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Conserved domains on  [gi|1046859051|ref|XP_017454767|]
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slit homolog 2 protein isoform X4 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1175-1308 4.03e-31

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 119.37  E-value: 4.03e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  1175 NITLQIATDEDSGILLY---KGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGG 1251
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046859051  1252 SPKIITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYINSE 1308
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLP-----EDLKLPPLPVTPGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
556-853 4.83e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 4.83e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  556 NLSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRsnriscvGNDSFTGLGSVRLLSLYDNQIT 635
Cdd:COG4886     54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  636 TVaPGAFGTLHSLSTLNLLANPfncnchlawlgewlrrkrivtgnprcqkpyfLKEIPiqdvaiqdftcddgnddnscSP 715
Cdd:COG4886    127 DL-PEELANLTNLKELDLSNNQ-------------------------------LTDLP--------------------EP 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  716 LSRCPSectcLdTVVRCSNKGLKVLPKGIPR--DVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMT 793
Cdd:COG4886    155 LGNLTN----L-KSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLT 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  794 QLLTLILSYNRLRCIPprTFDGLKSLRLLSLHGNDISVVPEgaFGDLSALSHLAIGANPL 853
Cdd:COG4886    229 NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-211 2.49e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 2.49e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   56 NTERLDLNGNNITRITKtDFAGLRHLRVLQLMENKISTIERgAFQDLKELERLRLNRNNLQLFPELLfLGTAKLYRLDLS 135
Cdd:COG4886    114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLS 190

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046859051  136 ENQIQAIPrKAFRGAVDIKNLQLDYNQISCIEDgAFRALRDLEVLTLNNNNITRLSvaSFNHMPKLRTFRLHSNNL 211
Cdd:COG4886    191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
302-659 1.18e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 1.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  302 ITEIRLEQNSirvippgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKITELPKSLFEglfslqllllna 381
Cdd:COG4886     98 LTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN------------ 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  382 nkinclrvdafqdLHNLNLLSLYDNKLQTVAKgtfsalraiqtmHLAQNPficdcHLKWLadYLHTNPIETsgarctspr 461
Cdd:COG4886    158 -------------LTNLKSLDLSNNQLTDLPE------------ELGNLT-----NLKEL--DLSNNQITD--------- 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  462 rlANKRIGQIKskkfrcsgtedyrsKLsgdcfadlacpekcrcegTTVDCSNQKLNKIPDHIPQYTA--ELRLNNNEFTV 539
Cdd:COG4886    197 --LPEPLGNLT--------------NL------------------EELDLSGNQLTDLPEPLANLTNleTLDLSNNQLTD 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  540 LEAtgiFKKLPQLRKINLSNNKITDIEEGAfegasgvneilltsnrlenvqhkmfkGLESLKTLMLRSNRISCVGNDSFT 619
Cdd:COG4886    243 LPE---LGNLTNLEELDLSNNQLTDLPPLA--------------------------NLTNLKTLDLSNNQLTDLKLKELE 293

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1046859051  620 GLGSVRLLSLYDNQITTVAPGAFGTLHSLSTLNLLANPFN 659
Cdd:COG4886    294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 824-1005 3.82e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.02  E-value: 3.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  824 LHGNDISVVPEGAFGDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTCq 900
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  901 gpvDVTIQAkcnpCLSNPCKNDGTCNNDPVDFYRCTcPYGFKGQDCDVpihACISNPCKHGGTchlkeGENDgfWCTCAD 980
Cdd:TIGR00864   81 ---DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFSAGHGLAAL-----GEQG--ECLCGA 142

                          170       180
                   ....*....|....*....|....*
gi 1046859051  981 GFEGESCDINIDDCEDNDCENNSTC 1005
Cdd:TIGR00864  143 AQPSEANFACESLCSGPPPPPAAAC 167
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1068-1104 2.99e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 2.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046859051 1068 DFDDCQD-NKCKNGAHCTDAVNGYTCVCPEGYSGLFCE 1104
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 990-1026 3.23e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.23e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046859051  990 NIDDCED-NDCENNSTCVDGINNYTCLCPPEYTGELCE 1026
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-58 6.13e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 6.13e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1046859051    27 ACPAQCSCSGSTVDCHGLALRSVPRNIPRNTE 58
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1030-1065 1.33e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.33e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1046859051 1030 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYIGEHC 1065
Cdd:cd00054      3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 182-319 1.54e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.08  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQ------RPRVglyTQCMGPSHLRGH---------- 245
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQpllgipllds 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  246 ----------------NVAEVQKREFVCSGHQSFMAPScsvlHCPIAC-TCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308
Cdd:TIGR00864   79 gcdeeyvaclkdnssgGGAARSELVIFSAAHEGLFQPE----ACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACES 154

                          170
                   ....*....|.
gi 1046859051  309 QNSIRVIPPGA 319
Cdd:TIGR00864  155 LCSGPPPPPAA 165
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1175-1308 4.03e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 119.37  E-value: 4.03e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  1175 NITLQIATDEDSGILLY---KGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGG 1251
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046859051  1252 SPKIITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYINSE 1308
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLP-----EDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1153-1306 1.31e-27

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 109.82  E-value: 1.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051 1153 SVNFvNKESYLQIP-SAKVRPQTNITLQIATDEDSGILLYKGDK---DHIAVELYRGRVRASYDTGSHPASaIYSVETIN 1228
Cdd:cd00110      1 GVSF-SGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSQnggDFLALELEDGRLVLRYDLGSGSLV-LSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046859051 1229 DGNFHIVELLTLDSSLSLSVDGGSPKIITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYIN 1306
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP-----EDLKSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1182-1308 3.02e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 105.19  E-value: 3.02e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051 1182 TDEDSGILLYKGD--KDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGGSPKIITNL 1259
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1046859051 1260 SKQSTLNFDSPLYVGGMPGKNNVASLRQAPGqngtsFHGCIRNLYINSE 1308
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRAG-----FVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
556-853 4.83e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 4.83e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  556 NLSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRsnriscvGNDSFTGLGSVRLLSLYDNQIT 635
Cdd:COG4886     54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  636 TVaPGAFGTLHSLSTLNLLANPfncnchlawlgewlrrkrivtgnprcqkpyfLKEIPiqdvaiqdftcddgnddnscSP 715
Cdd:COG4886    127 DL-PEELANLTNLKELDLSNNQ-------------------------------LTDLP--------------------EP 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  716 LSRCPSectcLdTVVRCSNKGLKVLPKGIPR--DVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMT 793
Cdd:COG4886    155 LGNLTN----L-KSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLT 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  794 QLLTLILSYNRLRCIPprTFDGLKSLRLLSLHGNDISVVPEgaFGDLSALSHLAIGANPL 853
Cdd:COG4886    229 NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-211 2.49e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 2.49e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   56 NTERLDLNGNNITRITKtDFAGLRHLRVLQLMENKISTIERgAFQDLKELERLRLNRNNLQLFPELLfLGTAKLYRLDLS 135
Cdd:COG4886    114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLS 190

