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Conserved domains on  [gi|672052774|ref|XP_008761977|]
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tenascin isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1890-2099 9.92e-114

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 359.91  E-value: 9.92e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1890 FPRDCSQAMLNGDTTSGLYTIYINGDKTQaLEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGD-RREEFWLGL 1968
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGATKP-FEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1969 DNLSKITAQGQYELRVDLQDH-GESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-------SMNYHNGRSFSTYDKDTD 2040
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672052774  2041 SAITNCALSYKGAFWYKNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEYSIQFAEMKLRPS 2099
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
822-1234 7.05e-21

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 99.69  E-value: 7.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  822 TWSKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQ---YSIGNLKPDTEYEVSLISRRVDMASNPAKE----TFITGLD 894
Cdd:COG3401   155 ASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTtlvDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPS 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  895 APRNLRRVSQTDNSITLEWRNVKA-DIDSYRIKYAPISGGDHAEIdvpksqqATTKTTL---TGLRPGTEYGVGVSAVKG 970
Cdd:COG3401   235 APTGLTATADTPGSVTLSWDPVTEsDATGYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDA 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  971 D-KEGDPATINAATEI----DAPRDLQVSETTQDSLTLFW-KTPLAKFDRYRLNYS-LPTGQSIEIQLPKDATSHVLTDL 1043
Cdd:COG3401   308 AgNESAPSNVVSVTTDltppAAPSGLTATAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGL 387

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1044 EPGQEYTVLLTA--EKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLR-LNWTADDLAYEYFVIQVQEANKVETAHNF 1120
Cdd:COG3401   388 TPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNA 467

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1121 TVLGNLRTADIPGLKAATPYRVSIYGVARGYKTpvlSAETFTGKTPSLGEVTVAEVGWDalkLNWTAPEGAYTNFFIQVL 1200
Cdd:COG3401   468 VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGS---GASSVTNSVSVIGASAAAAVGGA---PDGTPNVTGASPVTVGAS 541

                         410       420       430
                  ....*....|....*....|....*....|....
gi 672052774 1201 EADMTQTVQNLTVPGGLRSVDLPGLKAATRYYIT 1234
Cdd:COG3401   542 TGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
fn3 pfam00041
Fibronectin type III domain;
1798-1870 6.68e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 71.68  E-value: 6.68e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672052774  1798 DSPRELTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTARIQALSG 1870
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1628-1867 5.34e-13

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 74.27  E-value: 5.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1628 FSDITENAATVSWRAPTAQVESFRITYVPVTGGPPS-MVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFEESDPVSG--- 1703
Cdd:COG3401   147 LYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsv 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1704 -SLITALDGPSGLLTANITDSEALAMWQPAIAT-VDSYVISYTGERVPEITRTVSGNTVEFELHDLEPATEYTLSVFAEK 1781
Cdd:COG3401   227 tTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVD 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1782 GH----QKSSTI-ATKFTTDLDSPRELTATEVQSETALLTWRPPRAS-VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLA 1853
Cdd:COG3401   307 AAgnesAPSNVVsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VYrsTSGGGTYTKIAETVTTTSYTDT 385

                         250
                  ....*....|....
gi 672052774 1854 DLSPSTHYTARIQA 1867
Cdd:COG3401   386 GLTPGTTYYYKVTA 399
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 5.94e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.37  E-value: 5.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENK 699
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 672052774  700 RSIPVSARVAT 710
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1531-1611 3.56e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1531 PEVDNLLVSDATPDGFRLSWTADE---GIFDSFVIRIRDTKKQSEPQEITLPSPDRTRDITGLREATEYEIELYGISRGR 1607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 672052774  1608 RSQP 1611
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
713-793 7.84e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 7.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 672052774   790 TRGP 793
Cdd:pfam00041   80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
1443-1515 9.08e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 9.08e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774  1443 ENLTISDTNPYGFTVSWTASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVLVSGFTQG 1515
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1257-1326 9.37e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 9.37e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672052774  1257 PEIGNLNISDVTPESFNLSWTA---TDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIVYL 1326
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
fn3 pfam00041
Fibronectin type III domain;
1346-1418 5.13e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 5.13e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774  1346 PEPQLgmLIFSNITPDSFHVSWT---TQAGLFAKIVINVRDAHSLHESRQITVPGDAQQAHITGLVENTAYDVSVT 1418
Cdd:pfam00041    1 SAPSN--LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 1.22e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 46.52  E-value: 1.22e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 8.09e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 44.21  E-value: 8.09e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   190 CPGNCNLRGQCLDGQCICDQGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 8.41e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 44.21  E-value: 8.41e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   501 CPRDCSQRGRCVDGQCICEDGFTGSDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 1.58e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 40.74  E-value: 1.58e-04
                           10        20
                   ....*....|....*....|....*..
gi 672052774   470 CPNDCHQHGRCVNGMCICDDDYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 4.47e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.20  E-value: 4.47e-04
                           10        20
                   ....*....|....*....|....*...
gi 672052774   594 CPNDCSNQGQCVAGRCICNEGYTGVDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 8.73e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 8.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 672052774   380 DCHHHGRC--LNGQCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 9.82e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 9.82e-04
                           10        20
                   ....*....|....*....|....*.
gi 672052774   535 DCHGHGRCVN--GQCICHEGFTGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 350-372 1.70e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.70e-03
                           10        20
                   ....*....|....*....|....*
gi 672052774   350 CQGHGQCE--EGQCVCNEGFAGADC 372
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 1.88e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.66  E-value: 1.88e-03
                           10        20
                   ....*....|....*....|....*...
gi 672052774   439 CPNDCHNRGHCVQGKCICEQGFKGFDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 3.39e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 36.89  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|....*....
gi 672052774   252 CPVPCSEEhGMCVDGRCVCKDGFAGEDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 3.66e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 36.89  E-value: 3.66e-03
                           10        20
                   ....*....|....*....|....*...
gi 672052774   284 CFNNCNNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 8.71e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 35.74  E-value: 8.71e-03
                           10        20
                   ....*....|....*....|....*..
gi 672052774   563 CPSDCHGQGRCEDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1890-2099 9.92e-114

