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Conserved domains on  [gi|737151878|ref|WP_035138783|]
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MULTISPECIES: peptide chain release factor 1 [Collinsella]

Protein Classification

peptide chain release factor 1( domain architecture ID 11415460)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-333 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 613.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   1 MRDKLEKIIKAYEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDTTDADEKEMLQMD 80
Cdd:COG0216    2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  81 ISENEAKLPQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKS 160
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 161 IEFKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEEIDVQINQSDLRIDTYCASGPGGQCVNTTYS 240
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 241 AVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGAERQSQIGHGNRSEKIRTYNQPQDRVTDHRI 320
Cdd:COG0216  242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330
                 ....*....|....*
gi 737151878 321 GFnSTYN--GVLLGD 333
Cdd:COG0216  322 NL-TLYKldEVMEGD 335
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-333 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 613.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   1 MRDKLEKIIKAYEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDTTDADEKEMLQMD 80
Cdd:COG0216    2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  81 ISENEAKLPQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKS 160
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 161 IEFKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEEIDVQINQSDLRIDTYCASGPGGQCVNTTYS 240
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 241 AVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGAERQSQIGHGNRSEKIRTYNQPQDRVTDHRI 320
Cdd:COG0216  242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330
                 ....*....|....*
gi 737151878 321 GFnSTYN--GVLLGD 333
Cdd:COG0216  322 NL-TLYKldEVMEGD 335
prfA PRK00591
peptide chain release factor 1; Validated
 1-339 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 578.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   1 MRDKLEKIIKAYEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDTTDADEKEMLQMD 80
Cdd:PRK00591   4 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  81 ISENEAKLPQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKS 160
Cdd:PRK00591  84 LKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 161 IEFKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEEIDVQINQSDLRIDTYCASGPGGQCVNTTYS 240
Cdd:PRK00591 164 VIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 241 AVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGAERQSQIGHGNRSEKIRTYNQPQDRVTDHRI 320
Cdd:PRK00591 244 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRI 323

                        330       340
                 ....*....|....*....|.
gi 737151878 321 GFNStYN--GVLLGDqLGTVI 339
Cdd:PRK00591 324 NLTL-YKldEVMEGD-LDELI 342
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 3-352 1.30e-166

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 469.17  E-value: 1.30e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878    3 DKLEKIIKAYEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLhDTTDADEKEMLQMDIS 82
Cdd:TIGR00019   7 EKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEIL-EESDPEMREMAKEELE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   83 ENEAKLPQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKSIE 162
Cdd:TIGR00019  86 ELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYKEVI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  163 FKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEEIDVQINQSDLRIDTYCASGPGGQCVNTTYSAV 242
Cdd:TIGR00019 166 AEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDSAV 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  243 RITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGAERQSQIGHGNRSEKIRTYNQPQDRVTDHRIGF 322
Cdd:TIGR00019 246 RITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRINL 325

                         330       340       350
                  ....*....|....*....|....*....|.
gi 737151878  323 N-STYNGVLLGDqLGTVIEALAAAERAEKLA 352
Cdd:TIGR00019 326 TlYKLDEVLEGD-LDELIEALIAEDQAQQLA 355
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-202 2.06e-104

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 304.69  E-value: 2.06e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   12 YEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDttdADEKEMLQMDISENEAKLPQL 91
Cdd:pfam03462   5 YEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLED---PELAELAEEELEELEKRLEEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   92 EEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKSIEFKVEGDRVY 171
Cdd:pfam03462  82 EEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGAY 161

                         170       180       190
                  ....*....|....*....|....*....|.
gi 737151878  172 SVMKYESGVHRVQRVPKTESQGRIQTSTATV 202
Cdd:pfam03462 162 GRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
63-177 1.50e-49

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 161.86  E-value: 1.50e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878    63 EMLHDTTDADEKEMLQMDISENEAKL-PQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESR 141
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELeEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 737151878   142 GWKTTVLDSSPSEAGGFKSIEFKVEGDRVYSVMKYE 177
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-333 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 613.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   1 MRDKLEKIIKAYEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDTTDADEKEMLQMD 80
Cdd:COG0216    2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  81 ISENEAKLPQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKS 160
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 161 IEFKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEEIDVQINQSDLRIDTYCASGPGGQCVNTTYS 240
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 241 AVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGAERQSQIGHGNRSEKIRTYNQPQDRVTDHRI 320
Cdd:COG0216  242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330
                 ....*....|....*
gi 737151878 321 GFnSTYN--GVLLGD 333
Cdd:COG0216  322 NL-TLYKldEVMEGD 335
prfA PRK00591
peptide chain release factor 1; Validated
 1-339 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 578.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   1 MRDKLEKIIKAYEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDTTDADEKEMLQMD 80
Cdd:PRK00591   4 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  81 ISENEAKLPQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKS 160
Cdd:PRK00591  84 LKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 161 IEFKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEEIDVQINQSDLRIDTYCASGPGGQCVNTTYS 240
Cdd:PRK00591 164 VIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 241 AVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGAERQSQIGHGNRSEKIRTYNQPQDRVTDHRI 320
Cdd:PRK00591 244 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRI 323

