cell migration-inducing and hyaluronan-binding protein isoform X1 [Gorilla gorilla gorilla]
Protein Classification
FAM3C domain-containing protein; glycosyltransferase family 13 protein( domain architecture ID 10562735)
FAM3C (FAM3 Metabolism Regulating Signaling Molecule C) domain-containing protein| glycosyltransferase family 13 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| PANDER_like_KIAA1199 | cd13941 | PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ... |
1245-1401 | 5.43e-104 | ||||
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized. : Pssm-ID: 260115 Cd Length: 157 Bit Score: 326.76 E-value: 5.43e-104
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| PANDER_like_TMEM2 | cd13938 | PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ... |
181-343 | 5.99e-95 | ||||
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized. : Pssm-ID: 260112 Cd Length: 168 Bit Score: 302.32 E-value: 5.99e-95
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| G8 | pfam10162 | G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ... |
86-205 | 1.26e-37 | ||||
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix. : Pssm-ID: 462971 Cd Length: 121 Bit Score: 137.35 E-value: 1.26e-37
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| Mucin2_WxxW | pfam13330 | Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ... |
365-443 | 1.63e-12 | ||||
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues. : Pssm-ID: 463846 [Multi-domain] Cd Length: 85 Bit Score: 64.28 E-value: 1.63e-12
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| Name | Accession | Description | Interval | E-value | ||||
| PANDER_like_KIAA1199 | cd13941 | PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ... |
1245-1401 | 5.43e-104 | ||||
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized. Pssm-ID: 260115 Cd Length: 157 Bit Score: 326.76 E-value: 5.43e-104
|
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| PANDER_like_TMEM2 | cd13938 | PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ... |
181-343 | 5.99e-95 | ||||
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized. Pssm-ID: 260112 Cd Length: 168 Bit Score: 302.32 E-value: 5.99e-95
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| G8 | pfam10162 | G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ... |
86-205 | 1.26e-37 | ||||
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix. Pssm-ID: 462971 Cd Length: 121 Bit Score: 137.35 E-value: 1.26e-37
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| ILEI | pfam15711 | Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ... |
227-316 | 1.61e-31 | ||||
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras. Pssm-ID: 464817 Cd Length: 89 Bit Score: 118.52 E-value: 1.61e-31
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| ILEI | pfam15711 | Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ... |
1284-1369 | 7.30e-18 | ||||
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras. Pssm-ID: 464817 Cd Length: 89 Bit Score: 79.61 E-value: 7.30e-18
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| Mucin2_WxxW | pfam13330 | Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ... |
365-443 | 1.63e-12 | ||||
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues. Pssm-ID: 463846 [Multi-domain] Cd Length: 85 Bit Score: 64.28 E-value: 1.63e-12
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| Name | Accession | Description | Interval | E-value | ||||
| PANDER_like_KIAA1199 | cd13941 | PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ... |
1245-1401 | 5.43e-104 | ||||
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized. Pssm-ID: 260115 Cd Length: 157 Bit Score: 326.76 E-value: 5.43e-104
|
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| PANDER_like_TMEM2 | cd13938 | PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ... |
181-343 | 5.99e-95 | ||||
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized. Pssm-ID: 260112 Cd Length: 168 Bit Score: 302.32 E-value: 5.99e-95
|
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| G8 | pfam10162 | G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ... |
86-205 | 1.26e-37 | ||||
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix. Pssm-ID: 462971 Cd Length: 121 Bit Score: 137.35 E-value: 1.26e-37
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| PANDER_like | cd13936 | Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ... |
1251-1401 | 3.63e-32 | ||||
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer. Pssm-ID: 260110 Cd Length: 149 Bit Score: 122.83 E-value: 3.63e-32
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| ILEI | pfam15711 | Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ... |
227-316 | 1.61e-31 | ||||
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras. Pssm-ID: 464817 Cd Length: 89 Bit Score: 118.52 E-value: 1.61e-31
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| PANDER_like | cd13936 | Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ... |
215-332 | 5.84e-27 | ||||
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer. Pssm-ID: 260110 Cd Length: 149 Bit Score: 107.81 E-value: 5.84e-27
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| PANDER_GnT-1_2_like | cd13937 | PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ... |
227-321 | 9.60e-20 | ||||
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined. Pssm-ID: 260111 Cd Length: 148 Bit Score: 87.35 E-value: 9.60e-20
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| ILEI | pfam15711 | Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ... |
1284-1369 | 7.30e-18 | ||||
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras. Pssm-ID: 464817 Cd Length: 89 Bit Score: 79.61 E-value: 7.30e-18
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| PANDER_FAM3B | cd13939 | Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ... |
227-327 | 1.71e-14 | ||||
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver. Pssm-ID: 260113 Cd Length: 175 Bit Score: 73.03 E-value: 1.71e-14
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| ILEI_FAM3C | cd13940 | Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ... |
227-326 | 2.94e-13 | ||||
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development. Pssm-ID: 260114 Cd Length: 171 Bit Score: 69.22 E-value: 2.94e-13
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| Mucin2_WxxW | pfam13330 | Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ... |
365-443 | 1.63e-12 | ||||
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues. Pssm-ID: 463846 [Multi-domain] Cd Length: 85 Bit Score: 64.28 E-value: 1.63e-12
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| Blast search parameters | ||||
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