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Conserved domains on  [gi|1694585346|ref|XP_029464481|]
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trafficking protein particle complex subunit 2-like protein [Rhinatrema bivittatum]

Protein Classification

trafficking protein particle complex subunit 2-like protein( domain architecture ID 13000929)

trafficking protein particle complex subunit 2-like protein (TRAPPC2L) plays a role in vesicular transport from endoplasmic reticulum to Golgi

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 8-140 2.52e-74

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


:

Pssm-ID: 341444  Cd Length: 135  Bit Score: 217.84  E-value: 2.52e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346   8 VCVAVIAKENYPLYIRSVP--TENELKFHYTVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 85
Cdd:cd14854     1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1694585346  86 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFDNMVTSMM 140
Cdd:cd14854    80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPITSKKFDRRVDSLV 134
 
Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 8-140 2.52e-74

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 217.84  E-value: 2.52e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346   8 VCVAVIAKENYPLYIRSVP--TENELKFHYTVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 85
Cdd:cd14854     1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1694585346  86 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFDNMVTSMM 140
Cdd:cd14854    80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPITSKKFDRRVDSLV 134
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 12-140 1.84e-45

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 144.33  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346  12 VIAKENYPLYIRSVPTENELK-------FHYTVHTSLDVVDEKISAmgkalvdQRELYLGLLYPTEDYKVYGYVTNSKVK 84
Cdd:pfam04628   1 IIGKKDNPLYEQEFSTSGQTEdkehkhlNQFIAHASLDIVDELQWK-------TNNMYLGTIDKFYKLSVSAYVTNSHIK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1694585346  85 FVMVVDSSNtaLRDNEIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFDNMVTSMM 140
Cdd:pfam04628  74 FILVHESST--KSDENIKQFFQEVHELYVKTLMNPFYKPNDPIRSPAFDKKVRKLA 127
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
6-139 3.19e-14

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 64.93  E-value: 3.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346   6 MAVCVAVIAKENYPLYIRSVPTENELKF--------HYTVHTSLDVVDEKISAMGKAlvdqrelYLGLLYPTEDYKVYGY 77
Cdd:COG5603     1 MGEYLAIIGEKDNPVYEREYDPINKTSDgeycrllnQFIIHASLDIVVWLQWSVNTS-------YFDCLDSFGDLRISAY 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1694585346  78 VTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFDNMVTSM 139
Cdd:COG5603    74 IMPSGMKFLFIHQNQS----RKNARSFLQEVHELYAKTLMSPFYEPDEPIRSQAFDDGVREA 131
 
Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 8-140 2.52e-74

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 217.84  E-value: 2.52e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346   8 VCVAVIAKENYPLYIRSVP--TENELKFHYTVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 85
Cdd:cd14854     1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1694585346  86 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFDNMVTSMM 140
Cdd:cd14854    80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPITSKKFDRRVDSLV 134
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 12-140 1.84e-45

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 144.33  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346  12 VIAKENYPLYIRSVPTENELK-------FHYTVHTSLDVVDEKISAmgkalvdQRELYLGLLYPTEDYKVYGYVTNSKVK 84
Cdd:pfam04628   1 IIGKKDNPLYEQEFSTSGQTEdkehkhlNQFIAHASLDIVDELQWK-------TNNMYLGTIDKFYKLSVSAYVTNSHIK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1694585346  85 FVMVVDSSNtaLRDNEIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFDNMVTSMM 140
Cdd:pfam04628  74 FILVHESST--KSDENIKQFFQEVHELYVKTLMNPFYKPNDPIRSPAFDKKVRKLA 127
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 8-139 5.03e-22

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 84.84  E-value: 5.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346   8 VCVAVIAKENYPLYIRS--------VPTENELKFHYTVHTSLDVVDEKISamgkalvDQRELYLGLLYPTEDYKVYGYVT 79
Cdd:cd14853     1 FYFVVVGHHGNPLYEREftppgqaeDDNEEEYKLLAGMLHSVRSINSKLS-------PNVEKYLKLSDKTNEYKVHAYVT 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346  80 NSKVKFVMVVDSSNTALRDNeIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFDNMVTSM 139
Cdd:cd14853    74 ATGLKFVMLTDVLMDRIEDV-LKNFFSDLYVLYVKKNPNPFYEPNSPIRSRLFDSKVQSL 132
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 11-133 1.32e-17

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 73.72  E-value: 1.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346  11 AVIAKENYPLYIRSVPTENELKF--------HYTVHTSLDVVDEKISAMGKalvdqreLYLGLLYPTEDYKVYGYVTNSK 82
Cdd:cd14825     5 VIVGPNDNPLYEAEFGSSKKSEFrddhrhlnQFIAHAALDLVDELQWTTNN-------MYLKSVDRFNEWSVSAFVTAGN 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1694585346  83 VKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFD 133
Cdd:cd14825    78 IRFLLLHDNKN----DDGIKNFFQEVYELYVKILMNPFYEPNTPIRSPAFD 124
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
6-139 3.19e-14

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 64.93  E-value: 3.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346   6 MAVCVAVIAKENYPLYIRSVPTENELKF--------HYTVHTSLDVVDEKISAMGKAlvdqrelYLGLLYPTEDYKVYGY 77
Cdd:COG5603     1 MGEYLAIIGEKDNPVYEREYDPINKTSDgeycrllnQFIIHASLDIVVWLQWSVNTS-------YFDCLDSFGDLRISAY 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1694585346  78 VTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDPIQSRAFDNMVTSM 139
Cdd:COG5603    74 IMPSGMKFLFIHQNQS----RKNARSFLQEVHELYAKTLMSPFYEPDEPIRSQAFDDGVREA 131
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 22-134 2.78e-08

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 49.23  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346  22 IRSVPTENELKFHYTVHTSLDVVDEKISAM-GKALVdqrelylgLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDne 100
Cdd:pfam04099  23 KKTKLTTNEYKLLAGMLHSLHSISSKISPLpGSSGI--------ESLETDTFKLHCLETLTGIKFVLVTDPGTGINRD-- 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1694585346 101 irSMFRKLHNSYTD-VMCNPFYNPGDPIQSRAFDN 134
Cdd:pfam04099  93 --SLLRKYYELYSDyVLKNPFYSLGMPIRCELFDE 125
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 69-139 7.26e-08

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 47.90  E-value: 7.26e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1694585346  69 TEDYKVYGYVTNSKVKFVMVVDSSNTALRdneirSMFRKLHNSYTD-VMCNPFYNPGDPIQSRAFDNMVTSM 139
Cdd:cd14856    61 TDTFRLHCFQTLTGIKFVLVADPKQPGLD-----ALLRRVYELYADyVLKNPFYELEMPIRCELFDENLQKL 127
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 67-136 3.12e-06

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 43.69  E-value: 3.12e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694585346  67 YPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDnEIRSMFRKLHNSYtdVMCNPFYNPGDPIQSRAFDNMV 136
Cdd:cd14855    63 YTTNKYKLHYYETPTGLKFVLLTDPNVGDLRD-VLQQIYSNIYVEY--VVKNPLYPPGEPITSELFRSKL 129
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
77-140 2.55e-03

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 36.03  E-value: 2.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1694585346  77 YVTNSKVKFVMVVDSSNTALRdneirSMFRKLHNSYTD-VMCNPFYNPGDPIQSRAFDNMVTSMM 140
Cdd:COG5122    72 FQTTTGTKFVFVAEKRTVNAL-----FQLQKIYSLYSDyVTKNPFYSPEMPIQCSLFDEHLKRMF 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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