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 359.91  E-value: 9.92e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1890 FPRDCSQAMLNGDTTSGLYTIYINGDKTQaLEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGD-RREEFWLGL 1968
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGATKP-FEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1969 DNLSKITAQGQYELRVDLQDH-GESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-------SMNYHNGRSFSTYDKDTD 2040
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672052774  2041 SAITNCALSYKGAFWYKNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEYSIQFAEMKLRPS 2099
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1890-2098 3.47e-110

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 349.27  E-value: 3.47e-110
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1890 FPRDCSQAMLNGDTTSGLYTIYINGDkTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLD 1969
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1970 NLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-SMNYHNGRSFSTYDKDTDSAITNCA 2047
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 672052774   2048 LSYKGAFWYKNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEYSIQFAEMKLRP 2098
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1889-2098 8.85e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 348.46  E-value: 8.85e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1889 PFPRDCSQAMLNGDTTSGLYTIYINGDKtQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGL 1968
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1969 DNLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCA 2047
Cdd:cd00087    80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 672052774 2048 LSYKGAFWYKNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEYSIQFAEMKLRP 2098
Cdd:cd00087   160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
822-1234 7.05e-21

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 99.69  E-value: 7.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  822 TWSKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQ---YSIGNLKPDTEYEVSLISRRVDMASNPAKE----TFITGLD 894
Cdd:COG3401   155 ASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTtlvDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPS 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  895 APRNLRRVSQTDNSITLEWRNVKA-DIDSYRIKYAPISGGDHAEIdvpksqqATTKTTL---TGLRPGTEYGVGVSAVKG 970
Cdd:COG3401   235 APTGLTATADTPGSVTLSWDPVTEsDATGYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDA 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  971 D-KEGDPATINAATEI----DAPRDLQVSETTQDSLTLFW-KTPLAKFDRYRLNYS-LPTGQSIEIQLPKDATSHVLTDL 1043
Cdd:COG3401   308 AgNESAPSNVVSVTTDltppAAPSGLTATAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGL 387

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1044 EPGQEYTVLLTA--EKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLR-LNWTADDLAYEYFVIQVQEANKVETAHNF 1120
Cdd:COG3401   388 TPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNA 467

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1121 TVLGNLRTADIPGLKAATPYRVSIYGVARGYKTpvlSAETFTGKTPSLGEVTVAEVGWDalkLNWTAPEGAYTNFFIQVL 1200
Cdd:COG3401   468 VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGS---GASSVTNSVSVIGASAAAAVGGA---PDGTPNVTGASPVTVGAS 541

                         410       420       430
                  ....*....|....*....|....*....|....
gi 672052774 1201 EADMTQTVQNLTVPGGLRSVDLPGLKAATRYYIT 1234
Cdd:COG3401   542 TGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
fn3 pfam00041
Fibronectin type III domain;
894-976 1.66e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.60  E-value: 1.66e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   894 DAPRNLRRVSQTDNSITLEW---RNVKADIDSYRIKYAPISGGDHA-EIDVPKSqqaTTKTTLTGLRPGTEYGVGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 672052774   970 GDKEGDP 976
Cdd:pfam00041   78 GGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1798-1870 6.68e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 71.68  E-value: 6.68e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672052774  1798 DSPRELTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTARIQALSG 1870
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 2.22e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 2.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  894 DAPRNLRRVSQTDNSITLEWRNVKAD---IDSYRIKYAPISGGDHAEIDVPKSQqaTTKTTLTGLRPGTEYGVGVSAVKG 970
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                  ....*...
gi 672052774  971 DKEGDPAT 978
Cdd:cd00063    80 GGESPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1628-1867 5.34e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 74.27  E-value: 5.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1628 FSDITENAATVSWRAPTAQVESFRITYVPVTGGPPS-MVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFEESDPVSG--- 1703
Cdd:COG3401   147 LYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsv 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1704 -SLITALDGPSGLLTANITDSEALAMWQPAIAT-VDSYVISYTGERVPEITRTVSGNTVEFELHDLEPATEYTLSVFAEK 1781
Cdd:COG3401   227 tTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVD 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1782 GH----QKSSTI-ATKFTTDLDSPRELTATEVQSETALLTWRPPRAS-VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLA 1853
Cdd:COG3401   307 AAgnesAPSNVVsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VYrsTSGGGTYTKIAETVTTTSYTDT 385

                         250
                  ....*....|....
gi 672052774 1854 DLSPSTHYTARIQA 1867
Cdd:COG3401   386 GLTPGTTYYYKVTA 399
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 5.94e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.37  E-value: 5.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENK 699
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 672052774  700 RSIPVSARVAT 710
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1798-1870 8.83e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 8.83e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672052774   1798 DSPRELTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTARIQALSG 1870
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
fn3 pfam00041
Fibronectin type III domain;
1531-1611 3.56e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1531 PEVDNLLVSDATPDGFRLSWTADE---GIFDSFVIRIRDTKKQSEPQEITLPSPDRTRDITGLREATEYEIELYGISRGR 1607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 672052774  1608 RSQP 1611
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1621-1707 4.59e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 4.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1621 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPVTGGPPSMVTV-DGTDTETRLVRLTPGVEYHVSVIAMKGFE 1696
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 672052774 1697 ESDPVSGSLIT 1707
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
638-997 6.70e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.80  E-value: 6.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  638 TVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENKRSIP---VSARVATYLP- 713
Cdd:COG3401   155 ASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPs 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  714 APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNT 790
Cdd:COG3401   235 APTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNE 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  791 RGP-GLKKVTT--TRLDAPSQIEVRDITDTTALITWSKPLaeiDSIELSYGI---KDVPGDRTTIDLTHEDNQYSIGNLK 864
Cdd:COG3401   312 SAPsNVVSVTTdlTPPAAPSGLTATAVGSSSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLT 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  865 PDTEYEVSLISRRVD-MASNPAKETFITGLDAPRNL---RRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDV 940
Cdd:COG3401   389 PGTTYYYKVTAVDAAgNESAPSEEVSATTASAASGEsltASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAV 468