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046859051  136 ENQIQAIPrKAFRGAVDIKNLQLDYNQISCIEDgAFRALRDLEVLTLNNNNITRLSvaSFNHMPKLRTFRLHSNNL 211
Cdd:COG4886    191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
302-659 1.18e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 1.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  302 ITEIRLEQNSirvippgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKITELPKSLFEglfslqllllna 381
Cdd:COG4886     98 LTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN------------ 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  382 nkinclrvdafqdLHNLNLLSLYDNKLQTVAKgtfsalraiqtmHLAQNPficdcHLKWLadYLHTNPIETsgarctspr 461
Cdd:COG4886    158 -------------LTNLKSLDLSNNQLTDLPE------------ELGNLT-----NLKEL--DLSNNQITD--------- 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  462 rlANKRIGQIKskkfrcsgtedyrsKLsgdcfadlacpekcrcegTTVDCSNQKLNKIPDHIPQYTA--ELRLNNNEFTV 539
Cdd:COG4886    197 --LPEPLGNLT--------------NL------------------EELDLSGNQLTDLPEPLANLTNleTLDLSNNQLTD 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  540 LEAtgiFKKLPQLRKINLSNNKITDIEEGAfegasgvneilltsnrlenvqhkmfkGLESLKTLMLRSNRISCVGNDSFT 619
Cdd:COG4886    243 LPE---LGNLTNLEELDLSNNQLTDLPPLA--------------------------NLTNLKTLDLSNNQLTDLKLKELE 293

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1046859051  620 GLGSVRLLSLYDNQITTVAPGAFGTLHSLSTLNLLANPFN 659
Cdd:COG4886    294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR_8 pfam13855
Leucine rich repeat;
770-829 1.61e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 74.87  E-value: 1.61e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  770 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 829
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
55-115 9.11e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 9.11e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046859051   55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNNL 115
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
303-360 8.11e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 8.11e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046859051  303 TEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 360
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-211 6.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 6.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   60 LDLNGNNITRITktDFAGLRHLRVLQLMENKISTIErgAFQDLKELERLRLNRNNLQlfpELLFLGT-AKLYRLDLSENQ 138
Cdd:cd21340      7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE---KIENLENlVNLKKLYLGGNR 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046859051  139 IQAIprKAFRGAVDIKNLQLDYNQIS-----CIEDGAFRALRD-LEVLTLNNNNITrlSVASFNHMPKLRTFRLHSNNL 211
Cdd:cd21340     80 ISVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQI 154
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 629-705 1.10e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 67.03  E-value: 1.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  629 LYDNQITTVAPGAFGTLHSLSTLNLLANPFNCNCHLAWLGEWLRRKRIVTGNPR---CQKPYFLKEIPIQDVAIQDFTCD 705
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 746-846 4.32e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.34  E-value: 4.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  746 RDVTELYLDGNQFTLVPkELSNYKHLTLIDLSNNRISTLSNqsFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLH 825
Cdd:cd21340      2 KRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                           90       100
                   ....*....|....*....|.
gi 1046859051  826 GNDISVVpEGaFGDLSALSHL 846
Cdd:cd21340     77 GNRISVV-EG-LENLTNLEEL 95
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
515-823 9.73e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 9.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  515 KLNKIPDHIPQYTAELRLNNNEftvleatgiFKKLPQ-----LRKINLSNNKITDIEEGAfegASGVNEILLTSNRLENV 589
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNE---------LKSLPEnlqgnIKTLYANSNQLTSIPATL---PDTIQEMELSINRITEL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  590 QHKMfkgLESLKTLMLRSNRISCVGNDSFTGLgsvRLLSLYDNQITTVaPGAFGTlhSLSTLNLLANPfncnchLAWLGE 669
Cdd:PRK15370   257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  670 WLrrkrivtgnprcqkPYFLKEIPIQDVAIqdftcddgnddnSCSPLSrCPSECTCLDTvvrcSNKGLKVLPKGIPRDVT 749
Cdd:PRK15370   322 TL--------------PPGLKTLEAGENAL------------TSLPAS-LPPELQVLDV----SKNQITVLPETLPPTIT 370

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046859051  750 ELYLDGNQFTLVPKELSnyKHLTLIDLSNNRISTL--SNQSF-SNMTQLLTLILSYNRlrcIPPRTFDGLKslRLLS 823
Cdd:PRK15370   371 TLDVSRNALTNLPENLP--AALQIMQASRNNLVRLpeSLPHFrGEGPQPTRIIVEYNP---FSERTIQNMQ--RLMS 440
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 824-1005 3.82e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.02  E-value: 3.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  824 LHGNDISVVPEGAFGDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTCq 900
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  901 gpvDVTIQAkcnpCLSNPCKNDGTCNNDPVDFYRCTcPYGFKGQDCDVpihACISNPCKHGGTchlkeGENDgfWCTCAD 980
Cdd:TIGR00864   81 ---DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFSAGHGLAAL-----GEQG--ECLCGA 142

                          170       180
                   ....*....|....*....|....*
gi 1046859051  981 GFEGESCDINIDDCEDNDCENNSTC 1005
Cdd:TIGR00864  143 AQPSEANFACESLCSGPPPPPAAAC 167
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-211 2.33e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 2.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNNLqlFPELL-FLGTAKLYRLD 133
Cdd:PLN00113   404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF--FGGLPdSFGSKRLENLD 481

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046859051  134 LSENQIQ-AIPRKaFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Cdd:PLN00113   482 LSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1068-1104 2.99e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 2.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046859051 1068 DFDDCQD-NKCKNGAHCTDAVNGYTCVCPEGYSGLFCE 1104
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 990-1026 3.23e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.23e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046859051  990 NIDDCED-NDCENNSTCVDGINNYTCLCPPEYTGELCE 1026
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
287-367 1.07e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  287 RGKGLTEIPTNLPETITEIRLEQNSIRVIP---PGAfspykkLRRLDLSNNQISELAPDAFQGLRSLNslvLYGNKITEL 363
Cdd:PRK15370   228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                   ....
gi 1046859051  364 PKSL 367
Cdd:PRK15370   299 PAHL 302
LRRCT smart00082
Leucine rich repeat C-terminal domain;
851-900 4.88e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 4.88e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1046859051   851 NPLYCDCNMQWLSDWVKSE--YKEPGIARCAGPGEMADKLLLTTPSkKFTCQ 900
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-58 6.13e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 6.13e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1046859051    27 ACPAQCSCSGSTVDCHGLALRSVPRNIPRNTE 58
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1068-1104 9.49e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.49e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1046859051  1068 DFDDCQ-DNKCKNGAHCTDAVNGYTCVCPEGYS-GLFCE 1104
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
990-1026 1.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.18e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1046859051   990 NIDDCE-DNDCENNSTCVDGINNYTCLCPPEYT-GELCE 1026
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-367 1.20e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTierGAFQDL---KELERLRLNRNNLQ-LFPELLfLGTAKLY 130
Cdd:PLN00113   308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG---EIPKNLgkhNNLTVLDLSTNNLTgEIPEGL-CSSGNLF 383

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  131 RLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIT-RLSVASFNhMPKLRTFRLHSN 209
Cdd:PLN00113   384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARN 462

