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Conserved domains on  [gi|1756842681|ref|XP_030912195|]
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plexin-B1 isoform X2 [Geospiza fortis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 27-489 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 935.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   27 FSHNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQ 106
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  107 KELIVCGSVHQGICEKRSLESIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGVGGGIPPIT 186
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  187 TRNLRAHGGDvqATDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 266
Cdd:cd11275    161 TRNLRAHGDD--ATDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  267 YSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11275    239 YSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLDTDGEVLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTR 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVNVEDGHT 426
Cdd:cd11275    319 DVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVEDGHT 398

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756842681  427 IAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPIM 489
Cdd:cd11275    399 IAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1626-2116 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


:

Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 819.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQRDLDIP---ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVA 1702
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1703 SLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1781
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1782 VDKGPVDWVTGKAKYTLNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPY 1861
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG------ENSESVPVKVLDCDTITQVKEKILDAIYKNTPY 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1862 CHRPDPDTLDLEWRSGLAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVALVPrltkhihrenqdyipgektpmle 1941
Cdd:pfam08337  235 SQRPSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP----------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1942 dadeggiKLWHLVKPTEEPELPKHrrgslrDRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-NRPVPLAVKYFF 2020
Cdd:pfam08337  292 -------KYWHLVKPSDEGDQRKK------SERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2021 DLLDEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2100
Cdd:pfam08337  359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438

                          490
                   ....*....|....*.
gi 1756842681 2101 LLYARDIPRYKQMVER 2116
Cdd:pfam08337  439 LLYAKDIPRYKQMVER 454
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1135-1226 4.87e-28

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 109.33  E-value: 4.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1135 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIAETVTVAGIPCAVDAQEYEISSSIVCVTGGSWTERFGHiVVEVPGGG 1214
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNG-PVEVTVGH 79

                           90
                   ....*....|....*
gi 1756842681 1215 ---RGVSGHVFTYQN 1226
Cdd:cd01180     80 gsfRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 549-636 1.11e-26

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.43  E-value: 1.11e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  549 TPANISREEKRNIFLAISDLPSLreEEFYSCYFEDY-ESPAVLTESGIMCPSPDPSQAPALPTGTDHVTIKLVVRF--HD 625
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTG 78

                           90
                   ....*....|.
gi 1756842681  626 IFIASVDFSFY 636
Cdd:pfam17960   79 VDFASTNFTFY 89
TIG_2 super family cl39440
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 988-1087 8.57e-23

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


The actual alignment was detected with superfamily member pfam18020:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 94.65  E-value: 8.57e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  988 GSSLFPVNVARKITLLGKNFHLYQDQQWDYECVLNLEGRTVVMEAYVEGEETnkslcyITCQMNQYSYTAPQLEFNAVVF 1067
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDS------ITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 1756842681 1068 VQRRRHLRVDSAADLHVTFY 1087
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1317-1439 5.48e-20

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01181:

Pssm-ID: 472823  Cd Length: 99  Bit Score: 86.70  E-value: 5.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1317 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVspserrrrgvgrwrrivpdsecpegslcsIQQFEEPCLVNSS 1396
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKY-----------------------------GGVEKTSCKVRNS 51

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1756842681 1397 YLILCKTPAINLLLRS---VRIKLEFILDNLSF-DFNSLHPMPFSYE 1439
Cdd:cd01181     52 TLMTCPAPSLALLNRSpepGERPVEFGLDGDNVqSLLILNRTSFSYY 98
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1227-1314 3.57e-17

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01179:

Pssm-ID: 472823  Cd Length: 85  Bit Score: 78.03  E-value: 3.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1227 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLLGDLPCKILSEmTEDQLACQTSPSNVSTELPVTIKYGeQERRL 1306
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAG--SSVRVTVGGQPCKILSV-SSSQIVCLTPPSASPGEAPVKVLID-GARRL 76


                   ....*...
gi 1756842681 1307 EGSLFRYT 1314
Cdd:cd01179     77 APLVFTYT 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 491-540 3.38e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 65.81  E-value: 3.38e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1756842681  491 CSLYLDCESCLAVKDPYCGWCVLQGRCSRRSECLRSRlSEQWLWSFNSTQ 540
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSK 50
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 688-905 7.27e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 7.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  688 IPISIVHPSSAAPLTKSSTAAPTMATKPVTtPVHVGPSTVPHTEAIHVTPSAAWEATTEPAqsPSYTRLSLPTEGASLQA 767
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPAT-PGGPARPARPPTTAGPPAPAPPAAPAAGPP--RRLTRPAVASLSESRES 2797

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  768 ATEAPLPPPADNPV-----TVPETTSPAAPVFSSPSknmdhiALPTeGPATAQEArhTDPPTTLGGS----------PLH 832
Cdd:PHA03247  2798 LPSPWDPADPPAAVlapaaALPPAASPAGPLPPPTS------AQPT-APPPPPGP--PPPSLPLGGSvapggdvrrrPPS 2868

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1756842681  833 TSPVAAVTLSPHVTSFKWP-PSPFPTTEALTSAISSPQTPSQvPGSPvvsdddTPGSPGTELPVSGLPTSAPPQ 905
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLArPAVSRSTESFALPPDQPERPPQ-PQAP------PPPQPQPQPPPPPQPQPPPPP 2935
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
1088-1133 6.95e-05

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 42.15  E-value: 6.95e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1088 NCSVgHTDCSRCQTADSKYnCVWCGGDNpSCIFRGSCKEEIEDL----CP 1133
Cdd:smart00423    1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSRRQNWlsggCP 47
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
650-677 6.69e-03

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 36.37  E-value: 6.69e-03
                            10        20
                    ....*....|....*....|....*....
gi 1756842681   650 CQKCVSSLWG-CNWCIQQHLCTHKATCEE 677
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDS 36
 
Name Accession Description Interval E-value
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 27-489 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 935.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   27 FSHNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQ 106
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  107 KELIVCGSVHQGICEKRSLESIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGVGGGIPPIT 186
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  187 TRNLRAHGGDvqATDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 266
Cdd:cd11275    161 TRNLRAHGDD--ATDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  267 YSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11275    239 YSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLDTDGEVLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTR 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVNVEDGHT 426
Cdd:cd11275    319 DVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVEDGHT 398

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756842681  427 IAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPIM 489
Cdd:cd11275    399 IAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1626-2116 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 819.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQRDLDIP---ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVA 1702
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1703 SLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1781
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1782 VDKGPVDWVTGKAKYTLNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPY 1861
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG------ENSESVPVKVLDCDTITQVKEKILDAIYKNTPY 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1862 CHRPDPDTLDLEWRSGLAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVALVPrltkhihrenqdyipgektpmle 1941
Cdd:pfam08337  235 SQRPSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP----------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1942 dadeggiKLWHLVKPTEEPELPKHrrgslrDRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-NRPVPLAVKYFF 2020
Cdd:pfam08337  292 -------KYWHLVKPSDEGDQRKK------SERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2021 DLLDEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2100
Cdd:pfam08337  359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438

                          490
                   ....*....|....*.
gi 1756842681 2101 LLYARDIPRYKQMVER 2116
Cdd:pfam08337  439 LLYAKDIPRYKQMVER 454
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1626-2116 0e+00

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 622.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1705
Cdd:cd12793      1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1706 TVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDKG 1785
Cdd:cd12793     81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1786 PVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychrp 1865
Cdd:cd12793    161 PVDAVTGK------------------------------------------------------------------------ 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1866 dpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledade 1945
Cdd:cd12793        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1946 ggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDE 2025
Cdd:cd12793    169 ----------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDE 220

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2026 QAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLYAR 2105
Cdd:cd12793    221 QALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYAR 300

                          490
                   ....*....|.
gi 1756842681 2106 DIPRYKQMVER 2116
Cdd:cd12793    301 DIPRYKQMVER 311
Sema smart00630
semaphorin domain;
34-456 8.82e-69

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 237.65  E-value: 8.82e-69
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681    34 FLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKlecPQAHHTDNHNKL-LLVNTVQKELIVC 112
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIrLLLDYNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   113 GS-VHQGICEKRSLESidhvlfrpespgdtqyvaandpnittvgliayskdevplLFVGRGYTSRGVGGGIPP-ITTRNL 190
Cdd:smart00630   78 GTnAFQPVCRLRNLGE---------------------------------------LYVGTVADFSGSDPAIPRsLSVRRL 118

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   191 RAHGGDVQATDSHSIFSYeetaklavgrlseYNHHFIKSFTYHSSVYFLFYRR--DLKSQSREYKTYISRICLDD----- 263
Cdd:smart00630  119 KGTSGVSLRTVLYDSKWL-------------NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggpr 185

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   264 ---SHYYSYVELPLLCQSKANT---YSLLQAAYVTRPGKElaqgqldtEGEVLFAAFSAWQASSGKlseeSALCVYTMEE 337
Cdd:smart00630  186 sldKKWTSFLKARLECSVPGEDpfyFNELQAAFLLPPGSE--------SDDVLYGVFSTSSNPIPG----SAVCAFSLSD 253

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   338 VDRLTNWTRDVCYMRDGKSEEGTEvAYIEYDVSSNCVQLPADTLyAYPC----GSDHTPSPMASRVPLEAAPLLEKT--E 411
Cdd:smart00630  254 INAVFNGPFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSK-DLPDetlnFIKSHPLMDEVVQPLTGRPLFVKTdsN 331

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1756842681   412 ARLTAVAVNVED---GHTIAFLGDSRGRLHKVYL---GAQGEAHTYASVSI 456
Cdd:smart00630  332 YLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLsesSSSSESVVLEEISV 382
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1135-1226 4.87e-28

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 109.33  E-value: 4.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1135 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIAETVTVAGIPCAVDAQEYEISSSIVCVTGGSWTERFGHiVVEVPGGG 1214
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNG-PVEVTVGH 79

                           90
                   ....*....|....*
gi 1756842681 1215 ---RGVSGHVFTYQN 1226
Cdd:cd01180     80 gsfRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 549-636 1.11e-26

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.43  E-value: 1.11e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  549 TPANISREEKRNIFLAISDLPSLreEEFYSCYFEDY-ESPAVLTESGIMCPSPDPSQAPALPTGTDHVTIKLVVRF--HD 625
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTG 78

                           90
                   ....*....|.
gi 1756842681  626 IFIASVDFSFY 636
Cdd:pfam17960   79 VDFASTNFTFY 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 286-469 1.70e-25

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 105.43  E-value: 1.70e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  286 LQAAYVTRPGKELAQGqldtegEVLFAAFSAWQASSgklSEESALCVYTMEEVDRLTNwTRDVCYMRDGkSEEGTEVAYI 365
Cdd:pfam01403    1 LQDVFVLKPGAGDALD------TVLYGVFTTQWSNS---IGGSAVCAFSLSDINAVFE-GPFKEQEKSD-SKWLPYTGKV 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  366 EYDVSSNCV------QLPADTLyaypCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVN---VEDG-HTIAFLGDSRG 435
Cdd:pfam01403   70 PYPRPGTCIndplrlDLPDSVL----NFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDrvqALDGnYTVLFLGTDDG 145

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1756842681  436 RLHKVYLGAQGEAHTYASVSI-QVNSMVSGDLLFD 469
Cdd:pfam01403  146 RLHKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 988-1087 8.57e-23

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 94.65  E-value: 8.57e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  988 GSSLFPVNVARKITLLGKNFHLYQDQQWDYECVLNLEGRTVVMEAYVEGEETnkslcyITCQMNQYSYTAPQLEFNAVVF 1067
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDS------ITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 1756842681 1068 VQRRRHLRVDSAADLHVTFY 1087
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1317-1439 5.48e-20

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 86.70  E-value: 5.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1317 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVspserrrrgvgrwrrivpdsecpegslcsIQQFEEPCLVNSS 1396
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKY-----------------------------GGVEKTSCKVRNS 51

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1756842681 1397 YLILCKTPAINLLLRS---VRIKLEFILDNLSF-DFNSLHPMPFSYE 1439
Cdd:cd01181     52 TLMTCPAPSLALLNRSpepGERPVEFGLDGDNVqSLLILNRTSFSYY 98
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1227-1314 3.57e-17

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 78.03  E-value: 3.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1227 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLLGDLPCKILSEmTEDQLACQTSPSNVSTELPVTIKYGeQERRL 1306
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAG--SSVRVTVGGQPCKILSV-SSSQIVCLTPPSASPGEAPVKVLID-GARRL 76


                   ....*...
gi 1756842681 1307 EGSLFRYT 1314
Cdd:cd01179     77 APLVFTYT 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1135-1224 5.28e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 69.01  E-value: 5.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1135 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIaeTVTVAGIPCAVDAQeyeISSSIVCVTGGSWTERFGhIVVEVPGGG 1214
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISV---SSTTIVCTTPPGTSGLVN-VSVTVGGGG 74

                           90
                   ....*....|
gi 1756842681 1215 RGVSGHVFTY 1224
Cdd:pfam01833   75 ISSSPLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 491-540 3.38e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 65.81  E-value: 3.38e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1756842681  491 CSLYLDCESCLAVKDPYCGWCVLQGRCSRRSECLRSRlSEQWLWSFNSTQ 540
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSK 50
IPT smart00429
ig-like, plexins, transcription factors;
1135-1224 8.51e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 65.90  E-value: 8.51e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1135 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIAETVTVAGIPCAVDAQEyeiSSSIVCVTGGSWTERFGHIVVEVPGGG 1214
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77

                            90
                    ....*....|..
gi 1756842681  1215 RGVSG--HVFTY 1224
Cdd:smart00429   78 GGVPSspQPFTY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
490-527 9.17e-12

