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Conserved domains on  [gi|167377034|ref|XP_001734259|]
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40S ribosomal protein SA [Entamoeba dispar SAW760]

Protein Classification

uS2 family ribosomal protein( domain architecture ID 11488302)

uS2 family ribosomal protein is required for the assembly of different ribosomal subunits and is widely distributed among all living organisms.

Gene Ontology:  GO:0003735|GO:0000028|GO:0006412
PubMed:  24524803

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PTZ00254 PTZ00254
40S ribosomal protein SA; Provisional
6-228 6.54e-148

40S ribosomal protein SA; Provisional


:

Pssm-ID: 240331 [Multi-domain]  Cd Length: 249  Bit Score: 411.76  E-value: 6.54e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   6 KINFPDILKPSAEDIKMMVACRVHIGATNLNFAMEEYVYERGNNNECIFNLMKTWEKLSLAARVIAGISNetPSDVVAVA 85
Cdd:PTZ00254   1 VSSGPKVLTPKEDDIKKMLACKCHIGTKNLENAMKKYVYKRTKEGVHIINLAKTWEKLKLAARVIAAIEN--PADVVVVS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034  86 GREMAHRASLKFMKYTGCTAVAGRFTPGSFTNQIQKKFMEPRLIIVSDPSVDHQALRESGYINVPTIAFCNSDNSLKNVD 165
Cdd:PTZ00254  79 SRPYGQRAVLKFAQYTGASAIAGRFTPGTFTNQIQKKFMEPRLLIVTDPRTDHQAIREASYVNIPVIALCDTDSPLEYVD 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 167377034 166 IAIPCNNRSRLSIGLMWWMLTREILRYQGKLARDEKWDVMVDLFLHRELDAKKDAPVIAGEEK 228
Cdd:PTZ00254 159 IAIPCNNRGKESIALMYWLLAREVLRLRGTLPRDEEWDVMVDLFFWRDPEEAEEKEEAAAETA 221
 
Name Accession Description Interval E-value
PTZ00254 PTZ00254
40S ribosomal protein SA; Provisional
6-228 6.54e-148

40S ribosomal protein SA; Provisional


Pssm-ID: 240331 [Multi-domain]  Cd Length: 249  Bit Score: 411.76  E-value: 6.54e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   6 KINFPDILKPSAEDIKMMVACRVHIGATNLNFAMEEYVYERGNNNECIFNLMKTWEKLSLAARVIAGISNetPSDVVAVA 85
Cdd:PTZ00254   1 VSSGPKVLTPKEDDIKKMLACKCHIGTKNLENAMKKYVYKRTKEGVHIINLAKTWEKLKLAARVIAAIEN--PADVVVVS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034  86 GREMAHRASLKFMKYTGCTAVAGRFTPGSFTNQIQKKFMEPRLIIVSDPSVDHQALRESGYINVPTIAFCNSDNSLKNVD 165
Cdd:PTZ00254  79 SRPYGQRAVLKFAQYTGASAIAGRFTPGTFTNQIQKKFMEPRLLIVTDPRTDHQAIREASYVNIPVIALCDTDSPLEYVD 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 167377034 166 IAIPCNNRSRLSIGLMWWMLTREILRYQGKLARDEKWDVMVDLFLHRELDAKKDAPVIAGEEK 228
Cdd:PTZ00254 159 IAIPCNNRGKESIALMYWLLAREVLRLRGTLPRDEEWDVMVDLFFWRDPEEAEEKEEAAAETA 221
uS2_euk_arch TIGR01012
ribosomal protein uS2, eukaryotic/archaeal form; This model describes the ribosomal protein of ...
18-213 2.08e-92

