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Conserved domains on  [gi|830018835|ref|XP_012614557|]
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SUN domain-containing protein 1 isoform X3 [Microcebus murinus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 66-379 6.81e-58

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


:

Pssm-ID: 430576  Cd Length: 192  Bit Score: 196.71  E-value: 6.81e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835   66 GDGQAMGAHSCTSSAGSLKDGVARTVKQRRSANKVAFSINHVSRQVTSSGasqggskslqgavslrppvldeSLIReQTK 145
Cdd:pfam09387   5 ADGSALDAMNQNRRAQSWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR-QTK 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  146 VDHFWGLD----DDGDLKGGNKAAIQGNGDLAAGAAARNGYICSDCSMLSERrdaLTAHSTAHGLTSRIYSRDRDQKrgs 221
Cdd:pfam09387  62 VDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQK--- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  222 afymdrilwlakytsssfssflvqlfqvvlmklnyesENYKLKSDESKSYKSKNHESKAhpsycgtmnvkeslredghls 301
Cdd:pfam09387 136 -------------------------------------NTYTLKCTSTKPAQGQSQRSNA--------------------- 157

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 830018835  302 vngdslcyflmqtlrrigaagwfvsrtvwsvlwlalvapGKAASGMFWWLgigwYQFVTLISWLNVFLLTRCLRNFCK 379
Cdd:pfam09387 158 ---------------------------------------GKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 739-873 1.88e-55

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 187.50  E-value: 1.88e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  739 LWYFSQSPRVVIQPDMYPGNCWAFKGSQGYLVVRLSMVIHPTAVTLEHIPKTLsptgnITSAPKDFAVYGLENEYQEEGW 818
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 830018835  819 LLGHFTYDHEGESLQTFHVLKRPERAFQVVELRIFSNWGHPEYTCLYRFRVHGEP 873
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 505-561 2.74e-28

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


:

Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 107.75  E-value: 2.74e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 830018835 505 QHLWETDFMTFHQEHEVRISNLEDILGKLTEKSEAIQKELEQTKLKTTssSGADEQQ 561
Cdd:cd21439    1 QPLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTA--SGADEQQ 55
HTH_SUN2 super family cl39899
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 638-696 2.51e-11

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


The actual alignment was detected with superfamily member pfam18580:

Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 59.65  E-value: 2.51e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 830018835  638 LQILLQDLELKILKNITHHISVTKQMpTSETVMSAVNEAGVSGITEAQAHVIVNNALKL 696
Cdd:pfam18580   1 LQAQLQDLEQRILAKLAEEQGKSARD-AAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
CALCOCO1 super family cl37761
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 439-630 3.76e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


The actual alignment was detected with superfamily member pfam07888:

Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.20  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  439 QGDDEAFRWRWTRDVEQ---QVASLSGQCHSHDERLRELTALLEKLQAQVDQMDDGRAGLPAlVRDAVgqhlwetdfMTF 515
Cdd:pfam07888  54 NRQREKEKERYKRDREQwerQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSE-EKDAL---------LAQ 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  516 HQEHEVRISNLEDILGKLTEKSEAIQKELEQTKLKTTSSSG------ADEQQLMSTVRRLELELGHLRSELsswQHEKTS 589
Cdd:pfam07888 124 RAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAqrkeeeAERKQLQAKLQQTEEELRSLSKEF---QELRNS 200

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 830018835  590 CEKVDVSREKVDAQVRETLKLIFSEDQQDDSLEWLLQKFSS 630
Cdd:pfam07888 201 LAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRS 241
 
Name Accession Description Interval E-value
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 66-379 6.81e-58

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 196.71  E-value: 6.81e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835   66 GDGQAMGAHSCTSSAGSLKDGVARTVKQRRSANKVAFSINHVSRQVTSSGasqggskslqgavslrppvldeSLIReQTK 145
Cdd:pfam09387   5 ADGSALDAMNQNRRAQSWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR-QTK 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  146 VDHFWGLD----DDGDLKGGNKAAIQGNGDLAAGAAARNGYICSDCSMLSERrdaLTAHSTAHGLTSRIYSRDRDQKrgs 221
Cdd:pfam09387  62 VDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQK--- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  222 afymdrilwlakytsssfssflvqlfqvvlmklnyesENYKLKSDESKSYKSKNHESKAhpsycgtmnvkeslredghls 301
Cdd:pfam09387 136 -------------------------------------NTYTLKCTSTKPAQGQSQRSNA--------------------- 157

