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Conserved domains on  [gi|1469306671|ref|WP_117648125|]
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MULTISPECIES: LytTR family DNA-binding domain-containing protein [unclassified Collinsella]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-239 3.04e-84

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 250.50  E-value: 3.04e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:COG3279     3 KILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  86 AFAEYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALGVRRVIHAPRQPL-RLTVDRGGKKVFIPAADVCYFEARADFC 164
Cdd:COG3279    83 AYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKdRIFVKSGGKLVKIPLDDILYIEAEGNYV 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1469306671 165 NAICAEGTYLINESISSLERRLDSEGFIRVHRSYLVNLEDVHNVEIGSTGLMELRLDrvnSTVPVSRRRAAEVKS 239
Cdd:COG3279   163 KIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGEVVLKNG---EEIPVSRRYKKEFKE 234
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-239 3.04e-84

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 250.50  E-value: 3.04e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:COG3279     3 KILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  86 AFAEYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALGVRRVIHAPRQPL-RLTVDRGGKKVFIPAADVCYFEARADFC 164
Cdd:COG3279    83 AYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKdRIFVKSGGKLVKIPLDDILYIEAEGNYV 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1469306671 165 NAICAEGTYLINESISSLERRLDSEGFIRVHRSYLVNLEDVHNVEIGSTGLMELRLDrvnSTVPVSRRRAAEVKS 239
Cdd:COG3279   163 KIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGEVVLKNG---EEIPVSRRYKKEFKE 234
PRK11697 PRK11697
two-component system response regulator BtsR;
6-243 2.05e-54

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 174.65  E-value: 2.05e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLqNLKTPPVVVFVT 85
Cdd:PRK11697    3 KVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGML-DPEHMPYIVFVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  86 AFAEYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALGVRRVIHAPRQ-PLRLTVDRGGKKVF-IPAADVCYFEARADF 163
Cdd:PRK11697   82 AFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDVLLPEAQpPLKHIPCTGHNRIKlLPLEEVEFVSSRLSG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671 164 CNAICAEGTYLINESISSLERRldsEGFIRVHRSYLVNLEDVHNVEIGSTGLMELRLdRVNSTVPVSRRRAAEVKSHLGL 243
Cdd:PRK11697  162 VHVVSAEGKGFTELTLKTLEEK---TPLLRCHRQYLVNPAAIQEIRLLDNGQAEIIT-RSGHTVPVSRRYLKSLKEALGL 237
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 7-124 2.53e-47

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 152.69  E-value: 2.53e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1469306671  87 FAEYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALG 124
Cdd:cd17532    81 YDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 144-240 2.32e-26

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 98.03  E-value: 2.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  144 GKKVFIPAADVCYFEARADFCNAICAEGTYLINESISSLERRLDSEGFIRVHRSYLVNLEDVHNVEIGSTGLMELRLDRv 223
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILKN- 79

                           90
                   ....*....|....*..
gi 1469306671  224 NSTVPVSRRRAAEVKSH 240
Cdd:smart00850  80 GEEVPVSRRYLKELKER 96
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-117 2.32e-26

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 98.76  E-value: 2.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVghIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYV--VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1469306671  87 FAE--YAADAYNLDAVDYVVKPVEDARLSKALD 117
Cdd:pfam00072  79 HGDedDAVEALEAGADDFLSKPFDPDELLAAIR 111
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 7-114 1.33e-09

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 56.73  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELR-YL-LEKDTRVGHIAEAGNvtEAVESILSNKPDVLFLDITMPGRSGIELAETLQN--LKTPPVVV 82
Cdd:TIGR02875   5 IVIADDNKEFCNLLKeYLaAQPDMEVVGVAHNGV--DALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEieLSARPRVI 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1469306671  83 FVTAFAE--YAADAYNLDAVDYVVKPVEDARLSK 114
Cdd:TIGR02875  83 MLSAFGQekITQRAVALGADYYVLKPFDLEILAA 116
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-239 3.04e-84

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 250.50  E-value: 3.04e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:COG3279     3 KILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  86 AFAEYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALGVRRVIHAPRQPL-RLTVDRGGKKVFIPAADVCYFEARADFC 164
Cdd:COG3279    83 AYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKdRIFVKSGGKLVKIPLDDILYIEAEGNYV 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1469306671 165 NAICAEGTYLINESISSLERRLDSEGFIRVHRSYLVNLEDVHNVEIGSTGLMELRLDrvnSTVPVSRRRAAEVKS 239
Cdd:COG3279   163 KIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGEVVLKNG---EEIPVSRRYKKEFKE 234
PRK11697 PRK11697
two-component system response regulator BtsR;
6-243 2.05e-54

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 174.65  E-value: 2.05e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLqNLKTPPVVVFVT 85
Cdd:PRK11697    3 KVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGML-DPEHMPYIVFVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  86 AFAEYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALGVRRVIHAPRQ-PLRLTVDRGGKKVF-IPAADVCYFEARADF 163
Cdd:PRK11697   82 AFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDVLLPEAQpPLKHIPCTGHNRIKlLPLEEVEFVSSRLSG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671 164 CNAICAEGTYLINESISSLERRldsEGFIRVHRSYLVNLEDVHNVEIGSTGLMELRLdRVNSTVPVSRRRAAEVKSHLGL 243
Cdd:PRK11697  162 VHVVSAEGKGFTELTLKTLEEK---TPLLRCHRQYLVNPAAIQEIRLLDNGQAEIIT-RSGHTVPVSRRYLKSLKEALGL 237
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 7-124 2.53e-47

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 152.69  E-value: 2.53e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1469306671  87 FAEYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALG 124
Cdd:cd17532    81 YDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
PRK14084 PRK14084
DNA-binding response regulator;
6-209 1.19e-41

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 142.20  E-value: 1.19e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:PRK14084    2 KALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFAT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  86 AFAEYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALG-VRRVIHAPRQPLR------LTVDRGGKKVFIPAADVCYFE 158
Cdd:PRK14084   82 AHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATKAkDDNNASAIANDMSanfdqsLPIEIDDKIHMLNQQDIIAIG 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1469306671 159 ARADFCNAICAEGTYLINESISSLERRLDSEGFIRVHRSYLVNLEDVHNVE 209
Cdd:PRK14084  162 VHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINKKHIKEVE 212
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 6-106 6.20e-31

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 110.25  E-value: 6.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                          90       100
                  ....*....|....*....|...
gi 1469306671  86 AFA--EYAADAYNLDAVDYVVKP 106
Cdd:COG4753    81 GYSdfEYAQEAIKLGADDYLLKP 103
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 7-123 1.30e-29

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 107.42  E-value: 1.30e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLE-KDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:cd17536     1 VLIVDDEPLIREGLKKLIDwEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1469306671  86 AFA--EYAADAYNLDAVDYVVKPVEDARLSKALDKIEAAL 123
Cdd:cd17536    81 GYDdfEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEEL 120
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 144-240 2.32e-26

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 98.03  E-value: 2.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  144 GKKVFIPAADVCYFEARADFCNAICAEGTYLINESISSLERRLDSEGFIRVHRSYLVNLEDVHNVEIGSTGLMELRLDRv 223
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILKN- 79

                           90
                   ....*....|....*..
gi 1469306671  224 NSTVPVSRRRAAEVKSH 240
Cdd:smart00850  80 GEEVPVSRRYLKELKER 96
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-117 2.32e-26

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 98.76  E-value: 2.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVghIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYV--VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1469306671  87 FAE--YAADAYNLDAVDYVVKPVEDARLSKALD 117
Cdd:pfam00072  79 HGDedDAVEALEAGADDFLSKPFDPDELLAAIR 111
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 5-119 6.51e-26

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 98.12  E-value: 6.51e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   5 WNILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:COG4565     4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVI 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1469306671  85 TAFAEYA--ADAYNLDAVDYVVKPVEDARLSKALDKI 119
Cdd:COG4565    84 TAARDPEtvREALRAGVVDYLIKPFTFERLREALERY 120
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 144-242 1.78e-24

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 93.42  E-value: 1.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671 144 GKKVFIPAADVCYFEARADFCNAICAEGTYLINESISSLERRLDSEGFIRVHRSYLVNLEDVHNVEIGSTGLMELRLDRv 223
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDFNGTYELTLKN- 79

