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Conserved domains on  [gi|768003900|ref|XP_011526565|]
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zinc finger protein 85 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.08e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.00  E-value: 1.08e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768003900     4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLGITVSKPDLITCLEQGKEAWS 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
273-634 1.52e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 273 KPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKC--EECGKTFNRFSTLTTHKIIHTGEKPYKC-KECGKAFNRSSTLTTH 349
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 350 RKIHTGEKPYKCEECGKAFKQSSNLT--THKIIHTGEKPYK-CKKCGKAFNQSAHL-------------------TTHEV 407
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 408 IHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLT 487
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 488 EHKKIHTGE-------KPYECEKCGKAFNQSSNLTRHKKS--HTEE--KPYKCEE--CGKGFKWPSTLTIHKIIHTGEKP 554
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 555 YKC--EECGKAFNQSS-----KLTKHKKIHTGEKPYTCE--ECGKAFNQSSNLTKHKRIHTGEKP--YKCEECDKAFKWS 623
Cdd:COG5048  352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|.
gi 768003900 624 SVLTKHKIIHT 634
Cdd:COG5048  432 YNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.08e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.00  E-value: 1.08e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768003900     4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLGITVSKPDLITCLEQGKEAWS 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.01e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.22  E-value: 2.01e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768003900    3 PLTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 8.01e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.90  E-value: 8.01e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 768003900   4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
273-634 1.52e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 273 KPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKC--EECGKTFNRFSTLTTHKIIHTGEKPYKC-KECGKAFNRSSTLTTH 349
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 350 RKIHTGEKPYKCEECGKAFKQSSNLT--THKIIHTGEKPYK-CKKCGKAFNQSAHL-------------------TTHEV 407
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 408 IHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLT 487
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 488 EHKKIHTGE-------KPYECEKCGKAFNQSSNLTRHKKS--HTEE--KPYKCEE--CGKGFKWPSTLTIHKIIHTGEKP 554
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 555 YKC--EECGKAFNQSS-----KLTKHKKIHTGEKPYTCE--ECGKAFNQSSNLTKHKRIHTGEKP--YKCEECDKAFKWS 623
Cdd:COG5048  352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|.
gi 768003900 624 SVLTKHKIIHT 634
Cdd:COG5048  432 YNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
597-621 1.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.29e-04
                          10        20
                  ....*....|....*....|....*
gi 768003900  597 NLTKHKRIHTGEKPYKCEECDKAFK 621
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.08e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.00  E-value: 1.08e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768003900     4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLGITVSKPDLITCLEQGKEAWS 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.01e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.22  E-value: 2.01e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768003900    3 PLTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 8.01e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.90  E-value: 8.01e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 768003900   4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
273-634 1.52e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 273 KPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKC--EECGKTFNRFSTLTTHKIIHTGEKPYKC-KECGKAFNRSSTLTTH 349
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 350 RKIHTGEKPYKCEECGKAFKQSSNLT--THKIIHTGEKPYK-CKKCGKAFNQSAHL-------------------TTHEV 407
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 408 IHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLT 487
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 488 EHKKIHTGE-------KPYECEKCGKAFNQSSNLTRHKKS--HTEE--KPYKCEE--CGKGFKWPSTLTIHKIIHTGEKP 554
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 555 YKC--EECGKAFNQSS-----KLTKHKKIHTGEKPYTCE--ECGKAFNQSSNLTKHKRIHTGEKP--YKCEECDKAFKWS 623
Cdd:COG5048  352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|.
gi 768003900 624 SVLTKHKIIHT 634
Cdd:COG5048  432 YNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
285-639 2.84e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 285 NQSSNLIKHKKIHTGE----KPYKCEECGKTFNRFSTLTTHKIIHTGEKPYKC--KECGKAFNRSSTLTTHRKIHTGEKP 358
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 359 YkcEECGKAFKQSSNLTTHKIIHTGEKPYKCKKC-GKAFNQSAHLTTHEVIHTGEKPYKCEKCGKAFNHFSHLTTHKIIH 437
Cdd:COG5048   92 D--LNSKSLPLSNSKASSSSLSSSSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 438 TGEKPYKCKEcgkAFKHSSTLTKHKIIHTGEKPYKCKECEKaFNQSSKLTEHKKIHTGEKPYECEKCGKAFNQSSNLTRH 517
Cdd:COG5048  170 PLPANSLSKD---PSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 518 KKSHTEEKPYKCEECGKGFKWPSTLTIHKIIHTGE-------KPYKCEECGKAFNQSSKLTKHK--KIHTGE--KPYTCE 586
Cdd:COG5048  246 SSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCP 325

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768003900 587 E--CGKAFNQSSNLTKHKRIHTGEKPYKCeecdkafKWSSVLTKHKIIHTGEKLQ 639
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFSPLLNNEPPQ 373
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-534 2.03e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 2.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 280 CGKAFNQSSNLIKHKKIHTGEKPYKCEECGKTfNRFSTLTTHKIIHTGEKPYKCKECGKAFNRSSTLTTHRKIHTGEKPY 359
Cdd:COG5048  177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSS-YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 360 KCEECGKAFKQSSNLTTHKIIHTGE-------KPYKCKKCGKAFNQSAHLTTH--EVIHTGE--KPYKC--EKCGKAFNH 426
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 427 FSHLTTHKIIHTGEKPYKCKECGKAFKHS--------STLTKHKIIHTGEKPYKC-KECEKAFNQSSKLTEHKKIHTGEK 497
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKLLNSSSKFSpllnneppQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFR 415