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 672052774  941 PKSQQATTKTTLTGLRPGTEYGVGVSAVKGD--KEGDPATINAATEIDAPRDLQVSETT 997
Cdd:COG3401   469 PFTTTSSTVTATTTDTTTANLSVTTGSLVGGsgASSVTNSVSVIGASAAAAVGGAPDGT 527
fn3 pfam00041
Fibronectin type III domain;
713-793 7.84e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 7.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 672052774   790 TRGP 793
Cdd:pfam00041   80 GEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1798-1883 1.06e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1798 DSPRELTATEVQSETALLTWRPPR---ASVTGYLLVYESVD-GTVKEVIVGP-DTTSYSLADLSPSTHYTARIQALSGSL 1872
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 672052774 1873 RSKLIQTI-FTT 1883
Cdd:cd00063    82 ESPPSESVtVTT 93
fn3 pfam00041
Fibronectin type III domain;
624-695 1.35e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 1.35e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774   624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1621-1700 2.16e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1621 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPV-TGGPPSMVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFE 1696
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKnSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 672052774  1697 ESDP 1700
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 2.53e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 2.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  624 SPPKDLIVTEVTEETVNLAWD--NEMRVTEYLImYTPTHADGlemQFRVPGDQTSTTI--RELEPGVEYFIHVFAILENK 699
Cdd:COG3401   234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRV-YRSNSGDG---PFTKVATVTTTSYtdTGLTNGTTYYYRVTAVDAAG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  700 R----SIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGL 773
Cdd:COG3401   310 NesapSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGL 387


                  ....*.
gi 672052774  774 APGQEY 779
Cdd:COG3401   388 TPGTTY 393
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 2.71e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.71e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774    986 DAPRDLQVSETTQDSLTLFWKTP-----LAKFDRYRLNYSLPTGQSIEIQLPKDATSHVLTDLEPGQEYTVLLTAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774   1061 KS 1062
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-701 8.93e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 8.93e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774    624 SPPKDLIVTEVTEETVNLAWD--NEMRVTEYLIMYTPTH--ADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENK 699
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEppPDDGITGYIVGYRVEYreEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774    700 RS 701
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1443-1515 9.08e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 9.08e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774  1443 ENLTISDTNPYGFTVSWTASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVLVSGFTQG 1515
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1533-1618 1.18e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1533 VDNLLVSDATPDGFRLSWTA---DEGIFDSFVIRIRDtKKQSEPQEITLPSPDRTR-DITGLREATEYEIELYGISRGRR 1608
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|
gi 672052774 1609 SQPVSAIATT 1618
Cdd:cd00063    83 SPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1621-1698 2.61e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.61e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1621 GSPKEIMFSDITENAATVSWRAPT-AQVESFRITYVPVTGGPPS---MVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFE 1696
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774   1697 ES 1698
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1257-1326 9.37e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 9.37e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672052774  1257 PEIGNLNISDVTPESFNLSWTA---TDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIVYL 1326
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1900-1933 1.22e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.56  E-value: 1.22e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 672052774 1900 NGDTTSGLYTIYINGD-KTQALEVYCDMTSDGGGW 1933
Cdd:NF040941    9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
fn3 pfam00041
Fibronectin type III domain;
1346-1418 5.13e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 5.13e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774  1346 PEPQLgmLIFSNITPDSFHVSWT---TQAGLFAKIVINVRDAHSLHESRQITVPGDAQQAHITGLVENTAYDVSVT 1418
Cdd:pfam00041    1 SAPSN--LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 2.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|..
gi 672052774  790 TRGPGLKKVTTT 801
Cdd:cd00063    81 GESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 2.90e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 2.90e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774    713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 672052774    791 RGPG 794
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1531-1609 8.10e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 8.10e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1531 PEVDNLLVSDATPDGFRLSWTA-DEGIFDSFVIRIRDTKKQSEPQEITLPSPDRTR--DITGLREATEYEIELYGISRGR 1607
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsyTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774   1608 RS 1609
Cdd:smart00060   82 EG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 1.22e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 46.52  E-value: 1.22e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1353-1425 5.60e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 5.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774 1353 LIFSNITPDSFHVSWTTQAGLFAKI---VINVRDAHSLHESRQITVPGDAQQAHITGLVENTAYDVSVTGTTWAGD 1425
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 8.09e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.21  E-value: 8.09e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   190 CPGNCNLRGQCLDGQCICDQGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 8.41e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.21  E-value: 8.41e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   501 CPRDCSQRGRCVDGQCICEDGFTGSDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1353-1425 2.00e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 2.00e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774   1353 LIFSNITPDSFHVSWT--TQAGLFAKIV-INVRDAHSLHESRQITVPGDAQQAHITGLVENTAYDVSVTGTTWAGD 1425
Cdd:smart00060    7 LRVTDVTSTSVTLSWEppPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 1.58e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.74  E-value: 1.58e-04
                           10        20
                   ....*....|....*....|....*..
gi 672052774   470 CPNDCHQHGRCVNGMCICDDDYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 4.47e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.20  E-value: 4.47e-04
                           10        20
                   ....*....|....*....|....*...
gi 672052774   594 CPNDCSNQGQCVAGRCICNEGYTGVDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1443-1527 5.72e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1443 ENLTISDTNPYGFTVSWTASEN---AFDSFLVTVVDSGKLlDPQEF-TLSGTQRKLELRGLITGIGYEVLVSGFTQGHQT 1518
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSG-DWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....*....
gi 672052774 1519 KPLRAETIT 1527
Cdd:cd00063    84 PPSESVTVT 92
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 8.73e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 8.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 672052774   380 DCHHHGRC--LNGQCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 9.82e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 9.82e-04
                           10        20
                   ....*....|....*....|....*.
gi 672052774   535 DCHGHGRCVN--GQCICHEGFTGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 350-372 1.70e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.70e-03
                           10        20
                   ....*....|....*....|....*
gi 672052774   350 CQGHGQCE--EGQCVCNEGFAGADC 372
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 1.88e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 1.88e-03
                           10        20
                   ....*....|....*....|....*...
gi 672052774   439 CPNDCHNRGHCVQGKCICEQGFKGFDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 3.39e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|....*....
gi 672052774   252 CPVPCSEEhGMCVDGRCVCKDGFAGEDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 3.66e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 3.66e-03
                           10        20
                   ....*....|....*....|....*...
gi 672052774   284 CFNNCNNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-434 3.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.96e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 672052774  409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054     8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 526-559 4.07e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 672052774  526 DCAElscPGDCHGHGRCVNG----QCICHEGFTGKDCK 559
Cdd:cd00054     4 ECAS---GNPCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1260-1324 5.62e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 5.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672052774 1260 GNLNISDVTPESFNLSWTA---TDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIV 1324
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 8.71e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 35.74  E-value: 8.71e-03
                           10        20
                   ....*....|....*....|....*..
gi 672052774   563 CPSDCHGQGRCEDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1890-2099 9.92e-114

