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Conserved domains on  [gi|1034572500|ref|XP_016872858|]
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centrosomal protein of 164 kDa isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1167-1652 1.57e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 1.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQV--LEQDQRHLLESKQEKMQQLREKlcQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARM 1244
Cdd:COG1196    280 ELELEEAQAEEYELLAELarLEQDIARLEERRRELEERLEEL--EEELAELEEELEELEEELEELEEELEEAEEELEEAE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1245 REEESQRLSwlRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQM-LEQLKEEIEASEKSEQAALN 1323
Cdd:COG1196    358 AELAEAEEA--LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLErLERLEEELEELEEALAELEE 435

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1324 AAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQ--------------L 1389
Cdd:COG1196    436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEadyegflegvkaalL 515

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1390 QKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEH-QQVMAKAREQYEAEERKQRAELLGHLTG 1468
Cdd:COG1196    516 LAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARG 595

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1469 ELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQV 1548
Cdd:COG1196    596 AIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1549 ALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQsqqlqkhfssLEAEAQKKQHLLREV 1628
Cdd:COG1196    676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL----------EAEREELLEELLEEE 745

                          490       500
                   ....*....|....*....|....
gi 1034572500 1629 TVEENNASPHFEPDLHIEDLRKSL 1652
Cdd:COG1196    746 ELLEEEALEELPEPPDLEELEREL 769
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 59-89 7.04e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


:

Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 44.44  E-value: 7.04e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034572500   59 PGEWKPCQDITGDIYYFNFANGQSMWDHPCD 89
Cdd:cd00201      1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 823-1190 1.50e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 1.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  823 SQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLSSAvgkgRQGSGARPGLPEKEENEKSEPKicRNLVTPKADPTGSEPA 902
Cdd:PHA03307    45 SDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAP----ANESRSTPTWSLSTLAPASPAR--EGSPTPPGPSSPDPPP 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  903 KASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQEleiSEHMKEPQLSDSIASDPKSFHGL-----DFGF 977
Cdd:PHA03307   119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA---SDAASSRQAALPLSSPEETARAPssppaEPPP 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  978 RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEESSLPALQMEGPDSAALPGLTRLSPPl 1057
Cdd:PHA03307   196 STPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASG- 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1058 PHEERAQSPPRSlatEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSqaeeLGPGQEE 1137
Cdd:PHA03307   275 WNGPSSRPGPAS---SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA----VSPGPSP 347

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1138 AEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQR 1190
Cdd:PHA03307   348 SRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARR 400
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1167-1652 1.57e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 1.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQV--LEQDQRHLLESKQEKMQQLREKlcQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARM 1244
Cdd:COG1196    280 ELELEEAQAEEYELLAELarLEQDIARLEERRRELEERLEEL--EEELAELEEELEELEEELEELEEELEEAEEELEEAE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1245 REEESQRLSwlRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQM-LEQLKEEIEASEKSEQAALN 1323
Cdd:COG1196    358 AELAEAEEA--LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLErLERLEEELEELEEALAELEE 435

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1324 AAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQ--------------L 1389
Cdd:COG1196    436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEadyegflegvkaalL 515

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1390 QKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEH-QQVMAKAREQYEAEERKQRAELLGHLTG 1468
Cdd:COG1196    516 LAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARG 595

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1469 ELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQV 1548
Cdd:COG1196    596 AIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1549 ALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQsqqlqkhfssLEAEAQKKQHLLREV 1628
Cdd:COG1196    676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL----------EAEREELLEELLEEE 745

                          490       500
                   ....*....|....*....|....
gi 1034572500 1629 TVEENNASPHFEPDLHIEDLRKSL 1652
Cdd:COG1196    746 ELLEEEALEELPEPPDLEELEREL 769
PTZ00121 PTZ00121
MAEBL; Provisional
 899-1627 6.59e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.44  E-value: 6.59e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  899 SEPAKASEKEAPEDTVDAGEEGSRREEAAK-EPKKKASalEEGSSDASQELEISEHMKEPQLSDSI--ASDPKSFHGLDF 975
Cdd:PTZ00121  1106 TETGKAEEARKAEEAKKKAEDARKAEEARKaEDARKAE--EARKAEDAKRVEIARKAEDARKAEEArkAEDAKKAEAARK 1183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  976 GFRSRISEHLLDVDVLSPVlgGACRQAQQPLGIEDkddSQSSQDELQSKQSKGLEESSLPALQMEGPDSAALPGLTRLSP 1055
Cdd:PTZ00121  1184 AEEVRKAEELRKAEDARKA--EAARKAEEERKAEE---ARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFE 1258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1056 PLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQ 1135
Cdd:PTZ00121  1259 EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKA 1338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1136 EEAEDPEEkvavsptppvspeVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKlcqeeeeei 1215
Cdd:PTZ00121  1339 EEAKKAAE-------------AAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEA--------- 1396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1216 lrlhQQKEQSLSSLRERLQKAieeeearmrEEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERAS 1295
Cdd:PTZ00121  1397 ----KKKAEEDKKKADELKKA---------AAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAK 1463

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1296 LEQKNRQMLEQLKEEIEASEKSEQAALNA--AKEKAlQQLREQLEgERKEAVATLEKEHSAELERLCSSLEAKHREVVss 1373
Cdd:PTZ00121  1464 KKAEEAKKADEAKKKAEEAKKADEAKKKAeeAKKKA-DEAKKAAE-AKKKADEAKKAEEAKKADEAKKAEEAKKADEA-- 1539

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1374 lqKKIQEAQQKEEAQLQKCLGQVEHRvhQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEA 1453
Cdd:PTZ00121  1540 --KKAEEKKKADELKKAEELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA 1615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1454 EERKQRAELLGHLTGELERLQRAHERELETVRQ-EQHKRLEDLRRRHREQERKlqdleldletRAKDVKARLALLEVQEE 1532
Cdd:PTZ00121  1616 EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKaEELKKAEEENKIKAAEEAK----------KAEEDKKKAEEAKKAEE 1685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1533 TARREKQQLLDvqrqvalKSEEAtathQQLEEAQKEHTHLLQSNQQLREildELQARKLKLEsQVDLLQAQSQQLQKHFS 1612
Cdd:PTZ00121  1686 DEKKAAEALKK-------EAEEA----KKAEELKKKEAEEKKKAEELKK---AEEENKIKAE-EAKKEAEEDKKKAEEAK 1750

                          730
                   ....*....|....*
gi 1034572500 1613 SLEAEAQKKQHLLRE 1627
Cdd:PTZ00121  1751 KDEEEKKKIAHLKKE 1765
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1187-1782 2.80e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.49  E-value: 2.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1187 QDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQsLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQAD 1266
Cdd:TIGR02168  308 RERLANLERQLEELEAQLEELESKLDELAEELAELEEK-LEELKEELESLEAELEELEAELEELESRLEELEEQLETLRS 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1267 E-DQIRaEQEASLQKLREELESQQKAERASLEqKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEgeRKEAV 1345
Cdd:TIGR02168  387 KvAQLE-LQIASLNNEIERLEARLERLEDRRE-RLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELE--RLEEA 462

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1346 ATLEKEHSAELERLCSSLEAKHREVVSslQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV----------AGYEHELS 1415
Cdd:TIGR02168  463 LEELREELEEAEQALDAAERELAQLQA--RLDSLERLQENLEGFSEGVKALLKNQSGLSGILgvlselisvdEGYEAAIE 540

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1416 SLLREKRQEVEGEHE----------------------------------RRLDKMKEEHQQVMAKAREQYEAEERKQRAE 1461
Cdd:TIGR02168  541 AALGGRLQAVVVENLnaakkaiaflkqnelgrvtflpldsikgteiqgnDREILKNIEGFLGVAKDLVKFDPKLRKALSY 620

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1462 LLGH------LTGELERLQRAHEREL----------------------ETVRQEQHKRLEDLRRRHREQERKLQDLEL-- 1511
Cdd:TIGR02168  621 LLGGvlvvddLDNALELAKKLRPGYRivtldgdlvrpggvitggsaktNSSILERRREIEELEEKIEELEEKIAELEKal 700

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1512 -DLETRAKDVKARLALLEVQEETARRE----KQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDEL 1586
Cdd:TIGR02168  701 aELRKELEELEEELEQLRKELEELSRQisalRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA 780

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1587 QARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK-KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLS 1665
Cdd:TIGR02168  781 EAEIEELEAQIEQLKEELKALREALDELRAELTLlNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAE 860

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1666 QSKEDLYLDSLSSHNVWHL-----LSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVakdppgIKAL 1740
Cdd:TIGR02168  861 IEELEELIEELESELEALLnerasLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELR------LEGL 934

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 1034572500 1741 EDMRKNL-----EKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSL 1782
Cdd:TIGR02168  935 EVRIDNLqerlsEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKI 981
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1273-1590 8.88e-15

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 80.17  E-value: 8.88e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1273 EQEASLQKLREELESQQKAERASLEQKNRQMLE-----QLKEEIEASEKSEQAALNAAKEKALQQLREQ-----LEGERK 1342
Cdd:pfam17380  288 QQQEKFEKMEQERLRQEKEEKAREVERRRKLEEaekarQAEMDRQAAIYAEQERMAMERERELERIRQEerkreLERIRQ 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1343 EAVAtLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQlqkclgqveHRVHQKSYHVAGYEHELSSLLREKR 1422
Cdd:pfam17380  368 EEIA-MEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQ---------RKIQQQKVEMEQIRAEQEEARQREV 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1423 QEVEGEHERRLDKMKEEH---QQVMAKAREQYEAEERKQRaellghltgELERLQRAHERELETVRQEQHKRLEDLRRRH 1499
Cdd:pfam17380  438 RRLEEERAREMERVRLEEqerQQQVERLRQQEEERKRKKL---------ELEKEKRDRKRAEEQRRKILEKELEERKQAM 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1500 REQERKLQDLELDLETRAKDVKARLALLEVQEEtarREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHthllqsnQQL 1579
Cdd:pfam17380  509 IEEERKRKLLEKEMEERQKAIYEEERRREAEEE---RRKQQEMEERRRIQEQMRKATEERSRLEAMERER-------EMM 578

                          330
                   ....*....|.
gi 1034572500 1580 REILDELQARK 1590
Cdd:pfam17380  579 RQIVESEKARA 589
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 59-89 7.04e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 44.44  E-value: 7.04e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034572500   59 PGEWKPCQDITGDIYYFNFANGQSMWDHPCD 89
Cdd:cd00201      1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 823-1190 1.50e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 1.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  823 SQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLSSAvgkgRQGSGARPGLPEKEENEKSEPKicRNLVTPKADPTGSEPA 902
Cdd:PHA03307    45 SDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAP----ANESRSTPTWSLSTLAPASPAR--EGSPTPPGPSSPDPPP 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  903 KASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQEleiSEHMKEPQLSDSIASDPKSFHGL-----DFGF 977
Cdd:PHA03307   119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA---SDAASSRQAALPLSSPEETARAPssppaEPPP 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  978 RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEESSLPALQMEGPDSAALPGLTRLSPPl 1057
Cdd:PHA03307   196 STPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASG- 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1058 PHEERAQSPPRSlatEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSqaeeLGPGQEE 1137
Cdd:PHA03307   275 WNGPSSRPGPAS---SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA----VSPGPSP 347

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1138 AEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQR 1190
Cdd:PHA03307   348 SRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARR 400
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 58-87 1.73e-05

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 43.26  E-value: 1.73e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1034572500   58 LPGEWKPCQDITGDIYYFNFANGQSMWDHP 87
Cdd:pfam00397    1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 57-87 4.31e-05

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 42.20  E-value: 4.31e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1034572500    57 PLPGEWKPCQDITGDIYYFNFANGQSMWDHP 87
Cdd:smart00456    1 PLPPGWEERKDPDGRPYYYNHETKETQWEKP 31
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1268-1461 7.61e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 48.29  E-value: 7.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1268 DQIRAEQEASLQ--KLREELESQQKAERASLEQK----NRQMLEQLKEEIEASEKSEQAALNAAKEKAL----QQLREQL 1337
Cdd:NF012221  1532 DNVVATSESSQQadAVSKHAKQDDAAQNALADKEraeaDRQRLEQEKQQQLAAISGSQSQLESTDQNALetngQAQRDAI 1611

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1338 EGERKEAVATLEK------------EHSAEL---------ERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQkclgQV 1396
Cdd:NF012221  1612 LEESRAVTKELTTlaqgldaldsqaTYAGESgdqwrnpfaGGLLDRVQEQLDDAKKISGKQLADAKQRHVDNQQ----KV 1687

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1397 EHRVHQKSYHVA-GYEHELSSLLREKRQEVEGEhERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 1461
Cdd:NF012221  1688 KDAVAKSEAGVAqGEQNQANAEQDIDDAKADAE-KRKDDALAKQNEAQQAESDANAAANDAQSRGE 1752
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1374-1545 1.85e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 45.65  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1374 LQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV-AGY------------------------EHELSSLLREKrqEVEGE 1428
Cdd:cd16269    107 CKQNEEASSKRCQALLQELSAPLEEKISQGSYSVpGGYqlyledreklvekyrqvprkgvkaEEVLQEFLQSK--EAEAE 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1429 HERRLDKMKEEHQQVMAKAREQYEAEErkQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQD 1508
Cdd:cd16269    185 AILQADQALTEKEKEIEAERAKAEAAE--QERKLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEEERENLLKEQERALE 262

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1034572500 1509 LELDLETRakdvkarlALLEVQEETARREKQQLLDVQ 1545
Cdd:cd16269    263 SKLKEQEA--------LLEEGFKEQAELLQEEIRSLK 291
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1279-1384 5.65e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 42.19  E-value: 5.65e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  1279 QKLREELESQQKAERASLEQKNRQmLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKehsaeler 1358
Cdd:smart00935   17 KAAQKQLEKEFKKRQAELEKLEKE-LQKLKEKLQKDAATLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQK-------- 87

                            90       100
                    ....*....|....*....|....*.
gi 1034572500  1359 lcssleaKHREVVSSLQKKIQEAQQK 1384
Cdd:smart00935   88 -------RQQEELQKILDKINKAIKE 106
growth_prot_Scy NF041483
polarized growth protein Scy;
1249-1573 4.49e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 42.12  E-value: 4.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1249 SQRLSWLRAQVQSSTQAdedQIRAEQEASLQKLREEL-ESQQKAE-------------RASLEQKNRQMLEQLKEEIEAS 1314
Cdd:NF041483   103 TQRILQEHAEHQARLQA---ELHTEAVQRRQQLDQELaERRQTVEshvnenvawaeqlRARTESQARRLLDESRAEAEQA 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1315 EKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK-----------------EHSAELERLCSSL-----EAKHR--EV 1370
Cdd:NF041483   180 LAAARAEAERLAEEARQRLGSEAESARAEAEAILRRarkdaerllnaastqaqEATDHAEQLRSSTaaesdQARRQaaEL 259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1371 VSSLQKKIQEAQQK---EEAQLQKCLGQVEHRVHQKsyhVAGYEHELSSLLREKRQEVE---GEHERRLDKMKEEHQQVM 1444
Cdd:NF041483   260 SRAAEQRMQEAEEAlreARAEAEKVVAEAKEAAAKQ---LASAESANEQRTRTAKEEIArlvGEATKEAEALKAEAEQAL 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1445 AKAREQYE-----AEERKQRA-----------------ELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQ 1502
Cdd:NF041483   337 ADARAEAEklvaeAAEKARTVaaedtaaqlakaartaeEVLTKASEDAKATTRAAAEEAERIRREAEAEADRLRGEAADQ 416

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034572500 1503 ERKLQDLELD--LETRAKDVkarlallEVQEEtARR---EKQQLLD--VQRQVALKSEEATATHQQLEEAQKEHTHLL 1573
Cdd:NF041483   417 AEQLKGAAKDdtKEYRAKTV-------ELQEE-ARRlrgEAEQLRAeaVAEGERIRGEARREAVQQIEEAARTAEELL 486
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1167-1652 1.57e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 1.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQV--LEQDQRHLLESKQEKMQQLREKlcQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARM 1244
Cdd:COG1196    280 ELELEEAQAEEYELLAELarLEQDIARLEERRRELEERLEEL--EEELAELEEELEELEEELEELEEELEEAEEELEEAE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1245 REEESQRLSwlRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQM-LEQLKEEIEASEKSEQAALN 1323
Cdd:COG1196    358 AELAEAEEA--LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLErLERLEEELEELEEALAELEE 435

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1324 AAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQ--------------L 1389
Cdd:COG1196    436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEadyegflegvkaalL 515

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1390 QKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEH-QQVMAKAREQYEAEERKQRAELLGHLTG 1468
Cdd:COG1196    516 LAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARG 595

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1469 ELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQV 1548
Cdd:COG1196    596 AIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1549 ALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQsqqlqkhfssLEAEAQKKQHLLREV 1628
Cdd:COG1196    676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL----------EAEREELLEELLEEE 745

                          490       500
                   ....*....|....*....|....
gi 1034572500 1629 TVEENNASPHFEPDLHIEDLRKSL 1652
Cdd:COG1196    746 ELLEEEALEELPEPPDLEELEREL 769
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1217-1786 5.71e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 94.23  E-value: 5.71e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1217 RLHQQKEQSLS--SLRERLQKAIEEEEARMREEESQRLSWLRAQVQSsTQADEDQIRAEQEAsLQKLREELESQQKAERA 1294
Cdd:COG1196    204 PLERQAEKAERyrELKEELKELEAELLLLKLRELEAELEELEAELEE-LEAELEELEAELAE-LEAELEELRLELEELEL 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1295 SLEQKNRQmLEQLKEEIEASEKseQAALNAAKEKALQQLREQLEGERKEAVATLEkEHSAELERLCSSLEAkhrevvssl 1374
Cdd:COG1196    282 ELEEAQAE-EYELLAELARLEQ--DIARLEERRRELEERLEELEEELAELEEELE-ELEEELEELEEELEE--------- 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1375 QKKIQEAQQKEEAQLQKclgqvehrvhqksyhvagyehELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAE 1454
Cdd:COG1196    349 AEEELEEAEAELAEAEE---------------------ALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEE 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1455 ERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETA 1534
Cdd:COG1196    408 AEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELA 487

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1535 RREKQQLLDvqrqvalksEEATATHQQLEEAQKEhTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSL 1614
Cdd:COG1196    488 EAAARLLLL---------LEAEADYEGFLEGVKA-ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDE 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1615 EAEAQ----KKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEvssslsqskEDLYLDSLSSHNVWHLLSAEGV 1690
Cdd:COG1196    558 VAAAAieylKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVAS---------DLREADARYYVLGDTLLGRTLV 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1691 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKK 1770
Cdd:COG1196    629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                          570
                   ....*....|....*.
gi 1034572500 1771 KEEKLNQLESSLWEEA 1786
Cdd:COG1196    709 LAEAEEERLEEELEEE 724
PTZ00121 PTZ00121
MAEBL; Provisional
 899-1627 6.59e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.44  E-value: 6.59e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  899 SEPAKASEKEAPEDTVDAGEEGSRREEAAK-EPKKKASalEEGSSDASQELEISEHMKEPQLSDSI--ASDPKSFHGLDF 975
Cdd:PTZ00121  1106 TETGKAEEARKAEEAKKKAEDARKAEEARKaEDARKAE--EARKAEDAKRVEIARKAEDARKAEEArkAEDAKKAEAARK 1183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  976 GFRSRISEHLLDVDVLSPVlgGACRQAQQPLGIEDkddSQSSQDELQSKQSKGLEESSLPALQMEGPDSAALPGLTRLSP 1055
Cdd:PTZ00121  1184 AEEVRKAEELRKAEDARKA--EAARKAEEERKAEE---ARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFE 1258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1056 PLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQ 1135
Cdd:PTZ00121  1259 EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKA 1338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1136 EEAEDPEEkvavsptppvspeVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKlcqeeeeei 1215
Cdd:PTZ00121  1339 EEAKKAAE-------------AAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEA--------- 1396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1216 lrlhQQKEQSLSSLRERLQKAieeeearmrEEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERAS 1295
Cdd:PTZ00121  1397 ----KKKAEEDKKKADELKKA---------AAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAK 1463

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1296 LEQKNRQMLEQLKEEIEASEKSEQAALNA--AKEKAlQQLREQLEgERKEAVATLEKEHSAELERLCSSLEAKHREVVss 1373
Cdd:PTZ00121  1464 KKAEEAKKADEAKKKAEEAKKADEAKKKAeeAKKKA-DEAKKAAE-AKKKADEAKKAEEAKKADEAKKAEEAKKADEA-- 1539

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1374 lqKKIQEAQQKEEAQLQKCLGQVEHRvhQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEA 1453
Cdd:PTZ00121  1540 --KKAEEKKKADELKKAEELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA 1615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1454 EERKQRAELLGHLTGELERLQRAHERELETVRQ-EQHKRLEDLRRRHREQERKlqdleldletRAKDVKARLALLEVQEE 1532
Cdd:PTZ00121  1616 EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKaEELKKAEEENKIKAAEEAK----------KAEEDKKKAEEAKKAEE 1685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1533 TARREKQQLLDvqrqvalKSEEAtathQQLEEAQKEHTHLLQSNQQLREildELQARKLKLEsQVDLLQAQSQQLQKHFS 1612
Cdd:PTZ00121  1686 DEKKAAEALKK-------EAEEA----KKAEELKKKEAEEKKKAEELKK---AEEENKIKAE-EAKKEAEEDKKKAEEAK 1750

                          730
                   ....*....|....*
gi 1034572500 1613 SLEAEAQKKQHLLRE 1627
Cdd:PTZ00121  1751 KDEEEKKKIAHLKKE 1765
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1167-1750 1.99e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 89.23  E-value: 1.99e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLcQEEEEEILRL---HQQKEQSLSSLRERLQKAIEEEEAR 1243
Cdd:COG1196    222 LKELEAELLLLKLRELEAELEELEAELEELEAELEELEAEL-AELEAELEELrleLEELELELEEAQAEEYELLAELARL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1244 MREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLE--QKNRQMLEQLKEEIEASEKSEQAA 1321
Cdd:COG1196    301 EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEeaEAELAEAEEALLEAEAELAEAEEE 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1322 LNAAKEKALQQLREQLEGERKEA-VATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRV 1400
Cdd:COG1196    381 LEELAEELLEALRAAAELAAQLEeLEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEA 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1401 HQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLtGELERLQRAHERE 1480
Cdd:COG1196    461 LLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAV-AVLIGVEAAYEAA 539

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1481 LETVRQEQhkrledLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEAtathq 1560
Cdd:COG1196    540 LEAALAAA------LQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDL----- 608

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1561 qLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENnasphfe 1640
Cdd:COG1196    609 -READARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAE------- 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1641 pdlhIEDLRKSLGTNQTKEVSSSLSQSKEDLyldslsshnvwHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHW 1720
Cdd:COG1196    681 ----LEELAERLAEEELELEEALLAEEEEER-----------ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEE 745

                          570       580       590
                   ....*....|....*....|....*....|
gi 1034572500 1721 RHELASAQEVAKDPPGIKALEDMRKNLEKE 1750
Cdd:COG1196    746 ELLEEEALEELPEPPDLEELERELERLERE 775
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1168-1598 2.48e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 88.84  E-value: 2.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1168 QLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKlcQEEEEEILRLhQQKEQSLSSLRERLQKAIEEEEARMREE 1247
Cdd:COG1196    357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA--AELAAQLEEL-EEAEEALLERLERLEEELEELEEALAEL 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1248 ESQRLSWLRAQVQ-SSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRqmLEQLKEEIEASEKSEQAALNAAK 1326
Cdd:COG1196    434 EEEEEEEEEALEEaAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE--AAARLLLLLEAEADYEGFLEGVK 511

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1327 EKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKC-LGQVEHRVHQKSY 1405
Cdd:COG1196    512 AALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLpLDKIRARAALAAA 591

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1406 HVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEhqqVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVR 1485
Cdd:COG1196    592 LARGAIGAAVDLVASDLREADARYYVLGDTLLGR---TLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRR 668

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1486 QEQHKRLEDLRRRhREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEAtatHQQLEEA 1565
Cdd:COG1196    669 ELLAALLEAEAEL-EELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREEL---LEELLEE 744

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1034572500 1566 QKEHTHLLQSNQQLREILDELQARKLKLESQVD 1598
Cdd:COG1196    745 EELLEEEALEELPEPPDLEELERELERLEREIE 777
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1187-1782 2.80e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.49  E-value: 2.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1187 QDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQsLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQAD 1266
Cdd:TIGR02168  308 RERLANLERQLEELEAQLEELESKLDELAEELAELEEK-LEELKEELESLEAELEELEAELEELESRLEELEEQLETLRS 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1267 E-DQIRaEQEASLQKLREELESQQKAERASLEqKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEgeRKEAV 1345
Cdd:TIGR02168  387 KvAQLE-LQIASLNNEIERLEARLERLEDRRE-RLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELE--RLEEA 462

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1346 ATLEKEHSAELERLCSSLEAKHREVVSslQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV----------AGYEHELS 1415
Cdd:TIGR02168  463 LEELREELEEAEQALDAAERELAQLQA--RLDSLERLQENLEGFSEGVKALLKNQSGLSGILgvlselisvdEGYEAAIE 540

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1416 SLLREKRQEVEGEHE----------------------------------RRLDKMKEEHQQVMAKAREQYEAEERKQRAE 1461
Cdd:TIGR02168  541 AALGGRLQAVVVENLnaakkaiaflkqnelgrvtflpldsikgteiqgnDREILKNIEGFLGVAKDLVKFDPKLRKALSY 620

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1462 LLGH------LTGELERLQRAHEREL----------------------ETVRQEQHKRLEDLRRRHREQERKLQDLEL-- 1511
Cdd:TIGR02168  621 LLGGvlvvddLDNALELAKKLRPGYRivtldgdlvrpggvitggsaktNSSILERRREIEELEEKIEELEEKIAELEKal 700

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1512 -DLETRAKDVKARLALLEVQEETARRE----KQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDEL 1586
Cdd:TIGR02168  701 aELRKELEELEEELEQLRKELEELSRQisalRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA 780

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1587 QARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK-KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLS 1665
Cdd:TIGR02168  781 EAEIEELEAQIEQLKEELKALREALDELRAELTLlNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAE 860

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1666 QSKEDLYLDSLSSHNVWHL-----LSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVakdppgIKAL 1740
Cdd:TIGR02168  861 IEELEELIEELESELEALLnerasLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELR------LEGL 934

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 1034572500 1741 EDMRKNL-----EKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSL 1782
Cdd:TIGR02168  935 EVRIDNLqerlsEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKI 981
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1330-1628 3.71e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.99  E-value: 3.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1330 LQQLREQLEGERKEAVATLE-KEHSAELERLCSSLEAKHREVVSSLQKKIQ---EAQQKEEAQLQKCLGQVEHRVHQksy 1405
Cdd:COG1196    195 LGELERQLEPLERQAEKAERyRELKEELKELEAELLLLKLRELEAELEELEaelEELEAELEELEAELAELEAELEE--- 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1406 hvAGYEHELSSLLREKRQEVEGEHERRLDKM--KEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHE----- 1478
Cdd:COG1196    272 --LRLELEELELELEEAQAEEYELLAELARLeqDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEeleea 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1479 ----RELETVRQEQHKRLEDLRRRHREQERKLQDL---ELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALK 1551
Cdd:COG1196    350 eeelEEAEAELAEAEEALLEAEAELAEAEEELEELaeeLLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1552 SEEAT----ATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1627
Cdd:COG1196    430 LAELEeeeeEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509


                   .
gi 1034572500 1628 V 1628
Cdd:COG1196    510 V 510
PTZ00121 PTZ00121
MAEBL; Provisional
 1074-1785 4.29e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 85.19  E-value: 4.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1074 EEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVsptppv 1153
Cdd:PTZ00121  1112 EEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAE------ 1185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1154 spEVRSTEPVAPPEQL--SEAALKAMEEAVAqvlEQDQRHLLESKQEKMQQLREklcqeeeeeilrLHQQKEQSLSSLRE 1231
Cdd:PTZ00121  1186 --EVRKAEELRKAEDArkAEAARKAEEERKA---EEARKAEDAKKAEAVKKAEE------------AKKDAEEAKKAEEE 1248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1232 RLQKAIEEEEARMREEESQRLSWLRAQvqSSTQADEDQiRAEQEASLQKLREElESQQKAERASLEQKNRQMLEQLKEEI 1311
Cdd:PTZ00121  1249 RNNEEIRKFEEARMAHFARRQAAIKAE--EARKADELK-KAEEKKKADEAKKA-EEKKKADEAKKKAEEAKKADEAKKKA 1324

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1312 EASEKSEQAALNAAKE--KALQQLREQLEGERKEAVATLEKEHSAELERLcsslEAKHRevVSSLQKKIQEAQQKEEAQl 1389
Cdd:PTZ00121  1325 EEAKKKADAAKKKAEEakKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKE----EAKKK--ADAAKKKAEEKKKADEAK- 1397

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1390 qkclgqvehrvhQKSYHVAGYEHELSSLLREKRQEVE----GEHERRLDKMKEehqqvmaKAREQYEAEERKQRAELLGH 1465
Cdd:PTZ00121  1398 ------------KKAEEDKKKADELKKAAAAKKKADEakkkAEEKKKADEAKK-------KAEEAKKADEAKKKAEEAKK 1458

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1466 LTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLAllevqeETARREKQqlldvq 1545
Cdd:PTZ00121  1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKA------EEAKKADE------ 1526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1546 rqvALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQvdllqaqsqqlQKHFSSLEAEAQKKqhlL 1625
Cdd:PTZ00121  1527 ---AKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEE-----------DKNMALRKAEEAKK---A 1589

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1626 REVTVEENNASPHFEPDLHIEDLRKSlgtNQTKEVSSSLSQSKEDlyldslsSHNVWHLLSAEGVALRSAKEFL-VQQTR 1704
Cdd:PTZ00121  1590 EEARIEEVMKLYEEEKKMKAEEAKKA---EEAKIKAEELKKAEEE-------KKKVEQLKKKEAEEKKKAEELKkAEEEN 1659

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1705 SMRRRQTALKAAQQHWRHELA---------SAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSA----MRKGHNLLKKK 1771
Cdd:PTZ00121  1660 KIKAAEEAKKAEEDKKKAEEAkkaeedekkAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeenKIKAEEAKKEA 1739

                          730
                   ....*....|....
gi 1034572500 1772 EEKLNQLESSLWEE 1785
Cdd:PTZ00121  1740 EEDKKKAEEAKKDE 1753
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1178-1786 5.47e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 81.17  E-value: 5.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1178 EEAVAQVLEQDQRHLLESKQEKMQQLREKLCQeeeeeILRLHQQKEQSLSSLRERLQKAieeeeaRMREEESQRLSWLRA 1257
Cdd:TIGR00618  199 LTLRSQLLTLCTPCMPDTYHERKQVLEKELKH-----LREALQQTQQSHAYLTQKREAQ------EEQLKKQQLLKQLRA 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1258 QVQSSTQadedqiraeQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALnaakEKALQQLREQL 1337
Cdd:TIGR00618  268 RIEELRA---------QEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSR----AKLLMKRAAHV 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1338 egerkeavatlekEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSL 1417
Cdd:TIGR00618  335 -------------KQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKE 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1418 lrekrqevegeherrLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRR 1497
Cdd:TIGR00618  402 ---------------LDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQ 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1498 RHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLL--DVQRQVALKSEEATATHQQLEEaqkEHTHLLQS 1575
Cdd:TIGR00618  467 SLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIhpNPARQDIDNPGPLTRRMQRGEQ---TYAQLETS 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1576 NQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREV---TVEENNASPHFEPDLHIEDLRKSL 1652
Cdd:TIGR00618  544 EEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLqdlTEKLSEAEDMLACEQHALLRKLQP 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1653 GTNQtKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGV--ALRSAKEFlvqQTRSMRRRQTALKAAQQ------HWRHEL 1724
Cdd:TIGR00618  624 EQDL-QDVRLHLQQCSQELALKLTALHALQLTLTQERVreHALSIRVL---PKELLASRQLALQKMQSekeqltYWKEML 699

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034572500 1725 ASAQEvakdppgikALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEA 1786
Cdd:TIGR00618  700 AQCQT---------LLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQA 752
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1172-1597 6.89e-15

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 80.85  E-value: 6.89e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1172 AALKAMEEAVAQVLEQDQRhlLESKQEKMQQLREKLcqeeeEEILRLHQQKEQSLSSLR---ERLQKAIEEEEARMREEe 1248
Cdd:PRK02224   206 ERLNGLESELAELDEEIER--YEEQREQARETRDEA-----DEVLEEHEERREELETLEaeiEDLRETIAETEREREEL- 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1249 SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKlREELESQQKAERASLEQKnRQMLEQLKEEIE---------- 1312
Cdd:PRK02224   278 AEEVRDLRERLEeleeerDDLLAEAGLDDADAEAVEAR-REELEDRDEELRDRLEEC-RVAAQAHNEEAEslredaddle 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1313 --ASEKSEQAAlnaAKEKALQQLREQLEgERKEAVATLEKE-----------------HSAELERLCSSLEAKHREV--- 1370
Cdd:PRK02224   356 erAEELREEAA---ELESELEEAREAVE-DRREEIEELEEEieelrerfgdapvdlgnAEDFLEELREERDELREREael 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1371 ---VSSLQKKIQEAQQKEEAQlqKC--LGQ-VEHRVH-----QKSYHVAGYEHELSSLlREKRQEVEGEHER-------- 1431
Cdd:PRK02224   432 eatLRTARERVEEAEALLEAG--KCpeCGQpVEGSPHvetieEDRERVEELEAELEDL-EEEVEEVEERLERaedlveae 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1432 -RLDKMKEEHQQVMAKAREQYE-AEERKQRAELLGHLTGELErlqrAHERELETVRQEQHKRLEDLRRRHREQERKLQDL 1509
Cdd:PRK02224   509 dRIERLEERREDLEELIAERREtIEEKRERAEELRERAAELE----AEAEEKREAAAEAEEEAEEAREEVAELNSKLAEL 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1510 ELDLEtRAKDVKARLALLEVQEETA-----RREKQQLLDVQRQVALKSE-------EATATHQQLEEAQKEHTHLLQSNQ 1577
Cdd:PRK02224   585 KERIE-SLERIRTLLAAIADAEDEIerlreKREALAELNDERRERLAEKrerkrelEAEFDEARIEEAREDKERAEEYLE 663

                          490       500
                   ....*....|....*....|
gi 1034572500 1578 QLREILDELQARKLKLESQV 1597
Cdd:PRK02224   664 QVEEKLDELREERDDLQAEI 683
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1273-1590 8.88e-15