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  210 NLYcdchlawlsdwlrqrprvGLYTQCMGPSHLRGHNVAEVQKREFVcsgHQSFMapscsvlhcpiactcsnnivdcrgk 289
Cdd:PLN00113   463 KFF------------------GGLPDSFGSKRLENLDLSRNQFSGAV---PRKLG------------------------- 496

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046859051  290 glteiptNLPEtITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT-ELPKSL 367
Cdd:PLN00113   497 -------SLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1030-1065 1.33e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.33e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1046859051 1030 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYIGEHC 1065
Cdd:cd00054      3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 182-319 1.54e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.08  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQ------RPRVglyTQCMGPSHLRGH---------- 245
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQpllgipllds 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  246 ----------------NVAEVQKREFVCSGHQSFMAPScsvlHCPIAC-TCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308
Cdd:TIGR00864   79 gcdeeyvaclkdnssgGGAARSELVIFSAAHEGLFQPE----ACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACES 154

                          170
                   ....*....|.
gi 1046859051  309 QNSIRVIPPGA 319
Cdd:TIGR00864  155 LCSGPPPPPAA 165
LRRNT smart00013
Leucine rich repeat N-terminal domain;
719-750 2.13e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 2.13e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1046859051   719 CPSECTCLDTVVRCSNKGLKVLPKGIPRDVTE 750
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
209-258 2.72e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 2.72e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1046859051   209 NNLYCDCHLAWLSDWLRQRPRV--GLYTQCMGPSHLRGhNVAEVQKREFVCS 258
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKCP 51
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1072-1100 3.64e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.64e-05
                           10        20
                   ....*....|....*....|....*....
gi 1046859051 1072 CQDNKCKNGAHCTDAVNGYTCVCPEGYSG 1100
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 390-638 4.57e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 4.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  390 DAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHlaqnpficdcHLKwladyLHTNPIETSGAR--CTSPRRLankr 467
Cdd:cd00116     75 QGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLQ----------ELK-----LNNNGLGDRGLRllAKGLKDL---- 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  468 igQIKSKKFRCSgtedyRSKLSGDCFADLA--CPEKCRCEgtTVDCSNqklNKIPDHIPQYTAElrlnnneftvleatgI 545
Cdd:cd00116    136 --PPALEKLVLG-----RNRLEGASCEALAkaLRANRDLK--ELNLAN---NGIGDAGIRALAE---------------G 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  546 FKKLPQLRKINLSNNKITDIEEGAFEGAsgvneilltsnrlenvqhkmFKGLESLKTLMLRSNRISCVG-----NDSFTG 620
Cdd:cd00116    189 LKANCNLEVLDLNNNGLTDEGASALAET--------------------LASLKSLEVLNLGDNNLTDAGaaalaSALLSP 248

                          250
                   ....*....|....*...
gi 1046859051  621 LGSVRLLSLYDNQITTVA 638
Cdd:cd00116    249 NISLLTLSLSCNDITDDG 266
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 994-1023 1.47e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.47e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1046859051  994 CEDNDCENNSTCVDGINNYTCLCPPEYTGE 1023
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-54 1.87e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 1.87e-04
                           10        20
                   ....*....|....*....|....*...
gi 1046859051   27 ACPAQCSCSGSTVDCHGLALRSVPRNIP 54
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
325-346 3.16e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 3.16e-04
                            10        20
                    ....*....|....*....|..
gi 1046859051   325 KLRRLDLSNNQISELAPDAFQG 346
Cdd:smart00369    3 NLRELDLSNNQLSSLPPGAFQG 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1035-1064 3.19e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 3.19e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1046859051 1035 DLNPCQHDSKCILTPKGFKCDCTPGYIGEH 1064
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 403-466 3.55e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 3.55e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046859051  403 LYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET---SGARCTSPRRLANK 466
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-946 7.93e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1046859051  912 NPCLS-NPCKNDGTCNNDPVDfYRCTCPYGFKGQDC 946
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 273-299 1.03e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 1.03e-03
                           10        20
                   ....*....|....*....|....*..
gi 1046859051  273 CPIACTCSNNIVDCRGKGLTEIPTNLP 299
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
1030-1066 4.13e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.13e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1046859051  1030 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYI-GEHCD 1066
Cdd:smart00179    3 DECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 914-943 4.23e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.23e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1046859051  914 CLSNPCKNDGTCNNDPVDfYRCTCPYGFKG 943
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGG-YTCICPEGYTG 29
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1175-1308 4.03e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 119.37  E-value: 4.03e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  1175 NITLQIATDEDSGILLY---KGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGG 1251
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046859051  1252 SPKIITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYINSE 1308
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLP-----EDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1153-1306 1.31e-27

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 109.82  E-value: 1.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051 1153 SVNFvNKESYLQIP-SAKVRPQTNITLQIATDEDSGILLYKGDK---DHIAVELYRGRVRASYDTGSHPASaIYSVETIN 1228
Cdd:cd00110      1 GVSF-SGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSQnggDFLALELEDGRLVLRYDLGSGSLV-LSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046859051 1229 DGNFHIVELLTLDSSLSLSVDGGSPKIITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYIN 1306
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP-----EDLKSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1182-1308 3.02e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 105.19  E-value: 3.02e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051 1182 TDEDSGILLYKGD--KDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGGSPKIITNL 1259
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1046859051 1260 SKQSTLNFDSPLYVGGMPGKNNVASLRQAPGqngtsFHGCIRNLYINSE 1308
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRAG-----FVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
556-853 4.83e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 4.83e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  556 NLSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRsnriscvGNDSFTGLGSVRLLSLYDNQIT 635
Cdd:COG4886     54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  636 TVaPGAFGTLHSLSTLNLLANPfncnchlawlgewlrrkrivtgnprcqkpyfLKEIPiqdvaiqdftcddgnddnscSP 715
Cdd:COG4886    127 DL-PEELANLTNLKELDLSNNQ-------------------------------LTDLP--------------------EP 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  716 LSRCPSectcLdTVVRCSNKGLKVLPKGIPR--DVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMT 793
Cdd:COG4886    155 LGNLTN----L-KSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLT 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  794 QLLTLILSYNRLRCIPprTFDGLKSLRLLSLHGNDISVVPEgaFGDLSALSHLAIGANPL 853
Cdd:COG4886    229 NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQL 284
Laminin_G_1 pfam00054
Laminin G domain;
1180-1311 7.37e-24

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 98.54  E-value: 7.37e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051 1180 IATDEDSGILLYKGDKDH---IAVELYRGRVRASYDTGSHPASaIYSVETINDGNFHIVELLTLDSSLSLSVDGG-SPKI 1255
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYDLGSGAAV-VRSGDKLNDGKWHSVELERNGRSGTLSVDGEaRPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046859051 1256 ITNLSKQSTLNFDSPLYVGGMPgkNNVASLRQAPgqNGTSFHGCIRNLYINSELQD 1311
Cdd:pfam00054   80 ESPLGATTDLDVDGPLYVGGLP--SLGVKKRRLA--ISPSFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
512-830 1.59e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 1.59e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  512 SNQKLNKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGafegasgvneilltsnrlenvqh 591
Cdd:COG4886     75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEE----------------------- 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  592 kmFKGLESLKTLMLRSNRISCVGnDSFTGLGSVRLLSLYDNQITTVaPGAFGTLHSLSTLNLlanpfncnchlawlgewl 671
Cdd:COG4886    132 --LANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL------------------ 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  672 rrkrivTGNPrcqkpyfLKEIPiqdvaiqdftcddgnddnscSPLSRCPSectcldtvvrcsnkglkvlpkgiprdVTEL 751
Cdd:COG4886    190 ------SNNQ-------ITDLP--------------------EPLGNLTN--------------------------LEEL 210