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 359.91  E-value: 9.92e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1890 FPRDCSQAMLNGDTTSGLYTIYINGDKTQaLEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGD-RREEFWLGL 1968
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGATKP-FEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1969 DNLSKITAQGQYELRVDLQDH-GESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-------SMNYHNGRSFSTYDKDTD 2040
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672052774  2041 SAITNCALSYKGAFWYKNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEYSIQFAEMKLRPS 2099
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1890-2098 3.47e-110

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 349.27  E-value: 3.47e-110
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1890 FPRDCSQAMLNGDTTSGLYTIYINGDkTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLD 1969
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1970 NLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-SMNYHNGRSFSTYDKDTDSAITNCA 2047
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 672052774   2048 LSYKGAFWYKNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEYSIQFAEMKLRP 2098
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1889-2098 8.85e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 348.46  E-value: 8.85e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1889 PFPRDCSQAMLNGDTTSGLYTIYINGDKtQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGL 1968
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1969 DNLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCA 2047
Cdd:cd00087    80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 672052774 2048 LSYKGAFWYKNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEYSIQFAEMKLRP 2098
Cdd:cd00087   160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
822-1234 7.05e-21

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 99.69  E-value: 7.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  822 TWSKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQ---YSIGNLKPDTEYEVSLISRRVDMASNPAKE----TFITGLD 894
Cdd:COG3401   155 ASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTtlvDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPS 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  895 APRNLRRVSQTDNSITLEWRNVKA-DIDSYRIKYAPISGGDHAEIdvpksqqATTKTTL---TGLRPGTEYGVGVSAVKG 970
Cdd:COG3401   235 APTGLTATADTPGSVTLSWDPVTEsDATGYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDA 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  971 D-KEGDPATINAATEI----DAPRDLQVSETTQDSLTLFW-KTPLAKFDRYRLNYS-LPTGQSIEIQLPKDATSHVLTDL 1043
Cdd:COG3401   308 AgNESAPSNVVSVTTDltppAAPSGLTATAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGL 387

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1044 EPGQEYTVLLTA--EKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLR-LNWTADDLAYEYFVIQVQEANKVETAHNF 1120
Cdd:COG3401   388 TPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNA 467

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1121 TVLGNLRTADIPGLKAATPYRVSIYGVARGYKTpvlSAETFTGKTPSLGEVTVAEVGWDalkLNWTAPEGAYTNFFIQVL 1200
Cdd:COG3401   468 VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGS---GASSVTNSVSVIGASAAAAVGGA---PDGTPNVTGASPVTVGAS 541

