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Conserved domains on  [gi|578807525|ref|XP_006713744|]
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solute carrier family 41 member 3 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
319-456 3.60e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 83.26  E-value: 3.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525  319 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 398
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578807525  399 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLG 456
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLG 117
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
106-240 3.52e-16

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 74.78  E-value: 3.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525  106 VPPLVGLKGNLEMTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLC 185
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVV 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578807525  186 ASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 240
Cdd:pfam01769  73 GLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
319-456 3.60e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 83.26  E-value: 3.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525  319 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 398
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578807525  399 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLG 456
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLG 117
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
106-240 3.52e-16

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 74.78  E-value: 3.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525  106 VPPLVGLKGNLEMTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLC 185
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVV 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578807525  186 ASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 240
Cdd:pfam01769  73 GLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
57-244 2.65e-11

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 62.57  E-value: 2.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525  57 PSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQhwPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQID-D 135
Cdd:COG1824    2 TVRWTVRRIVRESLPVLLVLAVGGIIAGLVLEGME--ELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHLGLLEpR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525 136 PQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCassVLTAFLAAFALGVLMVCIVIGARKLGV 215
Cdd:COG1824   80 LRPDRRLLNNILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTLVGIA---LLAGLLLALLLIVVTYYVAIASYRFGL 156
                        170       180
                 ....*....|....*....|....*....
gi 578807525 216 NPDNIATPIAASLGDLITLSILALVSSFF 244
Cdd:COG1824  157 DPDNVVIPVVTTLGDVFGVLFLILVARLV 185
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
278-456 9.06e-11

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 61.03  E-value: 9.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525 278 IVKILKFGWFPIILAMVISSFGGLIL-SKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMwsapGVLPlqmKK 356
Cdd:COG1824    7 VRRIVRESLPVLLVLAVGGIIAGLVLeGMEELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525 357 FWPNP--CSTFCTSEINSMSARVLLLLVVpghliffYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTW 434
Cdd:COG1824   80 LRPDRrlLNNILATLILALLISPLIGVLA-------WLVAVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASY 152
                        170       180
                 ....*....|....*....|..
gi 578807525 435 HQALDPDNHCIPYLTGLGDLLG 456
Cdd:COG1824  153 RFGLDPDNVVIPVVTTLGDVFG 174
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
319-456 3.60e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 83.26  E-value: 3.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525  319 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 398
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578807525  399 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLG 456
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLG 117
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
106-240 3.52e-16

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 74.78  E-value: 3.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525  106 VPPLVGLKGNLEMTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLC 185
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVV 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578807525  186 ASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 240
Cdd:pfam01769  73 GLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
57-244 2.65e-11

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 62.57  E-value: 2.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525  57 PSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQhwPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQID-D 135
Cdd:COG1824    2 TVRWTVRRIVRESLPVLLVLAVGGIIAGLVLEGME--ELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHLGLLEpR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525 136 PQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCassVLTAFLAAFALGVLMVCIVIGARKLGV 215
Cdd:COG1824   80 LRPDRRLLNNILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTLVGIA---LLAGLLLALLLIVVTYYVAIASYRFGL 156
                        170       180
                 ....*....|....*....|....*....
gi 578807525 216 NPDNIATPIAASLGDLITLSILALVSSFF 244
Cdd:COG1824  157 DPDNVVIPVVTTLGDVFGVLFLILVARLV 185
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
278-456 9.06e-11

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 61.03  E-value: 9.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525 278 IVKILKFGWFPIILAMVISSFGGLIL-SKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMwsapGVLPlqmKK 356
Cdd:COG1824    7 VRRIVRESLPVLLVLAVGGIIAGLVLeGMEELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807525 357 FWPNP--CSTFCTSEINSMSARVLLLLVVpghliffYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTW 434
Cdd:COG1824   80 LRPDRrlLNNILATLILALLISPLIGVLA-------WLVAVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASY 152
                        170       180
                 ....*....|....*....|..
gi 578807525 435 HQALDPDNHCIPYLTGLGDLLG 456
Cdd:COG1824  153 RFGLDPDNVVIPVVTTLGDVFG 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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