                          90
                  ....*....|....*....
gi 1469306671 224 NSTVPVSRRRAAEVKSHLG 242
Cdd:pfam04397  80 GEKIPVSRRYLKELKELLG 98
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-138 5.07e-24

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 99.27  E-value: 5.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:COG2204     4 RILVVDDDPDIRRLLKELLERA---GYeVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1469306671  85 TAFA--EYAADAYNLDAVDYVVKPVEDARLskaLDKIEAALGVRRVIHAPRQPLRL 138
Cdd:COG2204    81 TGYGdvETAVEAIKAGAFDYLTKPFDLEEL---LAAVERALERRRLRRENAEDSGL 133
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 6-139 2.39e-23

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 94.08  E-value: 2.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRvgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPP--VVVF 83
Cdd:COG3437     8 TVLIVDDDPENLELLRQLLRTLGY--DVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRdiPVIF 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1469306671  84 VTAFA--EYAADAYNLDAVDYVVKPVEDARLskaLDKIEAALGVRRVIHAPRQPLRLT 139
Cdd:COG3437    86 LTALAdpEDRERALEAGADDYLTKPFDPEEL---LARVRNALELRRLQRELDDLVLYL 140
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 8-106 1.46e-22

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 88.44  E-value: 1.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   8 LVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd00156     1 LIVDDDPAIRELLKSLLERE---GYeVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTA 77

                          90       100
                  ....*....|....*....|..
gi 1469306671  87 FA--EYAADAYNLDAVDYVVKP 106
Cdd:cd00156    78 KAdeEDAVRALELGADDYLVKP 99
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 2-119 7.04e-22

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 87.60  E-value: 7.04e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   2 SEGWNILVVDDEPPIRAELRYLLEkdtRVGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL-QNLKTPP 79
Cdd:COG0784     3 LGGKRILVVDDNPDNRELLRRLLE---RLGYeVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIrALPRLPD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1469306671  80 V-VVFVTAFA--EYAADAYNLDAVDYVVKPVEDARLSKALDKI 119
Cdd:COG0784    80 IpIIALTAYAdeEDRERALEAGADDYLTKPVDPEELLEALRRL 122
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 7-151 5.48e-21

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 87.32  E-value: 5.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL--QNLKTPpvVVF 83
Cdd:COG0745     4 ILVVEDDPDIRELLADALERE---GYeVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLraRPSDIP--IIM 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1469306671  84 VTAFAEYA--ADAYNLDAVDYVVKPVEDARLskaLDKIEAALgvRRVIHAPRQ------PLRLTVDRGGKKVFIPA 151
Cdd:COG0745    79 LTARDDEEdrVRGLEAGADDYLTKPFDPEEL---LARIRALL--RRRAAEVLRvgdlldLAAREVTRDGEPVELTP 149
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 7-119 7.56e-21

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 86.12  E-value: 7.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL-QNLKTPPV-VVF 83
Cdd:COG3706     4 ILVVDDDPTNRKLLRRLLEAA---GYeVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLrADPRTADIpIIF 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1469306671  84 VTAFA--EYAADAYNLDAVDYVVKPVEDARLSKALDKI 119
Cdd:COG3706    81 LTALDdeEDRARALEAGADDYLTKPFDPEELLARVDLV 118
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 7-119 2.80e-20

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 82.95  E-value: 2.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1469306671  87 F--AEYAADAYNLDAVDYVVKPVEDARLSKALDKI 119
Cdd:cd17535    81 HddPEYVLRALKAGAAGYLLKDSSPEELIEAIRAV 115
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
 6-106 6.49e-18

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 76.76  E-value: 6.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:COG5803     4 KILIVDDQAGIRMLLKEVLKKE---GYeVFQAANGKEALEKVKELKPDLVLLDMKMPGMDGIEILKEIKEIDPDIPVIMM 80

                          90       100
                  ....*....|....*....|....
gi 1469306671  85 TAFAEYA--ADAYNLDAVDYVVKP 106
Cdd:COG5803    81 TAYGELDmvEEAKELGAKGYFTKP 104
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 6-123 1.21e-17

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 75.91  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKdtrVGH--IAEAGNVTEAVESILSNKPDVLFLDITMPG-RSGIELAETLQNLKTPPvVV 82
Cdd:cd17534     2 KILIVEDEAIIALDLKEILES---LGYevVGIADSGEEAIELAEENKPDLILMDINLKGdMDGIEAAREIREKFDIP-VI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1469306671  83 FVTAFA--EYAADAYNLDAVDYVVKPVEDARLSKAldkIEAAL 123
Cdd:cd17534    78 FLTAYSdeETLERAKETNPYGYLVKPFNERELKAA---IELAL 117
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 6-105 1.44e-17

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 75.72  E-value: 1.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:cd17554     2 KILVVDDEENIRELYKEELEDE---GYeVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIIC 78

                          90       100
                  ....*....|....*....|.
gi 1469306671  85 TAFAEYAADAYNLDAVDYVVK 105
Cdd:cd17554    79 TAYSEYKSDFSSWAADAYVVK 99
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 4-129 1.71e-17

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 77.69  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   4 GWNILVVDDEPPIRAELRYLLEkdtRVGH--IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVV 81
Cdd:COG3707     3 GLRVLVVDDEPLRRADLREGLR---EAGYevVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1469306671  82 VFV----TAFAEYAADAynlDAVDYVVKPV-----------------EDARLSKALDKIEAALGVRRVI 129
Cdd:COG3707    80 LLTaysdPELIERALEA---GVSAYLVKPLdpedllpalelalarfrELRALRRELAKLREALEERKLI 145
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 6-119 5.69e-17

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 74.24  E-value: 5.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDtrvGH--IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVF 83
Cdd:cd17542     2 KVLIVDDAAFMRMMLKDILTKA---GYevVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIM 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1469306671  84 VTAFAEYAA--DAYNLDAVDYVVKPVEDARLSKALDKI 119
Cdd:cd17542    79 CSAMGQEEMvkEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 7-117 8.25e-17

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 73.99  E-value: 8.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGH--IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPvVVFV 84
Cdd:cd19932     3 VLIAEDEALIRMDLREMLEEA---GYevVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAP-IVLL 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1469306671  85 TAFA--EYAADAYNLDAVDYVVKPVEDARLSKALD 117
Cdd:cd19932    79 TAYSqqDLVERAKEAGAMAYLVKPFSESDLIPAIE 113
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 5-118 9.18e-17

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 73.82  E-value: 9.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   5 WNILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:cd19925     1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1469306671  85 TAFAEYAA--DAYNLDAVDYVVKPVEDARLSKALDK 118
Cdd:cd19925    81 TAANDVETvrEALRLGVVDYLIKPFTFERLRQRLER 116
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 6-128 1.90e-16

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 72.81  E-value: 1.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVF-- 83
Cdd:cd17541     2 RVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPTPVVMVss 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1469306671  84 -VTAFAEYAADAYNLDAVDYVVKPVEDArlSKALDKIEAALgVRRV 128
Cdd:cd17541    82 lTEEGAEITLEALELGAVDFIAKPSGGI--SLDLEEIAEEL-IEKI 124
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 7-142 4.19e-16

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 73.98  E-value: 4.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEkdtRVGHIAEA-GNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:COG4566     2 VYIVDDDEAVRDSLAFLLE---SAGLRVETfASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1469306671  86 AFA--EYAADAYNLDAVDYVVKPVEDARLskaLDKIEAALGVRRVIHAPRQPLRLTVDR 142
Cdd:COG4566    79 GHGdvPMAVRAMKAGAVDFLEKPFDDQAL---LDAVRRALARDRARRAERARRAELRAR 134
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
7-137 5.84e-16

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 75.96  E-value: 5.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT- 85
Cdd:PRK00742    6 VLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRPTPVVMVSSl 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1469306671  86 --AFAEYAADAYNLDAVDYVVKPVEDarLSKALDKIEAALgVRRVIHAPRQPLR 137
Cdd:PRK00742   86 teRGAEITLRALELGAVDFVTKPFLG--ISLGMDEYKEEL-AEKVRAAARARVR 136
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 8-106 6.21e-16

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 70.90  E-value: 6.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   8 LVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL-QNLKTPPvVVFVT 85
Cdd:cd17574     1 LVVEDDEEIAELLSDYLEKE---GYeVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLrEKGSDIP-IIMLT 76

                          90       100
                  ....*....|....*....|....
gi 1469306671  86 AFAEyAAD---AYNLDAVDYVVKP 106
Cdd:cd17574    77 AKDE-EEDkvlGLELGADDYITKP 99
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 6-72 1.64e-15

