NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755537697|ref|XP_011247109|]
View 

peroxisomal sarcosine oxidase isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 8-374 0e+00

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


:

Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 672.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697    8 WDAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPHSRGSSHGQSRIIRKAYPEDFYTMMMKECYQTWAQLEREAGTQLH 87
Cdd:TIGR01377   1 FDVIVVGAGIMGCFAAYHLAKHGKKTLLLEQFDLPHSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWAQLEKEAGTKLH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   88 RQTELLLLGTKENPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHIICQLGG 167
Cdd:TIGR01377  81 RQTGLLLLGPKENQFLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELAEAHGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  168 TVCDGEKVVEIRP-GLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGIELPLQTLRINVCYWREKVPGSYGVSQAFPCI 246
Cdd:TIGR01377 161 TVRDGTKVVEIEPtELLVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEPGSYGVSQAFPCF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  247 LGLDLAPhHIYGLPASEYPGLMKICYHHGDNVDPEERDCPKTfSDIQDVQILCHFVRDHLPGLRAEPDIMERCMYT---- 322
Cdd:TIGR01377 241 LVLGLNP-HIYGLPSFEYPGLMKVYYHHGQQIDPDERDCPFG-ADIEDVQILRKFVRDHLPGLNGEPKKGEVCMYTntpd 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755537697  323 ----------YDNIVIGAGFSGHGFKLAPVVGKILYELSMKLPPSYDLAPFRMSRFSTLSKA 374
Cdd:TIGR01377 319 ehfvidlhpkYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRFALKKKA 380
 
Name Accession Description Interval E-value
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 8-374 0e+00

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 672.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697    8 WDAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPHSRGSSHGQSRIIRKAYPEDFYTMMMKECYQTWAQLEREAGTQLH 87
Cdd:TIGR01377   1 FDVIVVGAGIMGCFAAYHLAKHGKKTLLLEQFDLPHSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWAQLEKEAGTKLH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   88 RQTELLLLGTKENPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHIICQLGG 167
Cdd:TIGR01377  81 RQTGLLLLGPKENQFLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELAEAHGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  168 TVCDGEKVVEIRP-GLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGIELPLQTLRINVCYWREKVPGSYGVSQAFPCI 246
Cdd:TIGR01377 161 TVRDGTKVVEIEPtELLVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEPGSYGVSQAFPCF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  247 LGLDLAPhHIYGLPASEYPGLMKICYHHGDNVDPEERDCPKTfSDIQDVQILCHFVRDHLPGLRAEPDIMERCMYT---- 322
Cdd:TIGR01377 241 LVLGLNP-HIYGLPSFEYPGLMKVYYHHGQQIDPDERDCPFG-ADIEDVQILRKFVRDHLPGLNGEPKKGEVCMYTntpd 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755537697  323 ----------YDNIVIGAGFSGHGFKLAPVVGKILYELSMKLPPSYDLAPFRMSRFSTLSKA 374
Cdd:TIGR01377 319 ehfvidlhpkYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRFALKKKA 380
solA PRK11259
N-methyl-L-tryptophan oxidase;
9-369 1.10e-83

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 259.38  E-value: 1.10e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPHSRGSSHGQSRIIRKAYPED-FYTMMMKECYQTWAQLEREAGTQLH 87
Cdd:PRK11259   5 DVIVIGLGSMGSAAGYYLARRGLRVLGLDRFMPPHQQGSSHGDTRIIRHAYGEGpAYVPLVLRAQELWRELERESGEPLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  88 RQTELLLLGTKENPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHIICQLGG 167
Cdd:PRK11259  85 VRTGVLNLGPADSDFLANSIRSARQHGLPHEVLDAAEIRRRFPQFRLPDGYIALFEPDGGFLRPELAIKAHLRLAREAGA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 168 TVCDGEKVVEIRP-GLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGieLPLQTLRiNVCYWREKVPGsYGVSQAFPCI 246
Cdd:PRK11259 165 ELLFNEPVTAIEAdGDGVTVTTADGTYEAKKLVVSAGAWVKDLLPPLE--LPLTPVR-QVLAWFQADGR-YSEPNRFPAF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 247 LGLDLAPHHIYGLPASEYPGLmKICYHHG--DNVDPEERDcpKTFSDIQDVQILCHFVRDHLPG----LRAEPdimerCM 320
Cdd:PRK11259 241 IWEVPDGDQYYGFPAENGPGL-KIGKHNGgqEITSPDERD--RFVTVAEDGAELRPFLRNYLPGvgpcLRGAA-----CT 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755537697 321 YT--------------YDNIVIGAGFSGHGFKLAPVVGKILYELSMKLPPSYDLAPFRMSRFS 369
Cdd:PRK11259 313 YTntpdehfiidtlpgHPNVLVASGCSGHGFKFASVLGEILADLAQDGTSDFDLSPFSLSRFA 375
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
9-367 1.53e-55