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 61.41  E-value: 9.17e-12
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1756842681   490 ECSLYLDCESCLAVKDPYCGWCVLQGRCSRRSECLRSR 527
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRR 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-905 7.27e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 7.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  688 IPISIVHPSSAAPLTKSSTAAPTMATKPVTtPVHVGPSTVPHTEAIHVTPSAAWEATTEPAqsPSYTRLSLPTEGASLQA 767
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPAT-PGGPARPARPPTTAGPPAPAPPAAPAAGPP--RRLTRPAVASLSESRES 2797

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  768 ATEAPLPPPADNPV-----TVPETTSPAAPVFSSPSknmdhiALPTeGPATAQEArhTDPPTTLGGS----------PLH 832
Cdd:PHA03247  2798 LPSPWDPADPPAAVlapaaALPPAASPAGPLPPPTS------AQPT-APPPPPGP--PPPSLPLGGSvapggdvrrrPPS 2868

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1756842681  833 TSPVAAVTLSPHVTSFKWP-PSPFPTTEALTSAISSPQTPSQvPGSPvvsdddTPGSPGTELPVSGLPTSAPPQ 905
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLArPAVSRSTESFALPPDQPERPPQ-PQAP------PPPQPQPQPPPPPQPQPPPPP 2935
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 689-1001 8.36e-11

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 66.91  E-value: 8.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  689 PISIVHPSSAAPLTKSSTAAPTMA-TKPVT----TPVHVGPST-VPHTEAIHV-TPSAAWEATTEPAQSPSYTRLSLPTE 761
Cdd:pfam17823  118 AASSSPSSAAQSLPAAIAALPSEAfSAPRAaacrANASAAPRAaIAAASAPHAaSPAPRTAASSTTAASSTTAASSAPTT 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  762 GASLQAATEAPLPP---PADNPVTVPETTSPAAPVFSSPSKNMDHIALPTEGPAT-AQEARHTDPPTTLGGSPLHTSPVA 837
Cdd:pfam17823  198 AASSAPATLTPARGistAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAAlATLAAAAGTVASAAGTINMGDPHA 277

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  838 AvTLSP--HVTSFKWPPSPFPT----TEALTSAISSPQTPSQVPGSPVVSDDDTPGSPGTelPVSGLPTSAPPQWLTELQ 911
Cdd:pfam17823  278 R-RLSPakHMPSDTMARNPAAPmgaqAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNT--PKSVASTNLAVVTTTKAQ 354

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  912 DTEDwmdllqaendtslfSASTllsgdgdsserdVPDFPRILHPDLdyqydapefweESEEPSWGPNACPCVQGIQGSS- 990
Cdd:pfam17823  355 AKEP--------------SASP------------VPVLHTSMIPEV-----------EATSPTTQPSPLLPTQGAAGPGi 397

                          330
                   ....*....|..
gi 1756842681  991 -LFPVNVARKIT 1001
Cdd:pfam17823  398 lLAPEQVATEAT 409
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1227-1313 1.51e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.60  E-value: 1.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1227 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhPNEISVLLGDLPCKILSeMTEDQLACQTsPSNVSTELPVTIKYGEQERRL 1306
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTD-SSDLKVTIGGTPCTVIS-VSSTTIVCTT-PPGTSGLVNVSVTVGGGGISS 77


                   ....*..
gi 1756842681 1307 EGSLFRY 1313
Cdd:pfam01833   78 SPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1226-1314 1.05e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 51.27  E-value: 1.05e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1226 NPELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNEISVLLGDLPCKILSEmTEDQLACQTSPSNVST-ELPV-TIKYGEQE 1303
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPS-SSTAIVCKTPPYHNIPgSVPVrTVGLRNGG 79

                            90
                    ....*....|.
gi 1756842681  1304 RRLEGSLFRYT 1314
Cdd:smart00429   80 VPSSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
1316-1438 1.06e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 51.27  E-value: 1.06e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1316 DPNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVSpserrrrgvgrwrrivpdsecpeGSLCSIQQfeepclvNS 1395
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVG-----------------------EAPCTFSP-------SS 50

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1756842681  1396 SYLILCKTPAINLLLRSVRI-KLEFILDNLSFDfnslhPMPFSY 1438
Cdd:smart00429   51 STAIVCKTPPYHNIPGSVPVrTVGLRNGGVPSS-----PQPFTY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
1088-1133 6.95e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 42.15  E-value: 6.95e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1088 NCSVgHTDCSRCQTADSKYnCVWCGGDNpSCIFRGSCKEEIEDL----CP 1133
Cdd:smart00423    1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSRRQNWlsggCP 47
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 1088-1127 1.23e-04

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.54  E-value: 1.23e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1756842681 1088 NCSvGHTDCSRCQTADSkYNCVWCGGDNpSCIFRGSCKEE 1127
Cdd:pfam01437    1 RCS-QYTSCSSCLAARD-PYCGWCSSEG-RCVRRSACGAP 37
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
650-677 6.69e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 36.37  E-value: 6.69e-03
                            10        20
                    ....*....|....*....|....*....
gi 1756842681   650 CQKCVSSLWG-CNWCIQQHLCTHKATCEE 677
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDS 36
 
Name Accession Description Interval E-value
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 27-489 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 935.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   27 FSHNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQ 106
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  107 KELIVCGSVHQGICEKRSLESIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGVGGGIPPIT 186
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  187 TRNLRAHGGDvqATDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 266
Cdd:cd11275    161 TRNLRAHGDD--ATDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  267 YSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11275    239 YSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLDTDGEVLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTR 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVNVEDGHT 426
Cdd:cd11275    319 DVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVEDGHT 398

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756842681  427 IAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPIM 489
Cdd:cd11275    399 IAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1626-2116 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 819.13  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQRDLDIP---ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVA 1702
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1703 SLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1781
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1782 VDKGPVDWVTGKAKYTLNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPY 1861
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG------ENSESVPVKVLDCDTITQVKEKILDAIYKNTPY 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1862 CHRPDPDTLDLEWRSGLAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVALVPrltkhihrenqdyipgektpmle 1941
Cdd:pfam08337  235 SQRPSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP----------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1942 dadeggiKLWHLVKPTEEPELPKHrrgslrDRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-NRPVPLAVKYFF 2020
Cdd:pfam08337  292 -------KYWHLVKPSDEGDQRKK------SERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2021 DLLDEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2100
Cdd:pfam08337  359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438

                          490
                   ....*....|....*.
gi 1756842681 2101 LLYARDIPRYKQMVER 2116
Cdd:pfam08337  439 LLYAKDIPRYKQMVER 454
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1626-2116 0e+00

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 622.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1705
Cdd:cd12793      1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1706 TVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDKG 1785
Cdd:cd12793     81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1786 PVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychrp 1865
Cdd:cd12793    161 PVDAVTGK------------------------------------------------------------------------ 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1866 dpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledade 1945
Cdd:cd12793        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1946 ggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDE 2025
Cdd:cd12793    169 ----------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDE 220

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2026 QAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLYAR 2105
Cdd:cd12793    221 QALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYAR 300

                          490
                   ....*....|.
gi 1756842681 2106 DIPRYKQMVER 2116
Cdd:cd12793    301 DIPRYKQMVER 311
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 34-488 0e+00

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 580.35  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   34 FLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQKELIVCG 113
Cdd:cd11245      2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQAKETDNFNKLLLVNSANGTLVVCG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  114 SVHQGICEKRSLESIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGvGGGIPPITTRNLRAH 193
Cdd:cd11245     82 SLFQGVCELRNLNSVNKPLYRPETPGDKQYVAANEPSVSTVGLISYFKDGLSLLFVGRGYTSSL-SGGIPPITTRLLQEH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  194 ggdvqatDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQsREYKTYISRICLDDSHYYSYVELP 273
Cdd:cd11245    161 -------GEMDAFSNEVEAKLVVGSASRYHHDFVYAFADNGYIYFLFSRRPGTAD-STKRTYISRLCENDHHYYSYVELP 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  274 LLCQ-SKANTYSLLQAAYVTRPGKELaqgqldtEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTRDVCYMR 352
Cdd:cd11245    233 LNCTvNQENTYNLVQAAYLAKPGKVL-------NGKVLFGVFSADEASTAAPDGRSALCMYPLSSVDARFERTRESCYTG 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  353 DGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEkTEARLTAVAVNVEDGHTIAFLGD 432
Cdd:cd11245    306 EGLEDDKPETAYIEYNVKSICKTLPDKNVKAYPCGAEHTPSPLASRYPLAAKPILT-RNDMLTAVAVAVENGHTIAFLGD 384

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1756842681  433 SRGRLHKVYLGAqGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11245    385 SGGQLHKVYLDP-NHTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPV 439
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 1626-2116 0e+00

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 562.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQRD--LDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVAS 1703
Cdd:cd12787      1 GIPFLDYKTYAERVFFPGHKDGPLDVMikLDIPEPRRPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1704 LLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1783
Cdd:cd12787     81 LLTVALHGKLEYYTDIMRTLLLDLLAQYVVKNPKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1784 KGPVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1863
Cdd:cd12787    161 KGPVDAVTGK---------------------------------------------------------------------- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1864 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1943
Cdd:cd12787        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1944 deggiklwhlvkpteepelpkhrrgslrdreRAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLL 2023
Cdd:cd12787    171 -------------------------------RAKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGRPVPPAVKYFFDLL 219

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2024 DEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2103
Cdd:cd12787    220 DEQAEKHGIQDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLGRDSPSNKLLY 299

                          490
                   ....*....|...
gi 1756842681 2104 ARDIPRYKQMVER 2116
Cdd:cd12787    300 AREIPRYKKMVER 312
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1626-2116 1.94e-174

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 537.50  E-value: 1.94e-174
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQR--DLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVAS 1703
Cdd:cd12791      1 GIPFLDYRTYAERVFFPGHGGCPLQPslEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1704 LLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1783
Cdd:cd12791     81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1784 KGPVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1863
Cdd:cd12791    161 KGPVDAVTGK---------------------------------------------------------------------- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1864 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1943
Cdd:cd12791        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1944 deggiklwhlvkpteepelpkhrrgslrdRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLL 2023
Cdd:cd12791    171 -----------------------------RERAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPIAVKYLFDFL 221

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2024 DEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2103
Cdd:cd12791    222 DELAEKHGIEDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVGRDSPVNKLLY 301

                          490
                   ....*....|...
gi 1756842681 2104 ARDIPRYKQMVER 2116
Cdd:cd12791    302 AREIPRYKQMVEK 314
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 27-488 8.16e-166

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 515.51  E-value: 8.16e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   27 FSHNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQ 106
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  107 KELIVCGSVHQGICEKRSLESIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDeVPLLFVGRGYTSRGvGGGIPPIT 186
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPG-RDLLLVGRGLTGKL-SAGIPPLT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  187 TRNLRAhggdVQAtdshsiFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQsREYKTYISRICLDDSHY 266
Cdd:cd11277    159 IRQLAG----AQA------FSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQ-AEYRTYVARVCLGDTNL 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  267 YSYVELPLLCQskaNTYSLLQAAYVTRPGKElaqgqldtegevLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11277    228 YSYVEVPLVCQ---GGYNLAQAAYLAPGQGT------------LFVVFAAGQGSTPTPTDQTALCAYPLVELDSAMERAR 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLeKTEARLTAVAVNVEDGHT 426
Cdd:cd11277    293 RLCYTAGGGGPNGKEEATIEYGVTSRCVNLPKDSPESYPCGDEHTPSPIASRQPLEAEPLL-TLTPPLTAVAALQEDGHT 371

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756842681  427 IAFLGDSRGRLHKVYLGAQGeAHTYASVSI-QVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11277    372 IAFLGDTQGQLHKVFLNGSA-GQVYSSQPVgPPGSAVNPDLLLDATGSHLYVLTARQVTKVPV 433
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 1626-2116 4.55e-145

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 455.91  E-value: 4.55e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1705
Cdd:cd12205      1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1706 TVSLHGKLEYFTDILKTLLNDLVEQYVAK-NPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDK 1784
Cdd:cd12205     81 MVALQGKMEYATEILFDLLTDLIEKSVSKkHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIEK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1785 GPVDWVtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychr 1864
Cdd:cd12205    161 GPVDAI-------------------------------------------------------------------------- 166

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1865 pdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledad 1944
Cdd:cd12205        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1945 eggiklwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTN-RPVPLAVKYFFDLL 2023
Cdd:cd12205    167 --------------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILSVPqRSLPPAIKYLFDFL 214

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2024 DEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2103
Cdd:cd12205    215 DEQARKHGISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGKDSPSNKLLF 294

                          490
                   ....*....|...
gi 1756842681 2104 ARDIPRYKQMVER 2116
Cdd:cd12205    295 AKDIPRYREMVAN 307
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
 1626-2115 2.38e-134

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 426.35  E-value: 2.38e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFF----PGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYV 1701
Cdd:cd12792      1 RIPFLDYKTYTDRVFFlpskDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1702 ASLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKH 1780
Cdd:cd12792     81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVhSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1781 QVDKGPVDwvtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtiTQVKEKildqiykgtp 1860
Cdd:cd12792    161 QVEKGPVD--------------------------------------------------------AVQKKK---------- 174

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1861 ychrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpml 1940
Cdd:cd12792        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1941 edadeggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFF 2020
Cdd:cd12792    175 ---------------------------------ERTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSGAVVPPAVKYFF 221

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2021 DLLDEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2100
Cdd:cd12792    222 DFLDEQAEKHDIVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNK 301

                          490
                   ....*....|....*
gi 1756842681 2101 LLYARDIPRYKQMVE 2115
Cdd:cd12792    302 LLYAKEISTYKKMVD 316
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1626-2116 1.97e-126

