|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
5-431 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 731.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 5 PSAPLPQPLPPDGGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNY 84
Cdd:TIGR00892 2 PPALPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 85 GSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAP 164
Cdd:TIGR00892 82 GCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 165 FNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVSTAQKVNRFLDFSLFMHR 244
Cdd:TIGR00892 162 LNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFTHR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 245 GFLIYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTG 324
Cdd:TIGR00892 242 GFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 325 ICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKY 404
Cdd:TIGR00892 322 LTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKY 401
|
410 420
....*....|....*....|....*..
gi 1039732562 405 LYIASGTVVLVSGTYLLIGNAINYRLL 431
Cdd:TIGR00892 402 IFYASGSIVVSAGLFLAIGNYINYRLL 428
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
20-424 |
0e+00 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 562.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRPVGPspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLGP--------------------------------------LFKHRGFLIYLSGNVIMFLG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17427 203 FFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17427 283 VIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIW 362
|
....*
gi 1039732562 420 LLIGN 424
Cdd:cd17427 363 LFIGN 367
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
20-423 |
9.53e-180 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 508.26 E-value: 9.53e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRPVGPSPntkkskskvgsrhdstlkkaskvstaqkvnrFLDFSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPKP-------------------------------FLDLTLFTHRGFLLYLSGNVIMFFG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17426 210 LFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGF 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17426 290 CIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIY 369
|
....
gi 1039732562 420 LLIG 423
Cdd:cd17426 370 LFIG 373
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
20-424 |
8.51e-142 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 411.43 E-value: 8.51e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRPvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfLDFSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-------------------------------------LDFSVFRDRGFVIYTIAKFIMVLG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17430 204 LFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17430 284 VVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALF 363
|
....*
gi 1039732562 420 LLIGN 424
Cdd:cd17430 364 LALGN 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
20-422 |
9.40e-112 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 334.52 E-value: 9.40e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR------------------------------------------LLKDPTFVLLALGVSFAMLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtsLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17352 199 FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAD--KPRIGRLYLYIFTLLILGLSLLAFPLATTYVGL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17352 277 IVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVL 356
|
...
gi 1039732562 420 LLI 422
Cdd:cd17352 357 LFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
20-422 |
4.29e-105 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 317.48 E-value: 4.29e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRPvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP-----------------------------------------FCSNTRYQIYTLGVTWMVLG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17425 200 FVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17425 280 LVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALF 359
|
...
gi 1039732562 420 LLI 422
Cdd:cd17425 360 MGL 362
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
20-423 |
4.56e-84 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 264.25 E-value: 4.56e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRPVGPSPNTKKskskvgsrhdstlkkaskvsTAQKVNRFLDFSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPA--------------------PPRSLSAAFGLSLLTHRAFLRYALATTLINTG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIR-PRIQYLFSSaiiFTGICHLLCPLATTYSA 338
Cdd:cd17423 221 YFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRlLHLLVLWTA---LTGLSLLLLPLAKVYGS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 339 LVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLvSGT 418
Cdd:cd17423 298 LLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLL-LGS 376
|
....*
gi 1039732562 419 YLLIG 423
Cdd:cd17423 377 LILLT 381
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
20-420 |
6.95e-74 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 237.34 E-value: 6.95e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17422 161 LVVGALQLNIVVCGALLR------------------------------------------VLKEPGFICYALFGLFATLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRpRIQYLFSSAIIFtGICHLLCPLATTYSAL 339
Cdd:cd17422 199 FFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-KIYIELICVILL-CVVLLLFPFAYGFWSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 340 VVYVVFFGLGFGSISSLLFECLM--DIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSG 417
Cdd:cd17422 277 LVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGA 356
|
...
gi 1039732562 418 TYL 420
Cdd:cd17422 357 VFL 359
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
20-416 |
2.52e-54 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 186.18 E-value: 2.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLStLAPFNQYLFNNYGWKGSF 179
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFA-LAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRPVgpspntkkskskvgsrhdstlkkaskvstaqkvnrflDFSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI-------------------------------------DFSLLKDPFFCIYTWSFVFSQLA 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRpriQYLFSSA-IIFTGICHLLCPLATTYSA 338
Cdd:cd17421 203 YFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIK---KYHYHKAyLILCGVTNLLAPLATTYPL 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039732562 339 LVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVS 416
Cdd:cd17421 280 LMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLS 357
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
20-420 |
3.29e-54 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 185.78 E-value: 3.29e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17424 161 LILGGFVLNLCVCGALMR------------------------------------------FLLMPDFLVLAVSVLFLAYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSAL 339
Cdd:cd17424 199 CSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd17424 279 VPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLL 358
|
.
gi 1039732562 420 L 420
Cdd:cd17424 359 L 359
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
20-420 |
3.39e-41 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 151.91 E-value: 3.39e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNT-----TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGG 94
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 95 LLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYG 174
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 175 WKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVstaqkvnrfLDFSLFMHRGFLIYLSGNV 254
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHSRINLFLRKI---------FNVEIFKRKRYVIWALGIP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 255 ILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIqYLFSSAIIFTGICHLLCPLAT 334
Cdd:cd17420 232 LALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSIGLMSMMIPLCN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 335 TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVL 414
Cdd:cd17420 311 SFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPL 390
|
....*.
