI----QAKQRFAL 761
Cdd:COG1061 154 PLAGGGKKDS--------DAPITVATYQSLARRAHLDELGdRFGLVIIDEA-----HHA-GAPSYRRIleafPAAYRLGL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 762 SGTPI-ENRLEELWSIFQTISPGFlgPKKEFIQypndyiRKITKPFILrrlktdvlpdlpekieFEQYSELTKEQKQvYL 840
Cdd:COG1061 220 TATPFrSDGREILLFLFDGIVYEY--SLKEAIE------DGYLAPPEY----------------YGIRVDLTDERAE-YD 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 841 AYLERIEQQLDAvvdanqfnqekieilagltrlrqicchpslflenyqGESGKLELLMTMIEQlRAENRRVLIFSQFSSM 920
Cdd:COG1061 275 ALSERLREALAA------------------------------------DAERKDKILRELLRE-HPDDRKTLVFCSSVDH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 921 LKIIEKELNKQRYQSFYLDGQTPLKDRVEMAEAFNNGEREIfIISLKAGGTGLNLTGADTVILFDLWWNPAVEAQAAGRA 1000
Cdd:COG1061 318 AEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRI-LVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRG 396
|
410
....*....|..
gi 504822311 1001 HRIGQTKKVEVI 1012
Cdd:COG1061 397 LRPAPGKEDALV 408
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
610-810 |
5.46e-18 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 83.49 E-value: 5.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKwfKALARYQLGGILADEMGLGKTIQAIsFILSEKTTE-KIGPSIVIAPASLIYNWKKEFEKFAPTLSVKV 688
Cdd:cd18011 1 PLPHQIDAVL--RALRKPPVRLLLADEVGLGKTIEAG-LIIKELLLRgDAKRVLILCPASLVEQWQDELQDKFGLPFLIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 689 VSGTKDERMTIIKDN-HEPDVWITSYPLLRQDVKLYKHMY---FDVMILDEAQAIKNhlTQTAKATRQIQAKQRFA---- 760
Cdd:cd18011 78 DRETAAQLRRLIGNPfEEFPIVIVSLDLLKRSEERRGLLLseeWDLVVVDEAHKLRN--SGGGKETKRYKLGRLLAkrar 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 504822311 761 ----LSGTPIENRLEELWSIFQTISPGFLGPKKEFIQypNDYIRKITKPFILRR 810
Cdd:cd18011 156 hvllLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLR--LDGLREVLAKVLLRR 207
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
610-775 |
1.26e-14 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 74.31 E-value: 1.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTGFKWFKALARYqlgGILADeMGLGKTIQAISFILSEKTTEKIGPSIVIAPASLIYN-WKKEFEKFA--PTLSV 686
Cdd:cd18013 1 PHPYQKVAINFIIEHPYC---GLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKWNhlRNLTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 687 KVVSGTKDERMTIIkdNHEPDVWITSYPLLRQDVKLYK-HMYFDVMILDEAQAIKNHLTQTAKATRQI--QAKQRFALSG 763
Cdd:cd18013 77 SVAVGTERQRSKAA--NTPADLYVINRENLKWLVNKSGdPWPFDMVVIDELSSFKSPRSKRFKALRKVrpVIKRLIGLTG 154
|
170
....*....|..
gi 504822311 764 TPIENRLEELWS 775
Cdd:cd18013 155 TPSPNGLMDLWA 166
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
884-1057 |
2.58e-10 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 64.75 E-value: 2.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 884 LENYQGESGKLELLMTMIEQLRAENR--RVLIFSQFSSMLKIIEKELNKQRYQSFYLDGQTPL--------KDRVEMAEA 953
Cdd:COG1111 327 AEEADIEHPKLSKLREILKEQLGTNPdsRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQASKegdkgltqKEQIEILER 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 954 FNNGEREIfIISLKAGGTGLNLTGADTVILFDLWWNPAVEAQAAGRAHRIGQTKkveVIRLITQGTIEEKIFQLQERKRK 1033
Cdd:COG1111 407 FRAGEFNV-LVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGR---VVVLIAKGTRDEAYYWSSRRKEK 482
|
170 180
....*....|....*....|....
gi 504822311 1034 LVDEIIQPGETLLSSLNEKELREL 1057
Cdd:COG1111 483 KMKSILKKLKKLLDKQEKEKLKES 506
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
610-765 |
1.03e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 58.09 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 610 LRDYQVTG-FKWFKALARYQlgGILADEMGLGKTI--QAISFILSEKTTekigpsIVIAP-ASLIYNWKKEFEKFAPTLS 685
Cdd:cd17926 1 LRPYQEEAlEAWLAHKNNRR--GILVLPTGSGKTLtaLALIAYLKELRT------LIVVPtDALLDQWKERFEDFLGDSS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 686 VKVVSGTKdermtiIKDNHEPDVWITSYPLLRQDVKLYKHMY--FDVMILDEAqaiknHLTqTAKATRQI----QAKQRF 759
Cdd:cd17926 73 IGLIGGGK------KKDFDDANVVVATYQSLSNLAEEEKDLFdqFGLLIVDEA-----HHL-PAKTFSEIlkelNAKYRL 140
|
....*.
gi 504822311 760 ALSGTP 765
Cdd:cd17926 141 GLTATP 146
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
944-1015 |
3.64e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.55 E-value: 3.64e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504822311 944 LKDRVEMAEAFnngEREI-FIISLKAGGTGLNLTGADTVILFDLWWNPAVEAQAAGRAHRIGQtKKVEVIRLI 1015
Cdd:cd18785 9 FTNSIEHAEEI---ASSLeILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGK-DEGEVILFV 77
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
609-767 |
9.80e-08 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 52.67 E-value: 9.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 609 QLRDYQVTGFK-WFKALARYQLGGILADEMGLGKTIQAISFILSEKTTEKIGPSIVIAP-ASLIYNWKKEFEKFAP--TL 684
Cdd:pfam04851 3 ELRPYQIEAIEnLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPrKDLLEQALEEFKKFLPnyVE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 685 SVKVVSGTKDERmtiikDNHEPDVWITSYP----LLRQDVKLYKHMYFDVMILDEAqaikNHLtqTAKATRQI----QAK 756
Cdd:pfam04851 83 IGEIISGDKKDE-----SVDDNKIVVTTIQslykALELASLELLPDFFDVIIIDEA----HRS--GASSYRNIleyfKPA 151
|
170
....*....|.
gi 504822311 757 QRFALSGTPIE 767
Cdd:pfam04851 152 FLLGLTATPER 162
|
|
| DpdE |
NF041062 |
protein DpdE; |
626-771 |
1.70e-07 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 55.75 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 626 RYqlggILADEMGLGKTIQAiSFILSEKTTEKigPS---IVIAPASLIYNWKKEF-EKFA----PTLSVKVVSgtkderm 697
Cdd:NF041062 172 RY----LLADEVGLGKTIEA-GLVIRQHLLDN--PDarvLVLVPDALVRQWRRELrDKFFlddfPGARVRVLS------- 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 698 tiikdnHE-PDVWITsypllrqdvklyKHMYFDVMILDEAQaiknHLTQTAKATRQIQaKQRFA--------------LS 762
Cdd:NF041062 238 ------HEePERWEP------------LLDAPDLLVVDEAH----QLARLAWSGDPPE-RARYRelaalahaaprlllLS 294
|
....*....
gi 504822311 763 GTPIENRLE 771
Cdd:NF041062 295 ATPVLGNEE 303
|
|
| SWIM |
pfam04434 |
SWIM zinc finger; This domain is found in bacterial, archaeal and eukaryotic proteins. It is ... |
54-91 |
2.15e-05 |
|
SWIM zinc finger; This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organized into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (pfam00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts.
Pssm-ID: 309540 Cd Length: 38 Bit Score: 42.41 E-value: 2.15e-05
10 20 30
....*....|....*....|....*....|....*....
gi 504822311 54 YQVSIFffEDDDLEAKCDCSAYQ-THYTCKHIAAVLLAI 91
Cdd:pfam04434 1 YRVQLD--LDGLEKASCSCPDFQlNGIPCKHALAVLLAL 37
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
892-982 |
1.84e-04 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 43.01 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 892 GKLELLMTMIEQLRaENRRVLIFSQFSSMLKIIEKELNKQryqsfYLDGQTPLKDRVEMAEAFNNGEREIFIISlKAGGT 971
Cdd:cd18789 34 NKLRALEELLKRHE-QGDKIIVFTDNVEALYRYAKRLLKP-----FITGETPQSEREEILQNFREGEYNTLVVS-KVGDE 106
|
90
....*....|.
gi 504822311 972 GLNLTGADTVI 982
Cdd:cd18789 107 GIDLPEANVAI 117
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
891-1053 |
3.98e-04 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 44.13 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 891 SGKLELLMTMIEQLRAEnrRVLIFSQFSSMLKIIEKELNKQRYQSFYLDGQTPLKDRVEMAEAFNNGEREIfIISLKAGG 970
Cdd:PRK01297 320 SDKYKLLYNLVTQNPWE--RVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRV-LVATDVAG 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 971 TGLNLTGADTVILFDLwwnpavEAQAAGRAHRIGQTKkveviRLITQGTI-----EEKIFQLQERK----RKLVDEIiqP 1041
Cdd:PRK01297 397 RGIHIDGISHVINFTL------PEDPDDYVHRIGRTG-----RAGASGVSisfagEDDAFQLPEIEellgRKISCEM--P 463
|
170
....*....|..
gi 504822311 1042 GETLLSSLNEKE 1053
Cdd:PRK01297 464 PAELLKPVPRKH 475
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
630-739 |
1.84e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 40.08 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504822311 630 GGILADEMGLGKTIQAISFILSEkTTEKIGPSIVIAP-ASLIYNWKKEF-EKFAPTLSVKVVSG--TKDERMTIIKDNhe 705
Cdd:cd00046 3 NVLITAPTGSGKTLAALLAALLL-LLKKGKKVLVLVPtKALALQTAERLrELFGPGIRVAVLVGgsSAEEREKNKLGD-- 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 504822311 706 PDVWITSYPLLRQDVKLYKHMY---FDVMILDEAQAI 739
Cdd:cd00046 80 ADIIIATPDMLLNLLLREDRLFlkdLKLIIVDEAHAL 116
|
|
| |