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 403.34  E-value: 1.97e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1705
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1706 TVSLHGKLEYFTDILKTLLNDLVEQYVAK--NPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1783
Cdd:cd12790     81 MVVLQSKMEYATDILKQLLADLIEKNLESknHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1784 KGPVDWVtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1863
Cdd:cd12790    161 KGPIDAI------------------------------------------------------------------------- 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1864 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1943
Cdd:cd12790        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1944 deggiklwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNR---PVPLAVKYFF 2020
Cdd:cd12790    168 ---------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsALPLAIKYMF 214

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2021 DLLDEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2100
Cdd:cd12790    215 DFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNK 294

                          490
                   ....*....|....*.
gi 1756842681 2101 LLYARDIPRYKQMVER 2116
Cdd:cd12790    295 LLYAKDIPNYKSWVER 310
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 31-488 2.10e-122

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 394.53  E-value: 2.10e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   31 ATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQKELI 110
Cdd:cd11276      5 ATELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSANKTLV 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  111 VCGSVHQGICEKRSLESIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDE-VPLLFVGRGYTSRGVGggiPPITTRN 189
Cdd:cd11276     85 VCGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSLKPGnDRVFFVGKGNGSNDNG---KIISTRL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  190 LrahggdvQATDSHSIF-SYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFyRRDLKSQSREYkTYISRICLDDSHYYS 268
Cdd:cd11276    162 L-------QNYDDREVFeNYIDAATVKSAYVSRYTQQFRYAFEDNNYVYFLF-NQQLGHPDKNR-TLIARLCENDHHYYS 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  269 YVELPLLCQSKANTYSLLQAAYVTRPGKELAQ--GQLDTEGEVLFAAFSAWQASSGklseESALCVYTMEEVDRLTNWTR 346
Cdd:cd11276    233 YTEMDLNCRDGANAYNKCQAAYVSTPGKELAQnyGNSILSDKVLFAVFSRDEKDSG----ESALCMFPLKSINAKMEANR 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  347 DVCYMrdgKSEEGTEVAYIEYDVSSN--CVQLPADTLYAYPCGSDHTPSPMASRVPL-EAAPLLEKTEARLTAVAVNVED 423
Cdd:cd11276    309 EACYT---GTIDDRDVFYKPFHSQKDiiCGSHQQKNSKSFPCGSEHLPYPLGSRDELaLTAPVLQRGGLNLTAVTVAVEN 385

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1756842681  424 GHTIAFLGDSRGRLHKVYLGAQGEAhtYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11276    386 GHTVAFLGTSDGRILKVHLSPDPEE--YNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPV 448
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 34-488 3.15e-115

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 372.05  E-value: 3.15e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   34 FLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQKELIVCG 113
Cdd:cd11236      2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSGRLITCG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  114 SVHQGICEKRSLESIDHVLFRpespgDTQYVAANDPNITTVGLIAYSKD-EVPLLFVGRGYTSRGVGGGIPPITTRNLRa 192
Cdd:cd11236     82 SLYQGVCQLRNLSNISVVVER-----SSTPVAANDPNASTVGFVGPGPYnNENVLYVGATYTNNGYRDYRPAVSSRSLP- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  193 hggdvqATDSHSIFSYEETAKLAVGRLS--EYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHYYSYV 270
Cdd:cd11236    156 ------PDDDFNAGSLTGGSAISIDDEYrdRYSIKYVYGFSSGGFSYFVTVQRKSVDDESPYISRLVRVCQSDSNYYSYT 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  271 ELPLLCQSKANT-YSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRltnwtrdv 348
Cdd:cd11236    230 EVPLQCTGGDGTnYNLLQAAYVGKAGSDLARSlGISTDDDVLFGVFSKSKGPSAEPSSKSALCVFSMKDIEA-------- 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  349 cymrdgkseegtevAYIEYdvssncvqlpadtlyaypcgsdhtpSPMASRVPLEAAPLLEktEARLTAVAVNVEDGHTIA 428
Cdd:cd11236    302 --------------AFNDN-------------------------CPLGGGVPITTSAVLS--DSLLTSVAVTTTRNHTVA 340

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  429 FLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11236    341 FLGTSDGQLKKVVLESSSSATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPV 400
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 1626-2116 3.66e-113

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 366.62  E-value: 3.66e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1626 GIPFLDYKSYAERIFFP-----------------------GHRES-PLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLT 1681
Cdd:cd12788      2 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqennsqgprQVPEThPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFLV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1682 KFIHTLEIQRTFSPRDRAYVASLLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYA 1761
Cdd:cd12788     82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASASKNPKLMLRRTESVVEKMLTNWMSICMYS 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1762 FVRDSVGEPLYMLFRGIKHQVDKGPVDwvtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldc 1841
Cdd:cd12788    162 YLRETVGEPFFLLLCAIKQQINKGSID----------------------------------------------------- 188

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1842 dtitqvkekildqiykgtpychrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprlt 1921
Cdd:cd12788        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1922 khihrenqdyipgektpmledadegGIKlwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDL 2001
Cdd:cd12788    189 -------------------------AIK---------------------------KVLPEIYLTRLLSTKGTLQKFLDDL 216

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2002 FQVILST--NRPvPLAVKYFFDLLDEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQ 2079
Cdd:cd12788    217 FQAILSIpeDRP-PLAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMDACLSVIAQ 295

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1756842681 2080 TFMDSCTIADHKLGRDSPINKLLYARDIPRYKQMVER 2116
Cdd:cd12788    296 AFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQR 332
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 1623-2115 3.77e-96

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 316.81  E-value: 3.77e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1623 VGTgIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQT-VEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYV 1701
Cdd:cd12789      1 FGT-VPFLDYKHFALRTFFPESGGFTHIFTRDDPHDRDQTdKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLF 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1702 ASLLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1781
Cdd:cd12789     80 ASFLTIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1782 VDKGPVDWVTGKAKytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpy 1861
Cdd:cd12789    160 INKGPVDVIKFKVK------------------------------------------------------------------ 173

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1862 chrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmle 1941
Cdd:cd12789        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1942 dadeggiklwhlvkpteepelpkhrrgslrdrerakaipEIYLTRLLSMKGTLQKFVDDLFQVI--LSTNRPvPLAVKYF 2019
Cdd:cd12789    174 ---------------------------------------EMYLTKLLSTKVAIHSVVEKLFRSIwsLPNNKA-PVAIKYF 213

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 2020 FDLLDEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPIN 2099
Cdd:cd12789    214 FDFLDAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGKEAPTN 293

                          490
                   ....*....|....*.
gi 1756842681 2100 KLLYARDIPRYKQMVE 2115
Cdd:cd12789    294 KLLYAKDIPQYKEEVK 309
Sema smart00630
semaphorin domain;
34-456 8.82e-69

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 237.65  E-value: 8.82e-69
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681    34 FLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKlecPQAHHTDNHNKL-LLVNTVQKELIVC 112
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIrLLLDYNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   113 GS-VHQGICEKRSLESidhvlfrpespgdtqyvaandpnittvgliayskdevplLFVGRGYTSRGVGGGIPP-ITTRNL 190
Cdd:smart00630   78 GTnAFQPVCRLRNLGE---------------------------------------LYVGTVADFSGSDPAIPRsLSVRRL 118

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   191 RAHGGDVQATDSHSIFSYeetaklavgrlseYNHHFIKSFTYHSSVYFLFYRR--DLKSQSREYKTYISRICLDD----- 263
Cdd:smart00630  119 KGTSGVSLRTVLYDSKWL-------------NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggpr 185

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   264 ---SHYYSYVELPLLCQSKANT---YSLLQAAYVTRPGKElaqgqldtEGEVLFAAFSAWQASSGKlseeSALCVYTMEE 337
Cdd:smart00630  186 sldKKWTSFLKARLECSVPGEDpfyFNELQAAFLLPPGSE--------SDDVLYGVFSTSSNPIPG----SAVCAFSLSD 253

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   338 VDRLTNWTRDVCYMRDGKSEEGTEvAYIEYDVSSNCVQLPADTLyAYPC----GSDHTPSPMASRVPLEAAPLLEKT--E 411
Cdd:smart00630  254 INAVFNGPFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSK-DLPDetlnFIKSHPLMDEVVQPLTGRPLFVKTdsN 331

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1756842681   412 ARLTAVAVNVED---GHTIAFLGDSRGRLHKVYL---GAQGEAHTYASVSI 456
Cdd:smart00630  332 YLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLsesSSSSESVVLEEISV 382
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 24-526 1.60e-68

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 241.37  E-value: 1.60e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   24 YVTF--SHNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHH-TDNHNKLL 100
Cdd:cd11272      1 FNTFhsENRDWTFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVLTlTNNVNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  101 LVNTVQKELIVCGSVHQGICEKRSLESIdHVLFRPeSPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGytsrgVGG 180
Cdd:cd11272     81 IIDYSENRLLACGSLYQGVCKLLRLDDL-FILVEP-SHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTA-----VDG 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  181 G---IPPITTRNLRahggdvQATDSHSIFSYEETAKL----------AVGRLSEYNHHFIKSFTYHSSVYFLFYRRDL-- 245
Cdd:cd11272    154 KqdyFPTLSSRKLP------RDPESSAMLDYELHSDFvsslikipsdTLALVSHFDIFYIYGFASGNFVYFLTVQPETpe 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  246 -----KSQSREYKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQA 319
Cdd:cd11272    228 gvsinSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCVRGGVEYRLLQAAYLSKPGEVLARSlNITAQEDVLFAIFSKGQK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  320 SSGKLSEESALCVYTMEEVDRLTNWTRDVCYMRDGKSEEGTevaYIEYDVSSNCVQLPADTLYaypCGSDhTPSPMASRV 399
Cdd:cd11272    308 QYHHPPDDSALCAFPIRAINAQIKERLQSCYQGEGNLELNW---LLGKDVQCTKAPVPIDDNF---CGLD-INQPLGGST 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  400 PLEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYlgAQGEAH---TYASVSI-QVNSMVSGDLLFDQLQEHL 475
Cdd:cd11272    381 PVEGVTLYTSSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIR--ADGPPHggvQYEMVSVfKDGSPILRDMAFSIDHKYL 458

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1756842681  476 FVMTQSMVVKVPIMECSLYLDCESCLAVKDPYCGWCVLQGRCSRRSECLRS 526
Cdd:cd11272    459 YVMSERQVSRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRA 509
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
 24-488 6.93e-62

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 220.47  E-value: 6.93e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   24 YVTFS--HNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLL 100
Cdd:cd11244      1 FVTFRgePRDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPlTTTNNVNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  101 LVNTVQKELIVCGSVHQGICEKRSLESidhvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGV 178
Cdd:cd11244     81 LIDYSENRLIACGSLYQGVCKLLRLED----LFKLGEPHHKKehYLSGVNESGTMFGVIVSYSNGDDKLFIGTAVD--GK 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  179 GGGIPPITTRNLRAHggdvqaTDSHSIFSYE-------ETAKLAVGRLSEYNH---HFIKSFTYHSSVYFLFYRRDLKSQ 248
Cdd:cd11244    155 SEYFPTLSSRKLTAD------EESDGMFAYVyhdefvsSQIKIPSDTLSIIPDfdiYYVYGFSSGNFVYFLTLQPETQLT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  249 SRE------YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASS 321
Cdd:cd11244    229 PGDstgeqfYTSKIVRLCKDDTKFYSYVEFPIGCTRDGVEYRLLQAAYLSKPGKALAQAlGISEDEDVLFTIFSKGQKNR 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  322 GKLSEESALCVYTMEEVDRLTNWTRDVCYMRDGKseegTEVAYI-EYDVSSNCVQLPADTLYaypCGSDHTpSPMASRVP 400
Cdd:cd11244    309 MKPPDESALCLFTLKQINLRIKERLQSCYRGEGK----LSLPWLlNKDLPCINAPLQIDDNF---CGLDMN-QPLGGSDM 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  401 LEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMT 479
Cdd:cd11244    381 VEGIPLFTDDRDRMTSVAAYVYKGHSVVFVGTKSGKLKKIRVdGPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMS 460


                   ....*....
gi 1756842681  480 QSMVVKVPI 488
Cdd:cd11244    461 ERQVTRVPV 469
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
 1798-1916 3.86e-57

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 193.18  E-value: 3.86e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1798 LNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPYCHRPDPDTLDLEWRSG 1877
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEG------EVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHG 74

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1756842681 1878 LAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVAL 1916
Cdd:pfam20170   75 RGGRLILQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
 26-488 3.89e-56

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 203.66  E-value: 3.89e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   26 TFSHNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLLLVNT 104
Cdd:cd11271      6 TFTASDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGlGTTNNVNKLLLVDY 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  105 VQKELIVCGSVHQGICEKRSLESidhvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGVGGGI 182
Cdd:cd11271     86 AANRLIACGSASQGICQFLRLDD----LFKLGEPHHRKehYLSSVNESGTMSGVIIEVGNGQNKLFVGTPID--GKSEYF 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  183 PPITTRNLRAHGGDVQATDshsiFSYEE---TAKLAV-----GRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSRE--- 251
Cdd:cd11271    160 PTLSSRKLMANEENAEMFG----FVYQDefvSSQLKIpsdtlSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTSPDstg 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  252 ---YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGE-VLFAAFSAWQASSGKLSEE 327
Cdd:cd11271    236 eqfFTSKIVRLCVDDPKFYSYVEFPIGCEQDGVEYRLIQDAYLSKPGKALAKQLGISEREdILFTVFSQGQKNRVKPPKE 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  328 SALCVYTMEEVDRLTNWTRDVCYMRDGKseegTEVAYIeYDVSSNCVQLPADTLYAYpCGSDHTpSPMASRVPLEAAPLL 407
Cdd:cd11271    316 SVLCLFTLKKIKDKIKERIQSCYRGEGK----LSLPWL-LNKELGCINSPLQIDDNF-CGQDFN-QPLGGTVTIEGTPLF 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  408 EKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGE----AHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMV 483
Cdd:cd11271    389 VDKEDGMTSVAAYDYRGRTVVFAGTRSGRIKKILVDLSAPssrpALQYENVVAHEGSPILRDLVLSPDRQYIYAMTEKQV 468