gi 1039732562 415 VSGTYL 420
Cdd:cd17420 391 IGSSLL 396
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
20-422 |
6.83e-35 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 133.80 E-value: 6.83e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR------------------------------------------LFTNKVFVAFIFWALFAYCS 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAF-LLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIftGICHLLCPLATTYS- 337
Cdd:cd17429 199 FVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTL--GVCILILPLMHTYTg 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 338 -ALVVYVVFFGLGFGSISSLLFEclmDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVS 416
Cdd:cd17429 277 lAIVCALIGFSSGYFSLMPVVTE---DLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVG 353
|
....*.
gi 1039732562 417 GTYLLI 422
Cdd:cd17429 354 IICLLL 359
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
20-420 |
4.45e-33 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 129.53 E-value: 4.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSS-----QIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGG 94
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDaqmrfKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 95 LLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYG 174
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 175 WKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKskvgsrhdstlKKASKVSTaqkVNRFLDFSLFMHRGFLIYLSGNV 254
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGK-----------KRKFKCPP---LKKIFNFNIWKSTGYRIWAFGIP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 255 ILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIqYLFSSAIIFTGICHLLCPLAT 334
Cdd:cd17464 227 AALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKV-YLQVSSFFFIGLMSMMIPLCH 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 335 TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVL 414
Cdd:cd17464 306 VFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPI 385
|
....*.
gi 1039732562 415 VSGTYL 420
Cdd:cd17464 386 IGGIIL 391
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
20-422 |
1.17e-30 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 121.85 E-value: 1.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17428 161 LIVGALALNLLACGSLMR------------------------------------------LFKNRVFSALFIAILLFDIG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHIGVDDYNSAF-LLSVMAFIDMFARPSVGLIANTSLIRPriQYLFSSAIIFTGICHLLCPLATTYSA 338
Cdd:cd17428 199 AFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSYLT 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 339 LVVYVVFFGLGFGSISSLLFeCLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGT 418
Cdd:cd17428 277 LAVLSAILGFLSGNWSIFPY-VTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGF 355
|
....
gi 1039732562 419 YLLI 422
Cdd:cd17428 356 LLLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-416 |
6.74e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 117.67 E-value: 6.74e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIG 100
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 101 MILASYSNSvIELYLTVGFIGGLGLAFNLQPALTIIGKYFY-RRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:COG2223 84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLhscVAGCLMRPVGPSPNTKKSKSKVGSRHDStlkkaskvstaqkvnrfldFSLFMHRGFLIYLSGNVILFLG 259
Cdd:COG2223 163 LILGILLL---VVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------------LEALRDPRFWLLSLLYFGTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAK-HIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtslirpRIQYLFSSAIIFTGICHLLCPLATTYSA 338
Cdd:COG2223 221 FIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSD------RIGGRRVLLIVFALMALGLLLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 339 LVVYVVFF---GLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLV 415
Cdd:COG2223 295 LWLFLVLFlllGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV 374
|
.
gi 1039732562 416 S 416
Cdd:COG2223 375 A 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-417 |
1.79e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 113.04 E-value: 1.79e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 17 GGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLL 96
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 97 CCIGMILASYSNSVIELYLTVgFIGGLGLAFNLQPALTIIGKYFY-RRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGW 175
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 176 KGSFLILGGIFLhscVAGCLMrpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfslfmhrgFLIYLSGNVI 255
Cdd:COG2271 164 RAAFLILGLPGL---LLALLR-------------------------------------------------FWLLALAYFL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 256 LFLGIFAPIIFLAQYAKHI-GVDDYNSAFLLSVMAFIDMFARPSVGLIANtsLIRPRIQYLFSSAIIFTGICHLLCPLAT 334
Cdd:COG2271 192 VYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD--RLGRRRKLVLAIGLLLAALALLLLALLP 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 335 TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIASGTVVL 414
Cdd:COG2271 270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALAL 348
|
...
gi 1039732562 415 VSG 417
Cdd:COG2271 349 LAA 351
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-389 |
4.71e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 108.66 E-value: 4.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 22 VVVCASFISIGFSYAFPkavtVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGM 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGP----ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 102 ILASYSNSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFL 180
Cdd:pfam07690 77 LLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 181 ILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSrhdstlkkaskvstaqkvnRFLDFSLFMHRGFLIYLSGNVILFLGI 260
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------LIVAWKALLRDPVLWLLLALLLFGFAF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 261 FAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIqYLFSSAIIFTGICHLLCPLATTYSALV 340
Cdd:pfam07690 217 FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL-LLALLLLILAALGLLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1039732562 341 VYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGP 389
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
20-421 |
1.73e-24 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 104.66 E-value: 1.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPA-LTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGS 178
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 179 FLILGGIFLHSCVAGCLMRPVGPSPntkkskskvgsrhdstLKKASKVSTAQKVNRFLDFSLFMHRGFLIYLSGNVILFL 258
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPAD----------------LALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 259 GIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGichLLCPLATTYSA 338
Cdd:cd17355 225 AVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLA---LLLLLPFPPLA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 339 LVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGT 418
Cdd:cd17355 302 LLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
...