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 80.17  E-value: 8.88e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1273 EQEASLQKLREELESQQKAERASLEQKNRQMLE-----QLKEEIEASEKSEQAALNAAKEKALQQLREQ-----LEGERK 1342
Cdd:pfam17380  288 QQQEKFEKMEQERLRQEKEEKAREVERRRKLEEaekarQAEMDRQAAIYAEQERMAMERERELERIRQEerkreLERIRQ 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1343 EAVAtLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQlqkclgqveHRVHQKSYHVAGYEHELSSLLREKR 1422
Cdd:pfam17380  368 EEIA-MEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQ---------RKIQQQKVEMEQIRAEQEEARQREV 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1423 QEVEGEHERRLDKMKEEH---QQVMAKAREQYEAEERKQRaellghltgELERLQRAHERELETVRQEQHKRLEDLRRRH 1499
Cdd:pfam17380  438 RRLEEERAREMERVRLEEqerQQQVERLRQQEEERKRKKL---------ELEKEKRDRKRAEEQRRKILEKELEERKQAM 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1500 REQERKLQDLELDLETRAKDVKARLALLEVQEEtarREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHthllqsnQQL 1579
Cdd:pfam17380  509 IEEERKRKLLEKEMEERQKAIYEEERRREAEEE---RRKQQEMEERRRIQEQMRKATEERSRLEAMERER-------EMM 578

                          330
                   ....*....|.
gi 1034572500 1580 REILDELQARK 1590
Cdd:pfam17380  579 RQIVESEKARA 589
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1267-1596 3.54e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.56  E-value: 3.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1267 EDQIRAEQE--ASLQKLREELESQQKaeraSLEQKNRQMlEQLKEeIEASEKSEQAALNAAKEKALQQLREQLEGERKEA 1344
Cdd:TIGR02168  178 ERKLERTREnlDRLEDILNELERQLK----SLERQAEKA-ERYKE-LKAELRELELALLVLRLEELREELEELQEELKEA 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1345 VaTLEKEHSAELERLCSSLEAkHREVVSSLQKKIQEAQQKEEA---QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREK 1421
Cdd:TIGR02168  252 E-EELEELTAELQELEEKLEE-LRLEVSELEEEIEELQKELYAlanEISRLEQQKQILRERLANLERQLEELEAQLEELE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1422 RQEVE-GEHERRLDKMKEEHQQVMAKAREQYEAEERKQRaellghltgELERLQRAHERELETVRQEQH---KRLEDLRR 1497
Cdd:TIGR02168  330 SKLDElAEELAELEEKLEELKEELESLEAELEELEAELE---------ELESRLEELEEQLETLRSKVAqleLQIASLNN 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1498 RHREQERKLQDLEldlETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATH-QQLEEAQKEHTHLLQSN 1576
Cdd:TIGR02168  401 EIERLEARLERLE---DRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLeEALEELREELEEAEQAL 477

                          330       340
                   ....*....|....*....|
gi 1034572500 1577 QQLREILDELQARKLKLESQ 1596
Cdd:TIGR02168  478 DAAERELAQLQARLDSLERL 497
PTZ00121 PTZ00121
MAEBL; Provisional
 1060-1543 5.46e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 78.26  E-value: 5.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1060 EERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAE 1139
Cdd:PTZ00121  1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1140 DPEEkvavspTPPVSPEVRSTEPVappEQLSEAALKAmEEAVAQVLEQDQRHLLESKQE---KMQQLREKLCQEEEEEIL 1216
Cdd:PTZ00121  1419 KADE------AKKKAEEKKKADEA---KKKAEEAKKA-DEAKKKAEEAKKAEEAKKKAEeakKADEAKKKAEEAKKADEA 1488

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1217 RLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRaQVQSSTQADEDQiRAEQEASLQKLR--EEL---ESQQKA 1291
Cdd:PTZ00121  1489 KKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAK-KAEEAKKADEAK-KAEEKKKADELKkaEELkkaEEKKKA 1566

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1292 ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKeavatlEKEHSAELERlcsslEAKHREVV 1371
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE------AKIKAEELKK-----AEEEKKKV 1635

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1372 SSLQKKIQEAQQKEEaQLQKclgqvehrvhqksyhvagyEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQY 1451
Cdd:PTZ00121  1636 EQLKKKEAEEKKKAE-ELKK-------------------AEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALK 1695

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1452 EAEERKQRAEllghltgELERLQRAHERELETVRQEQHKR---LEDLRRRHREQERKLQDLELDlETRAKDVKARLALLE 1528
Cdd:PTZ00121  1696 KEAEEAKKAE-------ELKKKEAEEKKKAEELKKAEEENkikAEEAKKEAEEDKKKAEEAKKD-EEEKKKIAHLKKEEE 1767

                          490
                   ....*....|....*
gi 1034572500 1529 VQEETARREKQQLLD 1543
Cdd:PTZ00121  1768 KKAEEIRKEKEAVIE 1782
PTZ00121 PTZ00121
MAEBL; Provisional
 1119-1785 8.89e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 77.49  E-value: 8.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1119 EKGKEQHSQAEELGPGQEEAEDPEEKVAvsptppvSPEVRSTEPVAPPEQLSEAalkamEEAvaQVLEQDQRHLLESKQE 1198
Cdd:PTZ00121  1096 AFGKAEEAKKTETGKAEEARKAEEAKKK-------AEDARKAEEARKAEDARKA-----EEA--RKAEDAKRVEIARKAE 1161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1199 KMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAqvqsstqadEDQIRAEQEASL 1278
Cdd:PTZ00121  1162 DARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKA---------EDAKKAEAVKKA 1232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1279 QKLREELESQQKAEraslEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGER-KEAVATLEKEHSAELE 1357
Cdd:PTZ00121  1233 EEAKKDAEEAKKAE----EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKaDEAKKAEEKKKADEAK 1308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1358 RlcsslEAKHREVVSSLQKKIQEAQQKEEAQLQKClgqvehRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMK 1437
Cdd:PTZ00121  1309 K-----KAEEAKKADEAKKKAEEAKKKADAAKKKA------EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAK 1377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1438 EEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 1517
Cdd:PTZ00121  1378 KKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAK 1457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1518 KDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHthllQSNQQLREILDELQARKLKLESQV 1597
Cdd:PTZ00121  1458 KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAK----KKADEAKKAEEAKKADEAKKAEEA 1533

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1598 DLLQAQSQQLQKHfsslEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKslgtnqtkevSSSLSQSKEDLYLDSLS 1677
Cdd:PTZ00121  1534 KKADEAKKAEEKK----KADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK----------AEEAKKAEEARIEEVMK 1599

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1678 SHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAK--DPPGIKALEDMRKNlEKETRHLD 1755
Cdd:PTZ00121  1600 LYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKaeEENKIKAAEEAKKA-EEDKKKAE 1678

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1034572500 1756 EMKSA---MRKGHNLLKKKEE---KLNQLESSLWEE 1785
Cdd:PTZ00121  1679 EAKKAeedEKKAAEALKKEAEeakKAEELKKKEAEE 1714
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1174-1671 1.10e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 76.88  E-value: 1.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1174 LKAMEEAVAQVLEQdQRHL--LESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKaieeeearmreeesqr 1251
Cdd:COG4913    237 LERAHEALEDAREQ-IELLepIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEE---------------- 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1252 lswLRAQVQSsTQADEDQIRAEQEASLQKLREelesqqkAERASLEQKNRQmLEQLKEEIEASEKSEQAALNAAK--EKA 1329
Cdd:COG4913    300 ---LRAELAR-LEAELERLEARLDALREELDE-------LEAQIRGNGGDR-LEQLEREIERLERELEERERRRArlEAL 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1330 LQQLREQLEGERkEAVATLEKEHSAELERLcSSLEAKHREVVSSLQKKIQEAQqKEEAQLQKCLGQVEHRVHQKSYHVAG 1409
Cdd:COG4913    368 LAALGLPLPASA-EEFAALRAEAAALLEAL-EEELEALEEALAEAEAALRDLR-RELRELEAEIASLERRKSNIPARLLA 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1410 YEHELSSLLREKRQE---------------------------------VEGEHERR----LDKMKEEHQQVMAKAREQYE 1452
Cdd:COG4913    445 LRDALAEALGLDEAElpfvgelievrpeeerwrgaiervlggfaltllVPPEHYAAalrwVNRLHLRGRLVYERVRTGLP 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1453 AEERKQRAEllGHLTGELE------------RLQR-------AHERELETVRQ---------EQHKRLE-DLRRRHREQ- 1502
Cdd:COG4913    525 DPERPRLDP--DSLAGKLDfkphpfrawleaELGRrfdyvcvDSPEELRRHPRaitragqvkGNGTRHEkDDRRRIRSRy 602

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1503 ------ERKLQDLELD---LETRAKDVKARLALLEVQEETARREKQQLLDVQrQVALKSEEATATHQQLEEAQKEHTHLL 1573
Cdd:COG4913    603 vlgfdnRAKLAALEAElaeLEEELAEAEERLEALEAELDALQERREALQRLA-EYSWDEIDVASAEREIAELEAELERLD 681

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1574 QSN---QQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVtveENNASPHFEPDLhIEDLRK 1650
Cdd:COG4913    682 ASSddlAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAA---EDLARLELRALL-EERFAA 757

                          570       580
                   ....*....|....*....|.
gi 1034572500 1651 SLGTNQTKEVSSSLSQSKEDL 1671
Cdd:COG4913    758 ALGDAVERELRENLEERIDAL 778
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1103-1628 1.78e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 76.25  E-value: 1.78e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1103 QLSLQREQAPSppAACEKGKEQHSQAEELGPGQEEAEDPEEKVAvsptppvspEVRSTEPVAppEQLSEAALKAMEE--- 1179
Cdd:TIGR02168  320 ELEAQLEELES--KLDELAEELAELEEKLEELKEELESLEAELE---------ELEAELEEL--ESRLEELEEQLETlrs 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1180 AVAQVLEQ-----DQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEEsQRLSW 1254
Cdd:TIGR02168  387 KVAQLELQiaslnNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLE-EALEE 465

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1255 LRAQVQSSTQA------DEDQIRAEQeASLQKLREELESQQKAERASLEQKNR--QMLEQLKEEIEASEKSEqAALNAAK 1326
Cdd:TIGR02168  466 LREELEEAEQAldaaerELAQLQARL-DSLERLQENLEGFSEGVKALLKNQSGlsGILGVLSELISVDEGYE-AAIEAAL 543

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1327 EKALQQLREQLEGERKEAVATLEKEHS-----AELERLC-SSLEAKHRE------------------------------- 1369
Cdd:TIGR02168  544 GGRLQAVVVENLNAAKKAIAFLKQNELgrvtfLPLDSIKgTEIQGNDREilkniegflgvakdlvkfdpklrkalsyllg 623

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1370 ---VVSSLQ------KKIQE------------------------------AQQKEEAQLQKCLGQVEHRVHQKSYHVAGY 1410
Cdd:TIGR02168  624 gvlVVDDLDnalelaKKLRPgyrivtldgdlvrpggvitggsaktnssilERRREIEELEEKIEELEEKIAELEKALAEL 703

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1411 EHELSSLLREKRQevegeherrLDKMKEEHQQVMAKAREQYEAEERKQRAellghLTGELERLQRAHErELETVRQEQHK 1490
Cdd:TIGR02168  704 RKELEELEEELEQ---------LRKELEELSRQISALRKDLARLEAEVEQ-----LEERIAQLSKELT-ELEAEIEELEE 768

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1491 RLEDLRRRHREQERKLQDLELDLETRAKDVKA-RLALLEVQEEtARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEH 1569
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEELKAlREALDELRAE-LTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572500 1570 THLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREV 1628
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1178-1589 3.65e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.48  E-value: 3.65e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1178 EEAVAQVLEQDQRHL-LESKQEKMQQLREKLcQEEEEEILRLHQQKEQSLSSLRERLQkaieeeearmreEESQRLSWLR 1256
Cdd:TIGR02168  666 AKTNSSILERRREIEeLEEKIEELEEKIAEL-EKALAELRKELEELEEELEQLRKELE------------ELSRQISALR 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1257 AQVQSSTQadEDQIRAEQEASLQKLREELEsQQKAERASLEQKNRQMLEQLKEEIEasekSEQAALNAAKEkALQQLREQ 1336
Cdd:TIGR02168  733 KDLARLEA--EVEQLEERIAQLSKELTELE-AEIEELEERLEEAEEELAEAEAEIE----ELEAQIEQLKE-ELKALREA 804

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1337 LEGERKEavATLEKEHSAELERLCSSLEAKHREVVSSLQkkiQEAQQKEEAQLQkclgqvehrvhqksyhVAGYEHELSS 1416
Cdd:TIGR02168  805 LDELRAE--LTLLNEEAANLRERLESLERRIAATERRLE---DLEEQIEELSED----------------IESLAAEIEE 863

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1417 lLREKRQEVEGEHErRLDKMKEEHQQVMAKAREQYEAEERKQRaellghltgELERLQRAHERELETVRQEQHK---RLE 1493
Cdd:TIGR02168  864 -LEELIEELESELE-ALLNERASLEEALALLRSELEELSEELR---------ELESKRSELRRELEELREKLAQlelRLE 932

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1494 DLR-RRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRqVALKS-EEATATHQQLEEAQKEHTH 1571
Cdd:TIGR02168  933 GLEvRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGP-VNLAAiEEYEELKERYDFLTAQKED 1011

                          410
                   ....*....|....*...
gi 1034572500 1572 LLQSNQQLREILDELQAR 1589
Cdd:TIGR02168 1012 LTEAKETLEEAIEEIDRE 1029
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1166-1586 2.06e-12

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 72.69  E-value: 2.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1166 PEQLSEAALKAMEEAVAQVLEQDQRHLLESKQ---EKMQQL--------REKLCQEEEEEILRLHQQKEQSL-SSLRERL 1233
Cdd:TIGR00618  435 LQQRYAELCAAAITCTAQCEKLEKIHLQESAQslkEREQQLqtkeqihlQETRKKAVVLARLLELQEEPCPLcGSCIHPN 514

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1234 QKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEaSLQKLREELESQQKAERASLEQKNR--QMLEQLKEEI 1311
Cdd:TIGR00618  515 PARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERK-QRASLKEQMQEIQQSFSILTQCDNRskEDIPNLQNIT 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1312 EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEA-----QQKEE 1386
Cdd:TIGR00618  594 VRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHalsirVLPKE 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1387 --AQLQKCLGQVEHRVHQKSYHVAGYEHELSsLLREkrqevEGEHERRLDKMKEEHQQVMAKAREQYEAEE--------- 1455
Cdd:TIGR00618  674 llASRQLALQKMQSEKEQLTYWKEMLAQCQT-LLRE-----LETHIEEYDREFNEIENASSSLGSDLAAREdalnqslke 747

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1456 -RKQRAELLGHLTGELERLQRAHERELETVRQEQHKRlEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETA 1534
Cdd:TIGR00618  748 lMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLA-AEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETL 826

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034572500 1535 RREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDEL 1586
Cdd:TIGR00618  827 VQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKL 878
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1171-1586 3.55e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 71.72  E-value: 3.55e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVLE-QDQRHLLESKQEKMQQLREKLCQEEEE-EILRLHQQKEQSLSSLRERLQkaieeeearmreEE 1248
Cdd:COG4717     77 EEELKEAEEKEEEYAElQEELEELEEELEELEAELEELREELEKlEKLLQLLPLYQELEALEAELA------------EL 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1249 SQRLSWLRAQVQSSTQADEDQIRAEQEasLQKLREELESQQKAERASLEQKNRQMLEQLkEEIEASEKSEQAALNAAKEK 1328
Cdd:COG4717    145 PERLEELEERLEELRELEEELEELEAE--LAELQEELEELLEQLSLATEEELQDLAEEL-EELQQRLAELEEELEEAQEE 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1329 aLQQLREQLEGERKEAVATLEKEHSAELERL----------------------------CSSLEAKHREVVSSLQKKIQE 1380
Cdd:COG4717    222 -LEELEEELEQLENELEAAALEERLKEARLLlliaaallallglggsllsliltiagvlFLVLGLLALLFLLLAREKASL 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1381 AQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS------------SLLREKRQEVEGEHERRLDKMKEEHQQVMAKA- 1447
Cdd:COG4717    301 GKEAEELQALPALEELEEEELEELLAALGLPPDLSpeellelldrieELQELLREAEELEEELQLEELEQEIAALLAEAg 380

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1448 ----------------REQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLEL 1511
Cdd:COG4717    381 vedeeelraaleqaeeYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEA 460

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572500 1512 DLETRAKDvkARLALLEVQEETARREKQQLldVQRQVALKseeatATHQQLEEAQKEHTHLLQS--NQQLREILDEL 1586
Cdd:COG4717    461 ELEQLEED--GELAELLQELEELKAELREL--AEEWAALK-----LALELLEEAREEYREERLPpvLERASEYFSRL 528
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1171-1544 4.05e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 72.01  E-value: 4.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVleQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQsLSSLRERLQKAieeeearmreeeSQ 1250
Cdd:TIGR02168  683 EEKIEELEEKIAEL--EKALAELRKELEELEEELEQLRKELEELSRQISALRKD-LARLEAEVEQL------------EE 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 RLSWLRAQVQSSTQADEDQIRAEQEASLQKLREElesqqkAERASLEQKNRQMLEQLKEEIEASeKSEQAALNAAKEKAl 1330
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAE------AEIEELEAQIEQLKEELKALREAL-DELRAELTLLNEEA- 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1331 QQLREQLEGERKEAVATlekehSAELERLCSSLEAKhREVVSSLQKKIQEAQQKEEAQlqkclgQVEHRVHQKSYHVAGY 1410
Cdd:TIGR02168  820 ANLRERLESLERRIAAT-----ERRLEDLEEQIEEL-SEDIESLAAEIEELEELIEEL------ESELEALLNERASLEE 887

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1411 EHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKareQYEAEERKQRAELLghLTGELERLQRAHERELETVRQEQHK 1490
Cdd:TIGR02168  888 ALALLRSELEELSEELRELESKRSELRRELEELREK---LAQLELRLEGLEVR--IDNLQERLSEEYSLTLEEAEALENK 962

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1491 RLED---LRRRHREQERKLQDL---ELDLETRAKDVKARLALLEVQEETARREKQQLLDV 1544
Cdd:TIGR02168  963 IEDDeeeARRRLKRLENKIKELgpvNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEEA 1022
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1193-1781 6.65e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 71.30  E-value: 6.65e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1193 LESKQEKMQQLREKLCQeeeeeilrLHQQKEQSLSSLRERLQKAIEEEEARMReeesqrlswLRAQVQSSTQADEDQIRA 1272
Cdd:pfam15921  115 LQTKLQEMQMERDAMAD--------IRRRESQSQEDLRNQLQNTVHELEAAKC---------LKEDMLEDSNTQIEQLRK 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1273 ---EQEASLQKLR------EELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLrEQLEGERKE 1343
Cdd:pfam15921  178 mmlSHEGVLQEIRsilvdfEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQL-EALKSESQN 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1344 AVATLEKEHSAELERLCSSLE----------AKHREVVSSLQKK---IQEAQQKEEAQLQKCLGQVEHRVHQksyhvagy 1410
Cdd:pfam15921  257 KIELLLQQHQDRIEQLISEHEveitgltekaSSARSQANSIQSQleiIQEQARNQNSMYMRQLSDLESTVSQ-------- 328

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1411 eheLSSLLREKRQEVEgeherrlDKMKEEHQQVMAKAREQYEAE-ERKQRAELLGHLTGELERL-QRAHERELE-TVRQE 1487
Cdd:pfam15921  329 ---LRSELREAKRMYE-------DKIEELEKQLVLANSELTEARtERDQFSQESGNLDDQLQKLlADLHKREKElSLEKE 398

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1488 QHKRLEDlrrRHREQERKLQDLELDLETRAKDVKARLALLE-VQEETARREKQQLLDVQrqvalkseeatATHQQLEEAQ 1566
Cdd:pfam15921  399 QNKRLWD---RDTGNSITIDHLRRELDDRNMEVQRLEALLKaMKSECQGQMERQMAAIQ-----------GKNESLEKVS 464

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1567 KEHTHLLQSNQQLREILDELQARKLKLESqvdllqaqsqqLQKHFSSLEAEAQKKQHLLR----EVTVEENNASPHFEPD 1642
Cdd:pfam15921  465 SLTAQLESTKEMLRKVVEELTAKKMTLES-----------SERTVSDLTASLQEKERAIEatnaEITKLRSRVDLKLQEL 533

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1643 LHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSH--NVWHLLSAEGvalRSAKEFLVQQTRsmrrrqtaLKAAQQHW 1720
Cdd:pfam15921  534 QHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQieNMTQLVGQHG---RTAGAMQVEKAQ--------LEKEINDR 602

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1721 RHELASAQEVA-KDPPGIKALEDMRKNLEKETRHLDEMKSA-MRKGHNLLKKKEEKLNQLESS 1781
Cdd:pfam15921  603 RLELQEFKILKdKKDAKIRELEARVSDLELEKVKLVNAGSErLRAVKDIKQERDQLLNEVKTS 665
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1119-1510 7.42e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 70.84  E-value: 7.42e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1119 EKGKEQHSQAEELGpgqEEAEDPEEKVavsptppvspEVRSTEPVAPPEQLsEAALKAMEEAVAQVLEQDQRhlLESKQE 1198
Cdd:PRK02224   356 ERAEELREEAAELE---SELEEAREAV----------EDRREEIEELEEEI-EELRERFGDAPVDLGNAEDF--LEELRE 419

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1199 KMQQLREKLCQEeeeeilrlhqqkEQSLSSLRERLQKAIEEEEARMREEESQrlswlraQVQSSTQADEDQIRAEQEASL 1278
Cdd:PRK02224   420 ERDELREREAEL------------EATLRTARERVEEAEALLEAGKCPECGQ-------PVEGSPHVETIEEDRERVEEL 480

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1279 QKLREELESQQ-----KAERASLEQKNRQMLEQLKEEIEASEK--SEQAALNAAKEKALQQLREQLEGERKEAVATLEKE 1351
Cdd:PRK02224   481 EAELEDLEEEVeeveeRLERAEDLVEAEDRIERLEERREDLEEliAERRETIEEKRERAEELRERAAELEAEAEEKREAA 560

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1352 HSAELErlcsslEAKHREVVSSLQKKIQEAQQKEEAqlqkcLGQVEHRVHQksyhVAGYEHELSSLlREKR---QEVEGE 1428
Cdd:PRK02224   561 AEAEEE------AEEAREEVAELNSKLAELKERIES-----LERIRTLLAA----IADAEDEIERL-REKRealAELNDE 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1429 HERRLDKMKEEHQQVMAKAREQY--EAEERKQRAE-LLGHLTGELERLqRAHERELET----VRQEQhKRLEDLRRRHRE 1501
Cdd:PRK02224   625 RRERLAEKRERKRELEAEFDEARieEAREDKERAEeYLEQVEEKLDEL-REERDDLQAeigaVENEL-EELEELRERREA 702


                   ....*....
gi 1034572500 1502 QERKLQDLE 1510
Cdd:PRK02224   703 LENRVEALE 711
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1193-1597 1.02e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 70.18  E-value: 1.02e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1193 LESKQEKMQQLREKLcqeeeeeilRLHQQKEQSLSSLRERLQKAieeeeARMREEESQRLSWLRAQVQsstQADEDQIRA 1272
Cdd:COG4717     73 LKELEEELKEAEEKE---------EEYAELQEELEELEEELEEL-----EAELEELREELEKLEKLLQ---LLPLYQELE 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1273 EQEASLQKLREELES--QQKAERASLEQKNRQMLEQLkEEIEASEKSEQAALNAAKEKALQQLREQLEgERKEAVATLEK 1350
Cdd:COG4717    136 ALEAELAELPERLEEleERLEELRELEEELEELEAEL-AELQEELEELLEQLSLATEEELQDLAEELE-ELQQRLAELEE 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1351 EhSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQV------EHRVHQKSYHVAGYEHELSSLLREKRQE 1424
Cdd:COG4717    214 E-LEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALlallglGGSLLSLILTIAGVLFLVLGLLALLFLL 292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1425 VEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQER 1504
Cdd:COG4717    293 LAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEI 372

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1505 KlqdlELDLETRAKDVKARLALLEvQEETARREKQQLLDVQRQVA--LKSEEATATHQQLEEAQKEHTHLLQSNQQLREI 1582
Cdd:COG4717    373 A----ALLAEAGVEDEEELRAALE-QAEEYQELKEELEELEEQLEelLGELEELLEALDEEELEEELEELEEELEELEEE 447

                          410
                   ....*....|....*
gi 1034572500 1583 LDELQARKLKLESQV 1597
Cdd:COG4717    448 LEELREELAELEAEL 462
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1167-1789 1.30e-11

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 70.39  E-value: 1.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQVLEQDQRHLLEsKQEKMQQLREKLCQ--EEEEEILRLHQQKEQsLSSLRERLQKAIEEEEARM 1244
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELK-LQELKLKEQAKKALeyYQLKEKLELEEEYLL-YLDYLKLNEERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1245 REEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQM------LEQLKEEIEASEKSE 1318
Cdd:pfam02463  247 RDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLerrkvdDEEKLKESEKEKKKA 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1319 QAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQkCLGQVEH 1398
Cdd:pfam02463  327 EKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE-LKSEEEK 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1399 RVHQKSYHVAGYEHELSSLLREKRQEVEGEhERRLDKMKEEHQQVMAKAREQYEAEERKQRAEllghltgELERLQRAHE 1478
Cdd:pfam02463  406 EAQLLLELARQLEDLLKEEKKEELEILEEE-EESIELKQGKLTEEKEELEKQELKLLKDELEL-------KKSEDLLKET 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1479 RELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALkSEEATAT 1558
Cdd:pfam02463  478 QLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAV-IVEVSAT 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1559 HQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKhfsSLEAEAQKKQHLLREVTVEEnNASPH 1638
Cdd:pfam02463  557 ADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQ---LDKATLEADEDDKRAKVVEG-ILKDT 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1639 FEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSshnvwhLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQ 1718
Cdd:pfam02463  633 ELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSEL------TKELLEIQELQEKAESELAKEEILRRQLEIKKKEQ 706

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572500 1719 HWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDE 1789
Cdd:pfam02463  707 REKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELA 777
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1167-1544 1.41e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.97  E-value: 1.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLcQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMRE 1246
Cdd:COG1196    446 EAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL-AEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAG 524

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1247 EESQRLSW---LRAQVQSSTQADEDQIRAEQEASLQKLREELEsQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALN 1323
Cdd:COG1196    525 AVAVLIGVeaaYEAALEAALAAALQNIVVEDDEVAAAAIEYLK-AAKAGRATFLPLDKIRARAALAAALARGAIGAAVDL 603

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1324 AAKEKALQQLREQLEGERkEAVATLEKEHSAELERLCSSLEAKHREVvSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 1403
Cdd:COG1196    604 VASDLREADARYYVLGDT-LLGRTLVAARLEAALRRAVTLAGRLREV-TLEGEGGSAGGSLTGGSRRELLAALLEAEAEL 681

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1404 SyhvagyehELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELET 1483
Cdd:COG1196    682 E--------ELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEAL 753

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034572500 1484 VRQEQHKRLEDLRRRHREQERKLQDLE---LDLETRAKDVKARLALLEVQEETARREKQQLLDV 1544
Cdd:COG1196    754 EELPEPPDLEELERELERLEREIEALGpvnLLAIEEYEELEERYDFLSEQREDLEEARETLEEA 817
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1314-1652 1.43e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.10  E-value: 1.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1314 SEKSEQAALNAAKEKA-LQQLREQLEGERKEAVATLEKEHSAELER--LCSSLEAKHREVvSSLQKKIQEAQQKEEAQLQ 1390
Cdd:TIGR02169  659 SRAPRGGILFSRSEPAeLQRLRERLEGLKRELSSLQSELRRIENRLdeLSQELSDASRKI-GEIEKEIEQLEQEEEKLKE 737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1391 KcLGQVEHRVHQKSyhvagyehelssllrEKRQEVEGEHERrLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGEL 1470
Cdd:TIGR02169  738 R-LEELEEDLSSLE---------------QEIENVKSELKE-LEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAEL 800

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1471 erlqraheRELETVRQEQHKRLEDLrrrhreqERKLQDLELDLEtrakdvkarLALLEVQEETARRE--KQQLLDVQRQV 1548
Cdd:TIGR02169  801 --------SKLEEEVSRIEARLREI-------EQKLNRLTLEKE---------YLEKEIQELQEQRIdlKEQIKSIEKEI 856

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1549 ALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREV 1628
Cdd:TIGR02169  857 ENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEI 936

                          330       340
                   ....*....|....*....|....
gi 1034572500 1629 TVEENNASPHFEPDLHIEDLRKSL 1652
Cdd:TIGR02169  937 EDPKGEDEEIPEEELSLEDVQAEL 960
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1427-1795 2.47e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.32  E-value: 2.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1427 GEHERRLDKMKEEHQQVMaKAREQYEAEERKQRAELLGHLT---GELERLQRAHER------ELETVRQEQHKRLEDLRR 1497
Cdd:TIGR02168  196 NELERQLKSLERQAEKAE-RYKELKAELRELELALLVLRLEelrEELEELQEELKEaeeeleELTAELQELEEKLEELRL 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1498 RHREQERKLQDLEldleTRAKDVKARLALLEVQEETARREKQQLldvQRQVALKSEEATATHQQLEEAQKEHThllqsnq 1577
Cdd:TIGR02168  275 EVSELEEEIEELQ----KELYALANEISRLEQQKQILRERLANL---ERQLEELEAQLEELESKLDELAEELA------- 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1578 QLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEP-DLHIEDLRKSLgtNQ 1656
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlEARLERLEDRR--ER 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1657 TKEVSSSLSQSKEDLYLDSLSSHNVwhLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEvakdppG 1736
Cdd:TIGR02168  419 LQQEIEELLKKLEEAELKELQAELE--ELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQA------R 490

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572500 1737 IKALEDMRKNLEKETRhldemksamrkGHNLLKKKEEKLNQLESSLWE--------EASDEGTLGGS 1795
Cdd:TIGR02168  491 LDSLERLQENLEGFSE-----------GVKALLKNQSGLSGILGVLSElisvdegyEAAIEAALGGR 546
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1288-1596 2.49e-11

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 67.25  E-value: 2.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1288 QQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEgerkeavatlEKEHSAELERLcssLEAKH 1367
Cdd:pfam13868   33 RIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIE----------EREQKRQEEYE---EKLQE 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1368 REVVSSLQKKIQEAQQKEEAQLQKclgqvehRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKA 1447
Cdd:pfam13868  100 REQMDEIVERIQEEDQAEAEEKLE-------KQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKEKAEREEERE 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1448 REQYEAEERKQR-AELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDlETRAKDVKARLAL 1526
Cdd:pfam13868  173 AEREEIEEEKEReIARLRAQQEKAQDEKAERDELRAKLYQEEQERKERQKEREEAEKKARQRQELQ-QAREEQIELKERR 251

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1527 LEVQEETARREKQQLLDVQR-QVALKSEEATATHQQLEEAQKEHTHLLQSNQQLR--EILDELQARKLKLESQ 1596
Cdd:pfam13868  252 LAEEAEREEEEFERMLRKQAeDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQRaaEREEELEEGERLREEE 324
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1261-1779 5.97e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 67.78  E-value: 5.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1261 SSTQADEDQIRAEQEASLQKLRE--ELESQQKAERASLE--QKNRQMLEQLKEEIEASEKSEQAALNAAK--EKALQQLR 1334
Cdd:PRK03918   186 KRTENIEELIKEKEKELEEVLREinEISSELPELREELEklEKEVKELEELKEEIEELEKELESLEGSKRklEEKIRELE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1335 EQLEGERKE-------------------AVATLEKEHSAELERL--CSSLEAKHREVVSSLQKKIQEAQQKEE--AQLQK 1391
Cdd:PRK03918   266 ERIEELKKEieeleekvkelkelkekaeEYIKLSEFYEEYLDELreIEKRLSRLEEEINGIEERIKELEEKEErlEELKK 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1392 CLGQVEHRVHQKSYHVAGYEhELSSLLREKRQEVEGEHERRLDKMKEEHQQVmAKAREQYEAEERKQRAELlGHLTGELE 1471
Cdd:PRK03918   346 KLKELEKRLEELEERHELYE-EAKAKKEELERLKKRLTGLTPEKLEKELEEL-EKAKEEIEEEISKITARI-GELKKEIK 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1472 RLQRAHErELETVRQ---------EQHKRLEDLRRRHREQERKLQDLElDLETRAKDVKARLALLEVQeetarREKQQLL 1542
Cdd:PRK03918   423 ELKKAIE-ELKKAKGkcpvcgrelTEEHRKELLEEYTAELKRIEKELK-EIEEKERKLRKELRELEKV-----LKKESEL 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1543 DVQRQVA--LKSEEATATHQQLEEAQKEHTHLlqsnQQLREILDELQARKLKLESQVdllqaqsqqlqkhfSSLEAEAQK 1620
Cdd:PRK03918   496 IKLKELAeqLKELEEKLKKYNLEELEKKAEEY----EKLKEKLIKLKGEIKSLKKEL--------------EKLEELKKK 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1621 KQHLLREV-TVEENNASphfepdlhIEDLRKSLGTNQTKEVSSSLsQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFL 1699
Cdd:PRK03918   558 LAELEKKLdELEEELAE--------LLKELEELGFESVEELEERL-KELEPFYNEYLELKDAEKELEREEKELKKLEEEL 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1700 VQ----------QTRSMRRRQTALKAAQQHWRHE------LASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRK 1763
Cdd:PRK03918   629 DKafeelaetekRLEELRKELEELEKKYSEEEYEelreeyLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREK 708

                          570
                   ....*....|....*.
gi 1034572500 1764 GHNLLKKKEEKLNQLE 1779
Cdd:PRK03918   709 AKKELEKLEKALERVE 724
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1182-1524 9.27e-11

