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Conserved domains on  [gi|827057081|ref|XP_008090161|]
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secretory pathway protein Sec39 [Colletotrichum graminicola M1.001]

Protein Classification

secretory pathway Sec39 family protein( domain architecture ID 10550861)

secretory pathway Sec39 family protein may be required for protein transport between the Golgi and the endoplasmic reticulum

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Sec39 pfam08314
Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ...
11-779 0e+00

Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).


:

Pssm-ID: 429913  Cd Length: 725  Bit Score: 986.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081   11 VLLAVHLAIHADLDSLAFLSSRHAAVLRKDLVLRILLTYLPETVPSSDYVSFLEELANGEFAE---REAGNIDYAIAENI 87
Cdd:pfam08314   1 VLLAVHFASRADIDALSSLTSRFPDVLRKELLLRILLTYLPETLDPSEYTSLLQELASGSSDEpddLLEDDVDTSPVIEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081   88 SDEDAAKKVRKLHLLPLAWKDaPIEIGDDPMVLFLLKRAHRVDEEAGLLTQLPELLGPFLQYAPGIRTWMVSTLLPLLRR 167
Cdd:pfam08314  81 SEEEARKRVRKLRLLPLKIPD-PEDSPDDLLTSFLIHRALRIDPETGLLSLVLELVLPFLDRSPYLRTWIISTVLPLLRL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  168 NCEYYPASSIPYTLAEFQSLSDGAAVGALLSQTGArqEDHVFIGRDLRGMLVPWLHDDSRWKRVEKGDS-FGETVCSPGW 246
Cdd:pfam08314 160 NYEYYPDDSDTLSLEEFESLDDREAVNLLLSKTGS--DNGENVGRDLRGLVGPWLYGKNRWKRRRLNEDdPGDDETCPGW 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  247 ERFLEWLLAQSSNSWRVAVAAVEQWGGAVDVDLGDYDVVWISEEQQQYLDRRYARAIMAGAYLVPEATIDALEGAHQMLR 326
Cdd:pfam08314 238 EEVNEWLLSQAAKSWGVAVNAFEQWDGPEDVDLGGDGTDSLDEDEQQELERRYARAALAIIYLVPENSLEALEGAYRILS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  327 KVMDLLGqddtlslregadadvlppvayleggsvlshkntafmregLLKQSNPLTTPSKRSTHLLHALILSAFILTRAGL 406
Cdd:pfam08314 318 RLAELLD---------------------------------------LLTESNPLTTPSSESISLLQALLLSAYILTSLGH 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  407 PCTIKMAGDLAFIQDERDQKAEVVKLIHAIAERAPKNGDDFWAKARNEILWLRnwgitsppngQVMGVFAKVEPGVIETE 486
Cdd:pfam08314 359 PCSVREAADLILLGDEEEQLAELRKLLRSLSKQGPKTDDKDWIKLRNELLWLS----------SGQGVFGRLSREEIESE 428
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  487 ILKALLSSARYSLAKSLYEDAVVKPLSAQTVQETVIAAALNAYDNASNPNRTRGGLKKCDEIINAFPGTISSSLPERCRI 566
Cdd:pfam08314 429 ILKALLSNGRFDLAKEIYEDSPKQPLSSEQVEDVVLKAAWEAYDNASNGNRTRGGMKKADDILNAFPPTFPKSSPEFKRL 508
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  567 DSLLKATHALSDYRLVLRQGEPFSPVVLRVHSDPVSIIGKVLEQNPKGYTRIHDLLDVGSNMVRA-GIVDRSKREVAaqa 645
Cdd:pfam08314 509 EALLAATHALSFYSLTLQHGVPFKPVNIRVHSDPLSLISKVLEQNPKSYTKLDDLLEIGRNLVEAmGLTGRDSDSTP--- 585
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  646 iEDEEACVDTSTRRITAMCIEAALKEDDFETAYSYVVNRLSGQVGHSKTASR-VQIDDDWSWRAALQAGQYMRTVRTVRP 724
Cdd:pfam08314 586 -ESLEKERKSAERRITAMCIEAALVEDDFETAYSYVVNRLTPPSELPTSASKtNDELDDWSWRAALQAGKYRRPEDTEIP 664
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 827057081  725 THLGNASGnPDIRHLEQRIDCLATALRLAPPSQLQEILKTFRRCEEQLDSALKEE 779
Cdd:pfam08314 665 TEIGTASG-PEIRHLEQRMELLSQALRLAPPEELEEVLNAWRRCEEELSSLLAQE 718
 
Name Accession Description Interval E-value
Sec39 pfam08314
Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ...
11-779 0e+00

Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).