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046859051  752 YLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSnqSFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLHGNDIS 830
Cdd:COG4886    211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-211 2.49e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 2.49e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   56 NTERLDLNGNNITRITKtDFAGLRHLRVLQLMENKISTIERgAFQDLKELERLRLNRNNLQLFPELLfLGTAKLYRLDLS 135
Cdd:COG4886    114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLS 190

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046859051  136 ENQIQAIPrKAFRGAVDIKNLQLDYNQISCIEDgAFRALRDLEVLTLNNNNITRLSvaSFNHMPKLRTFRLHSNNL 211
Cdd:COG4886    191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-448 3.26e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.26e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   52 NIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKistiergAFQDLKELERLRLNRNNLQLFPELLFLGTaKLYR 131
Cdd:COG4886     69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLT-NLKE 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  132 LDLSENQIQAIPrKAFRGAVDIKNLQLDYNQISCIeDGAFRALRDLEVLTLNNNNITRLSvASFNHMPKLRTFRLHSNNl 211
Cdd:COG4886    141 LDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ- 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  212 ycdchlawlsdwlrqrprvglytqcmgpshlrghnvaevqkrefvcsghqsfmapscsvlhcpiactcsnnivdcrgkgL 291
Cdd:COG4886    217 -------------------------------------------------------------------------------L 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  292 TEIPTNLPE--TITEIRLEQNSIRVIPpgAFSPYKKLRRLDLSNNQISELAPDAfqGLRSLNSLVLYGNKITELP-KSLF 368
Cdd:COG4886    218 TDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELE 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  369 EGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTN 448
Cdd:COG4886    294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
507-658 2.36e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 2.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  507 TTVDCSNQKLNKIPDHIPQYTA--ELRLNNNEFTVLEATgiFKKLPQLRKINLSNNKITDIEEgAFEGASGVNEILLTSN 584
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANLTNlkELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046859051  585 RLENVqHKMFKGLESLKTLMLRSNRISCVGnDSFTGLGSVRLLSLYDNQITTVApgAFGTLHSLSTLNLLANPF 658
Cdd:COG4886    193 QITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-195 2.51e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 2.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   38 TVDCHGLALRSVPRNIPRNT--ERLDLNGNNITRITKtDFAGLRHLRVLQLMENKISTIErGAFQDLKELERLRLNRNNL 115
Cdd:COG4886    140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQL 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  116 QLFPELLFlGTAKLYRLDLSENQIQAIPrkAFRGAVDIKNLQLDYNQISCIEDGAfrALRDLEVLTLNNNNITRLSVASF 195
Cdd:COG4886    218 TDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
302-659 1.18e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 1.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  302 ITEIRLEQNSirvippgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKITELPKSLFEglfslqllllna 381
Cdd:COG4886     98 LTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN------------ 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  382 nkinclrvdafqdLHNLNLLSLYDNKLQTVAKgtfsalraiqtmHLAQNPficdcHLKWLadYLHTNPIETsgarctspr 461
Cdd:COG4886    158 -------------LTNLKSLDLSNNQLTDLPE------------ELGNLT-----NLKEL--DLSNNQITD--------- 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  462 rlANKRIGQIKskkfrcsgtedyrsKLsgdcfadlacpekcrcegTTVDCSNQKLNKIPDHIPQYTA--ELRLNNNEFTV 539
Cdd:COG4886    197 --LPEPLGNLT--------------NL------------------EELDLSGNQLTDLPEPLANLTNleTLDLSNNQLTD 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  540 LEAtgiFKKLPQLRKINLSNNKITDIEEGAfegasgvneilltsnrlenvqhkmfkGLESLKTLMLRSNRISCVGNDSFT 619
Cdd:COG4886    243 LPE---LGNLTNLEELDLSNNQLTDLPPLA--------------------------NLTNLKTLDLSNNQLTDLKLKELE 293

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1046859051  620 GLGSVRLLSLYDNQITTVAPGAFGTLHSLSTLNLLANPFN 659
Cdd:COG4886    294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
283-452 2.31e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 2.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  283 IVDCRGKGLTEIPTNLPE--TITEIRLEQNSIRVIPPgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKI 360
Cdd:COG4886    140 ELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  361 TELPKSLfeglfslqllllnankinclrvdafQDLHNLNLLSLYDNKLQTVAKgtFSALRAIQTMHLAQN-----PFICD 435
Cdd:COG4886    218 TDLPEPL-------------------------ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNqltdlPPLAN 270

                          170
                   ....*....|....*...
gi 1046859051  436 CH-LKWLadYLHTNPIET 452
Cdd:COG4886    271 LTnLKTL--DLSNNQLTD 286
LRR_8 pfam13855
Leucine rich repeat;
770-829 1.61e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 74.87  E-value: 1.61e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  770 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 829
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
302-672 1.73e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.83  E-value: 1.73e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  302 ITEIRLEQNSIRVIPPgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKITELPKSLfeglfslqllllna 381
Cdd:COG4886    115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEEL-------------- 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  382 nkinclrvdafQDLHNLNLLSLYDNKLQTVAKgTFSALRAIQTMHLAQNPFicdchlkwladylhtNPIETSGARCTspr 461
Cdd:COG4886    179 -----------GNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL---------------TDLPEPLANLT--- 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  462 rlankrigqikskkfrcsgtedyrsKLsgdcfadlacpekcrcegTTVDCSNQKLNKIPD--HIPQYTaELRLNNNEFTV 539
Cdd:COG4886    229 -------------------------NL------------------ETLDLSNNQLTDLPElgNLTNLE-ELDLSNNQLTD 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  540 LEATGifkKLPQLRKINLSNNKITDIEEGAFEGASGVNeiLLTSNRLENVQHKMFKGLESLKTLMLRSNRISCVGNDSFT 619
Cdd:COG4886    265 LPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLN--SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1046859051  620 GLGSVRLLSLYDNQITTVAPGAFGTLHSLSTLNLLANPFNCNCHLAWLGEWLR 672
Cdd:COG4886    340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-192 7.12e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 7.12e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   38 TVDCHGLALRSVPRNIPR--NTERLDLNGNNITRITKTdFAGLRHLRVLQLMENKISTIERgAFQDLKELERLRLNRNNL 115
Cdd:COG4886    163 SLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046859051  116 QLFPELLFLgtAKLYRLDLSENQIQAIPrkAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSV 192
Cdd:COG4886    241 TDLPELGNL--TNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR_8 pfam13855
Leucine rich repeat;
55-115 9.11e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 9.11e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046859051   55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNNL 115
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
303-360 8.11e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 8.11e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046859051  303 TEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 360
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
574-634 8.63e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 8.63e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046859051  574 SGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRISCVGNDSFTGLGSVRLLSLYDNQI 634
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
154-211 1.09e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 1.09e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046859051  154 KNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
599-658 3.23e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 3.23e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  599 SLKTLMLRSNRISCVGNDSFTGLGSVRLLSLYDNQITTVAPGAFGTLHSLSTLNLLANPF 658
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-211 6.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 6.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   60 LDLNGNNITRITktDFAGLRHLRVLQLMENKISTIErgAFQDLKELERLRLNRNNLQlfpELLFLGT-AKLYRLDLSENQ 138
Cdd:cd21340      7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE---KIENLENlVNLKKLYLGGNR 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046859051  139 IQAIprKAFRGAVDIKNLQLDYNQIS-----CIEDGAFRALRD-LEVLTLNNNNITrlSVASFNHMPKLRTFRLHSNNL 211
Cdd:cd21340     80 ISVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-209 6.97e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 6.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   55 RNTERLDLNGNNITRItkTDFAGLRHLRVLQLMENKISTIErgAFQDLKELERLRLNRNNLQLFPELLF-----LGTAK- 128
Cdd:cd21340     46 TNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFdprslAALSNs 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  129 LYRLDLSENQIQaiprkafrgavDIKNLQldynqisciedgafrALRDLEVLTLNNNNITRLSVAS--FNHMPKLRTFRL 206
Cdd:cd21340    122 LRVLNISGNNID-----------SLEPLA---------------PLRNLEQLDASNNQISDLEELLdlLSSWPSLRELDL 175