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 65.71  E-value: 9.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1182 AQVLEQDQRHLLESKQEK-----MQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLR 1256
Cdd:pfam13868   26 AQIAEKKRIKAEEKEEERrldemMEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1257 AQVQssTQADEDQIRAEQEASLQKLREELEsQQKAERASLEQKNRQMLEQL----------KEEIEASEKSEQAALNAAK 1326
Cdd:pfam13868  106 IVER--IQEEDQAEAEEKLEKQRQLREEID-EFNEEQAEWKELEKEEEREEderileylkeKAEREEEREAEREEIEEEK 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1327 EKALQQLREQLEGERKeavatlEKEHSAEL--ERLCSSLEAKHRevvsslQKKIQEAQQKEEAQLQKCLGQVEHRVHqks 1404
Cdd:pfam13868  183 EREIARLRAQQEKAQD------EKAERDELraKLYQEEQERKER------QKEREEAEKKARQRQELQQAREEQIEL--- 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1405 yhvagyehelssllREKRQEVEGEHERRLDKMKEEHQQVMAKaREQYEAEERKQRaellghltgelerlQRAHERELETV 1484
Cdd:pfam13868  248 --------------KERRLAEEAEREEEEFERMLRKQAEDEE-IEQEEAEKRRMK--------------RLEHRRELEKQ 298

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1034572500 1485 RQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARL 1524
Cdd:pfam13868  299 IEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKK 338
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1215-1786 2.00e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 66.53  E-value: 2.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1215 ILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERA 1294
Cdd:pfam02463  164 GSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQ 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1295 SLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQlreQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSL 1374
Cdd:pfam02463  244 ELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEK---KLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1375 QKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYE-A 1453
Cdd:pfam02463  321 KEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELElK 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1454 EERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEET 1533
Cdd:pfam02463  401 SEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLV 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1534 ARREKQQLLDvqrqvaLKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSS 1613
Cdd:pfam02463  481 KLQEQLELLL------SRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVS 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1614 -LEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTnqtkevssslsqsKEDLYLDSLSSHNVWHLLSAEGVAL 1692
Cdd:pfam02463  555 aTADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAV-------------LEIDPILNLAQLDKATLEADEDDKR 621

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1693 RSAKEFLVQQTRSMRRRQTALKAAQ--QHWRHELASAQEVAKDPPGIKALEDMRKN--LEKETRHLDEMKSAMRKGHNLL 1768
Cdd:pfam02463  622 AKVVEGILKDTELTKLKESAKAKESglRKGVSLEEGLAEKSEVKASLSELTKELLEiqELQEKAESELAKEEILRRQLEI 701

                          570
                   ....*....|....*...
gi 1034572500 1769 KKKEEKLNQLESSLWEEA 1786
Cdd:pfam02463  702 KKKEQREKEELKKLKLEA 719
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1168-1543 2.40e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 66.24  E-value: 2.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1168 QLSEAALKAMEEAVAQVLE--QDQRHLLESKQEKMQQLREKLCQEeeeeiLRLHQQKEQSLSSLRERLQKaieeeearMR 1245
Cdd:TIGR02169  666 ILFSRSEPAELQRLRERLEglKRELSSLQSELRRIENRLDELSQE-----LSDASRKIGEIEKEIEQLEQ--------EE 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1246 EEESQRLSWLRAQVQSSTQADEDQIR---------AEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIeaSEK 1316
Cdd:TIGR02169  733 EKLKERLEELEEDLSSLEQEIENVKSelkeleariEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEV--SRI 810

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1317 SEQAALNAAKEKALQQLREQLEGERKEAVATLEkehsaelerlcssleakhrevvsSLQKKIQEAQQKEEAqLQKCLGQV 1396
Cdd:TIGR02169  811 EARLREIEQKLNRLTLEKEYLEKEIQELQEQRI-----------------------DLKEQIKSIEKEIEN-LNGKKEEL 866

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1397 EHRVHQKSYHVAGYEHELSSLLREKRqevegEHERRLDKMKEEHQQvmAKAREQYEAEERKQRAELLGHLTGELERLQRA 1476
Cdd:TIGR02169  867 EEELEELEAALRDLESRLGDLKKERD-----ELEAQLRELERKIEE--LEAQIEKKRKRLSELKAKLEALEEELSEIEDP 939

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572500 1477 HERELETVRQEQhkRLEDLRRRHREQERKLQDLElDLETRA----KDVKARLALLEVQEETARREKQQLLD 1543
Cdd:TIGR02169  940 KGEDEEIPEEEL--SLEDVQAELQRVEEEIRALE-PVNMLAiqeyEEVLKRLDELKEKRAKLEEERKAILE 1007
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1179-1554 1.71e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 63.20  E-value: 1.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1179 EAVAQVLEQDQRHLLESKQekMQQLREKLcqeeeeeilrlhQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQ 1258
Cdd:pfam05483  408 EELKKILAEDEKLLDEKKQ--FEKIAEEL------------KGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEV 473

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1259 VQSSTQADEDQIR-AEQEASLQKLR-EELESQQKAERASLEQKNRQ------------MLEQLkEEIEASEKSEQAALNA 1324
Cdd:pfam05483  474 EDLKTELEKEKLKnIELTAHCDKLLlENKELTQEASDMTLELKKHQediinckkqeerMLKQI-ENLEEKEMNLRDELES 552

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1325 AKEKALQQ-------LREQLEGERKEAVATLEKEHSAE-LERLCSSLeakhREVVSSLQKKIQEAQQKEEAQLQKC---- 1392
Cdd:pfam05483  553 VREEFIQKgdevkckLDKSEENARSIEYEVLKKEKQMKiLENKCNNL----KKQIENKNKNIEELHQENKALKKKGsaen 628

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1393 --LGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGE---HERRLDKMKEEHQQVMAKAREQYEAEERKQraellgHLT 1467
Cdd:pfam05483  629 kqLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKkisEEKLLEEVEKAKAIADEAVKLQKEIDKRCQ------HKI 702

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1468 GELERLQRAHERELETVRQEQHKRLEDLRRRHREQerklQDLELDLETRAKDVKARLALLEVQEETARREKQQL-LDVQR 1546
Cdd:pfam05483  703 AEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQ----SSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLkMEAKE 778


                   ....*...
gi 1034572500 1547 QVALKSEE 1554
Cdd:pfam05483  779 NTAILKDK 786
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1254-1568 1.89e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 63.16  E-value: 1.89e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1254 WLRAQVQSSTQADEDQIRAeQEASLQKLREELESQQKAERASLEQKNrQMLEQLKEEIEASEKSEQAALnaaKEKALQQL 1333
Cdd:TIGR02169  226 YELLKEKEALERQKEAIER-QLASLEEELEKLTEEISELEKRLEEIE-QLLEELNKKIKDLGEEEQLRV---KEKIGELE 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1334 REQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEaQQKEEAQLQKCLGQVEHRVHQKSYHVAgyehE 1413
Cdd:TIGR02169  301 AEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEE-ERKRRDKLTEEYAELKEELEDLRAELE----E 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1414 LSSLLREKRQEVEgEHERRLDKMKEEHQQVMakaREQYEAEERKQRAEL-LGHLTGELERLQRAHeRELETvrqeqhkRL 1492
Cdd:TIGR02169  376 VDKEFAETRDELK-DYREKLEKLKREINELK---RELDRLQEELQRLSEeLADLNAAIAGIEAKI-NELEE-------EK 443

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1493 EDLRRRHREQERKLQDLELDLEtrakdvKARLALLEVQEETARREKQqlldvQRQVALKSEEATATHQQLEEAQKE 1568
Cdd:TIGR02169  444 EDKALEIKKQEWKLEQLAADLS------KYEQELYDLKEEYDRVEKE-----LSKLQRELAEAEAQARASEERVRG 508
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1171-1787 2.14e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 63.16  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVLEQ--DQRHLLESKQEKMQQLREKLCQEEEEEILRLhQQKEQSLSSLRERLQKAIEEEEarmreee 1248
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEisELEKRLEEIEQLLEELNKKIKDLGEEEQLRV-KEKIGELEAEIASLERSIAEKE------- 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1249 sQRLSWLRAQVQsstQADEDqiRAEQEASLQKLREELESQQKaERASLE---QKNRQMLEQLKEEIEASEKSEQAA---L 1322
Cdd:TIGR02169  315 -RELEDAEERLA---KLEAE--IDKLLAEIEELEREIEEERK-RRDKLTeeyAELKEELEDLRAELEEVDKEFAETrdeL 387

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1323 NAAKEK--ALQQLREQLEGERKEAVATLEKEHS--AELERLCSSLEAKHREVVS---SLQKKIQEAQQKEEaQLQKCLGQ 1395
Cdd:TIGR02169  388 KDYREKleKLKREINELKRELDRLQEELQRLSEelADLNAAIAGIEAKINELEEekeDKALEIKKQEWKLE-QLAADLSK 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1396 VEHRVHQKSYHVAGYEHELSSLLRE-------KRQEVEGEHERR-------------------LDKMKEEHQ---QVMAK 1446
Cdd:TIGR02169  467 YEQELYDLKEEYDRVEKELSKLQRElaeaeaqARASEERVRGGRaveevlkasiqgvhgtvaqLGSVGERYAtaiEVAAG 546

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1447 AREQY---EAEERKQRA-ELL-----GHLTGELERLQRAHERELETVRQ-----------EQHKRLE------------- 1493
Cdd:TIGR02169  547 NRLNNvvvEDDAVAKEAiELLkrrkaGRATFLPLNKMRDERRDLSILSEdgvigfavdlvEFDPKYEpafkyvfgdtlvv 626

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1494 ---DLRRRHREQERkLQDLELDL-----------------ETRAKDVKARLALLEVQEETARREKQQLLD----VQRQVA 1549
Cdd:TIGR02169  627 ediEAARRLMGKYR-MVTLEGELfeksgamtggsraprggILFSRSEPAELQRLRERLEGLKRELSSLQSelrrIENRLD 705

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1550 LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVt 1629
Cdd:TIGR02169  706 ELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDL- 784

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1630 veENNASPHFEPDL--HIEDLRKSLGTNQtkEVSSSLSQSKEDLYLDSLSshnvwhllsaegvaLRSAKEFLVQQTRSMR 1707
Cdd:TIGR02169  785 --EARLSHSRIPEIqaELSKLEEEVSRIE--ARLREIEQKLNRLTLEKEY--------------LEKEIQELQEQRIDLK 846

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1708 RRQTALKAAQQHWRHELAS-AQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEA 1786
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEElEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKL 926


                   .
gi 1034572500 1787 S 1787
Cdd:TIGR02169  927 E 927
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1174-1793 4.92e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 61.99  E-value: 4.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1174 LKAMEEAVAQVLE-QDQRHLLESKQEKMQQLREKLCQEEEE----------EILRLHQQKEQSLSSLRERLQKAIEEEEA 1242
Cdd:TIGR00606  254 LKEIEHNLSKIMKlDNEIKALKSRKKQMEKDNSELELKMEKvfqgtdeqlnDLYHNHQRTVREKERELVDCQRELEKLNK 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1243 RMREEESQRLSWLRAQVQSSTQAD--EDQIRAEQEASLQ-KLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQ 1319
Cdd:TIGR00606  334 ERRLLNQEKTELLVEQGRLQLQADrhQEHIRARDSLIQSlATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQL 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1320 AALNAAKEKALQQLREQLEGERKEAVATLEKEhSAELERLCSSLeakhREVVSSLQK---------KIQEAQQKEEAQLQ 1390
Cdd:TIGR00606  414 CADLQSKERLKQEQADEIRDEKKGLGRTIELK-KEILEKKQEEL----KFVIKELQQlegssdrilELDQELRKAERELS 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1391 KClgQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHErrLDKMKEEHQQVMAKAREQYEAEER------KQRAELLG 1464
Cdd:TIGR00606  489 KA--EKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQ--LNHHTTTRTQMEMLTKDKMDKDEQirkiksRHSDELTS 564

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1465 HL-----TGELERLQRAHERELETVR------QEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARlallEVQEET 1533
Cdd:TIGR00606  565 LLgyfpnKKQLEDWLHSKSKEINQTRdrlaklNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGS----QDEESD 640

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1534 ARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSS 1613
Cdd:TIGR00606  641 LERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKK 720

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1614 LEAEaqkKQHLLREVTVEENnasphfEPDLHIEDLRKSlgTNQTKEVSSSLSQSKEDLYLDSlsshnvwHLLSAEGVALR 1693
Cdd:TIGR00606  721 KEKR---RDEMLGLAPGRQS------IIDLKEKEIPEL--RNKLQKVNRDIQRLKNDIEEQE-------TLLGTIMPEEE 782

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1694 SAKEFLVQQTrSMRRRQTALKAAQQHWRHELASAQEVAKDppgiKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEE 1773
Cdd:TIGR00606  783 SAKVCLTDVT-IMERFQMELKDVERKIAQQAAKLQGSDLD----RTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQE 857

                          650       660
                   ....*....|....*....|
gi 1034572500 1774 KLNQLESSLWEEASDEGTLG 1793
Cdd:TIGR00606  858 QIQHLKSKTNELKSEKLQIG 877
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1060-1597 8.16e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.14  E-value: 8.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1060 EERAQSPPRSLAT-EEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQapsppaacekgKEQHSQAEELGPGQEEA 1138
Cdd:TIGR00618  211 PCMPDTYHERKQVlEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLL-----------KQLRARIEELRAQEAVL 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1139 EDPEEKVAVSP-TPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHL-----LESKQEKMQQL--------- 1203
Cdd:TIGR00618  280 EETQERINRARkAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVkqqssIEEQRRLLQTLhsqeihird 359

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1204 --------REKLCQEEEEE--ILRLHQQKE------QSLSSLRERLQK---------------AIEEEEARMREEESQRL 1252
Cdd:TIGR00618  360 ahevatsiREISCQQHTLTqhIHTLQQQKTtltqklQSLCKELDILQReqatidtrtsafrdlQGQLAHAKKQQELQQRY 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1253 SWLRAQVQSSTQADEDQIRAEQEASLQKLREELE--------SQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNA 1324
Cdd:TIGR00618  440 AELCAAAITCTAQCEKLEKIHLQESAQSLKEREQqlqtkeqiHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQD 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1325 AKE-KALQQLREQLEGERK---EAVATLEKEHSAELERLcSSLEAKHREVVSSLQKKIQEAQQ-KEEAQ-LQKCLGQVEH 1398
Cdd:TIGR00618  520 IDNpGPLTRRMQRGEQTYAqleTSEEDVYHQLTSERKQR-ASLKEQMQEIQQSFSILTQCDNRsKEDIPnLQNITVRLQD 598

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1399 RVHQKSyhvagyEHELSSLLREKRQEVEGEHERRL--------DKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGEL 1470
Cdd:TIGR00618  599 LTEKLS------EAEDMLACEQHALLRKLQPEQDLqdvrlhlqQCSQELALKLTALHALQLTLTQERVREHALSIRVLPK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1471 ERLQR--AHERELE-----------------TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKdvkarlALLEVQE 1531
Cdd:TIGR00618  673 ELLASrqLALQKMQsekeqltywkemlaqcqTLLRELETHIEEYDREFNEIENASSSLGSDLAARED------ALNQSLK 746

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1532 ETARREKQQLLDVQRQVALKSEEATATHQQLEEAQkehtHLLQSNQQLREILDELQARKLKLESQV 1597
Cdd:TIGR00618  747 ELMHQARTVLKARTEAHFNNNEEVTAALQTGAELS----HLAAEIQFFNRLREEDTHLLKTLEAEI 808
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1477-1794 8.35e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 61.23  E-value: 8.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1477 HERELETVR-----QEQHKRLEDLRRrhrEQERKLQDLEL---------DLETRAKDVKARLALLEVQEETARRE--KQQ 1540
Cdd:TIGR02168  171 KERRKETERklertRENLDRLEDILN---ELERQLKSLERqaekaerykELKAELRELELALLVLRLEELREELEelQEE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1541 LLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAE--- 1617
Cdd:TIGR02168  248 LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQlee 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1618 -AQKKQHLLREVT-VEENNASphFEPDlhIEDLRKSLGT-NQTKEVSSSLSQSKEDLYLDslsshnvwhlLSAEGVALRS 1694
Cdd:TIGR02168  328 lESKLDELAEELAeLEEKLEE--LKEE--LESLEAELEElEAELEELESRLEELEEQLET----------LRSKVAQLEL 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1695 AKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPpgikALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEK 1774
Cdd:TIGR02168  394 QIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA----ELKELQAELEELEEELEELQEELERLEEALEELREE 469

                          330       340
                   ....*....|....*....|
gi 1034572500 1775 LNQLESSLWEEASDEGTLGG 1794
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQA 489
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1171-1636 9.67e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 60.96  E-value: 9.67e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVLEQDQRHLLESKQekmqqLREKLCQEEEEeiLRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQ 1250
Cdd:pfam01576  130 EAKIKKLEEDILLLEDQNSKLSKERKL-----LEERISEFTSN--LAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKG 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 RLSWLRAQVQSSTQADE--DQIR------AEQEASLQKLREELES------QQKAERASLEQKNRQMLEQLKEEIEASEk 1316
Cdd:pfam01576  203 RQELEKAKRKLEGESTDlqEQIAelqaqiAELRAQLAKKEEELQAalarleEETAQKNNALKKIRELEAQISELQEDLE- 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1317 SEQAALNAAkEKALQQLREQLEGERKEAVATL-----EKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQK 1391
Cdd:pfam01576  282 SERAARNKA-EKQRRDLGEELEALKTELEDTLdttaaQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEE 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1392 CLGQVEHRVHQKS---YHVAGYEHELSSLLREKR--QEVEGEHERRLDKMKEEHQQVMAKAREQyeAEERKQRAELLGHL 1466
Cdd:pfam01576  361 LTEQLEQAKRNKAnleKAKQALESENAELQAELRtlQQAKQDSEHKRKKLEGQLQELQARLSES--ERQRAELAEKLSKL 438

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1467 TGELERLQRAHErELETVRQEQHKRLEDLrrrhreqERKLQDLE--LDLETRAK------------DVKARLALLEVQEE 1532
Cdd:pfam01576  439 QSELESVSSLLN-EAEGKNIKLSKDVSSL-------ESQLQDTQelLQEETRQKlnlstrlrqledERNSLQEQLEEEEE 510

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1533 TARREKQQLLDVQRQVA---LKSEEATATHQQLEEAQKEHTHLLQS-NQQLRE---ILDELQARKLKLESQVDLLQAQSQ 1605
Cdd:pfam01576  511 AKRNVERQLSTLQAQLSdmkKKLEEDAGTLEALEEGKKRLQRELEAlTQQLEEkaaAYDKLEKTKNRLQQELDDLLVDLD 590

                          490       500       510
                   ....*....|....*....|....*....|.
gi 1034572500 1606 QLQKHFSSLEaeaqKKQHLLREVTVEENNAS 1636
Cdd:pfam01576  591 HQRQLVSNLE----KKQKKFDQMLAEEKAIS 617
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1027-1385 1.30e-08

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 60.16  E-value: 1.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1027 KGLEESSLPALQMEGPDS-AALPGLTRLSPPLPHEERAQSPPRSLATEEEPPQGP-EGQPEWKEAEELGEDSAASLSLQL 1104
Cdd:pfam09731   51 LGEDPPLAPKPKTFRPLQpSVVSAVTGESKEPKEEKKQVKIPRQSGVSSEVAEEEkEATKDAAEAKAQLPKSEQEKEKAL 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1105 SLQREQAPSPPAACeKGKEQHSQAEELGPGQEEAEDPEEkvavSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQV 1184
Cdd:pfam09731  131 EEVLKEAISKAESA-TAVAKEAKDDAIQAVKAHTDSLKE----ASDTAEISREKATDSALQKAEALAEKLKEVINLAKQS 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1185 LEQDQRHLLESKQEKMQQLREKLCQEEEEEilrlhqQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQ---S 1261
Cdd:pfam09731  206 EEEAAPPLLDAAPETPPKLPEHLDNVEEKV------EKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKednL 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1262 STQADEDQIRAEQEASLQKLREELESQQKAERASLEQKnrqmLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGER 1341
Cdd:pfam09731  280 LSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERA----LEKQKEELDKLAEELSARLEEVRAADEAQLRLEFERER 355

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1034572500 1342 KEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKE 1385
Cdd:pfam09731  356 EEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQD 399
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1319-1557 1.65e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.01  E-value: 1.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1319 QAALNAAKEKALQQLREQLEgERKEAVATLEKEHSAELERLcssleAKHREVVSSLQKKIQEAQQkEEAQLQKCLGQVEH 1398
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIA-ELEKELAALKKEEKALLKQL-----AALERRIAALARRIRALEQ-ELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1399 RVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRahe 1478
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA--- 167

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572500 1479 rELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATA 1557
Cdd:COG4942    168 -ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1292-1789 1.80e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.67  E-value: 1.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1292 ERAS--------LEQKNRQMLEQLKEEIEASEKSE-QAALNAAkEKALQQLREQL---EGERKEAVATLEK------EHS 1353
Cdd:PRK02224   169 ERASdarlgverVLSDQRGSLDQLKAQIEEKEEKDlHERLNGL-ESELAELDEEIeryEEQREQARETRDEadevleEHE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1354 AELERLcSSLEAKHREvvssLQKKIQEAQQKEEAqlqkclgqVEHRVHQKSYHVAGYEHELSSLLREkrQEVEGEHERRL 1433
Cdd:PRK02224   248 ERREEL-ETLEAEIED----LRETIAETEREREE--------LAEEVRDLRERLEELEEERDDLLAE--AGLDDADAEAV 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1434 DKMKEEHQQVMAKAREQYEaEERKQRAELLGHLTGELERLQRAHER--ELETVRQEQHKRLEDLRRRHREQERKLQDLEL 1511
Cdd:PRK02224   313 EARREELEDRDEELRDRLE-ECRVAAQAHNEEAESLREDADDLEERaeELREEAAELESELEEAREAVEDRREEIEELEE 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1512 DLEtrakDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQS------NQQLR----- 1580
Cdd:PRK02224   392 EIE----ELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAgkcpecGQPVEgsphv 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1581 EILDELQARKLKLESQVDLLQAQSQQLQKHFSSLE--AEAQKKQHLLREV--TVEEnnasphfepdlHIEDLRKSLgtNQ 1656
Cdd:PRK02224   468 ETIEEDRERVEELEAELEDLEEEVEEVEERLERAEdlVEAEDRIERLEERreDLEE-----------LIAERRETI--EE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1657 TKEVSSSLSQSKEDlyldslsshnvwhlLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPG 1736
Cdd:PRK02224   535 KRERAEELRERAAE--------------LEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAA 600

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1737 IKALEDMRKNLEKETRHLDEMKSAMRKghnLLKKKEEKLNQLESSLWEEASDE 1789
Cdd:PRK02224   601 IADAEDEIERLREKREALAELNDERRE---RLAEKRERKRELEAEFDEARIEE 650
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1167-1785 1.97e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 59.99  E-value: 1.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMRE 1246
Cdd:pfam02463  287 ELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQE 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1247 EESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERAS--LEQKNRQMLEQLKEEIEASEKSEQAALNA 1324
Cdd:pfam02463  367 KLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARqlEDLLKEEKKEELEILEEEEESIELKQGKL 446

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1325 AKEKALQQLRE------QLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQK---CLGQ 1395
Cdd:pfam02463  447 TEEKEELEKQElkllkdELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGvggRIIS 526

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1396 VEHRVHQKSYHVAGYEHELSSL-----LREKRQEVEGEHERR---------------LDKMKEEHQQVMAKAREQYEAEE 1455
Cdd:pfam02463  527 AHGRLGDLGVAVENYKVAISTAvivevSATADEVEERQKLVRaltelplgarklrllIPKLKLPLKSIAVLEIDPILNLA 606

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1456 RKQRAELLGHLTGELERLQRAHERE-LETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEetA 1534
Cdd:pfam02463  607 QLDKATLEADEDDKRAKVVEGILKDtELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQE--K 684

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1535 RREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQvDLLQAQSQQLQKHFSSL 1614
Cdd:pfam02463  685 AESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKID-EEEEEEEKSRLKKEEKE 763

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1615 EAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLG-TNQTKEVSSSLSQSKEDLYLDSLSSH---NVWHLLSAEGV 1690
Cdd:pfam02463  764 EEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEElRALEEELKEEAELLEEEQLLIEQEEKikeEELEELALELK 843

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1691 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKK 1770
Cdd:pfam02463  844 EEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERI 923

                          650
                   ....*....|....*
gi 1034572500 1771 KEEKLNQLESSLWEE 1785
Cdd:pfam02463  924 KEEAEILLKYEEEPE 938
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1409-1757 2.02e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 59.70  E-value: 2.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1409 GYEHELSSLLREKRqEVEGEHERRLDKMKEEHQQV--MAKAREQYEAEERKQRAELlghltGELERLQRAHERELETVRQ 1486
Cdd:TIGR02169  685 GLKRELSSLQSELR-RIENRLDELSQELSDASRKIgeIEKEIEQLEQEEEKLKERL-----EELEEDLSSLEQEIENVKS 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1487 EqhkrLEDLRRRHREQERKLQDLELDLEtrakDVKARLALLEVQEETARREKQQLlDVQRQVAlkseeatathqQLEEAQ 1566
Cdd:TIGR02169  759 E----LKELEARIEELEEDLHKLEEALN----DLEARLSHSRIPEIQAELSKLEE-EVSRIEA-----------RLREIE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1567 KEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEennasphfepdlhIE 1646
Cdd:TIGR02169  819 QKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESR-------------LG 885

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1647 DLRKslgtnQTKEVSSSLSQSKEdlyldslsshnvwhllsaegvALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS 1726
Cdd:TIGR02169  886 DLKK-----ERDELEAQLRELER---------------------KIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDP 939

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1034572500 1727 AQEVAKDPPGIKALEDMRKNLEKETRHLDEM 1757
Cdd:TIGR02169  940 KGEDEEIPEEELSLEDVQAELQRVEEEIRAL 970
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1251-1596 2.17e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.67  E-value: 2.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 RLSWLRAQVQSSTQADEDQIRAEQEASLQKLREEL---ESQQKAERASLEQKN---------RQMLEQLKEEIEASEKSE 1318
Cdd:PRK02224   188 SLDQLKAQIEEKEEKDLHERLNGLESELAELDEEIeryEEQREQARETRDEADevleeheerREELETLEAEIEDLRETI 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1319 qaalnAAKEKALQQLREQLEgERKEAVATLEKEHSAELERlcSSLEAKHREVVSSLqkkiQEAQQKEEAQLQKCLGQVEH 1398
Cdd:PRK02224   268 -----AETEREREELAEEVR-DLRERLEELEEERDDLLAE--AGLDDADAEAVEAR----REELEDRDEELRDRLEECRV 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1399 RVHQKSYHVAGYEHELSSL------LREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEER-----KQRAELLGHLT 1467
Cdd:PRK02224   336 AAQAHNEEAESLREDADDLeeraeeLREEAAELESELEEAREAVEDRREEIEELEEEIEELRERfgdapVDLGNAEDFLE 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1468 GELERLQRAHER--ELETVRQEQHKRLEDLRR------------------------RHREQERKLQDLELDLETRAKDVK 1521
Cdd:PRK02224   416 ELREERDELREReaELEATLRTARERVEEAEAlleagkcpecgqpvegsphvetieEDRERVEELEAELEDLEEEVEEVE 495

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034572500 1522 ARLALLEVQEETARR---EKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREildelQARKLKLESQ 1596
Cdd:PRK02224   496 ERLERAEDLVEAEDRierLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKRE-----AAAEAEEEAE 568
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1369-1598 2.83e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 59.31  E-value: 2.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1369 EVVSSLQKKIQEAQQ--KEEAQLQKCLGQVEHRVHQKSYHVagyeHELSSLLREKRQEVEGEHER--RLDKMKEEhqqvM 1444
Cdd:PRK03918   169 EVIKEIKRRIERLEKfiKRTENIEELIKEKEKELEEVLREI----NEISSELPELREELEKLEKEvkELEELKEE----I 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1445 AKAREQYEAEERKQRA--ELLGHLTGELERLqRAHERELETVRQE---------QHKRLEDLRRRHREQERKLQDLELDL 1513
Cdd:PRK03918   241 EELEKELESLEGSKRKleEKIRELEERIEEL-KKEIEELEEKVKElkelkekaeEYIKLSEFYEEYLDELREIEKRLSRL 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1514 ETRAKDVKARLALLEVQEETARREKQQLLDVQRQV------ALKSEEATATHQQLEEAQKEHTHLlqSNQQLREILDELQ 1587
Cdd:PRK03918   320 EEEINGIEERIKELEEKEERLEELKKKLKELEKRLeeleerHELYEEAKAKKEELERLKKRLTGL--TPEKLEKELEELE 397

                          250
                   ....*....|.
gi 1034572500 1588 ARKLKLESQVD 1598
Cdd:PRK03918   398 KAKEEIEEEIS 408
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1272-1531 2.95e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 2.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1272 AEQEASLQKLREELESQQKA-ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKaLQQLREQLEGERKEaVATLEK 1350
Cdd:PRK03918   469 KEIEEKERKLRKELRELEKVlKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEE-YEKLKEKLIKLKGE-IKSLKK 546

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1351 EHS--AELERLCSSLEAKHREV---VSSLQKKIQEAQQKEEAQLQKCLGQVEhRVHQKSYHVAGYEHELSSLLREKRQEv 1425
Cdd:PRK03918   547 ELEklEELKKKLAELEKKLDELeeeLAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKELEREEKELKKL- 624

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1426 egehERRLDKMKEEHQQVMAKARE----------QYEAEERKQRAELLGHLTGELERLqRAHERELETVRQEQHKRLEDL 1495
Cdd:PRK03918   625 ----EEELDKAFEELAETEKRLEElrkeleelekKYSEEEYEELREEYLELSRELAGL-RAELEELEKRREEIKKTLEKL 699

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1034572500 1496 RRRHREQERKLQDLEL---------DLETRAKDVKARL---ALLEVQE 1531
Cdd:PRK03918   700 KEELEEREKAKKELEKlekalerveELREKVKKYKALLkerALSKVGE 747
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1429-1598 3.34e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 58.63  E-value: 3.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1429 HERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELEtvRQEQHKRLEDLRRRHREQERKLQD 1508
Cdd:COG4717     66 PELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELE--KLEKLLQLLPLYQELEALEAELAE 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1509 LEldleTRAKDVKARLALLEVQEETARREKQQLLDVQRQVA-LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQ 1587
Cdd:COG4717    144 LP----ERLEELEERLEELRELEEELEELEAELAELQEELEeLLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219

                          170
                   ....*....|.
gi 1034572500 1588 ARKLKLESQVD 1598
Cdd:COG4717    220 EELEELEEELE 230
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1374-1781 4.00e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 58.63  E-value: 4.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1374 LQKKIQEAQQKEE--AQLQKCLGQVEHRVHQKSYHVAGYEHELSSL-----LREKRQEVEgEHERRLDKMKEEHQQVMAK 1446
Cdd:COG4717     76 LEEELKEAEEKEEeyAELQEELEELEEELEELEAELEELREELEKLekllqLLPLYQELE-ALEAELAELPERLEELEER 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1447 AREQYEAEERKQRAEllghltGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLET---RAKDVKAR 1523
Cdd:COG4717    155 LEELRELEEELEELE------AELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEaqeELEELEEE 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1524 LALLEVQEETArREKQQLLDVQRQVALKSE--EATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQvdllq 1601
Cdd:COG4717    229 LEQLENELEAA-ALEERLKEARLLLLIAAAllALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGK----- 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1602 aqsqqlqkhfSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGT-NQTKEVSSSLSQSKEDLYLDSLSSHN 1680
Cdd:COG4717    303 ----------EAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRiEELQELLREAEELEEELQLEELEQEI 372

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1681 VwHLLSAEGVALRSAKEFLVQQTrsmrRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSA 1760
Cdd:COG4717    373 A-ALLAEAGVEDEEELRAALEQA----EEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEE 447

                          410       420
                   ....*....|....*....|.
gi 1034572500 1761 MRKGHNLLKKKEEKLNQLESS 1781
Cdd:COG4717    448 LEELREELAELEAELEQLEED 468
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1277-1535 4.02e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.77  E-value: 4.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1277 SLQKLREELES-QQKAERAsleQKNRQMLEQLKEEIE--ASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHS 1353
Cdd:COG4913    229 ALVEHFDDLERaHEALEDA---REQIELLEPIRELAEryAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELA 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1354 AELERL--CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLlrekrQEVEGEHER 1431
Cdd:COG4913    306 RLEAELerLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAAL-----GLPLPASAE 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1432 RLDKMKEEHQQvmakAREQYEAEERKQRAELlghltGELERLQRAHERELETVRQEqhkrLEDLRRRHREQERKLQDLEL 1511
Cdd:COG4913    381 EFAALRAEAAA----LLEALEEELEALEEAL-----AEAEAALRDLRRELRELEAE----IASLERRKSNIPARLLALRD 447

                          250       260
                   ....*....|....*....|....*...
gi 1034572500 1512 DLETRAKDVKARLA----LLEVQEETAR 1535
Cdd:COG4913    448 ALAEALGLDEAELPfvgeLIEVRPEEER 475
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1184-1554 4.05e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.77  E-value: 4.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1184 VLEQDQRHLLESKQEKMQQLREKLcQEEEEEILRLHQQKEQsLSSLRERLQKAIEEEEARMREEESQR-LSWLRAQVQSS 1262
Cdd:COG4913    603 VLGFDNRAKLAALEAELAELEEEL-AEAEERLEALEAELDA-LQERREALQRLAEYSWDEIDVASAEReIAELEAELERL 680

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1263 TQADED-----QIRAEQEASLQKLREELEsQQKAERASLEQKnrqmLEQLKEEIEASekseQAALNAAKEKALQQLREQL 1337
Cdd:COG4913    681 DASSDDlaaleEQLEELEAELEELEEELD-ELKGEIGRLEKE----LEQAEEELDEL----QDRLEAAEDLARLELRALL 751

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1338 EGERKEA-VATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQkclgqvEHRVHQKSYHvaGYEHELSS 1416
Cdd:COG4913    752 EERFAAAlGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNREWPAETA------DLDADLESLP--EYLALLDR 823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1417 LLREKRQEVEGEHERRLDKMKEEH----QQVMAKAREqyEAEERkqraelLGHLTGELERLQRAHERELE-TVRQEQHKR 1491
Cdd:COG4913    824 LEEDGLPEYEERFKELLNENSIEFvadlLSKLRRAIR--EIKER------IDPLNDSLKRIPFGPGRYLRlEARPRPDPE 895

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034572500 1492 LEDLRRRHREQERKLQDLELDL-ETRAKDVKARLALLEVQE-ETARREKQQLLDVQRQVALKSEE 1554
Cdd:COG4913    896 VREFRQELRAVTSGASLFDEELsEARFAALKRLIERLRSEEeESDRRWRARVLDVRNHLEFDAEE 960
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1275-1509 4.28e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 58.81  E-value: 4.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1275 EASLQKLRE---ELESQQKAERASlEQKNRQMLEQLKEEIEASEK-SEQAALNAAKEKA--LQQLREQLEgERKEAVATL 1348
Cdd:COG3096    835 EAELAALRQrrsELERELAQHRAQ-EQQLRQQLDQLKEQLQLLNKlLPQANLLADETLAdrLEELREELD-AAQEAQAFI 912