ribosomal protein uS2, eukaryotic/archaeal form; This model describes the ribosomal protein of the cytosol and of Archaea, homologous to S2 of bacteria. It is designated typically as Sa in eukaryotes and Sa or S2 in the archaea. TIGR01011 describes the related protein of organelles and bacteria. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273394  Cd Length: 196  Bit Score: 269.30  E-value: 2.08e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   18 EDIKMMVACRVHIGATNLNFAMEEYVYERGNNNECIFNLMKTWEKLSLAARVIAGISnetPSDVVAVAGREMAHRASLKF 97
Cdd:TIGR01012   4 VPVDMYLAAGVHIGTQNKTFDMEKFIYKVRQDGLYVLDLRKTDERLRVAAKFLVAIE---PQDILVVSARIYGQKPVLKF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   98 MKYTGCTAVAGRFTPGSFTNQIQKKFMEPRLIIVSDPSVDHQALRESGYINVPTIAFCNSDNSLKNVDIAIPCNNRSRLS 177
Cdd:TIGR01012  81 AKVTGARAIAGRFTPGTFTNPAQKSFREPRVLIVTDPRADHQAVKEASEVGIPIVALCDTDNPLRYVDLVIPTNNKGRRS 160
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 167377034  178 IGLMWWMLTREILRYQGKLARDEKWDVMVDLFLHRE 213
Cdd:TIGR01012 161 LALIYWLLAREILRMRGTISPDEDWDVMVEEFFYRD 196
RPS2 cd01425
Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, ...
23-191 3.11e-61

Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ribosomal protein S1 to the 30s ribosomal subunit. In humans, most likely in all vertebrates, and perhaps in all metazoans, the protein also functions as the 67 kDa laminin receptor (LAMR1 or 67LR), which is formed from a 37 kDa precursor, and is overexpressed in many tumors. 67LR is a cell surface receptor which interacts with a variety of ligands, laminin-1 and others. It is assumed that the ligand interactions are mediated via the conserved C-terminus, which becomes extracellular as the protein undergoes conformational changes which are not well understood. Specifically, a conserved palindromic motif, LMWWML, may participate in the interactions. 67LR plays essential roles in the adhesion of cells to the basement membrane and subsequent signalling events, and has been linked to several diseases. Some evidence also suggests that the precursor of 67LR, 37LRP is also present in the nucleus in animals, where it appears associated with histones.


Pssm-ID: 100106  Cd Length: 193  Bit Score: 190.10  E-value: 3.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034  23 MVACRVHIGATNL--NFAMEEYVYERGNNNeCIFNLMKTWEKLSLAARVIAGISNEtPSDVVAVAGREMAHRASLKFMKY 100
Cdd:cd01425    1 LLEAGVHLGHKTRrwNPKMKPYIYGERNGI-HIIDLEKTLEKLRLALNFIANIAAK-GGKILFVGTKPQAQRAVKKFAER 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034 101 TGCTAVAGRFTPGSFTNQIQKK------------------------FMEPRLIIVSDPSVDHQALRESGYINVPTIAFCN 156
Cdd:cd01425   79 TGSFYVNGRWLGGTLTNWKTIRksikrlkklekekleknlggikdmFRLPDLVIVLDPRKEHQAIREASKLGIPVIAIVD 158
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 167377034 157 SDNSLKNVDIAIPCNNRSRLSIGLMWWMLTREILR 191
Cdd:cd01425  159 TNCDPDLIDYPIPANDDSIRSIALILWLLARAILE 193
Ribosomal_S2 pfam00318
Ribosomal protein S2;
23-181 1.90e-09

Ribosomal protein S2;


Pssm-ID: 459759  Cd Length: 216  Bit Score: 55.52  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   23 MVACRVHIG-ATNL-NFAMEEYVY-ERgnNNECIFNLMKTWEKLSLAARVIAGISnETPSDVVAVAGREMAHRASLKFMK 99
Cdd:pfam00318   1 LLEAGVHFGhQTRRwNPKMKPYIFgER--NGIHIIDLEKTLPLLRRAYKVVREVA-AKGGKILFVGTKKQAQEAIKEAAK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034  100 YTGCTAVAGRFTPGSFTN--QIQK------------------------------------------KFME--PRLIIVSD 133
Cdd:pfam00318  78 RCGMYYVNERWLGGMLTNfkTIRKsikrlkeleemeedgtfedltkkealtlkrerekleknlggiKDMKrlPDLLFVLD 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 167377034  134 PSVDHQALRESGYINVPTIAFCNSDNSLKNVDIAIPCNNRSRLSIGLM 181
Cdd:pfam00318 158 PNKEKIAVKEARKLGIPVIGIVDTNCDPDLVDYPIPGNDDAIRSIKLI 205
RpsB COG0052
Ribosomal protein S2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S2 ...
126-181 1.06e-03