Pssm-ID: 429913  Cd Length: 725  Bit Score: 986.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081   11 VLLAVHLAIHADLDSLAFLSSRHAAVLRKDLVLRILLTYLPETVPSSDYVSFLEELANGEFAE---REAGNIDYAIAENI 87
Cdd:pfam08314   1 VLLAVHFASRADIDALSSLTSRFPDVLRKELLLRILLTYLPETLDPSEYTSLLQELASGSSDEpddLLEDDVDTSPVIEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081   88 SDEDAAKKVRKLHLLPLAWKDaPIEIGDDPMVLFLLKRAHRVDEEAGLLTQLPELLGPFLQYAPGIRTWMVSTLLPLLRR 167
Cdd:pfam08314  81 SEEEARKRVRKLRLLPLKIPD-PEDSPDDLLTSFLIHRALRIDPETGLLSLVLELVLPFLDRSPYLRTWIISTVLPLLRL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  168 NCEYYPASSIPYTLAEFQSLSDGAAVGALLSQTGArqEDHVFIGRDLRGMLVPWLHDDSRWKRVEKGDS-FGETVCSPGW 246
Cdd:pfam08314 160 NYEYYPDDSDTLSLEEFESLDDREAVNLLLSKTGS--DNGENVGRDLRGLVGPWLYGKNRWKRRRLNEDdPGDDETCPGW 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  247 ERFLEWLLAQSSNSWRVAVAAVEQWGGAVDVDLGDYDVVWISEEQQQYLDRRYARAIMAGAYLVPEATIDALEGAHQMLR 326
Cdd:pfam08314 238 EEVNEWLLSQAAKSWGVAVNAFEQWDGPEDVDLGGDGTDSLDEDEQQELERRYARAALAIIYLVPENSLEALEGAYRILS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  327 KVMDLLGqddtlslregadadvlppvayleggsvlshkntafmregLLKQSNPLTTPSKRSTHLLHALILSAFILTRAGL 406
Cdd:pfam08314 318 RLAELLD---------------------------------------LLTESNPLTTPSSESISLLQALLLSAYILTSLGH 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  407 PCTIKMAGDLAFIQDERDQKAEVVKLIHAIAERAPKNGDDFWAKARNEILWLRnwgitsppngQVMGVFAKVEPGVIETE 486
Cdd:pfam08314 359 PCSVREAADLILLGDEEEQLAELRKLLRSLSKQGPKTDDKDWIKLRNELLWLS----------SGQGVFGRLSREEIESE 428
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  487 ILKALLSSARYSLAKSLYEDAVVKPLSAQTVQETVIAAALNAYDNASNPNRTRGGLKKCDEIINAFPGTISSSLPERCRI 566
Cdd:pfam08314 429 ILKALLSNGRFDLAKEIYEDSPKQPLSSEQVEDVVLKAAWEAYDNASNGNRTRGGMKKADDILNAFPPTFPKSSPEFKRL 508
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  567 DSLLKATHALSDYRLVLRQGEPFSPVVLRVHSDPVSIIGKVLEQNPKGYTRIHDLLDVGSNMVRA-GIVDRSKREVAaqa 645
Cdd:pfam08314 509 EALLAATHALSFYSLTLQHGVPFKPVNIRVHSDPLSLISKVLEQNPKSYTKLDDLLEIGRNLVEAmGLTGRDSDSTP--- 585
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  646 iEDEEACVDTSTRRITAMCIEAALKEDDFETAYSYVVNRLSGQVGHSKTASR-VQIDDDWSWRAALQAGQYMRTVRTVRP 724
Cdd:pfam08314 586 -ESLEKERKSAERRITAMCIEAALVEDDFETAYSYVVNRLTPPSELPTSASKtNDELDDWSWRAALQAGKYRRPEDTEIP 664
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 827057081  725 THLGNASGnPDIRHLEQRIDCLATALRLAPPSQLQEILKTFRRCEEQLDSALKEE 779
Cdd:pfam08314 665 TEIGTASG-PEIRHLEQRMELLSQALRLAPPEELEEVLNAWRRCEEELSSLLAQE 718
 
Name Accession Description Interval E-value
Sec39 pfam08314
Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ...
11-779 0e+00

Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).