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1349 EK--EHSAELERLCSSLEAKhREVVSSLQKKIQEAQQKEEAQLQKC--LGQVEHRVHQKSYHVA----GYEHELSSLLRE 1420
Cdd:COG3096    913 QQhgKALAQLEPLVAVLQSD-PEQFEQLQADYLQAKEQQRRLKQQIfaLSEVVQRRPHFSYEDAvgllGENSDLNEKLRA 991

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1421 KRQEVEGEHERRLDKMK------EEHQQVMAKAREQYEAeerkqRAELLGHLTGELERL---------QRAHER------ 1479
Cdd:COG3096    992 RLEQAEEARREAREQLRqaqaqySQYNQVLASLKSSRDA-----KQQTLQELEQELEELgvqadaeaeERARIRrdelhe 1066

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1034572500 1480 ----------ELETVRQEQHKRLEDLRRRHREQERKLQDL 1509
Cdd:COG3096   1067 elsqnrsrrsQLEKQLTRCEAEMDSLQKRLRKAERDYKQE 1106
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1252-1487 6.97e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 6.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1252 LSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQknrqmLEQLKEEIEASEK------SEQAALNA- 1324
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ-----LAALERRIAALARriraleQELAALEAe 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1325 -----AKEKALQQLREQLEGERKEAVATLEKEHSA-ELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEH 1398
Cdd:COG4942     85 laeleKEIAELRAELEAQKEELAELLRALYRLGRQpPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAA 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1399 RVHQKSYHVAgyehELSSLLREKRQEvegehERRLDKMKEEHQQVMAKAREQYEAEErkQRAELLGHLTGELERLQRAHE 1478
Cdd:COG4942    165 LRAELEAERA----ELEALLAELEEE-----RAALEALKAERQKLLARLEKELAELA--AELAELQQEAEELEALIARLE 233


                   ....*....
gi 1034572500 1479 RELETVRQE 1487
Cdd:COG4942    234 AEAAAAAER 242
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1174-1552 7.52e-08

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 57.66  E-value: 7.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1174 LKAMEEAVAQVLEQDQrhllESKQEKMQQLREKlcqeeeeeILRLHQQKEQ---SLSSLRERLQKAIeeeearmreeesQ 1250
Cdd:COG5185    248 LAQTSDKLEKLVEQNT----DLRLEKLGENAES--------SKRLNENANNlikQFENTKEKIAEYT------------K 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 RLSWLRAQVQSSTQADedqiRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKE----------EIEASEKSEQA 1320
Cdd:COG5185    304 SIDIKKATESLEEQLA----AAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAikeeienivgEVELSKSSEEL 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1321 -----ALNAAKEKALQQLREQlEGERKEAVATLE---KEHSAELERLCSSLEAKHREVvsslqkkiqEAQQKEEAQLQKC 1392
Cdd:COG5185    380 dsfkdTIESTKESLDEIPQNQ-RGYAQEILATLEdtlKAADRQIEELQRQIEQATSSN---------EEVSKLLNELISE 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1393 LGQVEHRVhqksyhvagyEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREqyeaeerkqraellghLTGELER 1472
Cdd:COG5185    450 LNKVMREA----------DEESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVST----------------LKATLEK 503

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1473 LQRAHERELETVRQEQHKRLEDLRRRHREQErklQDLELDLETRAKDVKARLALLE--VQEETARREKQQLLDVQRQVAL 1550
Cdd:COG5185    504 LRAKLERQLEGVRSKLDQVAESLKDFMRARG---YAHILALENLIPASELIQASNAktDGQAANLRTAVIDELTQYLSTI 580


                   ..
gi 1034572500 1551 KS 1552
Cdd:COG5185    581 ES 582
PRK12704 PRK12704
phosphodiesterase; Provisional
 1169-1357 1.75e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 56.32  E-value: 1.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1169 LSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKlcqeeeeeILRLHQQKEQSLSSLRERLQkaieeeearmreee 1248
Cdd:PRK12704    28 IAEAKIKEAEEEAKRILEEAKKEAEAIKKEALLEAKEE--------IHKLRNEFEKELRERRNELQ-------------- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1249 sqrlswlraQVQSSTQADEDQIRAEQEaSLQKLREELESQQKaeraSLEQKNRQmLEQLKEEIEASEKSEQAAL----NA 1324
Cdd:PRK12704    86 ---------KLEKRLLQKEENLDRKLE-LLEKREEELEKKEK----ELEQKQQE-LEKKEEELEELIEEQLQELerisGL 150

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1034572500 1325 AKEKALQQLREQLEGE-RKEAVATL-EKEHSAELE 1357
Cdd:PRK12704   151 TAEEAKEILLEKVEEEaRHEAAVLIkEIEEEAKEE 185
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
 1255-1394 1.82e-07

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 461130 [Multi-domain]  Cd Length: 215  Bit Score: 53.92  E-value: 1.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1255 LRAQVQSSTQADED------QIRAEQEASLQKLREELEsQQKAERASLEQKnrqmLEQLKEEIEASEKSEQAALNAAKE- 1327
Cdd:pfam04012    9 VRANIHEGLDKAEDpekmleQAIRDMQSELVKARQALA-QTIARQKQLERR----LEQQTEQAKKLEEKAQAALTKGNEe 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1328 ---KALQQlREQLEG--ERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQK-KIQEAQQKEEAQLQKCLG 1394
Cdd:pfam04012   84 larEALAE-KKSLEKqaEALETQLAQQRSAVEQLRKQLAALETKIQQLKAKKNLlKARLKAAKAQEAVQTSLG 155
PTZ00121 PTZ00121
MAEBL; Provisional
 1308-1786 1.98e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 56.69  E-value: 1.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1308 KEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAElerlcsslEAKHREVVsslqKKIQEAQQKEEA 1387
Cdd:PTZ00121  1084 KEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAE--------EARKAEDA----RKAEEARKAEDA 1151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1388 QLQKCLGQVEhrvhqksyhvagyEHELSSLLREKRQEVEGEHERRLDKMKEEHQqvMAKAREQYEAEERKQRAELLghlt 1467
Cdd:PTZ00121  1152 KRVEIARKAE-------------DARKAEEARKAEDAKKAEAARKAEEVRKAEE--LRKAEDARKAEAARKAEEER---- 1212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1468 gELERLQRAHE-RELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQR 1546
Cdd:PTZ00121  1213 -KAEEARKAEDaKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKK 1291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1547 QVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLR 1626
Cdd:PTZ00121  1292 ADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEK 1371

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1627 EVTVEENNASphfEPDLHIEDLRKSlgtNQTKEVSSSLSQSKEDLYLDSLSSHNVwHLLSAEGVALRSAKEfLVQQTRSM 1706
Cdd:PTZ00121  1372 KKEEAKKKAD---AAKKKAEEKKKA---DEAKKKAEEDKKKADELKKAAAAKKKA-DEAKKKAEEKKKADE-AKKKAEEA 1443

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1707 RRRQTALKAAQqhwrhELASAQEVAKDPPGIKALEDMRKNLEkETRHLDEMK----SAMRKGHNLLKKKEEKLNQLESSL 1782
Cdd:PTZ00121  1444 KKADEAKKKAE-----EAKKAEEAKKKAEEAKKADEAKKKAE-EAKKADEAKkkaeEAKKKADEAKKAAEAKKKADEAKK 1517


                   ....
gi 1034572500 1783 WEEA 1786
Cdd:PTZ00121  1518 AEEA 1521
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1185-1597 2.45e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.18  E-value: 2.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1185 LEQDQRHLLESKQEKMQQLREKlcqeeEEEILRLHQQKEQSLSSL---RERLQKAIEEEEARmreeeSQRLSWLRAQVQS 1261
Cdd:TIGR04523  223 LKKQNNQLKDNIEKKQQEINEK-----TTEISNTQTQLNQLKDEQnkiKKQLSEKQKELEQN-----NKKIKELEKQLNQ 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1262 STQADEDQIRAEQEASLQKLREELESQQKAERASLEQ--KNRQMLEQLKEEIEASEKSEQAalnaaKEKALQQLREQLEg 1339
Cdd:TIGR04523  293 LKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQisQNNKIISQLNEQISQLKKELTN-----SESENSEKQRELE- 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1340 ERKEAVATLEKEHSAELERLcSSLEAKHREVVSSLQKKIQEAQQKEE--AQLQKCLGQVEHRVHQKSYHVAGYEHELSSL 1417
Cdd:TIGR04523  367 EKQNEIEKLKKENQSYKQEI-KNLESQINDLESKIQNQEKLNQQKDEqiKKLQQEKELLEKEIERLKETIIKNNSEIKDL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1418 lREKRQEVEGEHERrLDKMKEEHQQVMAKAREQYEAEER--KQRAELLGHLTGELERLQRaHERELE------TVRQEQH 1489
Cdd:TIGR04523  446 -TNQDSVKELIIKN-LDNTRESLETQLKVLSRSINKIKQnlEQKQKELKSKEKELKKLNE-EKKELEekvkdlTKKISSL 522

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1490 K-RLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE---------------ETARREKQQLL--------DVQ 1545
Cdd:TIGR04523  523 KeKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDEknkeieelkqtqkslKKKQEEKQELIdqkekekkDLI 602

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034572500 1546 RQVALKSEEATATHQQLEEAQKEhthllqsNQQLREILDELQARKLKLESQV 1597
Cdd:TIGR04523  603 KEIEEKEKKISSLEKELEKAKKE-------NEKLSSIIKNIKSKKNKLKQEV 647
PRK12704 PRK12704
phosphodiesterase; Provisional
 1272-1461 2.95e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 55.55  E-value: 2.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1272 AEQEASLQKLREELESQQKAERASLEQKnrQMLEQLKEEIEAsEKSEQAALNAAKEKALQQLREQLEgERKEAvatLEKE 1351
Cdd:PRK12704    36 AEEEAKRILEEAKKEAEAIKKEALLEAK--EEIHKLRNEFEK-ELRERRNELQKLEKRLLQKEENLD-RKLEL---LEKR 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1352 hSAELERLCSSLEAKHREvvssLQKKIQEAQQKEEAQLQKCLgqvehrvhqksyHVAGYEHElssllrEKRQEVegeher 1431
Cdd:PRK12704   109 -EEELEKKEKELEQKQQE----LEKKEEELEELIEEQLQELE------------RISGLTAE------EAKEIL------ 159

                          170       180       190
                   ....*....|....*....|....*....|
gi 1034572500 1432 rLDKMKEEHQQVMAKAREQYEaEERKQRAE 1461
Cdd:PRK12704   160 -LEKVEEEARHEAAVLIKEIE-EEAKEEAD 187
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 1303-1627 3.13e-07

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 55.04  E-value: 3.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1303 MLEQLKEEIEASEKSEQAALNAAKEK-ALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEA 1381
Cdd:pfam15558   13 MLARHKEEQRMRELQQQAALAWEELRrRDQKRQETLERERRLLLQQSQEQWQAEKEQRKARLGREERRRADRREKQVIEK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1382 QQKEEAQLQKclgqVEHRVHQKsyhvagyehelsslLREKRQEVEG---EHERRLdKMKEEHQQVMaKAREQYEAEERKQ 1458
Cdd:pfam15558   93 ESRWREQAED----QENQRQEK--------------LERARQEAEQrkqCQEQRL-KEKEEELQAL-REQNSLQLQERLE 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1459 RAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLqDLELDLeTRAKDVKARLALLEVQE--ETARR 1536
Cdd:pfam15558  153 EACHKRQLKEREEQKKVQENNLSELLNHQARKVLVDCQAKAEELLRRL-SLEQSL-QRSQENYEQLVEERHRElrEKAQK 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1537 EKQQLLDVQRQVALKSEEatathqqleeaQKEHthllqsnqqlREILDELQARKLKLESQVdlLQAQSQQLQKHFSSLEA 1616
Cdd:pfam15558  231 EEEQFQRAKWRAEEKEEE-----------RQEH----------KEALAELADRKIQQARQV--AHKTVQDKAQRARELNL 287

                          330
                   ....*....|.
gi 1034572500 1617 EAQKKQHLLRE 1627
Cdd:pfam15558  288 EREKNHHILKL 298
mukB PRK04863
chromosome partition protein MukB;
1187-1598 3.54e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 55.73  E-value: 3.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1187 QDQRHLLESKQEKMQQLREKLcqeeeEEILRLHQQKEQSLSSLRERLQKaieeeearmreeesqrlswlraqVQSSTQAD 1266
Cdd:PRK04863   296 YTSRRQLAAEQYRLVEMAREL-----AELNEAESDLEQDYQAASDHLNL-----------------------VQTALRQQ 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1267 EDQIRAEqeASLQKLREELESQQKAERASLEQK--NRQMLEQLKEEIEaSEKSE----QAALNAAKEKALQQlreqlege 1340
Cdd:PRK04863   348 EKIERYQ--ADLEELEERLEEQNEVVEEADEQQeeNEARAEAAEEEVD-ELKSQladyQQALDVQQTRAIQY-------- 416

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1341 rKEAVATLEKehsaeLERLC--SSLEAKhrevvsSLQKKIQEAQQKEEAQLQKCLgQVEHRVHQKSYHVAGYEHELSSLL 1418
Cdd:PRK04863   417 -QQAVQALER-----AKQLCglPDLTAD------NAEDWLEEFQAKEQEATEELL-SLEQKLSVAQAAHSQFEQAYQLVR 483

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1419 RekrqeVEGEHERrldkmKEEHQQVMAKAREqyeAEERKQRAELLGHLTGELERLQRahereletvRQEQHKRLEDLRR- 1497
Cdd:PRK04863   484 K-----IAGEVSR-----SEAWDVARELLRR---LREQRHLAEQLQQLRMRLSELEQ---------RLRQQQRAERLLAe 541

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1498 ------RHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQL-LDVQR-----------QVAL-----KSEE 1554
Cdd:PRK04863   542 fckrlgKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLqARIQRlaarapawlaaQDALarlreQSGE 621

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1034572500 1555 ATATHQQLEEAQKEHTHLLQSNQQLReilDELQARKLKLESQVD 1598
Cdd:PRK04863   622 EFEDSQDVTEYMQQLLERERELTVER---DELAARKQALDEEIE 662
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1189-1397 3.68e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 3.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1189 QRHLLESKQEKMQQLREKLcqEEEEEILRLHQQKEQSLSSLRERLQKAIEeEEARMREEESQRLSWLRAQVQsSTQADED 1268
Cdd:COG4942     18 QADAAAEAEAELEQLQQEI--AELEKELAALKKEEKALLKQLAALERRIA-ALARRIRALEQELAALEAELA-ELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1269 QIRAEQEASLQKLREELESQQKAERASLEQ------------KNRQMLEQLKEEIEaseksEQAALNAAKEKALQQLREQ 1336
Cdd:COG4942     94 ELRAELEAQKEELAELLRALYRLGRQPPLAlllspedfldavRRLQYLKYLAPARR-----EQAEELRADLAELAALRAE 168

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572500 1337 LEGERKEaVATLEKEHSAELERLcSSLEAKHREVVSSLQKKIQEAQ------QKEEAQLQKCLGQVE 1397
Cdd:COG4942    169 LEAERAE-LEALLAELEEERAAL-EALKAERQKLLARLEKELAELAaelaelQQEAEELEALIARLE 233
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1220-1777 3.75e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 55.57  E-value: 3.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1220 QQKEQSLSSLRERLQKAieeeearmrEEESQRLSWLRAQVQSSTQADEDQIRAEQeaslqklreELESQQKAERASLEQK 1299
Cdd:pfam01576    8 QAKEEELQKVKERQQKA---------ESELKELEKKHQQLCEEKNALQEQLQAET---------ELCAEAEEMRARLAAR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1300 nRQMLEQLKEEIEA--SEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHsaeLERLcsSLEAKhrevvsslQKK 1377
Cdd:pfam01576   70 -KQELEEILHELESrlEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQ---LEKV--TTEAK--------IKK 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1378 IQEAQQKEEAQ---LQKCLGQVEHRVHQKSYHVAGYEHELSSL--LREKRQEVEGEHERRLDKmKEEHQQVMAKAREQYE 1452
Cdd:pfam01576  136 LEEDILLLEDQnskLSKERKLLEERISEFTSNLAEEEEKAKSLskLKNKHEAMISDLEERLKK-EEKGRQELEKAKRKLE 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1453 AEE----------RKQRAELLGHLTGELERLQRAHER-ELETVRQEQhkrledLRRRHREQERKLQDLELDLET----RA 1517
Cdd:pfam01576  215 GEStdlqeqiaelQAQIAELRAQLAKKEEELQAALARlEEETAQKNN------ALKKIRELEAQISELQEDLESeraaRN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1518 KDVKARLALLE-----------------VQEETARREKQQLLDVQRQValkSEEATATHQQLEEAQKEHThllQSNQQLR 1580
Cdd:pfam01576  289 KAEKQRRDLGEelealkteledtldttaAQQELRSKREQEVTELKKAL---EEETRSHEAQLQEMRQKHT---QALEELT 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1581 EILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLR--EVTVEENNASpHFEPDLHIEDLRKSLGTNQTK 1658
Cdd:pfam01576  363 EQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKklEGQLQELQAR-LSESERQRAELAEKLSKLQSE 441

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1659 --EVSSSLSQSKEDLY-----LDSLSSHnvwhllsaegvaLRSAKEFLVQQTR-----SMRRRQTALKAA--QQHWRHEL 1724
Cdd:pfam01576  442 leSVSSLLNEAEGKNIklskdVSSLESQ------------LQDTQELLQEETRqklnlSTRLRQLEDERNslQEQLEEEE 509

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034572500 1725 ASAQEVAKDPPGIKA-LEDMRKNLEKETRHLDEMKSAMRKghnlLKKKEEKLNQ 1777
Cdd:pfam01576  510 EAKRNVERQLSTLQAqLSDMKKKLEEDAGTLEALEEGKKR----LQRELEALTQ 559
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1256-1616 4.09e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 55.73  E-value: 4.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1256 RAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERAsLE---QKNRQMLEQLKEEIEASEKSE--QAALNAAKEKAL 1330
Cdd:COG3096    286 RALELRRELFGARRQLAEEQYRLVEMARELEELSARESD-LEqdyQAASDHLNLVQTALRQQEKIEryQEDLEELTERLE 364

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1331 QQ--LREQLEGERKEAVATLEkEHSAELERLCSSLeAKHREVVSSLQKKIQEAQQKEEAqlqkcLGQVEHRVHQKSYHVA 1408
Cdd:COG3096    365 EQeeVVEEAAEQLAEAEARLE-AAEEEVDSLKSQL-ADYQQALDVQQTRAIQYQQAVQA-----LEKARALCGLPDLTPE 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1409 GYEHELSSLlREKRQEVegeHERRLDKmkEEHQQVMAKAREQYEaeerkQRAELLGHLTGELERLQrAHE--RE-LETVR 1485
Cdd:COG3096    438 NAEDYLAAF-RAKEQQA---TEEVLEL--EQKLSVADAARRQFE-----KAYELVCKIAGEVERSQ-AWQtaRElLRRYR 505

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1486 QEQH--KRLEDLRRRHREQERKL---QDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQ 1560
Cdd:COG3096    506 SQQAlaQRLQQLRAQLAELEQRLrqqQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQ 585

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1561 QLEE-----------------AQKEHTHL-------LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEA 1616
Cdd:COG3096    586 QLEQlrarikelaarapawlaAQDALERLreqsgeaLADSQEVTAAMQQLLEREREATVERDELAARKQALESQIERLSQ 665
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1167-1582 4.96e-07

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 54.91  E-value: 4.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQVLEQD-----QRHLLESKQEKMQQLREKLCQ-EEEEEILRLHQQKEQSLSSLRERLQKAIEEE 1240
Cdd:COG5278    113 EALIDQWLAELEQVIALRRAGGleaalALVRSGEGKALMDEIRARLLLlALALAALLLAAAALLLLLLALAALLALAELL 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1241 EARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQA 1320
Cdd:COG5278    193 LLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALALALLLAALLLALLAALALAALLAAALLALAA 272

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1321 ALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQkclgQVEHRV 1400
Cdd:COG5278    273 LLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAAAAALAALLALALATALAAAAA----ALALLA 348

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1401 HQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERE 1480
Cdd:COG5278    349 ALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIAAAAAAAAAEAAAAAAAAAAASAAEALELAEAL 428

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1481 LETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQ 1560
Cdd:COG5278    429 AEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALAALAAAAAALAEAEAAAALAAAAALSLALALAAL 508

                          410       420
                   ....*....|....*....|..
gi 1034572500 1561 QLEEAQKEHTHLLQSNQQLREI 1582
Cdd:COG5278    509 LLAAAEAALAAALAAALASAEL 530
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1174-1567 6.32e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 54.84  E-value: 6.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1174 LKAMEEAVAQ------VLEQDQRHLLESKQEKMQQLREKLCQ-----EEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 1242
Cdd:pfam12128  310 LSAADAAVAKdrseleALEDQHGAFLDADIETAAADQEQLPSwqselENLEERLKALTGKHQDVTAKYNRRRSKIKEQNN 389

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1243 RMREEESQRLSWLR-------AQVQSSTQADEDQIRAEQEASLQKLREE-LESQQKAERASLEQKNRQMLEQLKEEIEAS 1314
Cdd:pfam12128  390 RDIAGIKDKLAKIReardrqlAVAEDDLQALESELREQLEAGKLEFNEEeYRLKSRLGELKLRLNQATATPELLLQLENF 469

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1315 E------KSEQAALNAAKEkALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHreVVSSLQKKIQEAQQKEEAQ 1388
Cdd:pfam12128  470 DerieraREEQEAANAEVE-RLQSELRQARKRRDQASEALRQASRRLEERQSALDELEL--QLFPQAGTLLHFLRKEAPD 546

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1389 LQKCLGQVE-----HRVHQKSYHVAGYEHELSSL----LREKRQEV------EGEHERRLDKMKEEHQQVMAKAREQYEA 1453
Cdd:pfam12128  547 WEQSIGKVIspellHRTDLDPEVWDGSVGGELNLygvkLDLKRIDVpewaasEEELRERLDKAEEALQSAREKQAAAEEQ 626

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1454 eerkqraelLGHLTGELERLQRAHERELETV--------------RQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 1519
Cdd:pfam12128  627 ---------LVQANGELEKASREETFARTALknarldlrrlfdekQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKK 697

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1520 VKARLALLEVQEETARREKQQLL-----DVQRQVALKSEEATATHQQLEEAQK 1567
Cdd:pfam12128  698 HQAWLEEQKEQKREARTEKQAYWqvvegALDAQLALLKAAIAARRSGAKAELK 750
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1189-1629 8.22e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 54.41  E-value: 8.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1189 QRHLLESKQEKMQQLREKLCQEEEE--EILRLHQQKEQSLSSLRERLQK-----AIEEEEARMREEESQRLSWLRAQVQS 1261
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESElkELEKKHQQLCEEKNALQEQLQAetelcAEAEEMRARLAARKQELEEILHELES 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1262 STQADEDQIRAEQ------EASLQKLREELESQQKA------ERASLEQKNRQMLEQL-----------KE----EIEAS 1314
Cdd:pfam01576   83 RLEEEEERSQQLQnekkkmQQHIQDLEEQLDEEEAArqklqlEKVTTEAKIKKLEEDIllledqnsklsKErkllEERIS 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1315 EKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSA--ELERLCSSLEAKH---REVVSSLQKKIQEAQ---QKEE 1386
Cdd:pfam01576  163 EFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGrqELEKAKRKLEGEStdlQEQIAELQAQIAELRaqlAKKE 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1387 AQLQKCLGQVEHRVHQKSyHVAGYEHELSSLLREKRQEVEGEHERR-------------LDKMKEEHQQVMAKAREQYEA 1453
Cdd:pfam01576  243 EELQAALARLEEETAQKN-NALKKIRELEAQISELQEDLESERAARnkaekqrrdlgeeLEALKTELEDTLDTTAAQQEL 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1454 eeRKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLEldletrakdvKARLALlevqeET 1533
Cdd:pfam01576  322 --RSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLE----------KAKQAL-----ES 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1534 ARREKQQLLDVQRQVALKSEEA-TATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFS 1612
Cdd:pfam01576  385 ENAELQAELRTLQQAKQDSEHKrKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVS 464

                          490
                   ....*....|....*..
gi 1034572500 1613 SLEAEAQKKQHLLREVT 1629
Cdd:pfam01576  465 SLESQLQDTQELLQEET 481
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1330-1707 8.59e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 54.34  E-value: 8.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1330 LQQLREQLEGERKEAVATLEKEHSAELERLCS--------------SLEAKHREVVSSLQ--KKIQEAQQKEEAQLQ--- 1390
Cdd:pfam05483   50 LEQVANSGDCHYQEGLKDSDFENSEGLSRLYSklykeaekikkwkvSIEAELKQKENKLQenRKIIEAQRKAIQELQfen 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1391 -KCLGQVEHRVHQKSYHVA--GYEHELSSLLRE---------KRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQ 1458
Cdd:pfam05483  130 eKVSLKLEEEIQENKDLIKenNATRHLCNLLKEtcarsaektKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENA 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1459 RAELLGHLTGELERLQRAhERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARR-- 1536
Cdd:pfam05483  210 RLEMHFKLKEDHEKIQHL-EEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKEli 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1537 EKQQLL---------DVQRQVALKS--EE----ATATHQQL---EEAQKEHTHLLQSNQQLreILDELQARKLKLESQVD 1598
Cdd:pfam05483  289 EKKDHLtkeledikmSLQRSMSTQKalEEdlqiATKTICQLteeKEAQMEELNKAKAAHSF--VVTEFEATTCSLEELLR 366

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1599 LLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNAsphfepDLHIEDLRKSLGTNQT--------KEVSSSLSQSKED 1670
Cdd:pfam05483  367 TEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNK------EVELEELKKILAEDEKlldekkqfEKIAEELKGKEQE 440

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1034572500 1671 LYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1707
Cdd:pfam05483  441 LIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLK 477
mukB PRK04863
chromosome partition protein MukB;
1272-1522 9.97e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 54.19  E-value: 9.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1272 AEQEASLQKLREELeSQQKAERASLEQKNRQM---LEQLKEEIEASEKSE-QAAL--NAAKEKALQQLREQLEgERKEAV 1345
Cdd:PRK04863   833 ADPEAELRQLNRRR-VELERALADHESQEQQQrsqLEQAKEGLSALNRLLpRLNLlaDETLADRVEEIREQLD-EAEEAK 910

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1346 ATLEK--EHSAELERLCSSLEAKHREVvSSLQKKIQEAQQKEEAQLQKC--LGQVEHRVHQKSYHVA----GYEHELSSL 1417
Cdd:PRK04863   911 RFVQQhgNALAQLEPIVSVLQSDPEQF-EQLKQDYQQAQQTQRDAKQQAfaLTEVVQRRAHFSYEDAaemlAKNSDLNEK 989

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1418 LREKRQEVEGEherrLDKMKEEHQQ----------VMAKAREQYEA-----EERKQRAELLG-HLTGELERLQRAHEREL 1481
Cdd:PRK04863   990 LRQRLEQAEQE----RTRAREQLRQaqaqlaqynqVLASLKSSYDAkrqmlQELKQELQDLGvPADSGAEERARARRDEL 1065

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1034572500 1482 etvrqeqHKRLEDLRRRHREQERKLQDLELDLETRAKDVKA 1522
Cdd:PRK04863  1066 -------HARLSANRSRRNQLEKQLTFCEAEMDNLTKKLRK 1099
PRK00106 PRK00106
ribonuclease Y;
1257-1455 1.22e-06

ribonuclease Y;


Pssm-ID: 178867 [Multi-domain]  Cd Length: 535  Bit Score: 53.33  E-value: 1.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1257 AQVQSSTQADEDQIRAEQEAslQKLREELESQQKAERasleQKNRQMLEQLKEEIEASEKSEQAALNaaKEKALQQLREQ 1336
Cdd:PRK00106    62 AKRESKALKKELLLEAKEEA--RKYREEIEQEFKSER----QELKQIESRLTERATSLDRKDENLSS--KEKTLESKEQS 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1337 LE------GERKEAVATLEKEHSAELERLCSSLEAKHREVVsslqkkiqeaqqkeeaqlqkcLGQVEHRVhqksyhvagy 1410
Cdd:PRK00106   134 LTdkskhiDEREEQVEKLEEQKKAELERVAALSQAEAREII---------------------LAETENKL---------- 182

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1034572500 1411 EHELSSLLREKRQEVegehERRLDKM-KEEHQQVMAKAREQYEAEE 1455
Cdd:PRK00106   183 THEIATRIREAEREV----KDRSDKMaKDLLAQAMQRLAGEYVTEQ 224
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1432-1652 1.27e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.77  E-value: 1.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1432 RLDKMKEEHQQVMAkAREqyEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLEL 1511
Cdd:COG4913    226 AADALVEHFDDLER-AHE--ALEDAREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRA 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1512 D---LETRAKDVKARLALLEVQEETARREKQQlLDVQRQVALKSEEATAThQQLEEAQKEHTHLlqsNQQLREI------ 1582
Cdd:COG4913    303 ElarLEAELERLEARLDALREELDELEAQIRG-NGGDRLEQLEREIERLE-RELEERERRRARL---EALLAALglplpa 377

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034572500 1583 -LDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVE----ENNASPHfepDLHIEDLRKSL 1652
Cdd:COG4913    378 sAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEiaslERRKSNI---PARLLALRDAL 449
PRK12704 PRK12704
phosphodiesterase; Provisional
 1407-1585 1.47e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 53.24  E-value: 1.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1407 VAGYEHELSSLLREKRQEVEGEHERRLDKMKEEhqqvMAKAREQYEAEERKQRAELlghltGELERLQRAHERELEtvrq 1486
Cdd:PRK12704    33 IKEAEEEAKRILEEAKKEAEAIKKEALLEAKEE----IHKLRNEFEKELRERRNEL-----QKLEKRLLQKEENLD---- 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1487 eqhKRLEDLRRRhreqERKLQDLELDLETRAKDVKARlallevQEETARREKQQLLDVQRQVALKSEEATAthQQLEEAQ 1566
Cdd:PRK12704   100 ---RKLELLEKR----EEELEKKEKELEQKQQELEKK------EEELEELIEEQLQELERISGLTAEEAKE--ILLEKVE 164

                          170
                   ....*....|....*....
gi 1034572500 1567 KEHTHllQSNQQLREILDE 1585
Cdd:PRK12704   165 EEARH--EAAVLIKEIEEE 181
PRK12704 PRK12704
phosphodiesterase; Provisional
 1430-1595 1.57e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 53.24  E-value: 1.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1430 ERRLDKMKEEHQQVMAKAREqyEAEERKQRAELlghltgelerlqrahereleTVRQEQHKRLEDLRRRHREQERKLQDL 1509
Cdd:PRK12704    30 EAKIKEAEEEAKRILEEAKK--EAEAIKKEALL--------------------EAKEEIHKLRNEFEKELRERRNELQKL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1510 EldletraKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHthllqsNQQLREI--LDELQ 1587
Cdd:PRK12704    88 E-------KRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQ------LQELERIsgLTAEE 154


                   ....*...
gi 1034572500 1588 ARKLKLES 1595
Cdd:PRK12704   155 AKEILLEK 162
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1171-1589 1.89e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.38  E-value: 1.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEeeeilRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQ 1250
Cdd:COG4913    311 LERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLE-----RELEERERRRARLEALLAALGLPLPASAEEFAAL 385

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 RLSW--LRAQVQSSTQADEDQiRAEQEASLQKLREELEsQQKAERASLEQKN-------RQMLEQLKEEIEASE------ 1315
Cdd:COG4913    386 RAEAaaLLEALEEELEALEEA-LAEAEAALRDLRRELR-ELEAEIASLERRKsniparlLALRDALAEALGLDEaelpfv 463

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1316 ------KSEQAALNAAKEKAL-----------------------QQLREQLEGERKEAVATLEKEHSAELERLCSSLEAK 1366
Cdd:COG4913    464 gelievRPEEERWRGAIERVLggfaltllvppehyaaalrwvnrLHLRGRLVYERVRTGLPDPERPRLDPDSLAGKLDFK 543

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1367 ----HREVVSSLQKKIQEAQQKEEAQLQKC------LGQV--EHRVHQK-------SYHVAGYE-----HELSSLLREKR 1422
Cdd:COG4913    544 phpfRAWLEAELGRRFDYVCVDSPEELRRHpraitrAGQVkgNGTRHEKddrrrirSRYVLGFDnraklAALEAELAELE 623

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1423 QEVEgEHERRLDKMKEEHQQvMAKAREQYEAEERKQRAEL--------LGHLTGELERLQRAHE--RELETVRQEQHKRL 1492
Cdd:COG4913    624 EELA-EAEERLEALEAELDA-LQERREALQRLAEYSWDEIdvasaereIAELEAELERLDASSDdlAALEEQLEELEAEL 701

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1493 EDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQ-KEHTH 1571
Cdd:COG4913    702 EELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERIdALRAR 781

                          490
                   ....*....|....*...
gi 1034572500 1572 LLQSNQQLREILDELQAR 1589
Cdd:COG4913    782 LNRAEEELERAMRAFNRE 799
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1418-1621 1.90e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1418 LREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEER-KQRAELLGHLTGELERLQR---AHERELETVRQEQHKRLE 1493
Cdd:COG4942     25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiAALARRIRALEQELAALEAelaELEKEIAELRAELEAQKE 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1494 DLRRRHREQERKLQDLELDLETRAKDVKA---RLALL----EVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQ 1566
Cdd:COG4942    105 ELAELLRALYRLGRQPPLALLLSPEDFLDavrRLQYLkylaPARREQAEELRADLAELAALRAELEAERAELEALLAELE 184

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034572500 1567 KEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKK 1621
Cdd:COG4942    185 EERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
FAM184 pfam15665
Family with sequence similarity 184, A and B; The function of FAM184 is not known.
 1273-1506 2.02e-06

Family with sequence similarity 184, A and B; The function of FAM184 is not known.


