second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  206 ASELGEDLLKLYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGT 285
Cdd:cd18286      1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1516111282  286 LDFPDKANVGHILNMADMYGLEGLKEVAIYILRRDYCNFFQ 326
Cdd:cd18286     81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1516111282  333 LASILECLIIAHSVGVESLFADCMKWIVKHFARFWSERSFANVPPEIQKSCLNMLIQSLNDKN 395
Cdd:cd18490      2 LAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1516111282  424 SQLQEECIAFIIENFSKIIQSENFALLLQsqamsstsDLLDKILKAIEENITTEN 478
Cdd:cd18490     18 EDLYEKCLRWIAKHFAKVWSTKSFASLPP--------ELQEKCYEALVSSLTIEN 64

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  206 ASELGEDLLKLYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGT 285
Cdd:cd18286      1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1516111282  286 LDFPDKANVGHILNMADMYGLEGLKEVAIYILRRDYCNFFQ 326
Cdd:cd18286     81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1516111282  333 LASILECLIIAHSVGVESLFADCMKWIVKHFARFWSERSFANVPPEIQKSCLNMLIQSLNDKN 395
Cdd:cd18490      2 LAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282   224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKaNVGHILNMADM 303
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVEELLELADY 79

                            90
                    ....*....|....*..
gi 1516111282   304 YGLEGLKEVAIYILRRD 320
Cdd:smart00225   80 LQIPGLVELCEEFLLKL 96

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1516111282   48 LLRLLREEVHTDVTFSIGCTLFKAHKAVLLARVPdfYFHT--VGHTNNLTNHEpVAVENFEASEFRIFLQTVYSS 120
Cdd:pfam00651    1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSP--YFKAlfSGQESESSVSE-ITLDDVSPEDFEALLEFMYTG 72

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1516111282  424 SQLQEECIAFIIENFSKIIQSENFALLLQsqamsstsDLLDKILKAIEENITTEN 478
Cdd:cd18490     18 EDLYEKCLRWIAKHFAKVWSTKSFASLPP--------ELQEKCYEALVSSLTIEN 64

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  206 ASELGEDLLKLYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGT 285
Cdd:cd18286      1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1516111282  286 LDFPDKANVGHILNMADMYGLEGLKEVAIYILRRDYCNFFQ 326
Cdd:cd18286     81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1516111282  333 LASILECLIIAHSVGVESLFADCMKWIVKHFARFWSERSFANVPPEIQKSCLNMLIQSLNDKN 395
Cdd:cd18490      2 LAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLdfPDKANVGHILNMADM 303
Cdd:pfam00651   12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL--ISEENVDDLLAAADK 89

                           90
                   ....*....|....
gi 1516111282  304 YGLEGLKEVAIYIL 317
Cdd:pfam00651   90 LQIPSLVDKCEEFL 103

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1516111282 1763 DTLNRWSELTSPFDDSSASITMASFSSEDC-SPQGEWTILELETQH 1807
Cdd:pfam15363    1 DTWSRWSELSSPLDDSSASITVTSFSPEDGcSPQGEWTILELETQH 46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHILNMADM 303
Cdd:cd18265     25 DVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRI-QEDNVESVLEASDL 103

                           90       100
                   ....*....|....*....|..
gi 1516111282  304 YGLEGLKEVAIYIL--RRDYCN 323
Cdd:cd18265    104 LQVSKLREACVRFLegQLHPCN 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHILNMADM 303
Cdd:cd18256     22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV-TVSNVQELLVAADM 100

                           90
                   ....*....|....*.
gi 1516111282  304 YGLEGLKEVAIYILRR 319
Cdd:cd18256    101 LQLTEVVEICCEFLKG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKANVGhILNMADM 303
Cdd:cd18298     14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIG-LLDLANS 92

                           90
                   ....*....|....*.
gi 1516111282  304 YGLEGLKEVAIYILRR 319
Cdd:cd18298     93 YCEERLKKLCEDIIKQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  209 LGEDLLKLYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLdf 288
Cdd:cd18280      1 LGQHFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDEL-- 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1516111282  289 PDKAN-------------VGHILNMADMYGLEGLK 310
Cdd:cd18280     79 PDDVEpagsdsssldttmAQHLLAAADRYALERLR 113

