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Conserved domains on  [gi|1777560448|ref|WP_154254045|]
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MULTISPECIES: ATP-binding protein [Bacillota]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 21-283 8.82e-86

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member PRK08116:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 268  Bit Score: 257.64  E-value: 8.82e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  21 SKDEENRSYidqETGLKYCAKCKTPIEKEIDFFGEIKKVGILCQCKKERQKLEEEKRKENKRLLKIEHLKKECFSDPILL 100
Cdd:PRK08116    4 SVDTEADSE---EDGGEYCEVCGKRIEKVVELLGKNRIVPIMCECEREAEEAKEREEENREKQRRIERLKSNSLLDEKFR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 101 NWNFKNMDKDSEHEK---VAKNYVEKFDEIYENNIGLILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTN- 176
Cdd:PRK08116   81 NSTFENFLFDKGSEKaykIARKYVKKFEEMKKENVGLLLWGSVGTGKTYLAACIANELIEKGVPVIFVNFPQLLNRIKSt 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 177 ----FEIDKSKYIDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIDSRYRSGKPLIITTNLNISALTNPetiKDKRIYSRI 252
Cdd:PRK08116  161 ykssGKEDENEIIRSLVNADLLILDDLGAERDTEWAREKVYNIIDSRYRKGLPTIVTTNLSLEELKNQ---YGKRIYDRI 237

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1777560448 253 LEICSPIIFTGENRRIEKMKEKSKLAYEILK 283
Cdd:PRK08116  238 LEMCTPVENEGKSYRKEIAKEKLQRLKELLK 268
 
Name Accession Description Interval E-value
PRK08116 PRK08116
hypothetical protein; Validated
 21-283 8.82e-86

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 257.64  E-value: 8.82e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  21 SKDEENRSYidqETGLKYCAKCKTPIEKEIDFFGEIKKVGILCQCKKERQKLEEEKRKENKRLLKIEHLKKECFSDPILL 100
Cdd:PRK08116    4 SVDTEADSE---EDGGEYCEVCGKRIEKVVELLGKNRIVPIMCECEREAEEAKEREEENREKQRRIERLKSNSLLDEKFR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 101 NWNFKNMDKDSEHEK---VAKNYVEKFDEIYENNIGLILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTN- 176
Cdd:PRK08116   81 NSTFENFLFDKGSEKaykIARKYVKKFEEMKKENVGLLLWGSVGTGKTYLAACIANELIEKGVPVIFVNFPQLLNRIKSt 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 177 ----FEIDKSKYIDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIDSRYRSGKPLIITTNLNISALTNPetiKDKRIYSRI 252
Cdd:PRK08116  161 ykssGKEDENEIIRSLVNADLLILDDLGAERDTEWAREKVYNIIDSRYRKGLPTIVTTNLSLEELKNQ---YGKRIYDRI 237

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1777560448 253 LEICSPIIFTGENRRIEKMKEKSKLAYEILK 283
Cdd:PRK08116  238 LEMCTPVENEGKSYRKEIAKEKLQRLKELLK 268
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
65-267 1.53e-28

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 109.48  E-value: 1.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  65 CKKErqkLEEEKRKENKRLLKIEHLKKE-CFSDpilLNWNF-KNMDKDSEHEKVAKNYVEKfdeiYENnigLILTGNVGC 142
Cdd:COG1484    44 LEAE---VAEREQRRIERRLKAARFPAAkTLED---FDFDAqPGLDRRQILELATLDFIER----GEN---LILLGPPGT 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 143 GKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKS--KYIDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIDSRY 220
Cdd:COG1484   111 GKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRleRLLKRLAKVDLLILDELGYLPLDAEGAELLFELISDRY 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1777560448 221 RsGKPLIITTNLNISALTnpETIKDK----RIYSRILEICSPIIFTGENRR 267
Cdd:COG1484   191 E-RRSTIITSNLPFSEWG--EVFGDPtlatAILDRLVHHAHIIELKGESYR 238
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 134-235 1.89e-17

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 79.44  E-value: 1.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 134 LILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKS--KYIDNLNHKKLLIIDDFGMERDTDFAAEH 211
Cdd:NF038214   93 VLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADGRlgRLLRRLARYDLLIIDELGYLPFSREGANL 172

                          90       100
                  ....*....|....*....|....*.
gi 1777560448 212 IFNIIDSRY--RSgkpLIITTNLNIS 235
Cdd:NF038214  173 LFELIADRYerGS---TIITSNLPFS 195
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 133-255 4.31e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.07  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 133 GLILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKSKYIDNLNHKK------LLIIDDFG-MERDT 205
Cdd:cd00009    21 NLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAekakpgVLFIDEIDsLSRGA 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1777560448 206 DFAAEHIFNIIDSRY--RSGKPLIITTNLnisaltNPETIKDKRIYSRILEI 255
Cdd:cd00009   101 QNALLRVLETLNDLRidRENVRVIGATNR------PLLGDLDRALYDRLDIR 146
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 129-276 3.28e-07

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 50.14  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 129 ENNIGLILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEiDKSKYIDNLN---HKKLLIIDDFGMERDT 205
Cdd:pfam01695  90 DRAQNVVLLGPPGVGKTHLAIALGVEACRAGYSVRFTSAADLVNQLKRAH-GDGKLTRKLQqllKPDVLILDEWGYLPLD 168

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1777560448 206 DFAAEHIFNIIDSRYRSGkPLIITTNLNI---SALTNPETIKDKrIYSRILEICSPIIFTGENRRiekMKEKSK 276
Cdd:pfam01695 169 QAEANLLFQVISKRYEHR-SIILTSNLPFgewGQVFGDAVLATA-ILDRLLHHCHIVPIKGESYR---LKTKSE 237
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 134-248 1.42e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 44.29  E-value: 1.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  134 LILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKSKYIDNL-----------------NHKKLLII 196
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKAsgsgelrlrlalalarkLKPDVLIL 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1777560448  197 DDFGMERDTDFAAEHIFNIidsRYRSGKPLIITTNLNISALTNPETIKDKRI 248
Cdd:smart00382  85 DEITSLLDAEQEALLLLLE---ELRLLLLLKSEKNLTVILTTNDEKDLGPAL 133
 
Name Accession Description Interval E-value
PRK08116 PRK08116
hypothetical protein; Validated
 21-283 8.82e-86

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 257.64  E-value: 8.82e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  21 SKDEENRSYidqETGLKYCAKCKTPIEKEIDFFGEIKKVGILCQCKKERQKLEEEKRKENKRLLKIEHLKKECFSDPILL 100
Cdd:PRK08116    4 SVDTEADSE---EDGGEYCEVCGKRIEKVVELLGKNRIVPIMCECEREAEEAKEREEENREKQRRIERLKSNSLLDEKFR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 101 NWNFKNMDKDSEHEK---VAKNYVEKFDEIYENNIGLILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTN- 176
Cdd:PRK08116   81 NSTFENFLFDKGSEKaykIARKYVKKFEEMKKENVGLLLWGSVGTGKTYLAACIANELIEKGVPVIFVNFPQLLNRIKSt 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 177 ----FEIDKSKYIDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIDSRYRSGKPLIITTNLNISALTNPetiKDKRIYSRI 252
Cdd:PRK08116  161 ykssGKEDENEIIRSLVNADLLILDDLGAERDTEWAREKVYNIIDSRYRKGLPTIVTTNLSLEELKNQ---YGKRIYDRI 237

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1777560448 253 LEICSPIIFTGENRRIEKMKEKSKLAYEILK 283
Cdd:PRK08116  238 LEMCTPVENEGKSYRKEIAKEKLQRLKELLK 268
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
65-267 1.53e-28

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 109.48  E-value: 1.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  65 CKKErqkLEEEKRKENKRLLKIEHLKKE-CFSDpilLNWNF-KNMDKDSEHEKVAKNYVEKfdeiYENnigLILTGNVGC 142
Cdd:COG1484    44 LEAE---VAEREQRRIERRLKAARFPAAkTLED---FDFDAqPGLDRRQILELATLDFIER----GEN---LILLGPPGT 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 143 GKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKS--KYIDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIDSRY 220
Cdd:COG1484   111 GKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRleRLLKRLAKVDLLILDELGYLPLDAEGAELLFELISDRY 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1777560448 221 RsGKPLIITTNLNISALTnpETIKDK----RIYSRILEICSPIIFTGENRR 267
Cdd:COG1484   191 E-RRSTIITSNLPFSEWG--EVFGDPtlatAILDRLVHHAHIIELKGESYR 238
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 105-274 1.11e-23

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 98.05  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 105 KNMDKDSEhekVAKNYVEKFDEIYENnigLILTGNVGCGKTYFASAIANALLEKEISV-KMTNFSVI----LNDMTNFEI 179
Cdd:PRK06835  163 KNMEKILE---KCKNFIENFDKNNEN---LLFYGNTGTGKTFLSNCIAKELLDRGKSViYRTADELIeilrEIRFNNDKE 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 180 DKSKYiDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIDSRYRSGKPLIITTNLNISALTNpetIKDKRIYSRILEICSPI 259
Cdd:PRK06835  237 LEEVY-DLLINCDLLIIDDLGTEKITEFSKSELFNLINKRLLRQKKMIISTNLSLEELLK---TYSERISSRLLGNFTLL 312

                         170
                  ....*....|....*
gi 1777560448 260 IFTGENRRIEKMKEK 274
Cdd:PRK06835  313 KFYGEDIRIKKNLQK 327
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 134-235 1.89e-17

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 79.44  E-value: 1.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 134 LILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKS--KYIDNLNHKKLLIIDDFGMERDTDFAAEH 211
Cdd:NF038214   93 VLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADGRlgRLLRRLARYDLLIIDELGYLPFSREGANL 172

                          90       100
                  ....*....|....*....|....*.
gi 1777560448 212 IFNIIDSRY--RSgkpLIITTNLNIS 235
Cdd:NF038214  173 LFELIADRYerGS---TIITSNLPFS 195
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 69-267 1.31e-16

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 77.99  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  69 RQKLEEEKRKENKRLLKIEHLKKEcfsdpiLLNWNFKNMDKDSEHEKVAKNYVEKFDEIYENNI---GLILTGNVGCGKT 145
Cdd:PRK08939   97 PEKIEADEEKAIKKRIQSIYMPKD------LLQASLADIDLDDRDRLDALMAALDFLEAYPPGEkvkGLYLYGDFGVGKS 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 146 YFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKS--KYIDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIdSRYR-- 221
Cdd:PRK08939  171 YLLAAIANELAKKGVSSTLLHFPEFIRELKNSISDGSvkEKIDAVKEAPVLMLDDIGAEQMSSWVRDEVLGVI-LQYRmq 249

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1777560448 222 SGKPLIITTNLNISALT---------NPETIKDKRIYSRILEICSPIIFTGENRR 267
Cdd:PRK08939  250 EELPTFFTSNFDFDELEhhlaytqrgEDETWKAARIMERIRYLAKEVHLEGKNRR 304
PRK06921 PRK06921
hypothetical protein; Provisional
 1-272 6.33e-14