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 186.26  E-value: 1.53e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPhsRGSSHGQSRIIRKAYPED---FYTMMMKECYQTWAQLEREAGTQ 85
Cdd:COG0665    4 DVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPG--SGASGRNAGQLRPGLAALadrALVRLAREALDLWRELAAELGID 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  86 L-HRQTELLLLGTKENP--GLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHII 162
Cdd:COG0665   82 CdFRRTGVLYLARTEAElaALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARAA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 163 CQLGGTVCDGEKVVEIRP--GLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGIELPLQTLRinvcywrekvpgsyGVS 240
Cdd:COG0665  162 RAAGVRIREGTPVTGLERegGRVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVR--------------GYV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 241 QAFPCILGLDLAP----HHIYGLPASEypGLMKI-CYHHGDNVDPEERDcpktfsdiQDVQILCHFVRDHLPGLRAEPDI 315
Cdd:COG0665  228 LVTEPLPDLPLRPvlddTGVYLRPTAD--GRLLVgGTAEPAGFDRAPTP--------ERLEALLRRLRRLFPALADAEIV 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755537697 316 MER-CMYTY--------------DNIVIGAGFSGHGFKLAPVVGKILYELSMKLPPSYDLAPFRMSR 367
Cdd:COG0665  298 RAWaGLRPMtpdglpiigrlpgaPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 9-350 1.91e-45

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 159.10  E-value: 1.91e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697    9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPhSRGSSHGQSRIIR---KAYPEDFYTMMMKECYQTWAQLEREAGTQ 85
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDP-GSGASGRNAGLIHpglRYLEPSELARLALEALDLWEELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   86 L-HRQTELLLLGTKE-NPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGevGLLDKTGGVLYADKALRALQHIIC 163
Cdd:pfam01266  80 CgFRRCGVLVLARDEeEEALEKLLAALRRLGVPAELLDAEELRELEPLLPGLRG--GLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  164 QLGGTVCDGEKVVEIRPGLPVTVKTTLKSYQAnsLVITAGPWTnRLLHPLGIELPLQTLR---INVCYWREKVPGSYgvs 240
Cdd:pfam01266 158 ALGVRIIEGTEVTGIEEEGGVWGVVTTGEADA--VVNAAGAWA-DLLALPGLRLPVRPVRgqvLVLEPLPEALLILP--- 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  241 qafpcILGLDLAPHHIYGLPASEypGLMKICYHHgDNVDPEERDcpktfSDIQDVQILCHFVRDHLP----------GLR 310
Cdd:pfam01266 232 -----VPITVDPGRGVYLRPRAD--GRLLLGGTD-EEDGFDDPT-----PDPEEIEELLEAARRLFPaladierawaGLR 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 755537697  311 AEPD---IMERcmYTYDNIVIGAGFSGHGFKLAPVVGKILYEL 350
Cdd:pfam01266 299 PLPDglpIIGR--PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
 
Name Accession Description Interval E-value
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 8-374 0e+00