                   ...
gi 1046859051  207 HSN 209
Cdd:cd21340    176 TGN 178
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 629-705 1.10e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 67.03  E-value: 1.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  629 LYDNQITTVAPGAFGTLHSLSTLNLLANPFNCNCHLAWLGEWLRRKRIVTGNPR---CQKPYFLKEIPIQDVAIQDFTCD 705
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81
LRR_8 pfam13855
Leucine rich repeat;
128-187 1.18e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 1.18e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  128 KLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNI 187
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
793-853 2.15e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 2.15e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046859051  793 TQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFGDLSALSHLAIGANPL 853
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
748-805 3.37e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 3.37e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1046859051  748 VTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRL 805
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 746-846 4.32e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.34  E-value: 4.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  746 RDVTELYLDGNQFTLVPkELSNYKHLTLIDLSNNRISTLSNqsFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLH 825
Cdd:cd21340      2 KRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                           90       100
                   ....*....|....*....|.
gi 1046859051  826 GNDISVVpEGaFGDLSALSHL 846
Cdd:cd21340     77 GNRISVV-EG-LENLTNLEEL 95
LRR_8 pfam13855
Leucine rich repeat;
529-586 7.37e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 7.37e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046859051  529 ELRLNNNEFTVLEAtGIFKKLPQLRKINLSNNKITDIEEGAFEGASGVNEILLTSNRL 586
Cdd:pfam13855    5 SLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
515-823 9.73e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 9.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  515 KLNKIPDHIPQYTAELRLNNNEftvleatgiFKKLPQ-----LRKINLSNNKITDIEEGAfegASGVNEILLTSNRLENV 589
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNE---------LKSLPEnlqgnIKTLYANSNQLTSIPATL---PDTIQEMELSINRITEL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  590 QHKMfkgLESLKTLMLRSNRISCVGNDSFTGLgsvRLLSLYDNQITTVaPGAFGTlhSLSTLNLLANPfncnchLAWLGE 669
Cdd:PRK15370   257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  670 WLrrkrivtgnprcqkPYFLKEIPIQDVAIqdftcddgnddnSCSPLSrCPSECTCLDTvvrcSNKGLKVLPKGIPRDVT 749
Cdd:PRK15370   322 TL--------------PPGLKTLEAGENAL------------TSLPAS-LPPELQVLDV----SKNQITVLPETLPPTIT 370

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046859051  750 ELYLDGNQFTLVPKELSnyKHLTLIDLSNNRISTL--SNQSF-SNMTQLLTLILSYNRlrcIPPRTFDGLKslRLLS 823
Cdd:PRK15370   371 TLDVSRNALTNLPENLP--AALQIMQASRNNLVRLpeSLPHFrGEGPQPTRIIVEYNP---FSERTIQNMQ--RLMS 440
LRR_8 pfam13855
Leucine rich repeat;
79-139 1.61e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.61e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046859051   79 RHLRVLQLMENKISTIERGAFQDLKELERLRLNRNNLQLFPELLFLGTAKLYRLDLSENQI 139
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
325-408 1.74e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  325 KLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKslfeglfslqllllnankinclrvDAFQDLHNLNLLSLY 404
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP------------------------GAFSGLPSLRYLDLS 57


                   ....
gi 1046859051  405 DNKL 408
Cdd:pfam13855   58 GNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 824-1005 3.82e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.02  E-value: 3.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  824 LHGNDISVVPEGAFGDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTCq 900
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  901 gpvDVTIQAkcnpCLSNPCKNDGTCNNDPVDFYRCTcPYGFKGQDCDVpihACISNPCKHGGTchlkeGENDgfWCTCAD 980
Cdd:TIGR00864   81 ---DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFSAGHGLAAL-----GEQG--ECLCGA 142

                          170       180
                   ....*....|....*....|....*
gi 1046859051  981 GFEGESCDINIDDCEDNDCENNSTC 1005
Cdd:TIGR00864  143 AQPSEANFACESLCSGPPPPPAAAC 167
PLN03150 PLN03150
hypothetical protein; Provisional
 761-854 9.60e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.83  E-value: 9.60e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  761 VPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISvvpegafGDL 840
Cdd:PLN03150   434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS-------GRV 506

                           90
                   ....*....|....
gi 1046859051  841 SAlshlAIGANPLY 854
Cdd:PLN03150   507 PA----ALGGRLLH 516
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-211 2.33e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 2.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNNLqlFPELL-FLGTAKLYRLD 133
Cdd:PLN00113   404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF--FGGLPdSFGSKRLENLD 481

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046859051  134 LSENQIQ-AIPRKaFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Cdd:PLN00113   482 LSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
725-853 3.77e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 3.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  725 CL---DTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKEL-SNYKHLT------------------LIDLSNNRIS 782
Cdd:PRK15370   175 CLknnKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLqGNIKTLYansnqltsipatlpdtiqEMELSINRIT 254

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046859051  783 TLSNQSFSnmtQLLTLILSYNRLRCIPPRTFDGlksLRLLSLHGNDISVVPEGAfgdLSALSHLAIGANPL 853
Cdd:PRK15370   255 ELPERLPS---ALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSL 316
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 322-855 1.08e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  322 PYkkLRRLDLSNNQISELAPDA-FQGLRSLNSLVLYGNKITelpKSLFEGLFSLQLLLLNANkiNCLRVDAFQDL---HN 397
Cdd:PLN00113    93 PY--IQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFT---GSIPRGSIPNLETLDLSN--NMLSGEIPNDIgsfSS 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  398 LNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDC--------HLKWLadYLHTN------PIETSGarCTSPRRL 463
Cdd:PLN00113   166 LKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIprelgqmkSLKWI--YLGYNnlsgeiPYEIGG--LTSLNHL 241

