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Conserved domains on  [gi|1370484478|ref|XP_024309378|]
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solute carrier family 41 member 3 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 283-420 2.73e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 83.26  E-value: 2.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484478 283 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 362
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370484478 363 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLG 420
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLG 117
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 144-204 1.18e-07

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 50.13  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370484478 144 KVELLCASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 204
Cdd:pfam01769  67 LLGLVVGLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 283-420 2.73e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 83.26  E-value: 2.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484478 283 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 362
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370484478 363 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLG 420
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLG 117
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
242-420 6.36e-11

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 61.42  E-value: 6.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484478 242 IVKILKFGWFPIILAMVISSFGGLIL-SKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMwsapGVLPlqmKK 320
Cdd:COG1824     7 VRRIVRESLPVLLVLAVGGIIAGLVLeGMEELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484478 321 FWPNP--CSTFCTSEINSMSARVLLLLVVpghliffYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTW 398
Cdd:COG1824    80 LRPDRrlLNNILATLILALLISPLIGVLA-------WLVAVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASY 152

                         170       180
                  ....*....|....*....|..
gi 1370484478 399 HQALDPDNHCIPYLTGLGDLLG 420
Cdd:COG1824   153 RFGLDPDNVVIPVVTTLGDVFG 174
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 144-204 1.18e-07

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 50.13  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370484478 144 KVELLCASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 204
Cdd:pfam01769  67 LLGLVVGLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
152-208 3.59e-04

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 41.39  E-value: 3.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370484478 152 SVLTAFLAAFALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFF 208
Cdd:COG1824   129 ALLAGLLLALLLIVVTYYVAIASYRFGLDPDNVVIPVVTTLGDVFGVLFLILVARLV 185
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 283-420 2.73e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 83.26  E-value: 2.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484478 283 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 362
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370484478 363 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLG 420
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLG 117
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
242-420 6.36e-11

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 61.42  E-value: 6.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484478 242 IVKILKFGWFPIILAMVISSFGGLIL-SKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMwsapGVLPlqmKK 320
Cdd:COG1824     7 VRRIVRESLPVLLVLAVGGIIAGLVLeGMEELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484478 321 FWPNP--CSTFCTSEINSMSARVLLLLVVpghliffYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTW 398
Cdd:COG1824    80 LRPDRrlLNNILATLILALLISPLIGVLA-------WLVAVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASY 152

                         170       180
                  ....*....|....*....|..
gi 1370484478 399 HQALDPDNHCIPYLTGLGDLLG 420
Cdd:COG1824   153 RFGLDPDNVVIPVVTTLGDVFG 174
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 144-204 1.18e-07

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 50.13  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370484478 144 KVELLCASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 204
Cdd:pfam01769  67 LLGLVVGLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
152-208 3.59e-04

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 41.39  E-value: 3.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370484478 152 SVLTAFLAAFALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFF 208
Cdd:COG1824   129 ALLAGLLLALLLIVVTYYVAIASYRFGLDPDNVVIPVVTTLGDVFGVLFLILVARLV 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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