                         410       420       430
                  ....*....|....*....|....*....|....
gi 672052774 1201 EADMTQTVQNLTVPGGLRSVDLPGLKAATRYYIT 1234
Cdd:COG3401   542 TGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
fn3 pfam00041
Fibronectin type III domain;
894-976 1.66e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.60  E-value: 1.66e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   894 DAPRNLRRVSQTDNSITLEW---RNVKADIDSYRIKYAPISGGDHA-EIDVPKSqqaTTKTTLTGLRPGTEYGVGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 672052774   970 GDKEGDP 976
Cdd:pfam00041   78 GGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1798-1870 6.68e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 71.68  E-value: 6.68e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672052774  1798 DSPRELTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTARIQALSG 1870
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 2.22e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 2.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  894 DAPRNLRRVSQTDNSITLEWRNVKAD---IDSYRIKYAPISGGDHAEIDVPKSQqaTTKTTLTGLRPGTEYGVGVSAVKG 970
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                  ....*...
gi 672052774  971 DKEGDPAT 978
Cdd:cd00063    80 GGESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
986-1064 4.50e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.67  E-value: 4.50e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   986 DAPRDLQVSETTQDSLTLFWKTPL---AKFDRYRLNYSLPTGQS--IEIQLPKDATSHVLTDLEPGQEYTVLLTAEKGRH 1060
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 672052774  1061 KSKP 1064
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1628-1867 5.34e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 74.27  E-value: 5.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1628 FSDITENAATVSWRAPTAQVESFRITYVPVTGGPPS-MVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFEESDPVSG--- 1703
Cdd:COG3401   147 LYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsv 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1704 -SLITALDGPSGLLTANITDSEALAMWQPAIAT-VDSYVISYTGERVPEITRTVSGNTVEFELHDLEPATEYTLSVFAEK 1781
Cdd:COG3401   227 tTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVD 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1782 GH----QKSSTI-ATKFTTDLDSPRELTATEVQSETALLTWRPPRAS-VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLA 1853
Cdd:COG3401   307 AAgnesAPSNVVsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VYrsTSGGGTYTKIAETVTTTSYTDT 385

                         250
                  ....*....|....
gi 672052774 1854 DLSPSTHYTARIQA 1867
Cdd:COG3401   386 GLTPGTTYYYKVTA 399
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 5.94e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.37  E-value: 5.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENK 699
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 672052774  700 RSIPVSARVAT 710
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1798-1870 8.83e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 8.83e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672052774   1798 DSPRELTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTARIQALSG 1870
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1405-1889 1.14e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.11  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1405 TGLVENTAYDVSVTGTTWAGDPTRPLTAFVITEALPL-LENLTISDTNPYGFTVSWTASENAFDSFLVTVVDSGKlldpq 1483
Cdd:COG3401   109 TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAgLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT----- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1484 EFTLSGTQRKLELRGLITGIGYEVLVSGFTQGHQTKP---LRAETITEAEPEVDNLLVSDATPDGFRLSWTA--DEGIfD 1558
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtESDA-T 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1559 SFVIRiRDTKKQSEPQEITLPSPDRTRDiTGLREATEYEielYGIS----RGRRSQPVSAIATTAMGS----PKEIMFSD 1630
Cdd:COG3401   263 GYRVY-RSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYY---YRVTavdaAGNESAPSNVVSVTTDLTppaaPSGLTATA 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1631 ITENAATVSWRAPT-AQVESFRITYVPVTGGPPSMVTVDGTDTETRLVRLTPGVEYHVSVIAM----KGFEESDPVSGSL 1705
Cdd:COG3401   338 VGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATT 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1706 ITALDGPSGLLTANITDSEALAMWQPAIATVDSYVISYTGERVPEITRTVSGNTVEFELHDLEPATEYTLSVFAEKGHQK 1785
Cdd:COG3401   418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1786 SSTIAtkfTTDLDSPRELTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTARI 1865
Cdd:COG3401   498 GGSGA---SSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLI 574

                         490       500
                  ....*....|....*....|....
gi 672052774 1866 QALSGSLRSKLIQTIFTTIGLLYP 1889
Cdd:COG3401   575 TTLGGSLLTTTSTNTNDVAGVHGG 598
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 986-1065 3.36e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 3.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  986 DAPRDLQVSETTQDSLTLFWKTPL---AKFDRYRLNYS-LPTGQSIEIQL-PKDATSHVLTDLEPGQEYTVLLTAEKGRH 1060
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 672052774 1061 KSKPA 1065
Cdd:cd00063    82 ESPPS 86
fn3 pfam00041
Fibronectin type III domain;
1531-1611 3.56e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1531 PEVDNLLVSDATPDGFRLSWTADE---GIFDSFVIRIRDTKKQSEPQEITLPSPDRTRDITGLREATEYEIELYGISRGR 1607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 672052774  1608 RSQP 1611
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1621-1707 4.59e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 4.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1621 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPVTGGPPSMVTV-DGTDTETRLVRLTPGVEYHVSVIAMKGFE 1696
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 672052774 1697 ESDPVSGSLIT 1707
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
638-997 6.70e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.80  E-value: 6.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  638 TVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENKRSIP---VSARVATYLP- 713
Cdd:COG3401   155 ASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPs 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  714 APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNT 790
Cdd:COG3401   235 APTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNE 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  791 RGP-GLKKVTT--TRLDAPSQIEVRDITDTTALITWSKPLaeiDSIELSYGI---KDVPGDRTTIDLTHEDNQYSIGNLK 864
Cdd:COG3401   312 SAPsNVVSVTTdlTPPAAPSGLTATAVGSSSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLT 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  865 PDTEYEVSLISRRVD-MASNPAKETFITGLDAPRNL---RRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDV 940
Cdd:COG3401   389 PGTTYYYKVTAVDAAgNESAPSEEVSATTASAASGEsltASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAV 468