gi 1039732562 419 YLL 421
Cdd:cd17355 382 LVL 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-380 |
6.61e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.36 E-value: 6.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 14 PPDGGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVG 93
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 94 GLLCCIGMILASYSNSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNN 172
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 173 YGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVgsrhdstlkkaskvstaqkvnrfldFSLFMHRGFLIYLSG 252
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-------------------------RELLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 253 NVILFLGIFAPIIFLAQYAKHI-GVDDYNSAFLLSVMAFIDMFARPSVGLIANtsliRPRIQYLFSSAIIFTGICHLLCP 331
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGRRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1039732562 332 LATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIV 380
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-420 |
5.77e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 100.72 E-value: 5.77e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 5 PSAPLPQPLPPDGGWGWVVVCASFISIGFSYAFPkAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNY 84
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAIT-SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 85 GSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIG-GLGLAFNLQPALtiIGKYFYRRRPLANGCAMAGSPVFLSTLA 163
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGaGIAVGNVLLPGL--IKRWFPDRVGLMTGLYTAAMGLGAALAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 164 PFNQYLFNNYGWKGSFLILGGIflhSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKAskvstaqkvnRFLDFSLFMh 243
Cdd:COG2807 159 GLTVPLAAALGWRGALAVWALL---ALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSP----------LAWLLTLFF- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 244 rgfliylSGNVILFLGIFApiiFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtSLIRPRIQYLFSSAIIFT 323
Cdd:COG2807 225 -------GLQSLLYYAVVA---WLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD-RLGDRRPLLLLLGLLGLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 324 GICHLLcpLATTySALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAvgLTTIVECCPVL---FGPPLAGKLLDITG 400
Cdd:COG2807 294 GLLGLL--LAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAA--LSGMAQSVGYLlaaLGPLLVGALHDATG 368
|
410 420
....*....|....*....|...
gi 1039732562 401 EYK---YLYIASGTVVLVSGTYL 420
Cdd:COG2807 369 SWTaalLLLAALAVLMLVAGLLA 391
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
19-417 |
1.38e-21 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 96.53 E-value: 1.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 19 WGWVVVCasfISIGFSYAFpkavTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCC 98
Cdd:cd17353 7 LGAVLMH---LILGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 99 IGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANG---CAMAGSPVFLStlaPFNQYLFNNYGW 175
Cdd:cd17353 80 LGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGiviAGFGLGSLIFS---PLIAYLINTVGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 176 KGSFLILGGIFL-HSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVSTAQKvnrfldfslfmhRGFLIYLSgnv 254
Cdd:cd17353 157 PTTFLILGIIFLiIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTP------------TFWLLWLM--- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 255 iLFLGIFAPIIFLAQYA----KHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtsliRPRIQYLFSSAIIFTGICHLLC 330
Cdd:cd17353 222 -FFLNATAGLMLIGQAKpigqEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSD----KIGRKNTLSIAFLIQGVAMFLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 331 PLAT-TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGkLLDITGEYKYLYIAS 409
Cdd:cd17353 297 PFIGsVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIA 375
|
....*...
gi 1039732562 410 GTVVLVSG 417
Cdd:cd17353 376 AALSLVAL 383
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
20-421 |
2.45e-20 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 92.55 E-value: 2.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQ-----IAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGG 94
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQavqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 95 LLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYG 174
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 175 WKGSFLILGGIFLHSCVAGclmrpvgpspntkkskskvgsrhdstlkkaskvstaqkvnrfLDFSLFMHRGFLIYLSGNV 254
Cdd:cd17465 161 LAHTFQVLSLFMFIQIFLS------------------------------------------LTYKVFRRKTYRIWAFGIA 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 255 ILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtSLIRPRIQYLFSSAIIFTGICHLLCPLAT 334
Cdd:cd17465 199 TAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGD-LIPGLKKIYLQVASFLLLGIMSMMIPLCQ 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 335 TYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVL 414
Cdd:cd17465 278 VFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPI 357
|
....*..
gi 1039732562 415 VSGTYLL 421
Cdd:cd17465 358 IGGTVLF 364
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
20-423 |
4.16e-20 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 92.09 E-value: 4.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 20 GWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLHSCVAGCLMRPVGPSPNTKKSkskvgsrhdstlkkaskvstaQKVNRFLDFSLFMHRGFLIYLSGNVIL--F 257
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARL---------------------HVQKKKTQTMGEIFRDKVFWILFIAIFlvL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 258 LGIFAPIIFLAQYAKHIGVDDYN-SAFLLSVMAFIDMFARPSVGLIANTsLIRPRIQYLFSSAIIFTGICHLLCPLATTY 336
Cdd:cd17314 220 IGGFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVADF-FGGRLSTLSILLTILGLGLCAFLFLLKMTP 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 337 SALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVS 416
Cdd:cd17314 299 VGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLA 378
|
....*..
gi 1039732562 417 GTYLLIG 423
Cdd:cd17314 379 SAILLAV 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-421 |
6.41e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.17 E-value: 6.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 24 VCASFISIGFSYAfpkAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMIL 103
Cdd:cd06174 1 LLLGFFLTGLARG---LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 104 ASYSNSVIELYLTvGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLF--NNYGWKGSFL 180
Cdd:cd06174 78 FAFAPSFWLLLLG-RFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 181 ILGGIFLHSCVAGCLMRPvgpspntkkskskvgSRHDSTLKKASKVSTAQKVNRFldFSLFMHRGFLIYLSGNVILFLGI 260
Cdd:cd06174 157 IAAALALLAAILLLLVVP---------------DPPESARAKNEEASSKSVLKLL--KRVLKNPGLWLLLLAIFLVNLAY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 261 FAPIIFLAQYAK-HIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFssaIIFTGICHLLCPLATTYSAL 339
Cdd:cd06174 220 YSFSTLLPLFLLdLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG---LLLMALGLALLLLAPSLLLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 340 VVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTY 419
Cdd:cd06174 297 LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
..
