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Conserved domains on  [gi|312079984|ref|XP_003142407|]
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hypothetical protein LOAG_06823 [Loa loa]

Protein Classification

MGR2/ROMO1 family protein( domain architecture ID 10563009)

MGR2/ROMO1 family protein such as fungal protein MGR2 (mitochondrial genome-required protein 2) and vertebrate Reactive oxygen species modulator 1 (ROMO1)

Gene Ontology:  GO:0030150|GO:0005743|GO:0005744|GO:0045039
TCDB:  1.A.111

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Romo1 pfam10247
Reactive mitochondrial oxygen species modulator 1; This is a family of small, approximately ...
 16-81 2.79e-16

Reactive mitochondrial oxygen species modulator 1; This is a family of small, approximately 100 amino acid, proteins found from yeasts to humans. The majority of endogenous reactive oxygen species (ROS) in cells are produced by the mitochondrial respiratory chain. An increase or imbalance in ROS alters the intracellular redox homeostasis, triggers DNA damage, and may contribute to cancer development and progression. Members of this family are mitochondrial reactive oxygen species modulator 1 (Romo1) proteins that are responsible for increasing the level of ROS in cells. Increased Romo1 expression can have a number of other effects including: inducing premature senescence of cultured human fibroblasts.and increased resistance to 5-fluorouracil.


:

Pssm-ID: 431168  Cd Length: 66  Bit Score: 66.05  E-value: 2.79e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312079984  16 SCWQKMKMGLLMGVFIGCASGAIIGTASAFSMGFRGRAMMAQVGRYSTKMGGSFAIFMMIAQGLRC 81
Cdd:pfam10247  1 SCFDKIKMGFMMGGAVGGAFGALFGGFTALRYGPRGRGLLRTLGKYMLGSAGTFGFFMSIGSVIRC 66
 
Name Accession Description Interval E-value
Romo1 pfam10247
Reactive mitochondrial oxygen species modulator 1; This is a family of small, approximately ...
 16-81 2.79e-16

Reactive mitochondrial oxygen species modulator 1; This is a family of small, approximately 100 amino acid, proteins found from yeasts to humans. The majority of endogenous reactive oxygen species (ROS) in cells are produced by the mitochondrial respiratory chain. An increase or imbalance in ROS alters the intracellular redox homeostasis, triggers DNA damage, and may contribute to cancer development and progression. Members of this family are mitochondrial reactive oxygen species modulator 1 (Romo1) proteins that are responsible for increasing the level of ROS in cells. Increased Romo1 expression can have a number of other effects including: inducing premature senescence of cultured human fibroblasts.and increased resistance to 5-fluorouracil.


Pssm-ID: 431168  Cd Length: 66  Bit Score: 66.05  E-value: 2.79e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312079984  16 SCWQKMKMGLLMGVFIGCASGAIIGTASAFSMGFRGRAMMAQVGRYSTKMGGSFAIFMMIAQGLRC 81
Cdd:pfam10247  1 SCFDKIKMGFMMGGAVGGAFGALFGGFTALRYGPRGRGLLRTLGKYMLGSAGTFGFFMSIGSVIRC 66
 
Name Accession Description Interval E-value
Romo1 pfam10247
Reactive mitochondrial oxygen species modulator 1; This is a family of small, approximately ...
 16-81 2.79e-16

Reactive mitochondrial oxygen species modulator 1; This is a family of small, approximately 100 amino acid, proteins found from yeasts to humans. The majority of endogenous reactive oxygen species (ROS) in cells are produced by the mitochondrial respiratory chain. An increase or imbalance in ROS alters the intracellular redox homeostasis, triggers DNA damage, and may contribute to cancer development and progression. Members of this family are mitochondrial reactive oxygen species modulator 1 (Romo1) proteins that are responsible for increasing the level of ROS in cells. Increased Romo1 expression can have a number of other effects including: inducing premature senescence of cultured human fibroblasts.and increased resistance to 5-fluorouracil.


Pssm-ID: 431168  Cd Length: 66  Bit Score: 66.05  E-value: 2.79e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312079984  16 SCWQKMKMGLLMGVFIGCASGAIIGTASAFSMGFRGRAMMAQVGRYSTKMGGSFAIFMMIAQGLRC 81
Cdd:pfam10247  1 SCFDKIKMGFMMGGAVGGAFGALFGGFTALRYGPRGRGLLRTLGKYMLGSAGTFGFFMSIGSVIRC 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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