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  464 A---NKRIGQIKSKKFRCSGTED---YRSKLSGDCFADLACPEKCrcegTTVDCSNQKLN-KIPDHIPQY-TAE-LRLNN 534
Cdd:PLN00113   242 DlvyNNLTGPIPSSLGNLKNLQYlflYQNKLSGPIPPSIFSLQKL----ISLDLSDNSLSgEIPELVIQLqNLEiLHLFS 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  535 NEFTVLEATGIfKKLPQLRKINLSNNKIT----------------DIEEGAFEG-------ASG-VNEILLTSNRLENVQ 590
Cdd:PLN00113   318 NNFTGKIPVAL-TSLPRLQVLQLWSNKFSgeipknlgkhnnltvlDLSTNNLTGeipeglcSSGnLFKLILFSNSLEGEI 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  591 HKMFKGLESLKTLMLRSNRISCVGNDSFTGLGSVRLLSLYDNQITTVAPGAFGTLHSLSTLNLLANPFNCNchlawLGEW 670
Cdd:PLN00113   397 PKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG-----LPDS 471

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  671 LRRKRIvtgnprcqkpyflkeipiqdvaiqdftcddGNDDnscspLSRcpsectcldtvvrcsNKGLKVLPKGIPR--DV 748
Cdd:PLN00113   472 FGSKRL------------------------------ENLD-----LSR---------------NQFSGAVPRKLGSlsEL 501

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  749 TELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGN 827
Cdd:PLN00113   502 MQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581

                          570       580       590
                   ....*....|....*....|....*....|
gi 1046859051  828 DI--SVVPEGAFgdlSALSHLAIGANPLYC 855
Cdd:PLN00113   582 HLhgSLPSTGAF---LAINASAVAGNIDLC 608
LRR_8 pfam13855
Leucine rich repeat;
380-432 2.47e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 2.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1046859051  380 NANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPF 432
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1068-1104 2.99e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 2.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046859051 1068 DFDDCQD-NKCKNGAHCTDAVNGYTCVCPEGYSGLFCE 1104
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 990-1026 3.23e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.23e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046859051  990 NIDDCED-NDCENNSTCVDGINNYTCLCPPEYTGELCE 1026
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
287-367 1.07e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  287 RGKGLTEIPTNLPETITEIRLEQNSIRVIP---PGAfspykkLRRLDLSNNQISELAPDAFQGLRSLNslvLYGNKITEL 363
Cdd:PRK15370   228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                   ....
gi 1046859051  364 PKSL 367
Cdd:PRK15370   299 PAHL 302
LRRCT smart00082
Leucine rich repeat C-terminal domain;
851-900 4.88e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 4.88e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1046859051   851 NPLYCDCNMQWLSDWVKSE--YKEPGIARCAGPGEMADKLLLTTPSkKFTCQ 900
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-58 6.13e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 6.13e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1046859051    27 ACPAQCSCSGSTVDCHGLALRSVPRNIPRNTE 58
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
290-411 6.90e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 6.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  290 GLTEIPTNLPETITEIRLEQNSIRVIPPGAfspYKKLRRLDLSNNQISELA---PDAFQGLRslnslvLYGNKITELPKS 366
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPatlPDTIQEME------LSINRITELPER 259

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1046859051  367 LfegLFSLQLLLLNANKINCLRvDAFQDlhNLNLLSLYDNKLQTV 411
Cdd:PRK15370   260 L---PSALQSLDLFHNKISCLP-ENLPE--ELRYLSVYDNSIRTL 298
EGF_CA smart00179
Calcium-binding EGF-like domain;
1068-1104 9.49e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.49e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1046859051  1068 DFDDCQ-DNKCKNGAHCTDAVNGYTCVCPEGYS-GLFCE 1104
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 43-214 9.66e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 9.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   43 GLALRSVPRNIPRNT--ERLDLNGNNITRITKTDFAGLRH---LRVLQLMENKIS-TIER---GAFQDLKE-LERLRLNR 112
Cdd:cd00116     67 PRGLQSLLQGLTKGCglQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGdRGLRllaKGLKDLPPaLEKLVLGR 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  113 NNL------QLFPELLFLGtaKLYRLDLSENQI--QAIPR--KAFRGAVDIKNLQLDYNQISCIED----GAFRALRDLE 178
Cdd:cd00116    147 NRLegasceALAKALRANR--DLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLE 224

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1046859051  179 VLTLNNNNIT-----RLSVASFNHMPKLRTFRLHSNNLYCD 214
Cdd:cd00116    225 VLNLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDD 265
EGF_CA smart00179
Calcium-binding EGF-like domain;
990-1026 1.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.18e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1046859051   990 NIDDCE-DNDCENNSTCVDGINNYTCLCPPEYT-GELCE 1026
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-367 1.20e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTierGAFQDL---KELERLRLNRNNLQ-LFPELLfLGTAKLY 130
Cdd:PLN00113   308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG---EIPKNLgkhNNLTVLDLSTNNLTgEIPEGL-CSSGNLF 383

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  131 RLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIT-RLSVASFNhMPKLRTFRLHSN 209
Cdd:PLN00113   384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARN 462

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  210 NLYcdchlawlsdwlrqrprvGLYTQCMGPSHLRGHNVAEVQKREFVcsgHQSFMapscsvlhcpiactcsnnivdcrgk 289
Cdd:PLN00113   463 KFF------------------GGLPDSFGSKRLENLDLSRNQFSGAV---PRKLG------------------------- 496

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046859051  290 glteiptNLPEtITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT-ELPKSL 367
Cdd:PLN00113   497 -------SLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1030-1065 1.33e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.33e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1046859051 1030 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYIGEHC 1065
Cdd:cd00054      3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 182-319 1.54e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.08  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQ------RPRVglyTQCMGPSHLRGH---------- 245
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQpllgipllds 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  246 ----------------NVAEVQKREFVCSGHQSFMAPScsvlHCPIAC-TCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308
Cdd:TIGR00864   79 gcdeeyvaclkdnssgGGAARSELVIFSAAHEGLFQPE----ACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACES 154

                          170
                   ....*....|.
gi 1046859051  309 QNSIRVIPPGA 319
Cdd:TIGR00864  155 LCSGPPPPPAA 165
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 280-449 1.73e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 1.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  280 SNNIVDCRGKGLTEIPTnLPETITEIRLEQNSIRviPPGA------FSPYKKLRRLDLSNNQIS-----ELApDAFQGLR 348
Cdd:COG5238    189 CNQIGDEGIEELAEALT-QNTTVTTLWLKRNPIG--DEGAeilaeaLKGNKSLTTLDLSNNQIGdegviALA-EALKNNT 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  349 SLNSLVLYGNKITE-----LPKSLfEGLFSLQLLLLNANKINCLRVDAFQDL----HNLNLLSLYDNKLQTV-AKGTFSA 418
Cdd:COG5238    265 TVETLYLSGNQIGAegaiaLAKAL-QGNTTLTSLDLSVNRIGDEGAIALAEGlqgnKTLHTLNLAYNGIGAQgAIALAKA 343