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 830018835  302 vngdslcyflmqtlrrigaagwfvsrtvwsvlwlalvapGKAASGMFWWLgigwYQFVTLISWLNVFLLTRCLRNFCK 379
Cdd:pfam09387 158 ---------------------------------------GKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 739-873 1.88e-55

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 187.50  E-value: 1.88e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  739 LWYFSQSPRVVIQPDMYPGNCWAFKGSQGYLVVRLSMVIHPTAVTLEHIPKTLsptgnITSAPKDFAVYGLENEYQEEGW 818
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 830018835  819 LLGHFTYDHEGESLQTFHVLKRPERAFQVVELRIFSNWGHPEYTCLYRFRVHGEP 873
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 505-561 2.74e-28

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 107.75  E-value: 2.74e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 830018835 505 QHLWETDFMTFHQEHEVRISNLEDILGKLTEKSEAIQKELEQTKLKTTssSGADEQQ 561
Cdd:cd21439    1 QPLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTA--SGADEQQ 55
HTH_SUN2 pfam18580
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 638-696 2.51e-11

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 59.65  E-value: 2.51e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 830018835  638 LQILLQDLELKILKNITHHISVTKQMpTSETVMSAVNEAGVSGITEAQAHVIVNNALKL 696
Cdd:pfam18580   1 LQAQLQDLEQRILAKLAEEQGKSARD-AAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 439-630 3.76e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.20  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  439 QGDDEAFRWRWTRDVEQ---QVASLSGQCHSHDERLRELTALLEKLQAQVDQMDDGRAGLPAlVRDAVgqhlwetdfMTF 515
Cdd:pfam07888  54 NRQREKEKERYKRDREQwerQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSE-EKDAL---------LAQ 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  516 HQEHEVRISNLEDILGKLTEKSEAIQKELEQTKLKTTSSSG------ADEQQLMSTVRRLELELGHLRSELsswQHEKTS 589
Cdd:pfam07888 124 RAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAqrkeeeAERKQLQAKLQQTEEELRSLSKEF---QELRNS 200

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 830018835  590 CEKVDVSREKVDAQVRETLKLIFSEDQQDDSLEWLLQKFSS 630
Cdd:pfam07888 201 LAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRS 241
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
451-652 3.82e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.60  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  451 RDVEQQVASLsgqchshdERLRELTALLEKLQAQVDQMDDGRAGLPALvRDAVGQHLWETDfmtfHQEHEVRISNLEDIL 530
Cdd:COG4913   245 EDAREQIELL--------EPIRELAERYAAARERLAELEYLRAALRLW-FAQRRLELLEAE----LEELRAELARLEAEL 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  531 GKLTEKSEAIQKELEQTKLKTTSSSGADEQQLMSTVRRLELELGHLRSELSSWQHEKTSCE-KVDVSREKVDAQVRETLK 609
Cdd:COG4913   312 ERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGlPLPASAEEFAALRAEAAA 391

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 830018835  610 LIfseDQQDDSLEWLLQKFSSQFVRKDDLQILLQDL--ELKILKN 652
Cdd:COG4913   392 LL---EALEEELEALEEALAEAEAALRDLRRELRELeaEIASLER 433
 
Name Accession Description Interval E-value
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 66-379 6.81e-58

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 196.71  E-value: 6.81e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835   66 GDGQAMGAHSCTSSAGSLKDGVARTVKQRRSANKVAFSINHVSRQVTSSGasqggskslqgavslrppvldeSLIReQTK 145
Cdd:pfam09387   5 ADGSALDAMNQNRRAQSWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR-QTK 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  146 VDHFWGLD----DDGDLKGGNKAAIQGNGDLAAGAAARNGYICSDCSMLSERrdaLTAHSTAHGLTSRIYSRDRDQKrgs 221
Cdd:pfam09387  62 VDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQK--- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  222 afymdrilwlakytsssfssflvqlfqvvlmklnyesENYKLKSDESKSYKSKNHESKAhpsycgtmnvkeslredghls 301
Cdd:pfam09387 136 -------------------------------------NTYTLKCTSTKPAQGQSQRSNA--------------------- 157