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 672.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697    8 WDAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPHSRGSSHGQSRIIRKAYPEDFYTMMMKECYQTWAQLEREAGTQLH 87
Cdd:TIGR01377   1 FDVIVVGAGIMGCFAAYHLAKHGKKTLLLEQFDLPHSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWAQLEKEAGTKLH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   88 RQTELLLLGTKENPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHIICQLGG 167
Cdd:TIGR01377  81 RQTGLLLLGPKENQFLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELAEAHGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  168 TVCDGEKVVEIRP-GLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGIELPLQTLRINVCYWREKVPGSYGVSQAFPCI 246
Cdd:TIGR01377 161 TVRDGTKVVEIEPtELLVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEPGSYGVSQAFPCF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  247 LGLDLAPhHIYGLPASEYPGLMKICYHHGDNVDPEERDCPKTfSDIQDVQILCHFVRDHLPGLRAEPDIMERCMYT---- 322
Cdd:TIGR01377 241 LVLGLNP-HIYGLPSFEYPGLMKVYYHHGQQIDPDERDCPFG-ADIEDVQILRKFVRDHLPGLNGEPKKGEVCMYTntpd 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755537697  323 ----------YDNIVIGAGFSGHGFKLAPVVGKILYELSMKLPPSYDLAPFRMSRFSTLSKA 374
Cdd:TIGR01377 319 ehfvidlhpkYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRFALKKKA 380
solA PRK11259
N-methyl-L-tryptophan oxidase;
9-369 1.10e-83

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 259.38  E-value: 1.10e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPHSRGSSHGQSRIIRKAYPED-FYTMMMKECYQTWAQLEREAGTQLH 87
Cdd:PRK11259   5 DVIVIGLGSMGSAAGYYLARRGLRVLGLDRFMPPHQQGSSHGDTRIIRHAYGEGpAYVPLVLRAQELWRELERESGEPLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  88 RQTELLLLGTKENPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHIICQLGG 167
Cdd:PRK11259  85 VRTGVLNLGPADSDFLANSIRSARQHGLPHEVLDAAEIRRRFPQFRLPDGYIALFEPDGGFLRPELAIKAHLRLAREAGA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 168 TVCDGEKVVEIRP-GLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGieLPLQTLRiNVCYWREKVPGsYGVSQAFPCI 246
Cdd:PRK11259 165 ELLFNEPVTAIEAdGDGVTVTTADGTYEAKKLVVSAGAWVKDLLPPLE--LPLTPVR-QVLAWFQADGR-YSEPNRFPAF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 247 LGLDLAPHHIYGLPASEYPGLmKICYHHG--DNVDPEERDcpKTFSDIQDVQILCHFVRDHLPG----LRAEPdimerCM 320
Cdd:PRK11259 241 IWEVPDGDQYYGFPAENGPGL-KIGKHNGgqEITSPDERD--RFVTVAEDGAELRPFLRNYLPGvgpcLRGAA-----CT 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755537697 321 YT--------------YDNIVIGAGFSGHGFKLAPVVGKILYELSMKLPPSYDLAPFRMSRFS 369
Cdd:PRK11259 313 YTntpdehfiidtlpgHPNVLVASGCSGHGFKFASVLGEILADLAQDGTSDFDLSPFSLSRFA 375
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
9-367 1.53e-55

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 186.26  E-value: 1.53e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPhsRGSSHGQSRIIRKAYPED---FYTMMMKECYQTWAQLEREAGTQ 85
Cdd:COG0665    4 DVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPG--SGASGRNAGQLRPGLAALadrALVRLAREALDLWRELAAELGID 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  86 L-HRQTELLLLGTKENP--GLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHII 162
Cdd:COG0665   82 CdFRRTGVLYLARTEAElaALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARAA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 163 CQLGGTVCDGEKVVEIRP--GLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGIELPLQTLRinvcywrekvpgsyGVS 240
Cdd:COG0665  162 RAAGVRIREGTPVTGLERegGRVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVR--------------GYV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 241 QAFPCILGLDLAP----HHIYGLPASEypGLMKI-CYHHGDNVDPEERDcpktfsdiQDVQILCHFVRDHLPGLRAEPDI 315
Cdd:COG0665  228 LVTEPLPDLPLRPvlddTGVYLRPTAD--GRLLVgGTAEPAGFDRAPTP--------ERLEALLRRLRRLFPALADAEIV 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755537697 316 MER-CMYTY--------------DNIVIGAGFSGHGFKLAPVVGKILYELSMKLPPSYDLAPFRMSR 367
Cdd:COG0665  298 RAWaGLRPMtpdglpiigrlpgaPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 9-350 1.91e-45

