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Conserved domains on  [gi|585681565|ref|XP_006819889|]
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PREDICTED: nephrocystin-4-like [Saccoglossus kowalevskii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPHP4 cd22239
Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the ...
 57-1545 0e+00

Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the nephronophthisis (NPHP) module which is part of the transition zone (TZ) of the cilia. NPHP4 forms complexes with alpha-tubulin, NPHP1 and RPGRIP1. The interaction with NPHP1 is crucial for cell-cell and cell-matrix adhesion signaling. Mutations in NPHP4 have been shown to cause nephronophthisis (NPHP), an autosomal recessive cause of kidney failure and earlier stages of chronic kidney disease among adults.


:

Pssm-ID: 412072  Cd Length: 904  Bit Score: 1226.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565   57 EYEIRVSLFDIIYKKFFGRTWVGPAKSVKSSASQKARLQYNVPVYFHTSLNDPNIVIVVEIVGIITTKKNKVQRVSCGWG 136
Cdd:cd22239     1 EYQLRVSLFDSTYKHFFGRTWKSPSVTLKSSQGQKIKLLFNEPVYFHTSLNDPSIVAVVEVVAVEKDKDGIKNRTSCGWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  137 IIRIFKDGHlgDLSSPTPEPVKRMDVYHGSPRALLYLDDDIEKNEKITLIAECQLCYVIRTHKLLRKVMHLLPENIIAGS 216
Cdd:cd22239    81 LLRIFKVSQ--EPPDTLVSQVKRLDLYHGTPRALLHPDLPIETNENIKVVEGCQLLYTLRTHKALEKIFHLLPENVLVGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  217 NSIIPGLYS--------------------QDDKLQIYLYPTIEKFEEELCKLLNADRLARDDIPSDANVVHINERRLQVG 276
Cdd:cd22239   159 SDKIPGILPissdsglaltkpkllktficYLDKIQITLPPSIEKFEEELCKLLNEDRLNKDGGDTDGNSVIILERRLRVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  277 VHNGWGYVQPPQtymlvsdavskggrgsmrkskgrptsagsreslstaLILKNKVRL-ELIEDPLFAVVFNLEYMLSVPV 355
Cdd:cd22239   239 VHNGWCYVQKPQ------------------------------------LVLRSRVQLpEMVQDPDFAVVFQLEYVFSVPV 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  356 STTDRKLSTsmNRVQSRNVSLRWAAWTPFAHDGMAEITLQLQGdpipnpdsvlvfknpdvemtdqeaskiapgriqfmfr 435
Cdd:cd22239   283 AASGRKAST--LSSAAYMVLVRWAAWSPFSEGGSSEVTLPLRG------------------------------------- 323

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  436 tkkdmsssrpgsaasmrsesfrqgfdsyrstgqathmetsmdvgmphyqtglapheqssvegsmlgeshpsqyparppip 515
Cdd:cd22239       --------------------------------------------------------------------------------

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  516 kGSPRTPRSMQMGtpngmmmglppvppqqqyygqqqiyssiqpiphsgtgnvypveikhleastartvspdqltelpftp 595
Cdd:cd22239   324 -GPSPNPDNLLVY------------------------------------------------------------------- 335

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  596 vhapimpvgqlqqtgpSLTRASYARLYQAGFPPVLDRNGEPPEVVDPNDYVTFHPQHEDADPLQINEIVLQFLAFSRMVQ 675
Cdd:cd22239   336 ----------------KLSRAAYARLYTSGFPEILDRNGEPAEVVDPSDPVNFDLQREEADPLQTNEIILQFLAFSRIAQ 399

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  676 FENQgqPRQHNTIFFTFQFYRYPQITTERLFLGEVdgglsADPSslpcilqklskdgtilegppgvttrggsvrpvgvtt 755
Cdd:cd22239   400 DKSE--SRWPKSLFFTFQFYRFPPVTTEGLQLKYV-----VDPS------------------------------------ 436

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  756 ilkgrlhlrmanighpievkllkagnthlqksrvvvqdegsgtflggslntisspkyycnistkyaqrqysdhfnrylvp 835
Cdd:cd22239       --------------------------------------------------------------------------------

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  836 iclfcgillkaQFRPGEGKMFVRFLYQQTLHIDVWDGDSLLLIGSCALPLKHLLRSGRDAVQVTHELDVITteytedspa 915
Cdd:cd22239   437 -----------FLKPGEARLFLQYLAVQTLHIDVWDGDSLLLIGSAAVPLKHLLRQGRDAVQVSHELDVID--------- 496