                   ....*
gi 1756842681  484 VKVPI 488
Cdd:cd11271    469 TRVPV 473
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
 26-488 3.21e-55

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 200.93  E-value: 3.21e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   26 TFSHNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLLLVNT 104
Cdd:cd11273      5 AFVVTDTTLTHLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRlAPVDNVNKLLLVDY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  105 VQKELIVCGSVHQGICEKRSLESIDHvLFRPESPGDTQYVAANDPNiTTVGLIAYSKDEVPLLFVGRGytsrgVGGG--- 181
Cdd:cd11273     85 AGNRLVACGSIWQGVCQFLRLEDLFK-LGEPHHRKEHYLSGAQEPD-SMAGVIVEQGKGPSKLFVGTA-----IDGKsey 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  182 IPPITTRNLRAhggDVQATDSHSIFSYEE----TAKLAVGRLSEY---NHHFIKSFTYHSSVYFLFYRRDLK------SQ 248
Cdd:cd11273    158 FPTLSSRKLIS---DEDSADMFSLVYQDEfvssQIKIPSDTLSLYpafDIYYVYGFVSASFVYFLTLQLDTQqtlldtAG 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  249 SREYKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGE-VLFAAFSAWQASSGKLSEE 327
Cdd:cd11273    235 EKFFTSKIVRMCANDTEFYSYVEFPLGCSKDGVEYRLVQAAHLAKPGLLLAQALGVPEDEdVLFTIFSQGQKNRASPPRE 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  328 SALCVYTMEEVDRLTNWTRDVCYMRDGKseegtevayieydvssncVQLPADTLYAYPCgsDHTP-------------SP 394
Cdd:cd11273    315 TILCLFTLSNINAHIRERIQSCYRGEGT------------------LSLPWLLNKELPC--INTPmqingnfcglvlnQP 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  395 MASRVPLEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEH 474
Cdd:cd11273    375 LGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDMVFSPDHRY 454

                          490
                   ....*....|....
gi 1756842681  475 LFVMTQSMVVKVPI 488
Cdd:cd11273    455 IYLLSEKQVSQLPV 468
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 24-492 4.38e-55

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 200.56  E-value: 4.38e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   24 YVTF--SHNATKFLHLSMDLESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLEC-PQAHHTDNHNKLL 100
Cdd:cd11274      1 FITFtgDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCnEPLTLTNNINKML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  101 LVNTVQKELIVCGSVHQGICEKRSLESidhvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGV 178
Cdd:cd11274     81 LIDYKENRLIACGSLYQGICKLLRLDD----LFKLGEPFHKKehYLSGVNESGSVFGVIVSYSNLDDKLFIATAVD--GK 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  179 GGGIPPITTRNLrahggdVQATDSHSIFSY----EETAKL------AVGRLSEYNHHFIKSFTYHSSVYFLFYRRDL--- 245
Cdd:cd11274    155 PEYFPTISSRKL------TKNSEADGMFAYvfhdEFVASMikipsdTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMisp 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  246 -KSQSRE--YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASS 321
Cdd:cd11274    229 pGSTTKEqvYTSKLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSlGVGPDDDILFTVFSKGQKRK 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  322 GKLSEESALCVYTMEEVDRLTNWTRDVCYmrdgKSEEGTEVAYIEY-DVSSNCVQLPADTLYaypCGSDHTpSPMASRVP 400
Cdd:cd11274    309 MKSLDESALCIFVLKEINDRIKDRLQSCY----RGEGTLDLAWLKVkDIPCSSALLTIDDNF---CGLDMN-APLGVSEM 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  401 LEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMT 479
Cdd:cd11274    381 VRGLPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVdGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMS 460

                          490
                   ....*....|...
gi 1756842681  480 QSMVVKVPIMECS 492
Cdd:cd11274    461 EKQLTRVPVESCG 473
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 38-486 5.53e-40

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 156.55  E-value: 5.53e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   38 SMDLESGTVYLGATNFLFQLT-SDLLLENMVQTGPVLDSKDCLPPvsklECPQA--HH----TDNHNKLLLVNTVQKELI 110
Cdd:cd11247     15 ALDGGRGRLYLAAVNRLYQLSgLVLALEAEAAVGPVLDSPLCHAP----QLPQAtcEHprtlTDNYNKILQPDPEQGVLV 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  111 VCGSVHQGICEKRSLESIDHVLFRPESPGDTQY-----VAANDPNITTVGLIAYSKDEV--PLLFVGRGYTSRGVGG--- 180
Cdd:cd11247     91 VCGSIYQGLCQLRRLYNISAVAVRFPVDGDTVFpsmlnVAANHPNASTVGLVLWPRGGGggLRLLVGATYTGYGSGFfpr 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  181 ----------GIPPITTRNLRAHGG-------DVQATDShSIFSYEETAKlAVGRLS---EYNHHFIKSFTYhssvyfLF 240
Cdd:cd11247    171 nrsledhrfeNTPEIAIRALNTRGDlaklftfDINPSDD-NIFKIKQGAK-ARHKLSfvrAFLQHFLQPYAY------LA 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  241 YRRDLKSQSREYK--TYISRICLDDSH----------YYSYVELPLLCqskANTYSLLQAAYVTRPGKELaqgqldtege 308
Cdd:cd11247    243 MNGEANAAGKESQppSLLARICLPGRAppppgeakklTESYIQLGLRC---EGAYTRLVSVFPARVEEEQ---------- 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  309 vLFAAFSAWQASsgklseESALCVYTMEEVDRLTNWTRDVCYMrdgkSEEGTEVAYIEYDVSS--------NCVQLPADT 380
Cdd:cd11247    310 -LFAVFERAGGA------PAALCAFRFAEVEEPIRAARTACFV----SPAAGVVTVLDSVVQGtgpacerkLNIQLQPEQ 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  381 LyayPCGSDHTPSPMASRVPLEAAPLLekTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNS 460
Cdd:cd11247    379 L---DCGAAHLQHPLAILQPLKATPVF--RAPGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGE 453

                          490       500
                   ....*....|....*....|....*....
gi 1756842681  461 MVSGDLLFDQLQE-HLFVMT--QSMVVKV 486
Cdd:cd11247    454 PVHHVMQFDPSDStYLYLMTshQMTRVKV 482
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
 43-488 1.44e-31

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 131.00  E-value: 1.44e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   43 SGTVYLGATNFLFQLTSDLLLENMVQTGPVLdSKDCLPPVSKleCPQAHH---TDNHNKLLLVNTVQ-KELIVCGSVHQG 118
Cdd:cd11248     19 STEVYVAAQNVIYALNPDLQKVWEYKTGPVG-SPDCQTCQDC--SSGADPgvpKDTDNMVLVLETYYdDYLYSCGSTQNG 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  119 ICEKRSLE------SIDHVLFRPE---SPGDTQYVAAndPNITTVGLIaySKDEVPLLFVGRGYTSRgVGGGIPP--ITT 187
Cdd:cd11248     96 VCYRHVLEdgadiqSEVHCLFSKKnnsPSYCPDCVAS--PLGTKVTNV--ESGRTIYFFVANSVNSS-LAGSFPPhsISV 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  188 RNLRAHGGDVqatdsHSIFSYeetAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQ-SREYKTYISRICLDDSHY 266
Cdd:cd11248    171 RRLKEDGFGF-----LSDQSY---LDVLPSLRDSYPIKYVYSFHSGPFVYFLTVQRESLTKpSSAFHTRLVRLCSSDSEI 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  267 YSYVELPLLC--------QSKANT--YSLLQAAYVTRPGKELA-QGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTM 335
Cdd:cd11248    243 WRYREMPLECiftpkrrrRSTEEDvvYNVLQAAHVSKVGADLAdELGASEGDDILFGVFARSKPDSGEPMPNSALCAFPI 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  336 EEVDRLTNWTRDVCYMRDGKSEEGtevayieydvsSNCVQLPADTL--YAYPCGS--DHTPSPMAS---RVPLEAAPLle 408
Cdd:cd11248    323 KYVNDAIEKGVEKCCTSGLEHFSG-----------SLCHFQPCPTCpgESSSCEAtcKEYRTEVTKpyqRVDLFNGQM-- 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  409 kTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQG-EAHT-YASVSIQVNSMVS-----GDLLFdqlqehlfvMTQS 481
Cdd:cd11248    390 -SNVLLTSILVTTIGNHTVAHLGTSDGRVLQVVLSRSGpIPHVnFSLDSQPVSREVAvlssnGSLLF---------VTGD 459


                   ....*..
gi 1756842681  482 MVVKVPI 488
Cdd:cd11248    460 KITKVPL 466
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1135-1226 4.87e-28

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 109.33  E-value: 4.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1135 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIAETVTVAGIPCAVDAQEYEISSSIVCVTGGSWTERFGHiVVEVPGGG 1214
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNG-PVEVTVGH 79

                           90
                   ....*....|....*
gi 1756842681 1215 ---RGVSGHVFTYQN 1226
Cdd:cd01180     80 gsfRTESSEGFSFVD 94
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
 41-488 5.56e-28

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 120.36  E-value: 5.56e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   41 LESGTVYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPP---VSKLECPQAHHTDNHNKLLLVNTV-QKELIVCGSVH 116
Cdd:cd11278     33 LHKHHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFPCqdcSDKANLSNGVWKDNVNMALFVETYyDDQLISCGSVN 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  117 QGICEKRSL--------ESIDHVLFRPESPGDtqyvAANDPN--ITTVG--LIAYSKDEVPLLFVGRGYTsrgvGGGIPP 184
Cdd:cd11278    113 RGTCQRHVFphdhpadiQSEVHCIYSPQIEEE----PDQCPDcvVSTLGskVLVTVKDRFVNFFVGNTIN----SSYFPD 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  185 -----ITTRNLR-AHGGDVQATDShsifSYEETakLAVGRLSeYNHHFIKSFTYHSSVYFLFYRRD-LKSQSreYKTYIS 257
Cdd:cd11278    185 hplhsISVRRLKeTQDGFEFLTDQ----SYIDV--LPEFRDS-YPIKYVHAFESNNFVYFLTVQREsLDSQT--FHTRII 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  258 RICLDDSHYYSYVELPLLC---------QSKANTYSLLQAAYVTRPGKELAQGQ-LDTEGEVLFAAFSAWQASSGKLSEE 327
Cdd:cd11278    256 RFCSIDSELRSYMEMPLECiftekrrkrSTKKEVFNILQAAYVSKPGAQLAREMgASLNDDILFGVFAQSKPDSAEPMNR 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  328 SALCVYTMEEVDRLTNWTRDVCYMRDGKSEEGTEVAY-IEYDVSSNcvqlpadtlyAYPCGSDHTPSPMASRVPLEAAPL 406
Cdd:cd11278    336 SAVCAVSIKTINEFFNKIVDKQNVKCLQHFYGKNHEHcFNRTFLRN----------ASYCEARRDEYRVEVTTALQRVDL 405

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  407 L--EKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEahTYASVSIQVNSM-VSGDLLFDQLQE---HLFVMTQ 480
Cdd:cd11278    406 FmgQFSNVLLTSISVFTKGDLTIANLGTSEGRFMQVVVSRSGP--STPHVNFLLDSHpVSPEVIVEHTLNqngYTLVITG 483


                   ....*...
gi 1756842681  481 SMVVKVPI 488
Cdd:cd11278    484 KKITKIPL 491
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 549-636 1.11e-26

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.43  E-value: 1.11e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  549 TPANISREEKRNIFLAISDLPSLreEEFYSCYFEDY-ESPAVLTESGIMCPSPDPSQAPALPTGTDHVTIKLVVRF--HD 625
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTG 78

                           90
                   ....*....|.
gi 1756842681  626 IFIASVDFSFY 636
Cdd:pfam17960   79 VDFASTNFTFY 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 286-469 1.70e-25

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 105.43  E-value: 1.70e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  286 LQAAYVTRPGKELAQGqldtegEVLFAAFSAWQASSgklSEESALCVYTMEEVDRLTNwTRDVCYMRDGkSEEGTEVAYI 365
Cdd:pfam01403    1 LQDVFVLKPGAGDALD------TVLYGVFTTQWSNS---IGGSAVCAFSLSDINAVFE-GPFKEQEKSD-SKWLPYTGKV 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  366 EYDVSSNCV------QLPADTLyaypCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVN---VEDG-HTIAFLGDSRG 435
Cdd:pfam01403   70 PYPRPGTCIndplrlDLPDSVL----NFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDrvqALDGnYTVLFLGTDDG 145

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1756842681  436 RLHKVYLGAQGEAHTYASVSI-QVNSMVSGDLLFD 469
Cdd:pfam01403  146 RLHKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 988-1087 8.57e-23

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 94.65  E-value: 8.57e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  988 GSSLFPVNVARKITLLGKNFHLYQDQQWDYECVLNLEGRTVVMEAYVEGEETnkslcyITCQMNQYSYTAPQLEFNAVVF 1067
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDS------ITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 1756842681 1068 VQRRRHLRVDSAADLHVTFY 1087
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1317-1439 5.48e-20

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 86.70  E-value: 5.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1317 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVspserrrrgvgrwrrivpdsecpegslcsIQQFEEPCLVNSS 1396
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKY-----------------------------GGVEKTSCKVRNS 51

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1756842681 1397 YLILCKTPAINLLLRS---VRIKLEFILDNLSF-DFNSLHPMPFSYE 1439
Cdd:cd01181     52 TLMTCPAPSLALLNRSpepGERPVEFGLDGDNVqSLLILNRTSFSYY 98
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1227-1314 3.57e-17