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 159.10  E-value: 1.91e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697    9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPhSRGSSHGQSRIIR---KAYPEDFYTMMMKECYQTWAQLEREAGTQ 85
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDP-GSGASGRNAGLIHpglRYLEPSELARLALEALDLWEELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   86 L-HRQTELLLLGTKE-NPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGevGLLDKTGGVLYADKALRALQHIIC 163
Cdd:pfam01266  80 CgFRRCGVLVLARDEeEEALEKLLAALRRLGVPAELLDAEELRELEPLLPGLRG--GLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  164 QLGGTVCDGEKVVEIRPGLPVTVKTTLKSYQAnsLVITAGPWTnRLLHPLGIELPLQTLR---INVCYWREKVPGSYgvs 240
Cdd:pfam01266 158 ALGVRIIEGTEVTGIEEEGGVWGVVTTGEADA--VVNAAGAWA-DLLALPGLRLPVRPVRgqvLVLEPLPEALLILP--- 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  241 qafpcILGLDLAPHHIYGLPASEypGLMKICYHHgDNVDPEERDcpktfSDIQDVQILCHFVRDHLP----------GLR 310
Cdd:pfam01266 232 -----VPITVDPGRGVYLRPRAD--GRLLLGGTD-EEDGFDDPT-----PDPEEIEELLEAARRLFPaladierawaGLR 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 755537697  311 AEPD---IMERcmYTYDNIVIGAGFSGHGFKLAPVVGKILYEL 350
Cdd:pfam01266 299 PLPDglpIIGR--PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
9-267 4.10e-16

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 79.03  E-value: 4.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAK-HSKSVLLLEQffLPH-SRGSSHGQSRIIRKAYPEDFYTMMMKEC---YQTWAQLEREAG 83
Cdd:COG0579    6 DVVIIGAGIVGLALARELSRyEDLKVLVLEK--EDDvAQESSGNNSGVIHAGLYYTPGSLKARLCvegNELFYELCRELG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  84 TQlHRQTELLLLGTKEN--PGLKTIQATLSRQGIDH-EYLSSVDLKQRFPNIRfTRGEVGLLDKTGGVLYADKALRALQH 160
Cdd:COG0579   84 IP-FKRCGKLVVATGEEevAFLEKLYERGKANGVPGlEILDREELRELEPLLS-DEGVAALYSPSTGIVDPGALTRALAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 161 IICQLGGTVCDGEKVVEIRP---GlpVTVKTTLKSYQANSLVITAGPWTNRLLHPLGIELPLQTlrinvcywrekVP--G 235
Cdd:COG0579  162 NAEANGVELLLNTEVTGIERegdG--WEVTTNGGTIRARFVINAAGLYADRLAQMAGIGKDFGI-----------FPvkG 228

                        250       260       270
                 ....*....|....*....|....*....|....
gi 755537697 236 SYgvsqafpCIL--GLDLAPHHIYGLPASEYPGL 267
Cdd:COG0579  229 EY-------LVLdkPAELVNAKVYPVPDPGAPFL 255
thiamin_ThiO TIGR02352
glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine ...
 24-350 3.48e-08

glycine oxidase ThiO; This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]