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  916 ltgdltrggsvrpvgvttilkgrlhlrmanighpievkllkagnthlqksrvvvqdegsgtflggslntisspklslyag 995
Cdd:cd22239       --------------------------------------------------------------------------------

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  996 mkltrtyraahmadtdrelaallfsrkdkavlqdsnreadevkkRKLNRMEAIRKNESENGLIST---LLIKKEEKIQRA 1072
Cdd:cd22239   497 --------------------------------------------RKLARMQAVRQQESPNEDPSFgnrVLAEKEERTQRT 532

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1073 RDLKTIEVYRERSKKEGIRSMLQSAITTEHTIHPSFGHAEFFEFILKNPYNVQHTVYIQCDDPDLQVVTDTREWRHYKQL 1152
Cdd:cd22239   533 RDLQTIEAYRERTKREFILSMLSQAITTEHTIHPSFGTAEFFEFVLKNPYNVQHTVTIEIDDPELSVITDAREWRYFKEL 612

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1153 TETYTPVEENMFSGEAQNDLPgiQVFLRPKESINIPLKYQsfkadhsvhpqgpynphrplinmqmpeqnkvdlslqsrnt 1232
Cdd:cd22239   613 NNVTTPLEENMFHLNPDTLRP--QVFLRPKETVHIPFKYQ---------------------------------------- 650

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1233 kvyfktgddrpiailslniepqPQIVDQTFRFHHPEQSFLKKSVRLPPFQSLPGAPVGGAGLHGLFVRCSDPNVICESKR 1312
Cdd:cd22239   651 ----------------------PHVVDQTFRFYHPEQSFLKKSIRLPPFHTLPGAPVGPGGLRQVHVRCSDPNVICETRN 708

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1313 VAPGEPQDVFIKVACGASPAIKKFFIIIYGDQFLSRPVQTWQFYIHALQRVDVTCVEGQTSRFSLILRGTQSSRLtqcfs 1392
Cdd:cd22239   709 LTPGEPQDVFIKVASGPSPQIKKFFVLIYSDPYLARPIQIWQFYVHALQRVDVSCVEGQTSRFSLVLRGTQSSRV----- 783

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1393 shpiemqispvepfmllansvheihvgvrptsVGSKFMYINVVDTEYHQLVRSWLICVTCRQPVISKAFELQLPVGGGKG 1472
Cdd:cd22239   784 --------------------------------VGSKFLYVNVVDTETHQLVRSWLVCISCRQPVISKAFEIQLPVGGGKG 831

                        1450      1460      1470      1480      1490      1500      1510
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 585681565 1473 SNKRISYTNPYPYKKVFNLRSNRDDLLQFKETKIEIGAGQVHTIGLRFTPSQVPGSAEILIFINDAEDKNEET 1545
Cdd:cd22239   832 CNKRISYTNPYPNRKTFHLRTNRSDLLQFKETRLEVGAGETYTIGLRFAPSQTPGKEEILIFINDEEDKNEET 904
 
Name Accession Description Interval E-value
NPHP4 cd22239
Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the ...
 57-1545 0e+00

Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the nephronophthisis (NPHP) module which is part of the transition zone (TZ) of the cilia. NPHP4 forms complexes with alpha-tubulin, NPHP1 and RPGRIP1. The interaction with NPHP1 is crucial for cell-cell and cell-matrix adhesion signaling. Mutations in NPHP4 have been shown to cause nephronophthisis (NPHP), an autosomal recessive cause of kidney failure and earlier stages of chronic kidney disease among adults.