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 78.03  E-value: 3.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1227 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLLGDLPCKILSEmTEDQLACQTSPSNVSTELPVTIKYGeQERRL 1306
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAG--SSVRVTVGGQPCKILSV-SSSQIVCLTPPSASPGEAPVKVLID-GARRL 76


                   ....*...
gi 1756842681 1307 EGSLFRYT 1314
Cdd:cd01179     77 APLVFTYT 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1135-1225 1.34e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.03  E-value: 1.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1135 PLIHSVYPLSGPVEGGTRITITGSNLGQkhQDIAETVTVAGIPCAVdaqEYEISSSIVCVTGGSWTERFGHIVVEV---P 1211
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGS--GSPRVRVTVGGVPCKV---LNVSSTEIVCRTPAAATPGEGPVEVTVdgaN 75

                           90
                   ....*....|....
gi 1756842681 1212 GGGRGVSGHVFTYQ 1225
Cdd:cd00603     76 VSARVLSNTTFTYV 89
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 42-488 3.39e-15

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 80.98  E-value: 3.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   42 ESGTVYLGATNFLFQLTSDL-LLENMVqTGPVlDSKDClppVSKLECPQAHH----TDNHNKLLLVNTVQKELIVCGSVH 116
Cdd:cd11279     37 DASAVFVATRNHLHVLNPELkLLQNLV-TGPT-GSPGC---QICALCPPGPPgpspEDTDNKVLVLDPEEPWLYSCGSSL 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  117 QGICEKRSLE---SIDHV-----LFRPE--SPGD-TQYVAAndPNITTVGLIAYSKdeVPLLFVGRGYTSRgVGGGIPP- 184
Cdd:cd11279    112 HGRCFLHELEsrgSAVHIastacLFSANanKPSDcPDCVAS--PLGTRVTVVEQSH--TSYFYVASTLNSS-VAASYSPr 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  185 -ITTRNLRahgGDVQATDS--HSIFSYEEtaklavgRLSEYNHHFIKSFTYHSSVYFLFYRRDlKSQSREYKTYISRICL 261
Cdd:cd11279    187 sVSIRRLK---SDQDGFAPgfHSLTVLPK-------YLDSYPIHYVHSFTSGDFVYFLTVQPE-SPDSSAYHTRLVRLSA 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  262 DDSHYYSYVELPLLCQ------------SKANTYSLLQAAYVTRPGKELAqGQLDTEG--EVLFAAFSAWQASSGKLSEE 327
Cdd:cd11279    256 KEPELRDYRELVLDCRfepkrrrrrrpaEREVPYNVLQAAHAAPVGSKLA-VELGISEgqEVLFGVFAESQPGSPVPQKN 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  328 SALCVYTMEEVDRLTNWTRDVCYmrDGKSEEGTEVAYIEYDVSSNCVQLPAdtlyaypcGSDHTPSPMASRVPLEAAPLL 407
Cdd:cd11279    335 SAVCAFPISLLNEAIDEGMEKCC--SSSNSDRLFRGLDFFQPQSYCPHPPN--------LSAAVSNTSCWNFPTLVSTSS 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  408 EKTE--------ARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYAS-VSIQVNSMVSGDllFDQLQEHLFVM 478
Cdd:cd11279    405 FRVDlfnghlsgVLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNYLLYVSnFSLGDGQPVQRD--VSRLGDSLLFA 482

                          490
                   ....*....|
gi 1756842681  479 TQSMVVKVPI 488
Cdd:cd11279    483 SGNQVFKVNI 492
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1135-1224 5.28e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 69.01  E-value: 5.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1135 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIaeTVTVAGIPCAVDAQeyeISSSIVCVTGGSWTERFGhIVVEVPGGG 1214
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISV---SSTTIVCTTPPGTSGLVN-VSVTVGGGG 74

                           90
                   ....*....|
gi 1756842681 1215 RGVSGHVFTY 1224
Cdd:pfam01833   75 ISSSPLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 491-540 3.38e-13

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 65.81  E-value: 3.38e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1756842681  491 CSLYLDCESCLAVKDPYCGWCVLQGRCSRRSECLRSRlSEQWLWSFNSTQ 540
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSK 50
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1135-1224 5.24e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 66.33  E-value: 5.24e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1135 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIaeTVTV-AGIPCAVdaqEYEISSSIVCVTGGSWTERFG--HIVVEVP 1211
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFG-SGSNL--RVTFgGGVPCSV---LSVSSTAIVCTTPPYANPGPGpvEVTVDRG 74

                           90
                   ....*....|...
gi 1756842681 1212 GGGRGVSGHVFTY 1224
Cdd:cd00102     75 NGGITSSPLTFTY 87
IPT smart00429
ig-like, plexins, transcription factors;
1135-1224 8.51e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 65.90  E-value: 8.51e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1135 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIAETVTVAGIPCAVDAQEyeiSSSIVCVTGGSWTERFGHIVVEVPGGG 1214
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77

                            90
                    ....*....|..
gi 1756842681  1215 RGVSG--HVFTY 1224
Cdd:smart00429   78 GGVPSspQPFTY 89
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
 32-487 1.30e-12

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 72.44  E-value: 1.30e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681   32 TKFLHLSMDLESGTVYLGATN--FLFQLTSDL-LLENMVQTGPvlDSKD-C-LPPVSKLECpqahhtDNHNKLLLVNTvQ 106
Cdd:cd11235      1 LKYHTKLLHEDRSTLYVGARDrvYLVDLDSLYtEQKVAWPSSP--DDVDtCyLKGKSKDDC------RNFIKVLEKNS-D 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  107 KELIVCGS-VHQGICEKRSLESIDHVlfrpESPGDTQYVAANDPNITTVGLiaYSKDEvplLFVGrgyTSRGVGGGIPPI 185
Cdd:cd11235     72 DSLLVCGTnAFNPSCRNYNVETFELV----GKEESGRGKCPYDPDHNSTAL--FADGE---LYSG---TSADFLGTDPVI 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  186 TtRNLRAHGGdvQATDSHSIFSYEETaklavgrlseynhHFIKSFTYHSSVYFlFYRRDlksqSREYKTY-------ISR 258
Cdd:cd11235    140 Y-RTLGHNPP--LRTEYHDSKWLNEP-------------QFVGAFDIGDYVYF-FFREI----AVEYINCgkavysrVAR 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  259 ICLDD--------SHYYSYVELPLLCQSKANT---YSLLQAAYVTrPGKELAQGqldtegeVLFAAFS-AWQASSGklse 326
Cdd:cd11235    199 VCKNDqggsrsleKKWTTFLKARLNCSVPGEFpfyFNELQDVFDL-PSPSNKEK-------IFYAVFTtPYNSIPG---- 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  327 eSALCVYTMEEVDR------------LTNWTRDVCYMRDGKSEEGTevayieYDVSSNcvqLPADTLyayPCGSDHTpsP 394
Cdd:cd11235    267 -SAVCAYSLSDIEAvfngpfkeqhssNSAWLPVPDERVPEPRPGTC------VDDSSP---LPDDTL---NFIKSHP--L 331

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  395 MASRV-PLEAAPLLEKTEA--RLTAVAVNVEDG-----HTIAFLGDSRGRLHKVYlgAQGEAHTYASVSIQV------NS 460
Cdd:cd11235    332 MDEAVtPILNRPLFIKTDVnyRFTKIAVDRVQAklgqtYDVLFVGTDRGIILKVV--SLPEQGLQASNILEEmpvgppPE 409

                          490       500
                   ....*....|....*....|....*..
gi 1756842681  461 MVSGdLLFDQLQEHLFVMTQSMVVKVP 487
Cdd:cd11235    410 PIQT-MQLSRKRRSLYVGSETGVLQVP 435
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
490-527 9.17e-12

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 61.41  E-value: 9.17e-12
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1756842681   490 ECSLYLDCESCLAVKDPYCGWCVLQGRCSRRSECLRSR 527
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRR 38
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1227-1314 5.29e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 60.93  E-value: 5.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1227 PELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNeISVLLGDLPCKILSEmTEDQLACQTSPSNVSTELPVTIKYGE---QE 1303
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPR-VRVTVGGVPCKVLNV-SSTEIVCRTPAAATPGEGPVEVTVDGanvSA 78

                           90
                   ....*....|.
gi 1756842681 1304 RRLEGSLFRYT 1314
Cdd:cd00603     79 RVLSNTTFTYV 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-905 7.27e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 7.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  688 IPISIVHPSSAAPLTKSSTAAPTMATKPVTtPVHVGPSTVPHTEAIHVTPSAAWEATTEPAqsPSYTRLSLPTEGASLQA 767
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPAT-PGGPARPARPPTTAGPPAPAPPAAPAAGPP--RRLTRPAVASLSESRES 2797

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  768 ATEAPLPPPADNPV-----TVPETTSPAAPVFSSPSknmdhiALPTeGPATAQEArhTDPPTTLGGS----------PLH 832
Cdd:PHA03247  2798 LPSPWDPADPPAAVlapaaALPPAASPAGPLPPPTS------AQPT-APPPPPGP--PPPSLPLGGSvapggdvrrrPPS 2868

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1756842681  833 TSPVAAVTLSPHVTSFKWP-PSPFPTTEALTSAISSPQTPSQvPGSPvvsdddTPGSPGTELPVSGLPTSAPPQ 905
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLArPAVSRSTESFALPPDQPERPPQ-PQAP------PPPQPQPQPPPPPQPQPPPPP 2935
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 689-1001 8.36e-11

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 66.91  E-value: 8.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  689 PISIVHPSSAAPLTKSSTAAPTMA-TKPVT----TPVHVGPST-VPHTEAIHV-TPSAAWEATTEPAQSPSYTRLSLPTE 761
Cdd:pfam17823  118 AASSSPSSAAQSLPAAIAALPSEAfSAPRAaacrANASAAPRAaIAAASAPHAaSPAPRTAASSTTAASSTTAASSAPTT 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  762 GASLQAATEAPLPP---PADNPVTVPETTSPAAPVFSSPSKNMDHIALPTEGPAT-AQEARHTDPPTTLGGSPLHTSPVA 837
Cdd:pfam17823  198 AASSAPATLTPARGistAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAAlATLAAAAGTVASAAGTINMGDPHA 277

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  838 AvTLSP--HVTSFKWPPSPFPT----TEALTSAISSPQTPSQVPGSPVVSDDDTPGSPGTelPVSGLPTSAPPQWLTELQ 911
Cdd:pfam17823  278 R-RLSPakHMPSDTMARNPAAPmgaqAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNT--PKSVASTNLAVVTTTKAQ 354

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  912 DTEDwmdllqaendtslfSASTllsgdgdsserdVPDFPRILHPDLdyqydapefweESEEPSWGPNACPCVQGIQGSS- 990
Cdd:pfam17823  355 AKEP--------------SASP------------VPVLHTSMIPEV-----------EATSPTTQPSPLLPTQGAAGPGi 397

                          330
                   ....*....|..
gi 1756842681  991 -LFPVNVARKIT 1001
Cdd:pfam17823  398 lLAPEQVATEAT 409
PHA03247 PHA03247
large tegument protein UL36; Provisional
 686-956 2.24e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 2.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  686 AQIPISIVHPSSAAPLTKSSTAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPtegaSL 765
Cdd:PHA03247  2816 AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP----AV 2891

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  766 QAATEA-PLPPPADNPVTVPETTSPAAPVFSSPSKNMDHIALPTEGPATAQEARHTDPPTTLGGSPLHTSPV--AAVTLS 842
Cdd:PHA03247  2892 SRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWlgALVPGR 2971

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  843 PHVTSFKwPPSPFPTTEAltsAISSPQTPSQVPGSPVVS--------DDDTPGspgtelPVSGLPTSAPPqwltelQDTE 914
Cdd:PHA03247  2972 VAVPRFR-VPQPAPSREA---PASSTPPLTGHSLSRVSSwasslalhEETDPP------PVSLKQTLWPP------DDTE 3035

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1756842681  915 DwmdllqAENDTSLFSASTLLSGDGDSSERDVPDFPRILHPD 956
Cdd:PHA03247  3036 D------SDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPD 3071
PHA03247 PHA03247
large tegument protein UL36; Provisional
 683-984 5.69e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.34  E-value: 5.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  683 NERAQIPISIVHPSSAAPLTKSSTAAPTMATKPVTTPVHVGPST-VPHTEAIHVTPSAAWEATTEPAQSPSYTrlsLPTE 761
Cdd:PHA03247  2755 ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLpSPWDPADPPAAVLAPAAALPPAASPAGP---LPPP 2831

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  762 GASLQAA---TEAPLP------------------PPADNPVTVPeTTSPAAPVFS----SPSKNMDHIALPTEGPATAQE 816
Cdd:PHA03247  2832 TSAQPTApppPPGPPPpslplggsvapggdvrrrPPSRSPAAKP-AAPARPPVRRlarpAVSRSTESFALPPDQPERPPQ 2910

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  817 ARHTDPPTTLGGSPLHTSPVAAVTLSPHVTSfkwPPSPFPTTEAL---TSAISSPQTPSQVPGSPVVSDDDTPGS-PGTE 892
Cdd:PHA03247  2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP---PLAPTTDPAGAgepSGAVPQPWLGALVPGRVAVPRFRVPQPaPSRE 2987

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  893 LPVS------GLPTSAPPQWLTELQDTEDW----MDLLQA---ENDTSLFSASTLLSGDGDSSERDVPDfprilhPDLDY 959
Cdd:PHA03247  2988 APASstppltGHSLSRVSSWASSLALHEETdpppVSLKQTlwpPDDTEDSDADSLFDSDSERSDLEALD------PLPPE 3061