                        330       340
                 ....*....|....*....|.
gi 737151878 321 GFNStYN--GVLLGDqLGTVI 339
Cdd:PRK00591 324 NLTL-YKldEVMEGD-LDELI 342
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 3-352 1.30e-166

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 469.17  E-value: 1.30e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878    3 DKLEKIIKAYEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLhDTTDADEKEMLQMDIS 82
Cdd:TIGR00019   7 EKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEIL-EESDPEMREMAKEELE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   83 ENEAKLPQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKSIE 162
Cdd:TIGR00019  86 ELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYKEVI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  163 FKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEEIDVQINQSDLRIDTYCASGPGGQCVNTTYSAV 242
Cdd:TIGR00019 166 AEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDSAV 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  243 RITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGAERQSQIGHGNRSEKIRTYNQPQDRVTDHRIGF 322
Cdd:TIGR00019 246 RITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRINL 325

                         330       340       350
                  ....*....|....*....|....*....|.
gi 737151878  323 N-STYNGVLLGDqLGTVIEALAAAERAEKLA 352
Cdd:TIGR00019 326 TlYKLDEVLEGD-LDELIEALIAEDQAQQLA 355
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-202 2.06e-104

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 304.69  E-value: 2.06e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   12 YEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDttdADEKEMLQMDISENEAKLPQL 91
Cdd:pfam03462   5 YEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLED---PELAELAEEELEELEKRLEEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   92 EEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKSIEFKVEGDRVY 171
Cdd:pfam03462  82 EEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGAY 161

                         170       180       190
                  ....*....|....*....|....*....|.
gi 737151878  172 SVMKYESGVHRVQRVPKTESQGRIQTSTATV 202
Cdd:pfam03462 162 GRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 4-333 3.41e-89

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 272.42  E-value: 3.41e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878    4 KLEKIIKAYEELEKKLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEaakeMLHDTTDADEKEMLQMdisE 83
Cdd:TIGR00020  24 DPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLS----ELLELAVEEDDEETFN---E 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878   84 NEAKLPQLEEDIKYMLIP---SDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKS 160
Cdd:TIGR00020  97 LDAELKALEKKLAELELRtmlSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  161 IEFKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEA-EEIDVQINQSDLRIDTYCASGPGGQCVNTTY 239
Cdd:TIGR00020 177 VTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVdDDIDIEIKPEDLRIDTYRASGAGGQHVNKTD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  240 SAVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGA--ERQSQIGHGNrseKIRTYN-QPQDRVT 316
Cdd:TIGR00020 257 SAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAkeGEKSEIGWGS---QIRSYVlHPYSMVK 333

                         330
                  ....*....|....*...
gi 737151878  317 DHRIGF-NSTYNGVLLGD 333
Cdd:TIGR00020 334 DLRTGYeTGNVQAVLDGD 351
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 55-333 1.86e-67

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 214.91  E-value: 1.86e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  55 LDDIEAAKEMLHDTTDADEKEMLQM---DISENEAKLPQLEedikYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLY 131
Cdd:PRK08787  13 LSGLADAGELLDLAESEQDEDTALAviaDLDKYQAHVEKLE----FQRMFSGQMDGANAFVDIQAGAGGTEAQDWAEILL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 132 KMYQRFCESRGWKTTVLDSSPSEAGGFKSIEFKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEE- 210
Cdd:PRK08787  89 RMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDn 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 211 IDVQINQSDLRIDTYCASGPGGQCVNTTYSAVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGA 290
Cdd:PRK08787 169 IEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRNAEKDA 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 737151878 291 --ERQSQIGHGNrseKIRTYNQPQDRVTDHRIGFN-STYNGVLLGD 333
Cdd:PRK08787 249 leATKSDIGWGS---QIRNYVLDQSRIKDLRTGIErSDTQKVLDGD 291
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 18-333 5.51e-61

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 198.95  E-value: 5.51e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  18 KLSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDTTDADEkemlqmdISENEAKLPQLEEDIKY 97
Cdd:PRK07342   2 KAEDPSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDNIELIAMGEEEGDKSI-------VEDAEKTIRDLKDEIDR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  98 MLI------PSDPNDdknTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKSIEFKVEGDRVY 171
Cdd:PRK07342  75 RQIdallsgEADAND---TYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAY 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 172 SVMKYESGVHRVQRVPKTESQGRIQTSTATVAVLPEAEE-IDVQINQSDLRIDTYCASGPGGQCVNTTYSAVRITHLPTN 250
Cdd:PRK07342 152 GWLKTESGVHRLVRISPYDSNARRHTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 251 TVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAELGAERQSQ--IGHGNrseKIRTYN-QPQDRVTDHRIGFNSTYN 327
Cdd:PRK07342 232 IVVQCQQERSQHKNRAKAWSMLRARLYEEELKKREEATNAAAASKtdIGWGH---QIRSYVlQPYQLVKDLRTGVESTNP 308


                 ....*..
gi 737151878 328 G-VLLGD 333
Cdd:PRK07342 309 QdVLDGD 315
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 43-319 1.59e-60