Pssm-ID: 464788 [Multi-domain]  Cd Length: 211  Bit Score: 50.81  E-value: 2.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1273 EQEASLQKLREelesQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAAlnaakeKALQQLREQLEGERKEAVATLEK-E 1351
Cdd:pfam15665   11 EHEAEIQALKE----AHEEEIQQILAETREKILQYKSKIGEELDLKRRI------QTLEESLEQHERMKRQALTEFEQyK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1352 HSAELERLCssLEAKHREVVSSLQKKIQEAQQKEEAQLQKclgqvehrvhqksyhvagyehelsslLREKRQEVEGEHER 1431
Cdd:pfam15665   81 RRVEERELK--AEAEHRQRVVELSREVEEAKRAFEEKLES--------------------------FEQLQAQFEQEKRK 132

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034572500 1432 RLDKMKEEHQQVMAKAREQYEAEERKqraellghLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKL 1506
Cdd:pfam15665  133 ALEELRAKHRQEIQELLTTQRAQSAS--------SLAEQEKLEELHKAELESLRKEVEDLRKEKKKLAEEYEQKL 199
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1419-1591 2.28e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 51.84  E-value: 2.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1419 REKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRR 1498
Cdd:pfam13868   31 KKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERI 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1499 HREQERKLQD-LELDLETR---AKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHT---- 1570
Cdd:pfam13868  111 QEEDQAEAEEkLEKQRQLReeiDEFNEEQAEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIarlr 190

                          170       180
                   ....*....|....*....|.
gi 1034572500 1571 HLLQSNQQLREILDELQARKL 1591
Cdd:pfam13868  191 AQQEKAQDEKAERDELRAKLY 211
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1455-1735 2.29e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.00  E-value: 2.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1455 ERKQRAELLGHLTGELERLQRAHErELETVRqEQHKRLEDLRRRHREQERKLQDLEL--DLETRAKDVKA--RLALLEVQ 1530
Cdd:COG4913    219 EEPDTFEAADALVEHFDDLERAHE-ALEDAR-EQIELLEPIRELAERYAAARERLAEleYLRAALRLWFAqrRLELLEAE 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1531 EETARREKQQLldvQRQVALKSEEATATHQQLEEAQKEHthLLQSNQQLREILDELQARKLKLESQvdllqaqsqqlqkh 1610
Cdd:COG4913    297 LEELRAELARL---EAELERLEARLDALREELDELEAQI--RGNGGDRLEQLEREIERLERELEER-------------- 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1611 fsslEAEAQKKQHLLREVtveennaspHFEPDLHIEDLRKSLgtNQTKEVSSSLSQSKEDLyldslssHNVWHLLSAEGV 1690
Cdd:COG4913    358 ----ERRRARLEALLAAL---------GLPLPASAEEFAALR--AEAAALLEALEEELEAL-------EEALAEAEAALR 415

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1034572500 1691 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPP 1735
Cdd:COG4913    416 DLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEAEL 460
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1270-1635 2.35e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.85  E-value: 2.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1270 IRAEQEASLQKLREELESQQkaerASLEQKNRQMLEQLKEEIEASEKSEQAalNAAKEKALQQLREQLEGERKEavatlE 1349
Cdd:COG4717     43 IRAMLLERLEKEADELFKPQ----GRKPELNLKELKELEEELKEAEEKEEE--YAELQEELEELEEELEELEAE-----L 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1350 KEHSAELERLcssleakhrEVVSSLQKKIQEAQQKEE--AQLQKCLGQVEHRVHQksyhVAGYEHELSSlLREKRQEVEG 1427
Cdd:COG4717    112 EELREELEKL---------EKLLQLLPLYQELEALEAelAELPERLEELEERLEE----LRELEEELEE-LEAELAELQE 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1428 EHERRLDKMKEEHQQVMAKAREQYEA--EERKQRAELLGHLTGELERLQRAHER-ELETVRQEQHKRLEDLRR------- 1497
Cdd:COG4717    178 ELEELLEQLSLATEEELQDLAEELEElqQRLAELEEELEEAQEELEELEEELEQlENELEAAALEERLKEARLllliaaa 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1498 -----------------------------------------RHREQERKLQDLELDLETRAKDVKARLALLEVQEETARR 1536
Cdd:COG4717    258 llallglggsllsliltiagvlflvlgllallflllarekaSLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPE 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1537 EKQQLLDVQRQVALKSEEATATHQQL--EEAQKEHTHLLQSNQ-----QLREILD------ELQARKLKLESQVDLLQAQ 1603
Cdd:COG4717    338 ELLELLDRIEELQELLREAEELEEELqlEELEQEIAALLAEAGvedeeELRAALEqaeeyqELKEELEELEEQLEELLGE 417

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1034572500 1604 SQQLQKHFS--SLEAEAQKKQHLLREVTVEENNA 1635
Cdd:COG4717    418 LEELLEALDeeELEEELEELEEELEELEEELEEL 451
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1284-1581 2.61e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.80  E-value: 2.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1284 ELESQQKAERASLEQKNRQMlEQLKEEIEASEKSEQAALNAAK--EKALQ-------QLREQLEGERKEA---------- 1344
Cdd:pfam05483  272 QLEEKTKLQDENLKELIEKK-DHLTKELEDIKMSLQRSMSTQKalEEDLQiatkticQLTEEKEAQMEELnkakaahsfv 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1345 -------VATLEKEHSAELERLCSSlEAKHREVVSSLQKKIQEAQQK---------EEAQLQKCLGQVEHRVHQK----- 1403
Cdd:pfam05483  351 vtefeatTCSLEELLRTEQQRLEKN-EDQLKIITMELQKKSSELEEMtkfknnkevELEELKKILAEDEKLLDEKkqfek 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1404 -SYHVAGYEHELSSLLREKRQEVEG-EHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGH---LTGELERL-QRAH 1477
Cdd:pfam05483  430 iAEELKGKEQELIFLLQAREKEIHDlEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHcdkLLLENKELtQEAS 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1478 ERELETVRQEQH------------KRLEDLRRRHREQERKLQDLELDLETRAKDVKARLallEVQEETARREKQQLLDVQ 1545
Cdd:pfam05483  510 DMTLELKKHQEDiinckkqeermlKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKL---DKSEENARSIEYEVLKKE 586

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1034572500 1546 RQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLRE 1581
Cdd:pfam05483  587 KQMKILENKCNNLKKQIENKNKNIEELHQENKALKK 622
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1257-1388 2.81e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 51.77  E-value: 2.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1257 AQVQSSTQADEDQIRAEQEAslQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ 1336
Cdd:TIGR02794   50 QQANRIQQQKKPAAKKEQER--QKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAK 127

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572500 1337 LEGERK-------EAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQ 1388
Cdd:TIGR02794  128 QAAEAKakaeaeaERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAE 186
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1349-1627 2.93e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 52.43  E-value: 2.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1349 EKEHSAELERLCSSLEAKHREVvsSLQKKIQEAQQKEEAQLQKclgqvehrvhQKSYHVagyEHELSSLlrekrqevegE 1428
Cdd:pfam17380  291 EKFEKMEQERLRQEKEEKAREV--ERRRKLEEAEKARQAEMDR----------QAAIYA---EQERMAM----------E 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1429 HERRLDKMK-EEHQQVMAKAREQYEAEERKQraellghlTGELERLQRAHERELETVRQE-----QHKRLEDlrrrhrEQ 1502
Cdd:pfam17380  346 RERELERIRqEERKRELERIRQEEIAMEISR--------MRELERLQMERQQKNERVRQEleaarKVKILEE------ER 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1503 ERKLQDLELDLET-RAKDVKARLALLEVQEETARREKQQLldvqRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLRE 1581
Cdd:pfam17380  412 QRKIQQQKVEMEQiRAEQEEARQREVRRLEEERAREMERV----RLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRK 487

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1034572500 1582 ILDELqaRKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1627
Cdd:pfam17380  488 RAEEQ--RRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYE 531
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1250-1589 3.40e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.82  E-value: 3.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1250 QRLSWLRAQVQSSTQADEDQIRAEQEA-SLQKLREELESQ---QKAERASLEQKNRQMLEQLKEEIEASE--KSEQAALN 1323
Cdd:pfam07888   42 ERAELLQAQEAANRQREKEKERYKRDReQWERQRRELESRvaeLKEELRQSREKHEELEEKYKELSASSEelSEEKDALL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1324 AAKEKALQQLREQLEGERKEAVATLEKEhsAELERLcssleaKHREVVSSLQKKIQEAQQKeeaQLQKCLGQVEHRVHQK 1403
Cdd:pfam07888  122 AQRAAHEARIRELEEDIKTLTQRVLERE--TELERM------KERAKKAGAQRKEEEAERK---QLQAKLQQTEEELRSL 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1404 SYHVAGYEHEL----SSLLR-----EKRQEVEGEHERRLDKMKEEHQQvMAKAREQYEAEERKqrAELLGHLTGELERLQ 1474
Cdd:pfam07888  191 SKEFQELRNSLaqrdTQVLQlqdtiTTLTQKLTTAHRKEAENEALLEE-LRSLQERLNASERK--VEGLGEELSSMAAQR 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1475 RAHERELETVRQEQHK---RLEDLRRRHRE------QERK--LQDLELDLETRAKDVKARLALLE-VQEETARREKQQL- 1541
Cdd:pfam07888  268 DRTQAELHQARLQAAQltlQLADASLALREgrarwaQEREtlQQSAEADKDRIEKLSAELQRLEErLQEERMEREKLEVe 347

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1542 ----LDVQR-QVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQAR 1589
Cdd:pfam07888  348 lgreKDCNRvQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQR 400
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1269-1385 5.10e-06

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 51.75  E-value: 5.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1269 QIRAEQEA-SLQKLREELESQQKaeraSLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVAT 1347
Cdd:PRK00409   529 ERELEQKAeEAEALLKEAEKLKE----ELEEKKEKLQEEEDKLLEEAEKEAQQAIKEAKKEADEIIKELRQLQKGGYASV 604

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1034572500 1348 LEKEHSAELERLCSSLEAKHREvvsslqKKIQEAQQKE 1385
Cdd:PRK00409   605 KAHELIEARKRLNKANEKKEKK------KKKQKEKQEE 636
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1258-1590 5.53e-06

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 51.39  E-value: 5.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1258 QVQSSTQADEDQIRAEQEASLQKLREELESqqkaeraslEQKNRQMLEQLKEEIEASEKsEQAALNAAKEKALQQLREQL 1337
Cdd:pfam06160   86 KALDEIEELLDDIEEDIKQILEELDELLES---------EEKNREEVEELKDKYRELRK-TLLANRFSYGPAIDELEKQL 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1338 EgerkeavaTLEKEHSaELERLCSS---LEAkhREVVSSLQKKIQEAQQKEE------AQLQKCL-GQVEhrvhqksyhv 1407
Cdd:pfam06160  156 A--------EIEEEFS-QFEELTESgdyLEA--REVLEKLEEETDALEELMEdipplyEELKTELpDQLE---------- 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1408 agyehELSSLLRE-KRQEVEGEH---ERRLDKMKEEHQQVMA--KAREQYEAEerkqraELLGHLTGELERLQRAHEREL 1481
Cdd:pfam06160  215 -----ELKEGYREmEEEGYALEHlnvDKEIQQLEEQLEENLAllENLELDEAE------EALEEIEERIDQLYDLLEKEV 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1482 ETvRQEQHKRLEDLRRRHREQERKLQDLELDLETrakdVKARLALLEVQEETARREKQQLLDVQRQVAL---KSEEATAT 1558
Cdd:pfam06160  284 DA-KKYVEKNLPEIEDYLEHAEEQNKELKEELER----VQQSYTLNENELERVRGLEKQLEELEKRYDEiveRLEEKEVA 358

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1034572500 1559 H-----------QQLEEAQKEHTHLLQSNQQLREilDELQARK 1590
Cdd:pfam06160  359 YselqeeleeilEQLEEIEEEQEEFKESLQSLRK--DELEARE 399
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1171-1432 6.14e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 51.28  E-value: 6.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVLEQD-QRHLLESKQEKMQQLREKLCQEEEEEIL---RLHQQKEQSLSSLRERL-----QKAIEEEE 1241
Cdd:pfam17380  332 QAAIYAEQERMAMERERElERIRQEERKRELERIRQEEIAMEISRMReleRLQMERQQKNERVRQELeaarkVKILEEER 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1242 ARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLR-EELESQQKAE--RASLEQKNRQMLEQLKEEIEASEKSE 1318
Cdd:pfam17380  412 QRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRlEEQERQQQVErlRQQEEERKRKKLELEKEKRDRKRAEE 491

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1319 QAALNAAKEKALQQlREQLEGERKEAVatLEKEhsaelerlcssLEAKHREVVSSLQKKIQEAQQKEEAQLQKclgqvEH 1398
Cdd:pfam17380  492 QRRKILEKELEERK-QAMIEEERKRKL--LEKE-----------MEERQKAIYEEERRREAEEERRKQQEMEE-----RR 552

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1034572500 1399 RVHQKSYHVAGYEHELSSLLREK---RQEVEGEHERR 1432
Cdd:pfam17380  553 RIQEQMRKATEERSRLEAMERERemmRQIVESEKARA 589
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 59-89 7.04e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 44.44  E-value: 7.04e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034572500   59 PGEWKPCQDITGDIYYFNFANGQSMWDHPCD 89
Cdd:cd00201      1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1271-1667 8.65e-06

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 50.68  E-value: 8.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1271 RAEQEASLQKLREEL--ESQQKAERASLEQKNRQMLEQLKEEIEAS-EKSEQAALNAAKEKALQQLREQLEGERKEAVAT 1347
Cdd:COG5278     85 RAEIDELLAELRSLTadNPEQQARLDELEALIDQWLAELEQVIALRrAGGLEAALALVRSGEGKALMDEIRARLLLLALA 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1348 LEKEHSAELERLcsSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG 1427
Cdd:COG5278    165 LAALLLAAAALL--LLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALAL 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1428 EHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQ 1507
Cdd:COG5278    243 ALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAAA 322

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1508 DLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQ 1587
Cdd:COG5278    323 AALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIAAAAAAA 402

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1588 ARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQS 1667
Cdd:COG5278    403 AAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALAALAAAAA 482
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1256-1391 8.73e-06

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 50.19  E-value: 8.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1256 RAQVQSSTQADEDQIR--AEQEASLQKLREELESQQKAERAslEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKAlqql 1333
Cdd:PRK09510    80 QRKKKEQQQAEELQQKqaAEQERLKQLEKERLAAQEQKKQA--EEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEA---- 153

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034572500 1334 rEQLEGERKEAVATLEKEHSAELERLCSSlEAKHREVVSSLQKKIQEAQQKEEAQLQK 1391
Cdd:PRK09510   154 -KRAAAAAKKAAAEAKKKAEAEAAKKAAA-EAKKKAEAEAAAKAAAEAKKKAEAEAKK 209
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1455-1596 1.05e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.77  E-value: 1.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1455 ERKQRAELLGHLTGELERLqrahERELETVRqeqhKRLEDLRRRHREQERKLQDLELDLET---RAKDVKARLAL----- 1526
Cdd:COG1579     18 ELDRLEHRLKELPAELAEL----EDELAALE----ARLEAAKTELEDLEKEIKRLELEIEEveaRIKKYEEQLGNvrnnk 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034572500 1527 ----LEVQEETARREKQQL----LDVQRQVALKSEEATATHQQLEEAQKEHTHLLqsnQQLREILDELQARKLKLESQ 1596
Cdd:COG1579     90 eyeaLQKEIESLKRRISDLedeiLELMERIEELEEELAELEAELAELEAELEEKK---AELDEELAELEAELEELEAE 164
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1344-1589 1.06e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1344 AVATLEKEHSAELERLcssleakhREVVSSLQKKIQEaQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSL---LRE 1420
Cdd:COG4942     17 AQADAAAEAEAELEQL--------QQEIAELEKELAA-LKKEEKALLKQLAALERRIAALARRIRALEQELAALeaeLAE 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1421 KRQEVEgEHERRLDKMKEEHQQVMAKAreqyEAEERKQRAELLGHLTGELERLQRAheRELETVRQEQHKRLEDLRRrhr 1500
Cdd:COG4942     88 LEKEIA-ELRAELEAQKEELAELLRAL----YRLGRQPPLALLLSPEDFLDAVRRL--QYLKYLAPARREQAEELRA--- 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1501 eqerKLQDLElDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEeatathQQLEEAQKEHTHLLQSNQQLR 1580
Cdd:COG4942    158 ----DLAELA-ALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLE------KELAELAAELAELQQEAEELE 226


                   ....*....
gi 1034572500 1581 EILDELQAR 1589
Cdd:COG4942    227 ALIARLEAE 235
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1252-1620 1.37e-05

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 50.44  E-value: 1.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1252 LSWLRAQ-VQSSTQADEDQIRAE-QEASLQKlreeleSQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAakEKA 1329
Cdd:PRK10929     9 MAWLLSWgAYAATAPDEKQITQElEQAKAAK------TPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNF--PKL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1330 LQQLREQLEGERKE--------AVATLEKE------HSAELERLCSSLEAKHREVVSSLQkkiQEAQQKEEAqlQKCLGQ 1395
Cdd:PRK10929    81 SAELRQQLNNERDEprsvppnmSTDALEQEilqvssQLLEKSRQAQQEQDRAREISDSLS---QLPQQQTEA--RRQLNE 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1396 VEHRVH-------------------QKSYHVAGY-EHELSSLLREKRQEVEgehERRLDKMKEEHQQVMAK--------- 1446
Cdd:PRK10929   156 IERRLQtlgtpntplaqaqltalqaESAALKALVdELELAQLSANNRQELA---RLRSELAKKRSQQLDAYlqalrnqln 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1447 AREQYEAEERKQRAELLGHLTGEL-----ERLQRahERELETVRQEQHKRLEDLRRRHReqerklqdleldlETRAKDVK 1521
Cdd:PRK10929   233 SQRQREAERALESTELLAEQSGDLpksivAQFKI--NRELSQALNQQAQRMDLIASQQR-------------QAASQTLQ 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1522 ARLALlevqeeTARREKQQLLDVQRQV--ALKSEEAtathqQLEEAQKEhthllqsnQQLREILDELQARKLKLESQVDL 1599
Cdd:PRK10929   298 VRQAL------NTLREQSQWLGVSNALgeALRAQVA-----RLPEMPKP--------QQLDTEMAQLRVQRLRYEDLLNK 358

                          410       420
                   ....*....|....*....|.
gi 1034572500 1600 LQAQSQQLQKHFSSLEAEAQK 1620
Cdd:PRK10929   359 QPQLRQIRQADGQPLTAEQNR 379
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1252-1550 1.45e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.52  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1252 LSWLRAQVQSSTQADEDQIRAEqeasLQKLREELESQQK---AERASLEQKNRQmLEQLKEEIEASEKSEQAALN--AAK 1326
Cdd:COG4372     25 LIAALSEQLRKALFELDKLQEE----LEQLREELEQAREeleQLEEELEQARSE-LEQLEEELEELNEQLQAAQAelAQA 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1327 EKALQQLREQLEGERKEaVATLEKEhSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEE--AQLQKCLGQVEHRVHQKS 1404
Cdd:COG4372    100 QEELESLQEEAEELQEE-LEELQKE-RQDLEQQRKQLEAQIAELQSEIAEREEELKELEEqlESLQEELAALEQELQALS 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1405 yhVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETV 1484
Cdd:COG4372    178 --EAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEV 255

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1485 RQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVAL 1550
Cdd:COG4372    256 ILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAAL 321
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 1140-1428 1.47e-05

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 50.24  E-value: 1.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1140 DPEEKVAVSPTPPVSPEVRSTEPVAP--PEQLSEA----------ALKAMEEAVAQVLEQDQRHLLESK--QEKMQQLRE 1205
Cdd:PLN03229   414 DPERKVNMKKREAVKTPVRELEGEVEklKEQILKAkessskpselALNEMIEKLKKEIDLEYTEAVIAMglQERLENLRE 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1206 KLCQEEEE----------EILRLHQQKEQSLS------SLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDq 1269
Cdd:PLN03229   494 EFSKANSQdqlmhpvlmeKIEKLKDEFNKRLSrapnylSLKYKLDMLNEFSRAKALSEKKSKAEKLKAEINKKFKEVMD- 572

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1270 iRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASE----KSEQAALNAAKEKALQQLREQLEGERKEAV 1345
Cdd:PLN03229   573 -RPEIKEKMEALKAEVASSGASSGDELDDDLKEKVEKMKKEIELELagvlKSMGLEVIGVTKKNKDTAEQTPPPNLQEKI 651

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1346 ATLEKEHSAELERLCSSLEAKHRevVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGyehelSSLLREKRQEV 1425
Cdd:PLN03229   652 ESLNEEINKKIERVIRSSDLKSK--IELLKLEVAKASKTPDVTEKEKIEALEQQIKQKIAEALN-----SSELKEKFEEL 724


                   ...
gi 1034572500 1426 EGE 1428
Cdd:PLN03229   725 EAE 727
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 823-1190 1.50e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 1.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  823 SQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLSSAvgkgRQGSGARPGLPEKEENEKSEPKicRNLVTPKADPTGSEPA 902
Cdd:PHA03307    45 SDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAP----ANESRSTPTWSLSTLAPASPAR--EGSPTPPGPSSPDPPP 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  903 KASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQEleiSEHMKEPQLSDSIASDPKSFHGL-----DFGF 977
Cdd:PHA03307   119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA---SDAASSRQAALPLSSPEETARAPssppaEPPP 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  978 RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEESSLPALQMEGPDSAALPGLTRLSPPl 1057
Cdd:PHA03307   196 STPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASG- 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1058 PHEERAQSPPRSlatEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSqaeeLGPGQEE 1137
Cdd:PHA03307   275 WNGPSSRPGPAS---SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA----VSPGPSP 347

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1138 AEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQR 1190
Cdd:PHA03307   348 SRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARR 400
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 58-87 1.73e-05

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 43.26  E-value: 1.73e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1034572500   58 LPGEWKPCQDITGDIYYFNFANGQSMWDHP 87
Cdd:pfam00397    1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1454-1661 1.80e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.13  E-value: 1.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1454 EERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEET 1533
Cdd:COG4372      9 GKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQ 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1534 ARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSS 1613
Cdd:COG4372     89 LQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAA 168

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1614 LEAEAQ-----KKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVS 1661
Cdd:COG4372    169 LEQELQalseaEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELL 221
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1143-1539 2.54e-05

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 49.37  E-value: 2.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1143 EKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLcqeeeeeilrlhQQK 1222
Cdd:pfam09731   99 SEVAEEEKEATKDAAEAKAQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHT------------DSL 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1223 EQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIrAEQEASLQKLREELESQQKAERAslEQKNRQ 1302
Cdd:pfam09731  167 KEASDTAEISREKATDSALQKAEALAEKLKEVINLAKQSEEEAAPPLL-DAAPETPPKLPEHLDNVEEKVEK--AQSLAK 243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1303 MLEQLKEEIEASEkseqaalnaakekalQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVvSSLQKKIQEAQ 1382
Cdd:pfam09731  244 LVDQYKELVASER---------------IVFQQELVSIFPDIIPVLKEDNLLSNDDLNSLIAHAHREI-DQLSKKLAELK 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1383 QKEEAQLQKCLGQVEHrvhqksyhvagyehELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEerkqrael 1462
Cdd:pfam09731  308 KREEKHIERALEKQKE--------------ELDKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYEEK-------- 365

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1463 lghLTGELERLQRAHERELETVRQEQHkrlEDLRRRHR-------EQERKLQDLELD-LETRAKDVKARLALLEVQEETA 1534
Cdd:pfam09731  366 ---LRTELERQAEAHEEHLKDVLVEQE---IELQREFLqdikekvEEERAGRLLKLNeLLANLKGLEKATSSHSEVEDEN 439


                   ....*
gi 1034572500 1535 RREKQ 1539
Cdd:pfam09731  440 RKAQQ 444
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1185-1789 2.73e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 49.58  E-value: 2.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1185 LEQDQRHLLESKQEKMQQLREKLCQEEEEEILRL-HQQKEQSLSSLRERLQKA-IEEEEARMREEESQRLSWLRAQVQSS 1262
Cdd:pfam02463  234 LNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLaQVLKENKEEEKEKKLQEEeLKLLAKEEEELKSELLKLERRKVDDE 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1263 TQADEDQIRAEQEASLQKLREELESQQKAERASLEqknRQMLEQLKEEIEASEKSEQAALNAAKEKALQQL-REQLEGER 1341
Cdd:pfam02463  314 EKLKESEKEKKKAEKELKKEKEEIEELEKELKELE---IKREAEEEEEEELEKLQEKLEQLEEELLAKKKLeSERLSSAA 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1342 KEAVATLEKEHSAELERlcsSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREK 1421
Cdd:pfam02463  391 KLKEEELELKSEEEKEA---QLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELEL 467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1422 RQE-----------VEGEHERRLDKMKEEHQQVMA-KAREQYEAEERKQRAELLGHLTGELERLQRAHERE--------- 1480
Cdd:pfam02463  468 KKSedllketqlvkLQEQLELLLSRQKLEERSQKEsKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVenykvaist 547

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1481 LETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE--ETARREKQQLLDVQRQVALKSEEATAT 1558
Cdd:pfam02463  548 AVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEidPILNLAQLDKATLEADEDDKRAKVVEG 627

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1559 HQQLEEAQKEHTHLLQSNQQLREI--LDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNAS 1636
Cdd:pfam02463  628 ILKDTELTKLKESAKAKESGLRKGvsLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQR 707

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1637 PHFEP-DLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSA-EGVALRSAKEFLVQQTRSMRRRQTALK 1714
Cdd:pfam02463  708 EKEELkKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKeEKEEEKSELSLKEKELAEEREKTEKLK 787

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034572500 1715 AAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDE 1789
Cdd:pfam02463  788 VEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEE 862
PRK11637 PRK11637
AmiB activator; Provisional
 1172-1384 2.74e-05

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 48.92  E-value: 2.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1172 AALKAMEEAVAQVLEQdqrhlLESKQEKMQQLrEKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMRE----- 1246
Cdd:PRK11637    75 AQLKKQEEAISQASRK-----LRETQNTLNQL-NKQIDELNASIAKLEQQQAAQERLLAAQLDAAFRQGEHTGLQlilsg 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1247 EESQRLSWLRAQVQSSTQADEDQIraeqeASLQKLREELeSQQKAErasLEQKNRQMLEQLKEEIEASEKSEQA------ 1320
Cdd:PRK11637   149 EESQRGERILAYFGYLNQARQETI-----AELKQTREEL-AAQKAE---LEEKQSQQKTLLYEQQAQQQKLEQArnerkk 219

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572500 1321 ---ALNAAKEKALQQLRE--QLEGERKEAVATLEKEHSAELERlcsslEAKHREVVsslQKKIQEAQQK 1384
Cdd:PRK11637   220 tltGLESSLQKDQQQLSElrANESRLRDSIARAEREAKARAER-----EAREAARV---RDKQKQAKRK 280
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1251-1782 2.91e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.25  E-value: 2.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 RLSWLRAQVQSSTQADEDQIR--AEQEASLQKLREELESQQKA------ERASLEQKnrqmLEQLKEEIEaSEKSEQAAL 1322
Cdd:TIGR04523  146 EIKKKEKELEKLNNKYNDLKKqkEELENELNLLEKEKLNIQKNidkiknKLLKLELL----LSNLKKKIQ-KNKSLESQI 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1323 NAAKEKAlQQLREQLEGERKEAVATLEKEHSAElERLcSSLEAKHREVVSSLQKKIQEAQQKEeaqlqKCLGQVEHRVHQ 1402
Cdd:TIGR04523  221 SELKKQN-NQLKDNIEKKQQEINEKTTEISNTQ-TQL-NQLKDEQNKIKKQLSEKQKELEQNN-----KKIKELEKQLNQ 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1403 ksyhvagYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEA-----EERKQRAELLGHLTGELERLQRah 1477
Cdd:TIGR04523  293 -------LKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIisqlnEQISQLKKELTNSESENSEKQR-- 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1478 erELEtvrqEQHKRLEDLRRrhrEQERKLQDLElDLETRAKDVKARLallEVQEETARREKQQLLDVQRQVALKSEEATA 1557
Cdd:TIGR04523  364 --ELE----EKQNEIEKLKK---ENQSYKQEIK-NLESQINDLESKI---QNQEKLNQQKDEQIKKLQQEKELLEKEIER 430

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1558 THQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVT-----VEE 1632
Cdd:TIGR04523  431 LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNeekkeLEE 510

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1633 NNASPHFEPDLHIEDLRKSlgTNQTKEVSSSLSQSKEDLylDSLSSHNVWHLLsaEGVALRSAKEfLVQqtrsMRRRQTA 1712
Cdd:TIGR04523  511 KVKDLTKKISSLKEKIEKL--ESEKKEKESKISDLEDEL--NKDDFELKKENL--EKEIDEKNKE-IEE----LKQTQKS 579

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1713 LKAAQQHwrhelasAQEVAKDppgikaLEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSL 1782
Cdd:TIGR04523  580 LKKKQEE-------KQELIDQ------KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNI 636
mukB PRK04863
chromosome partition protein MukB;
1188-1627 3.40e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.19  E-value: 3.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1188 DQRHLLESKQEKMQQLREklcqeeeeeiLRLHQQKEQSLSSLRERLQKaieeeearmreeesqrlswlRAQVQSSTQADE 1267
Cdd:PRK04863   507 EQRHLAEQLQQLRMRLSE----------LEQRLRQQQRAERLLAEFCK--------------------RLGKNLDDEDEL 556

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1268 DQIRAEQEASLQKLREELESQqkAERASLEqknRQMLEQLKEEIEASEKSEQAALNAakEKALQQLREQLEGERKEAVA- 1346
Cdd:PRK04863   557 EQLQEELEARLESLSESVSEA--RERRMAL---RQQLEQLQARIQRLAARAPAWLAA--QDALARLREQSGEEFEDSQDv 629

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1347 ------TLEKEHSAELERlcSSLEAKHRevvsSLQKKIQEAQQKEEAQLQKCLGQVEH-------------RVHQKSYHV 1407
Cdd:PRK04863   630 teymqqLLERERELTVER--DELAARKQ----ALDEEIERLSQPGGSEDPRLNALAERfggvllseiyddvSLEDAPYFS 703

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1408 AGY--------------------------------EHELSSLlREKRQEVE----------GEHERRLDKMKEEhqQVMA 1445
Cdd:PRK04863   704 ALYgparhaivvpdlsdaaeqlagledcpedlyliEGDPDSF-DDSVFSVEelekavvvkiADRQWRYSRFPEV--PLFG 780

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1446 K-AREQYEAE---ERKQRAELLGHLTGELERLQRAHERELETVRQ--------EQHKRLEDLRRRHREQERKLQDLE--- 1510
Cdd:PRK04863   781 RaAREKRIEQlraEREELAERYATLSFDVQKLQRLHQAFSRFIGShlavafeaDPEAELRQLNRRRVELERALADHEsqe 860

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1511 LDLETRAKDVKARLALL--------------------EVQEETARRE--------------------------------- 1537
Cdd:PRK04863   861 QQQRSQLEQAKEGLSALnrllprlnlladetladrveEIREQLDEAEeakrfvqqhgnalaqlepivsvlqsdpeqfeql 940

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1538 -------KQQLLDVQRQV-ALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQK 1609
Cdd:PRK04863   941 kqdyqqaQQTQRDAKQQAfALTEVVQRRAHFSYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQ 1020

                          570
                   ....*....|....*...
gi 1034572500 1610 HFSSLEAEAQKKQHLLRE 1627
Cdd:PRK04863  1021 VLASLKSSYDAKRQMLQE 1038
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1167-1494 3.43e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.28  E-value: 3.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1167 EQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAieEEEARMRE 1246
Cdd:TIGR02168  704 RKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEA--EEELAEAE 781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1247 EESQRLSWLRAQVQSSTQADEDQIRAEQEA------SLQKLREELESQQKAERAS------LEQKNRQMLEQLkEEIEAS 1314
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAEltllneEAANLRERLESLERRIAATerrledLEEQIEELSEDI-ESLAAE 860

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1315 EKSEQAALNAAKE--KALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEAKhREVVSSLQKKIQEAQQKEE 1386
Cdd:TIGR02168  861 IEELEELIEELESelEALLNERASLEEALALLRSELEElseelrELESKRSELRRELEEL-REKLAQLELRLEGLEVRID 939

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1387 AQLQKC--LGQVEHRVHQKSYhvagyehelssllrEKRQEVEGEHERRLDKMKEEHQQ---VMAKAREQYEAEErkqraE 1461
Cdd:TIGR02168  940 NLQERLseEYSLTLEEAEALE--------------NKIEDDEEEARRRLKRLENKIKElgpVNLAAIEEYEELK-----E 1000

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1034572500 1462 LLGHLTGELERLQRAHERELETVRQ---EQHKRLED 1494
Cdd:TIGR02168 1001 RYDFLTAQKEDLTEAKETLEEAIEEidrEARERFKD 1036
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1284-1590 3.45e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 48.98  E-value: 3.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1284 ELESQQKAERASLEQKNRQMLEqLKEEIeASEKSEQAALnaakEKALQQLREQLEGERKEAVA-TLEKEHSAELERL--- 1359
Cdd:pfam07111  321 QLKAQDLEHRDSVKQLRGQVAE-LQEQV-TSQSQEQAIL----QRALQDKAAEVEVERMSAKGlQMELSRAQEARRRqqq 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1360 -CSSLEAKHREVVSSLqKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYeHELSSLLREK------RQE-------- 1424
Cdd:pfam07111  395 qTASAEEQLKFVVNAM-SSTQIWLETTMTRVEQAVARIPSLSNRLSYAVRKV-HTIKGLMARKvalaqlRQEscpppppa 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1425 --VEGEHERRLDKMKEEH--------------QQVMAKAREQYEAEeRKQRAELLGHLTGELERLQRAHE---RELETVR 1485
Cdd:pfam07111  473 ppVDADLSLELEQLREERnrldaelqlsahliQQEVGRAREQGEAE-RQQLSEVAQQLEQELQRAQESLAsvgQQLEVAR 551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1486 QEQHKRLED---LRRRHREQE----RKLQDLELDLETRAKDvkaRLALLEVQEETARREKQQLLDVQRQVALKSEEATAT 1558
Cdd:pfam07111  552 QGQQESTEEaasLRQELTQQQeiygQALQEKVAEVETRLRE---QLSDTKRRLNEARREQAKAVVSLRQIQHRATQEKER 628