Pssm-ID: 412072  Cd Length: 904  Bit Score: 1226.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565   57 EYEIRVSLFDIIYKKFFGRTWVGPAKSVKSSASQKARLQYNVPVYFHTSLNDPNIVIVVEIVGIITTKKNKVQRVSCGWG 136
Cdd:cd22239     1 EYQLRVSLFDSTYKHFFGRTWKSPSVTLKSSQGQKIKLLFNEPVYFHTSLNDPSIVAVVEVVAVEKDKDGIKNRTSCGWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  137 IIRIFKDGHlgDLSSPTPEPVKRMDVYHGSPRALLYLDDDIEKNEKITLIAECQLCYVIRTHKLLRKVMHLLPENIIAGS 216
Cdd:cd22239    81 LLRIFKVSQ--EPPDTLVSQVKRLDLYHGTPRALLHPDLPIETNENIKVVEGCQLLYTLRTHKALEKIFHLLPENVLVGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  217 NSIIPGLYS--------------------QDDKLQIYLYPTIEKFEEELCKLLNADRLARDDIPSDANVVHINERRLQVG 276
Cdd:cd22239   159 SDKIPGILPissdsglaltkpkllktficYLDKIQITLPPSIEKFEEELCKLLNEDRLNKDGGDTDGNSVIILERRLRVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  277 VHNGWGYVQPPQtymlvsdavskggrgsmrkskgrptsagsreslstaLILKNKVRL-ELIEDPLFAVVFNLEYMLSVPV 355
Cdd:cd22239   239 VHNGWCYVQKPQ------------------------------------LVLRSRVQLpEMVQDPDFAVVFQLEYVFSVPV 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  356 STTDRKLSTsmNRVQSRNVSLRWAAWTPFAHDGMAEITLQLQGdpipnpdsvlvfknpdvemtdqeaskiapgriqfmfr 435
Cdd:cd22239   283 AASGRKAST--LSSAAYMVLVRWAAWSPFSEGGSSEVTLPLRG------------------------------------- 323

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  436 tkkdmsssrpgsaasmrsesfrqgfdsyrstgqathmetsmdvgmphyqtglapheqssvegsmlgeshpsqyparppip 515
Cdd:cd22239       --------------------------------------------------------------------------------

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  516 kGSPRTPRSMQMGtpngmmmglppvppqqqyygqqqiyssiqpiphsgtgnvypveikhleastartvspdqltelpftp 595
Cdd:cd22239   324 -GPSPNPDNLLVY------------------------------------------------------------------- 335

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  596 vhapimpvgqlqqtgpSLTRASYARLYQAGFPPVLDRNGEPPEVVDPNDYVTFHPQHEDADPLQINEIVLQFLAFSRMVQ 675
Cdd:cd22239   336 ----------------KLSRAAYARLYTSGFPEILDRNGEPAEVVDPSDPVNFDLQREEADPLQTNEIILQFLAFSRIAQ 399

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  676 FENQgqPRQHNTIFFTFQFYRYPQITTERLFLGEVdgglsADPSslpcilqklskdgtilegppgvttrggsvrpvgvtt 755
Cdd:cd22239   400 DKSE--SRWPKSLFFTFQFYRFPPVTTEGLQLKYV-----VDPS------------------------------------ 436

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  756 ilkgrlhlrmanighpievkllkagnthlqksrvvvqdegsgtflggslntisspkyycnistkyaqrqysdhfnrylvp 835
Cdd:cd22239       --------------------------------------------------------------------------------

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  836 iclfcgillkaQFRPGEGKMFVRFLYQQTLHIDVWDGDSLLLIGSCALPLKHLLRSGRDAVQVTHELDVITteytedspa 915
Cdd:cd22239   437 -----------FLKPGEARLFLQYLAVQTLHIDVWDGDSLLLIGSAAVPLKHLLRQGRDAVQVSHELDVID--------- 496

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  916 ltgdltrggsvrpvgvttilkgrlhlrmanighpievkllkagnthlqksrvvvqdegsgtflggslntisspklslyag 995
Cdd:cd22239       --------------------------------------------------------------------------------

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  996 mkltrtyraahmadtdrelaallfsrkdkavlqdsnreadevkkRKLNRMEAIRKNESENGLIST---LLIKKEEKIQRA 1072
Cdd:cd22239   497 --------------------------------------------RKLARMQAVRQQESPNEDPSFgnrVLAEKEERTQRT 532

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1073 RDLKTIEVYRERSKKEGIRSMLQSAITTEHTIHPSFGHAEFFEFILKNPYNVQHTVYIQCDDPDLQVVTDTREWRHYKQL 1152
Cdd:cd22239   533 RDLQTIEAYRERTKREFILSMLSQAITTEHTIHPSFGTAEFFEFVLKNPYNVQHTVTIEIDDPELSVITDAREWRYFKEL 612

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1153 TETYTPVEENMFSGEAQNDLPgiQVFLRPKESINIPLKYQsfkadhsvhpqgpynphrplinmqmpeqnkvdlslqsrnt 1232
Cdd:cd22239   613 NNVTTPLEENMFHLNPDTLRP--QVFLRPKETVHIPFKYQ---------------------------------------- 650