gi 1039732562 420 LL 421
Cdd:cd06174 377 LL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
55-423 |
8.37e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 75.69 E-value: 8.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 55 TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVgFIGGLGLAFNLQPALT 134
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 135 IIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVG 213
Cdd:cd17325 108 LIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 214 SRHDstlkkaskvstaqkvnrfldFSLFMHRGFLIYLSGNVILFLGIFAPII-FLAQYAKH-IGVDDYNSAFLLSVMAFI 291
Cdd:cd17325 188 LRSG--------------------LRLLLRDRRLLALFLAIFVLAFAFGALEpFLPLYAAElGGLSPAQIGLLFGAQGLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 292 DMFARPSVGLIANTsliRPRIQYLFSSAIIfTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFS 371
Cdd:cd17325 248 SALSQPPAGKLSDR---IGRKPLILIGLLL-SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1039732562 372 SAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIASGTVVLVSGTYLLIG 423
Cdd:cd17325 324 TAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
75-416 |
1.59e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 68.77 E-value: 1.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 75 PISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRpLANGCAMAG 154
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 155 SPVFLSTL--APFNQYLFNNYGWKGSFLILGGIFLHSCVAgCLMRPVGPSPNTKKSKSKVGSRHDSTLKKAskvstaqkv 232
Cdd:cd17489 127 LATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLALLALLL-VFLVKDPPPVAAEEAEAGTRAFRRLVEKKV--------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 233 nrfLDFSLFMhrgFLIYLSGNVILFlgifapiiFLAQYAKHIGVDdyNSAFLLSVMAFIDMFARPSVGLIANTslIRPRI 312
Cdd:cd17489 197 ---LPPALIL---FLASIAYGAIST--------FLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDR--KGPKT 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 313 QYLFSSAIIFTGICHLLcpLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLA 392
Cdd:cd17489 259 VIIPGLLLLALGLLLLS--FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLL 336
|
330 340
....*....|....*....|....
gi 1039732562 393 GKLLDITGeYKYLYIASGTVVLVS 416
Cdd:cd17489 337 GLVAELFG-YRAMFLLAAVVVLLA 359
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-400 |
2.13e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 2.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 22 VVVCASFISIGFSYAfpkAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGM 101
Cdd:COG0738 11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 102 ILASYSNSVIeLYLTVGFIGGLGLAF---NLQPALTIIGKYFYRRR-PLANGCAMAGS---PVFLSTLAPFNqylfNNYG 174
Cdd:COG0738 88 LLFALAPSYP-LLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLHAFFSLGAllgPLLGGLLILLG----LSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 175 WKGSFLILGGIFLhsCVAGCLMRpvGPSPNTKKSKSKVGSRHDSTlkkaskvstaqkvnrfldFSLFMHRGFLIYLsgnV 254
Cdd:COG0738 163 WHLPYLILAVLLL--LLALLFLR--SKLPEIEEEEEEAAGSAASL------------------KSLLKNPRLLLGG---L 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 255 ILFLGIFA---PIIFLAQYAKHI-GVDDYNSAFLLSVMAFIDMFARPSVGLIANtsLIRPRIQYLFSSAIIFTGIchLLC 330
Cdd:COG0738 218 AIFLYVGAegaIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLK--RFGPVRLLRLSALLAAVGL--LLA 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 331 PLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRfSSAVGLTTIVECCPVLFGPPLAGKLLDITG 400
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFG 362
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
45-414 |
1.90e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.20 E-value: 1.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 45 FKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELyLTVGFIGGLG 124
Cdd:cd17474 22 LPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 125 LAFNLQPALTIIGKYF---YRRRPL-----ANGCAMAGSPVFLSTLApfnqylfnNYGWKGSFLILGGIFLHSCVAgcLM 196
Cdd:cd17474 101 AAGLGPLALTLIGDLFeggERAKAMglyeaALGLGIAVGPLLGGLLA--------AISWRYPFFLLAALIPVAFLA--IL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 197 RPVGPSPNTKKSKSKVGSRHdstlkkaskvstaqkvnrflDFSLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKHigv 276
Cdd:cd17474 171 FLLPEPKEKAKSSSATKLRD--------------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLEL--- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 277 DDYNSAFLLSVMAFIdmfarPSVGLIANTSLIRPRIQYLFSS------AIIFTGICHLLCPLATTYSALVVYVVFFGLGF 350
Cdd:cd17474 228 LYGISPIIIGLLFAG-----WSVLLALGSLFVGRLLKKRFGArrilviGLLLYALSLLLLGFVPSLALLLIAIVLFGLGL 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039732562 351 GSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVL 414
Cdd:cd17474 303 GLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-369 |
1.35e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.87 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 47 DIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFIGGLGLA 126
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 127 FNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILGGIFLhsCVAGCLMRPVGPSPNT 205
Cdd:cd17324 103 GFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 206 KKSKSKVGSRHDSTLKKAskvstaqkvnrfldfslfmhRGFLIYLSGnVILFLGIFAPIIFLAQYAKHI-GVDDYNSAFL 284
Cdd:cd17324 181 KPGSLGLLSSLLLLLRNP--------------------RLRLAYLIT-FLLFGGFFALYTYLAPFLTDVpGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 285 LSVMAFIDMFARPSVGLIANTSLIRPriqyLFSSAIIFTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDI 364
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
....*
gi 1039732562 365 VGATR 369
Cdd:cd17324 316 APEAR 320
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-416 |
2.61e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 58.79 E-value: 2.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 48 IQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFIGGLGLAf 127
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-YPVLLVLLFLVGAGYG- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 128 NLQPALT--IIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNT 205
Cdd:cd17475 100 SVQPGGGraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 206 KKSkskvgsrhdstlKKASKVSTAQKVNRFLDFslfmhrgFLIYLSGnVILFLGIFAPIIFLAQYAK-HIGVDDYNSAFL 284