Pssm-ID: 274092 [Multi-domain]  Cd Length: 337  Bit Score: 54.68  E-value: 3.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   24 YHLAKHSKSVLLLEQffLPHSRGSSHGQSRII-----RKAYPEDFYTMMMKEC--YQTWAQLEREAgTQL---HRQTELL 93
Cdd:TIGR02352   1 WELAKRGHSVTLFDR--DPMGGGASWAAAGMLaphaeCEYAEDPLFDLALESLrlYPEWLEALKEL-TGLdtgYHQCGTL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   94 LLGTKENPG--LKTIQATLSRQGIDHEYLSSVDLKQRFPNI--RFTRG----EVGLLDktggvlyADKALRALQHIICQL 165
Cdd:TIGR02352  78 VVAFDEDDVehLRQLADLQSATGMEVEWLSGRALRRLEPYLsgGIRGAvfypDDAHVD-------PRALLKALEKALEKL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  166 GGTVCDGEKV--VEIRPGLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGIELPLQTLRINVC-YWREKVPGSYGVSQa 242
Cdd:TIGR02352 151 GVEIIEHTEVqhIEIRGEKVTAIVTPSGDVQADQVVLAAGAWAGELLPLPLRPVRGQPLRLEAPaVPLLNRPLRAVVYG- 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  243 fpcilgldlapHHIYGLP---------ASEYPglmkicyhHGDNVDPEERDCPKTFSD-------IQDVQILchfvrDHL 306
Cdd:TIGR02352 230 -----------RRVYIVPrrdgrlvvgATMEE--------SGFDTTPTLGGIKELLRDaytilpaLKEARLL-----ETW 285

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 755537697  307 PGLR-AEPDIMERCMYTYD--NIVIGAGFSGHGFKLAPVVGKILYEL 350
Cdd:TIGR02352 286 AGLRpGTPDNLPYIGEHPEdrRLLIATGHYRNGILLAPATAEVIADL 332
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 8-38 2.85e-06

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 48.47  E-value: 2.85e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755537697    8 WDAIVIGAGIQGCFTAYHLAKHSKSVLLLEQ 38
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKGLRVLLLEK 31
HpnW_proposed TIGR03364
FAD dependent oxidoreductase TIGR03364; This clade of FAD dependent oxidoreductases (members ...
 9-203 1.02e-05

FAD dependent oxidoreductase TIGR03364; This clade of FAD dependent oxidoreductases (members of the pfam01266 family) is syntenically associated with a family of proposed phosphonatase-like enzymes (TIGR03351) and is also found (less frequently) in association with phosphonate transporter components. A likely role for this enzyme involves the oxidative deamination of an aminophosphonate differring slightly from 2-aminoethylphosphonate, possibly 1-hydroxy-2-aminoethylphosphonate (see the comments for TIGR03351). Many members of the larger FAD dependent oxidoreductase family act as amino acid oxidative deaminases.


Pssm-ID: 132407 [Multi-domain]  Cd Length: 365  Bit Score: 46.91  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697    9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQffLPHSRGSS---HGQSRIIRKAyPEDFYTMMMkECYQTWAQLEREAGTQ 85
Cdd:TIGR03364   2 DLIIVGAGILGLAHAYAAARRGLSVTVIER--SSRAQGASvrnFGQVWPTGQA-PGPAWDRAR-RSREIWLELAAKAGIW 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   86 LhRQTELLLLGTKEnPGLKTIQ---ATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHII 162
Cdd:TIGR03364  78 V-RENGSLHLARTE-EELAVLEefaATREPAEYRVELLTPAEVAAKFPALRLDGLRGGLHSPDELRVEPREAIPALAAYL 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 755537697  163 CQLGG-TVCDGEKVVEIRPGlpvTVKTTLKSYQANSLVITAG 203
Cdd:TIGR03364 156 AEQHGvEFHWNTAVTSVETG---TVRTSRGDVHADQVFVCPG 194
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
9-220 1.07e-05

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 47.12  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAK--HSKSVLLLEqfflphsrgsshgqsriirkaypedfytmmmKE----CYQTW------- 75
Cdd:PRK11728   4 DFVIIGGGIVGLSTAMQLQEryPGARIAVLE-------------------------------KEsgpaRHQTGhnsgvih 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697  76 -----------AQLEREAGTQL----------HRQTELLLLGT--KENPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNI 132
Cdd:PRK11728  53 agvyytpgslkARFCRRGNEATkafcdqhgipYEECGKLLVATseLELERMEALYERARANGIEVERLDAEELREREPNI 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697 133 rftRGEVGLL-DKTGGVLYADKAlRALQHIICQLGGTVCDGEKVVEIRP-GLPVTVKTTLKSYQANSLVITAGPWTNRLL 210
Cdd:PRK11728 133 ---RGLGAIFvPSTGIVDYRAVA-EAMAELIQARGGEIRLGAEVTALDEhANGVVVRTTQGEYEARTLINCAGLMSDRLA 208