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1233 kvyfktgddrpiailslniepqPQIVDQTFRFHHPEQSFLKKSVRLPPFQSLPGAPVGGAGLHGLFVRCSDPNVICESKR 1312
Cdd:cd22239   651 ----------------------PHVVDQTFRFYHPEQSFLKKSIRLPPFHTLPGAPVGPGGLRQVHVRCSDPNVICETRN 708

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1313 VAPGEPQDVFIKVACGASPAIKKFFIIIYGDQFLSRPVQTWQFYIHALQRVDVTCVEGQTSRFSLILRGTQSSRLtqcfs 1392
Cdd:cd22239   709 LTPGEPQDVFIKVASGPSPQIKKFFVLIYSDPYLARPIQIWQFYVHALQRVDVSCVEGQTSRFSLVLRGTQSSRV----- 783

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1393 shpiemqispvepfmllansvheihvgvrptsVGSKFMYINVVDTEYHQLVRSWLICVTCRQPVISKAFELQLPVGGGKG 1472
Cdd:cd22239   784 --------------------------------VGSKFLYVNVVDTETHQLVRSWLVCISCRQPVISKAFEIQLPVGGGKG 831

                        1450      1460      1470      1480      1490      1500      1510
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 585681565 1473 SNKRISYTNPYPYKKVFNLRSNRDDLLQFKETKIEIGAGQVHTIGLRFTPSQVPGSAEILIFINDAEDKNEET 1545
Cdd:cd22239   832 CNKRISYTNPYPNRKTFHLRTNRSDLLQFKETRLEVGAGETYTIGLRFAPSQTPGKEEILIFINDEEDKNEET 904
 
Name Accession Description Interval E-value
NPHP4 cd22239
Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the ...
 57-1545 0e+00

Nephrocystin-4; Nephrocystin-4 (NPHP4), also known as nephroretinin, is a component of the nephronophthisis (NPHP) module which is part of the transition zone (TZ) of the cilia. NPHP4 forms complexes with alpha-tubulin, NPHP1 and RPGRIP1. The interaction with NPHP1 is crucial for cell-cell and cell-matrix adhesion signaling. Mutations in NPHP4 have been shown to cause nephronophthisis (NPHP), an autosomal recessive cause of kidney failure and earlier stages of chronic kidney disease among adults.


Pssm-ID: 412072  Cd Length: 904  Bit Score: 1226.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565   57 EYEIRVSLFDIIYKKFFGRTWVGPAKSVKSSASQKARLQYNVPVYFHTSLNDPNIVIVVEIVGIITTKKNKVQRVSCGWG 136
Cdd:cd22239     1 EYQLRVSLFDSTYKHFFGRTWKSPSVTLKSSQGQKIKLLFNEPVYFHTSLNDPSIVAVVEVVAVEKDKDGIKNRTSCGWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  137 IIRIFKDGHlgDLSSPTPEPVKRMDVYHGSPRALLYLDDDIEKNEKITLIAECQLCYVIRTHKLLRKVMHLLPENIIAGS 216
Cdd:cd22239    81 LLRIFKVSQ--EPPDTLVSQVKRLDLYHGTPRALLHPDLPIETNENIKVVEGCQLLYTLRTHKALEKIFHLLPENVLVGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  217 NSIIPGLYS--------------------QDDKLQIYLYPTIEKFEEELCKLLNADRLARDDIPSDANVVHINERRLQVG 276
Cdd:cd22239   159 SDKIPGILPissdsglaltkpkllktficYLDKIQITLPPSIEKFEEELCKLLNEDRLNKDGGDTDGNSVIILERRLRVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  277 VHNGWGYVQPPQtymlvsdavskggrgsmrkskgrptsagsreslstaLILKNKVRL-ELIEDPLFAVVFNLEYMLSVPV 355
Cdd:cd22239   239 VHNGWCYVQKPQ------------------------------------LVLRSRVQLpEMVQDPDFAVVFQLEYVFSVPV 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  356 STTDRKLSTsmNRVQSRNVSLRWAAWTPFAHDGMAEITLQLQGdpipnpdsvlvfknpdvemtdqeaskiapgriqfmfr 435
Cdd:cd22239   283 AASGRKAST--LSSAAYMVLVRWAAWSPFSEGGSSEVTLPLRG------------------------------------- 323

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  436 tkkdmsssrpgsaasmrsesfrqgfdsyrstgqathmetsmdvgmphyqtglapheqssvegsmlgeshpsqyparppip 515
Cdd:cd22239       --------------------------------------------------------------------------------