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 672052774  941 PKSQQATTKTTLTGLRPGTEYGVGVSAVKGD--KEGDPATINAATEIDAPRDLQVSETT 997
Cdd:COG3401   469 PFTTTSSTVTATTTDTTTANLSVTTGSLVGGsgASSVTNSVSVIGASAAAAVGGAPDGT 527
fn3 pfam00041
Fibronectin type III domain;
713-793 7.84e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 7.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 672052774   790 TRGP 793
Cdd:pfam00041   80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
1166-1241 9.91e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 9.91e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672052774  1166 PSLGEVTVAEVGWDALKLNWTAPE---GAYTNFFIQVLEADMTQTVQNLTVPGGLRSVDLPGLKAATRYYITVRGVTQD 1241
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1798-1883 1.06e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1798 DSPRELTATEVQSETALLTWRPPR---ASVTGYLLVYESVD-GTVKEVIVGP-DTTSYSLADLSPSTHYTARIQALSGSL 1872
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 672052774 1873 RSKLIQTI-FTT 1883
Cdd:cd00063    82 ESPPSESVtVTT 93
fn3 pfam00041
Fibronectin type III domain;
624-695 1.35e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 1.35e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774   624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1621-1700 2.16e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1621 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPV-TGGPPSMVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFE 1696
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKnSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 672052774  1697 ESDP 1700
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 2.53e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 2.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  624 SPPKDLIVTEVTEETVNLAWD--NEMRVTEYLImYTPTHADGlemQFRVPGDQTSTTI--RELEPGVEYFIHVFAILENK 699
Cdd:COG3401   234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRV-YRSNSGDG---PFTKVATVTTTSYtdTGLTNGTTYYYRVTAVDAAG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  700 R----SIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGL 773
Cdd:COG3401   310 NesapSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGL 387


                  ....*.
gi 672052774  774 APGQEY 779
Cdd:COG3401   388 TPGTTY 393
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 2.71e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.71e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774    986 DAPRDLQVSETTQDSLTLFWKTP-----LAKFDRYRLNYSLPTGQSIEIQLPKDATSHVLTDLEPGQEYTVLLTAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774   1061 KS 1062
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1075-1154 3.13e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 3.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1075 PSLENLTVTEAGWDGLRLNWTADDL---AYEYFVIQVQEANKVETAHNFTVLGNLRTADIPGLKAATPYRVSIYGVARGY 1151
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 672052774  1152 KTP 1154
Cdd:pfam00041   81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-891 2.06e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 2.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  804 DAPSQIEVRDITDTTALITWSKPL---AEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLKPDTEYEVSLISRRVDM 880
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 672052774  881 ASNPAKETFIT 891
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 894-974 2.44e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 2.44e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774    894 DAPRNLRRVSQTDNSITLEWRNVKAD-IDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGVGVSAVKGDK 972
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774    973 EG 974
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
804-884 3.92e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 3.92e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   804 DAPSQIEVRDITDTTALITWSKPL---AEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLKPDTEYEVSLISRRVDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 672052774   881 ASNP 884
Cdd:pfam00041   81 EGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-701 8.93e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 8.93e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774    624 SPPKDLIVTEVTEETVNLAWD--NEMRVTEYLIMYTPTH--ADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENK 699
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEppPDDGITGYIVGYRVEYreEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774    700 RS 701
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1443-1515 9.08e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 9.08e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774  1443 ENLTISDTNPYGFTVSWTASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVLVSGFTQG 1515
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-876 1.01e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.01e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774    804 DAPSQIEVRDITDTTALITWSKPLAE-IDSIELSYGIKDVPGDR--TTIDLTHEDNQYSIGNLKPDTEYEVSLISR 876
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1533-1618 1.18e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1533 VDNLLVSDATPDGFRLSWTA---DEGIFDSFVIRIRDtKKQSEPQEITLPSPDRTR-DITGLREATEYEIELYGISRGRR 1608
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|
gi 672052774 1609 SQPVSAIATT 1618
Cdd:cd00063    83 SPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1621-1698 2.61e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.61e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1621 GSPKEIMFSDITENAATVSWRAPT-AQVESFRITYVPVTGGPPS---MVTVDGTDTETRLVRLTPGVEYHVSVIAMKGFE 1696
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774   1697 ES 1698
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1608-1871 5.52e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.17  E-value: 5.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1608 RSQPVSAIATTAMGSPKEIMFSDITENAATVSW---RAPTAQVESFRITYVPVTGGPPSMVTVDGTDTETRLVRLTPGVE 1684
Cdd:COG3401    37 LVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTggrAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1685 YHVSVIAMKGFEESDPVSGSLITALDGPSGLLTANITDSEALAMWQPAIATVDSYVISYTGERVPEITRTVSGNTVEFEL 1764
Cdd:COG3401   117 VPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGG 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1765 HDLEPATEYTLSVFAEKGHQKSST----IATKFTTDLDSPRELTATEVQSETALLTWRP-PRASVTGYLLVYESVDGTVK 1839
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPsnevSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPF 276

                         250       260       270
                  ....*....|....*....|....*....|..
gi 672052774 1840 EVIVGPDTTSYSLADLSPSTHYTARIQALSGS 1871
Cdd:COG3401   277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308
fn3 pfam00041
Fibronectin type III domain;
1712-1786 7.48e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 7.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  1712 PSGLLTANITDSEALAMWQPA---IATVDSYVISY--TGERVPEITRTVSGNTVEFELHDLEPATEYTLSVFAEKGHQKS 1786
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
fn3 pfam00041
Fibronectin type III domain;
1257-1326 9.37e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 9.37e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672052774  1257 PEIGNLNISDVTPESFNLSWTA---TDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIVYL 1326
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1900-1933 1.22e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.56  E-value: 1.22e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 672052774 1900 NGDTTSGLYTIYINGD-KTQALEVYCDMTSDGGGW 1933
Cdd:NF040941    9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
fn3 pfam00041
Fibronectin type III domain;
1346-1418 5.13e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 5.13e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774  1346 PEPQLgmLIFSNITPDSFHVSWT---TQAGLFAKIVINVRDAHSLHESRQITVPGDAQQAHITGLVENTAYDVSVT 1418
Cdd:pfam00041    1 SAPSN--LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
798-1216 1.26e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 57.26  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  798 VTTTRLDAPSQIEVRDITDTTALITWSKPLAEID-SIELSYGIKDVPGDRTTIDLTHEDNQYSIGNlkpdteYEVSLISR 876
Cdd:COG4733   533 PVNVTTSESLSVVAQGTAVTTLTVSWDAPAGAVAyEVEWRRDDGNWVSVPRTSGTSFEVPGIYAGD------YEVRVRAI 606

