NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720365036|ref|XP_030101616|]
View 

phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2 [Mus musculus]

Protein Classification

phosphoribosyl pyrophosphate synthase-associated protein( domain architecture ID 11226557)

phosphoribosyl pyrophosphate synthase-associated protein seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 100-284 4.92e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


:

Pssm-ID: 434046  Cd Length: 184  Bit Score: 321.38  E-value: 4.92e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 100 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 179
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 180 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 259
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1720365036 260 VDISMILSEAIRRIHNGESMSYLFR 284
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-59 1.84e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.48  E-value: 1.84e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   1 MDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 59
Cdd:pfam13793  58 PPVNDNLMELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 100-284 4.92e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 321.38  E-value: 4.92e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 100 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 179
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 180 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 259
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1720365036 260 VDISMILSEAIRRIHNGESMSYLFR 284
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 3-284 2.77e-77

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 237.26  E-value: 2.77e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:COG0462    63 VNDNLMELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPV 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIH 159
Cdd:COG0462   143 DHLYAAPLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 160 PSLEIpmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAI 236
Cdd:COG0462   205 IIGDV-----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPI 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1720365036 237 DEVVVTNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:COG0462   265 DELVVTDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-284 1.80e-71

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 222.54  E-value: 1.80e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   1 MDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNI 79
Cdd:TIGR01251  59 APVNDNLMELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDV 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  80 PVDNLRASPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIh 159
Cdd:TIGR01251 139 PVDNLYASPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 160 psleipmlipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEV 239
Cdd:TIGR01251 205 ------------------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEV 266

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720365036 240 VVTNTIPHEIqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:TIGR01251 267 IVTNTIPHEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
3-284 2.24e-71

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 222.30  E-value: 2.24e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PRK01259   60 TNDNLMELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaih 159
Cdd:PRK01259  140 DNLYGSPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV---- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 160 psleipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEV 239
Cdd:PRK01259  200 ---------------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDEL 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720365036 240 VVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:PRK01259  265 VVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-59 1.84e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.48  E-value: 1.84e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   1 MDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 59
Cdd:pfam13793  58 PPVNDNLMELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 100-284 4.92e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 321.38  E-value: 4.92e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 100 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 179
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 180 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 259
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1720365036 260 VDISMILSEAIRRIHNGESMSYLFR 284
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 3-284 2.77e-77

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 237.26  E-value: 2.77e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:COG0462    63 VNDNLMELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPV 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIH 159
Cdd:COG0462   143 DHLYAAPLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 160 PSLEIpmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAI 236
Cdd:COG0462   205 IIGDV-----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPI 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1720365036 237 DEVVVTNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:COG0462   265 DELVVTDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-284 1.80e-71

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 222.54  E-value: 1.80e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   1 MDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNI 79
Cdd:TIGR01251  59 APVNDNLMELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDV 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  80 PVDNLRASPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIh 159
Cdd:TIGR01251 139 PVDNLYASPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 160 psleipmlipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEV 239
Cdd:TIGR01251 205 ------------------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEV 266

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720365036 240 VVTNTIPHEIqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:TIGR01251 267 IVTNTIPHEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
3-284 2.24e-71

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 222.30  E-value: 2.24e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PRK01259   60 TNDNLMELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaih 159
Cdd:PRK01259  140 DNLYGSPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV---- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 160 psleipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEV 239
Cdd:PRK01259  200 ---------------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDEL 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720365036 240 VVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:PRK01259  265 VVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
4-283 2.45e-52

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 173.96  E-value: 2.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   4 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PRK04923   67 AENLMELLVLIDALKRASAASVTAVIPYFGYSRQdRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPV 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPPMVRSVaaihps 161
Cdd:PRK04923  147 DNVYASPLLLADIWRAY-GTDNLIVVSPDVGGVVRARAVAKRL-----------DDADLAIIDKRRPRANVATV------ 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 162 leipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 241
Cdd:PRK04923  209 -------------MNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVV 275

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720365036 242 TNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 283
Cdd:PRK04923  276 TDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
3-283 1.66e-49