                          330       340
                   ....*....|....*....|....*
gi 1756842681  960 QYDAPEFWEESEEPSWGPNACPCVQ 984
Cdd:PHA03247  3062 PHDPFAHEPDPATPEAGARESPSSQ 3086
PHA03247 PHA03247
large tegument protein UL36; Provisional
 689-904 6.90e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 6.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  689 PISIVHPSSAAPLTKSSTAAPTMATKPVTTPvhvgPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGASLQAA 768
Cdd:PHA03247  2598 PRAPVDDRGDPRGPAPPSPLPPDTHAPDPPP----PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA 2673

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  769 TEAPLPP---------PADNPVT----------------------VPETTSPAAPVFSSPSKNMDHIALPT-EGPAT-AQ 815
Cdd:PHA03247  2674 AQASSPPqrprrraarPTVGSLTsladpppppptpepaphalvsaTPLPPGPAAARQASPALPAAPAPPAVpAGPATpGG 2753

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  816 EARHTDPPTTlGGSPLHTSPVAAVTLSPHVTSFKWPPSPFPTTEALTSAISSPQTPSQVPG-SPVVSDDDTPgSPGTELP 894
Cdd:PHA03247  2754 PARPARPPTT-AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLApAAALPPAASP-AGPLPPP 2831

                          250
                   ....*....|
gi 1756842681  895 VSGLPTSAPP 904
Cdd:PHA03247  2832 TSAQPTAPPP 2841
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 695-973 8.78e-10

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 64.40  E-value: 8.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  695 PSSAAPLTKSSTAAPTMATKPVTTP--------------VHVGPSTVPH---TEAIHVTPSAAWEATTEPAQS----PSY 753
Cdd:pfam03154  243 PSPHPPLQPMTQPPPPSQVSPQPLPqpslhgqmppmphsLQTGPSHMQHpvpPQPFPLTPQSSQSQVPPGPSPaapgQSQ 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  754 TRLSLPTEGASLQAAT---EAPLPP-PADNPVTVPETTSPAAPVFSSPS-KNMDHIAlpteGPATAQEARHTDPPTTL-- 826
Cdd:pfam03154  323 QRIHTPPSQSQLQSQQpprEQPLPPaPLSMPHIKPPPTTPIPQLPNPQShKHPPHLS----GPSPFQMNSNLPPPPALkp 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  827 -GGSPLHTSPVA---AVTLSPHVTSFKWPPSPFPtteALTSAISSPQTPSQVPG----------SPVVSDDDTPGSPGTE 892
Cdd:pfam03154  399 lSSLSTHHPPSAhppPLQLMPQSQQLPPPPAQPP---VLTQSQSLPPPAASHPPtsglhqvpsqSPFPQHPFVPGGPPPI 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  893 LPVSGLPTSAPPQwltelqdtedwMDLLQAENDTSLfsastllsgdgdSSERDVPDFPRILHPDLDYQYDAPEFWEESEE 972
Cdd:pfam03154  476 TPPSGPPTSTSSA-----------MPGIQPPSSASV------------SSSGPVPAAVSCPLPPVQIKEEALDEAEEPES 532


                   .
gi 1756842681  973 P 973
Cdd:pfam03154  533 P 533
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-904 1.59e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.80  E-value: 1.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  688 IPISIVHPSSAAPLTKSSTAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGASLQA 767
Cdd:PHA03247  2568 VPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP 2647

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  768 ATEAPLPPPADNPVTVP-ETTSPA-APVFSSPSKNMDHIAL-PTEGPATAQeARHTDPPTTLGGSPLHTSPVAAVTLSPH 844
Cdd:PHA03247  2648 PPERPRDDPAPGRVSRPrRARRLGrAAQASSPPQRPRRRAArPTVGSLTSL-ADPPPPPPTPEPAPHALVSATPLPPGPA 2726

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1756842681  845 VTSFKWPPSPF-PTTEALTSAISSPQTPSQVPGSPVVSDDDTPGSPGTelPVSGLPTSAPP 904
Cdd:PHA03247  2727 AARQASPALPAaPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA--PAAGPPRRLTR 2785
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1135-1224 3.92e-09

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 55.31  E-value: 3.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1135 PLIHSVYPLSGPVEGGTRITITGSNLgqkhqDIAET--VTVAGIPCAVDAQEyeiSSSIVCVTGGSWTERFGHIVVEVpG 1212
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHL-----NAGSSvrVTVGGQPCKILSVS---SSQIVCLTPPSASPGEAPVKVLI-D 71

                           90
                   ....*....|..
gi 1756842681 1213 GGRGVSGHVFTY 1224
Cdd:cd01179     72 GARRLAPLVFTY 83
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1227-1314 8.84e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 54.39  E-value: 8.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1227 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLL-GDLPCKILSEmTEDQLACQTSPSNVSTELPV--TIKYGEQE 1303
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSG--SNLRVTFgGGVPCSVLSV-SSTAIVCTTPPYANPGPGPVevTVDRGNGG 77

                           90
                   ....*....|.
gi 1756842681 1304 RRLEGSLFRYT 1314
Cdd:cd00102     78 ITSSPLTFTYV 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1227-1313 1.51e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.60  E-value: 1.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1227 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhPNEISVLLGDLPCKILSeMTEDQLACQTsPSNVSTELPVTIKYGEQERRL 1306
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTD-SSDLKVTIGGTPCTVIS-VSSTTIVCTT-PPGTSGLVNVSVTVGGGGISS 77


                   ....*..
gi 1756842681 1307 EGSLFRY 1313
Cdd:pfam01833   78 SPLTFTY 84
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1981-2086 1.71e-08

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 57.89  E-value: 1.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1981 EIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDEQAMHYGIADPETIHIWKTNSLPLRFWINIIKNPQ- 2059
Cdd:cd04519    115 LPVGEDLEENLENLLELVNKLVDRILSSLDRLPPELRYVFKILREFLAERFPEEPDEAYQAVSGFLFLRFICPAIVSPEl 194

                           90       100
                   ....*....|....*....|....*...
gi 1756842681 2060 -FVFDVQTSDNVDAVLLVIAQTFMDSCT 2086
Cdd:cd04519    195 fGLVPDEPSEQARRNLTLISKVLQSLAN 222
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 708-902 1.76e-08

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 59.59  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  708 APTMATKPVTTpvhvgpstVPHTEAIHVTPSaawEATTEpaQSPSYTRLSLPT--EGASLQAATEAPLPPPADNPVTVPE 785
Cdd:pfam17823   62 AATAAPAPVTL--------TKGTSAAHLNST---EVTAE--HTPHGTDLSEPAtrEGAADGAASRALAAAASSSPSSAAQ 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  786 TTSPAAPvfsspsknmdhiALPTEGPATaqearhtdPPTTLGGSPLHTSPVAAV--TLSPHVTSfkwpPSPfPTTEALTS 863
Cdd:pfam17823  129 SLPAAIA------------ALPSEAFSA--------PRAAACRANASAAPRAAIaaASAPHAAS----PAP-RTAASSTT 183

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1756842681  864 AISSPQTPSQVPGSPVVSdddtpgSPGTELPVSGLPTSA 902
Cdd:pfam17823  184 AASSTTAASSAPTTAASS------APATLTPARGISTAA 216
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
 236-488 2.49e-08

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 58.96  E-value: 2.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  236 VYFLFYRRdlksqSREYKTY-------ISRICLDD--------SHYYSYVELPLLCQSKANT--YSLLQAAYVTRPGkel 298
Cdd:cd11240    193 IYFFFTET-----AVEYDFYekvtvsrVARVCKGDlggqrtlqKKWTTFLKAQLVCSQPDSGlpFNVLRDVFVLSPD--- 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  299 aqgqlDTEGEVLFAAFSA-WQASSGklseeSALCVYTMEEVDRL------------TNWTR---DVCYMRDGKSeeGTEV 362
Cdd:cd11240    265 -----SWDATIFYGVFTSqWNVSGL-----SAVCAYSLEDIKKVfsgkykefnretSKWSRytgPVPDPRPGAC--ITNS 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  363 AYIEYDVSSncVQLPADTLYAYpcgSDHtpsP-MASRVPLEAAPLLEKTEARLTAVAVNVEDG-----HTIAFLGDSRGR 436
Cdd:cd11240    333 ARSQGITSS--LNLPDNVLTFV---KDH---PlMDEQVHPINRPLLVKSGVNYTRIAVHRVQAldgqtYTVLFLGTEDGF 404

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1756842681  437 LHKVYLGAqGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11240    405 LHKAVSLD-GGMHIIEEIQLFDQPQPVKNLLLSSSKGVLYVGSSSGVVQVPL 455
PHA03247 PHA03247
large tegument protein UL36; Provisional
 695-905 5.72e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 5.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  695 PSSAAPLTksSTAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGA-----SLQAAT 769
Cdd:PHA03247  2689 RPTVGSLT--SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArparpPTTAGP 2766

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  770 EAPLPPPAdnPVTVPETTSPAAPVFS-SPSKNMDHIALPTEGPATAQEARHTDPPTTLGGSPLHTSPVAAVTLSPHVtsf 848
Cdd:PHA03247  2767 PAPAPPAA--PAAGPPRRLTRPAVASlSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP--- 2841

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756842681  849 kwPPSPFPTTEALTSAIsspqtpsqVPGSPVV------SDDDTPGSPgTELPVSGLPTSAPPQ 905
Cdd:PHA03247  2842 --PPGPPPPSLPLGGSV--------APGGDVRrrppsrSPAAKPAAP-ARPPVRRLARPAVSR 2893
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
696-904 7.40e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 57.94  E-value: 7.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  696 SSAAPLTKSSTAAPTMATKPvtTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEgaslqAATEAPLPP 775
Cdd:PRK07003   393 ASAVPAVTAVTGAAGAALAP--KAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANAR-----ASADSRCDE 465

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  776 PADNPVTVPETTspAAPVFSSPSKNMDHIAlPTEGPATAQEARHTDPPTTLGGSPLHTSPVAAVTLSPHVTsfkwPPSPF 855
Cdd:PRK07003   466 RDAQPPADSGSA--SAPASDAPPDAAFEPA-PRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEAR----PPTPA 538

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1756842681  856 PTTEALTSAISSPQTPSQVPGSPVVSDDDTPGSPGTELPVSGLPTSAPP 904
Cdd:PRK07003   539 AAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKP 587
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 683-947 8.47e-08

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 57.62  E-value: 8.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  683 NERAQIPISIVHPSSaapLTKSSTAAPTMATKPVTTPVHVG---------PSTVPHTEAIH------VTPSAAWEATTEP 747
Cdd:pfam05109  443 NTTTGLPSSTHVPTN---LTAPASTGPTVSTADVTSPTPAGttsgaspvtPSPSPRDNGTEskapdmTSPTSAVTTPTPN 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  748 AQSPSyTRLSLPTEGASlqAATEAPLPPPADNPVTVPETTSPaAPVFSSPSKNMdhiALPTEGPATAQEARHTDPPTTLG 827
Cdd:pfam05109  520 ATSPT-PAVTTPTPNAT--SPTLGKTSPTSAVTTPTPNATSP-TPAVTTPTPNA---TIPTLGKTSPTSAVTTPTPNATS 592

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  828 GSPLHTSPVAAVT--------LSPHVTSfkwPPSpfPTTEALTSA---ISSPQT------PSQVPG--SPVVSDDDTPGS 888
Cdd:pfam05109  593 PTVGETSPQANTTnhtlggtsSTPVVTS---PPK--NATSAVTTGqhnITSSSTssmslrPSSISEtlSPSTSDNSTSHM 667

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1756842681  889 PgteLPVSGLPTSAppQWLTELQDTEDWMDLLQAENDTSLFSASTLLSGDGDSSERDVP 947
Cdd:pfam05109  668 P---LLTSAHPTGG--ENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKP 721
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 673-884 1.02e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 57.41  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  673 ATCEEGTIIYNERAQIPISIVHPSSAAPLTKSSTAAPTMATKPVTTPVHVGPST-------VPHTEAIHVTPsaaWEATT 745
Cdd:PRK08691   364 ASCDANAVIENTELQSPSAQTAEKETAAKKPQPRPEAETAQTPVQTASAAAMPSegktagpVSNQENNDVPP---WEDAP 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  746 EPAQSPSYTRlslPTEGASLQAATEAPLPPP--------ADNPVTVPETTSPA-APVFSSPSKNmdhialPTEGPATAQE 816
Cdd:PRK08691   441 DEAQTAAGTA---QTSAKSIQTASEAETPPEnqvsknkaADNETDAPLSEVPSeNPIQATPNDE------AVETETFAHE 511

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1756842681  817 ArhTDPPTTLGGSPLHTSPV---AAVTLSPHVTSFKWPPSPFPT-TEALTSAISSPQTPSQVPgsPVVSDDD 884
Cdd:PRK08691   512 A--PAEPFYGYGFPDNDCPPedgAEIPPPDWEHAAPADTAGGGAdEEAEAGGIGGNNTPSAPP--PEFSTEN 579
IPT smart00429
ig-like, plexins, transcription factors;
1226-1314 1.05e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 51.27  E-value: 1.05e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1226 NPELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNEISVLLGDLPCKILSEmTEDQLACQTSPSNVST-ELPV-TIKYGEQE 1303
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPS-SSTAIVCKTPPYHNIPgSVPVrTVGLRNGG 79

                            90
                    ....*....|.
gi 1756842681  1304 RRLEGSLFRYT 1314
Cdd:smart00429   80 VPSSPQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
1316-1438 1.06e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 51.27  E-value: 1.06e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1316 DPNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVSpserrrrgvgrwrrivpdsecpeGSLCSIQQfeepclvNS 1395
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVG-----------------------EAPCTFSP-------SS 50