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1034572500 1559 HQQLEEAQKEHTHllQSNQQLREILDELQARK 1590
Cdd:pfam07111  629 NQELRRLQDEARK--EEGQRLARRVQELERDK 658
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1285-1566 3.70e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.86  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1285 LESQQKAERASLEQKNRQMLEQLKEeieASEKSEQAalnaakEKALQQLREQlegerkEAVATLEKEHSAELERLcSSLE 1364
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQLPE---LRKELEEA------EAALEEFRQK------NGLVDLSEEAKLLLQQL-SELE 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1365 AKHREvvssLQKKIQEAQQKEEaQLQKCLGQVEHRVHQKSyhvagyEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVM 1444
Cdd:COG3206    226 SQLAE----ARAELAEAEARLA-ALRAQLGSGPDALPELL------QSPVIQQLRAQLAELEAELAELSARYTPNHPDVI 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1445 AKareqyeaeeRKQRAELLGHLTGELERLQRAHERELETVRQeqhkRLEDLRRRHREQERKLQDLeldletrakdvkarl 1524
Cdd:COG3206    295 AL---------RAQIAALRAQLQQEAQRILASLEAELEALQA----REASLQAQLAQLEARLAEL--------------- 346

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1034572500 1525 allevqeetARREkQQLLDVQRQVALKSEEATATHQQLEEAQ 1566
Cdd:COG3206    347 ---------PELE-AELRRLEREVEVARELYESLLQRLEEAR 378
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1261-1461 3.86e-05

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 48.79  E-value: 3.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1261 SSTQADEDQIRAEQeASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGE 1340
Cdd:pfam15709  329 EQEKASRDRLRAER-AEMRRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQRQEEEE 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1341 RKEAVatlekEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQkclgqvehrvhqksyhvagyehelssllRE 1420
Cdd:pfam15709  408 RKQRL-----QLQAAQERARQQQEEFRRKLQELQRKKQQEEAERAEAEKQ----------------------------RQ 454

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1034572500 1421 KRQEVE-GEHERRLDKMKEEH------QQVMAKAREQYEAEERKQRAE 1461
Cdd:pfam15709  455 KELEMQlAEEQKRLMEMAEEErleyqrQKQEAEEKARLEAEERRQKEE 502
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1118-1473 4.04e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.81  E-value: 4.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1118 CEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQ 1197
Cdd:TIGR00618  530 MQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDM 609

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1198 ---EKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQ 1274
Cdd:TIGR00618  610 lacEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEK 689

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1275 EaSLQKLREELESQQKAERaSLEQKNRQmLEQLKEEIEASEKSEQAALNaAKEKALQQLREQLEGERKEAVATLEKEHsa 1354
Cdd:TIGR00618  690 E-QLTYWKEMLAQCQTLLR-ELETHIEE-YDREFNEIENASSSLGSDLA-AREDALNQSLKELMHQARTVLKARTEAH-- 763

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1355 elerlcsslEAKHREVVSSLQKKIQEAQQKEEAQLQKclGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVE---GEHER 1431
Cdd:TIGR00618  764 ---------FNNNEEVTAALQTGAELSHLAAEIQFFN--RLREEDTHLLKTLEAEIGQEIPSDEDILNLQCEtlvQEEEQ 832

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1034572500 1432 RLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERL 1473
Cdd:TIGR00618  833 FLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQL 874
Filament pfam00038
Intermediate filament protein;
1268-1556 4.19e-05

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 47.99  E-value: 4.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1268 DQIRA--EQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKsEQAALNAAKEKA---LQQLREQLE---G 1339
Cdd:pfam00038   18 DKVRFleQQNKLLETKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTV-ERARLQLELDNLrlaAEDFRQKYEdelN 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1340 ERKEA---VATLEKE-HSAELERLcssleakhrevvsSLQKKIQEAQqkEEAQLQKCLGQVEHRvhqksyhvagyehELS 1415
Cdd:pfam00038   97 LRTSAendLVGLRKDlDEATLARV-------------DLEAKIESLK--EELAFLKKNHEEEVR-------------ELQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1416 SLLREKRQEVEGEHERRLDKmkeehQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKrLEDL 1495
Cdd:pfam00038  149 AQVSDTQVNVEMDAARKLDL-----TSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEE-ITEL 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1496 RRR----------HREQ----ERKLQDLELDLETRAKDVKARLALLEVQ-----EETAR--REKQQLLDVqrQVALKSEE 1554
Cdd:pfam00038  223 RRTiqsleielqsLKKQkaslERQLAETEERYELQLADYQELISELEAElqetrQEMARqlREYQELLNV--KLALDIEI 300


                   ..
gi 1034572500 1555 AT 1556
Cdd:pfam00038  301 AT 302
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 1264-1336 4.23e-05

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 45.55  E-value: 4.23e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1264 QADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ 1336
Cdd:COG0711     47 KEEAEAALAEYEEKLAEARAEAAEIIAEARKEAEAIAEEAKAEAEAEAERIIAQAEAEIEQERAKALAELRAE 119
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 57-87 4.31e-05

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 42.20  E-value: 4.31e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1034572500    57 PLPGEWKPCQDITGDIYYFNFANGQSMWDHP 87
Cdd:smart00456    1 PLPPGWEERKDPDGRPYYYNHETKETQWEKP 31
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
1268-1387 4.91e-05

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 46.74  E-value: 4.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1268 DQIRAEQEASLQKLREELeSQQKAERASLEQKnrqmLEQLKEEIEASEKSEQAALNAAKE----KALQQlREQLEGERKE 1343
Cdd:COG1842     29 DQAIRDMEEDLVEARQAL-AQVIANQKRLERQ----LEELEAEAEKWEEKARLALEKGREdlarEALER-KAELEAQAEA 102

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1034572500 1344 AVATLEkEHSAELERLcssleakhREVVSSLQKKIQEAQQKEEA 1387
Cdd:COG1842    103 LEAQLA-QLEEQVEKL--------KEALRQLESKLEELKAKKDT 137
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1250-1620 6.78e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 48.19  E-value: 6.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1250 QRLSWLRAQVQSSTQADEDQiraeQEASLQKLREELE--SQQKAERASLEQKNRQMLEQL---KEEIEASEK--SEQAAL 1322
Cdd:pfam15921  429 QRLEALLKAMKSECQGQMER----QMAAIQGKNESLEkvSSLTAQLESTKEMLRKVVEELtakKMTLESSERtvSDLTAS 504

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1323 NAAKEKALQQLREQLEGERKEAVATL--------EKEHSAELERLCSSLE---AKHREVVSSLQKKIQE----------- 1380
Cdd:pfam15921  505 LQEKERAIEATNAEITKLRSRVDLKLqelqhlknEGDHLRNVQTECEALKlqmAEKDKVIEILRQQIENmtqlvgqhgrt 584

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1381 --AQQKEEAQLQKCLGqvEHRVHQKSYHVagyehelsslLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEA--EER 1456
Cdd:pfam15921  585 agAMQVEKAQLEKEIN--DRRLELQEFKI----------LKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAvkDIK 652

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1457 KQRAELLGHLtgelerlqRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARR 1536
Cdd:pfam15921  653 QERDQLLNEV--------KTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGH 724

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1537 EKQQLLDVQRQVALKSEEATATH---QQLEE----AQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQK 1609
Cdd:pfam15921  725 AMKVAMGMQKQITAKRGQIDALQskiQFLEEamtnANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804

                          410
                   ....*....|.
gi 1034572500 1610 HFSSLEAEAQK 1620
Cdd:pfam15921  805 KVANMEVALDK 815
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1188-1547 6.95e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.89  E-value: 6.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1188 DQRHLLESKQEKMQQLREKlcqeeeeeILRLHQQ---KEQSLSSLRERLQKaieeeearmreeesqrlswlrAQVQSSTQ 1264
Cdd:pfam10174  384 DLKDMLDVKERKINVLQKK--------IENLQEQlrdKDKQLAGLKERVKS---------------------LQTDSSNT 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1265 ----ADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQmLEQLKEEIEAS--EKSEQ-AALNAAKEKA-------- 1329
Cdd:pfam10174  435 dtalTTLEEALSEKERIIERLKEQREREDRERLEELESLKKE-NKDLKEKVSALqpELTEKeSSLIDLKEHAsslassgl 513

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1330 -----LQQLREQLEGERKEAVAT---LEKEHSAEL-ERLCSSLEAKHREVVSSLQKKIQEAQ--QKEEAQLQKCLGQVEH 1398
Cdd:pfam10174  514 kkdskLKSLEIAVEQKKEECSKLenqLKKAHNAEEaVRTNPEINDRIRLLEQEVARYKEESGkaQAEVERLLGILREVEN 593

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1399 RVHQKSYHVAgyEHELSSLLREKRQEVEGEHERRLDK-MKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERL---- 1473
Cdd:pfam10174  594 EKNDKDKKIA--ELESLTLRQMKEQNKKVANIKHGQQeMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTrqel 671

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1474 -----------QRAHERE--LETVRQEqhkrledlRRRHREQERKLQDLELDLETRAKDvkARLALLEV--------QEE 1532
Cdd:pfam10174  672 datkarlsstqQSLAEKDghLTNLRAE--------RRKQLEEILEMKQEALLAAISEKD--ANIALLELssskkkktQEE 741

                          410
                   ....*....|....*..
gi 1034572500 1533 TA--RREKQQLLDVQRQ 1547
Cdd:pfam10174  742 VMalKREKDRLVHQLKQ 758
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1268-1461 7.61e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 48.29  E-value: 7.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1268 DQIRAEQEASLQ--KLREELESQQKAERASLEQK----NRQMLEQLKEEIEASEKSEQAALNAAKEKAL----QQLREQL 1337
Cdd:NF012221  1532 DNVVATSESSQQadAVSKHAKQDDAAQNALADKEraeaDRQRLEQEKQQQLAAISGSQSQLESTDQNALetngQAQRDAI 1611

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1338 EGERKEAVATLEK------------EHSAEL---------ERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQkclgQV 1396
Cdd:NF012221  1612 LEESRAVTKELTTlaqgldaldsqaTYAGESgdqwrnpfaGGLLDRVQEQLDDAKKISGKQLADAKQRHVDNQQ----KV 1687

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1397 EHRVHQKSYHVA-GYEHELSSLLREKRQEVEGEhERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 1461
Cdd:NF012221  1688 KDAVAKSEAGVAqGEQNQANAEQDIDDAKADAE-KRKDDALAKQNEAQQAESDANAAANDAQSRGE 1752
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1441-1570 7.82e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 47.90  E-value: 7.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1441 QQVMAKAREQYEAEERK-----QRAEllghltgELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLEt 1515
Cdd:PRK00409   501 ENIIEEAKKLIGEDKEKlneliASLE-------ELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAE- 572

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1516 rakdVKARLALLEVQEETARREKQ-QLLDVQRQVALKSEEATATHQQLEEAQKEHT 1570
Cdd:PRK00409   573 ----KEAQQAIKEAKKEADEIIKElRQLQKGGYASVKAHELIEARKRLNKANEKKE 624
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1252-1778 8.67e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.51  E-value: 8.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1252 LSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQqkaerasLEQKNRQMLeQLKEEIEaseKSEQAALNAAKEKALQ 1331
Cdd:pfam10174  164 LEMLQSKGLPKKSGEEDWERTRRIAEAEMQLGHLEVL-------LDQKEKENI-HLREELH---RRNQLQPDPAKTKALQ 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1332 QLREQLE---GERKEAVATLEKE-----HSAELERLCSSLEAKHREVVSSLQK----KIQEAQQ---KEEAQLQKCLGQV 1396
Cdd:pfam10174  233 TVIEMKDtkiSSLERNIRDLEDEvqmlkTNGLLHTEDREEEIKQMEVYKSHSKfmknKIDQLKQelsKKESELLALQTKL 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1397 EHRVHQKS---YHVAGYEHELSSllREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYE--AEERkqraellGHLTGELE 1471
Cdd:pfam10174  313 ETLTNQNSdckQHIEVLKESLTA--KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQdlTEEK-------STLAGEIR 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1472 RLQR---AHERELETVrqeqHKRLEDLRRRHREQERKLQDLE---LDLETRAKDVKARLALLEvqeeTARREKQQLLDvq 1545
Cdd:pfam10174  384 DLKDmldVKERKINVL----QKKIENLQEQLRDKDKQLAGLKervKSLQTDSSNTDTALTTLE----EALSEKERIIE-- 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1546 rqvALKSEEATATHQQLEEAQKehthLLQSNQQLREILDELQARKLKLES-------QVDLLQAQSQQLQKHFSSLEAEA 1618
Cdd:pfam10174  454 ---RLKEQREREDRERLEELES----LKKENKDLKEKVSALQPELTEKESslidlkeHASSLASSGLKKDSKLKSLEIAV 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1619 QKK---------QHLLREVTVEENNASPHFepDLHIEDLRKSLGTNQTKevsSSLSQSKEDLYLDSLSSHNVWHLLSAEG 1689
Cdd:pfam10174  527 EQKkeecsklenQLKKAHNAEEAVRTNPEI--NDRIRLLEQEVARYKEE---SGKAQAEVERLLGILREVENEKNDKDKK 601

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1690 VAlrSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS-------AQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMR 1762
Cdd:pfam10174  602 IA--ELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQlleearrREDNLADNSQQLQLEELMGALEKTRQELDATKARLS 679

                          570
                   ....*....|....*.
gi 1034572500 1763 KGHNLLKKKEEKLNQL 1778
Cdd:pfam10174  680 STQQSLAEKDGHLTNL 695
mukB PRK04863
chromosome partition protein MukB;
1255-1598 9.82e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.64  E-value: 9.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1255 LRAQVQSStqadEDQIRAEQEAsLQKLREELEsQQKAERASLEQKNRQMLEQLKEEIEA---SEKSEQAalnaakEKALQ 1331
Cdd:PRK04863   291 LRRELYTS----RRQLAAEQYR-LVEMARELA-ELNEAESDLEQDYQAASDHLNLVQTAlrqQEKIERY------QADLE 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1332 QLREQLEgERKEAVAtLEKEHSAELERLCSSLEakhrEVVSSLQKKIQEAQQKEEAQlQKCLGQVEHRVH-----QKSYH 1406
Cdd:PRK04863   359 ELEERLE-EQNEVVE-EADEQQEENEARAEAAE----EEVDELKSQLADYQQALDVQ-QTRAIQYQQAVQaleraKQLCG 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1407 VAGYEHE-LSSLLREKRQEVEGEHERRLDKmkeEHQQVMAK-AREQYEaeerkQRAELLGHLTGELERlQRAHERELETV 1484
Cdd:PRK04863   432 LPDLTADnAEDWLEEFQAKEQEATEELLSL---EQKLSVAQaAHSQFE-----QAYQLVRKIAGEVSR-SEAWDVARELL 502

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1485 RQ-EQHK----RLEDLRRRHREQERKLQdLELDLETRAKDVKARLAL-----LEVQEETARREkQQLLDVQRQVALKSEE 1554
Cdd:PRK04863   503 RRlREQRhlaeQLQQLRMRLSELEQRLR-QQQRAERLLAEFCKRLGKnlddeDELEQLQEELE-ARLESLSESVSEARER 580

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1034572500 1555 ATATHQQLEEaqkehthllqsnqqlreildelqarklkLESQVD 1598
Cdd:PRK04863   581 RMALRQQLEQ----------------------------LQARIQ 596
COG4995 COG4995
Uncharacterized conserved protein, contains CHAT domain [Function unknown];
1180-1597 1.08e-04

Uncharacterized conserved protein, contains CHAT domain [Function unknown];


Pssm-ID: 444019 [Multi-domain]  Cd Length: 711  Bit Score: 47.27  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1180 AVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQV 1259
Cdd:COG4995     12 ALLAALALALLALALLLLLAALAAAALLLLALLALLLALAAAAAAALAAAALALALLAAAALALLLLALALAALALALLA 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1260 QSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAkEKALQQLREQLEG 1339
Cdd:COG4995     92 AALALALAAAALAALALLAALLALAAAAALLALLAALALLALLAALAAALAAAAAAALAAALAAAA-AAAAAAALLALAL 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1340 ERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 1419
Cdd:COG4995    171 ALAAAALALLALLLAALAAALAAAAAALALLLALLLLAALAAALAAALAALLLALLALAAALLALLLLALLALAAAAAAL 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1420 EKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELET----VRQEQHKRLEDL 1495
Cdd:COG4995    251 AAAAAALLALAAALLLLAALAALAAAAAAAALAALALAAALALAAAALALALLLAAAAAAALAAlallLLAALLLLLAAL 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1496 RRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQ----VALKSEEATATHQQLEEAQKEHTH 1571
Cdd:COG4995    331 ALLALLLLLAAAALLAAALAAALALAAALALALLAALLLLLAALLALLLEALllllLALLAALLLLAAALLALAAAQLLR 410

                          410       420
                   ....*....|....*....|....*.
gi 1034572500 1572 LLQSNQQLREILDELQARKLKLESQV 1597
Cdd:COG4995    411 LLLAALALLLALAAYAAARLALLALI 436
Caldesmon pfam02029
Caldesmon;
1266-1576 1.23e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 46.78  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1266 DEDQIRAEQEASlQKLREELESQQKAERASLEQKNRQMLEQ---------LKEEIEASEKSEQAALN---AAKEKALQQL 1333
Cdd:pfam02029    1 IEDEEEAARERR-RRAREERRRQKEEEEPSGQVTESVEPNEhnsyeedseLKPSGQGGLDEEEAFLDrtaKREERRQKRL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1334 REQLEGE----------------RKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQlqkclgQVE 1397
Cdd:pfam02029   80 QEALERQkefdptiadekesvaeRKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVR------QAE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1398 HRVHQKSYHVAgyEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAkaREQYEAEERKQRAELLGHLTGELERLQRAH 1477
Cdd:pfam02029  154 EEGEEEEDKSE--EAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLD--QKRGHPEVKSQNGEEEVTKLKVTTKRRQGG 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1478 ERELETVRQEQH------KRLEDLRRRHREQER--------KLQDLELDLETRAKDVKARLALLEvqEETARREKQQLld 1543
Cdd:pfam02029  230 LSQSQEREEEAEvfleaeQKLEELRRRRQEKESeefeklrqKQQEAELELEELKKKREERRKLLE--EEEQRRKQEEA-- 305

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1034572500 1544 vQRQVAlKSEEATATHQQLEEAQKEHTHLLQSN 1576
Cdd:pfam02029  306 -ERKLR-EEEEKRRMKEEIERRRAEAAEKRQKL 336
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1414-1568 1.39e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 46.79  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1414 LSSLLREKRQEV-EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRaellghltgELERLQRAH-ERELETVRQEQHKR 1491
Cdd:COG2268    186 LDALGRRKIAEIiRDARIAEAEAERETEIAIAQANREAEEAELEQER---------EIETARIAEaEAELAKKKAEERRE 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1492 LEDLRRR-----HREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLL--DVQRQVALKSEEATATHQQlEE 1564
Cdd:COG2268    257 AETARAEaeaayEIAEANAEREVQRQLEIAEREREIELQEKEAEREEAELEADVRKpaEAEKQAAEAEAEAEAEAIR-AK 335


                   ....
gi 1034572500 1565 AQKE 1568
Cdd:COG2268    336 GLAE 339
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1374-1545 1.85e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 45.65  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1374 LQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV-AGY------------------------EHELSSLLREKrqEVEGE 1428
Cdd:cd16269    107 CKQNEEASSKRCQALLQELSAPLEEKISQGSYSVpGGYqlyledreklvekyrqvprkgvkaEEVLQEFLQSK--EAEAE 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1429 HERRLDKMKEEHQQVMAKAREQYEAEErkQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQD 1508
Cdd:cd16269    185 AILQADQALTEKEKEIEAERAKAEAAE--QERKLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEEERENLLKEQERALE 262

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1034572500 1509 LELDLETRakdvkarlALLEVQEETARREKQQLLDVQ 1545
Cdd:cd16269    263 SKLKEQEA--------LLEEGFKEQAELLQEEIRSLK 291
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1185-1521 2.01e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.55  E-value: 2.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1185 LEQDQRHLLESKQEKMQQLREKlcQEEEEEILRLHQQKEQSLSSLRERLQKaieeeearmreeesqrlswLRAQVQSSTQ 1264
Cdd:TIGR04523  347 LKKELTNSESENSEKQRELEEK--QNEIEKLKKENQSYKQEIKNLESQIND-------------------LESKIQNQEK 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1265 adEDQIRAEQEASLQKLREELESQQKAERASLEqKNRQMLEQLKEEIEASEKsEQAALNAAKEKALQQLrEQLEGERKEA 1344
Cdd:TIGR04523  406 --LNQQKDEQIKKLQQEKELLEKEIERLKETII-KNNSEIKDLTNQDSVKEL-IIKNLDNTRESLETQL-KVLSRSINKI 480

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1345 VATLEKEhSAELERLCSSLEAKHREV------VSSLQKKIQEAQQKEEaQLQKCLGQVEHRVHQKsyhvagyEHELSS-- 1416
Cdd:TIGR04523  481 KQNLEQK-QKELKSKEKELKKLNEEKkeleekVKDLTKKISSLKEKIE-KLESEKKEKESKISDL-------EDELNKdd 551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1417 --LLREKRQEVEGEHERRLDKMKEEHQQVMAKARE------QYEAEERKQRAELLghltgELERLQRAHERELETVRQEq 1488
Cdd:TIGR04523  552 feLKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEkqelidQKEKEKKDLIKEIE-----EKEKKISSLEKELEKAKKE- 625

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1034572500 1489 HKRLEdlrrrhrEQERKLQDLELDLETRAKDVK 1521
Cdd:TIGR04523  626 NEKLS-------SIIKNIKSKKNKLKQEVKQIK 651
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1365-1541 2.13e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1365 AKHREVVSSLQKKIQEAQQkEEAQLQKCLGQVEHRVHqksyhvagyehELSSLLREKRQEVEgEHERRLDKMKEehQQVM 1444
Cdd:COG1579     20 DRLEHRLKELPAELAELED-ELAALEARLEAAKTELE-----------DLEKEIKRLELEIE-EVEARIKKYEE--QLGN 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1445 AKAREQYEAeerkqraellghLTGELERLQRAHErELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARL 1524
Cdd:COG1579     85 VRNNKEYEA------------LQKEIESLKRRIS-DLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEEL 151

                          170
                   ....*....|....*..
gi 1034572500 1525 ALLEVQEETARREKQQL 1541
Cdd:COG1579    152 AELEAELEELEAEREEL 168
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 1174-1536 2.29e-04

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 45.80  E-value: 2.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1174 LKAMEEAVAQVLEQDQRHLL----ESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKaieeeearMREEES 1249
Cdd:pfam15558   37 LRRRDQKRQETLERERRLLLqqsqEQWQAEKEQRKARLGREERRRADRREKQVIEKESRWREQAED--------QENQRQ 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1250 QRLSWLRAQVQSSTQADEDQIRaEQEASLQKLRE--ELESQQKAERASLEQKNRQMLEQLKeeIEASEKSEQAALNAAKE 1327
Cdd:pfam15558  109 EKLERARQEAEQRKQCQEQRLK-EKEEELQALREqnSLQLQERLEEACHKRQLKEREEQKK--VQENNLSELLNHQARKV 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1328 KALQQLREQLEGERKeavaTLEKEHSAELERLCSSLEAKHREvvsslqkkIQEAQQKEEAQLQKclgqvehrvhqksyhv 1407
Cdd:pfam15558  186 LVDCQAKAEELLRRL----SLEQSLQRSQENYEQLVEERHRE--------LREKAQKEEEQFQR---------------- 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1408 agyehelsslLREKRQEVEGEHERRLDKMKEEHQQVMAKAReQYEAEERKQRAELLGHLTGELERLQRAHERELEtvRQE 1487
Cdd:pfam15558  238 ----------AKWRAEEKEEERQEHKEALAELADRKIQQAR-QVAHKTVQDKAQRARELNLEREKNHHILKLKVE--KEE 304

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1488 QHKR---LEDLRRRHREQERKLQDLELDLETRAKDVKARLALLE-VQEETARR 1536
Cdd:pfam15558  305 KCHRegiKEAIKKKEQRSEQISREKEATLEEARKTARASFHMREkVREETNNR 357
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1082-1370 2.89e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 2.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1082 GQPEWKEAEELgEDSAASLSlQLSLQREQAPSPPAACEKGKEQhsQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTE 1161
Cdd:TIGR02169  729 EQEEEKLKERL-EELEEDLS-SLEQEIENVKSELKELEARIEE--LEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLE 804

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1162 pvappEQLS--EAALKAMEEAVaQVLEQDQRHLLESKQEKMQQLRE------KLCQEEEEEILRL---------HQQKEQ 1224
Cdd:TIGR02169  805 -----EEVSriEARLREIEQKL-NRLTLEKEYLEKEIQELQEQRIDlkeqikSIEKEIENLNGKKeeleeeleeLEAALR 878

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1225 SLSSLRERLQKAIEEEEARMREEEsQRLSWLRAQVQsstqaDEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQM- 1303
Cdd:TIGR02169  879 DLESRLGDLKKERDELEAQLRELE-RKIEELEAQIE-----KKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELs 952

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572500 1304 LEQLKEEIEASEKsEQAALNAAKEKALQQLREQLE--GERKEAVATLEKEHSAELERLcSSLEAKHREV 1370
Cdd:TIGR02169  953 LEDVQAELQRVEE-EIRALEPVNMLAIQEYEEVLKrlDELKEKRAKLEEERKAILERI-EEYEKKKREV 1019
PRK12704 PRK12704
phosphodiesterase; Provisional
 1361-1568 3.19e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.54  E-value: 3.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1361 SSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHqksyhvagyehelssllrEKRQEVEGEHERRLDKMKEEH 1440
Cdd:PRK12704    27 KIAEAKIKEAEEEAKRILEEAKKEAEAIKKEALLEAKEEIH------------------KLRNEFEKELRERRNELQKLE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1441 QQVMAKareqyeaEER-KQRAELLGHLTGELErlqrAHERELETVRQEQHKRLEDLRRRHREQERKLQDL-ELDLEtrak 1518
Cdd:PRK12704    89 KRLLQK-------EENlDRKLELLEKREEELE----KKEKELEQKQQELEKKEEELEELIEEQLQELERIsGLTAE---- 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1519 dvKARLALLEVQEETARREKQQLLdvqRQValkSEEATathqqlEEAQKE 1568
Cdd:PRK12704   154 --EAKEILLEKVEEEARHEAAVLI---KEI---EEEAK------EEADKK 189
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 1433-1596 3.37e-04

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 43.99  E-value: 3.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1433 LDKMKEEHQQVMAKAREQY-----EAEERKQRAEL-LGHLTGELERLQRAHERELETVRQeQHKRLEDLRRRHREQERKL 1506
Cdd:pfam14988    9 LAKKTEEKQKKIEKLWNQYvqeceEIERRRQELASrYTQQTAELQTQLLQKEKEQASLKK-ELQALRPFAKLKESQEREI 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1507 QDLELDLET--RAKDVKARLALLEVQEETARREKQ-QLLDVQRQVALKSEEATATHQQLEEAQK----EHTHLL-QSNQQ 1578
Cdd:pfam14988   88 QDLEEEKEKvrAETAEKDREAHLQFLKEKALLEKQlQELRILELGERATRELKRKAQALKLAAKqalsEFCRSIkRENRQ 167

                          170       180
                   ....*....|....*....|....*
gi 1034572500 1579 LREIL-------DELQARKLKLESQ 1596
Cdd:pfam14988  168 LQKELlqliqetQALEAIKSKLENR 192
Taxilin pfam09728
Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain ...
 1283-1598 3.57e-04

Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.


Pssm-ID: 462861 [Multi-domain]  Cd Length: 302  Bit Score: 44.94  E-value: 3.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1283 EELESQQKAERASLEQKNrQMLEQLKEEIEASEKSEQAALNAAKEKA--LQQLREQLEGERKEAVATLEKehsaeLERLC 1360
Cdd:pfam09728    3 ARELMQLLNKLDSPEEKL-AALCKKYAELLEEMKRLQKDLKKLKKKQdqLQKEKDQLQSELSKAILAKSK-----LEKLC 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1361 SSLEAKHREVVSSLQKKIQEAQQKEE---AQLQKCLGQVEHRVHQKSYHVAGYEHElSSLLREKRQEVEGEHERR----- 1432
Cdd:pfam09728   77 RELQKQNKKLKEESKKLAKEEEEKRKelsEKFQSTLKDIQDKMEEKSEKNNKLREE-NEELREKLKSLIEQYELRelhfe 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1433 -LDKMKEEHQQ-VMAKAREQYEAEERKQRaellghltgelerlqrahERELETVRQEQhKRLEDLRrrhrEQERKLQD-L 1509
Cdd:pfam09728  156 kLLKTKELEVQlAEAKLQQATEEEEKKAQ------------------EKEVAKARELK-AQVQTLS----ETEKELREqL 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1510 ELDLEtRAKDVKARLALLEVQEETARREKQQLLDVQRQValkSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQAR 1589
Cdd:pfam09728  213 NLYVE-KFEEFQDTLNKSNEVFTTFKKEMEKMSKKIKKL---EKENLTWKRKWEKSNKALLEMAEERQKLKEELEKLQKK 288


                   ....*....
gi 1034572500 1590 KLKLESQVD 1598
Cdd:pfam09728  289 LEKLENLCR 297
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 1279-1381 3.69e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 43.29  E-value: 3.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1279 QKLREELESQQKAERASLEQKNRQmLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAvatlEKEhsaeler 1358
Cdd:COG2825     42 KAAQKKLEKEFKKRQAELQKLEKE-LQALQEKLQKEAATLSEEERQKKERELQKKQQELQRKQQEA----QQD------- 109

                           90       100
                   ....*....|....*....|...
gi 1034572500 1359 lcssLEAKHREVVSSLQKKIQEA 1381
Cdd:COG2825    110 ----LQKRQQELLQPILEKIQKA 128
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1414-1595 3.85e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 3.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1414 LSSLLREKRQEVEgEHERRLDKMKEEHQQVMAKAREQYEAEE----RKQRAELLGHLTgELERLQRAHERELETVRQE-- 1487
Cdd:COG3206    180 LEEQLPELRKELE-EAEAALEEFRQKNGLVDLSEEAKLLLQQlselESQLAEARAELA-EAEARLAALRAQLGSGPDAlp 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1488 ---QHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLL-DVQRQVALKSEEATATHQQLE 1563
Cdd:COG3206    258 ellQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILaSLEAELEALQAREASLQAQLA 337

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1034572500 1564 EAQKEHTHLLQSNQQLREILDELQARKLKLES 1595
Cdd:COG3206    338 QLEARLAELPELEAELRRLEREVEVARELYES 369
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1267-1391 3.85e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.15  E-value: 3.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1267 EDQIRAEQEA--SLQKLREELESQQKAERASLEQKNRQM--------LEQLKEEIEASEKSEQAAlnaakEKALQQLREQ 1336
Cdd:COG1579     44 EARLEAAKTEleDLEKEIKRLELEIEEVEARIKKYEEQLgnvrnnkeYEALQKEIESLKRRISDL-----EDEILELMER 118

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034572500 1337 LEgERKEAVATLEKEHsAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQK 1391
Cdd:COG1579    119 IE-ELEEELAELEAEL-AELEAELEEKKAELDEELAELEAELEELEAEREELAAK 171
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1171-1383 3.95e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 45.71  E-value: 3.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVleqdqrhlleSKQEKMQQLREKLCQeeeeeiLRLHQQKEQSLSSLRERLQKAieeeearmreeeSQ 1250
Cdd:COG3096    475 EKAYELVCKIAGEV----------ERSQAWQTARELLRR------YRSQQALAQRLQQLRAQLAEL------------EQ 526

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 RLswlRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKN----------RQMLEQLKEEIEASEKSEQA 1320
Cdd:COG3096    527 RL---RQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAaeaveqrselRQQLEQLRARIKELAARAPA 603

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1321 ALNAAkeKALQQLREQLEGERKEAVA-------TLEKEHSAELERlcSSLEAKHREvvssLQKKIQEAQQ 1383
Cdd:COG3096    604 WLAAQ--DALERLREQSGEALADSQEvtaamqqLLEREREATVER--DELAARKQA----LESQIERLSQ 665
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1279-1384 5.65e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 42.19  E-value: 5.65e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  1279 QKLREELESQQKAERASLEQKNRQmLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKehsaeler 1358
Cdd:smart00935   17 KAAQKQLEKEFKKRQAELEKLEKE-LQKLKEKLQKDAATLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQK-------- 87

                            90       100
                    ....*....|....*....|....*.
gi 1034572500  1359 lcssleaKHREVVSSLQKKIQEAQQK 1384
Cdd:smart00935   88 -------RQQEELQKILDKINKAIKE 106
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1263-1543 5.92e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 45.02  E-value: 5.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1263 TQADEDQIRAEQEASLQKLREELESQQKAERasleqKNRQMLEQLKEEIEASEKSEQAALNAAKEkaLQQLREQLEGERK 1342
Cdd:pfam05667  217 AAAQEWEEEWNSQGLASRLTPEEYRKRKRTK-----LLKRIAEQLRSAALAGTEATSGASRSAQD--LAELLSSFSGSST 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1343 EAVATLEKEHSAELERLCSSLEAKHREVVSSLQKK----IQEAQQKEEAQLQKCLGQVEHRVHQksyhvagYEHELSSLL 1418
Cdd:pfam05667  290 TDTGLTKGSRFTHTEKLQFTNEAPAATSSPPTKVEteeeLQQQREEELEELQEQLEDLESSIQE-------LEKEIKKLE 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1419 REKRQ-EVEGEHERRLDKMKEEHQQVMAKAREQY-EAEER--------KQRAELLGHLTGELERLQRAHERELETVRQEQ 1488
Cdd:pfam05667  363 SSIKQvEEELEELKEQNEELEKQYKVKKKTLDLLpDAEENiaklqalvDASAQRLVELAGQWEKHRVPLIEEYRALKEAK 442

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572500 1489 HKRLEdlrrrhrEQERKLQDLEldlETRAKdvkarlaLLEVQEETARRE--KQQLLD 1543
Cdd:pfam05667  443 SNKED-------ESQRKLEEIK---ELREK-------IKEVAEEAKQKEelYKQLVA 482
Ax_dynein_light pfam10211
Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in ...
 1268-1339 6.35e-04

Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organizms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.