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  516 kGSPRTPRSMQMGtpngmmmglppvppqqqyygqqqiyssiqpiphsgtgnvypveikhleastartvspdqltelpftp 595
Cdd:cd22239   324 -GPSPNPDNLLVY------------------------------------------------------------------- 335

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  596 vhapimpvgqlqqtgpSLTRASYARLYQAGFPPVLDRNGEPPEVVDPNDYVTFHPQHEDADPLQINEIVLQFLAFSRMVQ 675
Cdd:cd22239   336 ----------------KLSRAAYARLYTSGFPEILDRNGEPAEVVDPSDPVNFDLQREEADPLQTNEIILQFLAFSRIAQ 399

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  676 FENQgqPRQHNTIFFTFQFYRYPQITTERLFLGEVdgglsADPSslpcilqklskdgtilegppgvttrggsvrpvgvtt 755
Cdd:cd22239   400 DKSE--SRWPKSLFFTFQFYRFPPVTTEGLQLKYV-----VDPS------------------------------------ 436

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  756 ilkgrlhlrmanighpievkllkagnthlqksrvvvqdegsgtflggslntisspkyycnistkyaqrqysdhfnrylvp 835
Cdd:cd22239       --------------------------------------------------------------------------------

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  836 iclfcgillkaQFRPGEGKMFVRFLYQQTLHIDVWDGDSLLLIGSCALPLKHLLRSGRDAVQVTHELDVITteytedspa 915
Cdd:cd22239   437 -----------FLKPGEARLFLQYLAVQTLHIDVWDGDSLLLIGSAAVPLKHLLRQGRDAVQVSHELDVID--------- 496

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  916 ltgdltrggsvrpvgvttilkgrlhlrmanighpievkllkagnthlqksrvvvqdegsgtflggslntisspklslyag 995
Cdd:cd22239       --------------------------------------------------------------------------------

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565  996 mkltrtyraahmadtdrelaallfsrkdkavlqdsnreadevkkRKLNRMEAIRKNESENGLIST---LLIKKEEKIQRA 1072
Cdd:cd22239   497 --------------------------------------------RKLARMQAVRQQESPNEDPSFgnrVLAEKEERTQRT 532

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1073 RDLKTIEVYRERSKKEGIRSMLQSAITTEHTIHPSFGHAEFFEFILKNPYNVQHTVYIQCDDPDLQVVTDTREWRHYKQL 1152
Cdd:cd22239   533 RDLQTIEAYRERTKREFILSMLSQAITTEHTIHPSFGTAEFFEFVLKNPYNVQHTVTIEIDDPELSVITDAREWRYFKEL 612

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1153 TETYTPVEENMFSGEAQNDLPgiQVFLRPKESINIPLKYQsfkadhsvhpqgpynphrplinmqmpeqnkvdlslqsrnt 1232
Cdd:cd22239   613 NNVTTPLEENMFHLNPDTLRP--QVFLRPKETVHIPFKYQ---------------------------------------- 650

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1233 kvyfktgddrpiailslniepqPQIVDQTFRFHHPEQSFLKKSVRLPPFQSLPGAPVGGAGLHGLFVRCSDPNVICESKR 1312
Cdd:cd22239   651 ----------------------PHVVDQTFRFYHPEQSFLKKSIRLPPFHTLPGAPVGPGGLRQVHVRCSDPNVICETRN 708

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1313 VAPGEPQDVFIKVACGASPAIKKFFIIIYGDQFLSRPVQTWQFYIHALQRVDVTCVEGQTSRFSLILRGTQSSRLtqcfs 1392
Cdd:cd22239   709 LTPGEPQDVFIKVASGPSPQIKKFFVLIYSDPYLARPIQIWQFYVHALQRVDVSCVEGQTSRFSLVLRGTQSSRV----- 783

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585681565 1393 shpiemqispvepfmllansvheihvgvrptsVGSKFMYINVVDTEYHQLVRSWLICVTCRQPVISKAFELQLPVGGGKG 1472
Cdd:cd22239   784 --------------------------------VGSKFLYVNVVDTETHQLVRSWLVCISCRQPVISKAFEIQLPVGGGKG 831

                        1450      1460      1470      1480      1490      1500      1510
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 585681565 1473 SNKRISYTNPYPYKKVFNLRSNRDDLLQFKETKIEIGAGQVHTIGLRFTPSQVPGSAEILIFINDAEDKNEET 1545
Cdd:cd22239   832 CNKRISYTNPYPNRKTFHLRTNRSDLLQFKETRLEVGAGETYTIGLRFAPSQTPGKEEILIFINDEEDKNEET 904
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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