Cdd:cd17475 180 ATE------------SASTLLRSLKEVLRNRDV-------WLIAIAG-ALLVAPQFALLTFLLLFLHdHLGLSVVAAGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 285 LSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTG--ICHLLCPLATTYSALVVYVVFFGL---GFGSISSLLfe 359
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAalLVLSLLSPGTPLWLLVLLLILLGLfaiGWNGLYLTL-- 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1039732562 360 cLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVS 416
Cdd:cd17475 318 -VAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLA 373
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
40-351 |
5.07e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.97 E-value: 5.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 40 AVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELyLTVGF 119
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 120 IGGLGLAFNLQPALTIIGKYFYRRRpLANGCAMAGSPVFLS-TLAP-FNQYLFNNYGWKGSFLILGGIflhsCVAGCLMR 197
Cdd:cd17503 93 LQGFGGGVLIPLAQTILLRIYPPEK-RGAAMGLVGLVILLApAIGPtLGGWLTDNLSWRWIFYINLPI----GILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 198 PvgpspntkkskskvgsrhdstlkkaskvstaqkvnrFLDFSLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKHI-GV 276
Cdd:cd17503 168 P------------------------------------LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVlGY 211
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039732562 277 DDYNSAFLLSVMAFIDMFARPSVGLIANTslIRPRIqYLFSSAIIFTGICHLLCPLATTYSALVVYVVFFGLGFG 351
Cdd:cd17503 212 SAFESGLVLAPGGLASAILSPLVGRLLDK--FGPRL-LLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLG 283
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-187 |
1.08e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 56.36 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 19 WGWVVVCASFISIGFSYAfpkAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCC 98
Cdd:COG0477 14 RALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 99 IGMILASYSNSVIELYLTVgFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKG 177
Cdd:COG0477 91 LASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170
....*....|
gi 1039732562 178 SFLILGGIFL 187
Cdd:COG0477 170 IFLINAPLGL 179
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
244-422 |
2.09e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.75 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 244 RGFLIYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtslIRPRIQYLFSSAIIFT 323
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD---RFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 324 gICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGeYK 403
Cdd:COG2814 87 -LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WR 164
|
170
....*....|....*....
gi 1039732562 404 YLYIASGTVVLVSGTYLLI 422
Cdd:COG2814 165 WVFLVNAVLALLALLLLLR 183
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
52-186 |
3.10e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 55.44 E-value: 3.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 52 FNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELyLTVGFIGGLGLAFNLQP 131
Cdd:TIGR00895 47 WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL-LILRFLAGLGLGGLMPN 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039732562 132 ALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLIlGGIF 186
Cdd:TIGR00895 126 LNALVSEYApKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV-GGIA 180
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-400 |
3.94e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 3.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 60 AWISSIMLAVMYAGG---PISSVLVNNYGSR-----PVVIVGGLLCCIGMILA----SYSNSVIELYLTVGFIG-GLGLA 126
Cdd:COG2211 46 ALVGLILLVARLWDAitdPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLftapDLSPTGKLIYALVTYLLlGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 127 FNLQPALTIIGKYF--YRRRPLANG----CAMAGSPVFLSTLAPFNQYLFNN--YGWKGSFLILGGIFLHSCVAGCLMRP 198
Cdd:COG2211 126 LVNIPYSALGAELTpdYEERTRLSSwrfaFAGLGGLLASVLPPPLVAAFGGDaaLGYRLTALIFAVLGLLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 199 VGPSPNTKKSKSKVGSRhdstlkkaskvstaqkvnrfldfSLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKH-IGVD 277
Cdd:COG2211 206 ERPVPEEEKVSLKESLK-----------------------ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 278 DYNSAFLLSVMAFIDMFARPSVGLIANtslirpRI--QYLFSSAIIFTGICHLLCPLA--TTYSALVVYVVFFGLGFGSI 353
Cdd:COG2211 263 AALVGLLLALYFLAALLGAPLWPRLAK------RFgkKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAI 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1039732562 354 SSLLFECLMDIV-------GATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITG 400
Cdd:COG2211 337 LVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
74-422 |
9.54e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 9.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 74 GPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFIGGLGLAFNLQPALTIIGKYF---YRRRPLA-NG 149
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS-LYALLASRALLGIGVAGIMTLATALIGDYFegeERAKMLGlQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 150 CAMAGSPVFLSTLAPFnqylFNNYGWKGSFLI-LGGIFLHSCVAGCLmrpvgpsPNTKKSKSKVGSRHDSTLKKASKVST 228
Cdd:cd17473 131 AAMSLGGVVFLLLGGA----LAEIGWRAPFLVyLLALPVLILVLLFL-------PEPARKSKSAASPGAATAAALPWKRV 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 229 aqkvnrfldfslfmhrgFLIYLSGnVILFLGIFAPIIFLAQYAKHIGVDDYNSA-FLLSVMAFIDMFARPSVGLIANtsl 307
Cdd:cd17473 200 -----------------LPIYFLA-FLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKR--- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 308 iRPRIQYLFSSAIIFTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVeccpVLF 387
Cdd:cd17473 259 -RLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA----FFL 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 1039732562 388 G----PPLAGKLLDITGEYKYLYIASGTVVLVSGTYLLI 422
Cdd:cd17473 334 GqflsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
250-416 |
1.35e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 250 LSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTslIRPRIQYLFSSAIifTGICHLL 329
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLI--FALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 330 CPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIAS 409
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVA 156
|
....*..