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  229 VDGKSFKAHRAILSARSSYFAAMLSGCWAE-SSQEYITLQGISHVeMNVLIHFIYGGT-LDFPDKANVGHILN---MADM 303
Cdd:cd18302     13 EDGKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMPIPSDI-LEIILDYLYTDEaSAVKESQNVEFLCNvlvIADQ 91

                   ....*....
gi 1516111282  304 YGLEGLKEV 312
Cdd:cd18302     92 LLITRLKEI 100

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1516111282  211 EDLLKLYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLD 287
Cdd:cd18295      8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLE 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLdFPDKANVGHILNMADM 303
Cdd:cd18257     20 DVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTV-FISQATVESLLPAANL 98

                           90       100
                   ....*....|....*....|...
gi 1516111282  304 YGLEGLKevaiyilrRDYCNFFQ 326
Cdd:cd18257     99 LQIKLVL--------KECCDFLE 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  219 KQCCpDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHIL 298
Cdd:cd18240     15 GKLC-DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPI-TAENVEELL 92

                           90
                   ....*....|...
gi 1516111282  299 NMADMYGLEGLKE 311
Cdd:cd18240     93 PAADQFNIMGIVK 105

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1516111282  216 LYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTL 286
Cdd:cd18263      7 LWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGIL 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  205 PASELGEDLLKLYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGG 284
Cdd:cd18343      4 PECRLAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 83

                           90       100
                   ....*....|....*....|....*.
gi 1516111282  285 TLDFPDKAnVGHILNMADMYGLEGLK 310
Cdd:cd18343     84 KAPNLDKM-ADNLLAAADKYALERLK 108

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  219 KQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKANVGHIL 298
Cdd:cd18300      6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGDCVGLI 85

                           90       100
                   ....*....|....*....|.
gi 1516111282  299 NMADMYGLEGLKE-VAIYILR 318
Cdd:cd18300     86 VLANRLCLPRLVAlCEQYIVK 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  219 KQCcpDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHIL 298
Cdd:cd18247     18 KLC--DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAI-DTSNVQSLL 94

                           90
                   ....*....|...
gi 1516111282  299 NMADMYGLEGLKE 311
Cdd:cd18247     95 VGASFLQLQSVKD 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGG--TLDFpdkANVGHILNMA 301
Cdd:cd18255     20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSelTLDL---DCIQDVLGAA 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1516111282  232 KSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKaNVGHILNMADMY 304
Cdd:cd18248     35 EEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEK-CVLHVLPGAVMY 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHILNMADM 303
Cdd:cd18249     25 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITV-EEGNVQTLLPAACL 103

                           90
                   ....*....|....*.
gi 1516111282  304 YGLEGLKEVAIYILRR 319
Cdd:cd18249    104 LQLAEIQEVCCEFLKR 119

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGcWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFPDKaNVGHILNMADM 303
Cdd:cd18315      3 DVTLACEGGSLKAHKLVLAAASPYFAALLKE-TPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQE-QLESLLKLAEL 80

                   ....*
gi 1516111282  304 YGLEG 308
Cdd:cd18315     81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1516111282  224 DIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHILNMA 301
Cdd:cd18251     25 DVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELEL-SLDNVQETLTAA 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  219 KQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYGGTLDFpDKANVGHIL 298
Cdd:cd18253     15 SRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKI-TTENVQYLF 93

                           90       100
                   ....*....|....*....|....*..
gi 1516111282  299 NMADMYGLEGLKEVAIYILRR--DYCN 323
Cdd:cd18253     94 ETSSLFQISPLRDACAKFLEEqlDPCN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  211 EDLLKLYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLS-GCWAESSQEYITLQgishvE-------MNVLIHFIY 282
Cdd:cd18292      6 QDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIELV-----EdpecaavFEKFLRYLY 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1516111282  283 GGTLdFPDKANVGHILNMADMYGLEGLKEV 312
Cdd:cd18292     81 TGQI-SVNLETALPLLMLADKYNVTDLKQL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516111282  204 EPASELGEDLLKLYVKQCCPDIDIYVDGKSFKAHRAILSARSSYFAAMLSGCWAESSQEYITLQGISHVEMNVLIHFIYG 283
Cdd:cd18344      5 DPRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYT 84