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Conserved domains on  [gi|755555059|ref|XP_011244453|]
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immunoglobulin superfamily member 5 isoform X1 [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12209963)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-126 3.73e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 3.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059    31 PQNVTVLKDSEAHFNCTVTHGWKLLMWTLNQmvvlsltTQGPIITNNRFTYasynSTDSFISELIIHDVQPSDSGSVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQ-------GGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 755555059   111 LQNSHGFGSAFLSVQV 126
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 129-204 1.72e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.55  E-value: 1.72e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755555059  129 TLNIPSNNLIVTEGEPCNVTCYAVGWTSlPDISWELEVPVSHSSYNSFLEPGNFMRVLSVLDLTPLGNGTLTCVAE 204
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPP-PTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-126 3.73e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 3.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059    31 PQNVTVLKDSEAHFNCTVTHGWKLLMWTLNQmvvlsltTQGPIITNNRFTYasynSTDSFISELIIHDVQPSDSGSVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQ-------GGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 755555059   111 LQNSHGFGSAFLSVQV 126
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
 26-126 1.42e-05

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 43.56  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059  26 QIIEGPQNVTVLKDSEAHFNCTVThGWK--LLMWTLNQMVVLSLTTQGPIITNNRftyasYNstdsfISELIIHDVQPSD 103
Cdd:cd20951    2 EFIIRLQSHTVWEKSDAKLRVEVQ-GKPdpEVKWYKNGVPIDPSSIPGKYKIESE-----YG-----VHVLHIRRVTVED 70

                         90       100
                 ....*....|....*....|...
gi 755555059 104 SGSVQCSLQNSHGFGSAFLSVQV 126
Cdd:cd20951   71 SAVYSAVAKNIHGEASSSASVVV 93
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 129-204 1.72e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.55  E-value: 1.72e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755555059  129 TLNIPSNNLIVTEGEPCNVTCYAVGWTSlPDISWELEVPVSHSSYNSFLEPGNFMRVLSVLDLTPLGNGTLTCVAE 204
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPP-PTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 26-113 2.18e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059   26 QIIEGPQNVTVLKDSEAHFNCTVTHGWK-LLMWTLNQMVVLSLTTqgpiitnnrftyaSYNSTDSFISELIIHDVQPSDS 104
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPpTITWYKNGEPISSGST-------------RSRSLSGSNSTLTISNVTRSDA 69


                  ....*....
gi 755555059  105 GSVQCSLQN 113
Cdd:pfam13927  70 GTYTCVASN 78
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-126 3.73e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 3.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059    31 PQNVTVLKDSEAHFNCTVTHGWKLLMWTLNQmvvlsltTQGPIITNNRFTYasynSTDSFISELIIHDVQPSDSGSVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQ-------GGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 755555059   111 LQNSHGFGSAFLSVQV 126
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
 26-126 1.42e-05

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 43.56  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059  26 QIIEGPQNVTVLKDSEAHFNCTVThGWK--LLMWTLNQMVVLSLTTQGPIITNNRftyasYNstdsfISELIIHDVQPSD 103
Cdd:cd20951    2 EFIIRLQSHTVWEKSDAKLRVEVQ-GKPdpEVKWYKNGVPIDPSSIPGKYKIESE-----YG-----VHVLHIRRVTVED 70

                         90       100
                 ....*....|....*....|...
gi 755555059 104 SGSVQCSLQNSHGFGSAFLSVQV 126
Cdd:cd20951   71 SAVYSAVAKNIHGEASSSASVVV 93
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 129-204 1.72e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.55  E-value: 1.72e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755555059  129 TLNIPSNNLIVTEGEPCNVTCYAVGWTSlPDISWELEVPVSHSSYNSFLEPGNFMRVLSVLDLTPLGNGTLTCVAE 204
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPP-PTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 26-113 2.18e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059   26 QIIEGPQNVTVLKDSEAHFNCTVTHGWK-LLMWTLNQMVVLSLTTqgpiitnnrftyaSYNSTDSFISELIIHDVQPSDS 104
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPpTITWYKNGEPISSGST-------------RSRSLSGSNSTLTISNVTRSDA 69


                  ....*....
gi 755555059  105 GSVQCSLQN 113
Cdd:pfam13927  70 GTYTCVASN 78
I-set pfam07679
Immunoglobulin I-set domain;
26-124 2.43e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.93  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059   26 QIIEGPQNVTVLKDSEAHFNCTVThGWKL--LMWTLNQMvvlslttqgPIITNNRFTYasynSTDSFISELIIHDVQPSD 103
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVT-GTPDpeVSWFKDGQ---------PLRSSDRFKV----TYEGGTYTLTISNVQPDD 67

                          90       100
                  ....*....|....*....|...
gi 755555059  104 SGSVQCSLQNSHG--FGSAFLSV 124
Cdd:pfam07679  68 SGKYTCVATNSAGeaEASAELTV 90
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 31-124 5.73e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 38.72  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755555059   31 PQNVTVLKDSEAHFNCTVTHGwkllmwTLNQMVVLSLTTQGPIITnnrfTYASYNSTDSFISELIIHDVQPSDSGSVQCS 110
Cdd:pfam00047   3 PPTVTVLEGDSATLTCSASTG------SPGPDVTWSKEGGTLIES----LKVKHDNGRTTQSSLLISNVTKEDAGTYTCV 72

                          90
                  ....*....|....
gi 755555059  111 LQNSHGFGSAFLSV 124
Cdd:pfam00047  73 VNNPGGSATLSTSL 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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