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 768003900 498 PYECE--KCGKAFNQSSNLTRHKKSHTEEKPYKCEECGK 534
Cdd:COG5048  416 PYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-603 9.13e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 189 KIFQCDKYVKVAHKFSNSNRHEIRHTKKKPFKCTK--CGKSFGMISCLTEHSRIHT-RVNFYKCEECGKAFNWSStltKH 265
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKAS---SS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 266 KRIHTGEKPYKCE-ECGKAFNQSSNLIKHKKIHTGEKPYKCEECGKTFNRFSTLTTHKIIHTGEKPYKCKEcgkAFNRSS 344
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 345 TLTTHRKIHTGEKPYKCEECGKA------------FKQSSNLTTHKIIHTGEKPYK---------------CKKCGKAFN 397
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLsqspsslsssdssssASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 398 QSAHLTTHEVIHTGE-------KPYKCEKCGKAFNHFSHLTTHK--IIHTGE--KPYKCKE--CGKAFKHSSTLTKHKII 464
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 465 HTGEKPYKCK--ECEKAFNQSS-----KLTEHKKIHTGEKPYECE--KCGKAFNQSSNLTRHKKSHTEEKPYKCeecgkg 535
Cdd:COG5048  346 HTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC------ 419

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768003900 536 fkwpstltihkiihtgekpyKCEECGKAFNQSSKLTKHKKIHTGEKPYTCEECGKaFNQSSNLTKHKR 603
Cdd:COG5048  420 --------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-520 9.80e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 9.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 357 KPYKCEECGKAFKQSSNLTTHK--IIHTGE--KPYKCKK--CGKAFNQSAHLTTHEVIHTGEKPYKC--EKCGKAFNHFS 428
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 429 ----HLTTHKIIHTGEKPYKC---KECGKAFKHSSTLTKHKIIHTGEKPY--KCKECEKAFNQSSKLTEHKKIHTGEKPY 499
Cdd:COG5048  368 nnepPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|.
gi 768003900 500 ECEKCGKaFNQSSNLTRHKKS 520
Cdd:COG5048  448 LCSILKS-FRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
597-621 1.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.29e-04
                          10        20
                  ....*....|....*....|....*
gi 768003900  597 NLTKHKRIHTGEKPYKCEECDKAFK 621
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 271-351 1.36e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 271 GEKPYKCE--ECGKAFnQSSNLIKHKKIHTGEKPYKCEECGKTfnrfstltTHKIIHTGEKPYKCKECGKAFNRSSTLTT 348
Cdd:COG5189  346 DGKPYKCPveGCNKKY-KNQNGLKYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 768003900 349 HRK 351
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 551-630 1.52e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 551 GEKPYKCE--ECGKAFNQSSKLTKHKKiHTGEKPYTCEecgkafnqSSNLTKHKRIHTGEKPYKCEECDKAFKWSSVLTK 628
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 768003900 629 HK 630
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 396-522 1.54e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 396 FNQSAHLTTHEVIH-------------TGE------KPYKCEKCGKAFNHFSHLT----THKIIHTGEKPYKCK--ECGK 450
Cdd:COG5189  280 FEESSLGFDYEFIHksvgnkeirggisTGEmidvrkLPCTNSSSNGKLAHGGERNidtpSRMLKVKDGKPYKCPveGCNK 359

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768003900 451 AFKHSSTLTKHKiihtgekpyKCKECEKAFNQSSKLTEHKKIHTGEKPYECEKCGKAFNQSSNLTRHKKSHT 522
Cdd:COG5189  360 KYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 495-575 2.05e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 495 GEKPYECE--KCGKAFNQSSNLTRHKKsHTEEKPYKCEEcgkgfkwPSTLTiHKIIHTGEKPYKCEECGKAFNQSSKLTK 572
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHEN-------PSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 768003900 573 HKK 575
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
262-286 3.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.06e-04
                          10        20
                  ....*....|....*....|....*
gi 768003900  262 LTKHKRIHTGEKPYKCEECGKAFNQ 286
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-314 3.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 768003900  289 NLIKHKKIHTGEKPYKCEECGKTFNR 314
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-454 5.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 768003900  429 HLTTHKIIHTGEKPYKCKECGKAFKH 454
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-398 9.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 768003900  373 NLTTHKIIHTGEKPYKCKKCGKAFNQ 398
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
346-370 9.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.83e-04
                          10        20
                  ....*....|....*....|....*
gi 768003900  346 LTTHRKIHTGEKPYKCEECGKAFKQ 370
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-537 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*
gi 768003900  513 NLTRHKKSHTEEKPYKCEECGKGFK 537
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
570-594 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*
gi 768003900  570 LTKHKKIHTGEKPYTCEECGKAFNQ 594
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 299-378 1.17e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003900 299 GEKPYKCE--ECGKTFNRFSTLTTHKiihtgekpyKCKECGKAFNRSSTLTTHRKIHTGEKPYKCEECGKAFKQSSNLTT 376
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 768003900 377 HK 378
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-510 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....*
gi 768003900  486 LTEHKKIHTGEKPYECEKCGKAFNQ 510
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-342 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....*
gi 768003900  318 LTTHKIIHTGEKPYKCKECGKAFNR 342
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
458-482 1.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.84e-03
                          10        20
                  ....*....|....*....|....*
gi 768003900  458 LTKHKIIHTGEKPYKCKECEKAFNQ 482
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-426 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 768003900  401 HLTTHEVIHTGEKPYKCEKCGKAFNH 426
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
542-566 3.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.70e-03
                          10        20
                  ....*....|....*....|....*
gi 768003900  542 LTIHKIIHTGEKPYKCEECGKAFNQ 566
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 583-605 8.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.16e-03
                          10        20
                  ....*....|....*....|...
gi 768003900  583 YTCEECGKAFNQSSNLTKHKRIH 605
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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