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1756842681  1396 SYLILCKTPAINLLLRSVRI-KLEFILDNLSFDfnslhPMPFSY 1438
Cdd:smart00429   51 STAIVCKTPPYHNIPGSVPVrTVGLRNGGVPSS-----PQPFTY 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 689-904 1.11e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 1.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  689 PISIVHPSSAAPLTKSSTAAPTMATKPVTTPVH------------------------VGPSTVPHTEAIHVTPSAAWEAT 744
Cdd:PHA03247  2498 PGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHprmltwirgleelasddagdppppLPPAAPPAAPDRSVPPPRPAPRP 2577

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  745 TEPAQSPSYTRLSLPTEGASLQA---------ATEAPLPPPADNPVTVPETTSPaAPVFSSPSKNMDHIALPTEGPATAQ 815
Cdd:PHA03247  2578 SEPAVTSRARRPDAPPQSARPRApvddrgdprGPAPPSPLPPDTHAPDPPPPSP-SPAANEPDPHPPPTVPPPERPRDDP 2656

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  816 EARHTDPP---TTLGGSPLHTSP-------VAAVTLSPhVTSFKWPPSPFPTTE----ALTSAISSPQTPSQVPGS--PV 879
Cdd:PHA03247  2657 APGRVSRPrraRRLGRAAQASSPpqrprrrAARPTVGS-LTSLADPPPPPPTPEpaphALVSATPLPPGPAAARQAspAL 2735

                          250       260
                   ....*....|....*....|....*.
gi 1756842681  880 VSDDDTPGSP-GTELPVSGLPTSAPP 904
Cdd:PHA03247  2736 PAAPAPPAVPaGPATPGGPARPARPP 2761
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
698-915 1.47e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 56.81  E-value: 1.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  698 AAPltKSSTAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGASLQAATE----APL 773
Cdd:PRK12323   372 AGP--ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARgpggAPA 449

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  774 PPPADNPVTVPETTSPAAPVfsSPSKNMDHIALPTEGPATAQEARHTDPP---------TTLGGSPLHTSPVAAVTLSPH 844
Cdd:PRK12323   450 PAPAPAAAPAAAARPAAAGP--RPVAAAAAAAPARAAPAAAPAPADDDPPpweelppefASPAPAQPDAAPAGWVAESIP 527

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  845 VTSFKWPPSPFPT-----TEALTSAISSPQTPSQVPGSPVVSDDDTPGSPGTELPV--SGLPTSAPPQWL---TELQDTE 914
Cdd:PRK12323   528 DPATADPDDAFETlapapAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPAlaARLPVRGLAQQLarqSELAGVE 607


                   .
gi 1756842681  915 D 915
Cdd:PRK12323   608 G 608
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 693-915 1.52e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.10  E-value: 1.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  693 VHPSSAAPLTKSSTAAPTMATKPVttpvhvGPSTVPHTEAIHVTPSAAWEATTEPAQSPSyTRLSLPTEGASLQAATEAP 772
Cdd:PHA03307    42 QLVSDSAELAAVTVVAGAAACDRF------EPPTGPPPGPGTEAPANESRSTPTWSLSTL-APASPAREGSPTPPGPSSP 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  773 LPPPAdnpvtvpeTTSPAAPvfsSPSKNMDHIALPTEGPATAQEARHTDPPTTL----GGSPLHTSPVAAVTLS---PHV 845
Cdd:PHA03307   115 DPPPP--------TPPPASP---PPSPAPDLSEMLRPVGSPGPPPAASPPAAGAspaaVASDAASSRQAALPLSspeETA 183

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  846 TSFKWPPSPFPTTEALTSAISSPqtpsQVPGSPVVSDDDTPGSPGTELPVSGLPTSAPPQWLTELQDTED 915
Cdd:PHA03307   184 RAPSSPPAEPPPSTPPAAASPRP----PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGW 249
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 694-873 6.75e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.77  E-value: 6.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  694 HPSSAAPLTKSSTAAPTMATKPVTT-PVHVGPSTvpHTEAIHVTPSAAwEATTEPAQSPSYTR--------LSLPTEGAS 764
Cdd:pfam03154  377 HLSGPSPFQMNSNLPPPPALKPLSSlSTHHPPSA--HPPPLQLMPQSQ-QLPPPPAQPPVLTQsqslpppaASHPPTSGL 453

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  765 LQAATEAPLP---------PPADNPVTVPETTSPAAPVFSSPSKNMDHIALPTEGPATAqearhTDPPTTLGGSPLHTSP 835
Cdd:pfam03154  454 HQVPSQSPFPqhpfvpggpPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSC-----PLPPVQIKEEALDEAE 528

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1756842681  836 VAAVTLSPHVTsfkwpPSPFPTTealtsaISSPQTPSQ 873
Cdd:pfam03154  529 EPESPPPPPRS-----PSPEPTV------VNTPSHASQ 555
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
689-906 8.21e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.47  E-value: 8.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  689 PISIVHPSSAAPltksstAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGASLQAA 768
Cdd:PRK07003   406 AGAALAPKAAAA------AAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASA 479

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  769 TEAPLPPPADNpvtvpETTSPAAPVFSSPSKNMDHIALPT------EGPATAQEARHTDPPTTLGGSPLHTSPVAAVTLS 842
Cdd:PRK07003   480 PASDAPPDAAF-----EPAPRAAAPSAATPAAVPDARAPAaasredAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALD 554

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1756842681  843 P------HVTSFKW--------PPSPFPTTEalTSAISSPQTPSQVPGSPVVSDDDTPgSPGTELPVSGLPTSAPPQW 906
Cdd:PRK07003   555 VlrnagmRVSSDRGaraaaaakPAAAPAAAP--KPAAPRVAVQVPTPRARAATGDAPP-NGAARAEQAAESRGAPPPW 629
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 685-904 1.58e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.62  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  685 RAQIPIS----IVHPSSAAPLTKSSTAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWeATTEPAQSPSYtrLSLPT 760
Cdd:pfam03154  306 QSQVPPGpspaAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQL-PNPQSHKHPPH--LSGPS 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  761 egaSLQAATEAPlPPPADNPVTVPETTSPAA---PVFSSPSKNMDHIALPTEGPATAQEARH-----TDPPTTLGGSPLH 832
Cdd:pfam03154  383 ---PFQMNSNLP-PPPALKPLSSLSTHHPPSahpPPLQLMPQSQQLPPPPAQPPVLTQSQSLpppaaSHPPTSGLHQVPS 458

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  833 TSPVAAVTLSPHVTSFKWPPSPFPTTeaLTSAISSPQTPSQVPGSpvvSDDDTPGSPGTELPVSGL----------PTSA 902
Cdd:pfam03154  459 QSPFPQHPFVPGGPPPITPPSGPPTS--TSSAMPGIQPPSSASVS---SSGPVPAAVSCPLPPVQIkeealdeaeePESP 533


                   ..
gi 1756842681  903 PP 904
Cdd:pfam03154  534 PP 535
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 688-874 1.89e-06

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 53.01  E-value: 1.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  688 IPISivhPSSAAPLTKSSTAAPTMATkPVTTPVHVGPSTVPHTEAIHV--------TPSAAWEaTTEPAQSPSYTrlslP 759
Cdd:PLN03209   387 IPTP---PSSSPASSKSVDAVAKPAE-PDVVPSPGSASNVPEVEPAQVeakktrplSPYARYE-DLKPPTSPSPT----A 457

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  760 TEGASLQAATEAPLP----PPADNPVTVPETTSPAAPVFSSPSKNMDHIALPTEgPATAQEARHTDPPTTLGGSPLHTS- 834
Cdd:PLN03209   458 PTGVSPSVSSTSSVPavpdTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTS-PSPAAPVGKVAPSSTNEVVKVGNSa 536

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1756842681  835 -PVAAVTLSPHVTSFKWPPSPFPTTEALTSAiSSPqTPSQV 874
Cdd:PLN03209   537 pPTALADEQHHAQPKPRPLSPYTMYEDLKPP-TSP-TPSPV 575
PHA03378 PHA03378
EBNA-3B; Provisional
 686-890 2.72e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 52.76  E-value: 2.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  686 AQIPISIVHPS--SAAPLTKS---STAAP-------------TMATKPVTTPVHVGPStvPH-TEAIHVTP-SAAW-EAT 744
Cdd:PHA03378   593 AQTPWPVPHPSqtPEPPTTQShipETSAPrqwpmplrpipmrPLRMQPITFNVLVFPT--PHqPPQVEITPyKPTWtQIG 670

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  745 TEPAQ-SPSYTRLSLPTEGASLQAATEAPLPPPADNPVTVP-------ETTSPAAPVFSSPSKNMDHIALPTEGPATAQE 816
Cdd:PHA03378   671 HIPYQpSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPgraqrpaAATGRARPPAAAPGRARPPAAAPGRARPPAAA 750

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1756842681  817 ARHTDPPTtlgGSPLHTSPVAAVTLSPHVTSfkwPPSPFPTTEALTSAISSPQTPSQVPGSPV-VSDDDTPGSPG 890
Cdd:PHA03378   751 PGRARPPA---AAPGRARPPAAAPGAPTPQP---PPQAPPAPQQRPRGAPTPQPPPQAGPTSMqLMPRAAPGQQG 819
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 714-904 6.51e-06

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 51.08  E-value: 6.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  714 KPVTTPVHVGPSTVPhtEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGASLQAATEAPLPPPADNPVTVPETT-SPAAP 792
Cdd:PLN03209   381 KPPTSPIPTPPSSSP--ASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYEDLKPPTSpSPTAP 458

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  793 VFSSPSKNMDHIALPTEGPATAQEARHTDPPTTLGGSPLHTSPVAAVTLSPHVTSfkwPPSPFPTTEALTSAISSPQTPS 872
Cdd:PLN03209   459 TGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPS---PAAPVGKVAPSSTNEVVKVGNS 535

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1756842681  873 QVPGSPVVSDDDT-----PGSPGTELPVSGLPTSAPP 904
Cdd:PLN03209   536 APPTALADEQHHAqpkprPLSPYTMYEDLKPPTSPTP 572
PHA03378 PHA03378
EBNA-3B; Provisional
 661-904 1.28e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.45  E-value: 1.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  661 NWCIQQHLCTHKAT-CEEGTIIYNERAQIPISIVHPSSAAPLTKSSTAAPTMATKPVTTPVHVGPSTVPHTEAihVTPSA 739
Cdd:PHA03378   652 HQPPQVEITPYKPTwTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRA--RPPAA 729

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  740 AWEATTEPAQSPSYTRlslPTEGASLQAATEAPLPPPADNPVTVPETTSPAAPvfsspsknmdhialPTEGPATAQEARH 819
Cdd:PHA03378   730 APGRARPPAAAPGRAR---PPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPP--------------PQAPPAPQQRPRG 792

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  820 TDPPTtlggsPLHTSPVAAVTLSPHVTSFKWPPSPFPTTEALTSAISSPQTPSQVPG-----SPVVSDDDtPGSpGTELP 894
Cdd:PHA03378   793 APTPQ-----PPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAalerqAAAGPTPS-PGS-GTSDK 865

                          250
                   ....*....|
gi 1756842681  895 VSGLPTSAPP 904
Cdd:PHA03378   866 IVQAPVFYPP 875
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 761-940 1.99e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 49.71  E-value: 1.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  761 EGASLQAATEAPLPPPADNPVTVPETTSPAAPVFSSPSKNMdhIALPTEGPATAQEARHTDPPTTLGGSPLHTSPVAAvt 840
Cdd:PRK14951   370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAA--ASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAV-- 445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  841 lsphvtsfkwPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDDTPGSPGTELPvsglPTSAPPQWLTelqdteDWMDLL 920
Cdd:PRK14951   446 ----------ALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLT----PTEEGDVWHA------TVQQLA 505

                          170       180
                   ....*....|....*....|....
gi 1756842681  921 QAENDTSLFS----ASTLLSGDGD 940
Cdd:PRK14951   506 AAEAITALARelalQSELVARDGD 529
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
 225-488 4.09e-05

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 48.67  E-value: 4.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  225 HFIKSFTYHSSVYFLFyrRDLksqSREYKTY-------ISRICLDD---------SHYYSYVELPLLCQSKANT---YSL 285
Cdd:cd11242    174 HFVHAVEYGDYVYFFF--REI---AVEYNTLgkvvfsrVARVCKNDmggsprvleKQWTSFLKARLNCSVPGDShfyFDV 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  286 LQAayVTRPgkelaqgqLDTEG-EVLFAAFSAwQASSgklSEESALCVYTMEEVDRLTN------------WT------- 345
Cdd:cd11242    249 LQA--VTDV--------IRINGrPVVLGVFTT-QYNS---IPGSAVCAFDMDDIEKVFEgrfkeqkspdsaWTpvpedrv 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  346 ---RDVCYMRDGKSEegtevayiEYDVSSNcvqLPADTL---YAYPCgsdhtpspMASRVP-LEAAPLLEKT--EARLTA 416
Cdd:cd11242    315 pkpRPGCCAGSGSAE--------KYKTSND---FPDDTLnfiKTHPL--------MDEAVPsIINRPWFTRTmvRYRLTQ 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  417 VAVNVEDG----HTIAFLGDSRGRLHKVyLGAQGEAHTYASVSIQVNSMVSGD--------------LLFDQLQEHLFVM 478
Cdd:cd11242    376 IAVDNAAGpyqnYTVVFLGSEAGTVLKF-LARIGPSGSNGSVFLEEIDVYNPAkcsydgeedrriigLELDRASHALFVA 454