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1046859051  419 L---RAIQTMHLAQNPfICDCHLKWLADYLHTNP 449
Cdd:COG5238    344 LqenTTLHSLDLSDNQ-IGDEGAIALAKYLEGNT 376
LRRNT smart00013
Leucine rich repeat N-terminal domain;
719-750 2.13e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 2.13e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1046859051   719 CPSECTCLDTVVRCSNKGLKVLPKGIPRDVTE 750
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-190 2.62e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 2.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   46 LRSVPRNIPRNTERLDLNGNNITRITKT--DfaglrHLRVLQLMENKISTI-ER--GAFQDL---------------KEL 105
Cdd:PRK15370   211 LKSLPENLQGNIKTLYANSNQLTSIPATlpD-----TIQEMELSINRITELpERlpSALQSLdlfhnkisclpenlpEEL 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  106 ERLRLNRNNLQLFPELLflgTAKLYRLDLSENQIQAIPRKAfrgAVDIKNLQLDYNQISCIEDGAFRALRDLEVltlNNN 185
Cdd:PRK15370   286 RYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPELQVLDV---SKN 356


                   ....*
gi 1046859051  186 NITRL 190
Cdd:PRK15370   357 QITVL 361
LRRCT smart00082
Leucine rich repeat C-terminal domain;
209-258 2.72e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 2.72e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1046859051   209 NNLYCDCHLAWLSDWLRQRPRV--GLYTQCMGPSHLRGhNVAEVQKREFVCS 258
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKCP 51
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1072-1100 3.64e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.64e-05
                           10        20
                   ....*....|....*....|....*....
gi 1046859051 1072 CQDNKCKNGAHCTDAVNGYTCVCPEGYSG 1100
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 390-638 4.57e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 4.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  390 DAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHlaqnpficdcHLKwladyLHTNPIETSGAR--CTSPRRLankr 467
Cdd:cd00116     75 QGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLQ----------ELK-----LNNNGLGDRGLRllAKGLKDL---- 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  468 igQIKSKKFRCSgtedyRSKLSGDCFADLA--CPEKCRCEgtTVDCSNqklNKIPDHIPQYTAElrlnnneftvleatgI 545
Cdd:cd00116    136 --PPALEKLVLG-----RNRLEGASCEALAkaLRANRDLK--ELNLAN---NGIGDAGIRALAE---------------G 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  546 FKKLPQLRKINLSNNKITDIEEGAFEGAsgvneilltsnrlenvqhkmFKGLESLKTLMLRSNRISCVG-----NDSFTG 620
Cdd:cd00116    189 LKANCNLEVLDLNNNGLTDEGASALAET--------------------LASLKSLEVLNLGDNNLTDAGaaalaSALLSP 248

                          250
                   ....*....|....*...
gi 1046859051  621 LGSVRLLSLYDNQITTVA 638
Cdd:cd00116    249 NISLLTLSLSCNDITDDG 266
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 512-657 4.88e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 4.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  512 SNQKLNKIPDHIPQYTA--ELRLNNNEFTVLEATGIFKKL---PQLRKINLSNNKITDieegafEGASGVNEILLTSNRL 586
Cdd:COG5238    193 GDEGIEELAEALTQNTTvtTLWLKRNPIGDEGAEILAEALkgnKSLTTLDLSNNQIGD------EGVIALAEALKNNTTV 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  587 E-------NVQH-------KMFKGLESLKTLMLRSNRIscvGNDSFTGLG-------SVRLLSLYDNQITTVapGAFG-- 643
Cdd:COG5238    267 EtlylsgnQIGAegaialaKALQGNTTLTSLDLSVNRI---GDEGAIALAeglqgnkTLHTLNLAYNGIGAQ--GAIAla 341

                          170
                   ....*....|....*...
gi 1046859051  644 ----TLHSLSTLNLLANP 657
Cdd:COG5238    342 kalqENTTLHSLDLSDNQ 359
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 515-658 5.87e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 5.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  515 KLNKIP--DHIPQYTaELRLNNNEFTVLEAtgiFKKLPQLRKINLSNNKITDIEegAFEGASGVNEILLTSNRLENVQHK 592
Cdd:cd21340     35 KITKIEnlEFLTNLT-HLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKL 108

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046859051  593 MF-----KGL-ESLKTLMLRSNRISCVgnDSFTGLGSVRLLSLYDNQITTVAP--GAFGTLHSLSTLNLLANPF 658
Cdd:cd21340    109 TFdprslAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
LRRCT smart00082
Leucine rich repeat C-terminal domain;
656-705 6.40e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 6.40e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1046859051   656 NPFNCNCHLAWLGEWLRRKRIV--TGNPRCQKPYFLKEiPIQDVAIQDFTCD 705
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKCP 51
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 994-1023 1.47e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.47e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1046859051  994 CEDNDCENNSTCVDGINNYTCLCPPEYTGE 1023
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
LRR_8 pfam13855
Leucine rich repeat;
177-211 1.58e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.58e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1046859051  177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL 37
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-54 1.87e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 1.87e-04
                           10        20
                   ....*....|....*....|....*...
gi 1046859051   27 ACPAQCSCSGSTVDCHGLALRSVPRNIP 54
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
272-304 1.96e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.99  E-value: 1.96e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1046859051   272 HCPIACTCSNNIVDCRGKGLTEIPTNLPETITE 304
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 749-830 2.39e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  749 TELYLD------GNQFTLVP---KELSNykHLTLIDLSNNRISTLSnqSFSNMTQLLTLILSYNRLRCIPP--RTFDGLK 817
Cdd:cd21340     93 EELHIEnqrlppGEKLTFDPrslAALSN--SLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                           90
                   ....*....|...
gi 1046859051  818 SLRLLSLHGNDIS 830
Cdd:cd21340    169 SLRELDLTGNPVC 181
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 35-190 2.42e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 2.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   35 SGSTVDCHGL-ALRSVPRNiPRNTERLDLNGNNIT-----RITKTdFAGLRHLRVLQLMENKIStiERGA------FQDL 102
Cdd:COG5238    244 SNNQIGDEGViALAEALKN-NTTVETLYLSGNQIGaegaiALAKA-LQGNTTLTSLDLSVNRIG--DEGAialaegLQGN 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  103 KELERLRLNRNNLQLfPELLFLGTA-----KLYRLDLSENQIQAIPRKAF----RGAVDIKNLQLDYNQISciEDGAfRA 173
Cdd:COG5238    320 KTLHTLNLAYNGIGA-QGAIALAKAlqentTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIG--KQGA-EA 395