gi 1039732562 410 GTVVLVS 416
Cdd:cd17489 157 AVLALLA 163
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-421 |
2.31e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 49.63 E-value: 2.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 24 VCASFISIGFSYAFpkaVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMIL 103
Cdd:cd17333 1 LYISFFSNGLTDAL---LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 104 ASYSNSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRP----LANGCAMAGSPVFLSTLAPFnqyLFNNYGWKGSF 179
Cdd:cd17333 78 IFATPSIY-LFVVLMFLAGLGAGILDTGANTFVGALFEESSAtrlnVLHGFFGLGALIGPLIATSL---LTSELSWSWAY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGGIFLhsCVAGCLMRPvgpspntkKSKSKVGSRHDSTLKKASKVSTAQKvnrfldfslfmhRGFLIYLSGNVILFLG 259
Cdd:cd17333 154 LIIGLIYL--LLAILILLT--------LFPELPSARNPQQSVGAFSASASRL------------LRNPSIILGALALFLY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIF------LAQYAKHIGVDDynSAFLLSVMAFIDMFARPSVGLIANTslIRPRIQYLFSSAIIFTGichlLCPLA 333
Cdd:cd17333 212 VGAETAFsswvpsYLVEKKHVSDGL--AGYLLSGFWVGITIGRLLGGPISRR--IKPHTLLVLSGSGALLG----LLILL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 334 TTYSALVVYVVFFGLGFGsiSSLLFECLMdIVGATRF----SSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIAS 409
Cdd:cd17333 284 LAPTLVVGLVATALLGLF--MAALFPTIL-SLGISNLpyakGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLIT 360
|
410
....*....|..
gi 1039732562 410 GTVVLVSGTYLL 421
Cdd:cd17333 361 ILYAIIFVLALL 372
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
45-363 |
1.33e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.19 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 45 FKDIQEIFNTTSSQIAWISSIMLAVMYAG----GPISSVlvnnYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFI 120
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGqllyGPLSDR----FGRRPVLLAGLLLFILASLLCALASS-IEQLLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 121 GGLGLAFNLQPALTIIGKYfYRRRPLANGCAMAGSPVFLS-TLAP-FNQYLFNNYGWKGSFLILGGIFLhSCVAGCLMRP 198
Cdd:cd17320 97 QGLGAAAGSVVARAIVRDL-YSGAELAKIFSLLMMILAIApALAPlLGGLLLLFFGWRAIFVFLALLGL-LLLLLVLLFL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 199 VGPSPNTKKSKSKVGSRHDStlkkaskvstaqkvnrfldFSLFMHRGFLIYLSGNVILFLGIF-----APIIFLAQYakH 273
Cdd:cd17320 175 PETLPEEKRKPLLSSLLRAY-------------------KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQL--G 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 274 IGVDDYNSAFLLSVMAFIDMfarpsvGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLAT-----TYSALVVYVVFFGL 348
Cdd:cd17320 234 LSPAQFGLLFALNAIALILG------SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAllgglSLWPLVAPLFLIFF 307
|
330
....*....|....*
gi 1039732562 349 GFGSISSLLFECLMD 363
Cdd:cd17320 308 GFGLIFPNATSLALE 322
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-198 |
1.56e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 21 WVVVCASFISIGFSYAFpkaVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSR--PVVIVGGLLCC 98
Cdd:COG2271 183 WLLALAYFLVYFALYGF---LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 99 IGMILASYSNSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKG 177
Cdd:COG2271 260 LALLLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 1039732562 178 SFLILGGIFLHSCVAGCLMRP 198
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
47-376 |
1.75e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.78 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 47 DIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELylTVG-FIGGLGL 125
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL--IAArALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 126 AFNLQPALTIIGKYFY-RRRPLA---NGCAMAGSPVFLSTLAPFnqyLFNNYGWKGSFLILGGIflhsCVAGclmrpvgp 201
Cdd:cd17321 99 AAIMPASLALIAATFPgERRGRAlglWGAVVGIGAALGPLLGGL---LLELFGWRWIFLINVPI----GLVA-------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 202 spntkkskskvgsrhdstlkkaskvstaqkvnrfldfsLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKHI-GVDDYN 280
Cdd:cd17321 164 --------------------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVlGYSPLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 281 SAFLLSVMAFIDMFARPSVGLIANTslIRPRIQYLFSSAIIFTGICHL-LCPLATTYSALVVYVVFFGLGFGSISSLLFE 359
Cdd:cd17321 206 AGLALLPLALAMLVAAPLAGRLADR--FGPRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPLTN 283
|
330
....*....|....*..