                          330
                   ....*....|
gi 1756842681  479 TQSMVVKVPI 488
Cdd:cd11242    455 FSGCVIRVPL 464
rne PRK10811
ribonuclease E; Reviewed
 697-916 4.24e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 48.88  E-value: 4.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  697 SAAPLTkSSTAAPTMATK------PVTTPVHVGPSTVPHTEAIHVTPSAAwEATTEPAQSPsyTRLSLPTEGASLQAATE 770
Cdd:PRK10811   823 SPMPLT-VACASPEMASGkvwiryPVVRPQDVQVEEQREAEEVQVQPVVA-EVPVAAAVEP--VVSAPVVEAVAEVVEEP 898

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  771 APLPPPADNPVTVPETTSP---AAPVFSSPsknmdHIALPTEGPATAQEARHTDPPTTlggSPLHTSPVAAVTLSPHVts 847
Cdd:PRK10811   899 VVVAEPQPEEVVVVETTHPeviAAPVTEQP-----QVITESDVAVAQEVAEHAEPVVE---PQDETADIEEAAETAEV-- 968

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1756842681  848 fkwpPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDDTPgSPGTELPVSGLPTSAP------PQWLTELQDTEDW 916
Cdd:PRK10811   969 ----VVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAP-AQVPEATVEHNHATAPmtrapaPEYVPEAPRHSDW 1038
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
1088-1133 6.95e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 42.15  E-value: 6.95e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1756842681  1088 NCSVgHTDCSRCQTADSKYnCVWCGGDNpSCIFRGSCKEEIEDL----CP 1133
Cdd:smart00423    1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSRRQNWlsggCP 47
rne PRK10811
ribonuclease E; Reviewed
 693-889 7.03e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 48.11  E-value: 7.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  693 VHPSSAAPLTKSSTAAPTMATKPVTTPVHVGPsTVPHTEAIHVTPsaaweATTEPAQSPSYTRLSLPTEGASLQAATEAP 772
Cdd:PRK10811   855 VEEQREAEEVQVQPVVAEVPVAAAVEPVVSAP-VVEAVAEVVEEP-----VVVAEPQPEEVVVVETTHPEVIAAPVTEQP 928

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  773 LPPPADNPVTVPETTSPAAPVfsspsknmdhiALPTEGPATAQEARHTDPPTTLGGSPLHTSPVAAVTLSPHVTSFKWPP 852
Cdd:PRK10811   929 QVITESDVAVAQEVAEHAEPV-----------VEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAV 997

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1756842681  853 SPFPTTEALTSAI------SSPQT----PSQVPGSPVVSDDDTPGSP 889
Cdd:PRK10811   998 EPEVAPAQVPEATvehnhaTAPMTrapaPEYVPEAPRHSDWQRPTFA 1044
PRK10118 PRK10118
flagellar hook length control protein FliK;
715-848 8.74e-05

flagellar hook length control protein FliK;


Pssm-ID: 236652 [Multi-domain]  Cd Length: 408  Bit Score: 47.17  E-value: 8.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  715 PVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGASLQAA-TEAPLPPPADNPVTVPETTSPAAPV 793
Cdd:PRK10118   154 DNTTPVADAPSTVLPAEKPTLLTKDMPSAPQDETHTLSSDEHEKGLTSAQLTTAqPDDAPGTPAQPLTPLAAEAQAKAEV 233

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1756842681  794 FSSPSkNMDHIALPTEGPATAQearhtdpPTTLGGSPLHTSPVAA----VTLSPHVTSF 848
Cdd:PRK10118   234 ISTPS-PVTAAASPTITPHQTQ-------PLPTAAAPVLSAPLGShewqQSLSQHITLF 284
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1227-1305 9.46e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.07  E-value: 9.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1227 PELKSIVPTQGPKAGGTCLTLLGSKLltG-HPNEI--SVLLGDLPCKIL--SEMTEDQLACQTSPS-NVSTELPVTIKYG 1300
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNL--GlRKNDVrhGVRVGGVPCNPEppEYSSSEKIVCTTGPAgNPVFNGPVEVTVG 78


                   ....*
gi 1756842681 1301 EQERR 1305
Cdd:cd01180     79 HGSFR 83
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
697-874 9.56e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 47.29  E-value: 9.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  697 SAAPLTKSSTAAptmATKPVTTPVHVGPSTVPHTEAihvtpsAAWEATTEPAQSPSYTRLSLPTEGASlQAATEAPLPPP 776
Cdd:PRK12727   110 AAMALRQPVSVP---RQAPAAAPVRAASIPSPAAQA------LAHAAAVRTAPRQEHALSAVPEQLFA-DFLTTAPVPRA 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  777 ADNPVTVPettsPAAPVfsspsknmdhIALPTEGPATAQEARHTDPPTTLGGSPLHTSPVAAVTLSPHVTSFKWPPSPfP 856
Cdd:PRK12727   180 PVQAPVVA----APAPV----------PAIAAALAAHAAYAQDDDEQLDDDGFDLDDALPQILPPAALPPIVVAPAAP-A 244

                          170
                   ....*....|....*...
gi 1756842681  857 TTEALTSAISSPQTPSQV 874
Cdd:PRK12727   245 ALAAVAAAAPAPQNDEEL 262
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 1088-1127 1.23e-04

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.54  E-value: 1.23e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1756842681 1088 NCSvGHTDCSRCQTADSkYNCVWCGGDNpSCIFRGSCKEE 1127
Cdd:pfam01437    1 RCS-QYTSCSSCLAARD-PYCGWCSSEG-RCVRRSACGAP 37
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 679-832 1.41e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 47.03  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  679 TIIYNERAQIPISIVHPSSAAPLTKSStAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSytrlsl 758
Cdd:PHA03269    17 LIIANLNTNIPIPELHTSAATQKPDPA-PAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPH------ 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1756842681  759 ptegaslQAATEAPLPPPADNPVTVPeTTSPAAPVFSSPSKNMDHIALPTEG----PATAQEARHTDPPTTLGGSPLH 832
Cdd:PHA03269    90 -------QAASRAPDPAVAPQLAAAP-KPDAAEAFTSAAQAHEAPADAGTSAaskkPDPAAHTQHSPPPFAYTRSMEH 159
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 683-934 1.78e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 1.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  683 NERAQIPISIVHPSSAAPLTKSSTAAPTMATKPVTTPVHVGPSTVPhteaihvTPSAAWEATTEPAQSPSYTRlslPTEG 762
Cdd:PRK07764   579 GGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAP-------AAPAPAGAAAAPAEASAAPA---PGVA 648

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  763 ASLQAATEAPLPPPADNPVTVPETTSPAAPvfsspsknmdhialptEGPATAQEARHTDPPTTLGGSPLHTSPVAAVTLS 842
Cdd:PRK07764   649 APEHHPKHVAVPDASDGGDGWPAKAGGAAP----------------AAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG 712

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  843 PHVTSFKWPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDDTPGSPGTELPVSGLPTSAPPQWLTELQDTEDWMDLLQA 922
Cdd:PRK07764   713 QADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792

                          250
                   ....*....|..
gi 1756842681  923 ENDTSLFSASTL 934
Cdd:PRK07764   793 MDDEDRRDAEEV 804
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1678-1788 2.82e-04

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 44.79  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1678 LFLTKFIHTL--EIQRTFSPRDRAYVASLLTVSLHGKlEYFTDILKTLLNDLVEQyvAKNPKLMLRRTeTVVEKLLTNWM 1755
Cdd:cd04519      8 LLLTESPLALlrELSQVLPVKDKEEVATALLRIFESR-GLALEFLRYLVRSEVKN--TKNPNTLFRGN-SLATKLLDQYM 83

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1756842681 1756 SICLYAFVRDSVGEPLYMLFRGIKHQVDKGPVD 1788
Cdd:cd04519     84 KLVGQEYLKETLSPLIREILESKESCEIDTKLP 116
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 683-905 4.78e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 4.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  683 NERAQIPISIVHPSSAA-PLTKSSTAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSA--AWEATTEPAQSPSYTRLSLP 759
Cdd:PHA03307   157 ASPAAVASDAASSRQAAlPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISasASSPAPAPGRSAADDAGASS 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  760 TEGASLQAA-------TEAPLPPPAdnPVTVPetTSPAAPVFSSPSKNmDHialPTEGPATAQEARHTDPPTTLGGSPLH 832
Cdd:PHA03307   237 SDSSSSESSgcgwgpeNECPLPRPA--PITLP--TRIWEASGWNGPSS-RP---GPASSSSSPRERSPSPSPSSPGSGPA 308

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1756842681  833 TSPVAAVTLSPHVTSFKwPPSPFPTTEALTSAISSPQTPSQVPGSPVVSDDDTPGSPGTELPVSGLPTSAPPQ 905
Cdd:PHA03307   309 PSSPRASSSSSSSRESS-SSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAA 380
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1317-1439 4.98e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 40.90  E-value: 4.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681 1317 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPkIRVTVspserrrrgvgrwrrivpdsecpEGSLCSIQQfeepclVNSS 1396
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPR-VRVTV-----------------------GGVPCKVLN------VSST 50

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1756842681 1397 YlILCKTPAINlLLRSVRIKLEFILDNLSFDFNSlhPMPFSYE 1439
Cdd:cd00603     51 E-IVCRTPAAA-TPGEGPVEVTVDGANVSARVLS--NTTFTYV 89
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 728-864 9.66e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.32  E-value: 9.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  728 PHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTegaslQAATEAPLPPPADNPVTVPETTSPAAPVFSSPSknmdhiALP 807
Cdd:PRK14951   366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAA-----AAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAA------AAP 434

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1756842681  808 TEGPATAQEARHTDPPTTLGGSPLHTSPVAAVTLSPHVTSFKWPPSPFPTTEALTSA 864
Cdd:PRK14951   435 AAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 695-827 1.56e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  695 PSSAAPLTKSSTAAPtmATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTR-LSLPTEGASLQAATEAPL 773
Cdd:PRK14951   375 PAEKKTPARPEAAAP--AAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAApAAAPAAAPAAVALAPAPP 452

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1756842681  774 PPPADNPVTVPETTSPAAPVFSSPsknmdhialPTEGPATAQEARhtdPPTTLG 827
Cdd:PRK14951   453 AQAAPETVAIPVRVAPEPAVASAA---------PAPAAAPAAARL---TPTEEG 494
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 695-826 1.68e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  695 PSSAAPltksstAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGAslqAATEAPLP 774
Cdd:PRK14951   366 PAAAAE------AAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAA---PAAAAPAA 436

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1756842681  775 PPADNPVTV---PETTSPAAPVFSSPSKNMDhialPTEGPATAQEARHTDPPTTL 826
Cdd:PRK14951   437 APAAAPAAValaPAPPAQAAPETVAIPVRVA----PEPAVASAAPAPAAAPAAAR 487
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
695-886 1.70e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 43.11  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  695 PSSAAPlTKSSTAAPTMATKPvTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGAslqaateapLP 774
Cdd:pfam05539  168 PKTAVT-TSKTTSWPTEVSHP-TYPSQVTPQSQPATQGHQTATANQRLSSTEPVGTQGTTTSSNPEPQT---------EP 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  775 PPADNPvtvPETTSPAAPVFSSPSKNmdhialptegpATAQEARHTDPPTtlggsplhTSPVAAVTLSPHVTSFKWPPSP 854
Cdd:pfam05539  237 PPSQRG---PSGSPQHPPSTTSQDQS-----------TTGDGQEHTQRRK--------TPPATSNRRSPHSTATPPPTTK 294

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1756842681  855 FPTTEALT-SAISSPQTPSQVPGSPVVSDDDTP 886
Cdd:pfam05539  295 RQETGRPTpRPTATTQSGSSPPHSSPPGVQANP 327
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 695-994 3.77e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  695 PSSAAPLTKSSTAAPTMATKPVTTPVHVGPSTVPHTEAIHVTPSAAWEATTEPAQSPSYTRLSLPTEGASLQAAtEAPLP 774
Cdd:PRK07764   406 PAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAA-PAPAP 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  775 PPADNPVTVPETTSPAAPvfSSPSKNMDHI---------ALPTEGPATA----QEARHT--DPPT-TLGgsplHTSPVAA 838
Cdd:PRK07764   485 PAAPAPAAAPAAPAAPAA--PAGADDAATLrerwpeilaAVPKRSRKTWaillPEATVLgvRGDTlVLG----FSTGGLA 558

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  839 ---------------------------VTLSPHVTSFKWPPSPFPTTEALTSAISSPQTPSQvPGSPVVSDDDTPGSPGT 891
Cdd:PRK07764   559 rrfaspgnaevlvtalaeelggdwqveAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAA-PAAPAAPAPAGAAAAPA 637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  892 ELPVSGLPTSAPPQWLTELQDTEDWMDllqaenDTSLFSASTLLSGDGDSSERDVPDFPRILHPDLDYQYDAPEFWEESE 971
Cdd:PRK07764   638 EASAAPAPGVAAPEHHPKHVAVPDASD------GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPA 711

                          330       340
                   ....*....|....*....|...
gi 1756842681  972 EPSWGPNACPCVQGIQGSSLFPV 994
Cdd:PRK07764   712 GQADDPAAQPPQAAQGASAPSPA 734
PRK10856 PRK10856
cytoskeleton protein RodZ;
695-778 4.85e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.55  E-value: 4.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1756842681  695 PSSAAPLTKSSTAAPTMATKPVTTPVHVGPSTVPhteaihVTPSAaweATTEPAQSPSYTRLSLPTEGASLQAATEAPLP 774
Cdd:PRK10856   176 PAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAV------VAPSQ---ANVDTAATPAPAAPATPDGAAPLPTDQAGVST 246


                   ....
gi 1756842681  775 PPAD 778
Cdd:PRK10856   247 PAAD 250
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
650-677 6.69e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 36.37  E-value: 6.69e-03
                            10        20
                    ....*....|....*....|....*....
gi 1756842681   650 CQKCVSSLWG-CNWCIQQHLCTHKATCEE 677
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDS 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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