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Conserved domains on  [gi|767998870|ref|XP_011524343|]
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dymeclin isoform X6 [Homo sapiens]

Protein Classification

dymeclin( domain architecture ID 10560863)

dymeclin is necessary for correct organization of Golgi apparatus

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-557 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


:

Pssm-ID: 462873  Cd Length: 645  Bit Score: 559.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870    1 MGSNSSRIGdlPKNEYLKKLSGTESISENDPFWNQLLSFSFPAPTSSSELKLLEEATISVCRSLVENNPRTGNLGALIKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870   81 FLSRTKELK--LSAEC-QNHIFIWQTHNALFIICCLLKVFICQMSEEELQLHFTYEEKSPGNYSSDSEDLLEELLCCLM- 156
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGDEDEEGSNRDLPLAESLLl 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  157 ---QLITDIPLLDITYEISVEAISTMVVFLSCQLFHKEVLRQSISHKYLMRGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 alvDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  231 PGAHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGvgSKAAASPELSSPLANQSLL-------LLLVLANLTDASDAPNP 303
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG--SSESESEGTPEPLADQSLQlllvlldHGPTEDPVKSPSGGDNP 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  304 YRQAIMSFKNTQDsspfpssiphaFQINFNSLYTALCEQQTSDQA-TLLLYTLLHQNSNIRTYMLARTDMENLVLPILEI 382
Cdd:pfam09742 317 YRNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPILEL 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  383 LYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTN 462
Cdd:pfam09742 386 LYNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLHTN 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  463 CLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGSLSSNDVP------------------------- 517
Cdd:pfam09742 466 CLAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLGSDDLAqdlsvneevlrllleilnsilqyql 545
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767998870  518 ----------------------LPDY---------VISFFSSRLLQAGAE---LSVERVLEIIKQGVVALPKDR 557
Cdd:pfam09742 546 dgnpnlvyallrkrevfhqfanHPSFqdplqnidrVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLPK 619
 
Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-557 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


Pssm-ID: 462873  Cd Length: 645  Bit Score: 559.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870    1 MGSNSSRIGdlPKNEYLKKLSGTESISENDPFWNQLLSFSFPAPTSSSELKLLEEATISVCRSLVENNPRTGNLGALIKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870   81 FLSRTKELK--LSAEC-QNHIFIWQTHNALFIICCLLKVFICQMSEEELQLHFTYEEKSPGNYSSDSEDLLEELLCCLM- 156
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGDEDEEGSNRDLPLAESLLl 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  157 ---QLITDIPLLDITYEISVEAISTMVVFLSCQLFHKEVLRQSISHKYLMRGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 alvDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  231 PGAHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGvgSKAAASPELSSPLANQSLL-------LLLVLANLTDASDAPNP 303
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG--SSESESEGTPEPLADQSLQlllvlldHGPTEDPVKSPSGGDNP 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  304 YRQAIMSFKNTQDsspfpssiphaFQINFNSLYTALCEQQTSDQA-TLLLYTLLHQNSNIRTYMLARTDMENLVLPILEI 382
Cdd:pfam09742 317 YRNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPILEL 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  383 LYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTN 462
Cdd:pfam09742 386 LYNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLHTN 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  463 CLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGSLSSNDVP------------------------- 517
Cdd:pfam09742 466 CLAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLGSDDLAqdlsvneevlrllleilnsilqyql 545
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767998870  518 ----------------------LPDY---------VISFFSSRLLQAGAE---LSVERVLEIIKQGVVALPKDR 557
Cdd:pfam09742 546 dgnpnlvyallrkrevfhqfanHPSFqdplqnidrVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLPK 619
 
Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-557 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


Pssm-ID: 462873  Cd Length: 645  Bit Score: 559.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870    1 MGSNSSRIGdlPKNEYLKKLSGTESISENDPFWNQLLSFSFPAPTSSSELKLLEEATISVCRSLVENNPRTGNLGALIKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870   81 FLSRTKELK--LSAEC-QNHIFIWQTHNALFIICCLLKVFICQMSEEELQLHFTYEEKSPGNYSSDSEDLLEELLCCLM- 156
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGDEDEEGSNRDLPLAESLLl 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  157 ---QLITDIPLLDITYEISVEAISTMVVFLSCQLFHKEVLRQSISHKYLMRGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 alvDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  231 PGAHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGvgSKAAASPELSSPLANQSLL-------LLLVLANLTDASDAPNP 303
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG--SSESESEGTPEPLADQSLQlllvlldHGPTEDPVKSPSGGDNP 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  304 YRQAIMSFKNTQDsspfpssiphaFQINFNSLYTALCEQQTSDQA-TLLLYTLLHQNSNIRTYMLARTDMENLVLPILEI 382
Cdd:pfam09742 317 YRNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPILEL 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  383 LYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTN 462
Cdd:pfam09742 386 LYNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLHTN 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998870  463 CLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGSLSSNDVP------------------------- 517
Cdd:pfam09742 466 CLAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLGSDDLAqdlsvneevlrllleilnsilqyql 545
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767998870  518 ----------------------LPDY---------VISFFSSRLLQAGAE---LSVERVLEIIKQGVVALPKDR 557
Cdd:pfam09742 546 dgnpnlvyallrkrevfhqfanHPSFqdplqnidrVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLPK 619
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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