Fibronectin type III protein; This domain family is found in bacteria and viruses, and is ...
475-615
1.41e-37
Fibronectin type III protein; This domain family is found in bacteria and viruses, and is typically between 126 and 146 amino acids in length. The family is found in association with pfam09327, pfam00041. There are two completely conserved G residues that may be functionally important. Many of the proteins in this family are annotated as fibronectin type III however there is little accompanying literature to confirm this.
The actual alignment was detected with superfamily member pfam12421:
Pssm-ID: 289206 Cd Length: 133 Bit Score: 136.25 E-value: 1.41e-37
Fibronectin type III protein; This domain family is found in bacteria and viruses, and is ...
475-615
1.41e-37
Fibronectin type III protein; This domain family is found in bacteria and viruses, and is typically between 126 and 146 amino acids in length. The family is found in association with pfam09327, pfam00041. There are two completely conserved G residues that may be functionally important. Many of the proteins in this family are annotated as fibronectin type III however there is little accompanying literature to confirm this.
Pssm-ID: 289206 Cd Length: 133 Bit Score: 136.25 E-value: 1.41e-37
Domain of unknown function (DUF1983); Members of this family of functionally uncharacterized ...
371-445
3.51e-21
Domain of unknown function (DUF1983); Members of this family of functionally uncharacterized domains are found in various bacteriophage host specificity proteins.
Pssm-ID: 430529 Cd Length: 75 Bit Score: 87.74 E-value: 3.51e-21
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
116-198
8.86e-04
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 38.75 E-value: 8.86e-04
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
116-208
3.25e-03
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 37.48 E-value: 3.25e-03
Fibronectin type III protein; This domain family is found in bacteria and viruses, and is ...
475-615
1.41e-37
Fibronectin type III protein; This domain family is found in bacteria and viruses, and is typically between 126 and 146 amino acids in length. The family is found in association with pfam09327, pfam00041. There are two completely conserved G residues that may be functionally important. Many of the proteins in this family are annotated as fibronectin type III however there is little accompanying literature to confirm this.
Pssm-ID: 289206 Cd Length: 133 Bit Score: 136.25 E-value: 1.41e-37
Domain of unknown function (DUF1983); Members of this family of functionally uncharacterized ...
371-445
3.51e-21
Domain of unknown function (DUF1983); Members of this family of functionally uncharacterized domains are found in various bacteriophage host specificity proteins.
Pssm-ID: 430529 Cd Length: 75 Bit Score: 87.74 E-value: 3.51e-21
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
116-198
8.86e-04
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 38.75 E-value: 8.86e-04
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
116-208
3.25e-03
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 37.48 E-value: 3.25e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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(labeled illustration) Four types of hits can be shown, as available,
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