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 70.69  E-value: 1.64e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL 72
Cdd:COG2197     3 RVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 7-123 3.69e-15

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 69.16  E-value: 3.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtrVGHIAEAGNVTEA-VESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:cd17537     3 VYVVDDDEAVRDSLAFLLRS---VGLAVKTFTSASAfLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFIT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1469306671  86 AFAE--YAADAYNLDAVDYVVKPVEDARLskaLDKIEAAL 123
Cdd:cd17537    80 GHGDvpMAVEAMKAGAVDFLEKPFRDQVL---LDAIEQAL 116
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 7-121 3.77e-15

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 69.22  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd19930     1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1469306671  87 FAE--YAADAYNLDAVDYVVKPVEDARLSKALDKIEA 121
Cdd:cd19930    81 FGRpgYFRRALAAGVDGYVLKDRPIEELADAIRTVHA 117
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 6-123 1.43e-14

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 67.66  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEkdtRVGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL---QNLKTPPVV 81
Cdd:cd17618     2 TILIVEDEPAIREMIAFNLE---RAGFdVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLkrdEMTRDIPII 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1469306671  82 VfVTAFAEYAADAYNLD--AVDYVVKPVEDARLskaLDKIEAAL 123
Cdd:cd17618    79 M-LTARGEEEDKVRGLEagADDYITKPFSPREL---VARIKAVL 118
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 7-116 2.23e-14

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 67.10  E-value: 2.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL---QNLKTPPVVV 82
Cdd:cd17580     1 ILVVDDNEDAAEMLALLLELE---GAEVTtAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLrelPWLANTPAIA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1469306671  83 fVTAFA-----EYAADA-YNLdavdYVVKPVEDARLSKAL 116
Cdd:cd17580    78 -LTGYGqpedrERALEAgFDA----HLVKPVDPDELIELI 112
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 7-107 4.50e-14

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 66.00  E-value: 4.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPP-IRAELRYLLEKDTRVGhIAEAGNvtEAVESILSNKPDVLFLDITMPGRSGIELAETL-QNLKT---PpvV 81
Cdd:cd19920     1 ILIVDDVPDnLRLLSELLRAAGYRVL-VATDGQ--QALQRAQAEPPDLILLDVMMPGMDGFEVCRRLkADPATrhiP--V 75

                          90       100
                  ....*....|....*....|....*....
gi 1469306671  82 VFVTAFAEyAAD---AYNLDAVDYVVKPV 107
Cdd:cd19920    76 IFLTALTD-TEDkvkGFELGAVDYITKPF 103
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 7-116 1.02e-13

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 65.57  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtrVGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL----QNLKTPPVV 81
Cdd:cd17546     1 VLVVDDNPVNRKVLKKLLEK---LGYEVDvAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIreleGGGRRTPII 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1469306671  82 VfVTAFAEYAADAYNLDAV--DYVVKPVEDARLSKAL 116
Cdd:cd17546    78 A-LTANALEEDREKCLEAGmdDYLSKPVKLDQLKEVL 113
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 7-109 1.13e-13

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 65.30  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELR-YLLEKDTRVghiAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNL--KTPPVVVF 83
Cdd:cd17555     3 ILVIDDDEVVRESIAaYLEDSGFQV---LQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKEspDTPVIVVS 79

                          90       100
                  ....*....|....*....|....*.
gi 1469306671  84 VTAFAEYAADAYNLDAVDYVVKPVED 109
Cdd:cd17555    80 GAGVMSDAVEALRLGAWDYLTKPIED 105
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 7-112 1.47e-13

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 65.30  E-value: 1.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELR-YLLEKDTRVGHiAEAGnvTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:cd17572     1 VLLVEDSPSLAALYQeYLSDEGYKVTH-VETG--KEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVIT 77

                          90       100
                  ....*....|....*....|....*....
gi 1469306671  86 AFA--EYAADAYNLDAVDYVVKPVEDARL 112
Cdd:cd17572    78 AHGsvDIAVEAMRLGAYDFLEKPFDADRL 106
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 6-118 1.04e-12

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 62.94  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:cd17593     2 KVLICDDSSMARKQLARALPADWDV-EITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVS 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1469306671  86 A--FAEYAADAYNLDAVDYVVKPVEDARLSKALDK 118
Cdd:cd17593    81 GdvQPEAKERVLELGALAFLKKPFDPEKLAQLLEE 115
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
1-136 1.42e-12

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 66.41  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   1 MSEGWNILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPP 79
Cdd:PRK11361    1 MTAINRILIVDDEDNVRRMLSTAFALQ---GFeTHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRT 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1469306671  80 VVVFVTAFAEY--AADAYNLDAVDYVVKPVEDARLSKALDKIEAALGVRRVIHAPRQPL 136
Cdd:PRK11361   78 PVILMTAYAEVetAVEALRCGAFDYVIKPFDLDELNLIVQRALQLQSMKKEIRHLHQAL 136
fixJ PRK09390
response regulator FixJ; Provisional
 1-123 3.31e-12

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 63.48  E-value: 3.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   1 MSEGwNILVVDDEPPIRAELRYLLEKDtrvGHiaeAGNVTEAVESILSNKPDVLF----LDITMPGRSGIELAETLQNLK 76
Cdd:PRK09390    1 SDKG-VVHVVDDDEAMRDSLAFLLDSA---GF---EVRLFESAQAFLDALPGLRFgcvvTDVRMPGIDGIELLRRLKARG 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1469306671  77 TPPVVVFVTAFAE--YAADAYNLDAVDYVVKPVEDARLskaLDKIEAAL 123
Cdd:PRK09390   74 SPLPVIVMTGHGDvpLAVEAMKLGAVDFIEKPFEDERL---IGAIERAL 119
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 1-114 3.51e-12

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 64.44  E-value: 3.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   1 MSEGWNILVVDDEPPIRAELR-YL-LEKDTRVghIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQ--NLK 76
Cdd:COG5801     1 MMEKIKVLIADDNREFCELLEeYLsSQPDMEV--VGVAYNGLEALELIEEKKPDVVILDIIMPHLDGLGVLEKLRemNLE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1469306671  77 TPPVVVFVTAFA--EYAADAYNLDAVDYVVKPVEDARLSK 114
Cdd:COG5801    79 KRPKVIMLTAFGqeDITQRAVELGADYYILKPFDLDVLAE 118
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 6-126 4.44e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 60.92  E-value: 4.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLK---TPPVVV 82
Cdd:cd17551     2 RILIVDDNPTNLLLLEALLRSAGYL-EVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPgleDVPIVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1469306671  83 fVTAFAE----YAAdaynLD--AVDYVVKPVedarlskalDKIEAALGVR 126
Cdd:cd17551    81 -ITADTDrevrLRA----LEagATDFLTKPF---------DPVELLARVR 116
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 6-118 4.89e-12

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 61.02  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEkdtRVGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL---QNLKTPPVV 81
Cdd:cd17548     1 KILIVEDNPLNMKLARDLLE---SAGYeVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLkedPATRDIPVI 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1469306671  82 VfVTAFAEYAADAYNLDA--VDYVVKPVEDARLSKALDK 118
Cdd:cd17548    78 A-LTAYAMKGDREKILEAgcDGYISKPIDTREFLETVAK 115
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 6-142 5.99e-12

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 62.24  E-value: 5.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEkdtRVGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:COG4567     6 SLLLVDDDEAFARVLARALE---RRGFeVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1469306671  85 TAFA--EYAADAYNLDAVDYVVKPVeDArlskalDKIEAALGvRRVIHAPRQPLR-LTVDR 142
Cdd:COG4567    83 TGYAsiATAVEAIKLGADDYLAKPA-DA------DDLLAALE-RAEGDAPAPPENpMSLDR 135
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 7-112 6.92e-12

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 60.59  E-value: 6.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQ--NLKTPPVVVF 83
Cdd:cd17550     1 ILIVDDEEDIRESLSGILEDE---GYeVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKekYPDLPVIMIS 77

                          90       100
                  ....*....|....*....|....*....
gi 1469306671  84 VTAFAEYAADAYNLDAVDYVVKPVEDARL 112
Cdd:cd17550    78 GHGTIETAVKATKLGAYDFIEKPLSLDRL 106
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 7-139 1.47e-11