Pssm-ID: 429913  Cd Length: 725  Bit Score: 986.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081   11 VLLAVHLAIHADLDSLAFLSSRHAAVLRKDLVLRILLTYLPETVPSSDYVSFLEELANGEFAE---REAGNIDYAIAENI 87
Cdd:pfam08314   1 VLLAVHFASRADIDALSSLTSRFPDVLRKELLLRILLTYLPETLDPSEYTSLLQELASGSSDEpddLLEDDVDTSPVIEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081   88 SDEDAAKKVRKLHLLPLAWKDaPIEIGDDPMVLFLLKRAHRVDEEAGLLTQLPELLGPFLQYAPGIRTWMVSTLLPLLRR 167
Cdd:pfam08314  81 SEEEARKRVRKLRLLPLKIPD-PEDSPDDLLTSFLIHRALRIDPETGLLSLVLELVLPFLDRSPYLRTWIISTVLPLLRL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  168 NCEYYPASSIPYTLAEFQSLSDGAAVGALLSQTGArqEDHVFIGRDLRGMLVPWLHDDSRWKRVEKGDS-FGETVCSPGW 246
Cdd:pfam08314 160 NYEYYPDDSDTLSLEEFESLDDREAVNLLLSKTGS--DNGENVGRDLRGLVGPWLYGKNRWKRRRLNEDdPGDDETCPGW 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  247 ERFLEWLLAQSSNSWRVAVAAVEQWGGAVDVDLGDYDVVWISEEQQQYLDRRYARAIMAGAYLVPEATIDALEGAHQMLR 326
Cdd:pfam08314 238 EEVNEWLLSQAAKSWGVAVNAFEQWDGPEDVDLGGDGTDSLDEDEQQELERRYARAALAIIYLVPENSLEALEGAYRILS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  327 KVMDLLGqddtlslregadadvlppvayleggsvlshkntafmregLLKQSNPLTTPSKRSTHLLHALILSAFILTRAGL 406
Cdd:pfam08314 318 RLAELLD---------------------------------------LLTESNPLTTPSSESISLLQALLLSAYILTSLGH 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  407 PCTIKMAGDLAFIQDERDQKAEVVKLIHAIAERAPKNGDDFWAKARNEILWLRnwgitsppngQVMGVFAKVEPGVIETE 486
Cdd:pfam08314 359 PCSVREAADLILLGDEEEQLAELRKLLRSLSKQGPKTDDKDWIKLRNELLWLS----------SGQGVFGRLSREEIESE 428
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  487 ILKALLSSARYSLAKSLYEDAVVKPLSAQTVQETVIAAALNAYDNASNPNRTRGGLKKCDEIINAFPGTISSSLPERCRI 566
Cdd:pfam08314 429 ILKALLSNGRFDLAKEIYEDSPKQPLSSEQVEDVVLKAAWEAYDNASNGNRTRGGMKKADDILNAFPPTFPKSSPEFKRL 508
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  567 DSLLKATHALSDYRLVLRQGEPFSPVVLRVHSDPVSIIGKVLEQNPKGYTRIHDLLDVGSNMVRA-GIVDRSKREVAaqa 645
Cdd:pfam08314 509 EALLAATHALSFYSLTLQHGVPFKPVNIRVHSDPLSLISKVLEQNPKSYTKLDDLLEIGRNLVEAmGLTGRDSDSTP--- 585
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827057081  646 iEDEEACVDTSTRRITAMCIEAALKEDDFETAYSYVVNRLSGQVGHSKTASR-VQIDDDWSWRAALQAGQYMRTVRTVRP 724
Cdd:pfam08314 586 -ESLEKERKSAERRITAMCIEAALVEDDFETAYSYVVNRLTPPSELPTSASKtNDELDDWSWRAALQAGKYRRPEDTEIP 664
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 827057081  725 THLGNASGnPDIRHLEQRIDCLATALRLAPPSQLQEILKTFRRCEEQLDSALKEE 779
Cdd:pfam08314 665 TEIGTASG-PEIRHLEQRMELLSQALRLAPPEELEEVLNAWRRCEEELSSLLAQE 718
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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