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Conserved domains on  [gi|568948518|ref|XP_006541260|]
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protein ENTREP2 isoform X1 [Mus musculus]

Protein Classification

CD20-like domain-containing protein( domain architecture ID 10513721)

CD20-like domain-containing protein similar to Homo sapiens B-lymphocyte antigen CD20 that may be involved in the regulation of B-cell activation and proliferation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-154 3.97e-15

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


:

Pssm-ID: 461174  Cd Length: 155  Bit Score: 72.68  E-value: 3.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518   34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568948518  114 SCQNAQL-----------------------------------VSSLEGCQLDLLFSVCALNVLSTIVCALATAMCC 154
Cdd:pfam04103  80 LSLSLALltsaheccmsesdltpststcscksssedpecrayCSSLRGLFTGILSMLLILTVLELLVSLLSAILGC 155
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 225-402 2.05e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.30  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  225 FASSPFSTLYDVAINSPGILYPaelpppyEAVVGQTPASQVASvdHQVVDSSSGDPNTAADFSTPVPASSTS-------- 296
Cdd:pfam05109 421 FSKAPESTTTSPTLNTTGFAAP-------NTTTGLPSSTHVPT--NLTAPASTGPTVSTADVTSPTPAGTTSgaspvtps 491

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  297 -LPTSEGATSLGPSHPSPDGTLDTPTPLIPTPVPHHMSPEAASLSAQAQPSPGRVARSVSDPTSCTSSEAVSTSQPAMAA 375
Cdd:pfam05109 492 pSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI 571

                         170       180
                  ....*....|....*....|....*..
gi 568948518  376 CQHQHSSTGDPDTWKTGQGTKPETLQT 402
Cdd:pfam05109 572 PTLGKTSPTSAVTTPTPNATSPTVGET 598
 
Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-154 3.97e-15

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 72.68  E-value: 3.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518   34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568948518  114 SCQNAQL-----------------------------------VSSLEGCQLDLLFSVCALNVLSTIVCALATAMCC 154
Cdd:pfam04103  80 LSLSLALltsaheccmsesdltpststcscksssedpecrayCSSLRGLFTGILSMLLILTVLELLVSLLSAILGC 155
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 225-402 2.05e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.30  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  225 FASSPFSTLYDVAINSPGILYPaelpppyEAVVGQTPASQVASvdHQVVDSSSGDPNTAADFSTPVPASSTS-------- 296
Cdd:pfam05109 421 FSKAPESTTTSPTLNTTGFAAP-------NTTTGLPSSTHVPT--NLTAPASTGPTVSTADVTSPTPAGTTSgaspvtps 491

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  297 -LPTSEGATSLGPSHPSPDGTLDTPTPLIPTPVPHHMSPEAASLSAQAQPSPGRVARSVSDPTSCTSSEAVSTSQPAMAA 375
Cdd:pfam05109 492 pSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI 571

                         170       180
                  ....*....|....*....|....*..
gi 568948518  376 CQHQHSSTGDPDTWKTGQGTKPETLQT 402
Cdd:pfam05109 572 PTLGKTSPTSAVTTPTPNATSPTVGET 598
PHA03247 PHA03247
large tegument protein UL36; Provisional
 246-386 3.24e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  246 PAELPPPYEAVVGQTPASQVASVDHQVVDSSSGDPNTAADFSTPVPASSTSLPTSEGATSLGPSHPSPDGTLDTPTPLIP 325
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568948518  326 TPVPHHMSPEAASLSAQAQPSPGRVARSVSDPTSCTSSEAVSTSQPAMAACQHQHSSTGDP 386
Cdd:PHA03247 2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
fibronec_FbpA NF033913
LPXTG-anchored fibronectin-binding protein FbpA; FbpA, a fibronectin-binding protein described ...
 236-410 9.29e-04

LPXTG-anchored fibronectin-binding protein FbpA; FbpA, a fibronectin-binding protein described in Streptococcus pyogenes, has a YSIRK-type (crosswall-targeting) signal peptide and a C-terminal LPXTG motif for covalent attachment to the cell wall. It is unrelated to the PavA-like protein from Streptococcus gordonii (see BlastRule NBR009716) that was given the identical name, so the phase LPXTG-anchored is added to the protein name for clarity.


Pssm-ID: 468243 [Multi-domain]  Cd Length: 386  Bit Score: 41.59  E-value: 9.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518 236 VAINSPGILYPAELPPPYEAVVGQTPASQVASVDHQVVDSS--SGDPNTAADFSTP-VPASSTSLPTSEGATSLGPSH-P 311
Cdd:NF033913 159 VTTDSPEETPSSETPAPSIPALPEAPAQSAESEEPSVAASSeeTPSPETPAAPETPeEPAAPAPSPESEPSVAASSEEtP 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518 312 SPDGTLDTPTPLIPTPVPHHMSPEAASLSAQAQPSPGRVARSVSD--PTSCTSSEAVSTSQPAMAACQHQHSSTGDPDTW 389
Cdd:NF033913 239 SPSTPAAPETPAESEAPAQPAESEESSVAATTSPSPSTPAESETQtpPAVTKDSDKPSSAAEKPAASSLVSEQTVQQPTS 318

                        170       180
                 ....*....|....*....|.
gi 568948518 390 KTGQGTKPETLQTVSKERPHS 410
Cdd:NF033913 319 KRSSDKKEEQEQSYSPNRSLS 339
 
Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-154 3.97e-15

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 72.68  E-value: 3.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518   34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568948518  114 SCQNAQL-----------------------------------VSSLEGCQLDLLFSVCALNVLSTIVCALATAMCC 154
Cdd:pfam04103  80 LSLSLALltsaheccmsesdltpststcscksssedpecrayCSSLRGLFTGILSMLLILTVLELLVSLLSAILGC 155
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 225-402 2.05e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.30  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  225 FASSPFSTLYDVAINSPGILYPaelpppyEAVVGQTPASQVASvdHQVVDSSSGDPNTAADFSTPVPASSTS-------- 296
Cdd:pfam05109 421 FSKAPESTTTSPTLNTTGFAAP-------NTTTGLPSSTHVPT--NLTAPASTGPTVSTADVTSPTPAGTTSgaspvtps 491

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  297 -LPTSEGATSLGPSHPSPDGTLDTPTPLIPTPVPHHMSPEAASLSAQAQPSPGRVARSVSDPTSCTSSEAVSTSQPAMAA 375
Cdd:pfam05109 492 pSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATI 571

                         170       180
                  ....*....|....*....|....*..
gi 568948518  376 CQHQHSSTGDPDTWKTGQGTKPETLQT 402
Cdd:pfam05109 572 PTLGKTSPTSAVTTPTPNATSPTVGET 598
PHA03247 PHA03247
large tegument protein UL36; Provisional
 246-386 3.24e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  246 PAELPPPYEAVVGQTPASQVASVDHQVVDSSSGDPNTAADFSTPVPASSTSLPTSEGATSLGPSHPSPDGTLDTPTPLIP 325
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568948518  326 TPVPHHMSPEAASLSAQAQPSPGRVARSVSDPTSCTSSEAVSTSQPAMAACQHQHSSTGDP 386
Cdd:PHA03247 2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
motB PRK12799
flagellar motor protein MotB; Reviewed
 258-383 5.70e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 42.01  E-value: 5.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518 258 GQTPAsqVASVDHQVVDSSSGDPN----TAADFSTPVPASSTSL-PTSEGATSLGPSHPSPDGTLDTPTPLIPTPVPHHM 332
Cdd:PRK12799 297 GTVPV--AAVTPSSAVTQSSAITPssaaIPSPAVIPSSVTTQSAtTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVNM 374

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568948518 333 SPEAASLSAQAQPSPGRVARSVSDPTsctsseavsTSQPAMAACQHQHSST 383
Cdd:PRK12799 375 QPQPMSTTETQQSSTGNITSTANGPT---------TSLPAAPASNIPVSPT 416
fibronec_FbpA NF033913
LPXTG-anchored fibronectin-binding protein FbpA; FbpA, a fibronectin-binding protein described ...
 236-410 9.29e-04

LPXTG-anchored fibronectin-binding protein FbpA; FbpA, a fibronectin-binding protein described in Streptococcus pyogenes, has a YSIRK-type (crosswall-targeting) signal peptide and a C-terminal LPXTG motif for covalent attachment to the cell wall. It is unrelated to the PavA-like protein from Streptococcus gordonii (see BlastRule NBR009716) that was given the identical name, so the phase LPXTG-anchored is added to the protein name for clarity.


Pssm-ID: 468243 [Multi-domain]  Cd Length: 386  Bit Score: 41.59  E-value: 9.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518 236 VAINSPGILYPAELPPPYEAVVGQTPASQVASVDHQVVDSS--SGDPNTAADFSTP-VPASSTSLPTSEGATSLGPSH-P 311
Cdd:NF033913 159 VTTDSPEETPSSETPAPSIPALPEAPAQSAESEEPSVAASSeeTPSPETPAAPETPeEPAAPAPSPESEPSVAASSEEtP 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518 312 SPDGTLDTPTPLIPTPVPHHMSPEAASLSAQAQPSPGRVARSVSD--PTSCTSSEAVSTSQPAMAACQHQHSSTGDPDTW 389
Cdd:NF033913 239 SPSTPAAPETPAESEAPAQPAESEESSVAATTSPSPSTPAESETQtpPAVTKDSDKPSSAAEKPAASSLVSEQTVQQPTS 318

                        170       180
                 ....*....|....*....|.
gi 568948518 390 KTGQGTKPETLQTVSKERPHS 410
Cdd:NF033913 319 KRSSDKKEEQEQSYSPNRSLS 339
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 288-386 3.79e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.79  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518 288 TPVPASSTSLPTSegatslgpshPSPDGTLDTPTPLIPTPVPHHMSPEAASLSAQAQPSPGRVARSVSDPTScTSSEAVS 367
Cdd:PRK14950 361 VPVPAPQPAKPTA----------AAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVP-HTPESAP 429

                         90
                 ....*....|....*....
gi 568948518 368 TSQPAMAACQHQHSSTGDP 386
Cdd:PRK14950 430 KLTRAAIPVDEKPKYTPPA 448
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 250-388 4.73e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.56  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568948518  250 PPPYEAVVGQTPASQVaSVDHQVVdSSSGDPntaadfsTPVPASSTSLPTSEGATSLGPSHPSPDGTLDTPTPLI-PTPV 328
Cdd:pfam17823 295 PAAPMGAQAQGPIIQV-STDQPVH-NTAGEP-------TPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSAsPVPV 365

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568948518  329 PH-HMSPEAASLSAQAQPSPGRVARSVSDPTSCTSSEAVST-SQPAMAACQHQHSSTGDPDT 388
Cdd:pfam17823 366 LHtSMIPEVEATSPTTQPSPLLPTQGAAGPGILLAPEQVATeATAGTASAGPTPRSSGDPKT 427
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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