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 59.87  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtrVG--HIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQ-NLKTPPV-VV 82
Cdd:cd17552     4 ILVIDDEEDIREVVQACLEK---LAgwEVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQaNPETQSIpVI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1469306671  83 FVTAfaeyaadaynldavdyVVKPVEDARLskaldkieAALGVRRVIHAPRQPLRLT 139
Cdd:cd17552    81 LLTA----------------KAQPSDRQRF--------ASLGVAGVIAKPFDPLTLA 113
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 7-119 2.05e-11

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 59.28  E-value: 2.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIelaETLQNLK----TPPVVV 82
Cdd:cd19931     1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGL---DTLKALReegvSARIVI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1469306671  83 FVTAFAEyaADAYNL---DAVDYVVKPVEDARLSKALDKI 119
Cdd:cd19931    78 LTVSDAE--DDVVTAlraGADGYLLKDMEPEDLLEALKQA 115
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 7-107 2.23e-11

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 58.66  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL-QNLKTPPV-VVF 83
Cdd:cd17538     2 ILVVDDEPANRELLEALLSAE---GYeVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLkEDPETRHIpVIM 78

                          90       100
                  ....*....|....*....|....*.
gi 1469306671  84 VTAF--AEYAADAYNLDAVDYVVKPV 107
Cdd:cd17538    79 ITALddREDRIRGLEAGADDFLSKPI 104
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 6-119 2.25e-11

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 59.27  E-value: 2.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLeKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQ---NLKTPPVVV 82
Cdd:cd19923     2 KVLVVDDFSTMRRIIKNLL-KELGFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRadgALSHLPVLM 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1469306671  83 fVTAFA--EYAADAYNLDAVDYVVKPVEDARLSKALDKI 119
Cdd:cd19923    81 -VTAEAkkENVIAAAQAGVNNYIVKPFTAATLKEKLEKI 118
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 7-106 2.27e-11

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 58.72  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLE-KDTRVghiAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVfVT 85
Cdd:cd17620     1 ILVIEDEPQIRRFLRTALEaHGYRV---FEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWSAVPVIV-LS 76

                          90       100
                  ....*....|....*....|...
gi 1469306671  86 AFAEYAA--DAYNLDAVDYVVKP 106
Cdd:cd17620    77 ARDEESDkiAALDAGADDYLTKP 99
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 1-124 2.29e-11

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 61.20  E-value: 2.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   1 MSEGWNILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIelaETLQNLKTPP- 79
Cdd:PRK10651    3 NQEPATILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGL---ETLDKLREKSl 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1469306671  80 ---VVVF-VTAFAEYAADAYNLDAVDYVVKPVEDARLSKALDkiEAALG 124
Cdd:PRK10651   80 sgrIVVFsVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQ--QAAAG 126
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
6-86 4.14e-11

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 60.29  E-value: 4.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDtRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:PRK09958    2 NAIIIDDHPLAIAAIRNLLIKN-DIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVS 80


                  .
gi 1469306671  86 A 86
Cdd:PRK09958   81 A 81
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 6-123 4.86e-11

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 58.22  E-value: 4.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEkdtRVGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:cd17563     2 SLLLVDDDEVFAERLARALE---RRGFEVEtAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1469306671  85 TAFAEYAA--DAYNLDAVDYVVKPVEdarlskaLDKIEAAL 123
Cdd:cd17563    79 TGYASIATavEAIKLGADDYLAKPAD-------ADEILAAL 112
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 7-89 6.88e-11

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 58.03  E-value: 6.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEkdtRVGH--IAEAGNVTEAVESILSNKPDVLFLDITMP-GRSGIELAETLQNLKTPPvVVF 83
Cdd:cd17540     3 VLIIEDEPLIAMDLEQIVE---DLGHqvVGIARTRDEAVALARRERPDLILADIQLAdGSSGIDAVNEILTTHDVP-VIF 78


                  ....*.
gi 1469306671  84 VTAFAE 89
Cdd:cd17540    79 VTAYPE 84
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 6-121 1.17e-10

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 57.45  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEkDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:cd17530     2 RVLVLDDDPFQCMMAATILE-DLGPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1469306671  86 AF-------AEYAADAYNLDAVDYVVKPVEDARLSKALDKIEA 121
Cdd:cd17530    81 GLdggilesAETLAGANGLNLLGTLSKPFSPEELTELLTKYTA 123
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 7-61 1.84e-10

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 54.88  E-value: 1.84e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1469306671    7 ILVVDDEPPIRAELRYLLEKDTrvGHIAEAGNVTEAVESILSNKPDVLFLDITMP 61
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEG--YEVDEATDGEEALELLKEEKPDLILLDIMMP 55
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-120 1.91e-10

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 58.88  E-value: 1.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   1 MSEGWNILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPV 80
Cdd:PRK10046    1 MTAPLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1469306671  81 VVFVTAFA--EYAADAYNLDAVDYVVKPVEDARLSKALDKIE 120
Cdd:PRK10046   81 VVFTTAASdmETVSEAVRCGVFDYLIKPIAYERLGQTLTRFR 122
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 8-106 1.98e-10

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 56.51  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   8 LVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLK----TPpvVV 82
Cdd:cd19937     1 LVVDDEEDIVELLKYNLEKE---GYeVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPktssIP--II 75

                          90       100
                  ....*....|....*....|....*.
gi 1469306671  83 FVTAFAEYAADAYNLD--AVDYVVKP 106
Cdd:cd19937    76 MLTAKGEEFDKVLGLElgADDYITKP 101
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
1-125 2.93e-10

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 58.33  E-value: 2.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   1 MSEG--WNILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIelaETLQNLKTP 78
Cdd:PRK10403    1 MPEAtpFQVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGL---DTLNALRRD 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1469306671  79 PVV--VFVTAFAEYAADAYNL---DAVDYVVKPVEDARLSKALDKIEAALGV 125
Cdd:PRK10403   78 GVTaqIIILTVSDASSDVFALidaGADGYLLKDSDPEVLLEAIRAGAKGSKV 129
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 7-114 1.33e-09

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 56.73  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELR-YL-LEKDTRVGHIAEAGNvtEAVESILSNKPDVLFLDITMPGRSGIELAETLQN--LKTPPVVV 82
Cdd:TIGR02875   5 IVIADDNKEFCNLLKeYLaAQPDMEVVGVAHNGV--DALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEieLSARPRVI 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1469306671  83 FVTAFAE--YAADAYNLDAVDYVVKPVEDARLSK 114
Cdd:TIGR02875  83 MLSAFGQekITQRAVALGADYYVLKPFDLEILAA 116
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 7-106 1.44e-09

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 54.35  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNvtEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGR--EALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTAK 78

                          90       100
                  ....*....|....*....|.
gi 1469306671  87 FAEY-AADAYNLDAVDYVVKP 106
Cdd:cd17614    79 DSEVdKVLGLELGADDYVTKP 99
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 8-127 1.73e-09

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 54.15  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   8 LVVDDEPPIRAELRYLLEKDTRVghIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL--QNLKTPpvVVFVT 85
Cdd:cd17625     1 LVVEDEKDLSEAITKHLKKEGYT--VDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLreEGIETP--VLLLT 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1469306671  86 AFA--EYAADAYNLDAVDYVVKPVEDARLskaLDKIEAALgvRR 127
Cdd:cd17625    77 ALDavEDRVKGLDLGADDYLPKPFSLAEL---LARIRALL--RR 115
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
6-144 2.63e-09

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 56.43  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIelaETLQNL--KTPPVVVF 83
Cdd:PRK12555    2 RIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGV---EATRRImaERPCPILI 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1469306671  84 VTAFAEYAA----DAYNLDAVDYVVKPVEDARLSKA------LDKIEAA--LGVRRVIHAPRQPLRLTVDRGG 144
Cdd:PRK12555   79 VTSLTERNAsrvfEAMGAGALDAVDTPTLGIGAGLEeyaaelLAKIDQIgrLLGRRLAPAAAPAAASAAPFRT 151
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 7-112 2.66e-09

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 53.54  E-value: 2.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:cd17627     1 ILVVDDDRAVRESLRRSLRFE---GYEVEtAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLT 77

                          90       100
                  ....*....|....*....|....*....
gi 1469306671  86 AFAEYAADAYNLD--AVDYVVKPVEDARL 112
Cdd:cd17627    78 ARDSVSDRVAGLDagADDYLVKPFALEEL 106
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 7-106 2.95e-09

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 52.83  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL--QNLKTPpvVVF 83
Cdd:cd19935     1 ILVVEDEKKLAEYLKKGLTEE---GYAVDvAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLraAGKQTP--VLM 75

                          90       100
                  ....*....|....*....|....*
gi 1469306671  84 VTAFAEYAADAYNLD--AVDYVVKP 106
Cdd:cd19935    76 LTARDSVEDRVKGLDlgADDYLVKP 100
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 7-134 3.72e-09

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 53.26  E-value: 3.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEK-DTRVghiAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNL-KTPPVVVfV 84
Cdd:cd17549     1 VLLVDDDADVREALQQTLELaGFRV---RAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELdPDLPVIL-I 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1469306671  85 TAFA--EYAADAYNLDAVDYVVKPVEDARLskaLDKIEAALGVRRVIHAPRQ 134
Cdd:cd17549    77 TGHGdvPMAVEAMRAGAYDFLEKPFDPERL---LDVVRRALEKRRLVLENRR 125
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 1-135 6.05e-09

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 55.65  E-value: 6.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   1 MSEGwNILVVDDEPPIRaelrYLLEKD-TRVG-HIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL-QNLKT 77
Cdd:PRK10923    1 MQRG-IVWVVDDDSSIR----WVLERAlAGAGlTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIkQRHPM 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  78 PPVVVfVTAFAEY--AADAYNLDAVDYVVKPVEdarLSKALDKIEAALGVRRVIHAPRQP 135
Cdd:PRK10923   76 LPVII-MTAHSDLdaAVSAYQQGAFDYLPKPFD---IDEAVALVERAISHYQEQQQPRNI 131
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 6-120 6.21e-09

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 52.80  E-value: 6.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPpIRAEL-RYLLEKDTRVGHIAEAGNVTEAVEsILSN--------KPDVLFLDITMPGRSGIE-LAE--TLQ 73
Cdd:cd17557     1 TILLVEDNP-GDAELiQEAFKEAGVPNELHVVRDGEEALD-FLRGegeyadapRPDLILLDLNMPRMDGFEvLREikADP 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1469306671  74 NLKTPPVVVFVTAFAEyaAD---AYNLDAVDYVVKPVEDARLSKALDKIE 120
Cdd:cd17557    79 DLRRIPVVVLTTSDAE--EDierAYELGANSYIVKPVDFEEFVEAIRSLG 126
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 7-107 6.87e-09

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 51.89  E-value: 6.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtRVGHIA-EAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:cd17565     1 FYIVDDDKNIIKILSDIIEDD-DLGEVVgEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMIS 79

                          90       100
                  ....*....|....*....|....
gi 1469306671  86 --AFAEYAADAYNLDAVDYVVKPV 107
Cdd:cd17565    80 qvSDKEMIGKAYQAGIEFFINKPI 103
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 7-118 9.01e-09

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 52.17  E-value: 9.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRvgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd17553     3 ILIVDDQYGIRILLNEVFNKEGY--QTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTA 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1469306671  87 FAE--YAADAYNLDAVDYVVKPVEDARLSKALDK 118
Cdd:cd17553    81 YGEldMIQESKELGALTHFAKPFDIDEIRDAVKK 114
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 6-123 9.91e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 52.24  E-value: 9.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAEL-----RYLLEKDTRVgHIAE---AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKT 77
Cdd:cd17533     2 NIFILEDDKIQRVRLeeiieNILKIENIEY-VIELtgkTEELLEKIKERGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1469306671  78 PPVVVFVTAFAEYAADA--YNLDAVDYVVKPVEdarLSKALDKIEAAL 123
Cdd:cd17533    81 YAIIIFVTTHSEFAPLTfeYKVAALDFILKPLK---LEEFKKRIEECI 125
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 7-112 1.13e-08

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 51.94  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDT-RVGHiaeAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQN---LKTPPVVV 82
Cdd:cd17598     1 ILIVEDSPTQAEQLKHILEEQGyKVQV---ARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSdpdLKDIPVIL 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1469306671  83 fVTAFA---------EYAADaynldavDYVVKPVEDARL 112
Cdd:cd17598    78 -LTTLSdprdvirglECGAD-------NFITKPYDEKYL 108
PRK10610 PRK10610
chemotaxis protein CheY;
8-125 1.37e-08

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 51.90  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   8 LVVDDEPPIRAELRYLLeKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQN---LKTPPVVVfV 84
Cdd:PRK10610    9 LVVDDFSTMRRIVRNLL-KELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRAdgaMSALPVLM-V 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1469306671  85 TAFA--EYAADAYNLDAVDYVVKPVEDARLSKALDKIEAALGV 125
Cdd:PRK10610   87 TAEAkkENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKLGM 129
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 6-108 1.53e-08

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 51.23  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPvVVFV 84
Cdd:cd17619     2 HILIVEDEPVTRATLKSYFEQE---GYdVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVG-IILV 77

                          90       100
                  ....*....|....*....|....*.
gi 1469306671  85 TAFAEYAADAYNLD--AVDYVVKPVE 108
Cdd:cd17619    78 TGRDDEVDRIVGLEigADDYVTKPFN 103
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 6-118 2.74e-08

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 50.86  E-value: 2.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRvgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELaetLQNLKT--PPVVVF 83
Cdd:cd17569     2 TILLVDDEPNILKALKRLLRREGY--EVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAEL---LKRVREryPDTVRI 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1469306671  84 V-TAFA--EYAADAYNLDAVD-YVVKPVEDARLSKALDK 118
Cdd:cd17569    77 LlTGYAdlDAAIEAINEGEIYrFLTKPWDDEELKETIRQ 115
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 33-106 2.99e-08

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 50.30  E-value: 2.99e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1469306671  33 IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQ--NLKTPPVVVFVTAFA--EYAADAYNLDAVDYVVKP 106
Cdd:cd17561    30 VGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRrmRLEKRPKIIMLTAFGqeDITQRAVELGASYYILKP 107
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 7-100 6.57e-08

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 49.42  E-value: 6.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtRVGHIAEAGNVTEAVESILSNKP-DVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:cd18160     2 ILLADDEPSVRKFIVTTLKK--AGYAVTEAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKIDPDVKILFIS 79

                          90
                  ....*....|....*
gi 1469306671  86 AFAEyAADAYNLDAV 100
Cdd:cd18160    80 GGAA-AAPELLSDAV 93
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 7-123 6.74e-08

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 49.58  E-value: 6.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRaelrYLLEKD-TRVGHIAEA-GNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNlKTP--PVVV 82
Cdd:cd19919     3 VWIVDDDSSIR----WVLERAlAGAGLTVTSfENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQ-RHPdlPVII 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1469306671  83 fVTAFA--EYAADAYNLDAVDYVVKPVEdarLSKALDKIEAAL 123
Cdd:cd19919    78 -MTAHSdlDSAVSAYQGGAFEYLPKPFD---IDEAVALVERAI 116
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 7-107 7.99e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 48.88  E-value: 7.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtrVGHIA-EAGNVTEAVESILSN-KPDVLFLDITMPGR-SGIELAETLQNLKTPPVVVF 83
Cdd:cd18161     1 VLVVEDDPDVRRLTAEVLED---LGYTVlEAASGDEALDLLESGpDIDLLVTDVIMPGGmNGSQLAEEARRRRPDLKVLL 77

                          90       100
                  ....*....|....*....|....*
gi 1469306671  84 VTAFAEYAADAYNLDA-VDYVVKPV 107
Cdd:cd18161    78 TSGYAENAIEGGDLAPgVDVLSKPF 102
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 7-106 8.14e-08

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 48.91  E-value: 8.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELR-YLLEKDTrvgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQ---NLKTPPvVV 82
Cdd:cd19927     1 ILLVDDDPGIRLAVKdYLEDQGF---TVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRknaDFDTIP-VI 76

                          90       100
                  ....*....|....*....|....*..
gi 1469306671  83 FVTAFAeYAAD---AYNLDAVDYVVKP 106
Cdd:cd19927    77 FLTAKG-MTSDrikGYNAGCDGYLSKP 102
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 7-106 9.32e-08

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 49.30  E-value: 9.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELR-YLLEKDTRVGHIAeagNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVfVT 85
Cdd:cd19938     2 ILIVEDEPKLAQLLIdYLRAAGYAPTLLA---HGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVPIIM-VT 77