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 830018835  302 vngdslcyflmqtlrrigaagwfvsrtvwsvlwlalvapGKAASGMFWWLgigwYQFVTLISWLNVFLLTRCLRNFCK 379
Cdd:pfam09387 158 ---------------------------------------GKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 739-873 1.88e-55

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 187.50  E-value: 1.88e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  739 LWYFSQSPRVVIQPDMYPGNCWAFKGSQGYLVVRLSMVIHPTAVTLEHIPKTLsptgnITSAPKDFAVYGLENEYQEEGW 818
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 830018835  819 LLGHFTYDHEGESLQTFHVLKRPERAFQVVELRIFSNWGHPEYTCLYRFRVHGEP 873
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 505-561 2.74e-28

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 107.75  E-value: 2.74e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 830018835 505 QHLWETDFMTFHQEHEVRISNLEDILGKLTEKSEAIQKELEQTKLKTTssSGADEQQ 561
Cdd:cd21439    1 QPLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTA--SGADEQQ 55
SUN_cc1 cd21435
coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 ...
 505-556 4.11e-16

coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 and SUN2) are components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN proteins contain two coiled-coil domains (CC1 and CC2), which act as intrinsic dynamic regulators controlling the activity of the SUN domain. The model corresponds to CC1 that functions as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410603 [Multi-domain]  Cd Length: 55  Bit Score: 73.21  E-value: 4.11e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 830018835 505 QHLWETDFMTFHQEHEVRISNLEDILGKLTEKSEAIQKELEQTKLKTTSSSG 556
Cdd:cd21435    1 QEAFQESSVKELGRLEAQLASLRQELAALTLKQEAIQKELEQTKQKTISAVG 52
HTH_SUN2 pfam18580
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 638-696 2.51e-11

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 59.65  E-value: 2.51e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 830018835  638 LQILLQDLELKILKNITHHISVTKQMpTSETVMSAVNEAGVSGITEAQAHVIVNNALKL 696
Cdd:pfam18580   1 LQAQLQDLEQRILAKLAEEQGKSARD-AAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 439-630 3.76e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.20  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  439 QGDDEAFRWRWTRDVEQ---QVASLSGQCHSHDERLRELTALLEKLQAQVDQMDDGRAGLPAlVRDAVgqhlwetdfMTF 515
Cdd:pfam07888  54 NRQREKEKERYKRDREQwerQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSE-EKDAL---------LAQ 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  516 HQEHEVRISNLEDILGKLTEKSEAIQKELEQTKLKTTSSSG------ADEQQLMSTVRRLELELGHLRSELsswQHEKTS 589
Cdd:pfam07888 124 RAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAqrkeeeAERKQLQAKLQQTEEELRSLSKEF---QELRNS 200

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 830018835  590 CEKVDVSREKVDAQVRETLKLIFSEDQQDDSLEWLLQKFSS 630
Cdd:pfam07888 201 LAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRS 241
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
451-652 3.82e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.60  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  451 RDVEQQVASLsgqchshdERLRELTALLEKLQAQVDQMDDGRAGLPALvRDAVGQHLWETDfmtfHQEHEVRISNLEDIL 530
Cdd:COG4913   245 EDAREQIELL--------EPIRELAERYAAARERLAELEYLRAALRLW-FAQRRLELLEAE----LEELRAELARLEAEL 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  531 GKLTEKSEAIQKELEQTKLKTTSSSGADEQQLMSTVRRLELELGHLRSELSSWQHEKTSCE-KVDVSREKVDAQVRETLK 609
Cdd:COG4913   312 ERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGlPLPASAEEFAALRAEAAA 391