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 166.51  E-value: 1.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PRK02269   65 VNDNLMEILIMVDALKRASAESINVVMPYYGYARQdRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSppmvrsvaaihps 161
Cdd:PRK02269  145 DHLMGAPLIADYFDRRGLVGDDVVVVSPDHGGVTRARKLAQFLKTPIAII------------DKRRS------------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 162 lEIPMLIPKekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 241
Cdd:PRK02269  200 -VDKMNTSE---VMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIEKLVV 275

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720365036 242 TNTIPHEIQKLqCPKIKTVDISMILSEAIRRIHNGESMSYLF 283
Cdd:PRK02269  276 LDTIYLPEERL-IDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 3-284 8.69e-49

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 164.10  E-value: 8.69e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PLN02369   51 ANENLMELLIMIDACRRASAKRITAVIPYFGYARAdRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPV 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPpmvrsvaaiHPS 161
Cdd:PLN02369  131 DHVYGQPVILDYLASKTISSPDLVVVSPDVGGVARARAFAKKL-----------SDAPLAIVDKRRQG---------HNV 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 162 LEipmlipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 241
Cdd:PLN02369  191 AE----------VMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIV 260

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1720365036 242 TNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:PLN02369  261 TNTIPVSEKN-YFPQLTVLSVANLLGETIWRVHDDCSVSSIFD 302
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
3-283 1.04e-47

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 161.27  E-value: 1.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PRK03092   49 INKWLMEQLIMIDALKRASAKRITVVLPFYPYARQdKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEIPDyRNAVIVAKSPASAKRAQSFAERLrlgiavihGEAqdaesdlvdgrhspPMvrsvAAIHPS 161
Cdd:PRK03092  129 DHLFAMPLLADYVRDKYDL-DNVTVVSPDAGRVRVAEQWADRL--------GGA--------------PL----AFIHKT 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 162 LEIpmLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 241
Cdd:PRK03092  182 RDP--TVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVV 259

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720365036 242 TNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 283
Cdd:PRK03092  260 TDTLPIPEEK-RFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 3-284 2.24e-46

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 158.75  E-value: 2.24e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSK-QCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PRK02812   81 VNDHLMELLIMVDACRRASARQITAVIPYYGYARaDRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPC 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLRlgiavihgeaqDAESDLVDGRHSPPMVRSVaaihps 161
Cdd:PRK02812  161 DHVYGSPVLLDYLASK--NLEDIVVVSPDVGGVARARAFAKKLN-----------DAPLAIIDKRRQAHNVAEV------ 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 162 leipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 241
Cdd:PRK02812  222 -------------LNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIV 288

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1720365036 242 TNTIPHEiQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:PRK02812  289 TNTIPVP-EERRFPQLKVLSVANMLGEAIWRIHEESSVSSMFR 330
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 3-284 1.09e-45

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 156.44  E-value: 1.09e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PRK02458   69 VNDHLWELLIMIDACKRASANTVNVVLPYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDlvDGrhsppmvrsvaaihps 161
Cdd:PRK02458  149 DNLFTVPLFAKHYCKKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSERE--EG---------------- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 162 leipmlipkekppiTVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 241
Cdd:PRK02458  211 --------------YIIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILV 276

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1720365036 242 TNTIpheIQKLQCPK-IKTVDISMILSEAIRRIHNGESMSYLFR 284
Cdd:PRK02458  277 TDSV---ATKERVPKnVTYLSASELIADAIIRIHERKPLSPLFA 317
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 3-283 7.10e-44

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 154.64  E-value: 7.10e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFN--I 79
Cdd:PTZ00145  179 VNENLIELLLMISTCRRASAKKITAVIPYYGYARQdRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprV 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  80 PVDNLRASPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLrlgiavIHGEAQDAEsdlvdgrhsppmvrsvaaih 159
Cdd:PTZ00145  259 PVDNLEAQLIGLDYFTKK--DLYKPVIVSPDAGGVYRARKFQDGL------NHRGISDCG-------------------- 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 160 psleIPMLI-----PKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEES 234
Cdd:PTZ00145  311 ----IAMLIkqrtkPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEAS 386

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1720365036 235 AIDEVVVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 283
Cdd:PTZ00145  387 PLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 3-283 5.14e-42

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 147.37  E-value: 5.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   3 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 81
Cdd:PRK00553   69 VNDSLMELLIAIDALKRGSAKSITAILPYYGYARQdRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  82 DNLRASPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSvaaihps 161
Cdd:PRK00553  149 DILRTYHVFLSRVLELL-GKKDLVVVSPDYGGVKRARLIAESLELPLAII------------DKRRPKHNVAE------- 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 162 leipmlipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEES----AID 237
Cdd:PRK00553  209 ------------SINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAfkkkLID 276