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 70.19  E-value: 6.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448   1 MELIKEILEQKIKNAETNSPSKDEEnrsYIDqetglkyCAKCKtpiekeiDFFGEIKKVGIL-----CQCKKERQKleee 75
Cdd:PRK06921    7 EEKAAELLMRERPSTTTKPEESDAE---RYD-------CPKCK-------DRGIIIYRRNTAevwrqCECVEQRKI---- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  76 krkenKRLLKIEHLKKEcfsdpiLLNWNFKNMDKDSEHEKV------AKNYVEKFDEIYEN-NIGLILTGNVGCGKTYFA 148
Cdd:PRK06921   66 -----ERLLKASEITEA------FRKLTFKNFKTEGKPQAIkdayecAVEYVKDFEKIQESrKNSIALLGQPGSGKTHLL 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 149 SAIANALLEKE-ISVKMTNFSVILNDMTN-FEIDKSKyIDNLNHKKLLIIDDF-----GMERDTDFAAEHIFNIIDSRYR 221
Cdd:PRK06921  135 TAAANELMRKKgVPVLYFPFVEGFGDLKDdFDLLEAK-LNRMKKVEVLFIDDLfkpvnGKPRATEWQIEQMYSVLNYRYL 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1777560448 222 SGKPLIITTNLNISALTNpetiKDKRIYSRILEICSP--IIFTGE----NRRIEKMK 272
Cdd:PRK06921  214 NHKPILISSELTIDELLD----IDEALGSRIVEMCKDylVIIKGDsfelNHRLEGER 266
PRK07952 PRK07952
DNA replication protein DnaC; Validated
 67-239 4.83e-13

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 67.10  E-value: 4.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  67 KERQKLEEEKRKENKRLLKIEHLKKECFSDPILLNWNFKNMDKDSEHEKVAKNYVEKFDEIYENNIG-LILTGNVGCGKT 145
Cdd:PRK07952   34 KEQGRIRSAALERENRAMKMQRTFNRSGIRPLHQNCSFENYRVECEGQMNALSKARQYVEEFDGNIAsFIFSGKPGTGKN 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 146 YFASAIANALLEKEISVKMTNFSVILNDM----TNFEIDKSKYIDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIDSRYR 221
Cdd:PRK07952  114 HLAAAICNELLLRGKSVLIITVADIMSAMkdtfSNSETSEEQLLNDLSNVDLLVIDEIGVQTESRYEKVIINQIVDRRSS 193

                         170
                  ....*....|....*...
gi 1777560448 222 SGKPLIITTNLNISALTN 239
Cdd:PRK07952  194 SKRPTGMLTNSNMEEMTK 211
PRK12377 PRK12377
putative replication protein; Provisional
 68-252 1.78e-11

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 62.93  E-value: 1.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  68 ERQKLEEEKRKENKRLlKIEHLKKECFSDPILLNWNFKNMDKDSEHEK----VAKNYVEKFDEIYENnigLILTGNVGCG 143
Cdd:PRK12377   38 EGRKRSEEINRQNQQL-RVEKILNRSGIQPLHRKCSFANYQVQNDGQRyalsQAKSIADELMTGCTN---FVFSGKPGTG 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 144 KTYFASAIANALLEKEISVKMTNFS-VILNDMTNFEIDKS--KYIDNLNHKKLLIIDDFGMERDTDFAAEHIFNIIDSRY 220
Cdd:PRK12377  114 KNHLAAAIGNRLLAKGRSVIVVTVPdVMSRLHESYDNGQSgeKFLQELCKVDLLVLDEIGIQRETKNEQVVLNQIIDRRT 193

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1777560448 221 RSGKPLIITTNLNISALTnpeTIKDKRIYSRI 252
Cdd:PRK12377  194 ASMRSVGMLTNLNHEAMS---TLLGERVMDRM 222
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 133-255 4.31e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.07  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 133 GLILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKSKYIDNLNHKK------LLIIDDFG-MERDT 205
Cdd:cd00009    21 NLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAekakpgVLFIDEIDsLSRGA 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1777560448 206 DFAAEHIFNIIDSRY--RSGKPLIITTNLnisaltNPETIKDKRIYSRILEI 255
Cdd:cd00009   101 QNALLRVLETLNDLRidRENVRVIGATNR------PLLGDLDRALYDRLDIR 146
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 129-276 3.28e-07