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  877 -RVDMASNPA--KETFITGLD----APRNLRrVSQTDNSITLEWRN-VKADIDSYRIKYAPisGGDHAEIDVPKSQQATT 948
Cdd:COG4733   607 nALGVSSAWAasSETTVTGKTapppAPTGLT-ATGGLGGITLSWSFpVDADTLRTEIRYST--TGDWASATVAQALYPGN 683

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  949 KTTLTGLRPGTEYGVGVSAVkgDKEGD--PATINAATEIDAPRDLQvsettqdsltlfwktplakfdryrlnysLPTGQS 1026
Cdd:COG4733   684 TYTLAGLKAGQTYYYRARAV--DRSGNvsAWWVSGQASADAAGILD----------------------------AITGQI 733

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1027 IEIQLPK--DATSHVLTDLEPGQEYTVLLTAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDLAYE-Y 1103
Cdd:COG4733   734 LETELGQelDAIIQNATVAEVVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDAsG 813

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1104 FVIQVQEANKVETAHNFTVLGNLRTADIPGLKAATPYRVSIYGVARGYKTPVLSAETFTGKTPSLGEVTVAEVGWDALKL 1183
Cdd:COG4733   814 GVTAGTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADST 893

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 672052774 1184 NW--TAPEGAYTNFFIQvleADMTQTVQNLTVPGG 1216
Cdd:COG4733   894 AAslTAIVIAATTIIDA---IGDGTTREPAGDIGA 925
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1171-1253 2.35e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1171 VTVAEVGWDALKLNWTAPE---GAYTNFFIQVLEADMTQTVQNLTVPGGLRSVDLPGLKAATRYYITVRGVTQDFSTAPL 1247
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                  ....*.
gi 672052774 1248 SVEVLT 1253
Cdd:cd00063    87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 2.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|..
gi 672052774  790 TRGPGLKKVTTT 801
Cdd:cd00063    81 GESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 2.90e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 2.90e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774    713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 672052774    791 RGPG 794
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1531-1609 8.10e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 8.10e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1531 PEVDNLLVSDATPDGFRLSWTA-DEGIFDSFVIRIRDTKKQSEPQEITLPSPDRTR--DITGLREATEYEIELYGISRGR 1607
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsyTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774   1608 RS 1609
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1710-1786 1.08e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.08e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774   1710 DGPSGLLTANITDSEALAMWQ-PAIATVDSYVISYTGERVPEITR----TVSGNTVEFELHDLEPATEYTLSVFAEKGHQ 1784
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEGSEwkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 672052774   1785 KS 1786
Cdd:smart00060   82 EG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 1.22e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 46.52  E-value: 1.22e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1171-1240 4.35e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 4.35e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672052774   1171 VTVAEVGWDALKLNWTAPEGAYTNFFI---QVLEADMTQTVQNLTVPGGLRSVDLPGLKAATRYYITVRGVTQ 1240
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIvgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1353-1425 5.60e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 5.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774 1353 LIFSNITPDSFHVSWTTQAGLFAKI---VINVRDAHSLHESRQITVPGDAQQAHITGLVENTAYDVSVTGTTWAGD 1425
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 8.09e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.21  E-value: 8.09e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   190 CPGNCNLRGQCLDGQCICDQGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1710-1795 8.19e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 8.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1710 DGPSGLLTANITDSEALAMWQPA---IATVDSYVISY--TGERVPEITRTVSGNTVEFELHDLEPATEYTLSVFAEKGHQ 1784
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 672052774 1785 KS-STIATKFTT 1795
Cdd:cd00063    82 ESpPSESVTVTT 93
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 8.41e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.21  E-value: 8.41e-06
                           10        20
                   ....*....|....*....|....*...
gi 672052774   501 CPRDCSQRGRCVDGQCICEDGFTGSDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1078-1162 1.14e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1078 ENLTVTEAGWDGLRLNWTA---DDLAYEYFVIQVQEANKVETAHNFTVLGNLRTADIPGLKAATPYRVSIYGVARGYKTP 1154
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84


                  ....*...
gi 672052774 1155 VLSAETFT 1162
Cdd:cd00063    85 PSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1353-1425 2.00e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 2.00e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774   1353 LIFSNITPDSFHVSWT--TQAGLFAKIV-INVRDAHSLHESRQITVPGDAQQAHITGLVENTAYDVSVTGTTWAGD 1425
Cdd:smart00060    7 LRVTDVTSTSVTLSWEppPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
943-1281 1.20e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.30  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  943 SQQATTKTTLTGLRPGTEYGVGVSAVKGDKEGDPATINAATEIDAPRDLQVSETTQDSLTLFWKTPLAKFDRYRLNYSLP 1022
Cdd:COG3401    11 AGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1023 TGQSIEIQLPKDATSHVLTDLEPGQEYTVL--LTAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDLA 1100
Cdd:COG3401    91 ATGLTTLTGSGSVGGATNTGLTSSDEVPSPavGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1101 YEYFViqvqeANKVETAHNFTVLGNLRTADIPGLKAATPYRVSIYGVARGYKTPVLSAETFTGKT-----PSlgEVTVAE 1175
Cdd:COG3401   171 SPDTS-----ATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTtppsaPT--GLTATA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1176 VGWDALKLNWTAPEGAYTNFFiQVLEADMTQ-TVQNLTVPGGLRSVDlPGLKAATRYYITVRGVTQDFSTAPLS--VEVL 1252
Cdd:COG3401   244 DTPGSVTLSWDPVTESDATGY-RVYRSNSGDgPFTKVATVTTTSYTD-TGLTNGTTYYYRVTAVDAAGNESAPSnvVSVT 321