gi 1039732562 360 CLMDIVGATRFSSAVGL 376
Cdd:cd17321 284 AALSSVPKEKAGAASGI 300
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
48-378 |
2.76e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 48 IQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGfIGGLGLAF 127
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA-LQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 128 nLQPALTIIGKYFYRRR-PLANGcAMAGSPVFLSTLA-PFNQYLFNNYGWKGSFLILGGIflhsCVAGCLMRPvgpspnt 205
Cdd:cd17504 101 -FPLAFALVREEFPPERvPVAQG-ILSATFGIGAGIGlPLGGWIVQHLGWRWIFWTAAPV----AVLLAALVP------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 206 kkskskvgsrhdstlkkaskvstaqkvnrFLDFSLFMHRGFLIYLSGNVILFLGIFA---PIIFLAQYAKHIGV--DDYN 280
Cdd:cd17504 168 -----------------------------LIDLRLLRRRNVLLANITALLAGFGMFMvfqLLPQLLQLPTPTGFglGITE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 281 SAFLLSVMAFIDMFARPSVGLIAntSLIRPRIQYLFSSAIIFTGIChLLCPLATTYSALVVYVVFFGLGFGSISSLLFEC 360
Cdd:cd17504 219 AGLLLLPGALVMLIAGPLAGRLI--ARVGPRRVLLIGLVISAVGLL-LLALLHSSLWALVVALLLIGIGLGLAFASLPNI 295
|
330
....*....|....*...
gi 1039732562 361 LMDIVGATRFSSAVGLTT 378
Cdd:cd17504 296 VVESVPPDRTGIATGMNT 313
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-422 |
4.15e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 45.64 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIG 100
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 101 MILASYSNSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSF 179
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 180 LILGgiflhscVAGCLMRPVgpspntkkskskvgsrhdstlkkaskvstaqkvnrfldfSLFMHRGFLIYLSGNVILFLG 259
Cdd:cd17319 161 IIEG-------LLGLLLAVL---------------------------------------WWFYLRQVWGLALGYFGINYA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 260 IFAPIIFLAQYAKHI-GVDDYNSAFLLS---VMAFIDMFArpsVGLIANTSLIRPRIQYLFSSAiIFTGICHLLCPLATT 335
Cdd:cd17319 195 LYGLLTWLPTYLKQArGFSLKQVGLLAAipfLAGAIGMIL---GGRLSDRLLRGARRLVIIIGL-LLAAVGLLLAYLTTS 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 336 YSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLV 415
Cdd:cd17319 271 PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350
|
....*..
gi 1039732562 416 SGTYLLI 422
Cdd:cd17319 351 AALLVLL 357
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
52-184 |
9.16e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.50 E-value: 9.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 52 FNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTvGFIGGLGLAFNLQP 131
Cdd:cd17365 29 WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL-RFLTGLGLGAAMPN 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1039732562 132 ALTIIGKYF-YRRRPLANGCAMAGSPV---FLSTLAPFnqyLFNNYGWKGSFLILGG 184
Cdd:cd17365 108 AITLVSEYApARRRSLAVTLMFCGYPLgaaLGGFLAAA---LIPAFGWRSVFLLGGV 161
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-136 |
1.91e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.72 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEI-FNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLPTPTgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110
....*....|....*....|....*....|....*..
gi 1039732562 100 GMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTII 136
Cdd:cd17504 260 GLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
55-186 |
2.09e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.77 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 55 TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIG-GLGLAFNLQPAL 133
Cdd:cd06179 30 PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGiGAGTQGLGAAVA 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1039732562 134 T-IIGKyfyRRRPLANGCAMAGSPVFlSTLAPF-NQYLFNNY--GWKGSFLILGGIF 186
Cdd:cd06179 110 SeLVPN---KYRGLVQGVVNLVASPG-SALGPLiAGALVEANaaGWRWIFYINAIFN 162
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-422 |
3.71e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 21 WVVVCASFI-SIGFSYAFPkAVTVFFKDIQEIfntTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17329 2 WVLLIGSFLnRLGFFMVWP-FMAIYLHQQLGL---SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIEL---YLTVGFIGGLglafnLQPAL-TIIG--------KYFYRRRPLANGCAMAGSPVFLSTLApfnq 167
Cdd:cd17329 78 GFALLGFAHSPWLFaiaLVLTGFGGGL-----FEPASeAMIAdvttpenrTRAFSLLYWAINLGVAIGPLLGGLLL---- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 168 ylfnNYGWKGSFLILGGIFLhsCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKAskvstaqkvnrfldfslfmHRGFL 247
Cdd:cd17329 149 ----LYSFRLLFLAAAVLFL--LAALVLLFLLPETRPKRRAAEKTEILRGYKIVLR-------------------DRAFL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 248 IYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNS-AFLLSVMAFIDMFARPSVGLIANtsliRPRIQYLFSSAIIFTGIC 326
Cdd:cd17329 204 LFLLASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLVE----RFRLRKILMIGILLFAIG 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 327 HLLCPLATTYSALVVYVVFFGLG---FGSISSLLFECLMDIVGATRFSSAVGLTTIVEccpVLFGPPLAGKLLDITGEYK 403
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTLGemlVFPAVQTLVAALAPPDKRGSYMGFYALAWGLG---RAIGPLVGGLLLDLLGPGL 356
|
410
....*....|....*....