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 830018835  610 LIfseDQQDDSLEWLLQKFSSQFVRKDDLQILLQDL--ELKILKN 652
Cdd:COG4913   392 LL---EALEEELEALEEALAEAEAALRDLRRELRELeaEIASLER 433
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
452-658 6.04e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 6.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  452 DVEQQVASLSGQCHSHDERLRELTALLEKLQAQVDQMDDGRAGLPALVrdavgQHLW-ETDfmtfHQEHEVRISNLEDIL 530
Cdd:COG4913   607 DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLA-----EYSWdEID----VASAEREIAELEAEL 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835  531 GKLTEKS---EAIQKELEQTKlkttsssgADEQQLMSTVRRLELELGHLRSELSSWQHEKTSCE-KVDVSREKVDAQVRE 606
Cdd:COG4913   678 ERLDASSddlAALEEQLEELE--------AELEELEEELDELKGEIGRLEKELEQAEEELDELQdRLEAAEDLARLELRA 749

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 830018835  607 TLKLIFSEDQQDDSLEWLLQKFSSqfvRKDDLQILLQDLELKILKNITHHIS 658
Cdd:COG4913   750 LLEERFAAALGDAVERELRENLEE---RIDALRARLNRAEEELERAMRAFNR 798
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
451-609 3.36e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835 451 RDVEQQVASLS---GQCHSHDERLRELTALLEKLQAQVDQMDDGRAGLPALV--------RDAVGQHL-WETDFMTFHQE 518
Cdd:COG4717   74 KELEEELKEAEekeEEYAELQEELEELEEELEELEAELEELREELEKLEKLLqllplyqeLEALEAELaELPERLEELEE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835 519 HEVRISNLEDILGKLTEKSEAIQKELEQTKLKTTSSSGADEQQLMSTVRRLELELGHLRSELSSWQHEKTSCEKV--DVS 596
Cdd:COG4717  154 RLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEEleQLE 233

                        170
                 ....*....|...
gi 830018835 597 REKVDAQVRETLK 609
Cdd:COG4717  234 NELEAAALEERLK 246
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
443-582 4.90e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 40.39  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835 443 EAFRwrwtrdVEQQVASLSGQCHSHDERLRELTALLEKLQAQV-----------DQMDDGRAGLPALVRDAVGQHLWEtd 511
Cdd:COG3206  199 EEFR------QKNGLVDLSEEAKLLLQQLSELESQLAEARAELaeaearlaalrAQLGSGPDALPELLQSPVIQQLRA-- 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835 512 fmtfhQEHEVRiSNLEDILGKLTEKS----------EAIQKELEQTKLKTTSSSGADEQQLMSTVRRLELELGHLRSELS 581
Cdd:COG3206  271 -----QLAELE-AELAELSARYTPNHpdvialraqiAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLA 344


                 .
gi 830018835 582 S 582
Cdd:COG3206  345 E 345
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
447-562 7.64e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.75  E-value: 7.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835 447 WRWTRDVEQQVASLSGQCHSHDERLRELTALLEKLQAQVDQMDDGRAGLPALVRDAVGQHLWE-TDFMTFHQEHEVRISN 525
Cdd:COG4717  131 YQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLAE 210

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 830018835 526 LEDILGKLTEKSEAIQKELEQtkLKTTSSSGADEQQL 562
Cdd:COG4717  211 LEEELEEAQEELEELEEELEQ--LENELEAAALEERL 245
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 468-607 8.52e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.75  E-value: 8.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830018835 468 DERLRELTALLEKLQAQVDQMDDGRAGLPALVRDAVGQHlweTDFMTFHQEHEVRISNLEDILGKLTEKS---------E 538
Cdd:COG1579   16 DSELDRLEHRLKELPAELAELEDELAALEARLEAAKTEL---EDLEKEIKRLELEIEEVEARIKKYEEQLgnvrnnkeyE 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 830018835 539 AIQKELEQTKLKTTSSSgADEQQLMSTVRRLELELGHLRSELSSWQhektscEKVDVSREKVDAQVRET 607
Cdd:COG1579   93 ALQKEIESLKRRISDLE-DEILELMERIEELEEELAELEAELAELE------AELEEKKAELDEELAEL 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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