                          90       100
                  ....*....|....*....|...
gi 1469306671  86 AFAEYAAD--AYNLDAVDYVVKP 106
Cdd:cd19938    78 ARVEEIDRllGLELGADDYICKP 100
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
7-112 1.02e-07

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 50.96  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGnvtEAVESILSNKPDVLFLDITMPGRSGIE-LAETLQNLKTPpvVVFVT 85
Cdd:PRK10955    4 ILLVDDDRELTSLLKELLEMEGFNVIVAHDG---EQALDLLDDSIDLLLLDVMMPKKNGIDtLKELRQTHQTP--VIMLT 78

                          90       100
                  ....*....|....*....|....*....
gi 1469306671  86 AFAEYAADAYNLD--AVDYVVKPVEDARL 112
Cdd:PRK10955   79 ARGSELDRVLGLElgADDYLPKPFNDREL 107
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 7-119 1.30e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 48.84  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtrVGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNL---KTPPVVV 82
Cdd:cd17562     3 ILAVDDSASIRQMVSFTLRG---AGYeVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKLpayKFTPILM 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1469306671  83 FVT-AFAEYAADAYNLDAVDYVVKPVEDARLSKALDKI 119
Cdd:cd17562    80 LTTeSSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKV 117
PRK10693 PRK10693
two-component system response regulator RssB;
34-116 1.96e-07

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 50.76  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  34 AEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQN--LKTPPVVVFVTAFAEYAADAYNLDAVDYVVKPVED-A 110
Cdd:PRK10693    1 VLAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNrgDQTPVLVISATENMADIAKALRLGVQDVLLKPVKDlN 80


                  ....*.
gi 1469306671 111 RLSKAL 116
Cdd:PRK10693   81 RLREMV 86
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 7-106 2.85e-07

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 47.53  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEK---DTRvghiaEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQN--LKTPpvV 81
Cdd:cd19926     1 VLVVDDEPDIRELLEITLGRmglDVR-----SARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQrlPQTP--V 73

                          90       100
                  ....*....|....*....|....*..
gi 1469306671  82 VFVTAF--AEYAADAYNLDAVDYVVKP 106
Cdd:cd19926    74 AVITAYgsLDTAIEALKAGAFDFLTKP 100
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 7-108 3.51e-07

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 47.75  E-value: 3.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPI-RAELRYLLEKDTRVGHIaeaGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPvVVFVT 85
Cdd:cd19939     2 ILIVEDELELaRLTRDYLIKAGLEVSVF---TDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHVP-ILMLT 77

                          90       100
                  ....*....|....*....|....*
gi 1469306671  86 AFAEYAAD--AYNLDAVDYVVKPVE 108
Cdd:cd19939    78 ARTEEMDRvlGLEMGADDYLCKPFS 102
PRK10766 PRK10766
two-component system response regulator TorR;
4-108 5.00e-07

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 48.88  E-value: 5.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   4 GWNILVVDDEPPIRAELRYLLEKDtrvGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVV 82
Cdd:PRK10766    2 SYHILVVEDEPVTRARLQGYFEQE---GYtVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIIL 78

                          90       100
                  ....*....|....*....|....*...
gi 1469306671  83 fVTAFAEYAADAYNLD--AVDYVVKPVE 108
Cdd:PRK10766   79 -VTGRTDSIDRIVGLEmgADDYVTKPLE 105
ompR PRK09468
osmolarity response regulator; Provisional
 1-135 6.82e-07

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 48.82  E-value: 6.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   1 MSEGWNILVVDDEPPIRAEL-RYLLEKDTRVGHIAEAgnvtEAVESILSNKP-DVLFLDITMPGRSGIELAETL--QNLK 76
Cdd:PRK09468    2 MQENYKILVVDDDMRLRALLeRYLTEQGFQVRSAANA----EQMDRLLTRESfHLMVLDLMLPGEDGLSICRRLrsQNNP 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1469306671  77 TPpvVVFVTAFAEYAADAYNLD--AVDYVVKPVEDARLskaLDKIEAALGvRRVIHAPRQP 135
Cdd:PRK09468   78 TP--IIMLTAKGEEVDRIVGLEigADDYLPKPFNPREL---LARIRAVLR-RQAPELPGAP 132
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 5-67 8.29e-07

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 46.98  E-value: 8.29e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1469306671   5 WNILVVDDEPPIRAELRYLLEKDTRVghiAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIE 67
Cdd:cd17596     1 PTILVVDDEVRSLEALRRTLEEDFDV---LTAASAEEALAILEEEWVQVILCDQRMPGTTGVE 60
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
7-129 8.47e-07

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 48.56  E-value: 8.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRvgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQN--LKTPPVVVFV 84
Cdd:PRK10161    5 ILVVEDEAPIREMVCFVLEQNGF--QPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKResMTRDIPVVML 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1469306671  85 TAFAEYAADAYNLD--AVDYVVKPVED----ARLSKALDKIeAALGVRRVI 129
Cdd:PRK10161   83 TARGEEEDRVRGLEtgADDYITKPFSPkelvARIKAVMRRI-SPMAVEEVI 132
orf27 CHL00148
Ycf27; Reviewed
 7-106 1.07e-06

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 48.17  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRaelRYLLEKDTRVG-HIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPvVVFVT 85
Cdd:CHL00148    9 ILVVDDEAYIR---KILETRLSIIGyEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVP-IIMLT 84

                          90       100
                  ....*....|....*....|...
gi 1469306671  86 AFAEYA--ADAYNLDAVDYVVKP 106
Cdd:CHL00148   85 ALGDVSdrITGLELGADDYVVKP 107
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
6-105 1.31e-06

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 47.56  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:PRK09935    5 SVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLS 84

                          90       100
                  ....*....|....*....|..
gi 1469306671  86 AFAE--YAADAYNLDAVDYVVK 105
Cdd:PRK09935   85 SKSEcfYAGRAIQAGANGFVSK 106
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 6-106 1.49e-06

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 47.65  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGnvTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:PRK11083    5 TILLVEDEQAIADTLVYALQSEGFTVEWFERG--LPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLT 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1469306671  86 AFA---------EYAADaynldavDYVVKP 106
Cdd:PRK11083   83 ARSdevdrlvglEIGAD-------DYVAKP 105
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 6-106 1.83e-06

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 47.49  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKD-TRVghiAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:PRK10529    3 NVLIVEDEQAIRRFLRTALEGDgMRV---FEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLS 79

                          90       100
                  ....*....|....*....|...
gi 1469306671  85 TAFAEY-AADAYNLDAVDYVVKP 106
Cdd:PRK10529   80 ARSEESdKIAALDAGADDYLSKP 102
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 7-106 2.56e-06

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 45.06  E-value: 2.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtrVGH-IAEAGNVTEAVESI---------LSNKPDVLFLDITMPGRSGIELAETLQN-- 74
Cdd:cd19924     1 ILVVDDSPTARKQLRDLLKN---LGFeIAEAVDGEEALNKLenlakegndLSKELDLIITDIEMPKMDGYELTFELRDdp 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1469306671  75 -LKTPPVVVFVTAFAEY-AADAYNLDAVDYVVKP 106
Cdd:cd19924    78 rLANIPVILNSSLSGEFsRARGKKVGADAYLAKF 111
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 7-112 2.79e-06

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 45.06  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEK---DTRVGHIAEAgnvteAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVF 83
Cdd:cd17622     3 ILLVEDDPKLARLIADFLEShgfNVVVEHRGDR-----ALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLL 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1469306671  84 vTAFAEYAADAYNLD--AVDYVVKPVEDARL 112
Cdd:cd17622    78 -TALDSDIDHILGLElgADDYVVKPVEPAVL 107
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 7-112 3.38e-06

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 44.77  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGnvTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVfVTA 86
Cdd:cd17626     3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDG--TQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVM-LTA 79

                          90       100
                  ....*....|....*....|....*...
gi 1469306671  87 FAEYAADAYNLD--AVDYVVKPVEDARL 112
Cdd:cd17626    80 KSDTVDVVLGLEsgADDYVAKPFKPKEL 107
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 7-106 3.39e-06

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 44.97  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEkdtRVGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL--QNLKTPpvVVF 83
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLS---DAGYVVDvAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWrsEGRATP--VLI 75

                          90       100
                  ....*....|....*....|....*
gi 1469306671  84 VTAFAEYAADAYNLD--AVDYVVKP 106
Cdd:cd19934    76 LTARDSWQDKVEGLDagADDYLTKP 100
PRK09483 PRK09483
response regulator; Provisional
 6-67 3.51e-06