Pssm-ID: 463000 [Multi-domain]  Cd Length: 187  Bit Score: 42.95  E-value: 6.35e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034572500 1268 DQIRAEQEASLQKLREELESQQKaERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKeKALQQLREQLEG 1339
Cdd:pfam10211  118 EQGKAELEKKIADLEEEKEELEK-QVAELKAKCEAIEKREEERRQAEEKKHAEEIAFLK-KTNQQLKAQLER 187
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1296-1590 7.84e-04

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 44.44  E-value: 7.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1296 LEQKNRQMLEQLKEEIEASEKSeQAALNAAKEKaLQQLREQLEGERK---EAVATLEKEHS------AELERLCSS---L 1363
Cdd:PRK04778   117 IEEDIEQILEELQELLESEEKN-REEVEQLKDL-YRELRKSLLANRFsfgPALDELEKQLEnleeefSQFVELTESgdyV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1364 EAkhREVVSSLQKKIQEAQQKEE------AQLQKCL-GQVEhrvhqksyhvagyehELSSLLREkrQEVEGEH------E 1430
Cdd:PRK04778   195 EA--REILDQLEEELAALEQIMEeipellKELQTELpDQLQ---------------ELKAGYRE--LVEEGYHldhldiE 255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1431 RRLDKMKEEHQQVMAkareQYEAEERKQRAELLGHLTGELERLQRAHERELETvRQEQHKRLEDLRRRHREQERKLQDLE 1510
Cdd:PRK04778   256 KEIQDLKEQIDENLA----LLEELDLDEAEEKNEEIQERIDQLYDILEREVKA-RKYVEKNSDTLPDFLEHAKEQNKELK 330

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1511 LDLETrakdVKARLALLEVQEETARREKQQLLDVQRQVaLKSEEATATHQ---------------QLEEAQKEHTHLLQS 1575
Cdd:PRK04778   331 EEIDR----VKQSYTLNESELESVRQLEKQLESLEKQY-DEITERIAEQEiayselqeeleeilkQLEEIEKEQEKLSEM 405

                          330
                   ....*....|....*
gi 1034572500 1576 NQQLREilDELQARK 1590
Cdd:PRK04778   406 LQGLRK--DELEARE 418
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1470-1634 8.55e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.24  E-value: 8.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1470 LERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLE-----LDLETRAKDVKARLALLEVQEETARRE------- 1537
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRqknglVDLSEEAKLLLQQLSELESQLAEARAElaeaear 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1538 ---------------------------KQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQS-NQQLREILDELQAR 1589
Cdd:COG3206    242 laalraqlgsgpdalpellqspviqqlRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQlQQEAQRILASLEAE 321

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1034572500 1590 KLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENN 1634
Cdd:COG3206    322 LEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVAREL 366
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1470-1653 8.63e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 8.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1470 LERLQRAHER--ELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDV--Q 1545
Cdd:COG1579      9 LLDLQELDSEldRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVrnN 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1546 RQV-ALKSEEATATHQQ--LEEAQKEHTHLLqsnQQLREILDELQARKLKLESQVDLLQaqsqqlqkhfSSLEAEAQKKQ 1622
Cdd:COG1579     89 KEYeALQKEIESLKRRIsdLEDEILELMERI---EELEEELAELEAELAELEAELEEKK----------AELDEELAELE 155

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1034572500 1623 HLLREVTVEENNASPHFEPDL--HIEDLRKSLG 1653
Cdd:COG1579    156 AELEELEAEREELAAKIPPELlaLYERIRKRKN 188
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1224-1563 9.50e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 44.36  E-value: 9.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1224 QSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQ---QKAERASLEQKN 1300
Cdd:pfam07111   59 QALSQQAELISRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELDALAVAEKAGQAEAEGLRAAlagAEMVRKNLEEGS 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1301 RQMLEqlkeEIEASEKSEQAALNAAKEKALQQLREQLEGERKeAVATLEKEHSAELERLcsSLEAKHREVvssLQKKIQE 1380
Cdd:pfam07111  139 QRELE----EIQRLHQEQLSSLTQAHEEALSSLTSKAEGLEK-SLNSLETKRAGEAKQL--AEAQKEAEL---LRKQLSK 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1381 AQQKEEAQ------LQKCLG-QVEHRVHQKSYHVAGYEH-ELSSLLREKRQEVEGEHE---------RRLDKMKEEHQQV 1443
Cdd:pfam07111  209 TQEELEAQvtlvesLRKYVGeQVPPEVHSQTWELERQELlDTMQHLQEDRADLQATVEllqvrvqslTHMLALQEEELTR 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1444 MAKAREQYEAEERKQRAELLGH-------LTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQ---ERKLQDLELDL 1513
Cdd:pfam07111  289 KIQPSDSLEPEFPKKCRSLLNRwrekvfaLMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQEQailQRALQDKAAEV 368

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1514 ETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLE 1563
Cdd:pfam07111  369 EVERMSAKGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLE 418
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1305-1391 9.66e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 41.42  E-value: 9.66e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  1305 EQLKEEIEASEKSEQAALNAaKEKALQQLREQLEGERkeavATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQK 1384
Cdd:smart00935   17 KAAQKQLEKEFKKRQAELEK-LEKELQKLKEKLQKDA----ATLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQE 91


                    ....*..
gi 1034572500  1385 EEAQLQK 1391
Cdd:smart00935   92 ELQKILD 98
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 1373-1568 9.85e-04

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 42.58  E-value: 9.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1373 SLQKKIQEAQQK-EEAQL-QKCLGQVEHRvHQKSYH-VAGYEHELSSLLREKRQEVEgeherrldKMKEEHQQVMAKARE 1449
Cdd:pfam15619   15 ELQNELAELQSKlEELRKeNRLLKRLQKR-QEKALGkYEGTESELPQLIARHNEEVR--------VLRERLRRLQEKERD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1450 QyEAEERKQRAELLgHLTGELERLQR-AHERELETvRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLAlle 1528
Cdd:pfam15619   86 L-ERKLKEKEAELL-RLRDQLKRLEKlSEDKNLAE-REELQKKLEQLEAKLEDKDEKIQDLERKLELENKSFRRQLA--- 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1034572500 1529 vqeetarREKQQLLDVQRQVALKSEEATATHQQLEEAQKE 1568
Cdd:pfam15619  160 -------AEKKKHKEAQEEVKILQEEIERLQQKLKEKERE 192
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1084-1524 1.03e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.44  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1084 PEWKEAEELGEDSAASLSLQLslQREQAPSPPAACEKGKEQHSQAEE-LGPGQEEAEDPEEKVAVsptppVSPEVrstEP 1162
Cdd:pfam12128  567 PEVWDGSVGGELNLYGVKLDL--KRIDVPEWAASEEELRERLDKAEEaLQSAREKQAAAEEQLVQ-----ANGEL---EK 636

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1163 VAPPEQLSEAALKAMEEAVAQ---VLEQDQRHLLES-------KQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRER 1232
Cdd:pfam12128  637 ASREETFARTALKNARLDLRRlfdEKQSEKDKKNKAlaerkdsANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEK 716

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1233 LQKaiEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKL--REELESQQKAERASLEQK------NRQML 1304
Cdd:pfam12128  717 QAY--WQVVEGALDAQLALLKAAIAARRSGAKAELKALETWYKRDLASLgvDPDVIAKLKREIRTLERKieriavRRQEV 794

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1305 ---EQLKEEIEASEKSEQAALNAAKEKALQQLREQL---EGERKEAVATLEKEHSAeLERLCSSLEAKHREVVSSLQK-- 1376
Cdd:pfam12128  795 lryFDWYQETWLQRRPRLATQLSNIERAISELQQQLarlIADTKLRRAKLEMERKA-SEKQQVRLSENLRGLRCEMSKla 873

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1377 KIQEAQQKEEAQLQ--KCLGQVEHRVHQKSYHVAGYEHELS---SLLREKRQEVEGEHERRLdkMKEEHQQVMAKAREQY 1451
Cdd:pfam12128  874 TLKEDANSEQAQGSigERLAQLEDLKLKRDYLSESVKKYVEhfkNVIADHSGSGLAETWESL--REEDHYQNDKGIRLLD 951

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1452 EAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQ---DLELDLEtRAKDVKARL 1524
Cdd:pfam12128  952 YRKLVPYLEQWFDVRVPQSIMVLREQVSILGVDLTEFYDVLADFDRRIASFSRELQrevGEEAFFE-GVSESAVRI 1026
PRK12705 PRK12705
hypothetical protein; Provisional
 1410-1568 1.04e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 43.93  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1410 YEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAEllghLTGELERLQRAHEreletVRQEQH 1489
Cdd:PRK12705    27 KRQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARREREE----LQREEERLVQKEE-----QLDARA 97

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572500 1490 KRLEDLRRRHREQERKLQDLELDLETRAKDVKARlaLLEVQEETARREKQQLLDvQRQVALKSEEATATHQQLEEAQKE 1568
Cdd:PRK12705    98 EKLDNLENQLEEREKALSARELELEELEKQLDNE--LYRVAGLTPEQARKLLLK-LLDAELEEEKAQRVKKIEEEADLE 173
DUF1978 pfam09321
Domain of unknown function (DUF1978); Members of this family are found in various hypothetical ...
 1419-1596 1.14e-03

Domain of unknown function (DUF1978); Members of this family are found in various hypothetical proteins produced by the bacterium Chlamydia pneumoniae. Their exact function has not, as yet, been identified.


Pssm-ID: 312723 [Multi-domain]  Cd Length: 244  Bit Score: 42.99  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1419 REKRQEVEgEHERRLDKMKEEHQQ-VMAKAREQYEAEERKQRAELLGHLTGELER-LQRAHERELETVRQeqhkRLEDLR 1496
Cdd:pfam09321   53 RDALSEIS-RHELWEKKAHLKHLEsLYTQARDRFEKQSSKKNQKELEEAEQEYLSsWEDVKDQEIERVQE----RLQALQ 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1497 RRH-----REQERKLQD---LELDLETRAKDVKARL-ALLEVQEETARREKQQLLDV-----QRQVALKSEEATATHQQL 1562
Cdd:pfam09321  128 ALYpevsvSEEETEGQEtvtPTVDLETALGRIEESYrECVRDQEDYWKEEESKEVEMsaefrEEGGKKKSEEFQEQLGSL 207

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1034572500 1563 EEAQKEHThllqsnqqlrEILDELQARKLKLESQ 1596
Cdd:pfam09321  208 ERFLKEHS----------EELEVLEKHILKHESE 231
Taxilin pfam09728
Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain ...
 1328-1598 1.19e-03

Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.


Pssm-ID: 462861 [Multi-domain]  Cd Length: 302  Bit Score: 43.02  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1328 KALQQLREQLEGerkeaVATLEkEHSAELERLCSSLEAKHREVVSSLQKkiqeaQQKEEAQLQKCLGQVEHrvhqksyhv 1407
Cdd:pfam09728    1 KAARELMQLLNK-----LDSPE-EKLAALCKKYAELLEEMKRLQKDLKK-----LKKKQDQLQKEKDQLQS--------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1408 agyEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMakareqyeAEERKQRAELLGHLTGELERLQrahereletvrqe 1487
Cdd:pfam09728   61 ---ELSKAILAKSKLEKLCRELQKQNKKLKEESKKLA--------KEEEEKRKELSEKFQSTLKDIQ------------- 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1488 qhKRLEDlrrrHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKqqllDVQRQVALKSEEATATHQQLEEAQK 1567
Cdd:pfam09728  117 --DKMEE----KSEKNNKLREENEELREKLKSLIEQYELRELHFEKLLKTK----ELEVQLAEAKLQQATEEEEKKAQEK 186

                          250       260       270
                   ....*....|....*....|....*....|.
gi 1034572500 1568 EHTHLLQSNQQLREILDELQARKLKLESQVD 1598
Cdd:pfam09728  187 EVAKARELKAQVQTLSETEKELREQLNLYVE 217
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1268-1589 1.25e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 43.74  E-value: 1.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1268 DQIRAEQEASLQKLREELESQQ--------------KAERASLEQK------NRQMLEQLKEEIEASEKSEQAALNAAKE 1327
Cdd:pfam15964  359 EQLKSELERQKERLEKELASQQekraqekealrkemKKEREELGATmlalsqNVAQLEAQVEKVTREKNSLVSQLEEAQK 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1328 KALQQ----------LREQLEG---ERKEAvatlEKEHSAELERLCSSLEAKHREV------VSSLQKKIQEAQQK---- 1384
Cdd:pfam15964  439 QLASQemdvtkvcgeMRYQLNQtkmKKDEA----EKEHREYRTKTGRQLEIKDQEIeklgleLSESKQRLEQAQQDaara 514

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1385 --EEAQLQKCLGQVEHRVHqksyhvagyeheLSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAEL 1462
Cdd:pfam15964  515 reECLKLTELLGESEHQLH------------LTRLEKESIQQSFSNEAKAQALQAQQREQELTQKMQQMEAQHDKTVNEQ 582

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1463 LGHLTGelerlQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLL 1542
Cdd:pfam15964  583 YSLLTS-----QNTFIAKLKEECCTLAKKLEEITQKSRSEVEQLSQEKEYLQDRLEKLQKRNEELEEQCVQHGRMHERMK 657

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 1034572500 1543 DVQRQVALKSEeatATHQQLEEAQKEHTHLLQSNQQLREILDELQAR 1589
Cdd:pfam15964  658 QRLRQLDKHCQ---ATAQQLVQLLSKQNQLFKERQNLTEEVQSLRSQ 701
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1171-1359 1.36e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 1.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVLEQdqrhlLESKQEKMQQLREKLcqeeeEEILRLHQQKEQSLSSLRERLQkaieeeearmreeesq 1250
Cdd:COG1579     23 EHRLKELPAELAELEDE-----LAALEARLEAAKTEL-----EDLEKEIKRLELEIEEVEARIK---------------- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 rlswlRAQVQSSTQADEDQIRA--EQEASLQKLREELESQQKAERASLEQKNRQmLEQLKEEIEASEK---SEQAALNAA 1325
Cdd:COG1579     77 -----KYEEQLGNVRNNKEYEAlqKEIESLKRRISDLEDEILELMERIEELEEE-LAELEAELAELEAeleEKKAELDEE 150

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1034572500 1326 KEKaLQQLREQLEGERKEAVATLEKEHSAELERL 1359
Cdd:COG1579    151 LAE-LEAELEELEAEREELAAKIPPELLALYERI 183
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 1471-1591 1.37e-03

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 43.05  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1471 ERLQRAHERELETVRQEQHkrLEDLRRRHREQERKLQDLELDLETRAKDVKA-RLALLEVQEETARREKQQLLDVQRQVA 1549
Cdd:pfam07767  199 ELLQKAVEAEKKRLKEEEK--LERVLEKIAESAATAEAREEKRKTKAQRNKEkRRKEEEREAKEEKALKKKLAQLERLKE 276

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1034572500 1550 LKSEEAtathQQLEEAQKEHTHLLQSNQQLREILDELQARKL 1591
Cdd:pfam07767  277 IAKEIA----EKEKEREEKAEARKREKRKKKKEEKKLRPRKL 314
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1441-1591 1.61e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 43.31  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1441 QQVMAKAREQYEAEERKQR-------AELLGHLTgelERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLE--- 1510
Cdd:COG2433    353 ERVEKKVPPDVDRDEVKARvirglsiEEALEELI---EKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEaev 429

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1511 LDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARK 1590
Cdd:COG2433    430 EELEAELEEKDERIERLERELSEARSEERREIRKDREISRLDREIERLERELEEERERIEELKRKLERLKELWKLEHSGE 509


                   .
gi 1034572500 1591 L 1591
Cdd:COG2433    510 L 510
dnaK PRK00290
molecular chaperone DnaK; Provisional
 1259-1388 1.68e-03

molecular chaperone DnaK; Provisional


Pssm-ID: 234715 [Multi-domain]  Cd Length: 627  Bit Score: 43.55  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1259 VQSSTQADEDQI-RAEQEASL-----QKLREELESQQKAEraSLEQKNRQMLEQLKEEIEASEKSEQaalnaakEKALQQ 1332
Cdd:PRK00290   494 ITASSGLSDEEIeRMVKDAEAnaeedKKRKELVEARNQAD--SLIYQTEKTLKELGDKVPADEKEKI-------EAAIKE 564

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1333 LREQLEGERKEAVatleKEHSAELErlcssleakhrEVVSSLQKKIQEAQQKEEAQ 1388
Cdd:PRK00290   565 LKEALKGEDKEAI----KAKTEELT-----------QASQKLGEAMYQQAQAAQGA 605
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1171-1519 1.70e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1171 EAALKAMEEAVAQVleQDQRHLLESKQEKMQQLREKLCQEEEEEilrlhQQKEQSLSSLRERLQKAieeeearmreeeSQ 1250
Cdd:COG4372     34 RKALFELDKLQEEL--EQLREELEQAREELEQLEEELEQARSEL-----EQLEEELEELNEQLQAA------------QA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1251 RLSWLRAQVQSsTQADEDQIRAEQEAsLQKLREELESQQKAERASLEQKNRQM-------------LEQLKEEIEASEKS 1317
Cdd:COG4372     95 ELAQAQEELES-LQEEAEELQEELEE-LQKERQDLEQQRKQLEAQIAELQSEIaereeelkeleeqLESLQEELAALEQE 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1318 EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE 1397
Cdd:COG4372    173 LQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELL 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1398 HRVHQKSYHVAGYEhelssLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAH 1477
Cdd:COG4372    253 EEVILKEIEELELA-----ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKK 327

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1034572500 1478 ERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 1519
Cdd:COG4372    328 LELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVAD 369
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1279-1384 1.77e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 40.64  E-value: 1.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1279 QKLREELESQQKAERASLEQKNRQmLEQLKEEIEAsEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKehsaeler 1358
Cdd:pfam03938   18 KAAQAQLEKKFKKRQAELEAKQKE-LQKLYEELQK-DGALLEEEREEKEQELQKKEQELQQLQQKAQQELQK-------- 87

                           90       100
                   ....*....|....*....|....*.
gi 1034572500 1359 lcssleaKHREVVSSLQKKIQEAQQK 1384
Cdd:pfam03938   88 -------KQQELLQPIQDKINKAIKE 106
PRK11281 PRK11281
mechanosensitive channel MscK;
1271-1598 1.86e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 43.36  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1271 RAEQEASLQKL--REELESQQKAERASLEQ---------KNRQMLEQLKEEIEASE---KSEQAALNAAKEKALQQLREQ 1336
Cdd:PRK11281    38 EADVQAQLDALnkQKLLEAEDKLVQQDLEQtlalldkidRQKEETEQLKQQLAQAPaklRQAQAELEALKDDNDEETRET 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1337 LEgerKEAVATLEK---EHSAELERLCSSLEAKHREVVSS------LQKKIQEAQQkeeaQLQkclgqvehrvhqksyhv 1407
Cdd:PRK11281   118 LS---TLSLRQLESrlaQTLDQLQNAQNDLAEYNSQLVSLqtqperAQAALYANSQ----RLQ----------------- 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1408 agyehELSSLLreKRQEVEGEHERRLDKMKEEHQQVMAKAREQYeaeerkQRAELLGH--LTgELERLQraheRELETVR 1485
Cdd:PRK11281   174 -----QIRNLL--KGGKVGGKALRPSQRVLLQAEQALLNAQNDL------QRKSLEGNtqLQ-DLLQKQ----RDYLTAR 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1486 QEQhkrledlrrrhreQERKLQDL-ELDLETRAKDVKARLALLEVQEETARREKQQLldVQRQvalkSEEATATHQQLEE 1564
Cdd:PRK11281   236 IQR-------------LEHQLQLLqEAINSKRLTLSEKTVQEAQSQDEAARIQANPL--VAQE----LEINLQLSQRLLK 296

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1034572500 1565 AQKEHTHLLQSNQQLREILDELQARKLKLESQVD 1598
Cdd:PRK11281   297 ATEKLNTLTQQNLRVKNWLDRLTQSERNIKEQIS 330
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1414-1587 1.87e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.19  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1414 LSSLLREKRQEvEGEHERRLDKMKEEhqqvmAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVR--QEQHKR 1491
Cdd:pfam05557   11 LSQLQNEKKQM-ELEHKRARIELEKK-----ASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAElnRLKKKY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1492 LEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTH 1571
Cdd:pfam05557   85 LEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSS 164

                          170
                   ....*....|....*.
gi 1034572500 1572 LLQSNQQLREILDELQ 1587
Cdd:pfam05557  165 LAEAEQRIKELEFEIQ 180
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1324-1499 1.95e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 1.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1324 AAKEKALQQLREQLeGERKEAVATLEKEHsAELERLCSSLEAKHREV---VSSLQKKIQEAQQKEEaQLQKCLGQVehrv 1400
Cdd:COG1579     13 QELDSELDRLEHRL-KELPAELAELEDEL-AALEARLEAAKTELEDLekeIKRLELEIEEVEARIK-KYEEQLGNV---- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1401 hQKSYHVAGYEHELSSLlrEKRQEVEGEHERRLDKMKEEHQQVMAKAREQYE------AEERKQRAELLGHLTGELERLQ 1474
Cdd:COG1579     86 -RNNKEYEALQKEIESL--KRRISDLEDEILELMERIEELEEELAELEAELAeleaelEEKKAELDEELAELEAELEELE 162

                          170       180
                   ....*....|....*....|....*
gi 1034572500 1475 RAHERELETVRQEQHKRLEDLRRRH 1499
Cdd:COG1579    163 AEREELAAKIPPELLALYERIRKRK 187
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1294-1387 1.95e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.15  E-value: 1.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1294 ASLEQKNRQmLEQLKEEIEASEKsEQAALNAAKEKALQQLREQLEGERKEAVA--TLEKEHSAELERLCSSLEAKHrEVV 1371
Cdd:COG0542    411 EELDELERR-LEQLEIEKEALKK-EQDEASFERLAELRDELAELEEELEALKArwEAEKELIEEIQELKEELEQRY-GKI 487

                           90
                   ....*....|....*.
gi 1034572500 1372 SSLQKKIQEAQQKEEA 1387
Cdd:COG0542    488 PELEKELAELEEELAE 503
PLC-beta_C pfam08703
PLC-beta C terminal; This domain corresponds to the alpha helical C terminal domain of ...
 1269-1428 2.06e-03

PLC-beta C terminal; This domain corresponds to the alpha helical C terminal domain of phospholipase C beta.


Pssm-ID: 462571 [Multi-domain]  Cd Length: 176  Bit Score: 41.20  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1269 QIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATL 1348
Cdd:pfam08703    2 QVRELKERLEQELLELREEQYEQEKKRKEQHLTEQIQKLKELAREKQAAELKALKESSESEKKEMKKKLERKRLESIQEA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1349 EK--EHSAELERLCSSLEAKH-REVVSS---LQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV-AGYEHELSSLLREK 1421
Cdd:pfam08703   82 KKrtSDKAAQERLKKEINNSHiQEVVQSikqLEEKQKRRQEKLEEKQAECLQQIKEEEPQLQAELnAEYEEKLKGLPAEV 161


                   ....*..
gi 1034572500 1422 RQEVEGE 1428
Cdd:pfam08703  162 RESVKSC 168
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 1479-1552 2.10e-03

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 43.01  E-value: 2.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1479 RELETVRQEQHK---RLEDLRRRHREQERKLQD----LELDLETRAKDVKARLALL-EVQEETARREKQQLLDVQRQVAL 1550
Cdd:PRK11091    78 EQLEESRQRLSRlvaKLEEMRERDLELNVQLKDniaqLNQEIAEREKAEEARQEAFeQLKNEIKEREETQIELEQQSSLL 157


                   ..
gi 1034572500 1551 KS 1552
Cdd:PRK11091   158 RS 159
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1274-1668 2.14e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.11  E-value: 2.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1274 QEASLQKLREELESQQKAERASLEQKNR------QMLEQLKEEIEASEKSEQAALNAAKEKALQ--------QLREQLEG 1339
Cdd:TIGR00606  502 EVKSLQNEKADLDRKLRKLDQEMEQLNHhtttrtQMEMLTKDKMDKDEQIRKIKSRHSDELTSLlgyfpnkkQLEDWLHS 581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1340 ERKEAVATleKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKC--------LGQVEHRVHQKSYH---VA 1408
Cdd:TIGR00606  582 KSKEINQT--RDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCgsqdeesdLERLKEEIEKSSKQramLA 659

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1409 GYEHELSSLLREKRQEVEG--EHERRLDKMKEEHQQVMAKAR--------EQYEAEE-----RKQRAELLGHLTGELERL 1473
Cdd:TIGR00606  660 GATAVYSQFITQLTDENQSccPVCQRVFQTEAELQEFISDLQsklrlapdKLKSTESelkkkEKRRDEMLGLAPGRQSII 739

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1474 QRAhERELETVRQEQHKRLEDLRRRH---REQERKLQDLELDLETrAKDVKARLALLE-VQEETARREKQqlldVQRQVA 1549
Cdd:TIGR00606  740 DLK-EKEIPELRNKLQKVNRDIQRLKndiEEQETLLGTIMPEEES-AKVCLTDVTIMErFQMELKDVERK----IAQQAA 813

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1550 -LKSEEATATHQQL----EEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHL 1624
Cdd:TIGR00606  814 kLQGSDLDRTVQQVnqekQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVEL 893

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1034572500 1625 LREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSK 1668
Cdd:TIGR00606  894 STEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNK 937
CCDC154 pfam15450
Coiled-coil domain-containing protein 154; CCDC154 is an osteopetrosis-related protein that ...
 1260-1487 2.29e-03

Coiled-coil domain-containing protein 154; CCDC154 is an osteopetrosis-related protein that suppresses cell proliferation by inducing G2/M arrest.


Pssm-ID: 464723 [Multi-domain]  Cd Length: 526  Bit Score: 42.90  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1260 QSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKE------EIEASEKSEQAALN---AAKEKAl 1330
Cdd:pfam15450  213 ESTRLKAESSLREELEGRWQKLQELTEERLRALQGQREQEEGHLLEQCRGldaavvQLTKFVRQNQVSLNrvlLAEQKA- 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1331 QQLREQLEGERKEAVATLEKEhsaELERLCSSLEAKHREVVSSLQKKIQEAQQKEE--AQLQKCLGQVEHRVHQKSYHVA 1408
Cdd:pfam15450  292 RDAKGQLEESQAGELASYVQE---NLEAVQLAGELAQQETQGALELLQEKSQVLEGsvAELVRQVKDLSDHFLALSWRLD 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1409 GYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRA------ELLGHLTGELERLQ---RAHER 1479
Cdd:pfam15450  369 LQEQTLGLKLSEAKKEWEGAERKSLEDLAQWQKEVAAHLREVQEKVDSLPRQieavsdKCVLHKSDSDLKISaegKAREF 448


                   ....*...
gi 1034572500 1480 ELETVRQE 1487
Cdd:pfam15450  449 EVEAMRQE 456
ATP-synt_Fo_b cd06503
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...
 1268-1336 2.72e-03

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.


Pssm-ID: 349951 [Multi-domain]  Cd Length: 132  Bit Score: 39.73  E-value: 2.72e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1268 DQIRAEQEASLQKLREELESQ-QKAERASLEQKNrQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ 1336
Cdd:cd06503     50 EELLAEYEEKLAEARAEAQEIiEEARKEAEKIKE-EILAEAKEEAERILEQAKAEIEQEKEKALAELRKE 118
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 1415-1535 2.96e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 42.63  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1415 SSLLREKRQEVEgeherRLDKMKEEHQQvmAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQE-QHKRLE 1493
Cdd:PRK11448   141 ENLLHALQQEVL-----TLKQQLELQAR--EKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKaAETSQE 213

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1034572500 1494 DLRRRHREQERKLQDLELD-LETRAK-DVKARLALLEVQEETAR 1535
Cdd:PRK11448   214 RKQKRKEITDQAAKRLELSeEETRILiDQQLRKAGWEADSKTLR 257
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1453-1635 3.14e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.20  E-value: 3.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1453 AEERKQRAELLGHLTGELERLQRaherELETVRQEQHKRLEDLRRRHREQER---KLQDLELDLETRAKDVKARLALLEV 1529
Cdd:COG4372     30 SEQLRKALFELDKLQEELEQLRE----ELEQAREELEQLEEELEQARSELEQleeELEELNEQLQAAQAELAQAQEELES 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1530 QEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVdlLQAQSQQLQK 1609
Cdd:COG4372    106 LQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL--QALSEAEAEQ 183

                          170       180
                   ....*....|....*....|....*.
gi 1034572500 1610 HFSSLEAEAQKKQHLLREVTVEENNA 1635
Cdd:COG4372    184 ALDELLKEANRNAEKEEELAEAEKLI 209
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
 1470-1589 3.41e-03

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 461130 [Multi-domain]  Cd Length: 215  Bit Score: 41.20  E-value: 3.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1470 LERLQRAHERELETVRQEqhkrLEDLRRRHREQERKLQDLELDLETRAKdvKARLALLEVQEETARREKQQLLDVQRQVA 1549
Cdd:pfam04012   27 LEQAIRDMQSELVKARQA----LAQTIARQKQLERRLEQQTEQAKKLEE--KAQAALTKGNEELAREALAEKKSLEKQAE 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1034572500 1550 LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQAR 1589
Cdd:pfam04012  101 ALETQLAQQRSAVEQLRKQLAALETKIQQLKAKKNLLKAR 140
PRK02292 PRK02292
V-type ATP synthase subunit E; Provisional
 1259-1396 3.63e-03

V-type ATP synthase subunit E; Provisional


Pssm-ID: 235026 [Multi-domain]  Cd Length: 188  Bit Score: 40.75  E-value: 3.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1259 VQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSE--QAALNAAKEkALQQLREQ 1336
Cdd:PRK02292    10 IRDEARARASEIRAEADEEAEEIIAEAEADAEEILEDREAEAEREIEQLREQELSSAKLEakRERLNARKE-VLEDVRNQ 88

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572500 1337 LEgerkEAVATLEKEHSAELER-LCSSLEAKHREVVSS------LQKKIQEAQQKEEAQLQKCLGQV 1396
Cdd:PRK02292    89 VE----DEIASLDGDKREELTKsLLDAADADGVRVYSRkddedlVKSLLSDYDGLEYAGNIDCLGGV 151
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 1411-1542 3.76e-03

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 40.03  E-value: 3.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1411 EHELSSLLREKRQEVEGEHERRLDKMKEE-HQQVMAKAREQYEAEERKQRAEllghltgelERLQRAHERELETVRQEQH 1489
Cdd:pfam15346   21 AKRVEEELEKRKDEIEAEVERRVEEARKImEKQVLEELEREREAELEEERRK---------EEEERKKREELERILEENN 91

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1490 KRLEDLRRRHREQERKlqdlELDLETRAKDVKARLAllEVQEETARREKQQLL 1542
Cdd:pfam15346   92 RKIEEAQRKEAEERLA----MLEEQRRMKEERQRRE--KEEEEREKREQQKIL 138
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 1252-1588 3.91e-03

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 42.28  E-value: 3.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1252 LSWLRA---QVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEaseksEQAALNAA--- 1325
Cdd:pfam08457  141 LTWLRKfrtLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEQEADSFRRRKLLRRALDEWR-----IQARLEPAlrq 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1326 ---------KEKALQQLREQLEGERKEA-VATLEKEHSA----ELERLCSSLEAK--HREVVSSLQK-----------KI 1378
Cdd:pfam08457  216 vsakvdrriLRSALSVWKLRARMSRQAReVDRARILRNAwttwNDELRCKALRERidERLKLEALYKwvleerlrlfqRI 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1379 QEAQQKEEA------QLQKCLGQV-----EHRVHQKSYHVAGYEHELSSLLREKRQE---VEGEHERR-----LDKMKEE 1439
Cdd:pfam08457  296 REQRLKREVlstwvtNTRDTRTRLlrheeEFEEHRNRKLLRSKLLKWRDQLAEQREReiaANEFYAPRllqeaLDAWRER 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1440 HQQVmakarEQYEAEERKQRAELLghLTGELER-----LQRAHERELETVRQEQHKRLEDLRRRH----REQERKLQDLE 1510
Cdd:pfam08457  376 HQHV-----QKLEKWARDARFYFL--ATRTLKKwraatEESRRERRQDAYAQVRRKVKINLARRAlskwRSKAAEVADLE 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1511 ldletrakdvkarlallevQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQ--QLREILDELQA 1588
Cdd:pfam08457  449 -------------------QQADQLRQNRLLEDAIELFDRWRERTAKRKQRAEDADQFYAEQLLRSYlaRWRERLRELRE 509
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1280-1782 4.32e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.31  E-value: 4.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1280 KLREELESQQKAERASLEQKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGER----------KEAVATL 1348
Cdd:TIGR04523  113 KNDKEQKNKLEVELNKLEKQKKENKKNIDKfLTEIKKKEKELEKLNNKYNDLKKQKEELENELnllekeklniQKNIDKI 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1349 EKEHSAeLERLCSSLEAKHREVvSSLQKKIQEAQQKEEaQLQKCLGQVEHRVHQKsyhvagyEHELSSLlREKRQEVEGE 1428
Cdd:TIGR04523  193 KNKLLK-LELLLSNLKKKIQKN-KSLESQISELKKQNN-QLKDNIEKKQQEINEK-------TTEISNT-QTQLNQLKDE 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1429 HERRLDKMKEEHQQVmakareqyeaeerKQRAELLGHLTGELERLqrahERELETVRQE-QHKRLEDLRRRHREQERKLQ 1507
Cdd:TIGR04523  262 QNKIKKQLSEKQKEL-------------EQNNKKIKELEKQLNQL----KSEISDLNNQkEQDWNKELKSELKNQEKKLE 324

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1508 DLELDLETrakdvkarlallevQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQ 1587
Cdd:TIGR04523  325 EIQNQISQ--------------NNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLE 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1588 ARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK--KQHLLREVTVEENNASphfepdlhIEDLRKslgTNQTKEVS-SSL 1664
Cdd:TIGR04523  391 SQINDLESKIQNQEKLNQQKDEQIKKLQQEKELleKEIERLKETIIKNNSE--------IKDLTN---QDSVKELIiKNL 459

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1665 SQSKEDL--YLDSLSshnvwhllsaegvalrsakeflvqqtRSMRRRQTALKAAQqhwrhelasaQEVAKDPPGIKALED 1742
Cdd:TIGR04523  460 DNTRESLetQLKVLS--------------------------RSINKIKQNLEQKQ----------KELKSKEKELKKLNE 503

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 1034572500 1743 MRKNLEKETRHL----DEMKSAMRKGHNLLKKKEEKLNQLESSL 1782
Cdd:TIGR04523  504 EKKELEEKVKDLtkkiSSLKEKIEKLESEKKEKESKISDLEDEL 547
4HB_MCP_1 pfam12729
Four helix bundle sensory module for signal transduction; This family is a four helix bundle ...
 1266-1350 4.38e-03

Four helix bundle sensory module for signal transduction; This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterized in E coli chemoreceptors. This domain recognizes citrate and TCA cycle intermediates, cis-aconitate, boric acid, Phenanthrene, pyrene and benzopyrene (Matilla et el., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 432749 [Multi-domain]  Cd Length: 181  Bit Score: 40.31  E-value: 4.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1266 DEDQiRAEQEASLQKLREELESQQKA-ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAK----EKALQQLREQLEGE 1340
Cdd:pfam12729   73 DPAE-RDELLKDIEELRAEIDKLLEKyEKTILTDEEKKLFAEFKENLNAYRAVRNKVLELAKagnkDEAYQLYKTEGRPA 151

                           90
                   ....*....|
gi 1034572500 1341 RKEAVATLEK 1350
Cdd:pfam12729  152 REAMIEALEE 161
growth_prot_Scy NF041483
polarized growth protein Scy;
1249-1573 4.49e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 42.12  E-value: 4.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1249 SQRLSWLRAQVQSSTQAdedQIRAEQEASLQKLREEL-ESQQKAE-------------RASLEQKNRQMLEQLKEEIEAS 1314
Cdd:NF041483   103 TQRILQEHAEHQARLQA---ELHTEAVQRRQQLDQELaERRQTVEshvnenvawaeqlRARTESQARRLLDESRAEAEQA 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1315 EKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK-----------------EHSAELERLCSSL-----EAKHR--EV 1370
Cdd:NF041483   180 LAAARAEAERLAEEARQRLGSEAESARAEAEAILRRarkdaerllnaastqaqEATDHAEQLRSSTaaesdQARRQaaEL 259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1371 VSSLQKKIQEAQQK---EEAQLQKCLGQVEHRVHQKsyhVAGYEHELSSLLREKRQEVE---GEHERRLDKMKEEHQQVM 1444
Cdd:NF041483   260 SRAAEQRMQEAEEAlreARAEAEKVVAEAKEAAAKQ---LASAESANEQRTRTAKEEIArlvGEATKEAEALKAEAEQAL 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1445 AKAREQYE-----AEERKQRA-----------------ELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQ 1502
Cdd:NF041483   337 ADARAEAEklvaeAAEKARTVaaedtaaqlakaartaeEVLTKASEDAKATTRAAAEEAERIRREAEAEADRLRGEAADQ 416

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034572500 1503 ERKLQDLELD--LETRAKDVkarlallEVQEEtARR---EKQQLLD--VQRQVALKSEEATATHQQLEEAQKEHTHLL 1573
Cdd:NF041483   417 AEQLKGAAKDdtKEYRAKTV-------ELQEE-ARRlrgEAEQLRAeaVAEGERIRGEARREAVQQIEEAARTAEELL 486
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 1264-1390 4.72e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 41.25  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1264 QADEDQIRAEQeASLQKLREELesQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEkALQQLREQLEGERKE 1343
Cdd:pfam00529   57 QAALDSAEAQL-AKAQAQVARL--QAELDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQA-QLAQAQIDLARRRVL 132

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1034572500 1344 AVATL-EKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQ 1390
Cdd:pfam00529  133 APIGGiSRESLVTAGALVAQAQANLLATVAQLDQIYVQITQSAAENQA 180
PKK pfam12474
Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino ...
 1440-1573 4.89e-03

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.


Pssm-ID: 463600 [Multi-domain]  Cd Length: 139  Bit Score: 39.47  E-value: 4.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1440 HQQVMAKAREQYEAEerkqRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHR-EQERKLQDLELDLETRAK 1518
Cdd:pfam12474    1 HQLQKEQQKDRFEQE----RQQLKKRYEKELEQLERQQKQQIEKLEQRQTQELRRLPKRIRaEQKKRLKMFRESLKQEKK 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572500 1519 DVKA---RLALLEVQEET-ARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLL 1573
Cdd:pfam12474   77 ELKQeveKLPKFQRKEAKrQRKEELELEQKHEELEFLQAQSEALERELQQLQNEKRKEL 135
PRK13895 PRK13895
conjugal transfer protein TraM; Provisional
 1298-1368 4.94e-03

conjugal transfer protein TraM; Provisional


Pssm-ID: 184378  Cd Length: 144  Bit Score: 39.66  E-value: 4.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1298 QKNRQ-MLEQLKEEIE---------ASEKSEQ---AALNAAKEKALQQLREQLegerKEAVATLEKEHSAELERLCSSLE 1364
Cdd:PRK13895    41 AKAQQeMLDQFKEELEsiasrwgddAKEKAERilnAALAASKEAMAKGMQEGA----KAAAEAVRREISASLAELAAPVR 116


                   ....
gi 1034572500 1365 AKHR 1368
Cdd:PRK13895   117 EARR 120
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1253-1352 4.99e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 39.49  E-value: 4.99e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  1253 SWLRAQVQSSTQADEDQIRAE---QEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKA 1329
Cdd:smart00935   13 SPAGKAAQKQLEKEFKKRQAElekLEKELQKLKEKLQKDAATLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEE 92

                            90       100
                    ....*....|....*....|...
gi 1034572500  1330 LQQLREQLegerKEAVATLEKEH 1352
Cdd:smart00935   93 LQKILDKI----NKAIKEVAKKK 111
MPS2 pfam17060
Monopolar spindle protein 2; Is a fungal transmembrane protein which is part of the component ...
 1255-1401 5.03e-03

Monopolar spindle protein 2; Is a fungal transmembrane protein which is part of the component of the spindle pole body (SPB) required for the insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. It seems that Mps2-Spc24 interaction may contribute to the localization of Spc24 and other kinetochore components to the inner plaque of the SPB.


Pssm-ID: 407228 [Multi-domain]  Cd Length: 340  Bit Score: 41.50  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1255 LRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQM-LEQLKEEIEASEKseqaaLNAAKEKALQQL 1333
Cdd:pfam17060  106 LKEDVKSSPRSEADSLGTPIKVDLLRNLKPQESPETPRRINRKYKSLELrVESMKDELEFKDE-----TIMEKDRELTEL 180

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034572500 1334 REQLeGERKEAVATLEKEHS-----AELERLCSSLEA-KHREVVSSLQKKIQEaQQKEEAQLQKCLGQVEHRVH 1401
Cdd:pfam17060  181 TSTI-SKLKDKYDFLSREFEfykqhHEHGGNNSIKTAtKHEFIISELKRKLQE-QNRLIRILQEQIQFDPGALH 252
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
1041-1285 5.10e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.68  E-value: 5.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1041 GPDSAALPGLTRL-SPPLPHEERAQSP-PRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAAC 1118
Cdd:PRK14971   374 GPKQHIKPVFTQPaAAPQPSAAAAASPsPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFK 453

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1119 EKGKEQHSQAEELGPG-----QEEAEDPEEKVAVSPTPPvspevrstepvaPPEQLSEAALKAMEEAVAQVLEQDQRHLl 1193
Cdd:PRK14971   454 EEKKIPVSKVSSLGPStlrpiQEKAEQATGNIKEAPTGT------------QKEIFTEEDLQYYWQEFAGTRPQEEKAL- 520

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1194 eskQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAE 1273
Cdd:PRK14971   521 ---KETMINCRPKLLNGTTFEVAVDNELQEKELTNLIPDLLGFLRGRLKNSKITMTVRVSEPTEVNRAYSSVEKFQYLAQ 597

                          250
                   ....*....|..
gi 1034572500 1274 QEASLQKLREEL 1285
Cdd:PRK14971   598 KNPALLELREEL 609
PRK12705 PRK12705
hypothetical protein; Provisional
 1431-1574 5.22e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 41.62  E-value: 5.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1431 RRLDKMKEEHQQVMAKAREqyeaEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQER---KLQ 1507
Cdd:PRK12705    26 KKRQRLAKEAERILQEAQK----EAEEKLEAALLEAKELLLRERNQQRQEARREREELQREEERLVQKEEQLDAraeKLD 101

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1508 DLELDLETRAKDVKARLALLEVQEETARREKQQLL----DVQRQVALKSEEATATHQ--QLEEAQKEHTHLLQ 1574
Cdd:PRK12705   102 NLENQLEEREKALSARELELEELEKQLDNELYRVAgltpEQARKLLLKLLDAELEEEkaQRVKKIEEEADLEA 174
CCDC154 pfam15450
Coiled-coil domain-containing protein 154; CCDC154 is an osteopetrosis-related protein that ...
 1274-1557 5.29e-03

Coiled-coil domain-containing protein 154; CCDC154 is an osteopetrosis-related protein that suppresses cell proliferation by inducing G2/M arrest.


Pssm-ID: 464723 [Multi-domain]  Cd Length: 526  Bit Score: 41.74  E-value: 5.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1274 QEASLQKLREELE-----SQQKAERASLEQKNRQMLEQL-KEEIEASEKSEQAALNAAkEKALQQLREQL-EGERKEAVA 1346
Cdd:pfam15450   40 EHATLSLLRELLQvrahvQLQDSELKQLRQEVQQAARAPeKEALEFPGPQNQNQMQAL-DKRLVEVREALtQIRRKQALQ 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1347 TLEKEHSAE-----LERLCSSL--EAKHREVV-SSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLL 1418
Cdd:pfam15450  119 DSERKGAEQeanlrLTKLTGKLkqEEQGREAAcSALQKSQEEASQKVDHEVARMQAQVTKLGEEMSLRFLKREAKLCSFL 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1419 R------EKRQEVEG----EHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQ 1488
Cdd:pfam15450  199 QksflalEKRMKASEstrlKAESSLREELEGRWQKLQELTEERLRALQGQREQEEGHLLEQCRGLDAAVVQLTKFVRQNQ 278

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572500 1489 HKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATA 1557
Cdd:pfam15450  279 VSLNRVLLAEQKARDAKGQLEESQAGELASYVQENLEAVQLAGELAQQETQGALELLQEKSQVLEGSVA 347
Apolipoprotein pfam01442
Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a ...
 1330-1524 5.53e-03

Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E.


Pssm-ID: 460211 [Multi-domain]  Cd Length: 175  Bit Score: 39.94  E-value: 5.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1330 LQQLREQLEGERKEAVATLEKEhsaeLERLCSSLEAKHREVVSSLQKKIQEAQQKeeaqlqkcLGQvehrvhqksyHVAG 1409
Cdd:pfam01442   13 AEELQEQLGPVAQELVDRLEKE----TEALRERLQKDLEEVRAKLEPYLEELQAK--------LGQ----------NVEE 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1410 YEHELSSLLREKRQEVEgeheRRLDKMKEEHQQVMAKAREQYEAEERKQRAellgHLTGELERLQRAHERELETVRQEQH 1489
Cdd:pfam01442   71 LRQRLEPYTEELRKRLN----ADAEELQEKLAPYGEELRERLEQNVDALRA----RLAPYAEELRQKLAERLEELKESLA 142

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1034572500 1490 KRLEDLRRRHREQerkLQDLELDLETRAKDVKARL 1524
Cdd:pfam01442  143 PYAEEVQAQLSQR---LQELREKLEPQAEDLREKL 174
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1161-1443 5.59e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.96  E-value: 5.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1161 EPVAPPEQLSEAALKAMeeavaQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLR------ERLQ 1234
Cdd:TIGR00606  775 GTIMPEEESAKVCLTDV-----TIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDtvvskiELNR 849

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1235 KAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREEL--ESQQKAERASLEQKNRQMLEQLKEEI- 1311
Cdd:TIGR00606  850 KLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLirEIKDAKEQDSPLETFLEKDQQEKEELi 929

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1312 ---EASEKSEQAALNAAKEKALQQL--REQLEGERKEAVATLEKEHSAELERLCSSLEAKHREvvsslQKKIQEAQQKEE 1386
Cdd:TIGR00606  930 sskETSNKKAQDKVNDIKEKVKNIHgyMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKH-----QEKINEDMRLMR 1004

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572500 1387 AQLQKclGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQV 1443
Cdd:TIGR00606 1005 QDIDT--QKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQMKQEHQKL 1059
PRK11637 PRK11637
AmiB activator; Provisional
 1441-1627 5.93e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 41.22  E-value: 5.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1441 QQVMAkAREQYEAEERKQRAELLGHLTGELE------RLQRAHERELETVRQEQHK---RLEDLRRRHREQERKLQDlEL 1511
Cdd:PRK11637    53 QQDIA-AKEKSVRQQQQQRASLLAQLKKQEEaisqasRKLRETQNTLNQLNKQIDElnaSIAKLEQQQAAQERLLAA-QL 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1512 DLETRAKDVKArLALLEVQEETARREKQQ----LLDVQRQVALksEEATATHQQLEEAQKEhthLLQSNQQLREILDELQ 1587
Cdd:PRK11637   131 DAAFRQGEHTG-LQLILSGEESQRGERILayfgYLNQARQETI--AELKQTREELAAQKAE---LEEKQSQQKTLLYEQQ 204

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1034572500 1588 ARKLKLESqvdllqaQSQQLQKHFSSLEAEAQKKQHLLRE 1627
Cdd:PRK11637   205 AQQQKLEQ-------ARNERKKTLTGLESSLQKDQQQLSE 237
PRK07352 PRK07352
F0F1 ATP synthase subunit B; Validated
 1255-1338 6.35e-03

F0F1 ATP synthase subunit B; Validated


Pssm-ID: 180941 [Multi-domain]  Cd Length: 174  Bit Score: 39.55  E-value: 6.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1255 LRAQVQSSTQADEDQIRAEQEAslQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQA---------ALNAA 1325
Cdd:PRK07352    66 LRQAAQALAEAQQKLAQAQQEA--ERIRADAKARAEAIRAEIEKQAIEDMARLKQTAAADLSAEQErviaqlrreAAELA 143

                           90
                   ....*....|...
gi 1034572500 1326 KEKALQQLREQLE 1338
Cdd:PRK07352   144 IAKAESQLPGRLD 156
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1266-1350 6.40e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 40.82  E-value: 6.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1266 DEDQIRAEQEasLQKLREELESQQKAERASLEQKnrqmLEQLKEEIEASEKSEQAA------LNAAKeKALQQLREQLEg 1339
Cdd:cd22656    171 DEGGAIARKE--IKDLQKELEKLNEEYAAKLKAK----IDELKALIADDEAKLAAAlrliadLTAAD-TDLDNLLALIG- 242

                           90
                   ....*....|.
gi 1034572500 1340 erkEAVATLEK 1350
Cdd:cd22656    243 ---PAIPALEK 250
PTZ00121 PTZ00121
MAEBL; Provisional
 903-1335 6.67e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 6.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  903 KASEKEAPEDTVDAGEEGSRREEAAK--EPKKKASALEEGSSDASQELEISEHMKEPQLSDSIasdpksfhgldfgfrSR 980
Cdd:PTZ00121  1413 AAAAKKKADEAKKKAEEKKKADEAKKkaEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA---------------KK 1477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500  981 ISEHLLDVDVLSPVLGGACRQAQQplgIEDKDDSQSSQDELQSKQSKGLEESSLPALQMEGPDSAALPGLTRLSPPLPHE 1060
Cdd:PTZ00121  1478 KAEEAKKADEAKKKAEEAKKKADE---AKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKA 1554

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1061 ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAED 1140
Cdd:PTZ00121  1555 EELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1141 PEEkvavsPTPPVSPEVRSTEPVAPPEQL-----SEAALKAMEEAV----AQVLEQDQRHLLESKQEKMQQLR--EKLCQ 1209
Cdd:PTZ00121  1635 VEQ-----LKKKEAEEKKKAEELKKAEEEnkikaAEEAKKAEEDKKkaeeAKKAEEDEKKAAEALKKEAEEAKkaEELKK 1709

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1210 EEEEEILRLHQ-QKEQSLSSL------RERLQKAIEEEEARMREEESQRLswlrAQVQSSTQADEDQIRAEQEASLQklr 1282
Cdd:PTZ00121  1710 KEAEEKKKAEElKKAEEENKIkaeeakKEAEEDKKKAEEAKKDEEEKKKI----AHLKKEEEKKAEEIRKEKEAVIE--- 1782

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034572500 1283 EELESQQKAERASLEQKNRQMLEQLKEEIEASEKSeQAALNAAKEKALQQLRE 1335
Cdd:PTZ00121  1783 EELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEG-NLVINDSKEMEDSAIKE 1834
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1269-1787 7.00e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 7.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1269 QIRAEQEASLQKLREELESQQKAER--ASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEkaLQQLREQLEgERKEAVA 1346
Cdd:pfam01576  493 QLEDERNSLQEQLEEEEEAKRNVERqlSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRE--LEALTQQLE-EKAAAYD 569

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1347 TLEKEHS---AELERLCSSLEaKHREVVSSLQKKiqeaqQKeeaQLQKCLGQvehrvhqksyhvagyEHELSSLLREKRQ 1423
Cdd:pfam01576  570 KLEKTKNrlqQELDDLLVDLD-HQRQLVSNLEKK-----QK---KFDQMLAE---------------EKAISARYAEERD 625

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1424 EVEG---EHERRLDKMKEEHQQvMAKAREQYEAEERKQRAEL---------LGHLTGELERLQRAHERELETVRqEQHKR 1491
Cdd:pfam01576  626 RAEAearEKETRALSLARALEE-ALEAKEELERTNKQLRAEMedlvsskddVGKNVHELERSKRALEQQVEEMK-TQLEE 703

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1492 LED---------LRRRHREQ------ERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEAT 1556
Cdd:pfam01576  704 LEDelqatedakLRLEVNMQalkaqfERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELE 783

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1557 AthqQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEA------------------ 1618
Cdd:pfam01576  784 A---QIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELlqlqedlaaserarrqaq 860

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1619 QKKQHLLREVTVEENNASPHFEPDLHIE----DLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHnvwhlLSAEGVALR- 1693
Cdd:pfam01576  861 QERDELADEIASGASGKSALQDEKRRLEariaQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTE-----LAAERSTSQk 935

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1694 --SAKEFLVQQTRSMRRRQTALKAA-----------------------QQHWRHELASAQEVAKDPpgiKALEDMRKNLE 1748
Cdd:pfam01576  936 seSARQQLERQNKELKAKLQEMEGTvkskfkssiaaleakiaqleeqlEQESRERQAANKLVRRTE---KKLKEVLLQVE 1012

                          570       580       590
                   ....*....|....*....|....*....|....*....
gi 1034572500 1749 KETRHLDEMKSAMRKGHNLLKKKEEKLNQLEsslwEEAS 1787
Cdd:pfam01576 1013 DERRHADQYKDQAEKGNSRMKQLKRQLEEAE----EEAS 1047
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1187-1597 7.14e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.57  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1187 QDQRHLLESKQEKMQQLREKLC--QEEEEEILRLHQQKEQSLSSLRERLQ----------------KAIEEEEARMREEE 1248
Cdd:TIGR00606  206 QMELKYLKQYKEKACEIRDQITskEAQLESSREIVKSYENELDPLKNRLKeiehnlskimkldneiKALKSRKKQMEKDN 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1249 SQrLSWLRAQVQSSTQADEDQI-RAEQEASLQKLREELESQQKAERASleqKNRQMLEQLKEEIEASEKSEQAALNAAKE 1327
Cdd:TIGR00606  286 SE-LELKMEKVFQGTDEQLNDLyHNHQRTVREKERELVDCQRELEKLN---KERRLLNQEKTELLVEQGRLQLQADRHQE 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1328 KALQ--------QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKH-REVVSSLQKKIQEAqQKEEAQLQKCLGQVEH 1398
Cdd:TIGR00606  362 HIRArdsliqslATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTaAQLCADLQSKERLK-QEQADEIRDEKKGLGR 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1399 RVHQKSYHVAGYEHELSSLLREKrQEVEGEHERRLDKMKE--EHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRA 1476
Cdd:TIGR00606  441 TIELKKEILEKKQEELKFVIKEL-QQLEGSSDRILELDQElrKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRK 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1477 HERELETVRQEQHKrledlrrrhREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQvalKSEEAT 1556
Cdd:TIGR00606  520 LDQEMEQLNHHTTT---------RTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHS---KSKEIN 587

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1034572500 1557 ATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQV 1597
Cdd:TIGR00606  588 QTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKL 628
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
1478-1596 7.26e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 40.19  E-value: 7.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1478 ERELETVRQE------QHKRLEDLRRRHREQERKLQDleldletrakdvKARLALLEVQEETARR--EKQQLLDvqrqva 1549
Cdd:COG1842     36 EEDLVEARQAlaqviaNQKRLERQLEELEAEAEKWEE------------KARLALEKGREDLAREalERKAELE------ 97

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1034572500 1550 lksEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1596
Cdd:COG1842     98 ---AQAEALEAQLAQLEEQVEKLKEALRQLESKLEELKAKKDTLKAR 141
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1283-1463 7.33e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.35  E-value: 7.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1283 EELESQQKaeraSLEQKNRQmLEQLKEEIEAsekseqaalnaaKEKALQQLREQLEGERKEAVATLEKEhsaelerlcss 1362
Cdd:PRK00409   523 ASLEELER----ELEQKAEE-AEALLKEAEK------------LKEELEEKKEKLQEEEDKLLEEAEKE----------- 574

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1363 leakhrevvssLQKKIQEAqQKEEAQLQKCLgqvehRVHQKSYHVAGYEHELSsllrEKRQEVEGEHErrldkMKEEHQQ 1442
Cdd:PRK00409   575 -----------AQQAIKEA-KKEADEIIKEL-----RQLQKGGYASVKAHELI----EARKRLNKANE-----KKEKKKK 628

                          170       180
                   ....*....|....*....|....*..
gi 1034572500 1443 VMAKAREQYEAEER------KQRAELL 1463
Cdd:PRK00409   629 KQKEKQEELKVGDEvkylslGQKGEVL 655
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1183-1627 7.39e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 41.48  E-value: 7.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1183 QVLEQ--DQRHLLESKQEKMQQLREkLCQeeeeeilRLHQQkeQSLSSLRERLQKAIEEEEARMREEESQrLSWLRAQVQ 1260
Cdd:COG3096    499 ELLRRyrSQQALAQRLQQLRAQLAE-LEQ-------RLRQQ--QNAERLLEEFCQRIGQQLDAAEELEEL-LAELEAQLE 567

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1261 SSTQADEDQIraEQEASLQKLREELESQQK--AERASLEQKNRQMLEQLKEEIEASEKSEQAALNA-----AKEKALQQL 1333
Cdd:COG3096    568 ELEEQAAEAV--EQRSELRQQLEQLRARIKelAARAPAWLAAQDALERLREQSGEALADSQEVTAAmqqllEREREATVE 645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1334 REQLEgERKEAvatLEKE----------HSAELERLCSSL-------------------------EAKHREVVSSLqkki 1378
Cdd:COG3096    646 RDELA-ARKQA---LESQierlsqpggaEDPRLLALAERLggvllseiyddvtledapyfsalygPARHAIVVPDL---- 717

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1379 qEAQQKEEAQLQKCLGQV--------------------EHRVHQKS---------------YHVAGYEHELSSLLREKRQ 1423
Cdd:COG3096    718 -SAVKEQLAGLEDCPEDLyliegdpdsfddsvfdaeelEDAVVVKLsdrqwrysrfpevplFGRAAREKRLEELRAERDE 796

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1424 EVEGEHERRLDKMKEE--HQQV-------MAKA-REQYEAEERKQRAELlghltGELERLQRAHERELetvrQEQHKRLE 1493
Cdd:COG3096    797 LAEQYAKASFDVQKLQrlHQAFsqfvgghLAVAfAPDPEAELAALRQRR-----SELERELAQHRAQE----QQLRQQLD 867

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1494 DLRRRhREQERKLQDL-----ELDLETRAKDVKARL-ALLEVQEETAR-----REKQQLLDVQRQVALKSEEATATHQQL 1562
Cdd:COG3096    868 QLKEQ-LQLLNKLLPQanllaDETLADRLEELREELdAAQEAQAFIQQhgkalAQLEPLVAVLQSDPEQFEQLQADYLQA 946

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1563 EEAQKE--------------HTHLLQS------------NQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEA 1616
Cdd:COG3096    947 KEQQRRlkqqifalsevvqrRPHFSYEdavgllgensdlNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKS 1026

                          570
                   ....*....|.
gi 1034572500 1617 EAQKKQHLLRE 1627
Cdd:COG3096   1027 SRDAKQQTLQE 1037
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1258-1544 7.72e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 7.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1258 QVQSSTQADEDQIRAEQEAsLQKLREELESQQKAERASLEQKNrQMLEQLKEEIEASEKSEQAALNAAKE-KALQQLREQ 1336
Cdd:COG4372     56 QAREELEQLEEELEQARSE-LEQLEEELEELNEQLQAAQAELA-QAQEELESLQEEAEELQEELEELQKErQDLEQQRKQ 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1337 LEGERKEAVATLeKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSS 1416
Cdd:COG4372    134 LEAQIAELQSEI-AEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESL 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1417 LLREKRQEVEGEHERRL--------DKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQ 1488
Cdd:COG4372    213 PRELAEELLEAKDSLEAklglalsaLLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAA 292

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1489 HKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDV 1544
Cdd:COG4372    293 LELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLV 348
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 1260-1461 7.74e-03

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 41.17  E-value: 7.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1260 QSSTQADEDQIRAE--QEAsLQKLREELEsQQKAERASLEQKnrqmLEQLKEEIEASEKSEQAALNAAkeKALQQLREQL 1337
Cdd:pfam05701  388 QAAQEAEEAKSLAQaaREE-LRKAKEEAE-QAKAAASTVESR----LEAVLKEIEAAKASEKLALAAI--KALQESESSA 459

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1338 EGERKEAVA---TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQqkeeaqlqkclgqvehrvhqksyhvagyEHEL 1414
Cdd:pfam05701  460 ESTNQEDSPrgvTLSLEEYYELSKRAHEAEELANKRVAEAVSQIEEAK----------------------------ESEL 511

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1415 SSLlrEKRQEVEGEHERRLDKMKEEHQQVmAKARE---QYEAEERKQRAE 1461
Cdd:pfam05701  512 RSL--EKLEEVNREMEERKEALKIALEKA-EKAKEgklAAEQELRKWRAE 558
PRK12705 PRK12705
hypothetical protein; Provisional
 1443-1597 7.86e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 41.23  E-value: 7.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1443 VMAKAREQY--EAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEdlRRRHREQERKLQDLELDLETRAKDV 1520
Cdd:PRK12705    23 VLLKKRQRLakEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARRE--REELQREEERLVQKEEQLDARAEKL 100

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034572500 1521 KARLALLEVQEETARREKQQLLDVQRQVALKSEEATAthqqleeaqkehthlLQSNQQLREILDELQArKLKLESQV 1597
Cdd:PRK12705   101 DNLENQLEEREKALSARELELEELEKQLDNELYRVAG---------------LTPEQARKLLLKLLDA-ELEEEKAQ 161
PTZ00491 PTZ00491
major vault protein; Provisional
 1296-1491 7.97e-03

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 41.16  E-value: 7.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1296 LEQKNRQMLEQ-LKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELErlcssLEAKHREVVSSL 1374
Cdd:PTZ00491   641 VDERTRDSLQKsVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLE-----LQAESAAVESSG 715

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1375 QKKiQEAQQKEEAQLQKClgqvehrvhQKSYHVAGyehelsslLREKRQEVEGEHErrLDKMKEEHQQvmakareqyEAE 1454
Cdd:PTZ00491   716 QSR-AEALAEAEARLIEA---------EAEVEQAE--------LRAKALRIEAEAE--LEKLRKRQEL---------ELE 766

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1034572500 1455 ERKQRAELlghltgELERlqrahERELETVRQEQHKR 1491
Cdd:PTZ00491   767 YEQAQNEL------EIAK-----AKELADIEATKFER 792
PTZ00491 PTZ00491
major vault protein; Provisional
 1262-1395 8.24e-03

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 41.16  E-value: 8.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1262 STQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKE--EIEASEKSEQAALNAAK------EKALQQL 1333
Cdd:PTZ00491   660 TTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAEsaAVESSGQSRAEALAEAEarlieaEAEVEQA 739

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1334 REQLEGERKEAVATLEKEHsAELErlcssLEAKHREVVSSL----QKKIQEAQQKEEAQLQKCLGQ 1395
Cdd:PTZ00491   740 ELRAKALRIEAEAELEKLR-KRQE-----LELEYEQAQNELeiakAKELADIEATKFERIVEALGR 799
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1264-1380 8.32e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 40.64  E-value: 8.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1264 QADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEeieasekseqaalnaAKEKALQQLREQLEGERKE 1343
Cdd:cd16269    188 QADQALTEKEKEIEAERAKAEAAEQERKLLEEQQRELEQKLEDQER---------------SYEEHLRQLKEKMEEEREN 252

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1034572500 1344 AVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQE 1380
Cdd:cd16269    253 LLKEQERALESKLKEQEALLEEGFKEQAELLQEEIRS 289
mukB PRK04863
chromosome partition protein MukB;
1476-1788 8.44e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 8.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1476 AHERELETVRQEQHK---RLEDLRRRHREQERKLQDLELDLEtrakDVKARLALleVQEETARREKQQlldvQRQVALks 1552
Cdd:PRK04863   290 ELRRELYTSRRQLAAeqyRLVEMARELAELNEAESDLEQDYQ----AASDHLNL--VQTALRQQEKIE----RYQADL-- 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1553 EEATAthqQLEEAQkehthllQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEA---QKKQHLLREVt 1629
Cdd:PRK04863   358 EELEE---RLEEQN-------EVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAiqyQQAVQALERA- 426

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1630 vEENNASPHFEPDlHIEDLRKSLgTNQTKEVSSSLSQSKEDLylDSLSSHNVWHLLSAEGV-----------ALRSAKEF 1698
Cdd:PRK04863   427 -KQLCGLPDLTAD-NAEDWLEEF-QAKEQEATEELLSLEQKL--SVAQAAHSQFEQAYQLVrkiagevsrseAWDVAREL 501

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1699 L---------VQQTRSMRRRQTALK---AAQQHWRHELASAQEVA-KDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGH 1765
Cdd:PRK04863   502 LrrlreqrhlAEQLQQLRMRLSELEqrlRQQQRAERLLAEFCKRLgKNLDDEDELEQLQEELEARLESLSESVSEARERR 581

                          330       340
                   ....*....|....*....|....*....
gi 1034572500 1766 NLLKKKEEKLNQLESSL------WEEASD 1788
Cdd:PRK04863   582 MALRQQLEQLQARIQRLaarapaWLAAQD 610
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1161-1345 8.59e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 8.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1161 EPVAPPEQLSEA--ALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQsLSSLRERLQKAie 1238
Cdd:COG4717    331 PPDLSPEELLELldRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEE-YQELKEELEEL-- 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1239 eeearmreeESQRLSWLRAQVQSSTQADEDQIRAE---QEASLQKLREELESQQKaERASLEQKNRQM-----LEQLKEE 1310
Cdd:COG4717    408 ---------EEQLEELLGELEELLEALDEEELEEEleeLEEELEELEEELEELRE-ELAELEAELEQLeedgeLAELLQE 477

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1034572500 1311 IE-----ASEKSEQAALNAAKEKALQQLREQLEGERKEAV 1345
Cdd:COG4717    478 LEelkaeLRELAEEWAALKLALELLEEAREEYREERLPPV 517
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
 1411-1624 8.86e-03

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


Pssm-ID: 463525 [Multi-domain]  Cd Length: 428  Bit Score: 40.84  E-value: 8.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1411 EHELSSLLREKRQEVEGE-HERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLghltgELERL-QRAHER---ELETVR 1485
Cdd:pfam12297  193 EKRMSSVFNKQFLAMEGRlQEEYERKMAALAAECNLETREKMEAQHQREMAEKE-----EAEELlKHADEQealECSSLL 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1486 QEQHK-RLEDLRR----RHREQERKLQdleldletRAKDVKARLALLEVQEEtarrekqQLLDVQRQVALKSEEATATHQ 1560
Cdd:pfam12297  268 DKLHKlEQEHLQRslllRQEEDFAKAQ--------RQLAVFQRVELHKIFFT-------QLKEATRKGELKPEAAKRLLQ 332

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034572500 1561 QLEEAQkehthllqsnQQLREILDELQARKLKLESqvdllqaqsqqlqKHFSSLEAEAQKKQHL 1624
Cdd:pfam12297  333 DYSKIQ----------EQIEELMDFFQANQRYHLS-------------ERFAQREYLVQSLQSL 373
PKK pfam12474
Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino ...
 1269-1336 9.43e-03

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.


Pssm-ID: 463600 [Multi-domain]  Cd Length: 139  Bit Score: 38.70  E-value: 9.43e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034572500 1269 QIRAEQEASLQKLREELESQQKAERASLEQ--------KNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ 1336
Cdd:pfam12474   55 RIRAEQKKRLKMFRESLKQEKKELKQEVEKlpkfqrkeAKRQRKEELELEQKHEELEFLQAQSEALERELQQLQNE 130
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1161-1624 9.52e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 40.89  E-value: 9.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1161 EPVAPPEQLSEAALKAMEEAVAQVlEQDQRHLLESKQEKMQQLrEKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEE 1240
Cdd:pfam07111  104 DALAVAEKAGQAEAEGLRAALAGA-EMVRKNLEEGSQRELEEI-QRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLNSL 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1241 EARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASL-QKLREELESQQKAE--RASLEQKNRQMLEQLKeEIEASEKS 1317
Cdd:pfam07111  182 ETKRAGEAKQLAEAQKEAELLRKQLSKTQEELEAQVTLvESLRKYVGEQVPPEvhSQTWELERQELLDTMQ-HLQEDRAD 260

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1318 EQAALNAAKEKaLQQLREQLEGERKEAVATLEKEHSAELE--RLCSSLEAKHREVVSSL--QKKIQEAQQKEE-AQLQKC 1392
Cdd:pfam07111  261 LQATVELLQVR-VQSLTHMLALQEEELTRKIQPSDSLEPEfpKKCRSLLNRWREKVFALmvQLKAQDLEHRDSvKQLRGQ 339

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1393 LGQVEHRVHQKSYHVAgyehELSSLLREKRQEVEGEH-ERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELE 1471
Cdd:pfam07111  340 VAELQEQVTSQSQEQA----ILQRALQDKAAEVEVERmSAKGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQI 415

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1472 RLQRAHERELETVRQ--EQHKRLE-DLRRRHREQ---ERKLQDLELDLET-----RAKDVKARLALlevqEETARREKQQ 1540
Cdd:pfam07111  416 WLETTMTRVEQAVARipSLSNRLSyAVRKVHTIKglmARKVALAQLRQEScppppPAPPVDADLSL----ELEQLREERN 491

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1541 LLDVQRQVALKSEEATATHQQlEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1620
Cdd:pfam07111  492 RLDAELQLSAHLIQQEVGRAR-EQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQ 570


                   ....
gi 1034572500 1621 KQHL 1624
Cdd:pfam07111  571 QQEI 574
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 1265-1344 9.73e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 41.09  E-value: 9.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572500 1265 ADEDQIRAEQEASLQKLREELESQ-----QKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEg 1339
Cdd:PRK11448   138 EDPENLLHALQQEVLTLKQQLELQarekaQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETSQERKQ- 216


                   ....*
gi 1034572500 1340 ERKEA 1344
Cdd:PRK11448   217 KRKEI 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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