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Conserved domains on  [gi|1663449313|ref|XP_015666787|]
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artemin [Protobothrops mucrosquamatus]

Protein Classification

TGF-beta family protein( domain architecture ID 14443713)

transforming growth factor-beta (TGF-beta) family protein may control proliferation, differentiation, and other functions in many cell types

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 241-332 5.10e-56

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


:

Pssm-ID: 381651  Cd Length: 98  Bit Score: 177.16  E-value: 5.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 241 SHPINVRDLGLGYDSEEVVLFRYCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDH-ISQPCCRPILYENLSFLDVHNVWQ 319
Cdd:cd19381     6 SLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSLLKQGAIPPGPHERvSSQPCCRPTRYENVSFMDVQNVWQ 85

                          90
                  ....*....|...
gi 1663449313 320 DLQRVSAAECSCL 332
Cdd:cd19381    86 TVEKLSAAECSCV 98
 
Name Accession Description Interval E-value
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 241-332 5.10e-56

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 177.16  E-value: 5.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 241 SHPINVRDLGLGYDSEEVVLFRYCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDH-ISQPCCRPILYENLSFLDVHNVWQ 319
Cdd:cd19381     6 SLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSLLKQGAIPPGPHERvSSQPCCRPTRYENVSFMDVQNVWQ 85

                          90
                  ....*....|...
gi 1663449313 320 DLQRVSAAECSCL 332
Cdd:cd19381    86 TVEKLSAAECSCV 98
TGF_beta pfam00019
Transforming growth factor beta like domain;
244-331 3.26e-14

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 67.74  E-value: 3.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 244 INVRDLGL--------GYDseevvlFRYCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDHISQPCCRPILYENLSFLDVH 315
Cdd:pfam00019   9 VDFEDLGWddwiiapkGYN------AYYCSGSCPSHLNPQLSATNHAILQSLLHSLKPANVPKPCCVPTKLSPLSVLYYD 82

                          90       100
                  ....*....|....*....|
gi 1663449313 316 N----VWQDLQRVSAAECSC 331
Cdd:pfam00019  83 DegnvVLKTYPDMVVESCGC 102
 
Name Accession Description Interval E-value
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 241-332 5.10e-56

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 177.16  E-value: 5.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 241 SHPINVRDLGLGYDSEEVVLFRYCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDH-ISQPCCRPILYENLSFLDVHNVWQ 319
Cdd:cd19381     6 SLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSLLKQGAIPPGPHERvSSQPCCRPTRYENVSFMDVQNVWQ 85

                          90
                  ....*....|...
gi 1663449313 320 DLQRVSAAECSCL 332
Cdd:cd19381    86 TVEKLSAAECSCV 98
TGF_beta_Persephin cd19382
transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; ...
 244-333 1.87e-29

transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; Persephin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with neurotrophic activity on mesencephalic dopaminergic and motor neurons.


Pssm-ID: 381652  Cd Length: 99  Bit Score: 108.71  E-value: 1.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 244 INVRDLGLGYDSEEVVLFRYCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDHISQPCCRPILYENLSFLDVHNVWQDLQR 323
Cdd:cd19382    10 LRVGDLGLGYDSEETVLFKYCSGGCPRARTNHDLTLSRLLQKGDLPSLGEKIFGGPCCRPTHYEDVAFLDDNHRWHTVEK 89

                          90
                  ....*....|
gi 1663449313 324 VSAAECSCLG 333
Cdd:cd19382    90 LSAAACACVG 99
TGF_beta_GDNF_like cd13750
transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived ...
 241-331 2.25e-28

transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived neurotrophic factor (GDNF) family of ligands; GDNF family of ligands includes GDNF, Artemin, Neurturin, and Persephin. They plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis.


Pssm-ID: 381628  Cd Length: 95  Bit Score: 105.61  E-value: 2.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 241 SHPINVRDLGLGYDSEEVVLFRYCSGTCKLARNDYHEVLNHLVQEGIIVPkhNDHISQPCCRPILYEN-LSFLDVHNVWQ 319
Cdd:cd13750     6 ELHLRVTDLGLGYASEEEVIFRYCAGSCEAARTNYDLILANLRGWRRLRS--DRKVGQPCCRPTAYDDdVSFLDDNSRYH 83

                          90
                  ....*....|..
gi 1663449313 320 DLQRVSAAECSC 331
Cdd:cd13750    84 ILRKLSAKACGC 95
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 246-331 5.57e-27

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


Pssm-ID: 381653  Cd Length: 104  Bit Score: 102.08  E-value: 5.57e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 246 VRDLGLGYDSEEVVLFRYCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDHIS-QPCCRPILYE-NLSFLDVHNVWQDLQR 323
Cdd:cd19383    16 VSELGLGYESDETVLFRYCSGKCEAARRNYDLTLKHMRGKKSLKKGRKDKVRaRPCCRPTAYEdDVSFLDNNNRYHTIQE 95


                  ....*...
gi 1663449313 324 VSAAECSC 331
Cdd:cd19383    96 LSAKECGC 103
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 244-331 5.61e-24

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


Pssm-ID: 381650  Cd Length: 96  Bit Score: 94.14  E-value: 5.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 244 INVRDLGLGYDSEEVVLFRYCSGTCKLARNDYHEVLNHLVQEGIIVpkhNDHISQPCCRPILYE-NLSFLDVHNVWQDLQ 322
Cdd:cd19380    11 LNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLTRNKKLV---SDKVGQACCRPIAFDdDLSFLDDNLVYHTLK 87