                         330       340       350
                  ....*....|....*....|....*....|.
gi 672052774 1253 TAKEP--EIGNLNISDVTPESFNLSWTATDG 1281
Cdd:COG3401   322 TDLTPpaAPSGLTATAVGSSSITLSWTASSD 352
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 1.58e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.74  E-value: 1.58e-04
                           10        20
                   ....*....|....*....|....*..
gi 672052774   470 CPNDCHQHGRCVNGMCICDDDYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 4.47e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.20  E-value: 4.47e-04
                           10        20
                   ....*....|....*....|....*...
gi 672052774   594 CPNDCSNQGQCVAGRCICNEGYTGVDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
fn3_2 pfam16893
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ...
 713-783 4.67e-04

Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.


Pssm-ID: 435634  Cd Length: 89  Bit Score: 41.03  E-value: 4.67e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672052774   713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWE--IIFRNMNKedEGEITKSLRRpeTSYRQTGLAPGQEYEISL 783
Cdd:pfam16893    3 PKAPVLKVRNVTQTSVVLEWDPLELGTAKLKslDLYRNGQR--LGVIPNPLTN--TSTKLSGLSVDTEYTFQL 71
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 412-434 5.19e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 5.19e-04
                           10        20
                   ....*....|....*....|....*
gi 672052774   412 CSGHGRCVN--GQCVCDEGYTGEDC 434
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1443-1527 5.72e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1443 ENLTISDTNPYGFTVSWTASEN---AFDSFLVTVVDSGKLlDPQEF-TLSGTQRKLELRGLITGIGYEVLVSGFTQGHQT 1518
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSG-DWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....*....
gi 672052774 1519 KPLRAETIT 1527
Cdd:cd00063    84 PPSESVTVT 92
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 8.73e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 8.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 672052774   380 DCHHHGRC--LNGQCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 9.82e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 9.82e-04
                           10        20
                   ....*....|....*....|....*.
gi 672052774   535 DCHGHGRCVN--GQCICHEGFTGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1078-1147 1.32e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 1.32e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672052774   1078 ENLTVTEAGWDGLRLNWT--ADDLAYEYFV-IQVQEANKVETAHNFTVLGNLRTADIPGLKAATPYRVSIYGV 1147
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEppPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 350-372 1.70e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.70e-03
                           10        20
                   ....*....|....*....|....*
gi 672052774   350 CQGHGQCE--EGQCVCNEGFAGADC 372
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 1.88e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 1.88e-03
                           10        20
                   ....*....|....*....|....*...
gi 672052774   439 CPNDCHNRGHCVQGKCICEQGFKGFDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
987-1287 2.26e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 42.84  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774  987 APRDLQVSETTQDSLTLFW-----KTPLAKFDRYRlnyslpTGQSIEIQlpKDATSHVLTDLEPGQEYTVLLTAeKGrhk 1061
Cdd:COG3979     5 APTGLTASNVTSSSVSLSWdastdNVGVTGYDVYR------GGDQVATV--TGLTAWTVTGLTPGTEYTFTVGA-CD--- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1062 SKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDlaYEYFVIQVQEANKVETAHNFTVLGNLRTADIPGLKAATPYR 1141
Cdd:COG3979    73 AAGNVSAASGTSTAMFGGSSTTLGSAEGVADTSGNLA--ASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSGG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672052774 1142 VSIYGVARGYKTPvlSAETFTGKTPSLGEVTVAEVGWDALKLNWTAPEGAYTNFFIQVLEADMTQTVQNLTVPGGLRSVD 1221
Cdd:COG3979   151 TTTIITTGVEGGG--GSKTAQSLNAITAAGTAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSGT 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672052774 1222 LPGLKAATRYYITVRGVTQDFSTAPLSVEVLTAKEPEIGNLNISDVTPESFNLSWTATDGIFDMFT 1287
Cdd:COG3979   229 TATGGTVGITSAYGAGVSGNAAVNVNAGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLN 294
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 3.39e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|....*....
gi 672052774   252 CPVPCSEEhGMCVDGRCVCKDGFAGEDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 3.66e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 3.66e-03
                           10        20
                   ....*....|....*....|....*...
gi 672052774   284 CFNNCNNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-434 3.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.96e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 672052774  409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054     8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 526-559 4.07e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 672052774  526 DCAElscPGDCHGHGRCVNG----QCICHEGFTGKDCK 559
Cdd:cd00054     4 ECAS---GNPCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 532-558 4.55e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 4.55e-03
                           10        20
                   ....*....|....*....|....*..
gi 672052774   532 CPGDCHGHGRCVNGQCICHEGFTGKDC 558
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 504-527 4.64e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.56  E-value: 4.64e-03
                           10        20
                   ....*....|....*....|....*.
gi 672052774   504 DCSQRGRCVD--GQCICEDGFTGSDC 527
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 4.82e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 4.82e-03
                           10        20
                   ....*....|....*....|....*...
gi 672052774   346 CPNNCQGHGQCEEGQCVCNEGFAGADCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1260-1324 5.62e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 5.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672052774 1260 GNLNISDVTPESFNLSWTA---TDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIV 1324
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEF 72
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 597-620 6.80e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.79  E-value: 6.80e-03
                           10        20
                   ....*....|....*....|....*.
gi 672052774   597 DCSNQGQCVA--GRCICNEGYTGVDC 620
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 8.71e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 35.74  E-value: 8.71e-03
                           10        20
                   ....*....|....*....|....*..
gi 672052774   563 CPSDCHGQGRCEDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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