gi 1039732562 404 YLYIASGTVVLVSGTYLLI 422
Cdd:cd17329 357 PWLILAALGLIAAALLLGL 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
250-422 |
4.17e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 250 LSGNVILFLGIFAPIIFLAQY-AKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANtsLIRPRIQYLFSsaIIFTGICHL 328
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIG--LLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 329 LCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIA 408
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 1039732562 409 SGTVVLVSGTYLLI 422
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
49-187 |
1.14e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.02 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 49 QEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVgFIGGLGLAFN 128
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL-ALLGLGLGLV 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039732562 129 LQPALTIIGKYFYRRR-----PLANGC---AMAGSPVFLStlapfnqYLFNNYGWKGSFLILGGIFL 187
Cdd:cd17325 306 FPATLALLADIVPPEGrgtamGLFNTAfslGMVLGPLLGG-------FLYDAFGFATPFLAAAALLL 365
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
22-187 |
2.23e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 40.32 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 22 VVVCASFISIGFSYAFPKAVTVFFKD-IQEIF------NTTSSQIAWISSIMLAVMYAGG----PISSVLVNNYGSRPVV 90
Cdd:cd17357 3 IVAFGGSFQFGYNIGVVNAPQEVFKEfINDTLvdryglNLSDSELDLLWSLIVSIFFIGGaigsFISAFLANRFGRKNGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 91 IVGGLLCCIG--MILASYSNSVIELYLTVGFIGGLglafnlqpaltiigkyfyrrrplANGCAMAGSPVFLSTLAPfnqy 168
Cdd:cd17357 83 LISNALLVVSslLMFLSKSAKSPELLIFGRFLVGI-----------------------ACGLSTGFVPMYLQEISP---- 135
|
170
....*....|....*....
gi 1039732562 169 lfnnYGWKGSFLILGGIFL 187
Cdd:cd17357 136 ----SELRGALGSLTQIGV 150
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
74-183 |
2.26e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.40 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 74 GPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTvGFIGGLGLAFNLQPALTIIGKYFYR-RRPLANGCAM 152
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAFALVAGAALIADIYPPeERGVALGLMS 93
|
90 100 110
....*....|....*....|....*....|.
gi 1039732562 153 AGSPVFLSTLAPFNQYLFNNYGWKGSFLILG 183
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLA 124
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-357 |
3.72e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.46 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 48 IQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSvIELYLTVGFIGGLGLAF 127
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN-YWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 128 NLQPALTIIGKYFYRRRPLANGCAMAG-------SPVFLStlapfnqYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVG 200
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGgnlgfalGPLIAA-------ALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 201 PSPNTKKSKskvgsrhdstlkKASKVSTAQKVNRFLDFSLFMhrGFLIYLSGNVIlflgifapIIFLAQYAKHIGVDDYN 280
Cdd:cd17478 174 KPEAKKAAA------------KSSARSTLKGVWRALLLLLII--VFLRSWVLSSL--------TTFLPFYLVQRGYSLVF 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039732562 281 SAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTgichLLCPLATTYSALVVYVVFFGLGFGSISSLL 357
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFL----LLFLLTPGIWSYILLVLAGFLLFASFPVTV 304
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
21-185 |
3.78e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.56 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 21 WVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAvMYAGGP-ISSVLVNNYGSRPVVIVGGLLCCI 99
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLI-AYAVGKfISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 100 GMILASYSNSVIELYLTVGFIG---GLGLAfnlqPALTIIGKYFYRRR-----PLANGCAMAGSpvFLSTLapFNQYLFN 171
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGlfqSMGWP----PCVKLLGNWFSKKErgtvyGIWSTSHNFGG--ILAPI--LAASLAS 152
|
170
....*....|....
gi 1039732562 172 NYGWKGSFLILGGI 185
Cdd:cd17312 153 YYGWRAAFLVPGIV 166
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
221-422 |
5.48e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 221 KKASKVSTAQKVNRFLDFslfMHRGFLIYLSgnvilFLGIFAPII-------FLAQYAKHIGVddynSAFLLSVMAFIDM 293
Cdd:cd17490 173 ERREKKPVLTELKELLSV---LKDKKLLFFS-----LLAILQQMItfsttfgFTPLIAKQLGA----SSFQLGLLSIIYL 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 294 FARPSVGLIANTSLIRPRIQY--LFSSAIIfTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFS 371
Cdd:cd17490 241 LPNALASLLSGTLFYKKLGERntIIIGFLL-LGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRS 319
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1039732562 372 SAVGLTTIVECCPVLFGPPLAGKLLDITGeYKYLYIASGTVVLVSGTYLLI 422
Cdd:cd17490 320 TAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLA 369
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|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
28-187 |
7.38e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 7.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 28 FISIGFSYAFPKAV--TVFFKDIQEIFNTTSSQIAWISSIM-LAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILA 104
Cdd:cd17330 179 LLLVYFLIALAFAGleSVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732562 105 SYSNSVIELYLTVGFIgGLGLAFNLQPALTIIGKYFY-RRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILG 183
Cdd:cd17330 259 PFASSVPLLVLAAAIL-AFGTGIVFPALSALLSKSVPsKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAA 337
|
....
gi 1039732562 184 GIFL 187
Cdd:cd17330 338 GLLL 341
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