                  ....*....
gi 1663449313 323 RVSAAECSC 331
Cdd:cd19380    88 KHSAKKCGC 96
TGF_beta pfam00019
Transforming growth factor beta like domain;
244-331 3.26e-14

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 67.74  E-value: 3.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 244 INVRDLGL--------GYDseevvlFRYCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDHISQPCCRPILYENLSFLDVH 315
Cdd:pfam00019   9 VDFEDLGWddwiiapkGYN------AYYCSGSCPSHLNPQLSATNHAILQSLLHSLKPANVPKPCCVPTKLSPLSVLYYD 82

                          90       100
                  ....*....|....*....|
gi 1663449313 316 N----VWQDLQRVSAAECSC 331
Cdd:pfam00019  83 DegnvVLKTYPDMVVESCGC 102
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 263-331 1.18e-06

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 46.54  E-value: 1.18e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1663449313 263 YCSGTCKLARNDYHEVLNH-LVQEGIIVPKHNDHISQPCCRPILYENLSFL----DVHNVWQDLQRVSAAECSC 331
Cdd:cd13756    29 YCAGSCPFPLSSHANATNHaILQALLHSLNPKKSVPKPCCVPTKYSPLSVLyydeDGNVVLKTYPDMVVEECGC 102
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 244-331 1.44e-04

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 40.54  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 244 INVRDLGLGYD--SEEVVLFRYCSGTCKlaRNDYHEVLNHLVqegIIVPKHNDHIS----QPCCRPILYENLSFLDVHN- 316
Cdd:cd08698     8 VNFKDLGGLNWiiAPSGFTANYCRGSCN--SESSATTNHTKL---LQWSRTRRHTPreelKPCCVPTSYEPLSILYYDNn 82

                          90
                  ....*....|....*...
gi 1663449313 317 ---VWQDLQRVSAAECSC 331
Cdd:cd08698    83 gtvVETLLPNLIVTECGC 100
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 247-331 4.64e-04

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 38.83  E-value: 4.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663449313 247 RDLGLGY-DSEEVVLFRYCSGTCKL---ARNDYHEVLNHLVQEgiivpkHNDHISQPCCRPILYENLSFLDVHN---VWQ 319
Cdd:cd13753    12 RDLGWKWiHEPKGFNANYCAGACPYlwsADTQHSTVLQLYNRL------NPVASAAPCCSPRELEPLTILYYDGrnpKIE 85

                          90
                  ....*....|..
gi 1663449313 320 DLQRVSAAECSC 331
Cdd:cd13753    86 TLSNMIVTSCKC 97
TGF_beta_GDP9_9B_like cd13762
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 261-331 7.64e-04

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381640  Cd Length: 104  Bit Score: 38.59  E-value: 7.64e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1663449313 261 FRYCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDHISQPCCRPILYENLSFL----DVHNVWQDLQRVSAAECSC 331
Cdd:cd13762    29 ANYCKGTCPRVLGQDLNPTNHAIVQNILHHLLDKSVPRPSCVPTELHPLSVLyyeeDGSIIYKEYPDMVASSCGC 103
TGF_beta_BMP5 cd19395
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 ...
 263-331 1.18e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.


Pssm-ID: 381665  Cd Length: 113  Bit Score: 38.14  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663449313 263 YCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDHISQPCCRPILYENLSFL---DVHNV-WQDLQRVSAAECSC 331
Cdd:cd19395    40 YCDGECSFPLNAHMNATNHAIVQTLVHLMFPDNVPKPCCAPTKLNAISVLyfdDSSNViLKKYRNMVVRSCGC 112
TGF_beta_NODAL cd13759
transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; ...
 264-331 1.53e-03

transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; NODAL is essential for mesoderm formation and axial patterning during embryonic development.


Pssm-ID: 381637  Cd Length: 103  Bit Score: 37.67  E-value: 1.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1663449313 264 CSGTCKLARNDYHEVLNHLVQEGIIVPKHNDHISQPCCRPILYENLSFLDVHN---VWQDLQRVSAAECSC 331
Cdd:cd13759    32 CEGECPSPVDEDFKPTNHAYMQSLLKLYQPDRVPLPCCVPTKLSPLSMLYYEHgevVVRHHEDMIVEECGC 102
TGF_beta_INHB cd13752
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ...
 263-331 3.35e-03

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381630  Cd Length: 100  Bit Score: 36.48  E-value: 3.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1663449313 263 YCSGTCK----LARNDYHEVLNHLVQEgiivpKHNDHISQPCCRPILYENLSFLDVHN----VWQDLQRVSAAECSC 331
Cdd:cd13752    29 YCKGSCSgsssPFRSHHTTILQKYLSK-----NKAKSELTPCCTPTKMSPLSLLYYDSdgniVKKDLPNMIVESCGC 100
TGF_beta_BMP7 cd19397
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 ...
 263-331 4.46e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.


Pssm-ID: 381667  Cd Length: 107  Bit Score: 36.18  E-value: 4.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663449313 263 YCSGTCKLARNDYHEVLNHLVQEGIIVPKHNDHISQPCCRPILYENLSFL---DVHNV-WQDLQRVSAAECSC 331
Cdd:cd19397    34 YCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLyfdDSSNViLKKYRNMVVRACGC 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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