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Conserved domains on  [gi|1518618031|ref|WP_123466739|]
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hemopexin repeat-containing protein [Streptomyces sp. CEV 2-1]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX super family cl02471
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 5-200 1.54e-28

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


The actual alignment was detected with superfamily member cd00094:

Pssm-ID: 413329 [Multi-domain]  Cd Length: 194  Bit Score: 110.48  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518618031   5 TAFFFRGGTYVRYDVNpstgidtvDTGSYPRDIGAGWDAMPvsfrNNIDAAVTWPDA-FVYFFKGSTYvrWdATDDTVDA 83
Cdd:cd00094    18 ELYFFKGRYFWRLSPG--------KPPGSPFLISSFWPSLP----SPVDAAFERPDTgKIYFFKGDKY--W-VYTGKNLE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518618031  84 SNYPRDIAE-GWTAFPasfrTGIDAAINWGD-GYAYFFKGPKYIKYNIGNDTVDASvYPRDTAEGWTAFPasfrTGIDAA 161
Cdd:cd00094    83 PGYPKPISDlGFPPTV----KQIDAALRWPDnGKTYFFKGDKYWRYDEKTQKMDPG-YPKLIETDFPGVP----DKVDAA 153

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1518618031 162 INWGDGYAYFFKGPKYIKYNIGNDTVDaSVYPRDTAEGW 200
Cdd:cd00094   154 FRWLDGYYYFFKGDQYWRFDPRSKEVR-VGYPLKISSDW 191
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 5-200 1.54e-28

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 110.48  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518618031   5 TAFFFRGGTYVRYDVNpstgidtvDTGSYPRDIGAGWDAMPvsfrNNIDAAVTWPDA-FVYFFKGSTYvrWdATDDTVDA 83
Cdd:cd00094    18 ELYFFKGRYFWRLSPG--------KPPGSPFLISSFWPSLP----SPVDAAFERPDTgKIYFFKGDKY--W-VYTGKNLE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518618031  84 SNYPRDIAE-GWTAFPasfrTGIDAAINWGD-GYAYFFKGPKYIKYNIGNDTVDASvYPRDTAEGWTAFPasfrTGIDAA 161
Cdd:cd00094    83 PGYPKPISDlGFPPTV----KQIDAALRWPDnGKTYFFKGDKYWRYDEKTQKMDPG-YPKLIETDFPGVP----DKVDAA 153

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1518618031 162 INWGDGYAYFFKGPKYIKYNIGNDTVDaSVYPRDTAEGW 200
Cdd:cd00094   154 FRWLDGYYYFFKGDQYWRFDPRSKEVR-VGYPLKISSDW 191
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 52-98 1.73e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.46  E-value: 1.73e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1518618031   52 IDAAVTWPDAFVYFFKGSTYVRWDatDDTVDaSNYPRDIAEGWTAFP 98
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFD--PKRVD-PGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 105-128 1.71e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....
gi 1518618031 105 IDAAINWGDGYAYFFKGPKYIKYN 128
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFD 24
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 5-200 1.54e-28

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 110.48  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518618031   5 TAFFFRGGTYVRYDVNpstgidtvDTGSYPRDIGAGWDAMPvsfrNNIDAAVTWPDA-FVYFFKGSTYvrWdATDDTVDA 83
Cdd:cd00094    18 ELYFFKGRYFWRLSPG--------KPPGSPFLISSFWPSLP----SPVDAAFERPDTgKIYFFKGDKY--W-VYTGKNLE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518618031  84 SNYPRDIAE-GWTAFPasfrTGIDAAINWGD-GYAYFFKGPKYIKYNIGNDTVDASvYPRDTAEGWTAFPasfrTGIDAA 161
Cdd:cd00094    83 PGYPKPISDlGFPPTV----KQIDAALRWPDnGKTYFFKGDKYWRYDEKTQKMDPG-YPKLIETDFPGVP----DKVDAA 153

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1518618031 162 INWGDGYAYFFKGPKYIKYNIGNDTVDaSVYPRDTAEGW 200
Cdd:cd00094   154 FRWLDGYYYFFKGDQYWRFDPRSKEVR-VGYPLKISSDW 191
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 52-98 1.73e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.46  E-value: 1.73e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1518618031   52 IDAAVTWPDAFVYFFKGSTYVRWDatDDTVDaSNYPRDIAEGWTAFP 98
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFD--PKRVD-PGYPKLISSFFPGLP 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 105-151 3.91e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 40.69  E-value: 3.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1518618031  105 IDAAINWGDGYAYFFKGPKYIKYNigNDTVDaSVYPRDTAEGWTAFP 151
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFD--PKRVD-PGYPKLISSFFPGLP 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 158-203 1.61e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 38.76  E-value: 1.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1518618031  158 IDAAINWGDGYAYFFKGPKYIKYNigNDTVDaSVYPRDTAEGWTQL 203
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFD--PKRVD-PGYPKLISSFFPGL 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 105-128 1.71e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....
gi 1518618031 105 IDAAINWGDGYAYFFKGPKYIKYN 128
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFD 24
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 158-181 1.71e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....
gi 1518618031 158 IDAAINWGDGYAYFFKGPKYIKYN 181
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFD 24
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 52-92 5.43e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.46  E-value: 5.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1518618031  52 IDAAVTWPDAFVYFFKGSTYVRwdaTDDTVDASNYPRDIAE 92
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWR---FDPQRVEPGYPKLISD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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