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1720365036 238 EVVVTNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 283
Cdd:PRK00553  277 KLFVSNSIPQTKFE-KKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 4-252 1.97e-25

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 102.30  E-value: 1.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   4 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMcKAGLTHLITMDLHQKEIQGFFNIPVD 82
Cdd:PRK00934   59 DENLVELLLLIDALRDEGAKSITLVIPYLGYARQDKRFKPGePISARAIAKII-SAYYDRIITINIHEPSILEFFPIPFI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  83 NLRASPFLLQYIQEeipDYRNAVIVAKSPASAKRAQSFAERLrlGIAVIHGEAQdaesdlvdgRHSPPMVRsvaaIHPSl 162
Cdd:PRK00934  138 NLDAAPLIAEYIGD---KLDDPLVLAPDKGALELAKEAAEIL--GCEYDYLEKT---------RISPTEVE----IAPK- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 163 EIpmlipkekppitvvgDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVT 242
Cdd:PRK00934  199 NL---------------DVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVT 263

                         250
                  ....*....|
gi 1720365036 243 NTIPHEIQKL 252
Cdd:PRK00934  264 DTLESEVSKI 273
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-59 1.84e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.48  E-value: 1.84e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   1 MDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 59
Cdd:pfam13793  58 PPVNDNLMELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 1-285 4.03e-19

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 86.16  E-value: 4.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   1 MDVNTTIMELLIMVYACKTScAKSIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIP 80
Cdd:PRK06827  102 MSPDDHFQDLKRTIDAIRGK-ARRITVIMPFLYESRQHKRKGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLM 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  81 -VDNLRASPFLLQYIQEEIPDYR----NAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaQDaESDLVDGRHsppmvrsv 155
Cdd:PRK06827  181 gFENLYPSYQIIKALLKNEKDLEidkdHLMVISPDTGAMDRAKYYASVLGVDLGLFYKR-RD-YSRVVNGRN-------- 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 156 aaihpsleipmlipkekpPITVV----GDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLsSDAPRLI 231
Cdd:PRK06827  251 ------------------PIVAHeflgRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVAATFGFF-TNGLEKF 311

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720365036 232 ----EESAIDEVVVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFRN 285
Cdd:PRK06827  312 dkayEEGYFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKLLDP 369
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
4-272 1.16e-09

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 58.03  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   4 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVS-----KLLAsmmckAGLTHLITMD--LHQ-KEIQG 75
Cdd:PRK07199   62 DEKLLPLLFAAEAARELGARRVGLVAPYLAYMRQDIAFHPGEAISqrhfaRLLS-----GSFDRLVTVDphLHRyPSLSE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036  76 FFNIPVDNLRASPFLLQYIQEEIPDyrnAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSV 155
Cdd:PRK07199  137 VYPIPAVVLSAAPAIAAWIRAHVPR---PLLIGPDEESEQWVAAVAERAGAPHAVLRKT-----------RHGD---RDV 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036 156 AaihpsLEIPMLIPKEKPPITVVGDV--GGRiaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEE 233
Cdd:PRK07199  200 E-----ISLPDAAPWAGRTPVLVDDIvsTGR-------------TLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAA 261

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1720365036 234 SAIDEVVVTNTIPHEIQklqcpkikTVDISMILSEAIRR 272
Cdd:PRK07199  262 AGIARVVSTDTVPHPSN--------AISLAPLLAEALRR 292
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 4-120 6.11e-03

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 37.75  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365036   4 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVSKL-LASM-----MCKAGLTHLITMDLHQKEIQGFF 77
Cdd:PLN02297   78 PAVIFEQLSVIYALPKLFVASFTLVLPFFPTGTSERVEREGDVATAFtLARIlsnipISRGGPTSLVIFDIHALQERFYF 157

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1720365036  78 NipvDNLRAS-----PFLLQYIQeEIPDYRNAVIVAKSPASAKRAQSF 120
Cdd:PLN02297  158 G---DNVLPCfesgiPLLKKRLQ-QLPDSDNIVIAFPDDGAWKRFHKQ 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH