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Conserved domains on  [gi|1034574900|ref|XP_016873606|]
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p53-regulated apoptosis-inducing protein 1 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPIP1 super family cl21181
p53-regulated apoptosis-inducing protein 1; TPIP1 is a family of eukaryotic proteins whose ...
 24-106 3.59e-41

p53-regulated apoptosis-inducing protein 1; TPIP1 is a family of eukaryotic proteins whose expression is induced by wild-type p53. Ectopically expressed TPIP1, which is localized within mitochondria, leads to apoptotic cell death through dissipation of mitochondrial A(psi)m. Phosphorylation of p53 Ser-46 regulates the transcriptional activation of TPIP1, thereby mediating p53-dependent apoptosis.


The actual alignment was detected with superfamily member pfam15338:

Pssm-ID: 464658  Cd Length: 123  Bit Score: 132.18  E-value: 3.59e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574900  24 GSSSEASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSDPLVLGAQVHGGCRGIEALSVSSGSWSSATVW 103
Cdd:pfam15338   1 GSSSEASFRSAQASCSGARRQGLGRGDQNLSVMLPNGRAQTHTLGWVSDLLVLGAQVHGGCRGIEALSVSSGSWSSATVW 80


                  ...
gi 1034574900 104 ILT 106
Cdd:pfam15338  81 CLT 83
 
Name Accession Description Interval E-value
TPIP1 pfam15338
p53-regulated apoptosis-inducing protein 1; TPIP1 is a family of eukaryotic proteins whose ...
 24-106 3.59e-41

p53-regulated apoptosis-inducing protein 1; TPIP1 is a family of eukaryotic proteins whose expression is induced by wild-type p53. Ectopically expressed TPIP1, which is localized within mitochondria, leads to apoptotic cell death through dissipation of mitochondrial A(psi)m. Phosphorylation of p53 Ser-46 regulates the transcriptional activation of TPIP1, thereby mediating p53-dependent apoptosis.


Pssm-ID: 464658  Cd Length: 123  Bit Score: 132.18  E-value: 3.59e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574900  24 GSSSEASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSDPLVLGAQVHGGCRGIEALSVSSGSWSSATVW 103
Cdd:pfam15338   1 GSSSEASFRSAQASCSGARRQGLGRGDQNLSVMLPNGRAQTHTLGWVSDLLVLGAQVHGGCRGIEALSVSSGSWSSATVW 80


                  ...
gi 1034574900 104 ILT 106
Cdd:pfam15338  81 CLT 83
 
Name Accession Description Interval E-value
TPIP1 pfam15338
p53-regulated apoptosis-inducing protein 1; TPIP1 is a family of eukaryotic proteins whose ...
 24-106 3.59e-41

p53-regulated apoptosis-inducing protein 1; TPIP1 is a family of eukaryotic proteins whose expression is induced by wild-type p53. Ectopically expressed TPIP1, which is localized within mitochondria, leads to apoptotic cell death through dissipation of mitochondrial A(psi)m. Phosphorylation of p53 Ser-46 regulates the transcriptional activation of TPIP1, thereby mediating p53-dependent apoptosis.


Pssm-ID: 464658  Cd Length: 123  Bit Score: 132.18  E-value: 3.59e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574900  24 GSSSEASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSDPLVLGAQVHGGCRGIEALSVSSGSWSSATVW 103
Cdd:pfam15338   1 GSSSEASFRSAQASCSGARRQGLGRGDQNLSVMLPNGRAQTHTLGWVSDLLVLGAQVHGGCRGIEALSVSSGSWSSATVW 80


                  ...
gi 1034574900 104 ILT 106
Cdd:pfam15338  81 CLT 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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