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 46.64  E-value: 3.51e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIE 67
Cdd:PRK09483    3 NVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLE 64
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 7-106 3.64e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 44.50  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEAGnvTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDG--PAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSNVPVIMVTAK 78

                          90       100
                  ....*....|....*....|.
gi 1469306671  87 FAEY-AADAYNLDAVDYVVKP 106
Cdd:cd17621    79 DSEIdKVVGLELGADDYVTKP 99
PRK10430 PRK10430
two-component system response regulator DcuR;
6-116 3.92e-06

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 46.64  E-value: 3.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIrAEL-RYLLEKDTRVGHIAEAGNVTEAVESILSNKP--DVLFLDITMPGRSGIELAETLQNLKTPPVVV 82
Cdd:PRK10430    3 NVLIVDDDAMV-AELnRRYVAQIPGFQCCGTASTLEQAKEIIFNSDTpiDLILLDIYMQQENGLDLLPVLHEAGCKSDVI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1469306671  83 FVTAfaeyAADAYNLD------AVDYVVKPVEDARLSKAL 116
Cdd:PRK10430   82 VISS----AADAATIKdslhygVVDYLIKPFQASRFEEAL 117
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
6-118 4.42e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 46.95  E-value: 4.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKdtrVGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFV 84
Cdd:PRK10365    7 DILVVDDDISHCTILQALLRG---WGYnVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIM 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1469306671  85 TAFA--EYAADAYNLDAVDYVVKPVEDARLSKALDK 118
Cdd:PRK10365   84 TAYSsvETAVEALKTGALDYLIKPLDFDNLQATLEK 119
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 6-116 7.68e-06

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 46.38  E-value: 7.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPpirAELRY---LLEKdtRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGI----ELAETLQNLKTP 78
Cdd:PRK11107  669 TVMAVDDNP---ANLKLigaLLEE--QVEHVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIraceLIRQLPHNQNTP 743

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1469306671  79 pvVVFVTAFAeYAADAYNLDA---VDYVVKPVEDARLSKAL 116
Cdd:PRK11107  744 --IIAVTAHA-MAGERERLLSagmDDYLAKPIDEAMLKQVL 781
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 7-123 8.08e-06

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 43.81  E-value: 8.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVGHIAEagNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPvVVFVTA 86
Cdd:cd18159     1 ILIVEDDETIASLLKKHLEKWGYEVVLIE--DFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISNVP-IIFISS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1469306671  87 fAEYAAD---AYNLDAVDYVVKPVEdarLSKALDKIEAAL 123
Cdd:cd18159    78 -RDDNMDqvmAINMGGDDYITKPFD---LDVLLAKIKAIL 113
PRK09191 PRK09191
two-component response regulator; Provisional
 6-89 8.93e-06

two-component response regulator; Provisional


Pssm-ID: 236402 [Multi-domain]  Cd Length: 261  Bit Score: 45.61  E-value: 8.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEkdtRVGH--IAEAGNVTEAVESILSNKPDVLFLDITM-PGRSGIELA-ETLQNLKTPpvV 81
Cdd:PRK09191  139 RVLIIEDEPIIAMDLEQLVE---SLGHrvTGIARTRAEAVALAKKTRPGLILADIQLaDGSSGIDAVnDILKTFDVP--V 213


                  ....*...
gi 1469306671  82 VFVTAFAE 89
Cdd:PRK09191  214 IFITAFPE 221
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 7-106 1.17e-05

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 43.40  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdTRVGHIAEAGNVTEAVESILSNKPDVLFLDITM-PGRSGIELAETLQNLKTPP---VVV 82
Cdd:cd17589     1 FLIVDDQPTFRSMLKSMLRS-LGVTRIDTASSGEEALRMCENKTYDIVLCDYNLgKGKNGQQLLEELRHKKLISpstVFI 79

                          90       100
                  ....*....|....*....|....*.
gi 1469306671  83 FVTAFAEYAA--DAYNLDAVDYVVKP 106
Cdd:cd17589    80 MVTGESSRAMvlSALELEPDDYLLKP 105
pleD PRK09581
response regulator PleD; Reviewed
 7-112 1.29e-05

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 45.66  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDeppIRAELRyLLEkdTRVghIAE------AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAEtlqNLKTPPV 80
Cdd:PRK09581    5 ILVVDD---IPANVK-LLE--AKL--LAEyytvltASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCR---RLKSDPA 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1469306671  81 -----VVFVTAFA---------EYAADaynldavDYVVKPVEDARL 112
Cdd:PRK09581   74 tthipVVMVTALDdpedrvrglEAGAD-------DFLTKPINDVAL 112
PRK15369 PRK15369
two component system response regulator;
6-105 1.39e-05

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 44.68  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   6 NILVVDDEPPIRAELRYLLEKDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:PRK15369    5 KILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLT 84

                          90       100
                  ....*....|....*....|..
gi 1469306671  86 AFAE--YAADAYNLDAVDYVVK 105
Cdd:PRK15369   85 ARQEehMASRTLAAGALGYVLK 106
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 7-106 1.68e-05

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 43.11  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRvgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVTA 86
Cdd:cd17615     2 VLVVDDEPNITELLSMALRYEGW--DVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTA 79

                          90       100
                  ....*....|....*....|..
gi 1469306671  87 --FAEYAADAYNLDAVDYVVKP 106
Cdd:cd17615    80 kdSVEDRIAGLTAGGDDYVTKP 101
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 7-72 1.85e-05

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 42.89  E-value: 1.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtrvgH---IAEAGNVTEAVEsILSNKPDV--LFLDITMPGRSGIELAETL 72
Cdd:cd17544     3 VLVVDDSATSRNHLRALLRR-----HnfqVLEAANGQEALE-VLEQHPDIklVITDYNMPEMDGFELVREI 67
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 7-106 3.00e-05

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 43.91  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAEL-RYLLEKDTRVGHIAeagNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVfVT 85
Cdd:PRK10710   13 ILIVEDEPKLGQLLiDYLQAASYATTLLS---HGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVM-VT 88

                          90       100
                  ....*....|....*....|...
gi 1469306671  86 AFAEYAADAYNLD--AVDYVVKP 106
Cdd:PRK10710   89 AKIEEIDRLLGLEigADDYICKP 111
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 7-106 3.31e-05

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 41.66  E-value: 3.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEkdtrvghiAEAGNV------TEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPv 80
Cdd:cd19936     1 IALVDDDRNILTSVSMALE--------AEGFSVetytdgASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTLP- 71

                          90       100
                  ....*....|....*....|....*...
gi 1469306671  81 VVFVTAFAEYAADAYNL--DAVDYVVKP 106
Cdd:cd19936    72 VIFLTSKDDEIDEVFGLrmGADDYITKP 99
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 7-82 4.26e-05

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 41.59  E-value: 4.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDT-RVGHIAEAgnvTEAVESILSNKPDVLFLDITMPGRSGIELAETL---QNLKTPPVVV 82
Cdd:cd17602     1 VACVDDRPSIQKMIEYFLEKQGfRVVVIDDP---LRALTTLLNSKPDLILIDIDMPDLDGYELCSLLrksSALKDTPIIM 77
PRK13435 PRK13435
response regulator; Provisional
 7-135 7.85e-05

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 41.58  E-value: 7.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKdtrVGH--IAEAGNVTEAVESILSNKPDVLFLDIT-MPGRSGIELAETLQNLKTPPvVVF 83
Cdd:PRK13435    8 VLIVEDEALIALELEKLVEE---AGHevVGIAMSSEQAIALGRRRQPDVALVDVHlADGPTGVEVARRLSADGGVE-VVF 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1469306671  84 VTAFAEYAADAYNlDAVDYVVKPVEDARLSKALDKIEAalgvRRVIHAPRQP 135
Cdd:PRK13435   84 MTGNPERVPHDFA-GALGVIAKPYSPRGVARALSYLSA----RRVGDRASGP 130
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 7-116 9.44e-05

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 40.55  E-value: 9.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDtrvGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL--QNLKTPpvVVF 83
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRKA---GYAVDwVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWrrQGQSLP--VLI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1469306671  84 VTA---FAEYAAdAYNLDAVDYVVKPVE----DARLsKAL 116
Cdd:cd17624    76 LTArdgVDDRVA-GLDAGADDYLVKPFAleelLARL-RAL 113
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 7-116 9.96e-05