Ribosomal protein S2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S2 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439822  Cd Length: 253  Bit Score: 39.32  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 167377034 126 PRLIIVSDPSVDHQALRESGYINVPTIAFCNSDNSLKNVDIAIPCNNRSRLSIGLM 181
Cdd:COG0052  158 PDALFVVDPKKEHIAVKEARKLGIPVVAIVDTNCDPDGVDYPIPGNDDAIRSIKLI 213
 
Name Accession Description Interval E-value
PTZ00254 PTZ00254
40S ribosomal protein SA; Provisional
6-228 6.54e-148

40S ribosomal protein SA; Provisional


Pssm-ID: 240331 [Multi-domain]  Cd Length: 249  Bit Score: 411.76  E-value: 6.54e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   6 KINFPDILKPSAEDIKMMVACRVHIGATNLNFAMEEYVYERGNNNECIFNLMKTWEKLSLAARVIAGISNetPSDVVAVA 85
Cdd:PTZ00254   1 VSSGPKVLTPKEDDIKKMLACKCHIGTKNLENAMKKYVYKRTKEGVHIINLAKTWEKLKLAARVIAAIEN--PADVVVVS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034  86 GREMAHRASLKFMKYTGCTAVAGRFTPGSFTNQIQKKFMEPRLIIVSDPSVDHQALRESGYINVPTIAFCNSDNSLKNVD 165
Cdd:PTZ00254  79 SRPYGQRAVLKFAQYTGASAIAGRFTPGTFTNQIQKKFMEPRLLIVTDPRTDHQAIREASYVNIPVIALCDTDSPLEYVD 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 167377034 166 IAIPCNNRSRLSIGLMWWMLTREILRYQGKLARDEKWDVMVDLFLHRELDAKKDAPVIAGEEK 228
Cdd:PTZ00254 159 IAIPCNNRGKESIALMYWLLAREVLRLRGTLPRDEEWDVMVDLFFWRDPEEAEEKEEAAAETA 221
uS2_euk_arch TIGR01012
ribosomal protein uS2, eukaryotic/archaeal form; This model describes the ribosomal protein of ...
18-213 2.08e-92

ribosomal protein uS2, eukaryotic/archaeal form; This model describes the ribosomal protein of the cytosol and of Archaea, homologous to S2 of bacteria. It is designated typically as Sa in eukaryotes and Sa or S2 in the archaea. TIGR01011 describes the related protein of organelles and bacteria. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273394  Cd Length: 196  Bit Score: 269.30  E-value: 2.08e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   18 EDIKMMVACRVHIGATNLNFAMEEYVYERGNNNECIFNLMKTWEKLSLAARVIAGISnetPSDVVAVAGREMAHRASLKF 97
Cdd:TIGR01012   4 VPVDMYLAAGVHIGTQNKTFDMEKFIYKVRQDGLYVLDLRKTDERLRVAAKFLVAIE---PQDILVVSARIYGQKPVLKF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   98 MKYTGCTAVAGRFTPGSFTNQIQKKFMEPRLIIVSDPSVDHQALRESGYINVPTIAFCNSDNSLKNVDIAIPCNNRSRLS 177
Cdd:TIGR01012  81 AKVTGARAIAGRFTPGTFTNPAQKSFREPRVLIVTDPRADHQAVKEASEVGIPIVALCDTDNPLRYVDLVIPTNNKGRRS 160
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 167377034  178 IGLMWWMLTREILRYQGKLARDEKWDVMVDLFLHRE 213
Cdd:TIGR01012 161 LALIYWLLAREILRMRGTISPDEDWDVMVEEFFYRD 196
RPS2 cd01425
Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, ...
23-191 3.11e-61

Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ribosomal protein S1 to the 30s ribosomal subunit. In humans, most likely in all vertebrates, and perhaps in all metazoans, the protein also functions as the 67 kDa laminin receptor (LAMR1 or 67LR), which is formed from a 37 kDa precursor, and is overexpressed in many tumors. 67LR is a cell surface receptor which interacts with a variety of ligands, laminin-1 and others. It is assumed that the ligand interactions are mediated via the conserved C-terminus, which becomes extracellular as the protein undergoes conformational changes which are not well understood. Specifically, a conserved palindromic motif, LMWWML, may participate in the interactions. 67LR plays essential roles in the adhesion of cells to the basement membrane and subsequent signalling events, and has been linked to several diseases. Some evidence also suggests that the precursor of 67LR, 37LRP is also present in the nucleus in animals, where it appears associated with histones.


Pssm-ID: 100106  Cd Length: 193  Bit Score: 190.10  E-value: 3.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034  23 MVACRVHIGATNL--NFAMEEYVYERGNNNeCIFNLMKTWEKLSLAARVIAGISNEtPSDVVAVAGREMAHRASLKFMKY 100
Cdd:cd01425    1 LLEAGVHLGHKTRrwNPKMKPYIYGERNGI-HIIDLEKTLEKLRLALNFIANIAAK-GGKILFVGTKPQAQRAVKKFAER 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034 101 TGCTAVAGRFTPGSFTNQIQKK------------------------FMEPRLIIVSDPSVDHQALRESGYINVPTIAFCN 156
Cdd:cd01425   79 TGSFYVNGRWLGGTLTNWKTIRksikrlkklekekleknlggikdmFRLPDLVIVLDPRKEHQAIREASKLGIPVIAIVD 158
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 167377034 157 SDNSLKNVDIAIPCNNRSRLSIGLMWWMLTREILR 191
Cdd:cd01425  159 TNCDPDLIDYPIPANDDSIRSIALILWLLARAILE 193
Ribosomal_S2 pfam00318
Ribosomal protein S2;
23-181 1.90e-09

Ribosomal protein S2;


Pssm-ID: 459759  Cd Length: 216  Bit Score: 55.52  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034   23 MVACRVHIG-ATNL-NFAMEEYVY-ERgnNNECIFNLMKTWEKLSLAARVIAGISnETPSDVVAVAGREMAHRASLKFMK 99
Cdd:pfam00318   1 LLEAGVHFGhQTRRwNPKMKPYIFgER--NGIHIIDLEKTLPLLRRAYKVVREVA-AKGGKILFVGTKKQAQEAIKEAAK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167377034  100 YTGCTAVAGRFTPGSFTN--QIQK------------------------------------------KFME--PRLIIVSD 133
Cdd:pfam00318  78 RCGMYYVNERWLGGMLTNfkTIRKsikrlkeleemeedgtfedltkkealtlkrerekleknlggiKDMKrlPDLLFVLD 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 167377034  134 PSVDHQALRESGYINVPTIAFCNSDNSLKNVDIAIPCNNRSRLSIGLM 181
Cdd:pfam00318 158 PNKEKIAVKEARKLGIPVIGIVDTNCDPDLVDYPIPGNDDAIRSIKLI 205
RpsB COG0052
Ribosomal protein S2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S2 ...
126-181 1.06e-03

Ribosomal protein S2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S2 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439822  Cd Length: 253  Bit Score: 39.32  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 167377034 126 PRLIIVSDPSVDHQALRESGYINVPTIAFCNSDNSLKNVDIAIPCNNRSRLSIGLM 181
Cdd:COG0052  158 PDALFVVDPKKEHIAVKEARKLGIPVVAIVDTNCDPDGVDYPIPGNDDAIRSIKLI 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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