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 50.14  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 129 ENNIGLILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEiDKSKYIDNLN---HKKLLIIDDFGMERDT 205
Cdd:pfam01695  90 DRAQNVVLLGPPGVGKTHLAIALGVEACRAGYSVRFTSAADLVNQLKRAH-GDGKLTRKLQqllKPDVLILDEWGYLPLD 168

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1777560448 206 DFAAEHIFNIIDSRYRSGkPLIITTNLNI---SALTNPETIKDKrIYSRILEICSPIIFTGENRRiekMKEKSK 276
Cdd:pfam01695 169 QAEANLLFQVISKRYEHR-SIILTSNLPFgewGQVFGDAVLATA-ILDRLLHHCHIVPIKGESYR---LKTKSE 237
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
134-229 1.12e-05

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 45.95  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 134 LILTGNVGCGKTYFASAIANALLEKEISVK---------MTNF--SVILNDMTNFeidKSKY--IDnlnhkkLLIIDDFG 200
Cdd:COG0593    37 LFLYGGVGLGKTHLLHAIGNEALENNPGARvvyltaeefTNDFinAIRNNTIEEF---KEKYrsVD------VLLIDDIQ 107

                          90       100
                  ....*....|....*....|....*....
gi 1777560448 201 MERDTDFAAEHIFNIIDSRYRSGKPLIIT 229
Cdd:COG0593   108 FLAGKEATQEEFFHTFNALREAGKQIVLT 136
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 134-248 1.42e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 44.29  E-value: 1.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448  134 LILTGNVGCGKTYFASAIANALLEKEISVKMTNFSVILNDMTNFEIDKSKYIDNL-----------------NHKKLLII 196
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKAsgsgelrlrlalalarkLKPDVLIL 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1777560448  197 DDFGMERDTDFAAEHIFNIidsRYRSGKPLIITTNLNISALTNPETIKDKRI 248
Cdd:smart00382  85 DEITSLLDAEQEALLLLLE---ELRLLLLLKSEKNLTVILTTNDEKDLGPAL 133
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 134-218 1.65e-05

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 42.98  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 134 LILTGNVGCGKTYFASAIANALLEKEisvKMTNFSVILNDMTnfeidkSKYIDNLNHKKLLIIDDFGMERDTDFAAEHIf 213
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARALLKKL---GLPKDSVYSRNPD------DDFWDGYTGQPVVIIDDFGQNPDGPDEAELI- 70


                  ....*
gi 1777560448 214 NIIDS 218
Cdd:pfam00910  71 RLVSS 75
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 133-155 4.84e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 41.05  E-value: 4.84e-04
                          10        20
                  ....*....|....*....|...
gi 1777560448 133 GLILTGNVGCGKTYFASAIANAL 155
Cdd:COG0464   193 GLLLYGPPGTGKTLLARALAGEL 215
dnaA PRK00149
chromosomal replication initiator protein DnaA;
134-229 4.01e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 38.19  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777560448 134 LILTGNVGCGKTYFASAIANALLEKEISVK---------MTNF--SVILNDMTNFeidKSKY--IDnlnhkkLLIIDDF- 199
Cdd:PRK00149  102 LFIYGGVGLGKTHLLHAIGNYILEKNPNAKvvyvtsekfTNDFvnALRNNTMEEF---KEKYrsVD------VLLIDDIq 172

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1777560448 200 ---GMERdtdfAAEHIFNIIDSRYRSGKPLIIT 229
Cdd:PRK00149  173 flaGKER----TQEEFFHTFNALHEAGKQIVLT 201
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 123-163 6.66e-03

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 36.64  E-value: 6.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1777560448 123 KFDEIYEN-----NIGLILTGNVGCGKTYFASAIANALLEKEISVK 163
Cdd:cd19526    14 KYPKIFASsplrlRSGILLYGPPGCGKTLLASAIASECGLNFISVK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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