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 197.26  E-value: 1.59e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  43 DLIAASREYIGALDDIEAAKEMLHDTTDADEKEMLQMDISeneaKLPQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDE 122
Cdd:PRK06746  25 DMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVK----GLIQEMNEYELQLLLSDPYDKNNAILELHPGAGGTE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 123 AAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKSIEFKVEGDRVYSVMKYESGVHRVQRVPKTESQGRIQTSTATV 202
Cdd:PRK06746 101 SQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSC 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 203 AVLPE-AEEIDVQINQSDLRIDTYCASGPGGQCVNTTYSAVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMEL 281
Cdd:PRK06746 181 EVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKL 260

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 737151878 282 EKQQAELGAER--QSQIGHGNrseKIRTYN-QPQDRVTDHR 319
Cdd:PRK06746 261 EEQQAELDEIRgeQKEIGWGS---QIRSYVfHPYSLVKDHR 298
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 19-333 2.95e-60

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 196.56  E-value: 2.95e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  19 LSDPAVASDIKEFTRLNKEYAHQSDLIAASREYIGALDDIEAAKEMLHDTTDADEKEMLQmDISENEAKLpqleEDIKYM 98
Cdd:PRK05589   1 MQEPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEEDDEMKKEIIS-EVKNIKEEI----DRFKIE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  99 LIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEAGGFKSIEFKVEGDRVYSVMKYES 178
Cdd:PRK05589  76 TLLSGEYDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 179 GVHRVQRVPKTESQGRIQTSTATVAVLPE-AEEIDVQINQSDLRIDTYCASGPGGQCVNTTYSAVRITHLPTNTVVQSQE 257
Cdd:PRK05589 156 GIHRLVRISPFNANGKRQTSFASVEVLPElTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQN 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 258 QRSQIQNREVCMQMLRARLYEME--LEKQQAELGAERQSQIGHGNrseKIRTYN-QPQDRVTDHRIGF-NSTYNGVLLGD 333
Cdd:PRK05589 236 ERSQHSNKETAMKMLKSKLVELKerAHKEKIEDLTGELKDMGWGS---QIRSYVfHPYNLVKDHRTGVeTSNVDSVMDGD 312
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 209-319 5.64e-58

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 183.39  E-value: 5.64e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  209 EEIDVQINQSDLRIDTYCASGPGGQCVNTTYSAVRITHLPTNTVVQSQEQRSQIQNREVCMQMLRARLYEMELEKQQAEL 288
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKK 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 737151878  289 gAERQSQIGHGNRSEKIRTYN-QPQDRVTDHR 319
Cdd:pfam00472  81 -RRIKSQVGSGDRSEQIRTYNfKPQSRVKDHR 111
PCRF smart00937
This domain is found in peptide chain release factors;
63-177 1.50e-49

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 161.86  E-value: 1.50e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878    63 EMLHDTTDADEKEMLQMDISENEAKL-PQLEEDIKYMLIPSDPNDDKNTIVEIRSAAGGDEAAIFAGDLYKMYQRFCESR 141
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELeEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 737151878   142 GWKTTVLDSSPSEAGGFKSIEFKVEGDRVYSVMKYE 177
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 212-319 1.30e-31

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 116.00  E-value: 1.30e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 212 DVQINQSDLRIDTYCASGPGGQCVNTTYSAVRITH------------LPTNTVVQSQEQRSQIQNREVCMQMLRARLYEM 279
Cdd:COG1186   20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 737151878 280 ELEKQQAElgAERQSQIGHGNRSE--KIRTynqpqdRVTDHR 319
Cdd:COG1186  100 ELEPKERR--ATKPTRGSKKRRLWgkQIRS------MVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 110-308 5.43e-21

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 89.45  E-value: 5.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  110 TIVEIRSAAGGDEAAIFAGDLYKMYQRFCESRGWKTTVLDSSPSEA-GGFKSIEFKVEGDRVYSVM-KYESGVHRVQRVP 187
Cdd:TIGR03072   1 ILLQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVpGTLRSALVSLDGEAAAALAdRWEGTLLWICPSP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878  188 KTESQGRiqtSTATVAVLPEAEEIDvqINQSDLRIDTYCASGPGGQCVNTTYSAVRITHLPTNTVVQSQEQRSQIQNREV 267
Cdd:TIGR03072  81 YRPHHRR---KNWFIGVQRFSASEE--ATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRL 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 737151878  268 CMQMLRARLYEMELEkQQAELGAERQSQIGHGNRSEKIRTY 308
Cdd:TIGR03072 156 ATLLLAVRLADLQQE-QAAALRAERRTAHHQIERGNPVRVF 195
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
212-279 1.02e-05

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 44.76  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737151878 212 DVQINQSDLRIDTYCASGPGGQCVNTTYSAV------RITHLPTNT------------------VVQSQEQRSQIQNREV 267
Cdd:PRK09256   7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVelrfdiAASSLPEFYkerllalaghritkdgviVIKAQEFRSQERNRED 86

                         90
                 ....*....|..
gi 737151878 268 CmqmlRARLYEM 279
Cdd:PRK09256  87 A----LERLVAL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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