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 40.53  E-value: 9.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEkDTRVGHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPpvVVFVTA 86
Cdd:cd17586     1 VLVLEDEPLIAMNLEDALE-DLGGKEVVTAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRRAIP--FIFATG 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1469306671  87 FAEYAADAYNLDAVDYVVKPVEDARLSKAL 116
Cdd:cd17586    78 YGDSHGIDSRLIDVPVLRKPFDADSALAAL 107
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 7-107 1.94e-04

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 39.92  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLekdTRVG-HIAEAGNVTEAVESILSNKP--DVLFLDITMPGRSGIELAETLQNLKTPPVVVF 83
Cdd:cd17584     1 VLVVDDDPTCLAILKRML---LRCGyQVTTCTDAEEALSMLRENKDefDLVITDVHMPDMDGFEFLELIRLEMDLPVIMM 77

                          90       100
                  ....*....|....*....|....*
gi 1469306671  84 VTAFAEYAA-DAYNLDAVDYVVKPV 107
Cdd:cd17584    78 SADGSTSTVmKGLAHGACDYLLKPV 102
PRK13557 PRK13557
histidine kinase; Provisional
 7-132 2.85e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 41.58  E-value: 2.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIrAEL-RYLLEKDTRVGHIAEagNVTEAVESILSN-KPDVLFLDITMPG-RSGIELA----ETLQNLKtpp 79
Cdd:PRK13557  418 ILIVDDRPDV-AELaRMILEDFGYRTLVAS--NGREALEILDSHpEVDLLFTDLIMPGgMNGVMLArearRRQPKIK--- 491

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1469306671  80 vVVFVTAFAEYAADAYNLDAVDYVVkpvedarLSKALDKIEAALGVRRVIHAP 132
Cdd:PRK13557  492 -VLLTTGYAEASIERTDAGGSEFDI-------LNKPYRRAELARRVRMVLDGP 536
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 7-112 3.27e-04

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 39.21  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKD---TRVGHIAEAGnvteaVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVf 83
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEMEgfnVRAAHDGEQG-----LAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLM- 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1469306671  84 VTAFAEYAADAYNLD--AVDYVVKPVEDARL 112
Cdd:cd17623    75 LTARGDDIDRILGLElgADDYLPKPFNPREL 105
LivK COG0683
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid ...
 38-149 3.79e-04

ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid transport and metabolism];


Pssm-ID: 440447 [Multi-domain]  Cd Length: 314  Bit Score: 41.07  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671  38 NVTEAVESILSNKPDVLFLdiTMPGRSGIELAETL--QNLKTPPVVVFVTAFAE--------YAADAYnlDAVDYVVKPV 107
Cdd:COG0683   184 DFSAQLTKIKAAGPDAVFL--AGYGGDAALFIKQAreAGLKGPLNKAFVKAYKAkygrepssYAAAGY--DAALLLAEAI 259

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1469306671 108 EDARlSKALDKIEAAL------GVRRVI-----HAPRQPLRL-TVDRGGKKVFI 149
Cdd:COG0683   260 EKAG-STDREAVRDALeglkfdGVTGPItfdpdGQGVQPVYIvQVKADGKFVVV 312
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 7-105 5.50e-04

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 38.93  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAELRYLLEKDTRVG-HIAEagNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL----QNLKTPPVV 81
Cdd:cd17575     3 VLLVDDQAIIGEAVRRALADEEDIDfHYCS--DPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFranpATRDIPIIV 80

                          90       100
                  ....*....|....*....|....
gi 1469306671  82 VFVTAFAEYAADAYNLDAVDYVVK 105
Cdd:cd17575    81 LSTKEEPEVKSEAFALGANDYLVK 104
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 7-141 6.00e-04

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 40.00  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIrAEL--RYLLEKDTRVghIAEA-GNVTEAVesILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVF 83
Cdd:PRK10701    4 IVFVEDDAEV-GSLiaAYLAKHDIDV--TVEPrGDRAEAT--ILREQPDLVLLDIMLPGKDGMTICRDLRPKWQGPIVLL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1469306671  84 VTafaeYAAD-----AYNLDAVDYVVK----PVEDARLSKALDKIEAALGVRRVIHAPRQPLR------LTVD 141
Cdd:PRK10701   79 TS----LDSDmnhilALEMGACDYILKttppAVLLARLRLHLRQNEQATQTKGLQETSLTPYKalhfgtLTID 147
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 7-112 1.23e-03

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 37.43  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRAEL-RYLLEKDTRVghiAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVfVT 85
Cdd:cd17594     2 VLVVDDDAAMRHLLiLYLRERGFDV---TAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIII-IS 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1469306671  86 AFAEYAAD---AYNLDAVDYVVKPVEDARL 112
Cdd:cd17594    78 GDRRDEIDrvvGLELGADDYLAKPFGLREL 107
PRK11173 PRK11173
two-component response regulator; Provisional
 6-72 1.41e-03

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 38.84  E-value: 1.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1469306671   6 NILVVDDEPPIRAELRYLLEkdtrvghiAEAGNVTEAVE-----SILSNKP-DVLFLDITMPGRSGIELAETL 72
Cdd:PRK11173    5 HILIVEDELVTRNTLKSIFE--------AEGYDVFEATDgaemhQILSENDiNLVIMDINLPGKNGLLLAREL 69
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
 7-106 1.90e-03

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 37.32  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPI-RA---ELRYLLEKDTRVghiAEAGNVTEAVESI----LSNKPDVLFL-DITMPGRSGIELAETLQNLKT 77
Cdd:cd17595     3 ILTVDDDPQVlRAvarDLRRQYGKDYRV---LRADSGAEALDALkelkLRGEAVALFLvDQRMPEMDGVEFLEKAMELFP 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1469306671  78 PPVVVFVTAFA--EYAADAYNLDAVD-YVVKP 106
Cdd:cd17595    80 EAKRVLLTAYAdtDAAIRAINDVQLDyYLLKP 111
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 7-154 3.07e-03

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 38.67  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEP---PIRAELryllEKDTRVgHIAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL-QNLKTPPVVV 82
Cdd:PRK13558   10 VLFVGDDPeagPVDCDL----DEDGRL-DVTQIRDFVAARDRVEAGEIDCVVADHEPDGFDGLALLEAVrQTTAVPPVVV 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1469306671  83 FVTAFAEYAA-DAYNLDAVDYVVKPVEDArLSKALDKIEAALGVRRVIHAPRQP---LRLTVDRGGKKVFIPAADV 154
Cdd:PRK13558   85 VPTAGDEAVArRAVDADAAAYVPAVSDDA-TAAIAERIESAVPEHSRDTEARMPisdLTVESDRRLKERALDEAPV 159
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 7-147 6.35e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 36.83  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEppiRAELRYLLEKDTRVGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNLKTPPVVVFVT 85
Cdd:PRK09836    3 LLIVEDE---KKTGEYLTKGLTEAGFVVDlADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLT 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1469306671  86 AFA--EYAADAYNLDAVDYVVKPVEDARLskaLDKIEAAL--GVRRVIHAPRQPLRLTVDRGGKKV 147
Cdd:PRK09836   80 ALGtiEHRVKGLELGADDYLVKPFAFAEL---LARVRTLLrrGAAVIIESQFQVADLMVDLVSRKV 142
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
7-89 7.28e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 37.26  E-value: 7.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPPIRaelRYLLEKDTRVGH-IAEAGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETLQNL-KTPPVV-VF 83
Cdd:PRK10841  804 ILVVDDHPINR---RLLADQLGSLGYqCKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLgLTLPVIgVT 880


                  ....*.
gi 1469306671  84 VTAFAE 89
Cdd:PRK10841  881 ANALAE 886
PRK15479 PRK15479
transcriptional regulator TctD;
7-112 7.95e-03

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 36.62  E-value: 7.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306671   7 ILVVDDEPpiraELRYLLEKD-TRVGHIAE-AGNVTEAVESILSNKPDVLFLDITMPGRSGIELAETL----QNLKtppv 80
Cdd:PRK15479    3 LLLAEDNR----ELAHWLEKAlVQNGFAVDcVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLrkrgQTLP---- 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1469306671  81 VVFVTAFAEYA--ADAYNLDAVDYVVKPVE----DARL 112
Cdd:PRK15479   75 VLLLTARSAVAdrVKGLNVGADDYLPKPFEleelDARL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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