                          170
                   ....*....|....*..
gi 1046859051  174 LRDLevltLNNNNITRL 190
Cdd:COG5238    396 LIDA----LQTNRLHTL 408
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 719-745 2.83e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.53  E-value: 2.83e-04
                           10        20
                   ....*....|....*....|....*..
gi 1046859051  719 CPSECTCLDTVVRCSNKGLKVLPKGIP 745
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
325-346 3.16e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 3.16e-04
                            10        20
                    ....*....|....*....|..
gi 1046859051   325 KLRRLDLSNNQISELAPDAFQG 346
Cdd:smart00369    3 NLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
325-346 3.16e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 3.16e-04
                            10        20
                    ....*....|....*....|..
gi 1046859051   325 KLRRLDLSNNQISELAPDAFQG 346
Cdd:smart00370    3 NLRELDLSNNQLSSLPPGAFQG 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1035-1064 3.19e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 3.19e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1046859051 1035 DLNPCQHDSKCILTPKGFKCDCTPGYIGEH 1064
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 324-364 3.32e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 3.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1046859051  324 KKLRRLDLSNNQISELapDAFQGLRSLNSLVLYGN-KITELP 364
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLS 40
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 403-466 3.55e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 3.55e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046859051  403 LYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET---SGARCTSPRRLANK 466
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-408 3.57e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   49 VPRNIP--RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNNLQ-LFPELLFlG 125
Cdd:PLN00113   204 IPRELGqmKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-S 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  126 TAKLYRLDLSENQIQA-IPRKAfrgaVDIKNLQ---LDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL 201
Cdd:PLN00113   283 LQKLISLDLSDNSLSGeIPELV----IQLQNLEilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  202 RTFRLHSNNL-------YCDC----HLAWLSDWLR-QRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPScs 269
Cdd:PLN00113   359 TVLDLSTNNLtgeipegLCSSgnlfKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDIS-- 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  270 vlhcpiactcSNNIVDCRGKGLTEIPTnlpetITEIRLEQNSIRVIPPGAFSPyKKLRRLDLSNNQISELAPDAFQGLRS 349
Cdd:PLN00113   437 ----------NNNLQGRINSRKWDMPS-----LQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSE 500

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  350 LNSLVLYGNKIT-ELPKSLfEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKL 408
Cdd:PLN00113   501 LMQLKLSENKLSgEIPDEL-SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1077-1098 3.92e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.85  E-value: 3.92e-04
                           10        20
                   ....*....|....*....|..
gi 1046859051 1077 CKNGAHCTDAVNGYTCVCPEGY 1098
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
LRRNT smart00013
Leucine rich repeat N-terminal domain;
497-527 5.77e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.84  E-value: 5.77e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1046859051   497 ACPEKCRCEGTTVDCSNQKLNKIPDHIPQYT 527
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 177-211 6.49e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 6.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1046859051  177 LEVLTLNNNNITRLSvaSFNHMPKLRTFRLHSNNL 211
Cdd:pfam12799    3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-946 7.93e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1046859051  912 NPCLS-NPCKNDGTCNNDPVDfYRCTCPYGFKGQDC 946
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 273-299 1.03e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 1.03e-03
                           10        20
                   ....*....|....*....|....*..
gi 1046859051  273 CPIACTCSNNIVDCRGKGLTEIPTNLP 299
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1073-1100 1.04e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*...
gi 1046859051 1073 QDNKCKNGAHCTDAVNGYTCVCPEGYSG 1100
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
LRRCT smart00082
Leucine rich repeat C-terminal domain;
430-460 1.12e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 1.12e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1046859051   430 NPFICDCHLKWLADYLHTNPI--ETSGARCTSP 460
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 529-567 1.22e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 1.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046859051  529 ELRLNNNEFTVLEAtgiFKKLPQLRKINLS-NNKITDIEE 567
Cdd:pfam12799    5 VLDLSNNQITDIPP---LAKLPNLETLDLSgNNKITDLSD 41
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 58-164 1.81e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051   58 ERLDLNGNNIT----RITKTDFAGLRHLRVLQLMENKISTIE----RGAFQDLKELERLRLNRNNLQLFP-----ELLFL 124
Cdd:cd00116    168 KELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGaaalaSALLS 247

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1046859051  125 GTAKLYRLDLSENQIQAIPRKAFRGA----VDIKNLQLDYNQIS 164
Cdd:cd00116    248 PNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFG 291
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
549-572 2.53e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 2.53e-03
                            10        20
                    ....*....|....*....|....
gi 1046859051   549 LPQLRKINLSNNKITDIEEGAFEG 572
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
549-572 2.53e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 2.53e-03
                            10        20
                    ....*....|....*....|....
gi 1046859051   549 LPQLRKINLSNNKITDIEEGAFEG 572
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 995-1026 3.02e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.02e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1046859051  995 EDNDCENNSTCVDGINNYTCLCPPEYTGEL-CE 1026
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
LRR_9 pfam14580
Leucine-rich repeat;
524-636 3.46e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.13  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  524 PQYT-----AELRLNNNEFTVLEATGifKKLPQLRKINLSNNKITDIEegAFEGASGVNEILLTSNRLENVQHKMFKGLE 598
Cdd:pfam14580   13 AQYTnpvreRELDLRGYKIPIIENLG--ATLDQFDTIDFSDNEIRKLD--GFPLLRRLKTLLLNNNRICRIGEGLGEALP 88

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1046859051  599 SLKTLMLRSNRISCVGN-DSFTGLGSVRLLSLYDNQITT 636
Cdd:pfam14580   89 NLTELILTNNNLQELGDlDPLASLKKLTFLSLLRNPVTN 127
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1037-1064 3.67e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.67e-03
                           10        20
                   ....*....|....*....|....*...
gi 1046859051 1037 NPCQHDSKCILTPKGFKCDCTPGYIGEH 1064
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
279-364 3.81e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 3.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  279 CSNN---IVDCRGKGLTEIPTNLPETITEIRLEQNSIRVIPpgAFSPykKLRRLDLSNNQISELaPDAFQGLRSLNslvL 355
Cdd:PRK15387   198 CLNNgnaVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLP--ALPP--ELRTLEVSGNQLTSL-PVLPPGLLELS---I 269


                   ....*....
gi 1046859051  356 YGNKITELP 364
Cdd:PRK15387   270 FSNPLTHLP 278
EGF_CA smart00179
Calcium-binding EGF-like domain;
1030-1066 4.13e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.13e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1046859051  1030 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYI-GEHCD 1066
Cdd:smart00179    3 DECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 914-943 4.23e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.23e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1046859051  914 CLSNPCKNDGTCNNDPVDfYRCTCPYGFKG 943
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGG-YTCICPEGYTG 29
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 302-432 4.42e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 4.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046859051  302 ITEIRLEQNSIRVIPPgaFSPYKKLRRLDLSNNQISELApdafqGLRSLNSLV-LY--------GNKITELPKSLFEglf 372
Cdd:cd21340     48 LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEeLHienqrlppGEKLTFDPRSLAA--- 117

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046859051  373 slqllllnankI-NCLRV-----------DAFQDLHNLNLLSLYDNKLQ--TVAKGTFSALRAIQTMHLAQNPF 432
Cdd:cd21340    118 -----------LsNSLRVlnisgnnidslEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGNPV 180
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 999-1020 4.47e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|..
gi 1046859051  999 CENNSTCVDGINNYTCLCPPEY 1020
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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