                        250
                 ....*....|
gi 755537697 211 HPLGIELPLQ 220
Cdd:PRK11728 209 KMAGLEPDFR 218
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 9-152 2.94e-05

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 45.99  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPHSRGSSHGQ--------------SRIIRKAYpedFYTMmmkecyQT 74
Cdd:PRK01747 262 DAAIIGGGIAGAALALALARRGWQVTLYEADEAPAQGASGNRQgalypllskddnalSRFFRAAF---LFAR------RF 332

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755537697  75 WAQLEREAGTQLHRQTELLLLGtkENPGLKTIQATLSRQGIDHEYLSSVDLKQrfpnirfTRGEVGLLDKTGGVLYAD 152
Cdd:PRK01747 333 YDALPAAGVAFDHDWCGVLQLA--WDEKSAEKIAKMLALGLPAELARALDAEE-------AEELAGLPVPCGGIFYPQ 401
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
12-38 8.46e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 40.21  E-value: 8.46e-05
                          10        20
                  ....*....|....*....|....*..
gi 755537697   12 VIGAGIQGCFTAYHLAKHSKSVLLLEQ 38
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEK 27
COG3573 COG3573
Predicted oxidoreductase [General function prediction only];
9-38 5.08e-04

Predicted oxidoreductase [General function prediction only];


Pssm-ID: 442794 [Multi-domain]  Cd Length: 551  Bit Score: 42.09  E-value: 5.08e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQ 38
Cdd:COG3573    7 DVIVVGAGLAGLVAAAELADAGRRVLLLDQ 36
PRK12834 PRK12834
putative FAD-binding dehydrogenase; Reviewed
 9-38 1.59e-03

putative FAD-binding dehydrogenase; Reviewed


Pssm-ID: 183782 [Multi-domain]  Cd Length: 549  Bit Score: 40.27  E-value: 1.59e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQ 38
Cdd:PRK12834   6 DVIVVGAGLAGLVAAAELADAGKRVLLLDQ 35
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 9-36 1.91e-03

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 40.09  E-value: 1.91e-03
                         10        20
                 ....*....|....*....|....*...
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHsKSVLLL 36
Cdd:COG0029    6 DVLVIGSGIAGLSAALKLAER-GRVTLL 32
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 8-38 1.93e-03

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 40.22  E-value: 1.93e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755537697   8 WDAIVIGAGIQGCFTAYHLAKHSKSVLLLEQ 38
Cdd:COG1233    4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEK 34
PRK10015 PRK10015
oxidoreductase; Provisional
 6-50 3.82e-03

oxidoreductase; Provisional


Pssm-ID: 182194 [Multi-domain]  Cd Length: 429  Bit Score: 39.19  E-value: 3.82e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 755537697   6 DFWDAIVIGAGIQGCFTAYHLAKHSKSVLLLEqfflphsRGSSHG 50
Cdd:PRK10015   4 DKFDAIVVGAGVAGSVAALVMARAGLDVLVIE-------RGDSAG 41
PTZ00367 PTZ00367
squalene epoxidase; Provisional
 8-38 4.71e-03

squalene epoxidase; Provisional


Pssm-ID: 240384 [Multi-domain]  Cd Length: 567  Bit Score: 39.06  E-value: 4.71e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755537697   8 WDAIVIGAGIQGCFTAYHLAKHSKSVLLLEQ 38
Cdd:PTZ00367  34 YDVIIVGGSIAGPVLAKALSKQGRKVLMLER 64
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 8-37 5.65e-03

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 38.66  E-value: 5.65e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755537697   8 WDAIVIGAGIQGCFTAYHLAKH-SKSVLLLE 37
Cdd:COG2303    5 YDYVIVGAGSAGCVLANRLSEDaGLRVLLLE 35
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 9-38 6.16e-03

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 38.27  E-value: 6.16e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 755537697   9 DAIVIGAGIQGCFTAYHLAKHSKSVLLLEQ 38
Cdd:COG1232    3 RVAVIGGGIAGLTAAYRLAKAGHEVTVLEA 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH